Pub Date : 2019-02-01DOI: 10.18052/WWW.SCIPRESS.COM/IJPPE.12.12
Queen Saikia, M. Das, A. Saikia
Exceeding iron levels in the body get accumulated in the liver and other vital organs that induce oxidative stress in the affected areas , which is clinically diagnosed as “iron overload”. Present study was undertaken to investigate the role of Phlogacanthus thyrsiflorus Nees, an endemic species of North-east India, in ameliorating such diseased conditions. Our results indicate that the methanolic leaf extract of Phlogacanthus thyrsiflorus (PTME) exhibits excellent iron chelation and antioxidant activities in dose dependent manner in vitro. To understand the in vivo conditions, thirty six mice were divided into six groups which were treated with differing doses of PTME. Levels of serum markers ALT and AST significantly elevates during diseased conditions but PTME treated mice have shown a marked decrease in the group (S200) by 39.24 and 17.24%. On the contrary lowering levels of liver antioxidant enzymes (GST, GSH, SOD and CAT) indicates stress. But 200mg/kg b.w of PTME treated groups restored the enzyme to optimum levels. Morphological changes were observed through histopathological analysis of liver tissues and we found significant differences in them . PTME was found to be completely nontoxic in the in vivo treatment, suggesting its feasibility as a safe oral drug. The above study suggests that PTME contributed to its free radical scavenging and iron chelation activity; however, further studies are required for the assessment of the phytoconstituents and the pathways through which it act to treat iron-overload diseases.
{"title":"Hepatoprotective Role of Phlogacanthus thyrsiflorus Nees as a Potential Iron Chelating Drug","authors":"Queen Saikia, M. Das, A. Saikia","doi":"10.18052/WWW.SCIPRESS.COM/IJPPE.12.12","DOIUrl":"https://doi.org/10.18052/WWW.SCIPRESS.COM/IJPPE.12.12","url":null,"abstract":"Exceeding iron levels in the body get accumulated in the liver and other vital organs that induce oxidative stress in the affected areas , which is clinically diagnosed as “iron overload”. Present study was undertaken to investigate the role of Phlogacanthus thyrsiflorus Nees, an endemic species of North-east India, in ameliorating such diseased conditions. Our results indicate that the methanolic leaf extract of Phlogacanthus thyrsiflorus (PTME) exhibits excellent iron chelation and antioxidant activities in dose dependent manner in vitro. To understand the in vivo conditions, thirty six mice were divided into six groups which were treated with differing doses of PTME. Levels of serum markers ALT and AST significantly elevates during diseased conditions but PTME treated mice have shown a marked decrease in the group (S200) by 39.24 and 17.24%. On the contrary lowering levels of liver antioxidant enzymes (GST, GSH, SOD and CAT) indicates stress. But 200mg/kg b.w of PTME treated groups restored the enzyme to optimum levels. Morphological changes were observed through histopathological analysis of liver tissues and we found significant differences in them . PTME was found to be completely nontoxic in the in vivo treatment, suggesting its feasibility as a safe oral drug. The above study suggests that PTME contributed to its free radical scavenging and iron chelation activity; however, further studies are required for the assessment of the phytoconstituents and the pathways through which it act to treat iron-overload diseases.","PeriodicalId":14237,"journal":{"name":"International Journal of Pharmacology, Phytochemistry and Ethnomedicine","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89391955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.18052/WWW.SCIPRESS.COM/IJPPE.12.1
E. Popa, F. Zugun-Eloae, M. Zlei, M. Traian, A. Bacușcă, A. Popa, A. Coman
The pathogeny of the metabolic syndrome (MetS ) is not fully elucidated, but a link between visceral obesity and the increase of the proinflammatory response was proven. Atherosclerosis, perceived as a metabolic complication, draws attention to the peroxisome proliferator-activated receptors- alpha (PPARα). PPARα receptors are transcription factors involved in lipid metabolism, inflammation and atheromatosis. Hence, it interferes in the pathogeny of cardiovascular diseases and other chronic diseases too (neurological, psychical, neoplasical). The study of the expression of PPARα and its modulation on different level may be beneficial in the treatment of metabolic syndrome, intervening in the modulation of another proinflammatory factors.
