Background: Ovulatory failure in females being the cause in 20-30% of infertility, the inability to conceive naturally or to carry out a pregnancy to full term or to deliver a healthy baby after trying for 1 year. Availability of ovulation inducing medicines and assisted reproductive technologies does not answer enough solution leading to search for new avenues in alternative therapies. Ovulatory effects of the Aloe Vera Gel extract (AVG) from Aloe Barbadensis Mill have been demonstrated in Letrozole induced PCOD rat models. Hence this study to assess the ovulatory effect of AVG extract using increase in parabasal cells in vaginal smear as the indirect indicator using mature female rabbits is planned.Methodology: With the approval of Institutional Research and Animal ethics committee six mature non pregnant rabbit does weighing 2-2.5 kg showing ovulatory failure in each group received saline as control or AVG extract only 150mg/kg orally for 28 days or followed by hCG 120 I.U I.V on 29th day or only hCG. Leishman stained vaginal smears taken on 0day, 1st week, 4th week and 6th week for first 3 groups and 48, 72 and 120 Hours after hCG for IVth group were examined for superficial and parabasal cells under 100x magnification. The data was analyzed with two way ANOVA and Bon-ferrani tests for statistical significance of p value <0.05.Results: Statistically significant decrease in superficial cells percentage (p-<0.001) and proportionate increase in parabasal cells percentages (p-<0.001) were observed in does received aloe vera alone and also hCG on 4th & 6th week and 72 Hours after receiving only HCG.(P-value of < 0.01).Conclusion: AVG of 150mg/kg /day for 28 days has shown ovulatory effect like HCG. Further studies supported by hormonal assays and HPE or USG for confirmation is suggested.
{"title":"Ovulatory Effect of Aloe Barbadensis Mill in Mature New Zealand Rabbit Does","authors":"R. Saravanan, V. Bavani","doi":"10.7439/IJPR.V7I12.4469","DOIUrl":"https://doi.org/10.7439/IJPR.V7I12.4469","url":null,"abstract":"Background: Ovulatory failure in females being the cause in 20-30% of infertility, the inability to conceive naturally or to carry out a pregnancy to full term or to deliver a healthy baby after trying for 1 year. Availability of ovulation inducing medicines and assisted reproductive technologies does not answer enough solution leading to search for new avenues in alternative therapies. Ovulatory effects of the Aloe Vera Gel extract (AVG) from Aloe Barbadensis Mill have been demonstrated in Letrozole induced PCOD rat models. Hence this study to assess the ovulatory effect of AVG extract using increase in parabasal cells in vaginal smear as the indirect indicator using mature female rabbits is planned.Methodology: With the approval of Institutional Research and Animal ethics committee six mature non pregnant rabbit does weighing 2-2.5 kg showing ovulatory failure in each group received saline as control or AVG extract only 150mg/kg orally for 28 days or followed by hCG 120 I.U I.V on 29th day or only hCG. Leishman stained vaginal smears taken on 0day, 1st week, 4th week and 6th week for first 3 groups and 48, 72 and 120 Hours after hCG for IVth group were examined for superficial and parabasal cells under 100x magnification. The data was analyzed with two way ANOVA and Bon-ferrani tests for statistical significance of p value <0.05.Results: Statistically significant decrease in superficial cells percentage (p-<0.001) and proportionate increase in parabasal cells percentages (p-<0.001) were observed in does received aloe vera alone and also hCG on 4th & 6th week and 72 Hours after receiving only HCG.(P-value of < 0.01).Conclusion: AVG of 150mg/kg /day for 28 days has shown ovulatory effect like HCG. Further studies supported by hormonal assays and HPE or USG for confirmation is suggested.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"46 1","pages":"240-247"},"PeriodicalIF":0.0,"publicationDate":"2017-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72623998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Khan, M. Khan, Aijaz Ahmad Patloo, Mohammad Arif Makhdoomi, S. Dar
Background: Cyclophosphamide is widely used in the treatment of various neoplastic diseases and diseases associated with altered immunity. Higher doses used for longer duration effects many organs like urinary bladder, lungs, liver, heart and male reproductive organs. Methods: To study the effect of cyclophosphamide on the micro anatomy of epididymis, sixty eight Albino rats were taken and divided into three groups, group A (control group) of 20 animals, were fed with routine diet, group B (low dose group) of 24 animals, were given cyclophosphamide at the dose of 0.5 mg/100 gms in addition to the routine diet and group C (high dose group) of 24 animals, were given high dose of cyclophosphamide at the dose of 0.7 mg/100 gms of weight of animal in addition to the routine diet. The animals were sacrificed at intervals of 3, 6, 9 and 12 weeks, sections of the tissue from the epididymis were prepared and stained with Haematoxylin and Eosin stain. Results: In both low dose and high dose groups there was no apparent histological change at 3 weeks of drug administration, however there were absent sperm whorls in some of the tubules of the epididymis of both low dose and high dose groups at this stage. At 6 weeks there was increase in the number of clear cells in the tubules of epididymis of both the groups. While as at 9 weeks there were some atrophic changes in the tubules of group C rats. Conclusion: In present study we observed certain histological changes in the epididymis of cyclophosphamide treated albino rats. These were in the form of absent sperms, increase in number of clear cells, increase in peritubular space and atrophic changes.
