Pub Date : 2011-06-08DOI: 10.1109/IWBP.2011.5954865
A. Giannetti, C. Trono, F. Baldini, L. Bolzoni, G. Porro
A Channel Array Interrogation (CAI) instrument for multiparameter-analysis has been developed. In particular, the portable device was optimized for the C-reactive protein (CRP), one of the analytes of interest for sepsis.
{"title":"The Channel Array Interrogation (CAI) instrument for C-reactive protein analysis","authors":"A. Giannetti, C. Trono, F. Baldini, L. Bolzoni, G. Porro","doi":"10.1109/IWBP.2011.5954865","DOIUrl":"https://doi.org/10.1109/IWBP.2011.5954865","url":null,"abstract":"A Channel Array Interrogation (CAI) instrument for multiparameter-analysis has been developed. In particular, the portable device was optimized for the C-reactive protein (CRP), one of the analytes of interest for sepsis.","PeriodicalId":142421,"journal":{"name":"2011 International Workshop on Biophotonics","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121450693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-06-08DOI: 10.1109/IWBP.2011.5954824
M. Paturzo, A. Finizio, P. Ferraro
We describe a numerical method applied to the reconstruction of a digital hologram, that allows to obtain the image of an object at three planes at different depths simultaneously. In order to do this, we introduce a numerical quadratic deformed diffraction grating into the algorithm.
{"title":"Simultaneous multiplane imaging in digital holographic microscopy","authors":"M. Paturzo, A. Finizio, P. Ferraro","doi":"10.1109/IWBP.2011.5954824","DOIUrl":"https://doi.org/10.1109/IWBP.2011.5954824","url":null,"abstract":"We describe a numerical method applied to the reconstruction of a digital hologram, that allows to obtain the image of an object at three planes at different depths simultaneously. In order to do this, we introduce a numerical quadratic deformed diffraction grating into the algorithm.","PeriodicalId":142421,"journal":{"name":"2011 International Workshop on Biophotonics","volume":"205 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133516897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-06-08DOI: 10.1109/IWBP.2011.5954836
J. Witt, K. Krebber, J. Demuth, L. Šašek
This paper reports on a fiber optic sensor for heart rate measurements. The sensor will be integrated into personal protective equipment within the framework of the FP7 EU project i-Protect. Two different sensor prototypes were developed. One is based on fiber Bragg gratings in silica fiber and the other one is based on macrobending effects in polymer optical fiber.
{"title":"Fiber optic heart rate sensor for integration into personal protective equipment","authors":"J. Witt, K. Krebber, J. Demuth, L. Šašek","doi":"10.1109/IWBP.2011.5954836","DOIUrl":"https://doi.org/10.1109/IWBP.2011.5954836","url":null,"abstract":"This paper reports on a fiber optic sensor for heart rate measurements. The sensor will be integrated into personal protective equipment within the framework of the FP7 EU project i-Protect. Two different sensor prototypes were developed. One is based on fiber Bragg gratings in silica fiber and the other one is based on macrobending effects in polymer optical fiber.","PeriodicalId":142421,"journal":{"name":"2011 International Workshop on Biophotonics","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133799910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-06-08DOI: 10.1109/IWBP.2011.5954815
L. Ascari, M. Giacalone, S. Iannaccone, G. Berrettini, L. Potí
This work presents the latest simulations and experimental results of an innovative module for functional diffused optical imaging based on double nested encoding of wavelength and position of the emitting light. A spread spectrum approach to NIR (near infrared) diffusive optical imaging was recently presented: a pseudo-random bit sequence (PRBS) is used to modulate the light emitted by a continuous emission (CW) laser diode, before entering a turbid medium; when the coded excitation sequence propagates through the tissue, it is split into a group of components that have different path lengths going into the detector. Correlation of the detected signals with the excitation sequence can pick up each component with a specific delay, with the consequence of obtaining time domain (TD) information using cheaper CW sources. We propose to generalize the approach, adopting a two-level code division multiple access (CDMA) technology in an innovative module which is expected to enhance the performances of diffusive imaging systems. We called this technique WS-CDM (wavelength and space code division multiplexing). We describe the module architecture and show the result of numerical simulations; furthermore, experimental activity aimed at validating the approach with two optical signals and related replicas generated by a fading-affected channel is being carried on and preliminary encouraging results will be shown.
