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Prevalence, common clinical presentations and severity patterns of post-dural puncture headache among parturients who underwent cesarean section using spinal anesthesia in western Uganda: a cross-sectional study 乌干达西部使用脊髓麻醉进行剖腹产的产妇硬膜穿刺后头痛的患病率、常见临床表现和严重程度模式:一项横断面研究
Pub Date : 2023-12-22 DOI: 10.18203/issn.2454-2156.intjscirep20233865
Theoneste Hakizimana, Osman Mohamud Jelle, M. P. S. Ishimwe
Background: Post-dural puncture headache is a complication of regional blocks that results from intentional dural puncture during spinal anesthesia and unintentional dural puncture during epidural anesthesia. The aim of the study was to determine the prevalence, common clinical presentations and severity of post-spinal puncture headache among parturients who underwent cesarean section using spinal anesthesia in western Uganda. Methods: A cross-sectional study was conducted on 249 mothers who were consecutively enrolled in their 3rd post-partum day during the period from April 2022 to July 2022 from postnatal ward of Fort portal Regional Referral Hospital. The data needed for analysis was gathered using pretested questionnaires. Data was entered into microsoft excel version 16, coded and transported into SPSS version 22 for analysis. Descriptive statistics was carried out using SPSS version 22.0.    Results: The prevalence of post-dural puncture headache among parturients who underwent cesarean section using spinal anesthesia was 81 (32.5%). Commonest clinical presentation being front/back headache 59 (72.8%), worsened with upright posture 81 (100%), coughing/sneezing 81 (100%) and improved on lying flat position 81 (100%).  The commonest form was mild one 35 (43.2%). Conclusions: This study revealed a high prevalence of post-dural puncture headache as compared to studies done in the region which mainly presented as frontal/back with the commonest form being mild.
背景:硬膜穿刺后头痛是区域阻滞的一种并发症,是脊髓麻醉时有意穿刺硬膜和硬膜外麻醉时无意穿刺硬膜造成的。本研究旨在确定乌干达西部使用脊髓麻醉进行剖宫产的产妇中脊髓穿刺后头痛的发病率、常见临床表现和严重程度。研究方法在2022年4月至2022年7月期间,对门户堡地区转诊医院产后病房连续登记的249名产后第3天的产妇进行了横断面研究。分析所需的数据是通过预先测试的问卷收集的。数据被输入到 Microsoft excel 16 版,编码后输入到 SPSS 22 版进行分析。使用 SPSS 22.0 版进行描述性统计。 结果在使用脊髓麻醉进行剖宫产的产妇中,硬膜穿刺后头痛的发病率为 81(32.5%)。最常见的临床表现为前/后头痛 59 例(72.8%),81 例(100%)在直立姿势、咳嗽/喷嚏时头痛加剧,81 例(100%)在平卧时头痛好转。 最常见的头痛形式为轻度头痛 35 例(43.2%)。结论与该地区的研究相比,本研究显示硬膜穿刺后头痛的发病率较高,主要表现为额部/背部头痛,最常见的形式为轻度头痛。
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引用次数: 0
Port site tuberculosis and retained gall stone after laparoscopic cholecystectomy 腹腔镜胆囊切除术后孔口部位结核和胆结石残留
Pub Date : 2023-11-23 DOI: 10.18203/issn.2454-2156.intjscirep20233560
Vivek Kumar, Azaz Akhtar Siddiqui, Khriethonuo Kesiezie, Mahak Goel, Arun Kumar, Jenna B. Bhattacharya, Fathima O. V.
Laparoscopic cholecystectomy is one of the most common general surgical procedures performed. Port site infection is common surgical site infection. However, tuberculosis of port sites is very uncommon. We report a case of a 36-year-old lady who was presented to our center with complaint of swelling at midclavicular port and seropurulent discharge from epigastrium port site for one month after laparoscopic cholecystectomy done outside. Patient underwent wide local excision with stone retrieval and histopathology of specimen was suggestive of chronic inflammation. Following excision patient again develop swelling at scar site and FNAC from swelling reveal feature of tuberculosis, subsequently patient was started on anti-tubercular drug therapy and follow-up after 2 months show healthy suture line with no sinus or discharge or swelling.  Port site tuberculosis in absence of tuberculosis of gall bladder and abdominal is most likely due to contamination of instrument or dressing by mycobacterium tuberculosis. Diagnosis is made by ZN staining or FNAC or biopsy. Management includes incision and drainage or debridement or wide local excision with anti-tuberculosis medication. Following standardized sterilization procedure is essential for prevention.