{"title":"Peroxisome Proliferator-Activated Receptors - Alpha in Chronic Inflammation - Mini-Review","authors":"E. Popa, F. Zugun-Eloae, M. Zlei, M. Traian, A. Bacușcă, A. Popa, A. Coman","doi":"10.18052/WWW.SCIPRESS.COM/IJPPE.12.1","DOIUrl":"https://doi.org/10.18052/WWW.SCIPRESS.COM/IJPPE.12.1","url":null,"abstract":"The pathogeny of the metabolic syndrome (MetS ) is not fully elucidated, but a link between visceral obesity and the increase of the proinflammatory response was proven. Atherosclerosis, perceived as a metabolic complication, draws attention to the peroxisome proliferator-activated receptors- alpha (PPARα). PPARα receptors are transcription factors involved in lipid metabolism, inflammation and atheromatosis. Hence, it interferes in the pathogeny of cardiovascular diseases and other chronic diseases too (neurological, psychical, neoplasical). The study of the expression of PPARα and its modulation on different level may be beneficial in the treatment of metabolic syndrome, intervening in the modulation of another proinflammatory factors.","PeriodicalId":14237,"journal":{"name":"International Journal of Pharmacology, Phytochemistry and Ethnomedicine","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86878186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.18052/WWW.SCIPRESS.COM/IJPPE.12.23
M. Ayeni, J. Kayode
Inventory of plant species whose barks were sold in markets located in two local government areas of Kaduna State, Nigeria was carried out in this study. Three markets were selected randomly from each of the two Local Government Areas of the study area. In each market, 10 medicinal plant vendors and 10 respondents were randomly selected and interviewed with the aid of semi structure questionnaire matrix. Plants whose stem barks were of medicinal values were identified; their mode of preparations and utilizations were documented. The respondents were diverse and cut across socioeconomic classification. Respondents’ consciousness was linked to oral transfer of the indigenous knowledge on plants and the recent realization of their economic values thus trading and the act of apprenticing in trading in medicinal plants is now a viable entrepreneurial venture. 54 plant species, belonging to 28 families, have their barks valued for medicine and were sold in the study area. The species were rich in diverse chemical constituents. The sales and patronage of the identified barks, in the study area, transcend gender but skewed to the males due to religious belief thus suggesting that gender specific roles in medicinal plants could be faith-based. Dependence on plant barks was borne out of the age long tradition and confidence of the people on plant medicine. This was complimented by their affordability and ready availability especially in the markets in the study area. Most of the identified barks were sourced outside the study area though forest reserves abound in all parts of the state, yet importation dominated the supply chain as the reserves were highly depleted due to anthropogenic activities. This study tends to support the previous clamour for biodiversity conservation through cultivation of the identified plant species in the study area.
{"title":"Ethnobotanical Survey of Plants’ Stem Barks used in Kaduna State of Nigeria","authors":"M. Ayeni, J. Kayode","doi":"10.18052/WWW.SCIPRESS.COM/IJPPE.12.23","DOIUrl":"https://doi.org/10.18052/WWW.SCIPRESS.COM/IJPPE.12.23","url":null,"abstract":"Inventory of plant species whose barks were sold in markets located in two local government areas of Kaduna State, Nigeria was carried out in this study. Three markets were selected randomly from each of the two Local Government Areas of the study area. In each market, 10 medicinal plant vendors and 10 respondents were randomly selected and interviewed with the aid of semi structure questionnaire matrix. Plants whose stem barks were of medicinal values were identified; their mode of preparations and utilizations were documented. The respondents were diverse and cut across socioeconomic classification. Respondents’ consciousness was linked to oral transfer of the indigenous knowledge on plants and the recent realization of their economic values thus trading and the act of apprenticing in trading in medicinal plants is now a viable entrepreneurial venture. 54 plant species, belonging to 28 families, have their barks valued for medicine and were sold in the study area. The species were rich in diverse chemical constituents. The sales and patronage of the identified barks, in the study area, transcend gender but skewed to the males due to religious belief thus suggesting that gender specific roles in medicinal plants could be faith-based. Dependence on plant barks was borne out of the age long tradition and confidence of the people on plant medicine. This was complimented by their affordability and ready availability especially in the markets in the study area. Most of the identified barks were sourced outside the study area though forest reserves abound in all parts of the state, yet importation dominated the supply chain as the reserves were highly depleted due to anthropogenic activities. This study tends to support the previous clamour for biodiversity conservation through cultivation of the identified plant species in the study area.","PeriodicalId":14237,"journal":{"name":"International Journal of Pharmacology, Phytochemistry and Ethnomedicine","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82817004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-01DOI: 10.18052/WWW.SCIPRESS.COM/IJPPE.11.1
R. Mihăilă
The current treatment of patients with hemophilia A is safer and more effective than the previous one. Prophylactic substitution involves repeated intravenous administration of plasma-derived factor VIII or recombinant factor VIII products, with inconveniences and possible adverse effects. The occurrence of inhibitors requires the administration of activated prothrombin complex concentrate or activated factor VII - an expensive treatment. The immune tolerance induction is the ideal treatment for patients with high titres of inhibitors - the only potential way to eliminate inhibitors and very expensive. For these reasons, the medical world is interested in the advances that scientific research is doing in the field of new molecules without the inconveniences of current substitution therapy and which could replace it in the future. The purpose of this article is to briefly review the new therapeutic possibilities for patients with hemophilia A, which can prevent potential extraarticular bleedings, avoid the occurrence of inhibitors, and have as few adverse effects as possible.
