Pub Date : 2024-07-25DOI: 10.18203/issn.2454-2156.intjscirep20241991
Mohammed Saifuddin Munna, Tuton Chandra Mallick
Background: With the rapid advancement of machine learning technology, there is a growing interest in integrating it into IoT systems for enhanced functionality. In this study, we propose a SMART Weight Machine system designed to detect, weigh, and price various objects using machine learning techniques. Methods: Our system utilizes TensorFlow, a machine learning framework, in conjunction with Raspberry Pi for object recognition. Image processing is performed locally on the Raspberry Pi for efficient detection. The system also incorporates MySQL for database management and a WebApp developed using PHP and Laravel for the user interface. Results: Through our implementation, we achieved significant improvements in speed and accuracy. TensorFlow's compatibility with microcontroller devices like Raspberry Pi enabled swift processing, resulting in a 96% accuracy rate for object detection during our evaluation. Conclusions: The SMART Weight Machine system demonstrates promising potential for real-world applications. Moving forward, rigorous testing and quality assurance will be conducted to ensure the reliability and accuracy of the system during the development phase.
背景：随着机器学习技术的快速发展，人们对将其集成到物联网系统中以增强功能的兴趣与日俱增。在本研究中，我们提出了一种 SMART 重量机系统，旨在利用机器学习技术检测、称重和为各种物体定价：我们的系统利用机器学习框架 TensorFlow 和 Raspberry Pi 进行物体识别。图像处理在 Raspberry Pi 上本地进行，以提高检测效率。系统还采用 MySQL 进行数据库管理，并使用 PHP 和 Laravel 开发了一个 WebApp，用于用户界面。 结果通过实施，我们在速度和准确性方面都取得了显著提高。TensorFlow 与树莓派（Raspberry Pi）等微控制器设备的兼容性实现了快速处理，在我们的评估中，物体检测的准确率达到 96%：SMART Weight Machine 系统在实际应用中展现出了巨大的潜力。今后，我们将在开发阶段进行严格的测试和质量保证，以确保系统的可靠性和准确性。
{"title":"Transforming weight measurement: a cutting-edge IoT-enabled smart weight machine for centralized price control of products","authors":"Mohammed Saifuddin Munna, Tuton Chandra Mallick","doi":"10.18203/issn.2454-2156.intjscirep20241991","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20241991","url":null,"abstract":"Background: With the rapid advancement of machine learning technology, there is a growing interest in integrating it into IoT systems for enhanced functionality. In this study, we propose a SMART Weight Machine system designed to detect, weigh, and price various objects using machine learning techniques.\u0000Methods: Our system utilizes TensorFlow, a machine learning framework, in conjunction with Raspberry Pi for object recognition. Image processing is performed locally on the Raspberry Pi for efficient detection. The system also incorporates MySQL for database management and a WebApp developed using PHP and Laravel for the user interface. \u0000Results: Through our implementation, we achieved significant improvements in speed and accuracy. TensorFlow's compatibility with microcontroller devices like Raspberry Pi enabled swift processing, resulting in a 96% accuracy rate for object detection during our evaluation.\u0000Conclusions: The SMART Weight Machine system demonstrates promising potential for real-world applications. Moving forward, rigorous testing and quality assurance will be conducted to ensure the reliability and accuracy of the system during the development phase.","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141802448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-25DOI: 10.18203/issn.2454-2156.intjscirep20241990
Shahinur Parvin, Murshida, M. A. Rahman, Sharmin Akter Sumi, Stephen Kpekura, Zeshaan Yahaya Haji Mahmood, M. A. Ali
Background: Nurses are important health caregivers in Bangladesh. They help to improve health-facilities every day and reach it to helpless people. This study aimed to assess the responsibilities of professional nurses in public health hospitals. Methods: The descriptive cross-sectional study conducted at Rajshahi Medical College (RMCH), Bangladesh from 18 September 2018 to 19 February 2019 included 300 individuals with following inclusion and exclusion criteria. A pre-tested questionnaire was used as a tool for data collection. Results: Majority of participants age range of 31-40y 46.33%, 41-50y 27%, 20-30y, and 51-60y 19% and 7.67%, respectively. Moreover, Female are 96.33% and males constitute only 7.74%. Based on religion, Muslim 87%, Hindu 10%, Christian 1.67%, and Buddhist 1.33%. Beginning of education, diploma was compared to very few with advanced training for instance Master's and Ph.D. 38.67% nurses were 1-5 years of experience. But only 11 had ≥21 years of experience. A significant portion, 48.02%, had a good level of assessment of patients and 36.67% of individuals excelled at a high level of proficiency. While only 2% showed an inferior level of patient assessment. Improvement of quality care, the majority of respondents 48.33% good, 17.67% excellent, 21.67% average, and 3.33% poor quality care. Conclusions: Nurses are the key element of the healthcare system. The study outcomes showing their best to provide quality service despite of lack of resources. If the responsible authority has a deep look at this domain, in the future they could make a role model in Bangladesh.
