A simple, quick, precise and accurate HPLC (reverse phase) approach has been designed and optimized using a chemometric tool to estimate dolutegravir, emtricitabine and tenofovir alafenamide, respectively. A design of central composite was used to optimize the response surface. As a result of trial and error, the parameters such as rate of solvent flow, buffer pH, and methanol concentration in the solvent system were determined. System responsiveness was estimated using the optimization process’s capacity factor, resolution, and retention time. The separation was achieved by using a solvent system containing 58.90% methanol and 41.10 triethylamine buffer (4.56 pH) at the rate of flow of 0.8 mL per minute on a phenomenex carbon (18) column (150.4 4.6 mm; I.D., 5) under optimal conditions. The duration of retention for emtricitabine was 2.91 minutes, for tenofovir alafenamide it was 6.114 minutes; and for dolutegravir it was 8.824 minutes. A correlation coefficient of 0.9998, 0.9997, and 0.9999 was determined for emtricitabine’s calibration curves from 40 to 200 g/mL, tenofovir alafenamide’s from 5 to 25 g/mL, and emtricitabine’s from 10 to 50 g/mL, respectively. This approach was effective in estimating the simultaneous doses of medications in commercial combination forms
{"title":"Development, Optimization, and Validation of a RP-HPLC Method with PDA Detection for the Concurrent Quantification of Emtricitabine, Tenofovir Alafenamide, and Dolutegravir in Both Bulk and Pharmaceutical Dosage Forms","authors":"Chandrudu J, Gandhimathi R","doi":"10.25258/ijpqa.14.3.05","DOIUrl":"https://doi.org/10.25258/ijpqa.14.3.05","url":null,"abstract":"A simple, quick, precise and accurate HPLC (reverse phase) approach has been designed and optimized using a chemometric tool to estimate dolutegravir, emtricitabine and tenofovir alafenamide, respectively. A design of central composite was used to optimize the response surface. As a result of trial and error, the parameters such as rate of solvent flow, buffer pH, and methanol concentration in the solvent system were determined. System responsiveness was estimated using the optimization process’s capacity factor, resolution, and retention time. The separation was achieved by using a solvent system containing 58.90% methanol and 41.10 triethylamine buffer (4.56 pH) at the rate of flow of 0.8 mL per minute on a phenomenex carbon (18) column (150.4 4.6 mm; I.D., 5) under optimal conditions. The duration of retention for emtricitabine was 2.91 minutes, for tenofovir alafenamide it was 6.114 minutes; and for dolutegravir it was 8.824 minutes. A correlation coefficient of 0.9998, 0.9997, and 0.9999 was determined for emtricitabine’s calibration curves from 40 to 200 g/mL, tenofovir alafenamide’s from 5 to 25 g/mL, and emtricitabine’s from 10 to 50 g/mL, respectively. This approach was effective in estimating the simultaneous doses of medications in commercial combination forms","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The most frequent reason patients seek medical assistance is because of a persistent cough, despite the fact that coughing is both a crucial defensive reflex and a universal indication of health. According to an epidemiologic study, up to 40% of people report coughing. Upper respiratory tract infections (URTIs) and the common cold are the most frequent causes of cough, but other causes include post-infectious cough, undiagnosed chronic cough, and cough brought on by pulmonary diseases like asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, and lung cancer. The most common causes of cough in children are viral URTI, chronic bacterial bronchitis, and asthma. Whether acute or chronic, cough is linked to considerably reducing health-related quality of life. Patients with chronic cough commonly report sleep disturbance, nausea, chest pains, lethargy, social humiliation, urine incontinence, and low mood. Coughing may not be effective in certain circumstances (such as respiratory tract inflammation, neoplasia, eosinophilic bronchitis, airway irritation from various pollutants, airway hyperresponsiveness from infection, gastroesophageal reflux disease, and coughing without any known cause, also known as idiopathic cough). Opioidergic central cough suppressants, such as opioids, codeine, pholcodine, noscapine, and dextromethorphan, are useful when coughing is ineffective. Constipation, sedation, respiratory depression, dependence, drowsiness, addiction, and even mortality can result from prolonged use of these cough suppressants, which restricts their use in people. The proposed research project’s objective is to develop and assess herbal dosage forms that contain the widely used spice Piper longum L. (Piperaceae).
