This article investigates the variation in chemical constituents at different altitudes in the Himalayan region, specifically focusing on the Kumaon region. The study aims to understand the impact of altitude on the chemical composition of plants and its implications for ecological interactions and human health. Extensive field surveys were conducted across various altitudes, and plant samples were collected for chemical analysis. The results revealed significant variations in the chemical constituents of plants at different altitudes, including secondary metabolites such as alkaloids, flavonoids, and phenolic compounds. The study also identified specific altitude-dependent patterns, with certain compounds being more abundant or absent at particular altitudes. These variations in chemical constituents can be attributed to environmental factors such as temperature, humidity, and solar radiation, which change with altitude. The findings highlight the importance of considering altitude as a key factor in studying the chemical ecology of the Himalayan region. Understanding these variations can have significant implications for conservation efforts, pharmaceutical research, and traditional medicine practices in the region. Further research is needed to explore the ecological and physiological mechanisms underlying these altitude-related variations in chemical constituents.
{"title":"The Variation of Chemical Constituents across Altitudes in the Himalayan Kumaon Region: Exploring Nature's Wonders","authors":"Bharat Pandey, Kamal K Pande, Lata Pande","doi":"10.46796/ijpc.v4i4.516","DOIUrl":"https://doi.org/10.46796/ijpc.v4i4.516","url":null,"abstract":"This article investigates the variation in chemical constituents at different altitudes in the Himalayan region, specifically focusing on the Kumaon region. The study aims to understand the impact of altitude on the chemical composition of plants and its implications for ecological interactions and human health. Extensive field surveys were conducted across various altitudes, and plant samples were collected for chemical analysis. The results revealed significant variations in the chemical constituents of plants at different altitudes, including secondary metabolites such as alkaloids, flavonoids, and phenolic compounds. The study also identified specific altitude-dependent patterns, with certain compounds being more abundant or absent at particular altitudes. These variations in chemical constituents can be attributed to environmental factors such as temperature, humidity, and solar radiation, which change with altitude. The findings highlight the importance of considering altitude as a key factor in studying the chemical ecology of the Himalayan region. Understanding these variations can have significant implications for conservation efforts, pharmaceutical research, and traditional medicine practices in the region. Further research is needed to explore the ecological and physiological mechanisms underlying these altitude-related variations in chemical constituents.","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139279256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gourd bitter Grown mostly in India, China, and Southeast Asia, the tropical creeping plant known as or bitter melon. Its edible fruit is the primary reason for the plant's cultivation. Because of their bitter flavour, bitter gourds are not well-liked. The fruits of the Cucurbitaceae family plant Momordica charantia are a good source of a number of important nutrients. Over sixty phytomedicines, including blood purifiers, antioxidants, anticancer agents, and diabetes inhibitors, are present in the entire plant. In-depth information about the nutritional elements, different bioactive substances, and significant nutraceutical qualities of the bitter gourd plant in relation to diabetes are attempted to be provided in this review.
{"title":"Momordica charantia (bitter gourd), a potent antidiabetic phytomedicine","authors":"Anil Kumar Anil, Krishanu Samanta","doi":"10.46796/ijpc.v4i3.492","DOIUrl":"https://doi.org/10.46796/ijpc.v4i3.492","url":null,"abstract":"Gourd bitter Grown mostly in India, China, and Southeast Asia, the tropical creeping plant known as or bitter melon. Its edible fruit is the primary reason for the plant's cultivation. Because of their bitter flavour, bitter gourds are not well-liked. The fruits of the Cucurbitaceae family plant Momordica charantia are a good source of a number of important nutrients. Over sixty phytomedicines, including blood purifiers, antioxidants, anticancer agents, and diabetes inhibitors, are present in the entire plant. In-depth information about the nutritional elements, different bioactive substances, and significant nutraceutical qualities of the bitter gourd plant in relation to diabetes are attempted to be provided in this review.","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136010379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nanoparticles have become a significant component of advancing industries from technology to medicine and the environment. However, the synthesis of nanoparticles can impact their ability to function effectively within real-world applications, and this can cause negative consequences. This novel approach that utilizes processes such as regulation, control, clean-up, and remediation aims to increase the eco-friendly level of these essential particles. By reducing harmful by-products produced through the process of conventional nanoparticle synthesis, there will be less toxic unsustainable products created. The use of natural resources such as organic systems will aid in achieving the goal of creating a greener and more sustainable economy; however, it will require industrial assistance with the adoption of these alternative approaches. Metallic nanoparticles can be synthesized in a more sustainable and ‘green’ process through utilizing plant alternatives or biological materials such as bacteria, fungi, algae, and plant extracts. This greener approach can be a single step or ‘one pot’ process which requires a lower energy level than conventional processes. Another benefit is that this reduction method is more cost-efficient. Green-synthesized nanoparticles have clinical applications. When silver nanoparticles were treated against S. aureus, their antibacterial activity was at its peak. Nanoparticles used as drug carriers are highly stable, can incorporate both hydrophobic and hydrophilic substances, and can be delivered via a variety of routes also including oral application and inhalation.