{"title":"A closer observation of the dedicated responsibilities of nurses at public hospitals in Bangladesh","authors":"Shahinur Parvin, Murshida, M. A. Rahman, Sharmin Akter Sumi, Stephen Kpekura, Zeshaan Yahaya Haji Mahmood, M. A. Ali","doi":"10.18203/issn.2454-2156.intjscirep20241990","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20241990","url":null,"abstract":"Background: Nurses are important health caregivers in Bangladesh. They help to improve health-facilities every day and reach it to helpless people. This study aimed to assess the responsibilities of professional nurses in public health hospitals.\u0000Methods: The descriptive cross-sectional study conducted at Rajshahi Medical College (RMCH), Bangladesh from 18 September 2018 to 19 February 2019 included 300 individuals with following inclusion and exclusion criteria. A pre-tested questionnaire was used as a tool for data collection. \u0000Results: Majority of participants age range of 31-40y 46.33%, 41-50y 27%, 20-30y, and 51-60y 19% and 7.67%, respectively. Moreover, Female are 96.33% and males constitute only 7.74%. Based on religion, Muslim 87%, Hindu 10%, Christian 1.67%, and Buddhist 1.33%. Beginning of education, diploma was compared to very few with advanced training for instance Master's and Ph.D. 38.67% nurses were 1-5 years of experience. But only 11 had ≥21 years of experience. A significant portion, 48.02%, had a good level of assessment of patients and 36.67% of individuals excelled at a high level of proficiency. While only 2% showed an inferior level of patient assessment. Improvement of quality care, the majority of respondents 48.33% good, 17.67% excellent, 21.67% average, and 3.33% poor quality care.\u0000Conclusions: Nurses are the key element of the healthcare system. The study outcomes showing their best to provide quality service despite of lack of resources. If the responsible authority has a deep look at this domain, in the future they could make a role model in Bangladesh.","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"30 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141803104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-25DOI: 10.18203/issn.2454-2156.intjscirep20241993
Rogers Sekabira, Godwin Murungi, Nigel Okot Kirinya, M. Kisekka, Violet Korutaro, Patricia Ntege Nahirya, A. Kekitiinwa
This review article provides information on the role of clinical research site (CRS) Pharmacies in supporting the division of AIDS (DAIDS)-sponsored clinical trials at the CRS, their legislative framework, and how they differ from community pharmacies. These pharmacies are relatively few, and little information is available about their operation, setup, and requirements in low-and middle-income countries (LMICs). The information in this article is pertinent to pharmacy associations and regulators who formulate policies and guidelines and to pharmacy professionals eager to enhance their skills and competencies through knowledge sharing to improve the quality of healthcare services. Moreover, this information is relevant in establishing a CRS pharmacy and understanding its interaction with various administrative and financial institutions. This article provides information on how CRS pharmacies achieve uninterrupted power supply for investigational medicinal products (IMP) throughout the year, the sponsor and regulatory requirements for the CRS pharmacy and the processes for IMP shipment, from its dispensation to the study participants. The article also provides information on quality control and assurance processes for maintaining a CRS pharmacy. CRS pharmacies in LMICs have unique requirements, operations, services, and setups, and regulatory authorities must develop policies and guidelines that align with these distinct features. More so, leveraging the existing CRS pharmacies to disseminate skills and knowledge to trainees, community pharmacies, and other medicine outlets can significantly enhance the quality of health services delivered to the community.
