Pub Date : 2019-06-01DOI: 10.11620/IJOB.2019.44.2.31
Y. You
{"title":"Virulence genes of Streptococcus mutans and dental caries","authors":"Y. You","doi":"10.11620/IJOB.2019.44.2.31","DOIUrl":"https://doi.org/10.11620/IJOB.2019.44.2.31","url":null,"abstract":"","PeriodicalId":14180,"journal":{"name":"International Journal of Oral Biology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83466217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-01DOI: 10.11620/IJOB.2019.44.2.55
Se-Jin Sung, Kyung-Min Kang, Kyung-Hyun Lee, S. Yoo, J. Kook, Dae Sung Lee, Sang-Joun Yu
{"title":"Effect of Garcinia mangostana L. and propolis extracts on the inhibition of inflammation and alveolar bone loss in ligature-induced periodontitis in rats","authors":"Se-Jin Sung, Kyung-Min Kang, Kyung-Hyun Lee, S. Yoo, J. Kook, Dae Sung Lee, Sang-Joun Yu","doi":"10.11620/IJOB.2019.44.2.55","DOIUrl":"https://doi.org/10.11620/IJOB.2019.44.2.55","url":null,"abstract":"","PeriodicalId":14180,"journal":{"name":"International Journal of Oral Biology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90080105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-30DOI: 10.11620/IJOB.2019.44.1.27
M. Kang, Boyeon Kim, Hyoung-Geun Park, Eunseok Lee
{"title":"Clinical evaluation of cetylpyridinium chloridecontaining mouthwash in halitosis","authors":"M. Kang, Boyeon Kim, Hyoung-Geun Park, Eunseok Lee","doi":"10.11620/IJOB.2019.44.1.27","DOIUrl":"https://doi.org/10.11620/IJOB.2019.44.1.27","url":null,"abstract":"","PeriodicalId":14180,"journal":{"name":"International Journal of Oral Biology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80068847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-30DOI: 10.11620/IJOB.2019.44.1.20
Y. Kim, Jooyeon Park, Hyun-Joo Park, Mi-Kyoung Kim, Yong-Il Kim, S. Bae, H. J. Kim, M. Bae
{"title":"Porphyromonas gingivalis lipopolysaccharide stimulates vascular smooth muscle cell migration through signal transducer and activator of transcription 3-mediated matrix metalloproteinase-9 expression","authors":"Y. Kim, Jooyeon Park, Hyun-Joo Park, Mi-Kyoung Kim, Yong-Il Kim, S. Bae, H. J. Kim, M. Bae","doi":"10.11620/IJOB.2019.44.1.20","DOIUrl":"https://doi.org/10.11620/IJOB.2019.44.1.20","url":null,"abstract":"","PeriodicalId":14180,"journal":{"name":"International Journal of Oral Biology","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84770045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-30DOI: 10.11620/IJOB.2019.44.1.1
Sung-Jin Kim, S. J. Moon, J. Seo
Osteoporosis is a common disease where bone mass is reduced, leading to an increased risk of bone fracture. Half of Caucasian women and a fifth of men experience osteoporosisrelated bone fracture in the course of lifetime [1]. Treatment of osteoporosis-related fracture causes enormous socioeconomic burden, costing nearly $17 billion in 2005 in the U.S.; it is expected to double or triple in the next four decades due to rapidly aging population [2]. Osteoporosis is caused by an imbalance of osteoblastic bone formation and osteoclastic bone resorption. Thus, antiosteoporosis medications aim to reduce the risk of bone fracture either by increasing bone formation or suppressing bone resorption. Currently, four classes of anti-resorptive agents and one class of anabolic agent are approved by the U.S. Food and Drug Administration for the treatment of osteoporosis (Table 1). However, these medications have failed to increase bone formation or decrease bone resorption in isolation due to the closed coupling of osteoblasts and osteoclasts whereby changes in differentiation or activity of one cell type directly affect the other [3]. This phenomenon not only limits the efficacy of anti-osteoporosis drugs, but also is associated with significant side effects [4]. In this article, we review the biological aspects of anti-osteoporosis drugs, focusing on the mechanisms of action and osteoblast–osteoclast coupling.