{"title":"Green synthesis of nano particles from biodegradable waste extracts and their applications","authors":"Hari Krishna Ponduru, Chandra Sekhara Rao Gurubilli, Sowmya Mudunuru, Dileepu Kumar Banisetti","doi":"10.46796/ijpc.v4i3.462","DOIUrl":"https://doi.org/10.46796/ijpc.v4i3.462","url":null,"abstract":"Nanoparticles have become a significant component of advancing industries from technology to medicine and the environment. However, the synthesis of nanoparticles can impact their ability to function effectively within real-world applications, and this can cause negative consequences. This novel approach that utilizes processes such as regulation, control, clean-up, and remediation aims to increase the eco-friendly level of these essential particles. By reducing harmful by-products produced through the process of conventional nanoparticle synthesis, there will be less toxic unsustainable products created. The use of natural resources such as organic systems will aid in achieving the goal of creating a greener and more sustainable economy; however, it will require industrial assistance with the adoption of these alternative approaches. Metallic nanoparticles can be synthesized in a more sustainable and ‘green’ process through utilizing plant alternatives or biological materials such as bacteria, fungi, algae, and plant extracts. This greener approach can be a single step or ‘one pot’ process which requires a lower energy level than conventional processes. Another benefit is that this reduction method is more cost-efficient. Green-synthesized nanoparticles have clinical applications. When silver nanoparticles were treated against S. aureus, their antibacterial activity was at its peak. Nanoparticles used as drug carriers are highly stable, can incorporate both hydrophobic and hydrophilic substances, and can be delivered via a variety of routes also including oral application and inhalation.","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85138756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Warburgia species (Canellaceae) are traditionally used to treat a wide range of illnesses including stomach ache, diarrhea, abdominal pains, toothache, oral thrush, venereal diseases, cold and cough, fever, muscle pains, weak joints, skin diseases, malaria, parasitic infections and snake bite. Therapeutic properties of medicinal plants have been linked to the secondary metabolites which are biosynthesized by the plants. The aim of this study was to review the bioactivities and chemical composition of Warburgia ugandensis. The findings from this study show that extracts from the plant have antifungal, antibacterial, antiulcer, insect antifeedant, molluscicidal, antimycobacterial, antileishmanial and anti-plasmoidal effects. The most investigated part of W. ugandensis is the stem bark (22 articles) followed by leaves (15), root bark (6), seeds (2) and fruits (2). All parts the plant have important bioactivities. Sixty nine compounds have been reported from the plant including sesquiterpenes (43), flavonoids (15), lignanamides, and macrocyclic glycosides (10) and fatty acid (1) some of which have demonstrated different bioactivities. The drimane sesquiterpenes are the main class of sesquiterpenes in the plant. The Further investigation of the not well studied parts of the plant such as the flowers and fruits is recommended to determine their chemical composition and efficacy in disease management.