{"title":"Histological Changes in Epididymis of Albino Rats by Graded Doses of Cyclophosphamide","authors":"J. Khan, M. Khan, Aijaz Ahmad Patloo, Mohammad Arif Makhdoomi, S. Dar","doi":"10.7439/IJPR.V7I12.4539","DOIUrl":"https://doi.org/10.7439/IJPR.V7I12.4539","url":null,"abstract":"Background: Cyclophosphamide is widely used in the treatment of various neoplastic diseases and diseases associated with altered immunity. Higher doses used for longer duration effects many organs like urinary bladder, lungs, liver, heart and male reproductive organs. Methods: To study the effect of cyclophosphamide on the micro anatomy of epididymis, sixty eight Albino rats were taken and divided into three groups, group A (control group) of 20 animals, were fed with routine diet, group B (low dose group) of 24 animals, were given cyclophosphamide at the dose of 0.5 mg/100 gms in addition to the routine diet and group C (high dose group) of 24 animals, were given high dose of cyclophosphamide at the dose of 0.7 mg/100 gms of weight of animal in addition to the routine diet. The animals were sacrificed at intervals of 3, 6, 9 and 12 weeks, sections of the tissue from the epididymis were prepared and stained with Haematoxylin and Eosin stain. Results: In both low dose and high dose groups there was no apparent histological change at 3 weeks of drug administration, however there were absent sperm whorls in some of the tubules of the epididymis of both low dose and high dose groups at this stage. At 6 weeks there was increase in the number of clear cells in the tubules of epididymis of both the groups. While as at 9 weeks there were some atrophic changes in the tubules of group C rats. Conclusion: In present study we observed certain histological changes in the epididymis of cyclophosphamide treated albino rats. These were in the form of absent sperms, increase in number of clear cells, increase in peritubular space and atrophic changes.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"10 1","pages":"236-239"},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84828493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Swaroopa, V. Reddy, Mallapu Koshma, Y. Sudharani, S. J. Basha, T. N. Adithya
Medicinal plants have been proposed as rich yet unexploited potential sources for anti-diabetic drugs, even though used since ancient times for the treatment of diabetes mellitus. Many of the synthetic drugs were discovered either directly or indirectly from the plant source. The present study reviews of plants having anti diabetic property. Although many plants are recommendation, further pharmacological and chemical research should be done to elucidate the exact mechanism of hypoglycaemic activity.