{"title":"A Look at the Future Hemophilia A Treatment","authors":"R. Mihăilă","doi":"10.18052/WWW.SCIPRESS.COM/IJPPE.11.1","DOIUrl":"https://doi.org/10.18052/WWW.SCIPRESS.COM/IJPPE.11.1","url":null,"abstract":"The current treatment of patients with hemophilia A is safer and more effective than the previous one. Prophylactic substitution involves repeated intravenous administration of plasma-derived factor VIII or recombinant factor VIII products, with inconveniences and possible adverse effects. The occurrence of inhibitors requires the administration of activated prothrombin complex concentrate or activated factor VII - an expensive treatment. The immune tolerance induction is the ideal treatment for patients with high titres of inhibitors - the only potential way to eliminate inhibitors and very expensive. For these reasons, the medical world is interested in the advances that scientific research is doing in the field of new molecules without the inconveniences of current substitution therapy and which could replace it in the future. The purpose of this article is to briefly review the new therapeutic possibilities for patients with hemophilia A, which can prevent potential extraarticular bleedings, avoid the occurrence of inhibitors, and have as few adverse effects as possible.","PeriodicalId":14237,"journal":{"name":"International Journal of Pharmacology, Phytochemistry and Ethnomedicine","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81864248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-01DOI: 10.18052/WWW.SCIPRESS.COM/IJPPE.11.7
Augustine N. Okorie, K. Nworie
The leaves of Bauhinia monandra prepared as poultices are used in many Brazilian tribes and some Nigerian communities to relieve swelling and pains, arthritis, diabetes among other ailments. These folkloric claimed benefits inspired this study in which topical and systemic anti-inflammatory activities of a methanol extract of B. monandra leaves (MEBmL) was assessed in rodents. The anti-inflammatory activities of B. monandra were determined by egg albumin-induced (systemic) paw edema in rats, and xylene-induced (topical) ear edema in mice. Treatment of rats with MEBmL at different concentration (200 and 400 mg/kg) led to significant (p<0,05) reduction (31.0% and 28.0% respectively) of the egg albumin-induced paw edema. Topical application of mice ear with MEBmL (50, 100 mg/kg) also significantly (p<0.05) reduced (39.50% and 41.87% respectively) xylene-induced ear edema. Based on the findings of the study, B. monandra has a promising therapeutic potential with its anti-inflammatory activities as associated with folkloric use of the plant.