腹腔镜胆囊切除术是最常见的普通外科手术之一。端口部位感染是常见的手术部位感染。然而,手术孔部位的结核却非常少见。我们报告了一例 36 岁女性患者的病例,她因腹腔镜胆囊切除术后锁骨中端口肿胀和上腹部端口部位流出血清脓性分泌物一个月而到本中心就诊。患者接受了大范围局部切除术并取出结石,标本的组织病理学检查提示为慢性炎症。切除术后,患者的疤痕部位再次出现肿胀,肿胀处的 FNAC 显示出结核病的特征,随后患者开始接受抗结核药物治疗,2 个月后的随访显示缝合线健康,没有窦道、分泌物或肿胀。 在没有胆囊和腹腔结核的情况下,口腔部位结核很可能是由于器械或敷料被结核分枝杆菌污染所致。可通过 ZN 染色或 FNAC 或活检进行诊断。处理方法包括切开引流、清创或大范围局部切除,同时服用抗结核药物。遵循标准化的消毒程序是预防的关键。
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引用次数: 0
Cranium bifidum with meningocele in ruminants: a clinical insight 反刍动物伴有脑膜囊肿的双歧颅骨:临床见解
Pub Date : 2023-11-23 DOI: 10.18203/issn.2454-2156.intjscirep20233561
Abdulrauf Abdulrasheed, Ibrahim A. Suka, Yahaya B. Lawali, Mukaddas M. Ahmad, Nafiu Abdullahi, Hassan Tukur
Cranium bifidum is an incomplete closure of the skull at the suture lines, leaving a space through which the intracranial tissues can protrude. Meningocele is the herniation of the meninges containing cerebrospinal fluid through the cranium bifidum. This congenital defect is attributed to the intake of certain poisonous plants, genetic abnormalities, hereditary factors, malnutrition, bovine viral diarrhea, and others. The obvious clinical sign is a floating saccular protrusion of varied size and volume and is typically associated with cranium bifidum in the frontal or parietal region. Surgical management involves exposing the effective cranial opening and suturing the dura mater in a simple continuous pattern. Prognosis depends on the presence or absence of neurological signs; neurological signs are associated with morphological changes in brain tissue with poor prognosis.
二裂颅是指颅骨缝合线处闭合不全,留有颅内组织突出的空间。脑膜疝是指含有脑脊液的脑膜通过双侧颅骨疝出。这种先天性缺陷可归因于摄入某些有毒植物、基因异常、遗传因素、营养不良、牛病毒性腹泻等。明显的临床表现是大小和体积不一的漂浮囊状突起,通常与额叶或顶叶区的双歧颅骨有关。手术治疗包括暴露有效的颅骨开口,并以简单连续的方式缝合硬脑膜。预后取决于有无神经系统体征;神经系统体征与脑组织形态学改变有关,预后较差。
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引用次数: 0
Awareness and willingness to use oral HIV self-test and associated factor among Wollo University Health Science student in North East Ethiopia, 2023 2023 年埃塞俄比亚东北部 Wollo 大学健康科学专业学生使用口服 HIV 自我检测的意识和意愿及相关因素
Pub Date : 2023-11-23 DOI: 10.18203/issn.2454-2156.intjscirep20233558
Mullu Kassa
Background: Use of oral HIV self-test is integral part of quality improvement of HIV prevention, care and treatment.  There is no evidence related to awareness and willingness to use oral HIV self-test. The aim of the study was to assess awareness and willingness to use oral HIV self-test and associated factors. Methods: Cross-sectional study was conducted among Wollo University student. The data collection instrument was self-administered questionnaire. Simple random sampling technique was used to select the participant’s proportional to sample size. The final sample size was 373 medical students. SPSS version 26 was used to analyze data and the results were presented by using tables, Pie charts, and histograms. The study was analyzed using binary logistic regression and p value less than 0.25 was entered in Multi-variable logistic regression. Finally, p value less than 0.05 in multi-variable logistic regression was considered as statically significant. Odd ratio measured magnitude of association at 95% confidence interval.   Results: A total of 370 health science student were participated, at response rate of 98%. Prevalence of awareness and willingness among health science student toward use oral HIV self-test were 53 (14.32%) and 253 (68.38), respectively.  Factors such as participating in HIV program (AOR=3.27; CI: 1.30-8.21) and who had recent HIV risk (AOR=3.16; CI; 1.40-7.12) were more likely to had awareness toward oral HIV self-test.  Male student (AOR=1.74; CI; 1.02-2.82), who had recent HIV risk (AOR=3.36; CI: 1.40-8.08), recently tested for HIV (AOR=2.84; CI: 1.17-6.89) and who had STI (AOR=9.02; CI: 2.82-32.12) were more likely to be willingness to use oral HIV self-test in the future. Conclusions: This study showed that willingness to use HIV self-test in future was high. But awareness of HIV self-test is low. It is crucial to prioritize willingness and awareness activities particularly among sex of respondent, recent HIV risk, tested for HIV and STI client.