{"title":"Formulation and Evaluation of Herbal Remedy for Cough","authors":"Anjali Bedse, Ashwini Nalawade, Suchita Dhamane, Ramanlal Kachave, Vijay Wagh, Harshal Tare, Gauri Ghangale","doi":"10.25258/ijpqa.14.3.51","DOIUrl":"https://doi.org/10.25258/ijpqa.14.3.51","url":null,"abstract":"The most frequent reason patients seek medical assistance is because of a persistent cough, despite the fact that coughing is both a crucial defensive reflex and a universal indication of health. According to an epidemiologic study, up to 40% of people report coughing. Upper respiratory tract infections (URTIs) and the common cold are the most frequent causes of cough, but other causes include post-infectious cough, undiagnosed chronic cough, and cough brought on by pulmonary diseases like asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, and lung cancer. The most common causes of cough in children are viral URTI, chronic bacterial bronchitis, and asthma. Whether acute or chronic, cough is linked to considerably reducing health-related quality of life. Patients with chronic cough commonly report sleep disturbance, nausea, chest pains, lethargy, social humiliation, urine incontinence, and low mood. Coughing may not be effective in certain circumstances (such as respiratory tract inflammation, neoplasia, eosinophilic bronchitis, airway irritation from various pollutants, airway hyperresponsiveness from infection, gastroesophageal reflux disease, and coughing without any known cause, also known as idiopathic cough). Opioidergic central cough suppressants, such as opioids, codeine, pholcodine, noscapine, and dextromethorphan, are useful when coughing is ineffective. Constipation, sedation, respiratory depression, dependence, drowsiness, addiction, and even mortality can result from prolonged use of these cough suppressants, which restricts their use in people. The proposed research project’s objective is to develop and assess herbal dosage forms that contain the widely used spice Piper longum L. (Piperaceae).","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present paper is based on the combination of MAOI hydrazide moiety and tricyclic antidepressant moiety. This combination investigates new compounds as 1,3,4-oxadiazinoindole derivatives to find potent and safer antidepressants. Synthesis of 1,3,4-oxadiazinoindole derivatives are started from various animoacids. The sequence of synthesis reactions such as benzoylation reaction, Halo-De-hydroxylation (Nucleophilic substitution reaction), Schotten-Baumann reaction, Nucleophilic addition and finally cyclization reaction (Cyclo-De-Hydroxylation) are involved. Synthesized compounds are characterized via melting point, TLC, FT infrared spectroscopy, 1H-NMR, and mass spectroscopy techniques. All compound’s structures are confirmed.
本论文是基于MAOI肼段和三环抗抑郁药段的组合。该组合研究了1,3,4-恶二嗪吲哚衍生物的新化合物，以发现有效且更安全的抗抑郁药。以各种氨基酸为原料合成1,3,4-恶二嗪吲哚衍生物。合成反应的顺序为苯甲酰化反应、halo - de -羟基化反应(亲核取代反应)、Schotten-Baumann反应、亲核加成反应，最后是环化反应(环- de -羟基化反应)。合成的化合物通过熔点、TLC、FT红外光谱、1H-NMR和质谱技术进行表征。所有化合物的结构都得到了确认。
{"title":"To Synthesis and Characterization of Novel 1,3,4-Oxadiazinoindole Derivatives for the Purpose of Antidepressant Activity","authors":"Mahadev Agarwal, Neelam Singla, S.K Singh","doi":"10.25258/ijpqa.14.3.33","DOIUrl":"https://doi.org/10.25258/ijpqa.14.3.33","url":null,"abstract":"The present paper is based on the combination of MAOI hydrazide moiety and tricyclic antidepressant moiety. This combination investigates new compounds as 1,3,4-oxadiazinoindole derivatives to find potent and safer antidepressants. Synthesis of 1,3,4-oxadiazinoindole derivatives are started from various animoacids. The sequence of synthesis reactions such as benzoylation reaction, Halo-De-hydroxylation (Nucleophilic substitution reaction), Schotten-Baumann reaction, Nucleophilic addition and finally cyclization reaction (Cyclo-De-Hydroxylation) are involved. Synthesized compounds are characterized via melting point, TLC, FT infrared spectroscopy, 1H-NMR, and mass spectroscopy techniques. All compound’s structures are confirmed.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dharmesh Trivedi, Seema Joshi, Amit Jain, Sagar S Jadkar, Rahul I Jadhav, Gajendra S Rathore, Anshu Sharma
