Venkata Jagadeswara Reddy Bandi, Narasamma Sanampudi, Sai Kumar Reddy Velamuri, Ramaiah Maddi
All of us have suffered from acidity at some point or other. Severe pain in the stomach, burning, bloating, hiccupping, flatulence, and acid reflux is the common symptoms. While our immediate and natural response is to reach for that antacid when suffering from acidity, it will not give you long-term relief. Instead, we suggest, opt for these Herbal treasures to cure and control acidity and boost your overall stomach health. We give you the most effective remedies for acidity, heartburn, and indigestion. The present article is an overall review of herbal formulations used in all different fields like Ayurvedha, Sidha, and the Unani system of medicine to educate people about the benefits of herbal formulations and their uses. Gastric acidity is a common clinical problem, affecting millions of people worldwide. patients are recognized by both classic and atypical symptoms. Here, we discuss a detailed review of herbal medicines marketed & available in India for the management of gastric acidity. You get detailed information about tablets, capsules & syrups for acidity and their combinations.
{"title":"A detailed review of herbal formulations marketed and available in India for the treatement and management of gastric acidity","authors":"Venkata Jagadeswara Reddy Bandi, Narasamma Sanampudi, Sai Kumar Reddy Velamuri, Ramaiah Maddi","doi":"10.46796/ijpc.v3i2.313","DOIUrl":"https://doi.org/10.46796/ijpc.v3i2.313","url":null,"abstract":"All of us have suffered from acidity at some point or other. Severe pain in the stomach, burning, bloating, hiccupping, flatulence, and acid reflux is the common symptoms. While our immediate and natural response is to reach for that antacid when suffering from acidity, it will not give you long-term relief. Instead, we suggest, opt for these Herbal treasures to cure and control acidity and boost your overall stomach health. We give you the most effective remedies for acidity, heartburn, and indigestion. The present article is an overall review of herbal formulations used in all different fields like Ayurvedha, Sidha, and the Unani system of medicine to educate people about the benefits of herbal formulations and their uses. Gastric acidity is a common clinical problem, affecting millions of people worldwide. patients are recognized by both classic and atypical symptoms. Here, we discuss a detailed review of herbal medicines marketed & available in India for the management of gastric acidity. You get detailed information about tablets, capsules & syrups for acidity and their combinations. ","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74285926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicinal plants have been used from ancient time for the treatment and well-being of human beings. Evolvulus alsinoides Linn. is also been extensively used as traditional medicine in various culture. Evolvulus alsinoides Linn. is often prostrate, slender and wiry with long hairs. The plant is common in tropical and sub-tropical regions of the world. The metabolites of the plant are considered to be effective in treating many ailments. Various dosage forms and a wide array of extracts have been used in traditional system of medicine with potent therapeutic activity. It has anticonvulsant, nootropic, anti-inflammatory, antimicrobial, antioxidant, anxiolytic, cardio protective effects. The present study deals the pharmacognostic evaluation and investigation of systematics, macro-microscopy, physico-chemical studies, phytochemical studies and TLC assay & HPTLC analytical studies of this medicinally important plant species. Study not only covers critical aspects of pharmacognosy but also important phytochemical investigation with reference to its known bioactive secondary metabolites. It helps in the quality evaluation and standardization of herbal drug. Pharmacognostic diagnosis is very helpful to improve cultivation procedure, plant safety, drug quality and its efficacy along with authentication of commercial samples, used in various formulations.