{"title":"Review on Antidiabetic Activity on Medicinal Plants","authors":"P. Swaroopa, V. Reddy, Mallapu Koshma, Y. Sudharani, S. J. Basha, T. N. Adithya","doi":"10.7439/IJPR.V7I12.4457","DOIUrl":"https://doi.org/10.7439/IJPR.V7I12.4457","url":null,"abstract":"Medicinal plants have been proposed as rich yet unexploited potential sources for anti-diabetic drugs, even though used since ancient times for the treatment of diabetes mellitus. Many of the synthetic drugs were discovered either directly or indirectly from the plant source. The present study reviews of plants having anti diabetic property. Although many plants are recommendation, further pharmacological and chemical research should be done to elucidate the exact mechanism of hypoglycaemic activity.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"27 1","pages":"230-235"},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80719819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective : The objective of the present study was to evaluate the Anti-obesity activity of Garuga pinnata Roxb in high fat diet induced rats. Materials and Methods: Gall part of leaves of Garuga pinnata were collected, dried, powdered and extracted with ethanol (70%) to get Ethanolic extract of Garuga pinnata (EGP). Rats were divided into 5 groups in high fat diet induced model. Normal control animals were fed with the rat chow diet and all other grouped rats were fed with high fat diet, Standard group was treated with Orlistat (10 mg/kg, p.o.) and rats of test groups were treated with the EGP (100 and 200 mg/kg, p.o.) for 4 weeks. Anthropometric parameters were measured once in a week and lipid profile and antioxidant parameters were measured on the 29 th day. Histopathology of kidney and liver was studied. Results: Body weight and BMI was significantly reduced in the test groups (100 and 200 mg/kg, p.o.). TG, TC, LDL-C, VLDL-C, LPO levels were reduced and HDL-C and anti-oxidants were elevated in both test groups as compare to disease control animals. Histopathology of liver showed protection against fat accumulation in Ethanolic extract of Garuga pinnata (100 and 200 mg/kg, p.o.). Conclusion: In the light of finding and discussion, it was concluded that Ethanolic extract of Garuga pinnata (100 and 200 mg/kg) may have anti-obesity in high fat diet induced rats and showed preventive effect against fat accumulation in liver.
{"title":"Evaluation of anti-obesity activity of Garuga pinnata Roxb. in high fat diet induced rats","authors":"Sohel Khan, Alkesh Patel, Samir K. Shah","doi":"10.7439/IJPR.V7I11.4242","DOIUrl":"https://doi.org/10.7439/IJPR.V7I11.4242","url":null,"abstract":"Objective : The objective of the present study was to evaluate the Anti-obesity activity of Garuga pinnata Roxb in high fat diet induced rats. Materials and Methods: Gall part of leaves of Garuga pinnata were collected, dried, powdered and extracted with ethanol (70%) to get Ethanolic extract of Garuga pinnata (EGP). Rats were divided into 5 groups in high fat diet induced model. Normal control animals were fed with the rat chow diet and all other grouped rats were fed with high fat diet, Standard group was treated with Orlistat (10 mg/kg, p.o.) and rats of test groups were treated with the EGP (100 and 200 mg/kg, p.o.) for 4 weeks. Anthropometric parameters were measured once in a week and lipid profile and antioxidant parameters were measured on the 29 th day. Histopathology of kidney and liver was studied. Results: Body weight and BMI was significantly reduced in the test groups (100 and 200 mg/kg, p.o.). TG, TC, LDL-C, VLDL-C, LPO levels were reduced and HDL-C and anti-oxidants were elevated in both test groups as compare to disease control animals. Histopathology of liver showed protection against fat accumulation in Ethanolic extract of Garuga pinnata (100 and 200 mg/kg, p.o.). Conclusion: In the light of finding and discussion, it was concluded that Ethanolic extract of Garuga pinnata (100 and 200 mg/kg) may have anti-obesity in high fat diet induced rats and showed preventive effect against fat accumulation in liver.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"73 1","pages":"221-229"},"PeriodicalIF":0.0,"publicationDate":"2017-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80509898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yogesh S. Chaudhari, I. Ansari, V. Kanase, S. Rathod
Guazuma tomentosa. L is belonging to the family Sterculiaceae and commonly called Bastard cedarain Sanskrit Rudraakshi. Medium-sized tree that grows up to 20 m height. Guazuma tomentosa is indigenous to tropical america on both continents and found throughout the amazon rainforest. Guazuma is called guasima or guacima in mexico, where it has a very long history of indigenous use. Ethnobotanical uses of guazuma tomentosa . Antidysenteric, antibacterial, anti-inflammatory, antifungal, astringent, antimicrobial, diaphoretic, depurative, febrifuge, hepatoprotective, emollient, pectoral, stomachic, refrigerant, sudorific and styptic. Phytochemically plant contains steroids, fatty acids, flavanoids, glycosides, tannins, carbohydrates, mucilage. Guazuma tomentosa holds a place in herbal medicine systems in many tropical countries. Guazuma tomentosa has long history of effective uses in herbal medicine propelling. Researchers to begin studied its properties and activities in the laboratory. It has been the subjectof numerous research since. In the first study examined using various in-vitro and in-vivo research study onexperimental animal models (rats, rabbits, guinea pigs, cats and insects). Pharmacological evaluation on plant demonstrate till date are anti-diabetic action, anti-hypertensive, anti-microbial action, anti-oxidant, antiulceraction, hair growth promoter, weight loss agent. The plant appears to have a broad spectrum of activity on several ailments.