{"title":"Phytochemical Screening and Anti-Inflammatory Activities of Methanolic Leaf Extract of Bauhinia monandra in Animal Models","authors":"Augustine N. Okorie, K. Nworie","doi":"10.18052/WWW.SCIPRESS.COM/IJPPE.11.7","DOIUrl":"https://doi.org/10.18052/WWW.SCIPRESS.COM/IJPPE.11.7","url":null,"abstract":"The leaves of Bauhinia monandra prepared as poultices are used in many Brazilian tribes and some Nigerian communities to relieve swelling and pains, arthritis, diabetes among other ailments. These folkloric claimed benefits inspired this study in which topical and systemic anti-inflammatory activities of a methanol extract of B. monandra leaves (MEBmL) was assessed in rodents. The anti-inflammatory activities of B. monandra were determined by egg albumin-induced (systemic) paw edema in rats, and xylene-induced (topical) ear edema in mice. Treatment of rats with MEBmL at different concentration (200 and 400 mg/kg) led to significant (p<0,05) reduction (31.0% and 28.0% respectively) of the egg albumin-induced paw edema. Topical application of mice ear with MEBmL (50, 100 mg/kg) also significantly (p<0.05) reduced (39.50% and 41.87% respectively) xylene-induced ear edema. Based on the findings of the study, B. monandra has a promising therapeutic potential with its anti-inflammatory activities as associated with folkloric use of the plant.","PeriodicalId":14237,"journal":{"name":"International Journal of Pharmacology, Phytochemistry and Ethnomedicine","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90285459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-01DOI: 10.18052/WWW.SCIPRESS.COM/IJPPE.11.17
Zegheb Nadjiba, Boubekri Chérifa, T. Lanez, E. Lanez
Molecular docking calculations were used to evaluate the antitumor activities of N-ferrocenylmethyl-N-phenylpropanamide (FP) and N-ferrocenylmethyl-N-pheylbenzohydrazide (FH) against the enzymes of breast cancer 17-beta-hydroxysteroid dehydrogenase type 1 (17β-HSD1) and human steroidogenic cytochrome P450 17A1 prostate cancer mutant A105L (CYP17A1). The molecular docking study was performed using the open source AutoDock 4.2 software. The obtained results showed that both FP and FH bind with 17β-HSD1 and CYP17A1 via hydrogen bonds, binding free energy values for the adducts FH-17β-HSD1 and FH-CYP17A1 were respectively equal to-27.67 and-27.55 KJmol-1, while for the adducts FP-17β-HSD1 and FP-CYP17A1 they were respectively equal to-29.13 and 29.18 KJmol-1. The negative values and the magnitude of the obtained binding free energy indicated respectively the spontaneity and the electrostatic interaction of both ligands FP and FH with 17β-HSD1 and CYP17A1 receptors as the dominant mode. Finally the ligand FP binds more strongly to the receptor CYP17A1 and forms two respective hydrogen bonds with Arg96 and His373; this finding clearly indicate that FP is best qualified as potential drug candidature for breast and prostate cancer.
采用分子对接计算方法评价n -二茂铁甲基- n -苯基丙酰胺(FP)和n -二茂铁甲基- n -苯基苯并肼(FH)对乳腺癌17- β-羟基类固醇脱氢酶1型(17β-HSD1)和人类固醇细胞色素P450 17A1前列腺癌突变体A105L (CYP17A1)的抗肿瘤活性。分子对接研究采用开源AutoDock 4.2软件进行。结果表明，FP和FH通过氢键与17β-HSD1和CYP17A1结合，FH-17β-HSD1和FH-CYP17A1的结合自由能值分别为27.67和27.55 KJmol-1, FP-17β-HSD1和FP-CYP17A1的结合自由能值分别为29.13和29.18 KJmol-1。得到的结合自由能的负值和大小分别表明FP和FH与17β-HSD1和CYP17A1受体的自发性和静电相互作用为主导模式。最后，配体FP与受体CYP17A1结合更强，并分别与Arg96和His373形成两个氢键;这一发现清楚地表明，FP最有资格作为乳腺癌和前列腺癌的潜在候选药物。