{"title":"Pharmacognostic Pharmacognostic evaluation and investigation of revitalizer herb Evolvulus alsinoides Linn.","authors":"M.P.V. Vikram Singh, Vinaykumar Prajapati Drvinay","doi":"10.46796/ijpc.v3i2.299","DOIUrl":"https://doi.org/10.46796/ijpc.v3i2.299","url":null,"abstract":"Medicinal plants have been used from ancient time for the treatment and well-being of human beings. Evolvulus alsinoides Linn. is also been extensively used as traditional medicine in various culture. Evolvulus alsinoides Linn. is often prostrate, slender and wiry with long hairs. The plant is common in tropical and sub-tropical regions of the world. The metabolites of the plant are considered to be effective in treating many ailments. Various dosage forms and a wide array of extracts have been used in traditional system of medicine with potent therapeutic activity. It has anticonvulsant, nootropic, anti-inflammatory, antimicrobial, antioxidant, anxiolytic, cardio protective effects. The present study deals the pharmacognostic evaluation and investigation of systematics, macro-microscopy, physico-chemical studies, phytochemical studies and TLC assay & HPTLC analytical studies of this medicinally important plant species. Study not only covers critical aspects of pharmacognosy but also important phytochemical investigation with reference to its known bioactive secondary metabolites. It helps in the quality evaluation and standardization of herbal drug. Pharmacognostic diagnosis is very helpful to improve cultivation procedure, plant safety, drug quality and its efficacy along with authentication of commercial samples, used in various formulations.","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83107399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This review focused on the usage of bromelain in numerous applications, as well as the most recent literature on the chemistry, extraction, and purification of bromelain from pineapple (Ananas comosus). Bromelain is a crude, aqueous extract obtained from the stems and fruits of pineapple, leading edible member of the family Bromeliaceae. Bromelain contains a mixture of different thiol endopeptidases as well as phosphatases, glucosidases, peroxidases, cellulases, & glycoproteins. It exerts its enzymatic activity over a PH range 4.5 – 9.5. The isolation & purification of bromelain has been done by various methods includes aqueous two-phase extraction, reverse micellar extraction, ultrafiltration & precipitation & chromatographic techniques. Bromelain, a cysteine protease, has found commercial use in a variety of industries including food, beverage, tenderization, cosmetic, pharmaceutical, and textile. Bromelain act as an immunomodulatory, anti-inflammatory agent, anti-oedematous, anti-thrombotic & anti-metastatic. Although the precise mechanism of action of bromelain has not been established, bromelain has received widespread acceptance as a phytotherapeutic agent due to its long history of safety and absence of adverse effects
{"title":"A review on chemistry, therapeutic applications, extraction & purification of bromelain","authors":"Anna-Gay D. Nelson, Ashly Peter, Fels Saju","doi":"10.46796/ijpc.v3i1.297","DOIUrl":"https://doi.org/10.46796/ijpc.v3i1.297","url":null,"abstract":"This review focused on the usage of bromelain in numerous applications, as well as the most recent literature on the chemistry, extraction, and purification of bromelain from pineapple (Ananas comosus). Bromelain is a crude, aqueous extract obtained from the stems and fruits of pineapple, leading edible member of the family Bromeliaceae. Bromelain contains a mixture of different thiol endopeptidases as well as phosphatases, glucosidases, peroxidases, cellulases, & glycoproteins. It exerts its enzymatic activity over a PH range 4.5 – 9.5. The isolation & purification of bromelain has been done by various methods includes aqueous two-phase extraction, reverse micellar extraction, ultrafiltration & precipitation & chromatographic techniques. Bromelain, a cysteine protease, has found commercial use in a variety of industries including food, beverage, tenderization, cosmetic, pharmaceutical, and textile. Bromelain act as an immunomodulatory, anti-inflammatory agent, anti-oedematous, anti-thrombotic & anti-metastatic. Although the precise mechanism of action of bromelain has not been established, bromelain has received widespread acceptance as a phytotherapeutic agent due to its long history of safety and absence of adverse effects","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78071926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The ground water is contaminated, its quality cannot be restored by stopping the pollutants from the source. The common pollutants of groundwater are discharge of agricultural, domestic, and industrial waste, pesticides etc., which leads to water- borne diseases. Water-borne diseases may be of microbial origin such as diarrhea, dysentery, cholera, typhoid and chemical origin such as flurosis and methemoglobinemia. Water Quality Index (WQI) provides a single number that expresses overall quality at certain location and time based on several water quality parameters. The objective of an index is to turn complex quality data in to information that is understandable and useable by the public. The present study was undertaken to assess the suitability of 8 drinking water sources of Doiwala block of Dehradun for drinking purpose during pre- and post-monsoon seasons of the year 2021. The obtained water quality data of drinking water sources was further applied for the calculation of weighted arithmetic Water Quality Index (WQI). Most of the water sources during pre-monsoon season were graded as ‘A’ with good quality due to having low WQI values. However, Two sites were found with ‘B’ class, another two were classified as ‘C’ grade owing to higher WQI values and thus, categorized as having poor water quality. Two sampling sites were recorded with highest WQI value (59.29) and (68.24) its water quality was found poor for drinking purpose. During post-monsoon season, all analyzed water sources showed low WQI values, which indicates ‘A’ class i.e. excellent water quality. The higher WQI values during pre-monsoon season have been inferred owing to relatively higher calcium, magnesium and iron concentrations assessed during the period of study.