{"title":"A clinical research site pharmacy for the division of AIDS sponsored clinical trials in a low middle income country","authors":"Rogers Sekabira, Godwin Murungi, Nigel Okot Kirinya, M. Kisekka, Violet Korutaro, Patricia Ntege Nahirya, A. Kekitiinwa","doi":"10.18203/issn.2454-2156.intjscirep20241993","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20241993","url":null,"abstract":"This review article provides information on the role of clinical research site (CRS) Pharmacies in supporting the division of AIDS (DAIDS)-sponsored clinical trials at the CRS, their legislative framework, and how they differ from community pharmacies. These pharmacies are relatively few, and little information is available about their operation, setup, and requirements in low-and middle-income countries (LMICs). The information in this article is pertinent to pharmacy associations and regulators who formulate policies and guidelines and to pharmacy professionals eager to enhance their skills and competencies through knowledge sharing to improve the quality of healthcare services. Moreover, this information is relevant in establishing a CRS pharmacy and understanding its interaction with various administrative and financial institutions. This article provides information on how CRS pharmacies achieve uninterrupted power supply for investigational medicinal products (IMP) throughout the year, the sponsor and regulatory requirements for the CRS pharmacy and the processes for IMP shipment, from its dispensation to the study participants. The article also provides information on quality control and assurance processes for maintaining a CRS pharmacy. CRS pharmacies in LMICs have unique requirements, operations, services, and setups, and regulatory authorities must develop policies and guidelines that align with these distinct features. More so, leveraging the existing CRS pharmacies to disseminate skills and knowledge to trainees, community pharmacies, and other medicine outlets can significantly enhance the quality of health services delivered to the community.","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"12 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141804451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-25DOI: 10.18203/issn.2454-2156.intjscirep20241996
M. H. Shuja, A. F. Abbasi, Firzah Shakil
Rytelo (Imetelstat), approved by the FDA in June 2024, offers a groundbreaking treatment for patients with transfusion-dependent anemia due to lower-risk myelodysplastic syndromes (MDS). Rytelo is a first-in-class telomerase inhibitor that targets telomerase, an enzyme that cancer cells use to maintain their telomeres and continue proliferating. By inhibiting telomerase, Rytelo induces apoptosis in malignant cells in the bone marrow, thus reducing the need for frequent blood transfusions. Administered intravenously every four weeks, clinical trials have shown Rytelo effectively lowers transfusion requirements and enhances patients' quality of life. However, common side effects such as neutropenia and thrombocytopenia require careful monitoring and dose adjustments to manage. Despite these challenges, Rytelo represents a significant advancement in treating transfusion-dependent anemia in MDS, providing a novel therapeutic option that addresses the underlying cause of the disease and improves patient outcomes.