{"title":"In Silico Study on N-Ferrocenylmethyl-N-Phenylpropionohydrazide and N-Ferrocenylmethyl-N-Pheylbenzohydrazide as Anticancer Drugs for Breast and Prostate Cancer","authors":"Zegheb Nadjiba, Boubekri Chérifa, T. Lanez, E. Lanez","doi":"10.18052/WWW.SCIPRESS.COM/IJPPE.11.17","DOIUrl":"https://doi.org/10.18052/WWW.SCIPRESS.COM/IJPPE.11.17","url":null,"abstract":"Molecular docking calculations were used to evaluate the antitumor activities of N-ferrocenylmethyl-N-phenylpropanamide (FP) and N-ferrocenylmethyl-N-pheylbenzohydrazide (FH) against the enzymes of breast cancer 17-beta-hydroxysteroid dehydrogenase type 1 (17β-HSD1) and human steroidogenic cytochrome P450 17A1 prostate cancer mutant A105L (CYP17A1). The molecular docking study was performed using the open source AutoDock 4.2 software. The obtained results showed that both FP and FH bind with 17β-HSD1 and CYP17A1 via hydrogen bonds, binding free energy values for the adducts FH-17β-HSD1 and FH-CYP17A1 were respectively equal to-27.67 and-27.55 KJmol-1, while for the adducts FP-17β-HSD1 and FP-CYP17A1 they were respectively equal to-29.13 and 29.18 KJmol-1. The negative values and the magnitude of the obtained binding free energy indicated respectively the spontaneity and the electrostatic interaction of both ligands FP and FH with 17β-HSD1 and CYP17A1 receptors as the dominant mode. Finally the ligand FP binds more strongly to the receptor CYP17A1 and forms two respective hydrogen bonds with Arg96 and His373; this finding clearly indicate that FP is best qualified as potential drug candidature for breast and prostate cancer.","PeriodicalId":14237,"journal":{"name":"International Journal of Pharmacology, Phytochemistry and Ethnomedicine","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75457091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-01DOI: 10.18052/WWW.SCIPRESS.COM/IJPPE.11.26
K. Lenka, N. Pradhan, B. Padhan
Medicinal plants play an important role throughout the world for the treatment and prevention of various diseases of both human and animal. The tribal communities of Koraput still depends on medicinal plants for their first aid remedies to treat some simple ailments of livestock. The present study was initiated to quantitatively document their indigenous knowledge on the utilization of most common medicinal plants for livestock treatment. A total of 40 field surveys were carried out from August 2015 to October 2016 in order to document the utilization of medicinal plants. The ethnoveterinary information was collected through structure interviews among the traditional healers and local livestock farmers . The collected data were analyzed through use value (UV), informant consensus factor (Fic) and fidelity level (FL). A total of 56 species of plants distributed in 54 genera belonging to 36 families were identified as commonly used medicinal plants by the tribal communities of Koraput for the treatment of 20 types of ailments. These ailments were categorized into 9 ailment categories based on the body systems treated. Leaves were the most frequently used plant parts and most of the medicines were prepared in the form of paste and administered orally. Fic values of the present study indicated that there was a high agreement in the use of plants in the treatment of wound infections, dysentery and eye problems among the users. Dermatological infections/diseases and gastro-intestinal disorders had highest use-reports and 2 species of plants had the highest fidelity level of 100%. The most important species according to their use value were Curcuma longa , Ficusreligiosa , Aloe vera, Ziziphusmauritiana, Tridaxprocumbens and Vitexnegundo. As a result of the present study it can be recommend the plants Aloe vera,Azadirachtaindica, Calotropisprocera, Curcuma longa, Daturametel, Ficusreligiosa, Ziziphusmauritiana, Vitexnegundo and Tridaxprocumbens can be investigated further for their ethnopharmacological properties for the discovery of potential new drugs for veterinary treatment.