{"title":"Evaluation of phytochemical and pharmacological profile of Guazuma tomentosa L.","authors":"Yogesh S. Chaudhari, I. Ansari, V. Kanase, S. Rathod","doi":"10.7439/ijpr.v7i11.4243","DOIUrl":"https://doi.org/10.7439/ijpr.v7i11.4243","url":null,"abstract":"Guazuma tomentosa. L is belonging to the family Sterculiaceae and commonly called Bastard cedarain Sanskrit Rudraakshi. Medium-sized tree that grows up to 20 m height. Guazuma tomentosa is indigenous to tropical america on both continents and found throughout the amazon rainforest. Guazuma is called guasima or guacima in mexico, where it has a very long history of indigenous use. Ethnobotanical uses of guazuma tomentosa . Antidysenteric, antibacterial, anti-inflammatory, antifungal, astringent, antimicrobial, diaphoretic, depurative, febrifuge, hepatoprotective, emollient, pectoral, stomachic, refrigerant, sudorific and styptic. Phytochemically plant contains steroids, fatty acids, flavanoids, glycosides, tannins, carbohydrates, mucilage. Guazuma tomentosa holds a place in herbal medicine systems in many tropical countries. Guazuma tomentosa has long history of effective uses in herbal medicine propelling. Researchers to begin studied its properties and activities in the laboratory. It has been the subjectof numerous research since. In the first study examined using various in-vitro and in-vivo research study onexperimental animal models (rats, rabbits, guinea pigs, cats and insects). Pharmacological evaluation on plant demonstrate till date are anti-diabetic action, anti-hypertensive, anti-microbial action, anti-oxidant, antiulceraction, hair growth promoter, weight loss agent. The plant appears to have a broad spectrum of activity on several ailments.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"8 1","pages":"214-220"},"PeriodicalIF":0.0,"publicationDate":"2017-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73047385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cassime Tiémoko, A. Bidie, Gervais Melaine M’boh, A. Djaman
The objective of this investigation is to valorizeArabusta, an hybrid coffee, by testing it on the cardiac and biochemical parameters of rats made hypertensive to adrenaline.The present study was carried out on 32 rats divided into 2 lots: one control (4) and one test (28). After induction of adrenaline hypertension in the test batch, the curative effect of the coffee extract was evaluated at the different doses (200 and 400 mg / kg). At the end of the experiment, the cardiovascular parameters were measured and blood samples were taken for the determination of the various parameters.Our results showed that the treatment of hypertensive rats with the extract at the dose of 400 mg / kg exerted an antihypertensive effect by a significant decrease (P <0.05) of the cardiovascular parameters (-31.2 mmHg for SBP and -31 mmHg for DBP). The beneficial effects of the extract on blood pressure were accompanied by a reduction in oxidative stress.Arabusta coffee could be recommended as a new antihypertensive food supplement because of its remarkable action on some risk factors for the onset of the disease.