It is feasible to extract nanocellulose, in particular alpha nanocellulose, from agricultural waste products such as cow dung. This is the case. Nanocellulose of this particular form exhibits unique properties, making it an excellent candidate for biological applications. This review aims to discuss the biomedical applications of cow dung-derived alpha nanocellulose. Nanocellulose has a larger surface area, greater mechanical strength, and better biocompatibility than other cellulose nanomaterials. It starts off by walking through the process of removing nanocellulose from cow manure. Alpha nanocellulose has applications in tissue engineering, the administration of medicines, the healing of wounds, as well as biosensing. Each application is broken down into its component parts, providing insights into the underlying mechanisms, experimental investigations, as well as in-vitro and in-vivo evaluations to establish the viability and effectiveness of alpha nanocellulose. The review paper also discusses the difficulties encountered and the potential future applications of alpha nanocellulose derived from cow dung in biomedicine. These difficulties include the requirement for standardized extraction processes, the optimization of material properties, and the consideration of regulatory issues. This in-depth study demonstrates that alpha nanocellulose that is generated from cow dung is a versatile and environmentally friendly nanomaterial that can be used for medical applications. It is hoped that the findings of this study will inspire more research and creative applications based on the unique properties of alpha nanocellulose, possibly resulting in biomedical breakthroughs by consolidating knowledge and exploring new areas.
{"title":"Potential Applications of Alpha Nanocellulose from Cow Dung in Biomedicine: A Comprehensive Review","authors":"Dharmesh Trivedi, Seema Joshi, Amit Jain, Sagar S Jadkar, Rahul I Jadhav, Gajendra S Rathore, Anshu Sharma","doi":"10.25258/ijpqa.14.3.57","DOIUrl":"https://doi.org/10.25258/ijpqa.14.3.57","url":null,"abstract":"It is feasible to extract nanocellulose, in particular alpha nanocellulose, from agricultural waste products such as cow dung. This is the case. Nanocellulose of this particular form exhibits unique properties, making it an excellent candidate for biological applications. This review aims to discuss the biomedical applications of cow dung-derived alpha nanocellulose. Nanocellulose has a larger surface area, greater mechanical strength, and better biocompatibility than other cellulose nanomaterials. It starts off by walking through the process of removing nanocellulose from cow manure. Alpha nanocellulose has applications in tissue engineering, the administration of medicines, the healing of wounds, as well as biosensing. Each application is broken down into its component parts, providing insights into the underlying mechanisms, experimental investigations, as well as in-vitro and in-vivo evaluations to establish the viability and effectiveness of alpha nanocellulose. The review paper also discusses the difficulties encountered and the potential future applications of alpha nanocellulose derived from cow dung in biomedicine. These difficulties include the requirement for standardized extraction processes, the optimization of material properties, and the consideration of regulatory issues. This in-depth study demonstrates that alpha nanocellulose that is generated from cow dung is a versatile and environmentally friendly nanomaterial that can be used for medical applications. It is hoped that the findings of this study will inspire more research and creative applications based on the unique properties of alpha nanocellulose, possibly resulting in biomedical breakthroughs by consolidating knowledge and exploring new areas.