H. Mashar, Teguh Supriyono, I. Ismail, Ysrafil Ysrafil, Dali .
The Dayaknese consume Stenochlaena palustris for the treatment of various diseases. The plants contain chemical compounds that have the potential to be developed as antibiotics. This study aimed to isolate endophytic fungi from the leaves and stems of S. palustris, and further identify and assess the isolated endophytic fungi against microorganisms. The research was carried out in several stages, namely, isolation and purification of endophytic fungi, macroscopic and microscopic identification, activity test on isolates, fermentation and extraction of secondary metabolites, and evaluation of the antibacterial activity of the extracts using the disk diffusion method. This experimental laboratory research was conducted in Palangka Raya City, Central Kalimantan, with a test carried out at the Microbiology Laboratory of the Health Polytechnic Ministry of Health, Palangka Raya. The results showed 3 types of endophytic fungi: SpHtm, SpHjk, and Sporn, identified as Aspergillus sp., Paecilomyces sp., and Arthrocristula sp. The antimicrobial effect of the isolated fungi was assessed at various concentrations, i.e., 15, 30, and 45%, against S. aureus and E. coli. The results showed that the ethyl acetate extracts of the SpHtm and SpHjk isolates did not demonstrate any inhibitory response to S. aureus at concentrations of 15, 30, and 45% and did a small inhibitory response to E. coli at an SpHtm concentration of 30% and an SpHjk concentration of 45%, with inhibition zone diameters of 11.63 ± 0.01 and 10.83 ± 0.02 mm, respectively.
{"title":"Exploration of Endophytic Fungi in the Kelakai (Stenochlaena palustris) and Their Antibacterial Effect","authors":"H. Mashar, Teguh Supriyono, I. Ismail, Ysrafil Ysrafil, Dali .","doi":"10.25258/ijpqa.14.2.01","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.01","url":null,"abstract":"The Dayaknese consume Stenochlaena palustris for the treatment of various diseases. The plants contain chemical compounds that have the potential to be developed as antibiotics. This study aimed to isolate endophytic fungi from the leaves and stems of S. palustris, and further identify and assess the isolated endophytic fungi against microorganisms. The research was carried out in several stages, namely, isolation and purification of endophytic fungi, macroscopic and microscopic identification, activity test on isolates, fermentation and extraction of secondary metabolites, and evaluation of the antibacterial activity of the extracts using the disk diffusion method. This experimental laboratory research was conducted in Palangka Raya City, Central Kalimantan, with a test carried out at the Microbiology Laboratory of the Health Polytechnic Ministry of Health, Palangka Raya. The results showed 3 types of endophytic fungi: SpHtm, SpHjk, and Sporn, identified as Aspergillus sp., Paecilomyces sp., and Arthrocristula sp. The antimicrobial effect of the isolated fungi was assessed at various concentrations, i.e., 15, 30, and 45%, against S. aureus and E. coli. The results showed that the ethyl acetate extracts of the SpHtm and SpHjk isolates did not demonstrate any inhibitory response to S. aureus at concentrations of 15, 30, and 45% and did a small inhibitory response to E. coli at an SpHtm concentration of 30% and an SpHjk concentration of 45%, with inhibition zone diameters of 11.63 ± 0.01 and 10.83 ± 0.02 mm, respectively.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48817710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Personalized medicine is a translational approach that utilizes an individual’s genetic profile to guide illness prevention, diagnosis, and treatment choices. The human genome project data is being used to enhance personalized treatment. “Personalised” medicine is beneficial over “individualized” medicine as it suggests that future hazards may be predicted based on the individual’s genes. The advancement of technology for personalized medicine depends heavily on standardization, integration, and harmonization. The scientific practices at various research sites, the connection between science and healthcare, and the relationship between science, healthcare, and broader society, including the legal and ethical paradigms, the dominant cultural and political ethos, and the expectations of patients and citizens - all need to be in harmony. There are several descriptions of the current existing legislation that regulates genetic screening and genomic medical services in various countries around the world, highlighting discrepancies and specifying areas of law where harmonization may be needed to enable the use of individually tailored medication globally. The promise of personalized medicine can only be fulfilled by placing the individual at the centre of personalized medicine and tailoring care to each patient’s unique psychological and social needs in addition to their biological profiles.