{"title":"Ethnoveterinary Medicines: A Potential Alternative to Animal Health Care for the Tribal Communities of Koraput, Odisha","authors":"K. Lenka, N. Pradhan, B. Padhan","doi":"10.18052/WWW.SCIPRESS.COM/IJPPE.11.26","DOIUrl":"https://doi.org/10.18052/WWW.SCIPRESS.COM/IJPPE.11.26","url":null,"abstract":"Medicinal plants play an important role throughout the world for the treatment and prevention of various diseases of both human and animal. The tribal communities of Koraput still depends on medicinal plants for their first aid remedies to treat some simple ailments of livestock. The present study was initiated to quantitatively document their indigenous knowledge on the utilization of most common medicinal plants for livestock treatment. A total of 40 field surveys were carried out from August 2015 to October 2016 in order to document the utilization of medicinal plants. The ethnoveterinary information was collected through structure interviews among the traditional healers and local livestock farmers . The collected data were analyzed through use value (UV), informant consensus factor (Fic) and fidelity level (FL). A total of 56 species of plants distributed in 54 genera belonging to 36 families were identified as commonly used medicinal plants by the tribal communities of Koraput for the treatment of 20 types of ailments. These ailments were categorized into 9 ailment categories based on the body systems treated. Leaves were the most frequently used plant parts and most of the medicines were prepared in the form of paste and administered orally. Fic values of the present study indicated that there was a high agreement in the use of plants in the treatment of wound infections, dysentery and eye problems among the users. Dermatological infections/diseases and gastro-intestinal disorders had highest use-reports and 2 species of plants had the highest fidelity level of 100%. The most important species according to their use value were Curcuma longa , Ficusreligiosa , Aloe vera, Ziziphusmauritiana, Tridaxprocumbens and Vitexnegundo. As a result of the present study it can be recommend the plants Aloe vera,Azadirachtaindica, Calotropisprocera, Curcuma longa, Daturametel, Ficusreligiosa, Ziziphusmauritiana, Vitexnegundo and Tridaxprocumbens can be investigated further for their ethnopharmacological properties for the discovery of potential new drugs for veterinary treatment.","PeriodicalId":14237,"journal":{"name":"International Journal of Pharmacology, Phytochemistry and Ethnomedicine","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82493762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.18052/WWW.SCIPRESS.COM/IJPPE.10.36
Carole Nweze Chibuzo, A. Hauwa, A. Zubairu
This study investigated the phytochemical composition andin-vitroradical scavenging activity of ethanolic extracts of Nutraceutical-C24/7 andLandolphialanceolatafruit. Phytochemical screening ofLandolphialanceolatafruit extractindicated the presence of phenols, flavonoids, saponins, alkaloids, terpenoids, tannins, triterpenoids and steroids. While nutraceutical-C24/7 showed precence of with exception of saponins, terpenoids and triterpenoids. Some of the identified Phytochemicals and vitamins concentrations quantified were higher inLandolphialanceolatafruit extractthan nutraceutical-C24/7 with statistically significant difference (p<0.05) with the former having flavonoids 0.062±0.00mg/ml, phenol 0.097±0.00mg/ml, vitamin C 206±42mg/dL, vitamin B154.16±0.00mg/dL and vitamin B20.11±0.00mg/dL while, Nutraceutical-C24/7 extract had flavonoid 0.117±0.00mg/ml, phenol 0.032±0.00, vitamin C 102.24±0.00mg/dL, vitamin B123.36±0.00mg/dL, and vitamin B20.067±0.00mg/dL. The study also showed that at higher concentration, DPPH radical, ferric ion, and hydrogen peroxide the extracts radical scavenging activity increased. The study showed that the extracts scavenging activities at different concentrations had higher percentage inhibition on DPPH radical, reducing power of ferric ion capabilities and reducing composition of hydrogen peroxide indicated that ethanolic extract ofLandolphialanceolatafruits showed statistically significant different (p<0.05) when compared with ethanolic extract of Nutraceutical-C24/7. Standard vitamin C percentage inhibition for DPPH radical compared well with that ofLandolphialanceolatafruit extract at higher concentration with no statistical significant different (p>0.05).The indigenous functional foodLandolphialanceolatafruit can be concluded to be a good antioxidant that can scavenge, inhibit and quench free radicals. This suggests thatLandolphialanceolatamay be considered a good source and alternative antioxidant for developing countries like Nigeria.