{"title":"ESTIMATION OF WATER QUALITY STATUS FOR DRINKING WATER SOURCES OF DOIWALA BLOCK OF DEHRADUN DISTRICT, UTTARAKHAND","authors":"Sonu Dwivedi","doi":"10.46796/ijpc.v3i1.298","DOIUrl":"https://doi.org/10.46796/ijpc.v3i1.298","url":null,"abstract":"The ground water is contaminated, its quality cannot be restored by stopping the pollutants from the source. The common pollutants of groundwater are discharge of agricultural, domestic, and industrial waste, pesticides etc., which leads to water- borne diseases. Water-borne diseases may be of microbial origin such as diarrhea, dysentery, cholera, typhoid and chemical origin such as flurosis and methemoglobinemia. Water Quality Index (WQI) provides a single number that expresses overall quality at certain location and time based on several water quality parameters. The objective of an index is to turn complex quality data in to information that is understandable and useable by the public. \u0000The present study was undertaken to assess the suitability of 8 drinking water sources of Doiwala block of Dehradun for drinking purpose during pre- and post-monsoon seasons of the year 2021. The obtained water quality data of drinking water sources was further applied for the calculation of weighted arithmetic Water Quality Index (WQI). Most of the water sources during pre-monsoon season were graded as ‘A’ with good quality due to having low WQI values. However, Two sites were found with ‘B’ class, another two were classified as ‘C’ grade owing to higher WQI values and thus, categorized as having poor water quality. Two sampling sites were recorded with highest WQI value (59.29) and (68.24) its water quality was found poor for drinking purpose. During post-monsoon season, all analyzed water sources showed low WQI values, which indicates ‘A’ class i.e. excellent water quality. The higher WQI values during pre-monsoon season have been inferred owing to relatively higher calcium, magnesium and iron concentrations assessed during the period of study.","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"162 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75765637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prasad Bingidoddi, V. J. Marabathuni, Naidu Narapusetty
The study was designed to investigate the effect of cyclodextrins (CDs) on the solubility, dissolution rate, and bioavailability of efavirenz by forming inclusion complexes. Prepared inclusion complexes were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry (DSC), and X-ray diffraction (XRD) studies. In vitro dissolution study was performed using phosphate buffer pH 6.4, distilled water, and HCl buffer pH 1.2 as dissolution medium. Among all efavirenz–cyclodextrins complexes, efavirenz–DM-β-CD inclusion complex (1:3) prepared by coprecipitation method showed 1.53-fold and 4.11-fold increase in absorption along with 2.1-fold and 2.97-fold increase in dissolution rate in comparison with Pletoz-50 and pure efavirenz, respectively.
{"title":"Formulation development & invitro evaluation of efavirenz cyclodexprin complexes im-mediate release tablets","authors":"Prasad Bingidoddi, V. J. Marabathuni, Naidu Narapusetty","doi":"10.46796/ijpc.v3i1.263","DOIUrl":"https://doi.org/10.46796/ijpc.v3i1.263","url":null,"abstract":"The study was designed to investigate the effect of cyclodextrins (CDs) on the solubility, dissolution rate, and bioavailability of efavirenz by forming inclusion complexes. Prepared inclusion complexes were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry (DSC), and X-ray diffraction (XRD) studies. In vitro dissolution study was performed using phosphate buffer pH 6.4, distilled water, and HCl buffer pH 1.2 as dissolution medium. Among all efavirenz–cyclodextrins complexes, efavirenz–DM-β-CD inclusion complex (1:3) prepared by coprecipitation method showed 1.53-fold and 4.11-fold increase in absorption along with 2.1-fold and 2.97-fold increase in dissolution rate in comparison with Pletoz-50 and pure efavirenz, respectively.","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84691832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The research explain about Miglitol site in the body and also to achieve and maintain the desired ISD concentration, having 2 hour half-life and low bioavilability. The paper give information about nine formulations formulated by using HPMC K15M, Ethyl cellulose and karaya gum in different proportions. The FTIR Spectra revealed that, there was no interaction between polymers and Miglitol. As the polymer ratio was increased, the mean particle size of Miglitol microspheres was also increased. From the results it can be inferred that there was a proper distribution of Miglitol in the microspheres and the deviation was within the acceptable limits. On the basis of release data and graphical analysis formulation F6 containing HPMC K15M showed a good controlled release profile up to 12hrs with maximum entrapment efficiency because of high polymer concentration and follows zero order kinetics with super case II transport mechanism.