{"title":"Warburgia Ugandensis: A Review of Compounds and Bioactivity","authors":"Sylvia Opiyo","doi":"10.46796/ijpc.v4i2.457","DOIUrl":"https://doi.org/10.46796/ijpc.v4i2.457","url":null,"abstract":"Warburgia species (Canellaceae) are traditionally used to treat a wide range of illnesses including stomach ache, diarrhea, abdominal pains, toothache, oral thrush, venereal diseases, cold and cough, fever, muscle pains, weak joints, skin diseases, malaria, parasitic infections and snake bite. Therapeutic properties of medicinal plants have been linked to the secondary metabolites which are biosynthesized by the plants. The aim of this study was to review the bioactivities and chemical composition of Warburgia ugandensis. The findings from this study show that extracts from the plant have antifungal, antibacterial, antiulcer, insect antifeedant, molluscicidal, antimycobacterial, antileishmanial and anti-plasmoidal effects. The most investigated part of W. ugandensis is the stem bark (22 articles) followed by leaves (15), root bark (6), seeds (2) and fruits (2). All parts the plant have important bioactivities. Sixty nine compounds have been reported from the plant including sesquiterpenes (43), flavonoids (15), lignanamides, and macrocyclic glycosides (10) and fatty acid (1) some of which have demonstrated different bioactivities. The drimane sesquiterpenes are the main class of sesquiterpenes in the plant. The Further investigation of the not well studied parts of the plant such as the flowers and fruits is recommended to determine their chemical composition and efficacy in disease management.","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"113 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88207482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yimta Foutse Wandji, DarillN goubeyou Teukam, Anselme Michel Yawat Djogang, E. Djoko, F. Nguimatsia, D. Wouessidjewe
Our study took place in the Mifi Division, western Cameroon. The aim of this study was to identify the medicinal plants used in this Division. To carry out this survey, we used three methods to collect data: the field study, the comparative study and the interview of traditional healers from a pre-established list. We interviewed 15 traditional healers who were recommended to us by traditional chiefs, some churchmen and health workers. The interviews with 15 traditional healers yielded 39 plants in Bafoussam, 62 plants in Baleng, 20 plants in Bamougoum, 12 plants in Bapi and 16 plants in Badeng. There is a similarity in magnitude in the use of herbs between infectious, childhood and general traumatic pathologies respectively 17.54% and 15.78%. This represents the highest percentage of plant use in this Division. Gynaecological and obstetrical diseases come in third place with 14.03% of plants used. Then come the pathologies of the otorhinolaryngological system with a use of 10.52% of plants. Nervous system pathologies use 7.01%. Parasitic pathologies are treated by 5.20% of the plants. Dermatological and cardiovascular pathologies use 3.50% of plants respectively. Finally, viral and gastro-enteritis diseases are treated with 5.20% of plants each. The Plants species collected will certainly contribute to the production of the original traditional pharmacopoeia. The 149 plants mentioned above would form the basis for the development of improved traditional medicines for start.
{"title":"Ethno pharmacological survey in the MifiDivision (Cameroon)","authors":"Yimta Foutse Wandji, DarillN goubeyou Teukam, Anselme Michel Yawat Djogang, E. Djoko, F. Nguimatsia, D. Wouessidjewe","doi":"10.46796/ijpc.v4i2.451","DOIUrl":"https://doi.org/10.46796/ijpc.v4i2.451","url":null,"abstract":"Our study took place in the Mifi Division, western Cameroon. The aim of this study was to identify the medicinal plants used in this Division. To carry out this survey, we used three methods to collect data: the field study, the comparative study and the interview of traditional healers from a pre-established list. We interviewed 15 traditional healers who were recommended to us by traditional chiefs, some churchmen and health workers. The interviews with 15 traditional healers yielded 39 plants in Bafoussam, 62 plants in Baleng, 20 plants in Bamougoum, 12 plants in Bapi and 16 plants in Badeng. There is a similarity in magnitude in the use of herbs between infectious, childhood and general traumatic pathologies respectively 17.54% and 15.78%. This represents the highest percentage of plant use in this Division. Gynaecological and obstetrical diseases come in third place with 14.03% of plants used. Then come the pathologies of the otorhinolaryngological system with a use of 10.52% of plants. Nervous system pathologies use 7.01%. Parasitic pathologies are treated by 5.20% of the plants. Dermatological and cardiovascular pathologies use 3.50% of plants respectively. Finally, viral and gastro-enteritis diseases are treated with 5.20% of plants each. The Plants species collected will certainly contribute to the production of the original traditional pharmacopoeia. The 149 plants mentioned above would form the basis for the development of improved traditional medicines for start.","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"159 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83252768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chandra Sekhara Rao Gurubilli, Sowmya Mudunuru, S. G, V. G
Two new clinically active Schiff bases and their transition metal complexes were synthesized and studied by different spectroscopic and physicochemical methods like NMR, IR, UV-Visible, ESR, TGA, XRD, mass, elemental analysis, molar conductivity and magnetic character. Synthesized complexes and Schiff bases were assessed for invitro antituberculosis activity for Mycobacterium tuberculosis (ATCC–27294) and for antimicrobial activity against drug resistant ESBL (Extended Spectrum β-lactamase) and MBL (Metallo β-lactamase) producing microbial strains. The biological activity of Schiff base was found to improve in presence of transition metal ions. Among the studied metal complexes, copper complexes displayed superior biological activity against all of the microbial strains. Binary complexes of Cu(II), Ni(II), and Co (II) ions have been synthesized by reacting metal salts with a Schiff base, 2-((E)-(5-methylisoxazol-3-ylimino)methyl)-4-methoxyphenol (MIIMMP) in an alcoholic medium. All the metal complexes and schiff base have been characterized by using elemental analysis, IR, UV-VIS, 1H-NMR, 13C-NMR, Mass, ESR spectral data, magnetic moments, TG, and DTA studies. Based on the analytical, spectral data and molecular modeling studies, Ni (II) and Co (II) metal complexes have octahedral geometry, whereas Cu(II) complex has tetragonal geometry. The antimicrobial and cytotoxic activities of the Schiff base and its metal complexes were studied on bacteria, fungi, and human cervical carcinoma cells (HeLa).