{"title":"Biological characteristics of osteoporosis drugs: the effect of osteoblast–osteoclast coupling","authors":"Sung-Jin Kim, S. J. Moon, J. Seo","doi":"10.11620/IJOB.2019.44.1.1","DOIUrl":"https://doi.org/10.11620/IJOB.2019.44.1.1","url":null,"abstract":"Osteoporosis is a common disease where bone mass is reduced, leading to an increased risk of bone fracture. Half of Caucasian women and a fifth of men experience osteoporosisrelated bone fracture in the course of lifetime [1]. Treatment of osteoporosis-related fracture causes enormous socioeconomic burden, costing nearly $17 billion in 2005 in the U.S.; it is expected to double or triple in the next four decades due to rapidly aging population [2]. Osteoporosis is caused by an imbalance of osteoblastic bone formation and osteoclastic bone resorption. Thus, antiosteoporosis medications aim to reduce the risk of bone fracture either by increasing bone formation or suppressing bone resorption. Currently, four classes of anti-resorptive agents and one class of anabolic agent are approved by the U.S. Food and Drug Administration for the treatment of osteoporosis (Table 1). However, these medications have failed to increase bone formation or decrease bone resorption in isolation due to the closed coupling of osteoblasts and osteoclasts whereby changes in differentiation or activity of one cell type directly affect the other [3]. This phenomenon not only limits the efficacy of anti-osteoporosis drugs, but also is associated with significant side effects [4]. In this article, we review the biological aspects of anti-osteoporosis drugs, focusing on the mechanisms of action and osteoblast–osteoclast coupling.","PeriodicalId":14180,"journal":{"name":"International Journal of Oral Biology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83352694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-30DOI: 10.11620/IJOB.2019.44.1.8
Tae-Hoon Kim, H. Hwang, Jeong Hee Kim
{"title":"Optimization of ultra-fast convection polymerase chain reaction conditions for pathogen detection with nucleic acid lateral flow immunoassay","authors":"Tae-Hoon Kim, H. Hwang, Jeong Hee Kim","doi":"10.11620/IJOB.2019.44.1.8","DOIUrl":"https://doi.org/10.11620/IJOB.2019.44.1.8","url":null,"abstract":"","PeriodicalId":14180,"journal":{"name":"International Journal of Oral Biology","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85991403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.11620/IJOB.2019.44.1.14
Yoon-Jeong Choi, Seok-Woo Lee
The present study aimed at evaluating serum immunoglobulin G (IgG) avidity to Porphyromonas gingivalis in elderly patients with mild and severe chronic periodontitis. The avidity of antibodies against P. gingivalis present in the sera of 18 patients with mild chronic periodontitis and 18 patients with severe chronic periodontitis was evaluated using an ammonium thiocyanate-dissociated enzyme-linked immunosorbent assay (ELISA). The results showed that the mean absorbance value in serum IgG antibody titers was significantly higher in the severe chronic periodontitis group than in the mild chronic periodontitis group (198 ± 35 ELISA unit [EU] vs. 142 ± 32 EU, p < 0.01). However, there was no significant difference between the two groups in antibody avidity (65 ± 57 EU vs. 54 ± 27 EU). These findings suggest that humoral immune responses to P. gingivalis between mild and severe chronic periodontitis in elderly patients are characterized by the differences in the quantity rather than the quality of the antibodies.
本研究旨在评估老年轻、重度慢性牙周炎患者血清免疫球蛋白G (IgG)对牙龈卟啉单胞菌的亲和力。采用硫氰酸铵解离酶联免疫吸附试验(ELISA)对18例轻度慢性牙周炎患者和18例重度慢性牙周炎患者血清中牙龈卟啉卟啉抗体的亲和力进行了评价。结果显示，重度慢性牙周炎组血清IgG抗体滴度的平均吸光度值明显高于轻度慢性牙周炎组(198±35 ELISA单位[EU]比142±32 EU, p < 0.01)。然而，两组之间的抗体贪婪度无显著差异(65±57 EU vs. 54±27 EU)。这些结果表明，老年慢性牙周炎患者对牙龈假单胞菌的体液免疫反应主要表现为抗体数量的差异，而非抗体质量的差异。
{"title":"Avidity of serum immunoglobulin G antibodies to Porphyromonas gingivalis in the elderly with chronic periodontitis","authors":"Yoon-Jeong Choi, Seok-Woo Lee","doi":"10.11620/IJOB.2019.44.1.14","DOIUrl":"https://doi.org/10.11620/IJOB.2019.44.1.14","url":null,"abstract":"The present study aimed at evaluating serum immunoglobulin G (IgG) avidity to Porphyromonas gingivalis in elderly patients with mild and severe chronic periodontitis. The avidity of antibodies against P. gingivalis present in the sera of 18 patients with mild chronic periodontitis and 18 patients with severe chronic periodontitis was evaluated using an ammonium thiocyanate-dissociated enzyme-linked immunosorbent assay (ELISA). The results showed that the mean absorbance value in serum IgG antibody titers was significantly higher in the severe chronic periodontitis group than in the mild chronic periodontitis group (198 ± 35 ELISA unit [EU] vs. 142 ± 32 EU, p < 0.01). However, there was no significant difference between the two groups in antibody avidity (65 ± 57 EU vs. 54 ± 27 EU). These findings suggest that humoral immune responses to P. gingivalis between mild and severe chronic periodontitis in elderly patients are characterized by the differences in the quantity rather than the quality of the antibodies.","PeriodicalId":14180,"journal":{"name":"International Journal of Oral Biology","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83105616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-31DOI: 10.11620/IJOB.2018.43.4.217
Yurisong, Lee Hyun Ah, N. Sam, Chung Jin
{"title":"Effect of Various Agents on Oral Bacterial Phagocytosis in THP-1 Cells","authors":"Yurisong, Lee Hyun Ah, N. Sam, Chung Jin","doi":"10.11620/IJOB.2018.43.4.217","DOIUrl":"https://doi.org/10.11620/IJOB.2018.43.4.217","url":null,"abstract":"","PeriodicalId":14180,"journal":{"name":"International Journal of Oral Biology","volume":"125 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73869609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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