{"title":"Comparative Study on Phytochemical Composition and In Vitro Radical Scavenging Activity of Ethanolic Extracts of Landolphia lanceolata and Nutraceutical-C24/7","authors":"Carole Nweze Chibuzo, A. Hauwa, A. Zubairu","doi":"10.18052/WWW.SCIPRESS.COM/IJPPE.10.36","DOIUrl":"https://doi.org/10.18052/WWW.SCIPRESS.COM/IJPPE.10.36","url":null,"abstract":"This study investigated the phytochemical composition andin-vitroradical scavenging activity of ethanolic extracts of Nutraceutical-C24/7 andLandolphialanceolatafruit. Phytochemical screening ofLandolphialanceolatafruit extractindicated the presence of phenols, flavonoids, saponins, alkaloids, terpenoids, tannins, triterpenoids and steroids. While nutraceutical-C24/7 showed precence of with exception of saponins, terpenoids and triterpenoids. Some of the identified Phytochemicals and vitamins concentrations quantified were higher inLandolphialanceolatafruit extractthan nutraceutical-C24/7 with statistically significant difference (p<0.05) with the former having flavonoids 0.062±0.00mg/ml, phenol 0.097±0.00mg/ml, vitamin C 206±42mg/dL, vitamin B154.16±0.00mg/dL and vitamin B20.11±0.00mg/dL while, Nutraceutical-C24/7 extract had flavonoid 0.117±0.00mg/ml, phenol 0.032±0.00, vitamin C 102.24±0.00mg/dL, vitamin B123.36±0.00mg/dL, and vitamin B20.067±0.00mg/dL. The study also showed that at higher concentration, DPPH radical, ferric ion, and hydrogen peroxide the extracts radical scavenging activity increased. The study showed that the extracts scavenging activities at different concentrations had higher percentage inhibition on DPPH radical, reducing power of ferric ion capabilities and reducing composition of hydrogen peroxide indicated that ethanolic extract ofLandolphialanceolatafruits showed statistically significant different (p<0.05) when compared with ethanolic extract of Nutraceutical-C24/7. Standard vitamin C percentage inhibition for DPPH radical compared well with that ofLandolphialanceolatafruit extract at higher concentration with no statistical significant different (p>0.05).The indigenous functional foodLandolphialanceolatafruit can be concluded to be a good antioxidant that can scavenge, inhibit and quench free radicals. This suggests thatLandolphialanceolatamay be considered a good source and alternative antioxidant for developing countries like Nigeria.","PeriodicalId":14237,"journal":{"name":"International Journal of Pharmacology, Phytochemistry and Ethnomedicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82133072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.18052/WWW.SCIPRESS.COM/IJPPE.10.13
Oigbochie Vennessa Eseohe, Osarumwense Marvellous Oghosa, Odiase Daniel Enoghense, O. Kingsley
This study evaluated the effects of administration of aqueous root extracts ofChrysophyllumalbidumon sperm characteristics and histology of the epididymis of experimental rats. Forty-five adult male Wistar rats were randomized into 3 groups of 15 rats each. Each group was further randomized into 3 subgroups of 5 rats each, according to the dose and duration of extract administration. Administration of the extract for 8 weeks resulted in significant (P < 0.05) decreases in the number of progressively motile sperm cells of rats in subgroup B3 (75.00 ± 0.00 %) and C3 (75.00 ± 0.00 %) as compared with the control subgroup A3 (80.00 ± 0.00 %). Also, there were significant (p < 0.05) decreases in the number of morphologically normal sperm cells of rats in test subgroups B3 treated with low dose and C3 treated with high dose. However, there were no significant histological changes in the epididymis of the experimental rats in all the treated groups, at different doses and duration. Administration of aqueous root extract ofChrysophyllumalbidiumat varying doses and time duration negatively affects sperm motility and morphology which may compromise the fertility of the experimental rats.
{"title":"Evaluation of the Effects of Administration of Aqueous Root Extract of Chrysophylum albidum on Fertility in Male Wistar Albino Rats","authors":"Oigbochie Vennessa Eseohe, Osarumwense Marvellous Oghosa, Odiase Daniel Enoghense, O. Kingsley","doi":"10.18052/WWW.SCIPRESS.COM/IJPPE.10.13","DOIUrl":"https://doi.org/10.18052/WWW.SCIPRESS.COM/IJPPE.10.13","url":null,"abstract":"This study evaluated the effects of administration of aqueous root extracts ofChrysophyllumalbidumon sperm characteristics and histology of the epididymis of experimental rats. Forty-five adult male Wistar rats were randomized into 3 groups of 15 rats each. Each group was further randomized into 3 subgroups of 5 rats each, according to the dose and duration of extract administration. Administration of the extract for 8 weeks resulted in significant (P < 0.05) decreases in the number of progressively motile sperm cells of rats in subgroup B3 (75.00 ± 0.00 %) and C3 (75.00 ± 0.00 %) as compared with