{"title":"A spread spectrum approach to diffusive optical spectroscopy and imaging","authors":"L. Ascari, M. Giacalone, S. Iannaccone, G. Berrettini, L. Potí","doi":"10.1109/IWBP.2011.5954815","DOIUrl":"https://doi.org/10.1109/IWBP.2011.5954815","url":null,"abstract":"This work presents the latest simulations and experimental results of an innovative module for functional diffused optical imaging based on double nested encoding of wavelength and position of the emitting light. A spread spectrum approach to NIR (near infrared) diffusive optical imaging was recently presented: a pseudo-random bit sequence (PRBS) is used to modulate the light emitted by a continuous emission (CW) laser diode, before entering a turbid medium; when the coded excitation sequence propagates through the tissue, it is split into a group of components that have different path lengths going into the detector. Correlation of the detected signals with the excitation sequence can pick up each component with a specific delay, with the consequence of obtaining time domain (TD) information using cheaper CW sources. We propose to generalize the approach, adopting a two-level code division multiple access (CDMA) technology in an innovative module which is expected to enhance the performances of diffusive imaging systems. We called this technique WS-CDM (wavelength and space code division multiplexing). We describe the module architecture and show the result of numerical simulations; furthermore, experimental activity aimed at validating the approach with two optical signals and related replicas generated by a fading-affected channel is being carried on and preliminary encouraging results will be shown.","PeriodicalId":142421,"journal":{"name":"2011 International Workshop on Biophotonics","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124646836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-06-08DOI: 10.1109/IWBP.2011.5954848
G. Kanellos, D. Tsiokos, N. Pleros, P. Childs, S. Pissadakis
We present pressure FBG-based sensor pads that exhibit enhanced durability and are suitable for application in human-machine interface surfaces for rehabilitation and biomechanics applications, such as medical beds, wheelchairs and amputee sockets.
{"title":"Enhanced durability FBG-based sensor pads for biomedical applications as human-machine interface surfaces","authors":"G. Kanellos, D. Tsiokos, N. Pleros, P. Childs, S. Pissadakis","doi":"10.1109/IWBP.2011.5954848","DOIUrl":"https://doi.org/10.1109/IWBP.2011.5954848","url":null,"abstract":"We present pressure FBG-based sensor pads that exhibit enhanced durability and are suitable for application in human-machine interface surfaces for rehabilitation and biomechanics applications, such as medical beds, wheelchairs and amputee sockets.","PeriodicalId":142421,"journal":{"name":"2011 International Workshop on Biophotonics","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132440422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-06-08DOI: 10.1109/IWBP.2011.5954861
L. Ferrara, F. Bragheri, P. Minzioni, I. Cristiani, K. Vishnubhatla, N. Bellini, R. Ramponi, R. Osellame
We present an optofluidic monolithic chip for the study of mechanical properties of single cells by means of optical forces. The chip is fabricated by femtosecond laser micromachining in a fused silica glass substrate
{"title":"Single cell trapping and stretching in a femtosecond laser fabricated optofluidic chip","authors":"L. Ferrara, F. Bragheri, P. Minzioni, I. Cristiani, K. Vishnubhatla, N. Bellini, R. Ramponi, R. Osellame","doi":"10.1109/IWBP.2011.5954861","DOIUrl":"https://doi.org/10.1109/IWBP.2011.5954861","url":null,"abstract":"We present an optofluidic monolithic chip for the study of mechanical properties of single cells by means of optical forces. The chip is fabricated by femtosecond laser micromachining in a fused silica glass substrate","PeriodicalId":142421,"journal":{"name":"2011 International Workshop on Biophotonics","volume":"220 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132405184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-06-08DOI: 10.1109/IWBP.2011.5954822
A. Sonato, G. Ruffato, M. Natali, G. Zacco, M. Morpurgo, D. Silvestri, M. Dettin, F. Romanato
We designed and experimentally realized the prototype for a bio-recognition device based on Grating Coupled Surface Plasmon Resonance (GCSPR) which can find a wide range of applications for detection of chemical and biological species. A sinusoidal grating (period of 500 nm and peak-to-valley height of 40 nm) was realized by Laser Interference Lithography (LIL) and replicated onto a polymeric resin film. After substrate coating with a Cr/Au film a thio-mPEO (Mw 5000) layer with a medium thickness of 4 nm was deposited onto the plasmonic surface. The SPR detection system allowed to detect the biological layer with a refractive index sensitivity of 995.2°/RIU. Our solution has been demonstrated to be a very sensitive platform for the development of a complete GCSPR biosensor.