{"title":"Controlled release miglitol microspheres formulation development and evaluation","authors":"P. K, V. J. Marabathuni, Naidu Narapusetty","doi":"10.46796/ijpc.v3i1.260","DOIUrl":"https://doi.org/10.46796/ijpc.v3i1.260","url":null,"abstract":"The research explain about Miglitol site in the body and also to achieve and maintain the desired ISD concentration, having 2 hour half-life and low bioavilability. The paper give information about nine formulations formulated by using HPMC K15M, Ethyl cellulose and karaya gum in different proportions. The FTIR Spectra revealed that, there was no interaction between polymers and Miglitol. As the polymer ratio was increased, the mean particle size of Miglitol microspheres was also increased. From the results it can be inferred that there was a proper distribution of Miglitol in the microspheres and the deviation was within the acceptable limits. On the basis of release data and graphical analysis formulation F6 containing HPMC K15M showed a good controlled release profile up to 12hrs with maximum entrapment efficiency because of high polymer concentration and follows zero order kinetics with super case II transport mechanism.","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"394 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78082041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Formulation research is oriented towards safety, efficacy and quick onset of action of existing drug molecule through novel concepts of drug delivery. Orally disintegrating tablets of Rizatriptan benzoate were prepared by direct compression method to provide faster relief from pain to migraine sufferers. About eleven formulations for the present study were carried out. Croscarmellose sodium, Crospovidone and Sodium starch glycolate (SSG) were used as superdisintegrants, while microcrystalline cellulose was used as diluent. The prepared batches of tablets were evaluated for weight variation, hardness, friability, wetting time, invitro dispersion time, drug content and invitro dissolution studies. The formulation containing combination of Croscarmellose sodium and Sodium starch glycolate showed rapid invitro dispersion time as compared to other formulations. The optimized formulation dispersed in 8 seconds. It also showed a higher water absorption ratio and 99.58% of drug is released within 2 minutes.
{"title":"Formulation development and evaluation of Orally Disintegrating Tablets Rizatriptan Benzoate","authors":"Saibabu Ch, P. Triveni","doi":"10.46796/IJPC.V2I4.246","DOIUrl":"https://doi.org/10.46796/IJPC.V2I4.246","url":null,"abstract":"Formulation research is oriented towards safety, efficacy and quick onset of action of existing drug molecule through novel concepts of drug delivery. Orally disintegrating tablets of Rizatriptan benzoate were prepared by direct compression method to provide faster relief from pain to migraine sufferers. About eleven formulations for the present study were carried out. Croscarmellose sodium, Crospovidone and Sodium starch glycolate (SSG) were used as superdisintegrants, while microcrystalline cellulose was used as diluent. The prepared batches of tablets were evaluated for weight variation, hardness, friability, wetting time, invitro dispersion time, drug content and invitro dissolution studies. The formulation containing combination of Croscarmellose sodium and Sodium starch glycolate showed rapid invitro dispersion time as compared to other formulations. The optimized formulation dispersed in 8 seconds. It also showed a higher water absorption ratio and 99.58% of drug is released within 2 minutes.","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88980962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R Lokeshvar, N. Deepa, K Madhivadhani, P. Divya, M Asuvathaman
Phytochemical constituents (Alkaloids, tannins, saponins, steroid, terpenoid, flavonoids, and cardic glycoside ) of medicinal plant ( Aegle marmelos, Cynodon dactylon, Eclipta prostrata, Pongamia pinnata, Sida acuta and Tridax procumbens)with different Families were Compared and Assessed.The Importance of these plants in ethnomedicine and their Significance in Traditional Medicine and there chemical constituents were discussed
{"title":"Evaluation of phytochemical constituents of some indian Medicinal plants","authors":"R Lokeshvar, N. Deepa, K Madhivadhani, P. Divya, M Asuvathaman","doi":"10.46796/IJPC.V2I3.223","DOIUrl":"https://doi.org/10.46796/IJPC.V2I3.223","url":null,"abstract":"Phytochemical constituents (Alkaloids, tannins, saponins, steroid, terpenoid, flavonoids, and cardic glycoside ) of medicinal plant ( Aegle marmelos, Cynodon dactylon, Eclipta prostrata, Pongamia pinnata, Sida acuta and Tridax procumbens)with different Families were Compared and Assessed.The Importance of these plants in ethnomedicine and their Significance in Traditional Medicine and there chemical constituents were discussed","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74712763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The traditional medical study is an integral part of the culture and the perception of health by indigenous population in almost world since primordial times. India has used its knowledge of traditional or herbal medicine to prevent and cure diseases. As herbal medicine have fewer side effects in comparison with synthetic medicine they are getting increase patient compliance against allopathic medicines. Oral ulcers are very common ailment of the oral mucosal membrane. An open sore of the skin or mucus membrane lining marked by sloughing of inflamed dead tissue is known as a mouth ulcer. In this article we discuss on the topic “herbal gel for the treatment of mouth ulcer”. There is a list of herbs which contain flavonoids which are most commonly used for the treatment.