{"title":"An Updated Overview on Personalized Medicine: The Next-Gen Paradigm","authors":"Himanshu Sharma, Urmi Bhadouria, Teenu Sharma, Arindam Chatterjee, Parveen Kumar","doi":"10.25258/ijpqa.14.2.34","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.34","url":null,"abstract":"Personalized medicine is a translational approach that utilizes an individual’s genetic profile to guide illness prevention, diagnosis, and treatment choices. The human genome project data is being used to enhance personalized treatment. “Personalised” medicine is beneficial over “individualized” medicine as it suggests that future hazards may be predicted based on the individual’s genes. The advancement of technology for personalized medicine depends heavily on standardization, integration, and harmonization. The scientific practices at various research sites, the connection between science and healthcare, and the relationship between science, healthcare, and broader society, including the legal and ethical paradigms, the dominant cultural and political ethos, and the expectations of patients and citizens - all need to be in harmony. There are several descriptions of the current existing legislation that regulates genetic screening and genomic medical services in various countries around the world, highlighting discrepancies and specifying areas of law where harmonization may be needed to enable the use of individually tailored medication globally. The promise of personalized medicine can only be fulfilled by placing the individual at the centre of personalized medicine and tailoring care to each patient’s unique psychological and social needs in addition to their biological profiles.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45827413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Data integrity is critical to the pharmaceutical industry, ensuring the reliability, accuracy, and consistency of data generated throughout the product lifecycle. However, data integrity violations have been a growing concern, potentially compromising pharmaceutical products’ safety, efficacy, and quality. This systematic review aims to provide an overview of data integrity violations in the pharmaceutical industry and examine the regulatory measures implemented to address this issue. Through a comprehensive analysis of literature, this review highlights the root causes of data integrity violations, the impact on patient safety and public health, and the regulatory landscape governing data integrity in the pharmaceutical industry. It is essential for pharmaceutical companies to prioritize data integrity as an integral part of their operations, from research and development to manufacturing, clinical trials, and post-marketing surveillance. By implementing robust data integrity practices and adhering to regulatory requirements, pharmaceutical companies can protect patient welfare, maintain regulatory compliance, and sustain public trust in the industry.
{"title":"Data Integrity Violations in the Pharmaceutical Industry and Regulatory Measures","authors":"M. H. Ingale, M. Tayade, Y. P. Patil, R. Salunkhe","doi":"10.25258/ijpqa.14.2.29","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.29","url":null,"abstract":"Data integrity is critical to the pharmaceutical industry, ensuring the reliability, accuracy, and consistency of data generated throughout the product lifecycle. However, data integrity violations have been a growing concern, potentially compromising pharmaceutical products’ safety, efficacy, and quality. This systematic review aims to provide an overview of data integrity violations in the pharmaceutical industry and examine the regulatory measures implemented to address this issue. Through a comprehensive analysis of literature, this review highlights the root causes of data integrity violations, the impact on patient safety and public health, and the regulatory landscape governing data integrity in the pharmaceutical industry. It is essential for pharmaceutical companies to prioritize data integrity as an integral part of their operations, from research and development to manufacturing, clinical trials, and post-marketing surveillance. By implementing robust data integrity practices and adhering to regulatory requirements, pharmaceutical companies can protect patient welfare, maintain regulatory compliance, and sustain public trust in the industry.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43643690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cosmetic creams for the antioxidant activity of Punica granutum L seed oil (PSO) were formulated in different concentrations of oil in F1 to F6 formulations of cosmetic creams and their physicochemical properties were evaluated. There are several different pharmacological actions attributed to P. granutum L seed oil. The prepared cream was evaluated its properties like pH, resistance to flow, spreadability size, and surface charge value, and ex-vivo release study were performed. All results are found within the limit and it complies with the specification as per requirements. Good in-vitro DPPH scavenging activity was observed from the optimized batches throughout the preparation. To determine the stability profile, cosmetic creams containing PSO (Batches F1 through F6) were exposed to a three-month accelerated stability study in accordance with ICH recommendations. From this study it was concluded that prepared batches used for various treatments of skin disorders.