{"title":"Synthesis, characterization, and biological evaluation of Ni, Co, and Cu Metal Complexes with Heterocyclic Compounds","authors":"Chandra Sekhara Rao Gurubilli, Sowmya Mudunuru, S. G, V. G","doi":"10.46796/ijpc.v4i2.445","DOIUrl":"https://doi.org/10.46796/ijpc.v4i2.445","url":null,"abstract":"Two new clinically active Schiff bases and their transition metal complexes were synthesized and studied by different spectroscopic and physicochemical methods like NMR, IR, UV-Visible, ESR, TGA, XRD, mass, elemental analysis, molar conductivity and magnetic character. Synthesized complexes and Schiff bases were assessed for invitro antituberculosis activity for Mycobacterium tuberculosis (ATCC–27294) and for antimicrobial activity against drug resistant ESBL (Extended Spectrum β-lactamase) and MBL (Metallo β-lactamase) producing microbial strains. The biological activity of Schiff base was found to improve in presence of transition metal ions. Among the studied metal complexes, copper complexes displayed superior biological activity against all of the microbial strains. Binary complexes of Cu(II), Ni(II), and Co (II) ions have been synthesized by reacting metal salts with a Schiff base, 2-((E)-(5-methylisoxazol-3-ylimino)methyl)-4-methoxyphenol (MIIMMP) in an alcoholic medium. All the metal complexes and schiff base have been characterized by using elemental analysis, IR, UV-VIS, 1H-NMR, 13C-NMR, Mass, ESR spectral data, magnetic moments, TG, and DTA studies. Based on the analytical, spectral data and molecular modeling studies, Ni (II) and Co (II) metal complexes have octahedral geometry, whereas Cu(II) complex has tetragonal geometry. The antimicrobial and cytotoxic activities of the Schiff base and its metal complexes were studied on bacteria, fungi, and human cervical carcinoma cells (HeLa).","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89642733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sowmya Mudunuru, Chandra Sekhara Rao Gurubilli, V. G, S. G
Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities.The first total synthesis and development of a variety of bioactive natural products have been accomplished by using carbohydrates as a chiral source. In addition, practically useful intermediates have been created, analogs of natural products have been prepared, their structure-activity relationships studied, and the large-scale preparations of medicinally useful compounds established.
{"title":"Synthesis of biologically active compounds derived from natural products","authors":"Sowmya Mudunuru, Chandra Sekhara Rao Gurubilli, V. G, S. G","doi":"10.46796/ijpc.v4i2.444","DOIUrl":"https://doi.org/10.46796/ijpc.v4i2.444","url":null,"abstract":"Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities.The first total synthesis and development of a variety of bioactive natural products have been accomplished by using carbohydrates as a chiral source. In addition, practically useful intermediates have been created, analogs of natural products have been prepared, their structure-activity relationships studied, and the large-scale preparations of medicinally useful compounds established.","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74207629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rubia cordifolia L. commonly known as Manjistha have been traditionally use as an Ayurvedic medicines for the treatment of various kind of diseases like dysentery, colic pain, blood purification, chest pains and related inflammatory conditions in India as well as at the various parts of the worlds. Beside its folk uses, the scientific studies revealing its application as effective anthelmintic agent is not studied scientifically yet. So, in search for the effective anthelmintic agent, R. cordifolia roots were investigated for in-vitro anthelmintic activity. In this study, the petroleum ether, chloroform, acetone, ethanol and aqueous extracts were tested against adult earthworms (Pheretima posthuma) along with phytochemical screening to determine the most possible constituents responsible for the activity. In this study we found that, the petroleum ether and chloroform extract had finest activity against adult earthworms as compared to other extracts. Said in-vitro anthelmintic activity was proposed due to its richness of variety of chemical constituents like alkaloids, steroids, flavonoids, terpenoids, tannins and anthraquinone glycosides.