背景:使用口服 HIV 自我检测是提高 HIV 预防、护理和治疗质量不可或缺的一部分。 目前还没有证据表明人们对使用口服 HIV 自我检测的认识和意愿。本研究旨在评估使用口服 HIV 自我检测的意识和意愿以及相关因素。研究方法在沃洛大学学生中开展横断面研究。数据收集工具为自填式问卷。研究采用简单随机抽样技术,根据样本数量按比例抽取参与者。最终样本量为 373 名医学生。研究使用 SPSS 26 版进行数据分析,并通过表格、饼状图和柱状图展示结果。研究采用二元逻辑回归进行分析,P 值小于 0.25 的结果输入多变量逻辑回归。最后,多变量逻辑回归中小于 0.05 的 p 值被视为具有统计学意义。奇数比衡量了在 95% 置信区间内的关联程度。 研究结果共有 370 名健康科学专业学生参与,回复率为 98%。健康科学专业学生对使用口服 HIV 自我检测的认知度和意愿度分别为 53 人(14.32%)和 253 人(68.38%)。 参加艾滋病项目(AOR=3.27;CI:1.30-8.21)和最近有艾滋病风险(AOR=3.16;CI:1.40-7.12)等因素更有可能使学生对口服艾滋病病毒自我检测有认识。 男性学生(AOR=1.74;CI;1.02-2.82)、近期有 HIV 感染风险(AOR=3.36;CI:1.40-8.08)、近期接受过 HIV 检测(AOR=2.84;CI:1.17-6.89)和患有 STI(AOR=9.02;CI:2.82-32.12)的学生更有可能愿意在未来使用口服 HIV 自我检测。结论本研究表明,将来使用 HIV 自我检测的意愿很高。但对艾滋病病毒自我检测的认识却很低。尤其是在受访者的性别、最近的 HIV 风险、HIV 检测和 STI 客户中,优先开展意愿和认知活动至关重要。
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引用次数: 0
The enactment of the maternity and paternity bill 2019 of Pakistan 巴基斯坦颁布《2019 年产假和陪产假法案
Pub Date : 2023-11-23 DOI: 10.18203/issn.2454-2156.intjscirep20233562
Barka Sajid, Rabeya Farid, Muzainah Tabassum
“Parental leave” or “family leave” refers to a sanctioned duration off from work that is granted to both parents, irrespective of gender, to nurture a recently arrived offspring. This comprehensive terminology encompasses maternity, paternity, and adoption leave.  Maternity leave is an expression of honour for the awe-inspiring physical and emotional journey experienced by mothers, simultaneously intertwining with paternity and adoption leave, which shines a spotlight on indispensable contribution of fathers. In 1919, the international labor organization (ILO) was established for the sake of providing women workers their necessary maternity leave rights. As stated in convention no. 183, maternity leave should be of at least 14 weeks or above, whereas recommendation no. 191 highlighted that leave should be of at least 18 weeks. The maternity leave can be further classified into: (a) compulsory maternity leave (CML), encompassing two weeks after birth; (b) Ordinary maternity leave (OML), spanning the initial 26 weeks of maternity leave; (c) additional maternity leave (AML) accommodating the succeeding 26 weeks of leave.