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral drug administration is essential for treating diverse diseases due to its acceptable route, non-invasiveness, minimal off-target side effects, versatility, and painless patient delivery. However, multiple drug accessibility is increasing currently but there is often a deficiency of indication in developing procedures with assessment of two diverse medicinal formulations. Oral administration of a novel antiepileptic drug, levetiracetam in grouping with either L-dopa unaccompanied or L-dopa/Ropinirole treatments was associated with dyskinesia. Altered shooting patterns of neurons relating to a compulsive harmonization process may back to the origin of dyskinesia. The current study aims to develop a dissolution technique and validate the antiparkinsonian drug-ropinirole and antiepileptic drug-levetiracetam tablets by RP-HPLC, which plays a major part in pharmaceutical formulations. The optimal dissolution conditions were experienced for the products respective to the pharmaceutical formulation and applied to assess the dissolution profiles. Ideal settings for the dissolution method were 500 mL of pH of 4.0 citrate buffer, 50 rpm and 250 nm for ropinirole tablets and 900 mL of distilled water, the rotation speed of paddle 50 rpm and 217 nm for levetiracetam tablets, then 3.84 and 3.87 minutes were set as the retention time of ropinirole and levetiracetam tablets, respectively. Technique optimization and validation process helps to reduce the bioequivalence of both dosage forms. The current study ensues detailed information on the drug release, even if there is a change in pH medium, filter, rpm, instrumentation, etc. Focusing on current pharmaceutical sciences, the proposed correlative dissolution study coupled with RP-HPLC analysis could offer a holistic insight into the performance of future oral drug delivery systems
{"title":"A Correlative Dissolution Study of Oral Drug Delivery Systems through Reverse Phase-HPLC Analysis","authors":"S Poongothai, R Srinivasan, M Rama","doi":"10.25258/ijpqa.14.3.15","DOIUrl":"https://doi.org/10.25258/ijpqa.14.3.15","url":null,"abstract":"Oral drug administration is essential for treating diverse diseases due to its acceptable route, non-invasiveness, minimal off-target side effects, versatility, and painless patient delivery. However, multiple drug accessibility is increasing currently but there is often a deficiency of indication in developing procedures with assessment of two diverse medicinal formulations. Oral administration of a novel antiepileptic drug, levetiracetam in grouping with either L-dopa unaccompanied or L-dopa/Ropinirole treatments was associated with dyskinesia. Altered shooting patterns of neurons relating to a compulsive harmonization process may back to the origin of dyskinesia. The current study aims to develop a dissolution technique and validate the antiparkinsonian drug-ropinirole and antiepileptic drug-levetiracetam tablets by RP-HPLC, which plays a major part in pharmaceutical formulations. The optimal dissolution conditions were experienced for the products respective to the pharmaceutical formulation and applied to assess the dissolution profiles. Ideal settings for the dissolution method were 500 mL of pH of 4.0 citrate buffer, 50 rpm and 250 nm for ropinirole tablets and 900 mL of distilled water, the rotation speed of paddle 50 rpm and 217 nm for levetiracetam tablets, then 3.84 and 3.87 minutes were set as the retention time of ropinirole and levetiracetam tablets, respectively. Technique optimization and validation process helps to reduce the bioequivalence of both dosage forms. The current study ensues detailed information on the drug release, even if there is a change in pH medium, filter, rpm, instrumentation, etc. Focusing on current