{"title":"Formulation and Evaluation of Punica granatum L Seed Oil-loaded Cosmetic Cream: Its In-vitro Antioxidant Activity","authors":"Shrishail M. Ghurghure, A. Phatak","doi":"10.25258/ijpqa.14.2.08","DOIUrl":"https://doi.org/10.25258/ijpqa.14.2.08","url":null,"abstract":"Cosmetic creams for the antioxidant activity of Punica granutum L seed oil (PSO) were formulated in different concentrations of oil in F1 to F6 formulations of cosmetic creams and their physicochemical properties were evaluated. There are several different pharmacological actions attributed to P. granutum L seed oil. The prepared cream was evaluated its properties like pH, resistance to flow, spreadability size, and surface charge value, and ex-vivo release study were performed. All results are found within the limit and it complies with the specification as per requirements. Good in-vitro DPPH scavenging activity was observed from the optimized batches throughout the preparation. To determine the stability profile, cosmetic creams containing PSO (Batches F1 through F6) were exposed to a three-month accelerated stability study in accordance with ICH recommendations. From this study it was concluded that prepared batches used for various treatments of skin disorders.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43731289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Drugs are distinctive and sensitive products. It should pass specifi c tests and have specifi c criteria for human use. The disparity of any of the acceptance criteria will infl uence the product’s eff ectiveness, despite the product being still in validated expiry date. The stability study and manufacturing of many drugs were done at specifi c climatic zones, but marketed and sold at diff erent climatic zones. In a hot poor country or country that suff ers from a power supply shortage (like in Iraq), it is impossible to provide standard storage conditions as the manufacturer recommends. The research aims to study the eff ects of nonstandard storage conditions on the offi cial and non-offi cial acceptance criteria for stored tablets compared to the same newly manufactured tablets. The results showed that the physical appearance, tablet hardness, friability, disintegration, uniformity of weight, assay was not aff ected. On the other hand, the dissolution profi le of the stored products showed a change in the solubility behavior. From the results, we can conclude that storage conditions may not aff ect the content of the active substance. Still, it may aff ect other characteristics of the active substance, such as solubility. The research recommends the necessity of scrutiny of the storage conditions of drugs and not being lenient with them. Also recommends the necessity to study the dissolution profi le and stability of excipients when conducting a drug stability study and determining the expiry date.
{"title":"Eff ects of Non-standard Storage Conditions on the Stability, Safety and Suitability of Drug Consumption","authors":"Alsammarraie ., H. Mahdi","doi":"10.25258/ijpqa.14.1.19","DOIUrl":"https://doi.org/10.25258/ijpqa.14.1.19","url":null,"abstract":"Drugs are distinctive and sensitive products. It should pass specifi c tests and have specifi c criteria for human use. The disparity of any of the acceptance criteria will infl uence the product’s eff ectiveness, despite the product being still in validated expiry date. The stability study and manufacturing of many drugs were done at specifi c climatic zones, but marketed and sold at diff erent climatic zones. In a hot poor country or country that suff ers from a power supply shortage (like in Iraq), it is impossible to provide standard storage conditions as the manufacturer recommends. The research aims to study the eff ects of nonstandard storage conditions on the offi cial and non-offi cial acceptance criteria for stored tablets compared to the same newly manufactured tablets. The results showed that the physical appearance, tablet hardness, friability, disintegration, uniformity of weight, assay was not aff ected. On the other hand, the dissolution profi le of the stored products showed a change in the solubility behavior. From the results, we can conclude that storage conditions may not aff ect the content of the active substance. Still, it may aff ect other characteristics of the active substance, such as solubility. The research recommends the necessity of scrutiny of the storage conditions of drugs and not being lenient with them. Also recommends the necessity to study the dissolution profi le and stability of excipients when conducting a drug stability study and determining the expiry date.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48203358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karia P Pradeep, Ayre A Pandurang, Bhagyawant P Baburao, Nair D Divakaran
A rapid, cost-eff ective and simple “RP-HPLC method with UV detection” was developed for the determination of zileuton from human plasma. The method involved spiking human plasma and validation. Phenacetin (internal standard) and zileuton samples were prepared using LLE in diethyl ether which was used as solvent for extraction. “HiQsil C18 column (250 mm*4.6 mm* 5 m) was used for separation with tetrahydrofuran: water (45:55, v/v) as mobile phase. The fl ow rate was set at 1-mL/min and UV detection was done at 230 nm. Zileuton showed excellent separation from the internal standard and no interference was observed in plasma samples. A linear calibration curve was obtained in the 500 to 10,000 ng/mL range. The relative error (RE) and relative standard deviation (RSD) were found to be less than 15% for both within the run and between the runs. At lower zileuton concentrations, “weighted least square regression with a weighting factor of 1/X was used to reduce the heteroscedastic eff ect”. Extraction effi ciency of LLE method was confi rmed by the recovery of zileuton from samples. The stability data showed that “zileuton was stable in human plasma for 6 hours at room temperature for 30 days at -20°C after freeze thaw cycles”.