{"title":"Rytelo: a novel option for transfusion-dependent anemia in myelodysplastic syndromes","authors":"M. H. Shuja, A. F. Abbasi, Firzah Shakil","doi":"10.18203/issn.2454-2156.intjscirep20241996","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20241996","url":null,"abstract":"Rytelo (Imetelstat), approved by the FDA in June 2024, offers a groundbreaking treatment for patients with transfusion-dependent anemia due to lower-risk myelodysplastic syndromes (MDS). Rytelo is a first-in-class telomerase inhibitor that targets telomerase, an enzyme that cancer cells use to maintain their telomeres and continue proliferating. By inhibiting telomerase, Rytelo induces apoptosis in malignant cells in the bone marrow, thus reducing the need for frequent blood transfusions. Administered intravenously every four weeks, clinical trials have shown Rytelo effectively lowers transfusion requirements and enhances patients' quality of life. However, common side effects such as neutropenia and thrombocytopenia require careful monitoring and dose adjustments to manage. Despite these challenges, Rytelo represents a significant advancement in treating transfusion-dependent anemia in MDS, providing a novel therapeutic option that addresses the underlying cause of the disease and improves patient outcomes.","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"27 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141805951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-25DOI: 10.18203/issn.2454-2156.intjscirep20241995
Muhammad Hamza Gul, Abdul Baseer Wardak, Aiman Waheed
Small cell lung cancer (SCLC) constitutes 10% of lung cancer. It is the leading cause of death due to cancer in men and the second most prevalent cause of cancer related death in women worldwide. It is an extremely hostile tumor with early development, spread, and fatal as it is typically found too late. Early-stage patients are usually treated with chemotherapy and thoracic radiation and surgery is rarely used to treat this malignancy. The addition of immunotherapy to first-line chemotherapy has improved survival for the first time in the decennary. It has demonstrated promise in producing significant, long-lasting responses. The disease is still challenging to treat but adding radiation therapy to a patient's care at certain intervals may enhance illness control. Platinum-based chemotherapy is initially quite effective, eliciting prompt and often substantial responses, however, they are transient effects, and when SCLC recurs, treatment resistance is strong.
{"title":"Navigating a paradigm shift; food and drug administration approved Tarlatamab-dlle redefining the landscape of small cell lung cancer therapy","authors":"Muhammad Hamza Gul, Abdul Baseer Wardak, Aiman Waheed","doi":"10.18203/issn.2454-2156.intjscirep20241995","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20241995","url":null,"abstract":"Small cell lung cancer (SCLC) constitutes 10% of lung cancer. It is the leading cause of death due to cancer in men and the second most prevalent cause of cancer related death in women worldwide. It is an extremely hostile tumor with early development, spread, and fatal as it is typically found too late. Early-stage patients are usually treated with chemotherapy and thoracic radiation and surgery is rarely used to treat this malignancy. The addition of immunotherapy to first-line chemotherapy has improved survival for the first time in the decennary. It has demonstrated promise in producing significant, long-lasting responses. The disease is still challenging to treat but adding radiation therapy to a patient's care at certain intervals may enhance illness control. Platinum-based chemotherapy is initially quite effective, eliciting prompt and often substantial responses, however, they are transient effects, and when SCLC recurs, treatment resistance is strong.","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"44 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141803979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-25DOI: 10.18203/issn.2454-2156.intjscirep20241994
D. Sharma, Gaurav Thakur, D. Gurung, Amrita Thakur
Orthodontic intrusion is a common treatment approach in managing orthodontic esthetic and functional problems. Intrusion often constitutes an integral part of orthodontic treatment in order to improve sagittal and vertical incisor relationships. In this article we are trying to review all the appliances in a manner of their evolution, beginning from removal appliances used initially, discussing role of functional appliances, head gears, intrusion arches, implants, magnets and surgical procedures etc. in treatment of intrusion.