pharmaceutical sciences, the proposed correlative dissolution study coupled with RP-HPLC analysis could offer a holistic insight into the performance of future oral drug delivery systems","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Two pharmaceutical compounds were isolated, separated, and confirmed using chromatographic techniques. The method involved utilizing an inertsil phenyl analytical the analytical column has dimensions of 250 mm x 4.0 mm and contains particles with a size of 5 μm. A solution is filled as a buffer, combined with a mobile phase containing a grid. with a pH of 4.0 made from potassium dihydrogen phosphate, orthophosphoric acid and of acetonitrile in a 70:30 ratio 0.8 mL per minute. The column temperature is maintained at 30℃ as part of the setup. The detection of the two drugs is continuously monitored using this setup. A wavelength of 210 nm using a UV detector with injection volume 20 μL. Forced degradation studies are carried out using PDA detector. Peak homogeneity explained as peak purity using lab solution software
用色谱技术分离、分离和确认了两种药物化合物。该方法使用惯性苯基分析柱，分析柱尺寸为250 mm x 4.0 mm，包含尺寸为5 μm的颗粒。溶液被填充为缓冲器，与包含网格的移动相结合。pH为4.0，由磷酸二氢钾、正磷酸和乙腈按70:30的比例配制，每分钟0.8 mL。作为设置的一部分，色谱柱温度保持在30℃。使用该装置连续监测两种药物的检测。波长为210 nm，进样量为20 μL。使用PDA检测器进行强制降解研究。使用实验室溶液软件将峰均匀性解释为峰纯度
{"title":"Stability Indicating Assay Method Development and Validation of Sitagliptin and Metformin Combination Tablets by Reverse Phase - HPLC","authors":"Gogada V.P Rao, Meka Lingam, Bavisetti Lakshmi, Anantha L Vadivelu, Duvvuri Suryakala","doi":"10.25258/ijpqa.14.3.19","DOIUrl":"https://doi.org/10.25258/ijpqa.14.3.19","url":null,"abstract":"Two pharmaceutical compounds were isolated, separated, and confirmed using chromatographic techniques. The method involved utilizing an inertsil phenyl analytical the analytical column has dimensions of 250 mm x 4.0 mm and contains particles with a size of 5 μm. A solution is filled as a buffer, combined with a mobile phase containing a grid. with a pH of 4.0 made from potassium dihydrogen phosphate, orthophosphoric acid and of acetonitrile in a 70:30 ratio 0.8 mL per minute. The column temperature is maintained at 30℃ as part of the setup. The detection of the two drugs is continuously monitored using this setup. A wavelength of 210 nm using a UV detector with injection volume 20 μL. Forced degradation studies are carried out using PDA detector. Peak homogeneity explained as peak purity using lab solution software","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A novel idea in medicine delivery is the use of nanosponges. In the current research, an effort was made to create in-situ gel based on nanosponges that contained abiraterone acetate loaded with quercetin. The major purpose of nanosponges is to offer a prolonged release, lessen the negative effects of conventional dosage forms, and enhance the bioavailability of abiraterone acetate by using quercetin as a natural bioenhancer. Combining ethyl cellulose and eudragit in varying quantities, the quasi emulsion solvent diffusion technique was used to create nanosponges and quercetin as a natural bioenhancer. The formulation properties of the produced nanosponges were assessed. All batches of nanosponges had their manufacturing yield and trapping effectiveness assessed. Formulations F 03-P1 and F 07-P2 were found to be the optimum formulations based on results. Both F 03- P1 and F 07-P2 were used to create the gels G1 and G2. Viscosity, spreadability, drug content, and in-vitro tests showing 28.88% drug release after 24 hours all favored G2 as the optimal formulation. A gel base was created using the optimized formulation after it had been tested for scanning electron microscopy (SEM) analysis. Nanosponges containing gel had evaluated for different tests. According to the study, adding drugs to nanosponges can increase the rate of drug release, improve medication targeting at a particular spot, and hence lessen systemic toxicity.