the control subgroup A3 (80.00 ± 0.00 %). Also, there were significant (p < 0.05) decreases in the number of morphologically normal sperm cells of rats in test subgroups B3 treated with low dose and C3 treated with high dose. However, there were no significant histological changes in the epididymis of the experimental rats in all the treated groups, at different doses and duration. Administration of aqueous root extract ofChrysophyllumalbidiumat varying doses and time duration negatively affects sperm motility and morphology which may compromise the fertility of the experimental rats.","PeriodicalId":14237,"journal":{"name":"International Journal of Pharmacology, Phytochemistry and Ethnomedicine","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86066671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-01DOI: 10.18052/WWW.SCIPRESS.COM/IJPPE.10.1
R. M. Ureta, Siegfred M. Mejico, Yvonne Maranan
Pathological aging due to harmful free radicals and oxidative stress has been a serious threat to human health (Kensella & He, 2008). Thus, the study aimed to evaluate the free radical scavenging activity, antioxidants, essential vitamins, and physicochemical properties of Hydrocotyle vulgaris L. (Pennywort) which could serve as basis in developing a biocosmetic antidote for pathological aging. H.vulgaris L. plant was harvested, air dried and then extracted via soxhlet. UV-vis spectroscopy was used for scavenging activity and antioxidants of the plant while High Performance Liquid Chromatography (HPLC) was applied for the identification of essential vitamins. Phytochemicals, pH and spreadability values of the plant were also tested. Results revealed that H.vulgaris L. has an abundant presence of flavonoid and alkaloid while traced presence of tannin. Good trend for scavenging activity was also observed exhibiting low absorbance of possible free radicals with IC50 of 29.75 and antioxidant activity of 158.13 (Total Phenolics as gallic acid in %w/w). Meanwhile, β-carotene (10.4 mg/kg), Riboflavin (4.08mg/kg), and Vitamins C (70.2mg/kg) and E (26.9mg/kg) were also found in the plant. Non-irritating pH levels of 5.7 and 7.14 for 50% and 75% concentrations of the extracts with good spreadability value of 17.51 g∙cm/sec (for 75% concentration) were also obtained. Based on the findings of the study, Pennywort has a very promising therapeutic characteristics with its good scavenging activity and antioxidants. Thus, the development of a biocosmetic product that could serve as an antidote for pathological aging from Pennywort appeared to be very apparent.
{"title":"Free Radical Scavenging Activity and Antioxidants of Hydrocotyle vulgaris L. (Pennywort): Baseline Study in Developing Biocosmetic-Antidote for Pathological Aging","authors":"R. M. Ureta, Siegfred M. Mejico, Yvonne Maranan","doi":"10.18052/WWW.SCIPRESS.COM/IJPPE.10.1","DOIUrl":"https://doi.org/10.18052/WWW.SCIPRESS.COM/IJPPE.10.1","url":null,"abstract":"Pathological aging due to harmful free radicals and oxidative stress has been a serious threat to human health (Kensella & He, 2008). Thus, the study aimed to evaluate the free radical scavenging activity, antioxidants, essential vitamins, and physicochemical properties of Hydrocotyle vulgaris L. (Pennywort) which could serve as basis in developing a biocosmetic antidote for pathological aging. H.vulgaris L. plant was harvested, air dried and then extracted via soxhlet. UV-vis spectroscopy was used for scavenging activity and antioxidants of the plant while High Performance Liquid Chromatography (HPLC) was applied for the identification of essential vitamins. Phytochemicals, pH and spreadability values of the plant were also tested. Results revealed that H.vulgaris L. has an abundant presence of flavonoid and alkaloid while traced presence of tannin. Good trend for scavenging activity was also observed exhibiting low absorbance of possible free radicals with IC50 of 29.75 and antioxidant activity of 158.13 (Total Phenolics as gallic acid in %w/w). Meanwhile, β-carotene (10.4 mg/kg), Riboflavin (4.08mg/kg), and Vitamins C (70.2mg/kg) and E (26.9mg/kg) were also found in the plant. Non-irritating pH levels of 5.7 and 7.14 for 50% and 75% concentrations of the extracts with good spreadability value of 17.51 g∙cm/sec (for 75% concentration) were also obtained. Based on the findings of the study, Pennywort has a very promising therapeutic characteristics with its good scavenging activity and antioxidants. Thus, the development of a biocosmetic product that could serve as an antidote for pathological aging from Pennywort appeared to be very apparent.","PeriodicalId":14237,"journal":{"name":"International Journal of Pharmacology, Phytochemistry and Ethnomedicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89707849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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