{"title":"Plasmonic Platforms for Biodetection Devices","authors":"A. Sonato, G. Ruffato, M. Natali, G. Zacco, M. Morpurgo, D. Silvestri, M. Dettin, F. Romanato","doi":"10.1109/IWBP.2011.5954822","DOIUrl":"https://doi.org/10.1109/IWBP.2011.5954822","url":null,"abstract":"We designed and experimentally realized the prototype for a bio-recognition device based on Grating Coupled Surface Plasmon Resonance (GCSPR) which can find a wide range of applications for detection of chemical and biological species. A sinusoidal grating (period of 500 nm and peak-to-valley height of 40 nm) was realized by Laser Interference Lithography (LIL) and replicated onto a polymeric resin film. After substrate coating with a Cr/Au film a thio-mPEO (Mw 5000) layer with a medium thickness of 4 nm was deposited onto the plasmonic surface. The SPR detection system allowed to detect the biological layer with a refractive index sensitivity of 995.2°/RIU. Our solution has been demonstrated to be a very sensitive platform for the development of a complete GCSPR biosensor.","PeriodicalId":142421,"journal":{"name":"2011 International Workshop on Biophotonics","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125641753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-06-08DOI: 10.1109/IWBP.2011.5954854
Lorenzo Rosa, R. Buividas, S. Juodkazis, T. Kondo, H. Masuda
We propose a novel substrate for SERS bio-sensing composed of an hexagonal array of gold nanorods embedded in an anodically-oxidized alumina substrate, reaching a surface field enhancement up to 220 times.
{"title":"Alumina-embedded Au nanowires for SERS sensing","authors":"Lorenzo Rosa, R. Buividas, S. Juodkazis, T. Kondo, H. Masuda","doi":"10.1109/IWBP.2011.5954854","DOIUrl":"https://doi.org/10.1109/IWBP.2011.5954854","url":null,"abstract":"We propose a novel substrate for SERS bio-sensing composed of an hexagonal array of gold nanorods embedded in an anodically-oxidized alumina substrate, reaching a surface field enhancement up to 220 times.","PeriodicalId":142421,"journal":{"name":"2011 International Workshop on Biophotonics","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128874590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-06-01DOI: 10.1109/IWBP.2011.5954798
Michele Benetti, Marina Popleteeva, G. Betta, L. Pancheri, C. Collini, E. Morganti, L. Lorenzelli, L. Lunelli, L. Pasquardini, C. Pederzolli, D. Stoppa
Fluorescence lifetime measurement is used in biological research to enhance the contrast of fluorescence images. The outstanding sensitivity that can be achieved with this method is obtained at the expense of a high data throughput. A substantial data reduction can be achieved using the time-gated technique, which consists in counting the number of photons occurring inside different time windows. Thanks to the recent developments in the realization of Single Photon Avalanche Diodes (SPAD) in standard CMOS technologies, this technique can be monolithically implemented on-chip. In this work, three different detectors fabricated within a 0.35 ▪m High Voltage CMOS technology will be described, focusing onto their use in lifetime imaging. The sensors have been designed for different optical setups and for different applications, ranging from Fluorescence Lifetime Imaging Microscopy to miniaturized Lab-on-Chip. The advantages and limitation of the proposed sensors will be pointed out and a case study of a specific application will be presented.
{"title":"CMOS single-photon detector for advanced fluorescence sensing applications","authors":"Michele Benetti, Marina Popleteeva, G. Betta, L. Pancheri, C. Collini, E. Morganti, L. Lorenzelli, L. Lunelli, L. Pasquardini, C. Pederzolli, D. Stoppa","doi":"10.1109/IWBP.2011.5954798","DOIUrl":"https://doi.org/10.1109/IWBP.2011.5954798","url":null,"abstract":"Fluorescence lifetime measurement is used in biological research to enhance the contrast of fluorescence images. The outstanding sensitivity that can be achieved with this method is obtained at the expense of a high data throughput. A substantial data reduction can be achieved using the time-gated technique, which consists in counting the number of photons occurring inside different time windows. Thanks to the recent developments in the realization of Single Photon Avalanche Diodes (SPAD) in standard CMOS technologies, this technique can be monolithically implemented on-chip. In this work, three different detectors fabricated within a 0.35 ▪m High Voltage CMOS technology will be described, focusing onto their use in lifetime imaging. The sensors have been designed for different optical setups and for different applications, ranging from Fluorescence Lifetime Imaging Microscopy to miniaturized Lab-on-Chip. The advantages and limitation of the proposed sensors will be pointed out and a case study of a specific application will be presented.","PeriodicalId":142421,"journal":{"name":"2011 International Workshop on Biophotonics","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132643069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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