{"title":"Orthodontic treatment modalities of intrusion: a review","authors":"D. Sharma, Gaurav Thakur, D. Gurung, Amrita Thakur","doi":"10.18203/issn.2454-2156.intjscirep20241994","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20241994","url":null,"abstract":"Orthodontic intrusion is a common treatment approach in managing orthodontic esthetic and functional problems. Intrusion often constitutes an integral part of orthodontic treatment in order to improve sagittal and vertical incisor relationships. In this article we are trying to review all the appliances in a manner of their evolution, beginning from removal appliances used initially, discussing role of functional appliances, head gears, intrusion arches, implants, magnets and surgical procedures etc. in treatment of intrusion. ","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"17 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141804347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-25DOI: 10.18203/issn.2454-2156.intjscirep20241992
Marzieh Azami, Mahdi Karbasian, Sareh Yousefian
Background: In today's competitive industrial landscape, companies are focusing on developing diverse product portfolios to maintain a competitive edge. This trend has led to the adoption of product portfolio strategies aimed at enhancing customer satisfaction and optimizing resource utilization. Methods: This study introduces a model to enhance the design of weather radar products by integrating DEMATEL and Goal Programming (GP). The methodology involves identifying key indicators of variety in weather radar design, assessing component interdependencies, and determining component weightage for optimal functionality and cost-effectiveness. Results: The DEMATEL and GP approach proved effective in optimizing the product family structure for weather radar systems. Key results include the identification and prioritization of variety indicators, evaluation of component interdependencies, and determination of component weightage, resulting in a more precise and operational design. Conclusions: The proposed model for weather radar variety enhances customer satisfaction, meets market demands, and addresses the challenges of dynamic customer needs. This methodology offers valuable insights into managing product variety and complexity, enabling designers to quickly adapt to evolving customer requirements.
背景：在当今竞争激烈的行业环境中，企业正致力于开发多样化的产品组合，以保持竞争优势。这一趋势促使企业采用产品组合战略，旨在提高客户满意度和优化资源利用率：本研究引入了一个模型，通过整合 DEMATEL 和目标编程 (GP) 来加强天气雷达产品的设计。该方法包括确定天气雷达设计的关键指标、评估组件的相互依赖关系以及确定组件的权重，以实现最佳功能和成本效益。 结果：事实证明，DEMATEL 和 GP 方法能有效优化天气雷达系统的产品系列结构。主要结果包括识别和优先考虑品种指标、评估组件的相互依赖关系以及确定组件的权重，从而使设计更精确、更具可操作性：结论：所提出的天气雷达多样性模型可提高客户满意度，满足市场需求，并应对客户动态需求的挑战。该方法为管理产品的多样性和复杂性提供了宝贵的见解，使设计人员能够快速适应不断变化的客户需求。
{"title":"Enhancing competitive advantage through a strategic product portfolio and design for variety in weather radar products","authors":"Marzieh Azami, Mahdi Karbasian, Sareh Yousefian","doi":"10.18203/issn.2454-2156.intjscirep20241992","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20241992","url":null,"abstract":"Background: In today's competitive industrial landscape, companies are focusing on developing diverse product portfolios to maintain a competitive edge. This trend has led to the adoption of product portfolio strategies aimed at enhancing customer satisfaction and optimizing resource utilization.\u0000Methods: This study introduces a model to enhance the design of weather radar products by integrating DEMATEL and Goal Programming (GP). The methodology involves identifying key indicators of variety in weather radar design, assessing component interdependencies, and determining component weightage for optimal functionality and cost-effectiveness. \u0000Results: The DEMATEL and GP approach proved effective in optimizing the product family structure for weather radar systems. Key results include the identification and prioritization of variety indicators, evaluation of component interdependencies, and determination of component weightage, resulting in a more precise and operational design.\u0000Conclusions: The proposed model for weather radar variety enhances customer satisfaction, meets market demands, and addresses the challenges of dynamic customer needs. This methodology offers valuable insights into managing product variety and complexity, enabling designers to quickly adapt to evolving customer requirements.","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"53 32","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141804803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-03DOI: 10.18203/issn.2454-2156.intjscirep20241592