{"title":"Formulation And Evaluation of Quercetin Loaded Nanosponges of Abiraterone Acetate","authors":"Suvarna Thorat, Manoj Tare","doi":"10.25258/ijpqa.14.3.32","DOIUrl":"https://doi.org/10.25258/ijpqa.14.3.32","url":null,"abstract":"A novel idea in medicine delivery is the use of nanosponges. In the current research, an effort was made to create in-situ gel based on nanosponges that contained abiraterone acetate loaded with quercetin. The major purpose of nanosponges is to offer a prolonged release, lessen the negative effects of conventional dosage forms, and enhance the bioavailability of abiraterone acetate by using quercetin as a natural bioenhancer. Combining ethyl cellulose and eudragit in varying quantities, the quasi emulsion solvent diffusion technique was used to create nanosponges and quercetin as a natural bioenhancer. The formulation properties of the produced nanosponges were assessed. All batches of nanosponges had their manufacturing yield and trapping effectiveness assessed. Formulations F 03-P1 and F 07-P2 were found to be the optimum formulations based on results. Both F 03- P1 and F 07-P2 were used to create the gels G1 and G2. Viscosity, spreadability, drug content, and in-vitro tests showing 28.88% drug release after 24 hours all favored G2 as the optimal formulation. A gel base was created using the optimized formulation after it had been tested for scanning electron microscopy (SEM) analysis. Nanosponges containing gel had evaluated for different tests. According to the study, adding drugs to nanosponges can increase the rate of drug release, improve medication targeting at a particular spot, and hence lessen systemic toxicity.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fungal infections continue to endanger human health, and the problem is only becoming worse. Combination therapy may be an optional strategy for the treatment of invasive fungal illnesses, and the potential antifungal mechanisms provide new insights into the development of innovative antifungal medications. Numerous investigations have shown that combining plant extract showed significant antifungal activity. In the present work, a topical fungal formulation containing hydroalcoholic extract of Leonotis nepetaefolia (L) R.Br. (TFF) in form of a cream was estimated for apigenin. A technique has been created and validated using UV spectrophotometric analysis in order to evaluate the aforementioned drugs simultaneously in the formulation
{"title":"UV Spectrophotometric Analysis of Apigenin in Topical Fungal Formulation containing Extract of Leonotis nepetaefolia (L) R. Br.","authors":"Sumeet Dwivedi, Supriya Shidhaye, Abhishek Dwivedi, Sumit Prachad, Ishika Mishra, Amit Gangwal, Abhishek Kumar","doi":"10.25258/ijpqa.14.3.17","DOIUrl":"https://doi.org/10.25258/ijpqa.14.3.17","url":null,"abstract":"Fungal infections continue to endanger human health, and the problem is only becoming worse. Combination therapy may be an optional strategy for the treatment of invasive fungal illnesses, and the potential antifungal mechanisms provide new insights into the development of innovative antifungal medications. Numerous investigations have shown that combining plant extract showed significant antifungal activity. In the present work, a topical fungal formulation containing hydroalcoholic extract of Leonotis nepetaefolia (L) R.Br. (TFF) in form of a cream was estimated for apigenin. A technique has been created and validated using UV spectrophotometric analysis in order to evaluate the aforementioned drugs simultaneously in the formulation","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hyperglycemia caused by defects in insulin synthesis and/or activity characterizes diabetes mellitus (DM), which is categorized as a metabolic condition. Some patients may develop side effects or drug interactions when treating these disorders with synthetic drugs. Due to this, there is an increased interest in researching the medical properties of plants and herbal substances while also considering synthetic medications’ interactions and negative effects. To isolate and identify the flavonoid 5-hydroxy-apigenin-7-O-Dglucopyranoside, the bark of Olax scandens was extracted with methanol in a soxhlet system (5HAG). The current study set out to examine 5HAG’s potential ability to treat albino wistar rats with STZ-induced diabetes. The chemical component significantly lowered rats’ blood glucose levels and improved lipid markers. Hepatic enzymes improved significantly, including SGOT, SGPT, ALP, plasma insulin, and total proteins. Overall, this study exposes new avenues for researching how 5HAG reduces blood sugar levels so drastically, but according to the aforementioned study, the flavonoid possesses antidiabetic properties because of its antioxidant activity. In addition, the isolated flavonoid may significantly impact the reduction of blood sugar and its complications by acting as a lead molecule in the identification of novel antidiabetic drug candidates.