{"title":"Effects of Arabusta coffee on the cardiovascular and biochemical parameters in hypertensive rats","authors":"Cassime Tiémoko, A. Bidie, Gervais Melaine M’boh, A. Djaman","doi":"10.7439/IJPR.V7I10.4437","DOIUrl":"https://doi.org/10.7439/IJPR.V7I10.4437","url":null,"abstract":"The objective of this investigation is to valorizeArabusta, an hybrid coffee, by testing it on the cardiac and biochemical parameters of rats made hypertensive to adrenaline.The present study was carried out on 32 rats divided into 2 lots: one control (4) and one test (28). After induction of adrenaline hypertension in the test batch, the curative effect of the coffee extract was evaluated at the different doses (200 and 400 mg / kg). At the end of the experiment, the cardiovascular parameters were measured and blood samples were taken for the determination of the various parameters.Our results showed that the treatment of hypertensive rats with the extract at the dose of 400 mg / kg exerted an antihypertensive effect by a significant decrease (P <0.05) of the cardiovascular parameters (-31.2 mmHg for SBP and -31 mmHg for DBP). The beneficial effects of the extract on blood pressure were accompanied by a reduction in oxidative stress.Arabusta coffee could be recommended as a new antihypertensive food supplement because of its remarkable action on some risk factors for the onset of the disease.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"159 1","pages":"208-213"},"PeriodicalIF":0.0,"publicationDate":"2017-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76624084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The activity of the compound 8,9-dihydroxy-1,5,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin-3(2H)-one (trolline) isolated from Mirabilis jalapa against selected enteropathogenic bacteria is being investigated. Clinical isolates of Streptococcus feacalis, Shigella dysenteriae, Salmonella typhi, Bacillus cereus, Eschericia coli and Vibrio cholera were screened for susceptibility to serial dilutions of an initial stock concentration of 100g/ml (456.62M) of the compound. Zones of inhibition on well labeled sub-cultured agar plates were measured in millimeters and recorded. The minimum inhibitory concentration (MIC) was determined using broth dilution methods while the least concentration that killed the bacterial cells was recorded as the minimum bactericidal concentration (MBC). S. typhi, B. cereus, E. coli and S. dysenteriae were susceptible to the test compound, with zones of inhibition measuring 32mm for S. dysenteriae. MIC of 57M was observed for S. typhi, B. cereus and S. dysenteriae while bactericidal concentration (MBC) ranged between 114-228M for all susceptible organisms tested. In conclusion, the in-vitro assessment of trolline shows the compound possess bioactive properties against diarrhea causing enteropathogenic bacteria.
{"title":"Bactericidal effects of 8,9-dihydroxy-1,5,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin- 3(2H)-one (Trolline) on selected entero-pathogenic bacteria","authors":"M. Sadiq, S. AbdullahiMikailu","doi":"10.7439/IJPR.V7I10.4038","DOIUrl":"https://doi.org/10.7439/IJPR.V7I10.4038","url":null,"abstract":"The activity of the compound 8,9-dihydroxy-1,5,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin-3(2H)-one (trolline) isolated from Mirabilis jalapa against selected enteropathogenic bacteria is being investigated. Clinical isolates of Streptococcus feacalis, Shigella dysenteriae, Salmonella typhi, Bacillus cereus, Eschericia coli and Vibrio cholera were screened for susceptibility to serial dilutions of an initial stock concentration of 100g/ml (456.62M) of the compound. Zones of inhibition on well labeled sub-cultured agar plates were measured in millimeters and recorded. The minimum inhibitory concentration (MIC) was determined using broth dilution methods while the least concentration that killed the bacterial cells was recorded as the minimum bactericidal concentration (MBC). S. typhi, B. cereus, E. coli and S. dysenteriae were susceptible to the test compound, with zones of inhibition measuring 32mm for S. dysenteriae. MIC of 57M was observed for S. typhi, B. cereus and S. dysenteriae while bactericidal concentration (MBC) ranged between 114-228M for all susceptible organisms tested. In conclusion, the in-vitro assessment of trolline shows the compound possess bioactive properties against diarrhea causing enteropathogenic bacteria.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"15 1","pages":"203-207"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82553875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Effect of methanolic extract of Cissampelos pareira (CPME) (200, 400 mg/kg, PO) was studied on acetic acid and DSS induced colitis in rats and mice respectively. Montelukast (20 mg/kg, PO) was used as a Standard drug. At the end of experiment various parameters like scoring for colon, Disease activity index (DAI) which took into account body weight, stool consistency, gross bleeding, Alkaline phosphate (ALP), Erythrocyte Sedimentation Rate (ESR), white blood cell (WBC) count and myeloperoxydase (MPO) activity were measured. Treatment with CP (200,400 mg/kg, PO) decreased significantly macroscopic damage in both models. Histological analysis showed that both doses of the extract improved the microscopic structure and preserved some areas of the colonic mucosa structure. MPO, as a marker of neutrophils infiltration was decreased in a dose-dependent way. In addition DAI, WBC count, ESR and ALP activity also significantly decreases in both doses of CP (p < 0.05, p < 0.01 respectively) in both models. So, from our study we found that CP exerts marked protective effects in acute experimental colitis and may be used clinically in treatment of IBD. This protective effect may be due to the regulations of the productions and an expression of inflammatory mediators.