{"title":"Quantitative Determination of Zileuton from Spiked Human Plasma Using Liquid-Liquid Extraction Followed by RP-HPLC and UV Analysis","authors":"Karia P Pradeep, Ayre A Pandurang, Bhagyawant P Baburao, Nair D Divakaran","doi":"10.25258/ijpqa.14.1.01","DOIUrl":"https://doi.org/10.25258/ijpqa.14.1.01","url":null,"abstract":"A rapid, cost-eff ective and simple “RP-HPLC method with UV detection” was developed for the determination of zileuton from human plasma. The method involved spiking human plasma and validation. Phenacetin (internal standard) and zileuton samples were prepared using LLE in diethyl ether which was used as solvent for extraction. “HiQsil C18 column (250 mm*4.6 mm* 5 m) was used for separation with tetrahydrofuran: water (45:55, v/v) as mobile phase. The fl ow rate was set at 1-mL/min and UV detection was done at 230 nm. Zileuton showed excellent separation from the internal standard and no interference was observed in plasma samples. A linear calibration curve was obtained in the 500 to 10,000 ng/mL range. The relative error (RE) and relative standard deviation (RSD) were found to be less than 15% for both within the run and between the runs. At lower zileuton concentrations, “weighted least square regression with a weighting factor of 1/X was used to reduce the heteroscedastic eff ect”. Extraction effi ciency of LLE method was confi rmed by the recovery of zileuton from samples. The stability data showed that “zileuton was stable in human plasma for 6 hours at room temperature for 30 days at -20°C after freeze thaw cycles”.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41362549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Vanukuru, G. R. Mudunuri, Prathyusha Bhimasani, Niharika Malipatel, Mahesh Thorat, H. Tare
Ethanolic extract aerial portions of Coriandrum sativum (EECS) were tested for their anxiolytic eff ects on the cold-resistant stress test after seven days of treatment and their cognitive boosting eff ects after eight days of therapy (EECS). Total phenolic content and fl avonoid compound levels were calculated. C. sativum showed anti-stress effi cacy in a cold-resistant stress animal at 200 and 400 mg/kg doses. The plasma glucose, triglyceride, cholesterol levels, as well as the weight of the adrenal glands are all aff ected by the stimulation of the HPA in stressful situations. Pre-treatment with EECS and Geriforte, which contain secondary metabolites such as fl avonoids, glycosides, triterpenoids, and phenolic compounds, signifi cantly reduced stress-induced changes in these biochemical levels in cold stress animals. Screening for acetylcholinesterase inhibition activity in-vitro using Ellman’s approach increased AChE inhibition dose-dependently in the brains of mice. The data proved that the extract’s potential to reduce pain in-vitro is what led to the observed cognitive benefi ts in-vivo. Animals given EECS at 200 and 400 mg/kg had their infl exion ratio improved as a result of the memory defi cit being reversed. The scopolamine-induced amnesia group of mice showed degeneration of vacuolated cells, pyramidal cells, pyknosis, loss of architecture and the creation of lesions in the hippocampus; however, these characteristics were restored by EECS and standard therapy. Eff ective docking scores in mcule software were observed for interactions with receptors PDB: 4K5Y (CRF-1) for adaptogenic and PDB: 1E66 (AChE) for cognition, according to in-silico research. The ethanolic extract of C. sativum has been shown to have positive and scientifi cally-supported eff ects on human health when used as a nutraceutical, with the in-vitro acetylcholinesterase Inhibition assay, anti-stress, and cognitive enhancement activities, and in-silico studies all corroborated by this study.