由胰岛素合成和/或活性缺陷引起的高血糖是糖尿病(DM)的特征，它被归类为一种代谢疾病。当使用合成药物治疗这些疾病时，一些患者可能会出现副作用或药物相互作用。正因为如此，人们对研究植物和草药物质的医学特性越来越感兴趣，同时也考虑到合成药物的相互作用和负面影响。为了分离和鉴定黄酮类化合物5-羟基芹菜素-7- o -二葡萄糖吡喃苷，在索氏体系(5HAG)中对山茱萸树皮进行甲醇萃取。目前的研究旨在检测5HAG治疗stz诱导的白化wistar大鼠糖尿病的潜在能力。这种化学成分显著降低了大鼠的血糖水平，改善了血脂指标。肝酶显著改善，包括SGOT、SGPT、ALP、血浆胰岛素和总蛋白。总的来说，这项研究为研究5HAG如何如此急剧地降低血糖水平提供了新的途径，但根据上述研究，类黄酮具有抗氧化活性，因此具有抗糖尿病特性。此外，分离得到的黄酮类化合物可能作为先导分子在鉴定新的抗糖尿病候选药物中具有显著的降低血糖及其并发症的作用。
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Ahmed M. Asiri, Salman A. Alzahrani, Afrah Y. Saddeek, Faisal A. Ghazwani, Abdulhakeem Alotaibi, Shahalil Alqani
A cardiac arrest patient who has recovered outside the hospital, managing body temperature is beneficial. There is still uncertainty as to what specific circumstances should be met in order for such interventions to be initiated. Researchers have used different methods to study OHCA TTM interventions due to the uncertainty surrounding their outcomes. The study’s main objective is to determine if temperature management affects survival outcomes in adult cardiac arrests occurring outside of the hospital. Several online databases were examined to collect data, including Web of Science, PubMed Central, Medline, Embase and Cochrane. Our study examined several randomized controlled trials, including randomized clinical trials and randomized controlled trials that involved TTM interventions in adult OHCA patients. An analysis was conducted based on the search criteria for screening, collecting, and extracting data. Based primarily on qualitative analysis, a synthesis was conducted. There were 21 studies with a total of 11435 participants, with a median sample of 355, and none of them demonstrated sufficient qualitative and quantitative evidence indicating that TTM interventional variants were safe, feasible, efficient, and effective on neurological and mortality outcomes in OHCA patients.
心脏骤停的病人在医院外康复，控制体温是有益的。要开始进行这种干预，需要满足哪些具体情况，目前仍不确定。由于其结果的不确定性，研究人员使用了不同的方法来研究OHCA TTM干预措施。该研究的主要目的是确定体温管理是否会影响在医院外发生的成人心脏骤停的生存结果。研究人员检查了几个在线数据库来收集数据，包括Web of Science、PubMed Central、Medline、Embase和Cochrane。我们的研究检查了几个随机对照试验，包括随机临床试验和随机对照试验，涉及TTM干预成年OHCA患者。根据筛选、收集和提取数据的搜索标准进行分析。在定性分析的基础上，进行了综合。共有21项研究，共11435名参与者，中位样本为355人，没有一项研究提供足够的定性和定量证据，表明TTM介入变异对OHCA患者的神经和死亡率结局是安全、可行、有效和有效的。
{"title":"Assessing the Impact of Temperature Management Interventions on Survival Outcomes in Adult Out-of-Hospital Cardiac Arrest: A Comprehensive Review of Randomized Controlled Trials","authors":"Ahmed M. Asiri, Salman A. Alzahrani, Afrah Y. Saddeek, Faisal A. Ghazwani, Abdulhakeem Alotaibi, Shahalil Alqani","doi":"10.25258/ijpqa.14.3.09","DOIUrl":"https://doi.org/10.25258/ijpqa.14.3.09","url":null,"abstract":"A cardiac arrest patient who has recovered outside the hospital, managing body temperature is beneficial. There is still uncertainty as to what specific circumstances should be met in order for such interventions to be initiated. Researchers have used different methods to study OHCA TTM interventions due to the uncertainty surrounding their outcomes. The study’s main objective is to determine if temperature management affects survival outcomes in adult cardiac arrests occurring outside of the hospital. Several online databases were examined to collect data, including Web of Science, PubMed Central, Medline, Embase and Cochrane. Our study examined several randomized controlled trials, including randomized clinical trials and randomized controlled trials that involved TTM interventions in adult OHCA patients. An analysis was conducted based on the search criteria for screening, collecting, and extracting data. Based primarily on qualitative analysis, a synthesis was conducted. There were 21 studies with a total of 11435 participants, with a median sample of 355, and none of them demonstrated sufficient qualitative and quantitative evidence indicating that TTM interventional variants were safe, feasible, efficient, and effective on neurological and mortality outcomes in OHCA patients.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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