{"title":"In-vitro anthelmintic activity and phytochemical screening of Rubia cordifolia L. root extracts","authors":"","doi":"10.46796/ijpc.v4i1.419","DOIUrl":"https://doi.org/10.46796/ijpc.v4i1.419","url":null,"abstract":"Rubia cordifolia L. commonly known as Manjistha have been traditionally use as an Ayurvedic medicines for the treatment of various kind of diseases like dysentery, colic pain, blood purification, chest pains and related inflammatory conditions in India as well as at the various parts of the worlds. Beside its folk uses, the scientific studies revealing its application as effective anthelmintic agent is not studied scientifically yet. So, in search for the effective anthelmintic agent, R. cordifolia roots were investigated for in-vitro anthelmintic activity. In this study, the petroleum ether, chloroform, acetone, ethanol and aqueous extracts were tested against adult earthworms (Pheretima posthuma) along with phytochemical screening to determine the most possible constituents responsible for the activity. In this study we found that, the petroleum ether and chloroform extract had finest activity against adult earthworms as compared to other extracts. Said in-vitro anthelmintic activity was proposed due to its richness of variety of chemical constituents like alkaloids, steroids, flavonoids, terpenoids, tannins and anthraquinone glycosides. ","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88132373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this review article determines the different analytical methods for the quantitative establishment of Dasatinib by using HPLC, HPLCMS, HPLC-UV, LC-MS/MS. Pharmaceutical analytical method development of Dasatinib requires valid analytical procedures for quantitative and qualitative analysis in Pharmaceuticals dosage formulations and human serum. This assessment explains that the superiority of the HPLC/LC-MS methods reviewed is based on the quantitative analysis of drugs in formulations, (API), biological fluids such as serum and plasma.
{"title":"Overall review on analytical method development and validation of Dasatinib","authors":"Mohana Vamsi Nuli, Vijay Kumar Rekulapally","doi":"10.46796/ijpc.v4i1.432","DOIUrl":"https://doi.org/10.46796/ijpc.v4i1.432","url":null,"abstract":"In this review article determines the different analytical methods for the quantitative establishment of Dasatinib by using HPLC, HPLCMS, HPLC-UV, LC-MS/MS. Pharmaceutical analytical method development of Dasatinib requires valid analytical procedures for quantitative and qualitative analysis in Pharmaceuticals dosage formulations and human serum. This assessment explains that the superiority of the HPLC/LC-MS methods reviewed is based on the quantitative analysis of drugs in formulations, (API), biological fluids such as serum and plasma.","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75266712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A significant portion of recent papers is in the field of Mercapto substituted Triazole moiety received considerable attention in the literature.Characterization and Antibacterial activity against important medically Gram positive Bacteria likely Actinomyces, Clostridium, Mycobacterium, Strptococci, Staphylococci and Nocardia.Triazole is a class of N-Bridged Heterocyclic compounds especially in Chemotherapy. Triazole moiety seems to be very small but 1,2,4-Triazole derivatives have wide range of potential antibacterial activities against drug-resistant pathogens.Hybridization shows a high potential to develop novel drugs,reduce toxicity,and improve Pharmacokinetic profiles.More effective antibacterial studies might be obtained by the hybridization of 1,2,4-Triazole mercapto moiety. A number of clinically effective antibacterial drugs become more effective. Therefore, we shed, herein, more light on novel synthetic drug and its antibacterial activity.
{"title":"Synthesis, Characterization, and Biological Evaluation Of [1,2,4 ]-Triazole-3yl]Sulfanyl Acetamide Derivative","authors":"Santanu Kumar Hotta, S. Rout, Anjan Kumar","doi":"10.46796/ijpc.v4i1.429","DOIUrl":"https://doi.org/10.46796/ijpc.v4i1.429","url":null,"abstract":"A significant portion of recent papers is in the field of Mercapto substituted Triazole moiety received considerable attention in the literature.Characterization and Antibacterial activity against important medically Gram positive Bacteria likely Actinomyces, Clostridium, Mycobacterium, Strptococci, Staphylococci and Nocardia.Triazole is a class of N-Bridged Heterocyclic compounds especially in Chemotherapy. Triazole moiety seems to be very small but 1,2,4-Triazole derivatives have wide range of potential antibacterial activities against drug-resistant pathogens.Hybridization shows a high potential to develop novel drugs,reduce toxicity,and improve Pharmacokinetic profiles.More effective antibacterial studies might be obtained by the hybridization of 1,2,4-Triazole mercapto moiety. A number of clinically effective antibacterial drugs become more effective. Therefore, we shed, herein, more light on novel synthetic drug and its antibacterial activity.","PeriodicalId":14190,"journal":{"name":"International Journal of Pharmacognosy and Chemistry","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84962658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：