{"title":"Pre-clinical Evaluation and In-silico Docking of Coriandrum sativum on Stress and Cognitive Defi cits in Rodents","authors":"N. Vanukuru, G. R. Mudunuri, Prathyusha Bhimasani, Niharika Malipatel, Mahesh Thorat, H. Tare","doi":"10.25258/ijpqa.14.1.08","DOIUrl":"https://doi.org/10.25258/ijpqa.14.1.08","url":null,"abstract":"Ethanolic extract aerial portions of Coriandrum sativum (EECS) were tested for their anxiolytic eff ects on the cold-resistant stress test after seven days of treatment and their cognitive boosting eff ects after eight days of therapy (EECS). Total phenolic content and fl avonoid compound levels were calculated. C. sativum showed anti-stress effi cacy in a cold-resistant stress animal at 200 and 400 mg/kg doses. The plasma glucose, triglyceride, cholesterol levels, as well as the weight of the adrenal glands are all aff ected by the stimulation of the HPA in stressful situations. Pre-treatment with EECS and Geriforte, which contain secondary metabolites such as fl avonoids, glycosides, triterpenoids, and phenolic compounds, signifi cantly reduced stress-induced changes in these biochemical levels in cold stress animals. Screening for acetylcholinesterase inhibition activity in-vitro using Ellman’s approach increased AChE inhibition dose-dependently in the brains of mice. The data proved that the extract’s potential to reduce pain in-vitro is what led to the observed cognitive benefi ts in-vivo. Animals given EECS at 200 and 400 mg/kg had their infl exion ratio improved as a result of the memory defi cit being reversed. The scopolamine-induced amnesia group of mice showed degeneration of vacuolated cells, pyramidal cells, pyknosis, loss of architecture and the creation of lesions in the hippocampus; however, these characteristics were restored by EECS and standard therapy. Eff ective docking scores in mcule software were observed for interactions with receptors PDB: 4K5Y (CRF-1) for adaptogenic and PDB: 1E66 (AChE) for cognition, according to in-silico research. The ethanolic extract of C. sativum has been shown to have positive and scientifi cally-supported eff ects on human health when used as a nutraceutical, with the in-vitro acetylcholinesterase Inhibition assay, anti-stress, and cognitive enhancement activities, and in-silico studies all corroborated by this study.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49357380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Preety Thokchom, L. Sharma, D. Sharma, G.D. Ghangale, J. Bidkar, H. Tare
Adolescents are the greatest group of a young star in history, ranging in age from 10 to 19. Around 1.8 billion young people live on the earth, with 90% of them in low- and middle-income countries. Even as obesity is on the rise in many contexts, infectious and injury-related disorders are the leading causes of disease in children. However, dietary defi ciencies, poor linear development, and under nutrition are serious public health challenges. Girls are particularly in danger due to developmental and gender roles that diff erentiate them adversely. Adolescent fi tness and nutritional well-being are infl uenced by dietary and physical activity choices, education, and competing for social demands for early marriage. It is necessary to meet all nutrient requirements. Expand for energy, protein, iron, calcium, and other nutrients early in life to aid proper growth and development. Anemia and vitamin shortages are common in areas where food consumption is insuffi cient. Endocrine factors are aff ected by poor diet and play a role in adolescent growth. Once top peak velocity is reached and catch-up is possible, growth speed accelerates throughout adolescence; in girls, roughly 15–25% of the adult peak is achieved. Premature birth can lay off linear to direct growth and add the chance of a poor birth result. Massive data gaps in nutrition and growth during adolescence must be fi lled, as well as interventions tested during the second window of a good time to perfect the growth and development in children
{"title":"The Eff ects of Nutritional Defi ciency During Adolescence and the Need for Supplementation: A Review","authors":"Preety Thokchom, L. Sharma, D. Sharma, G.D. Ghangale, J. Bidkar, H. Tare","doi":"10.25258/ijpqa.14.1.39","DOIUrl":"https://doi.org/10.25258/ijpqa.14.1.39","url":null,"abstract":"Adolescents are the greatest group of a young star in history, ranging in age from 10 to 19. Around 1.8 billion young people live on the earth, with 90% of them in low- and middle-income countries. Even as obesity is on the rise in many contexts, infectious and injury-related disorders are the leading causes of disease in children. However, dietary defi ciencies, poor linear development, and under nutrition are serious public health challenges. Girls are particularly in danger due to developmental and gender roles that diff erentiate them adversely. Adolescent fi tness and nutritional well-being are infl uenced by dietary and physical activity choices, education, and competing for social demands for early marriage. It is necessary to meet all nutrient requirements. Expand for energy, protein, iron, calcium, and other nutrients early in life to aid proper growth and development. Anemia and vitamin shortages are common in areas where food consumption is insuffi cient. Endocrine factors are aff ected by poor diet and play a role in adolescent growth. Once top peak velocity is reached and catch-up is possible, growth speed accelerates throughout adolescence; in girls, roughly 15–25% of the adult peak is achieved. Premature birth can lay off linear to direct growth and add the chance of a poor birth result. Massive data gaps in nutrition and growth during adolescence must be fi lled, as well as interventions tested during the second window of a good time to perfect the growth and development in children","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47675696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Baraa Adil, S. Shahar, S. Amran, M. S. S. Omar, M. A. Naser
Ghrelin is a peptide hormone made up of 28 amino acids. It is involved in various biological processes, including the stimulation of growth hormone release, control of food intake, and metabolic and cytoprotective eff ects. In 1999, this hormone was identifi ed as a ligand for the GHSR1a growth hormone secretagogue receptor. Ghrelin hormone-receptor complexes have been modeled in a few previous in-silico studies, but none of them have investigated the eff ects of the gene variation rs34911341/(R51Q) on the full-length ghrelin model and on the hormone-receptor binding. It was established that the full-length ghrelin model’s secondary structure was unaff ected by the R to Q amino acid substitution. Additionally, the mutant hormone-receptor complex exhibited better outcomes and altered the molecular interactions between the mutant ligand and the receptor by creating novel interactions, according to the post-molecular dynamic simulation analysis.