Kusumita Dutta, Siddhartha Panda
Background: To construct a heavy metal ion sensor, selectivity and sensitivity are the key important parameters to be taken care of. In our earlier work, film thickness and amount of graphene oxide (GO) content in a novel composite ANGO, synthesized from aniline, N-phenylglycine and GO was varied and sensing parameters including sensitivity, limit of detection (LOD), thermodynamic parameter which includes -∆Gad and charge transport parameter including barrier width (BW), d, of charge transfer based on Simmon’s model were evaluated and compared and an LOD of 800 ppt for Cd2+ was achieved using square wave voltammetry (SWV) withstanding interference from several ions. Methods: In this work, thermodynamic factors such as -∆Gad, ∆H, reorganization energy, partition coefficient and solvated ionic radius were used to explain the sensor performance with respect to film thickness and amount of GO. All the parameters were analyzed for different film thicknesses and amount of GO and a correlation was achieved. Finally, effect of electrochemical surface area of different polyaniline-based material on thermodynamic properties of detection process of Cd2+ was studied. Results: The variation of the thermodynamic properties for Cd2+ sensing with respect to film thickness and amount of GO were examined. Similarly, variation of thermodynamic properties for polyaniline based different sensing materials were examined. Correlation coefficients were developed from the thermodynamic parameters and the d values to explain the underlying mechanism behind improved sensor performance. Conclusions: This study can provide information on the thermodynamic properties which can be predicted from BW technique. The correlation coefficients would help in designing polyaniline based novel sensing film material with the need of lesser number of experiments.
背景：要构建重金属离子传感器，选择性和灵敏度是需要考虑的关键重要参数。在我们早期的研究中，我们改变了由苯胺、N-苯基甘氨酸和 GO 合成的新型复合 ANGO 中的薄膜厚度和氧化石墨烯 (GO) 含量，并改变了包括灵敏度、检测限 (LOD) 在内的传感参数、评估和比较了各种传感参数，包括灵敏度、检测限（LOD）、热力学参数（包括 -∆Gad ）和电荷传输参数（包括基于 Simmon 模型的电荷转移势垒宽度（BW）d），并使用方波伏安法（SWV）在抵御多种离子干扰的情况下实现了 800 ppt 的 Cd2+ 检测限。方法：在这项工作中，热力学因素（如 -ΔGad、ΔH、重组能、分配系数和溶解离子半径）被用来解释传感器性能与薄膜厚度和 GO 含量的关系。针对不同的薄膜厚度和 GO 含量对所有参数进行了分析，并得出了相关结果。最后，研究了不同聚苯胺基材料的电化学表面积对 Cd2+ 检测过程热力学性质的影响。 研究结果研究了 Cd2+ 检测的热力学性质随薄膜厚度和 GO 含量的变化。同样，还研究了基于聚苯胺的不同传感材料的热力学性质变化。根据热力学参数和 d 值建立了相关系数，以解释传感器性能提高背后的内在机制。结论：本研究可提供有关热力学性质的信息，这些信息可通过 BW 技术进行预测。 相关系数将有助于设计基于聚苯胺的新型传感薄膜材料，同时减少实验次数。
{"title":"Explanation based on thermodynamic parameters regarding effect of sensing film thickness and amount of graphene oxide on sensor performance in aniline, N-phenylglycine and graphene oxide based electrochemical heavy metal ion sensor","authors":"Kusumita Dutta, Siddhartha Panda","doi":"10.18203/issn.2454-2156.intjscirep20241592","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20241592","url":null,"abstract":"Background: To construct a heavy metal ion sensor, selectivity and sensitivity are the key important parameters to be taken care of. In our earlier work, film thickness and amount of graphene oxide (GO) content in a novel composite ANGO, synthesized from aniline, N-phenylglycine and GO was varied and sensing parameters including sensitivity, limit of detection (LOD), thermodynamic parameter which includes -∆Gad and charge transport parameter including barrier width (BW), d, of charge transfer based on Simmon’s model were evaluated and compared and an LOD of 800 ppt for Cd2+ was achieved using square wave voltammetry (SWV) withstanding interference from several ions.