"育儿假 "或 "家事假 "是指父母双方(不论性别)为抚育刚出生的孩子而休假的时间。这一综合术语包括产假、陪产假和收养假。 产假是对母亲所经历的令人敬畏的身体和情感历程的尊重,同时与陪产假和收养假相互交织,彰显了父亲不可或缺的贡献。1919 年,国际劳工组织(ILO)成立,目的是为女工提供必要的产假权利。第 183 号公约规定,产假至少应为 14 周或以上,而第 191 号建议则强调产假至少应为 18 周。产假可进一步分为:(a)强制性产假(CML),包括产后两周;(b)普通产假(OML),包括最初的 26 周产假;(c)额外产假(AML),包括随后的 26 周假期。
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引用次数: 0
Misuse of Ozempic as a drug choice for weight loss, a potential threat 滥用 Ozempic 作为减肥药物的潜在威胁
Pub Date : 2023-11-23 DOI: 10.18203/issn.2454-2156.intjscirep20233563
Uzma Aslam, Sarah Mehboob
The 387 million people around the globe are diagnosed with type 2 diabetes mellitus (T2DM). Previously used agents to treat T2DM posed adverse risks of hypoglycaemia and weight gain. Recently, Novo Nordisk, a pharmaceutical company, launched a new drug, Ozempic (Semaglutide), a glucagon-like peptide-1 receptor agonist (GLP-1 RA), which was approved by the US Food and Drug Administration on December 5, 2017. The numerous benefits of Ozempic makes it ideal for treatment of T2DM. Unfortunately, there is now an alarming shortage of Ozempic due to its misuse for weight loss.
全球有 3.87 亿人被诊断为 2 型糖尿病(T2DM)。以往用于治疗 T2DM 的药物存在低血糖和体重增加的不良风险。最近,诺和诺德制药公司推出了一种新药Ozempic(塞马鲁肽),这是一种胰高血糖素样肽-1受体激动剂(GLP-1 RA),于2017年12月5日获得美国食品药品管理局批准。Ozempic的众多优点使其成为治疗T2DM的理想药物。遗憾的是,由于被滥用于减肥,目前Ozempic的短缺情况令人担忧。
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引用次数: 0
Evaluation of diagnostic accuracy of latex agglutination test and E-test for the detection of methicillin-resistant Staphylococcus aureus 评估乳胶凝集试验和 E 试验检测耐甲氧西林金黄色葡萄球菌的诊断准确性
Pub Date : 2023-11-23 DOI: 10.18203/issn.2454-2156.intjscirep20233559
Nupur Gupta, M. Jais, Aditi Sharma, P. Shrivastava
Background: This study was undertaken to compare the phenotypic methods of latex agglutination test and e-test with polymerase chain reaction for the detection of methicillin-resistant Staphylococcus aureus. Methods: Two hundred pus samples obtained from different clinical disciplines were subjected to the latex agglutination test and minimum inhibitory concentration by e-test (Oxacillin and Vancomycin) as per the standard guidelines. The comparison was made with polymerase chain reaction as the reference test. The diagnostic accuracy of each method was reported in terms of sensitivity, specificity, positive predictive value, and negative predictive value.   Results: The sensitivity of latex agglutination test was found to be 100% whereas e-test for Oxacillin was found to be 96.67% sensitive. Higher specificity for e-test was reported (99.41%) when compared to the latex agglutination test (97.65%). Conclusions: Latex agglutination and e-tests are tests are relatively simpler, rapid, and easy-to-perform methods when compared to polymerase chain reaction. The present study reported high sensitivity and specificity values for both the tests, and therefore supports usage of the stated methods as screening tools for methicillin-resistant S. aureus. However, more multi-centric studies are recommended to precisely determine the diagnostic accuracy of these phenotypic methods.
背景:本研究旨在比较乳胶凝集试验和电子检测法与聚合酶链反应检测耐甲氧西林金黄色葡萄球菌的表型方法。检测方法按照标准指南,对从不同临床学科获得的 200 份脓液样本进行乳胶凝集试验,并通过电子测试(氧西林和万古霉素)检测最低抑菌浓度。以聚合酶链反应作为参照检验进行比较。报告了每种方法的诊断准确性,包括敏感性、特异性、阳性预测值和阴性预测值。 结果乳胶凝集试验的灵敏度为 100%,而奥沙西林电子检测的灵敏度为 96.67%。与乳胶凝集试验(97.65%)相比,电子测试的特异性更高(99.41%)。结论与聚合酶链反应相比,乳胶凝集试验和电子测试是相对简单、快速和易于操作的方法。本研究报告了这两种检测方法的高灵敏度和高特异性,因此支持使用上述方法作为耐甲氧西林金黄色葡萄球菌的筛查工具。不过,建议进行更多的多中心研究,以准确确定这些表型方法的诊断准确性。
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引用次数: 0
Theruptor Novo dressing for an infected diabetic foot ulcer: a case study Theruptor Novo敷料治疗糖尿病足溃疡感染的案例研究
Pub Date : 2023-11-09 DOI: 10.18203/issn.2454-2156.intjscirep20233532
B. Pavan
In diabetes mellitus (DM) patients with peripheral neuropathy, the diabetic foot infection (DFI) often begins with a small wound that patients may not easily detect and then progresses to a more complex wound. Diabetic foot ulcer (DFU) is estimated to occur in approximately in 25% of individuals with diabetes in India. The bacterial infection is one of the important cause for the chronicity of DFU and are accountable for the high medical costs as well as affecting patients’ quality of life significantly. Preventing DFU secondary infections is an important function of wound dressing. There are many wound dressings available for DFU, and choosing the right dressing is one of the important parameter in the management and ultimately preventing the limb amputation. In this case, the patient presented with non-healing infected DFU and we used Theruptor Novo dressings for the wound management. The Theruptor Novo dressing was efficient in exudate management and preventing secondary infection which helped in accelerated DFU healing.