{"title":"Computational Investigation of the Impact of the Ghrelin Hormone Gene Variation (R51q) on the Hormone-receptor Binding Pattern","authors":"Baraa Adil, S. Shahar, S. Amran, M. S. S. Omar, M. A. Naser","doi":"10.25258/ijpqa.14.1.34","DOIUrl":"https://doi.org/10.25258/ijpqa.14.1.34","url":null,"abstract":"Ghrelin is a peptide hormone made up of 28 amino acids. It is involved in various biological processes, including the stimulation of growth hormone release, control of food intake, and metabolic and cytoprotective eff ects. In 1999, this hormone was identifi ed as a ligand for the GHSR1a growth hormone secretagogue receptor. Ghrelin hormone-receptor complexes have been modeled in a few previous in-silico studies, but none of them have investigated the eff ects of the gene variation rs34911341/(R51Q) on the full-length ghrelin model and on the hormone-receptor binding. It was established that the full-length ghrelin model’s secondary structure was unaff ected by the R to Q amino acid substitution. Additionally, the mutant hormone-receptor complex exhibited better outcomes and altered the molecular interactions between the mutant ligand and the receptor by creating novel interactions, according to the post-molecular dynamic simulation analysis.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48429455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Essential oils include Vitex negundo Linn. It is used in the treatment of eye diseases, toothache, redness, white spots, splenomegaly, skin ulcers, catarrh, rheumatoid arthritis, gonorrhea and bronchitis. It is also used as a tonic, insect repellent, emulsifi er, menstrual aid, antibacterial, antipyretic and antihistamine. Preparations from plant parts of V. negundo treat a variety of ailments, including rheumatic diseases, arthritis, gout, cervicitis, infl ammatory diseases of the musculoskeletal system, hemorrhoids (thousands), rheumatic pains, sprains and toothaches. It has been used commercially for miles in various Ayurvedic remedies and ointments to treat wounds, burns, and fungal skin infections. We concluded from in vitro drug delivery studies that latex composed of HPMC polymers facilitates controlled release of drugs over long periods of time, avoids further fl uctuations, and reduces treatment costs. This new class of drug delivery is gaining popularity due to the spreadability, adhesion, viscosity and extrudability properties of emulgel, which makes topical application of hydrophobic pills desirable for every near and systemic eff ect.
{"title":"Development of the Formulation and Evaluation of the Anti-infl ammatory Activity of Vitex negundo Gel and Latex","authors":"Jeevan R. Rajguru, M. Shirsat, Sampat D Navale","doi":"10.25258/ijpqa.14.1.27","DOIUrl":"https://doi.org/10.25258/ijpqa.14.1.27","url":null,"abstract":"Essential oils include Vitex negundo Linn. It is used in the treatment of eye diseases, toothache, redness, white spots, splenomegaly, skin ulcers, catarrh, rheumatoid arthritis, gonorrhea and bronchitis. It is also used as a tonic, insect repellent, emulsifi er, menstrual aid, antibacterial, antipyretic and antihistamine. Preparations from plant parts of V. negundo treat a variety of ailments, including rheumatic diseases, arthritis, gout, cervicitis, infl ammatory diseases of the musculoskeletal system, hemorrhoids (thousands), rheumatic pains, sprains and toothaches. It has been used commercially for miles in various Ayurvedic remedies and ointments to treat wounds, burns, and fungal skin infections. We concluded from in vitro drug delivery studies that latex composed of HPMC polymers facilitates controlled release of drugs over long periods of time, avoids further fl uctuations, and reduces treatment costs. This new class of drug delivery is gaining popularity due to the spreadability, adhesion, viscosity and extrudability properties of emulgel, which makes topical application of hydrophobic pills desirable for every near and systemic eff ect.","PeriodicalId":14260,"journal":{"name":"International Journal of Pharmaceutical Quality Assurance","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46083135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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