\u0000Methods: In this work, thermodynamic factors such as -∆Gad, ∆H, reorganization energy, partition coefficient and solvated ionic radius were used to explain the sensor performance with respect to film thickness and amount of GO. All the parameters were analyzed for different film thicknesses and amount of GO and a correlation was achieved. Finally, effect of electrochemical surface area of different polyaniline-based material on thermodynamic properties of detection process of Cd2+ was studied. \u0000Results: The variation of the thermodynamic properties for Cd2+ sensing with respect to film thickness and amount of GO were examined. Similarly, variation of thermodynamic properties for polyaniline based different sensing materials were examined. Correlation coefficients were developed from the thermodynamic parameters and the d values to explain the underlying mechanism behind improved sensor performance. \u0000Conclusions: This study can provide information on the thermodynamic properties which can be predicted from BW technique. The correlation coefficients would help in designing polyaniline based novel sensing film material with the need of lesser number of experiments.","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"111 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141272041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-23DOI: 10.18203/issn.2454-2156.intjscirep20241315
A. C. Ogunlayi, V. Ekundina, Adedapo O. Kehinde, Linus A. Enye, Adegoke O. Aremu
Background: Prostate cancer (CaP) is increasingly becoming a major health issue affecting men as cancer-related fatalities are attributable to the condition. Immunohistochemistry (IHC) diagnostic criteria can help in gene-targeted therapy and help reduce its prevalence. This study is to assess the diagnostic impact of prostate-specific antigen (PSA), P63 and BCL-2 antibodies in CaP. Method: A case-controlled retrospective study was carried out on eighty (80) prostrate tissue blocks retrieved from the pathology archive of Ekiti State university teaching hospital Ado Ekiti. IHC analysis of the selected antibodies was carried out and also stained with haematoxylin and eosin (H and E) for second opinion and confirmation. Results: The study showed that all the CaP samples had 100% positivity with varying reactivity to the IHC biomarkers; PSA had 100% positivity and MPR of 94% due to its multiple weaknesses as a biomarker p63 is a basal cells marker. Conclusions: The expressions of these antibodies were observed in the progression of CaP. Although these markers are useful in predicting the progression from benign prostatic hyperplasia (BPH) to CaP, none of them can be utilised in isolation to a conclusion. Hence, they should be used in conjunction with one another to make up for their limitations. The immunohistochemical markers are beneficial in CaP diagnosis.
背景：前列腺癌（CaP）正日益成为影响男性健康的一个主要问题，因为与癌症相关的死亡都是由前列腺癌引起的。免疫组化（IHC）诊断标准有助于基因靶向治疗，并有助于降低其发病率。本研究旨在评估前列腺特异性抗原（PSA）、P63 和 BCL-2 抗体对 CaP 的诊断影响：方法：对从埃基提州立大学阿多埃基提教学医院病理档案中提取的八（80）个前列腺组织块进行了病例对照回顾性研究。对所选抗体进行了 IHC 分析，并用血红素和伊红（H 和 E）染色，以进行第二意见和确认：研究结果表明，所有 CaP 样本的阳性率均为 100%，但对 IHC 生物标记物的反应性各不相同；PSA 的阳性率为 100%，由于其作为生物标记物的多重弱点，其 MPR 为 94%；P63 是一种基底细胞标记物：结论：在CaP的进展过程中观察到了这些抗体的表达。尽管这些标记物有助于预测良性前列腺增生症（BPH）向钙化性前列腺增生症（CaP）的进展，但它们都不能单独用于得出结论。因此，它们应结合使用，以弥补其局限性。免疫组化标记物有助于 CaP 的诊断。
{"title":"Assessing the diagnostic impact of P63, PSA and BCL-2 proteins in premalignant and malignant prostate tissues","authors":"A. C. Ogunlayi, V. Ekundina, Adedapo O. Kehinde, Linus A. Enye, Adegoke O. Aremu","doi":"10.18203/issn.2454-2156.intjscirep20241315","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20241315","url":null,"abstract":"Background: Prostate cancer (CaP) is increasingly becoming a major health issue affecting men as cancer-related fatalities are attributable to the condition. Immunohistochemistry (IHC) diagnostic criteria can help in gene-targeted therapy and help reduce its prevalence. This study is to assess the diagnostic impact of prostate-specific antigen (PSA), P63 and BCL-2 antibodies in CaP.