在伴有周围神经病变的糖尿病(DM)患者中,糖尿病足感染(DFI)通常从患者不易发现的小伤口开始,然后发展为更复杂的伤口。据估计,印度约25%的糖尿病患者患有糖尿病足溃疡(DFU)。细菌感染是造成DFU慢性的重要原因之一,不仅造成了高昂的医疗费用,而且严重影响了患者的生活质量。预防DFU继发感染是创面敷料的重要功能。DFU有多种伤口敷料可供选择,选择合适的敷料是治疗和最终防止肢体截肢的重要参数之一。在本病例中,患者出现未愈合的感染DFU,我们使用Theruptor Novo敷料进行伤口处理。Theruptor Novo敷料在渗出液管理和防止继发感染方面有效,有助于加速DFU愈合。
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引用次数: 0
Viral conjunctivitis; a rising threat for Karachites amid Monsoon 病毒性结膜炎;季风带来的威胁越来越大
Pub Date : 2023-10-23 DOI: 10.18203/issn.2454-2156.intjscirep20233168
Uzma Aslam, Maheera Khan, Sarah Mehboob
Viral conjunctivitis (VC), now renowned as red eye, is the most recent addition to the trend of frequent viral infections amid Karachi's rainy season. Conjunctivitis affects approximately 20-40% of the population worldwide. However, the endemic rise of VC in Karachi is alarming and of great concern.
病毒性结膜炎(VC),现在被称为红眼病,是卡拉奇雨季频繁病毒感染趋势的最新成员。结膜炎影响全世界大约20-40%的人口。然而,在卡拉奇,VC的地方性上升是令人震惊和高度关注的。
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引用次数: 0
The interplay between antidiabetic medications and cancer risk 抗糖尿病药物与癌症风险之间的相互作用
Pub Date : 2023-10-23 DOI: 10.18203/issn.2454-2156.intjscirep20233169
Duaa Durrani, Muhammad Hassan, Aimen Zulfikar
Diabetes mellitus (DM) refers to a group of metabolic disorders marked by chronic hyperglycemia. Its primary cause usually involves impaired insulin secretion or impaired insulin action. Its prevalence is escalating globally. Type II DM (T2DM) is becoming more common, and it is expected to afflict 7.7% (439 million) of persons aged 20 to 79 by 2030. Diabetes appears to be linked to an increased risk of a variety of cancers, ranging from a 20 to 30% greater risk of breast or colorectal cancer to a 97% increased chance of intrahepatic cholangiocarcinoma or endometrial cancer. Shared risk factors and potential biochemical pathways have prompted investigations into the effect of antidiabetic medications (ADMs) on cancer risk. We intend to investigate the link between diabetes drugs and cancer development.
糖尿病(DM)是一组以慢性高血糖为特征的代谢紊乱。其主要原因通常包括胰岛素分泌受损或胰岛素作用受损。它的流行在全球范围内不断升级。II型糖尿病(T2DM)正变得越来越普遍,预计到2030年,20至79岁人群中有7.7%(4.39亿)患有此病。糖尿病似乎与多种癌症的风险增加有关,从患乳腺癌或结直肠癌的风险增加20%至30%到患肝内胆管癌或子宫内膜癌的风险增加97%不等。共同的危险因素和潜在的生化途径促使人们研究抗糖尿病药物(adm)对癌症风险的影响。我们打算研究糖尿病药物和癌症发展之间的联系。
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引用次数: 0
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