{"title":"Effect of methanolic extract of Cissampelos pareira on Acetic acid and Dextran Sodium Sulphate (DSS) induced inflammatory bowel disease (IBD) in albino rats and mice","authors":"Tanvi Desai, Supriya Das","doi":"10.7439/IJPR.V7I10.4261","DOIUrl":"https://doi.org/10.7439/IJPR.V7I10.4261","url":null,"abstract":"Effect of methanolic extract of Cissampelos pareira (CPME) (200, 400 mg/kg, PO) was studied on acetic acid and DSS induced colitis in rats and mice respectively. Montelukast (20 mg/kg, PO) was used as a Standard drug. At the end of experiment various parameters like scoring for colon, Disease activity index (DAI) which took into account body weight, stool consistency, gross bleeding, Alkaline phosphate (ALP), Erythrocyte Sedimentation Rate (ESR), white blood cell (WBC) count and myeloperoxydase (MPO) activity were measured. Treatment with CP (200,400 mg/kg, PO) decreased significantly macroscopic damage in both models. Histological analysis showed that both doses of the extract improved the microscopic structure and preserved some areas of the colonic mucosa structure. MPO, as a marker of neutrophils infiltration was decreased in a dose-dependent way. In addition DAI, WBC count, ESR and ALP activity also significantly decreases in both doses of CP (p < 0.05, p < 0.01 respectively) in both models. So, from our study we found that CP exerts marked protective effects in acute experimental colitis and may be used clinically in treatment of IBD. This protective effect may be due to the regulations of the productions and an expression of inflammatory mediators.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"27 1","pages":"196-202"},"PeriodicalIF":0.0,"publicationDate":"2017-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80693541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. J. Basha, V. Reddy, Y. Sudharani, Mallapu Koshma, G. Hanumanthu, S. Dadakhalandar
Terminalia chebula Retz (Combretaceae) is a medicinal plant widely distributed throughout India , Buma, and Srilanka. Many Indian plants have been used from time immemorial to treat various diseases and infections in traditional medicinal systems. This plant commonly used in traditional systems of medicinal in India sub-constituent. Terminalia chebula is called as King of medicine in Tibet and is always listed at the top of the list in Ayurvedic material medica due to its extraordinary power of healing. This review attempts to summarize the various pharmacological and biochemical studies on Terminalia chebula which gives a wide knowledge about the herb and their importance in personal health care and hygiene.
{"title":"A review on Terminalia chebula","authors":"S. J. Basha, V. Reddy, Y. Sudharani, Mallapu Koshma, G. Hanumanthu, S. Dadakhalandar","doi":"10.7439/ijpr.v7i10.4431","DOIUrl":"https://doi.org/10.7439/ijpr.v7i10.4431","url":null,"abstract":"Terminalia chebula Retz (Combretaceae) is a medicinal plant widely distributed throughout India , Buma, and Srilanka. Many Indian plants have been used from time immemorial to treat various diseases and infections in traditional medicinal systems. This plant commonly used in traditional systems of medicinal in India sub-constituent. Terminalia chebula is called as King of medicine in Tibet and is always listed at the top of the list in Ayurvedic material medica due to its extraordinary power of healing. This review attempts to summarize the various pharmacological and biochemical studies on Terminalia chebula which gives a wide knowledge about the herb and their importance in personal health care and hygiene.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"187 1","pages":"187-191"},"PeriodicalIF":0.0,"publicationDate":"2017-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83457314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Physico- chemical analysis showed the details of extractive portion of the plant and ash composition. The entire plant powder of Ludwigia perennis shows, Soluble in ethanol (89.35 %), Water soluble ash (56.7 %), and Moisture.
{"title":"Physicochemical analysis of the entire plant powder Ludwigia perennis L. by using different solvents","authors":"M. Sharmila, M. Rajeswari, Geetha Dh","doi":"10.7439/IJPR.V7I10.4416","DOIUrl":"https://doi.org/10.7439/IJPR.V7I10.4416","url":null,"abstract":"Physico- chemical analysis showed the details of extractive portion of the plant and ash composition. The entire plant powder of Ludwigia perennis shows, Soluble in ethanol (89.35 %), Water soluble ash (56.7 %), and Moisture.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"49 1","pages":"192-195"},"PeriodicalIF":0.0,"publicationDate":"2017-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73351785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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