\u0000Method: A case-controlled retrospective study was carried out on eighty (80) prostrate tissue blocks retrieved from the pathology archive of Ekiti State university teaching hospital Ado Ekiti. IHC analysis of the selected antibodies was carried out and also stained with haematoxylin and eosin (H and E) for second opinion and confirmation.\u0000Results: The study showed that all the CaP samples had 100% positivity with varying reactivity to the IHC biomarkers; PSA had 100% positivity and MPR of 94% due to its multiple weaknesses as a biomarker p63 is a basal cells marker.\u0000Conclusions: The expressions of these antibodies were observed in the progression of CaP. Although these markers are useful in predicting the progression from benign prostatic hyperplasia (BPH) to CaP, none of them can be utilised in isolation to a conclusion. Hence, they should be used in conjunction with one another to make up for their limitations. The immunohistochemical markers are beneficial in CaP diagnosis.","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"28 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141106481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-23DOI: 10.18203/issn.2454-2156.intjscirep20241320
Fatima Laique, Sameen Mukhtar, Mubashir Mohiuddin
Myasthenia gravis (MG) is an autoimmune neuromuscular disease characterized by muscle weakness due to autoantibodies targeting the neuromuscular junction (NMJ). Zilucoplan, a novel complement inhibitor, has shown promise in managing generalized MG (gMG) by blocking the terminal complement cascade. This article provides an overview of Zilucoplan's pharmacological properties, including its mechanism of action, pharmacokinetics, and pharmacodynamics. Clinical trials, including a phase 3 trial (RAISE), have demonstrated Zilucoplan's efficacy in improving muscle strength and function, as measured by the MG-ADL (MG-activities of daily life) score, compared to placebo. The safety profile of Zilucoplan is favorable, with injection-site reactions being the most common adverse event. Notably, Zilucoplan effectively inhibits both wild-type and clinical C5 variants, expanding its potential utility for patients who do not respond well to existing treatments. While further research is needed to assess its long-term safety and efficacy, Zilucoplan represents a valuable addition to the therapeutic armamentarium for managing gMG.
{"title":"Zilucoplan: a novel therapeutic approach to treat generalized myasthenia gravis","authors":"Fatima Laique, Sameen Mukhtar, Mubashir Mohiuddin","doi":"10.18203/issn.2454-2156.intjscirep20241320","DOIUrl":"https://doi.org/10.18203/issn.2454-2156.intjscirep20241320","url":null,"abstract":"Myasthenia gravis (MG) is an autoimmune neuromuscular disease characterized by muscle weakness due to autoantibodies targeting the neuromuscular junction (NMJ). Zilucoplan, a novel complement inhibitor, has shown promise in managing generalized MG (gMG) by blocking the terminal complement cascade. This article provides an overview of Zilucoplan's pharmacological properties, including its mechanism of action, pharmacokinetics, and pharmacodynamics. Clinical trials, including a phase 3 trial (RAISE), have demonstrated Zilucoplan's efficacy in improving muscle strength and function, as measured by the MG-ADL (MG-activities of daily life) score, compared to placebo. The safety profile of Zilucoplan is favorable, with injection-site reactions being the most common adverse event. Notably, Zilucoplan effectively inhibits both wild-type and clinical C5 variants, expanding its potential utility for patients who do not respond well to existing treatments. While further research is needed to assess its long-term safety and efficacy, Zilucoplan represents a valuable addition to the therapeutic armamentarium for managing gMG.","PeriodicalId":14297,"journal":{"name":"International Journal of Scientific Reports","volume":"23 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141104568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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