{"title":"Herbs used in treatment of mouth ulcer- a review","authors":"Nikita Shahare, S. Chouhan, G. Darwhekar","doi":"10.46796/ijpc.v2i3.212","DOIUrl":"https://doi.org/10.46796/ijpc.v2i3.212","url":null,"abstract":"The traditional medical study is an integral part of the culture and the perception of health by indigenous population in almost world since primordial times. India has used its knowledge of traditional or herbal medicine to prevent and cure diseases. As herbal medicine have fewer side effects in comparison with synthetic medicine they are getting increase patient compliance against allopathic medicines. Oral ulcers are very common ailment of the oral mucosal membrane. An open sore of the skin or mucus membrane lining marked by sloughing of inflamed dead tissue is known as a mouth ulcer. In this article we discuss on the topic “herbal gel for the treatment of mouth ulcer”. There is a list of herbs which contain flavonoids which are most commonly used for the treatment. \u0000 ","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83126427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A simple, Accurate, precise method was developed for the simultaneous estimation of the Netupitant and Palonosetron in Pharmaceutical dosage form. The chromatogram was run through Std Discovery C18250 x 4.6 mm, 5m. Mobile phase containing Buffer 0.1% OPA (2.2ph): Acetonitrile taken in the ratio 55:45 was pumped through the column at a flow rate of 1 ml/min. The buffer used in this method was 0.1% OPA. The temperature was maintained at 30°C. The optimized wavelength selected was 220 nm. The retention time of Netupitant and Palonosetron was found to be 2.308min and 3.093min. %RSD of the Netupitant and Palonosetron were and found to be 0.9 and 0.6 respectively. %Recovery was obtained as 99.51% and 99.29% for Netupitant and Palonosetron respectively. LOD, LOQ values obtained from regression equations of Netupitant and Palonosetron were 1.84, 0.01, and 5.59, 0.03 respectively. Regression equation of Netupitant is y = 7232.8x + 3439.3., and y = 28857x + 97.732 of Palonosetron. Retention times were decreased and run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control tests in Industries.
建立了一种简便、准确、精确的同时测定药物剂型中尼妥吡坦和帕洛诺司琼含量的方法。通过Std Discovery C18250 x 4.6 mm, 5m进行色谱。流动相含缓冲液0.1% OPA (2.2ph):取比为55:45的乙腈，以1ml /min的流速泵入柱中。本方法使用的缓冲液为0.1% OPA。温度保持在30℃。选择的最佳波长为220 nm。尼图吡坦和帕洛诺司琼的滞留时间分别为2.308min和3.093min。尼妥吡坦和帕洛诺司琼的RSD分别为0.9和0.6。尼妥吡坦和帕洛诺司琼的回收率分别为99.51%和99.29%。尼妥吡坦和帕洛诺司琼的LOD、LOQ分别为1.84、0.01和5.59、0.03。Netupitant的回归方程为y = 7232.8x + 3439.3。，帕洛诺司琼y = 28857x + 97.732。该方法减少了停留时间，缩短了运行时间，简便、经济，可用于工业中常规的质量控制试验。
{"title":"Development and Validation of New Analytical Method for The Simultaneous Estimation of Netupitant And Palonosetron In Pharmaceutical Dosage Form","authors":"Potluri Surendra, P. Prasanna, K. Thejomoorthy","doi":"10.46796/ijpc.vi.158","DOIUrl":"https://doi.org/10.46796/ijpc.vi.158","url":null,"abstract":"A simple, Accurate, precise method was developed for the simultaneous estimation of the Netupitant and Palonosetron in Pharmaceutical dosage form. The chromatogram was run through Std Discovery C18250 x 4.6 mm, 5m. Mobile phase containing Buffer 0.1% OPA (2.2ph): Acetonitrile taken in the ratio 55:45 was pumped through the column at a flow rate of 1 ml/min. The buffer used in this method was 0.1% OPA. The temperature was maintained at 30°C. The optimized wavelength selected was 220 nm. The retention time of Netupitant and Palonosetron was found to be 2.308min and 3.093min. %RSD of the Netupitant and Palonosetron were and found to be 0.9 and 0.6 respectively. %Recovery was obtained as 99.51% and 99.29% for Netupitant and Palonosetron respectively. LOD, LOQ values obtained from regression equations of Netupitant and Palonosetron were 1.84, 0.01, and 5.59, 0.03 respectively. Regression equation of Netupitant is y = 7232.8x + 3439.3., and y = 28857x + 97.732 of Palonosetron. Retention times were decreased and run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control tests in Industries.","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82141051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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