首页 > 最新文献

International Journal of Rehabilitation Research最新文献

英文 中文
Psychometric properties of the Obstacles and Curb tests and their discriminative ability across functional levels in ambulatory children with spastic cerebral palsy. 痉挛性脑瘫患儿障碍和抑制测试的心理测量特征及其跨功能水平的判别能力。
IF 1.7 4区 医学 Q3 REHABILITATION Pub Date : 2023-06-01 DOI: 10.1097/MRR.0000000000000575
Maha F Algabbani, Banan A Almass, Afaf A M Shaheen, Adel Alhusaini, Muneera M Almurdi, Samiah Alqabbani

The Obstacles and Curb tests are timed walking assessments that have emerged from the Spinal Cord Injury Functional Ambulation Profile and have been modified for children; however, their psychometric properties have not been adequately investigated. The aim of this research was to examine the psychometric properties of the Obstacles and Curb tests for children with cerebral palsy (CP). This cross-sectional study included 68 children aged 6-12 years; there were 34 children with CP and 34 age- and sex-matched typically developing children. Validity was examined by correlation with the 10-m Walk Test (10-MWT), Modified Time Up and Go test (mTUG), and Pediatric Balance Scale (PBS). Differences in the Obstacle and Curb test scores were calculated between children with CP and typically developing children and within different Gross Motor Function Classification System (GMFCS) levels. Children with CP completed the tests twice within a 30-min interval in the same session. The tests showed significant strong to very strong correlations with the 10-MWT, mTUG, and PBS. The within-session reliability was excellent, typically developing children were significantly faster than children with CP with high sensitivity and specificity, and the time differed significantly within the GMFCS level. Thus, the Obstacles and Curb tests can be considered valid, reliable, and sensitive walking tests for ambulatory children with CP.

障碍和抑制测试是来自脊髓损伤功能步行档案的定时步行评估,并针对儿童进行了修改;然而,他们的心理测量特性还没有得到充分的研究。本研究旨在探讨脑瘫儿童障碍与抑制测验的心理测量特性。这项横断面研究包括68名6-12岁的儿童;有34名患有CP的儿童和34名年龄和性别匹配的典型发育儿童。通过与10米步行测验(10-MWT)、修正时间上升和行走测验(mTUG)和儿童平衡量表(PBS)的相关性来检验效度。计算CP患儿和正常发育患儿以及不同大肌肉运动功能分类系统(GMFCS)水平下障碍和抑制测试分数的差异。患有CP的儿童在同一时段内每隔30分钟完成两次测试。试验显示与10-MWT、mTUG和PBS有显著的强到非常强的相关性。会话内信度极好,正常发育儿童明显快于CP患儿,具有较高的敏感性和特异性,且时间在GMFCS水平内差异显著。因此,障碍和抑制试验可以被认为是有效的,可靠的和敏感的行走试验的流动儿童CP。
{"title":"Psychometric properties of the Obstacles and Curb tests and their discriminative ability across functional levels in ambulatory children with spastic cerebral palsy.","authors":"Maha F Algabbani,&nbsp;Banan A Almass,&nbsp;Afaf A M Shaheen,&nbsp;Adel Alhusaini,&nbsp;Muneera M Almurdi,&nbsp;Samiah Alqabbani","doi":"10.1097/MRR.0000000000000575","DOIUrl":"https://doi.org/10.1097/MRR.0000000000000575","url":null,"abstract":"<p><p>The Obstacles and Curb tests are timed walking assessments that have emerged from the Spinal Cord Injury Functional Ambulation Profile and have been modified for children; however, their psychometric properties have not been adequately investigated. The aim of this research was to examine the psychometric properties of the Obstacles and Curb tests for children with cerebral palsy (CP). This cross-sectional study included 68 children aged 6-12 years; there were 34 children with CP and 34 age- and sex-matched typically developing children. Validity was examined by correlation with the 10-m Walk Test (10-MWT), Modified Time Up and Go test (mTUG), and Pediatric Balance Scale (PBS). Differences in the Obstacle and Curb test scores were calculated between children with CP and typically developing children and within different Gross Motor Function Classification System (GMFCS) levels. Children with CP completed the tests twice within a 30-min interval in the same session. The tests showed significant strong to very strong correlations with the 10-MWT, mTUG, and PBS. The within-session reliability was excellent, typically developing children were significantly faster than children with CP with high sensitivity and specificity, and the time differed significantly within the GMFCS level. Thus, the Obstacles and Curb tests can be considered valid, reliable, and sensitive walking tests for ambulatory children with CP.</p>","PeriodicalId":14301,"journal":{"name":"International Journal of Rehabilitation Research","volume":"46 2","pages":"178-186"},"PeriodicalIF":1.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/24/76/ijrr-46-178.PMC10155681.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10277940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is mirror therapy associated with progressive muscle relaxation more effective than mirror therapy alone in reducing phantom limb pain in patients with lower limb amputation? 在减轻下肢截肢患者幻肢痛方面,镜像疗法联合进行性肌肉放松是否比单独镜像疗法更有效?
IF 1.7 4区 医学 Q3 REHABILITATION Pub Date : 2023-06-01 DOI: 10.1097/MRR.0000000000000582
Stefano Brunelli, Lucia D'Auria, Andrea Stefani, Filippo Giglioni, Giorgio Mariani, Marcello Ciccarello, Maria Grazia Benedetti

Mirror therapy is a widely used treatment for phantom limb pain (PLP) relief in patients with limb loss. Less common is progressive muscle relaxation (PMR), used mostly in other medical conditions (psychological, terminal cancer pain, etc). The purpose of this study is to evaluate the efficacy of a mirror therapy preceded by PMR intervention compared to mirror therapy preceded by unguided generic relaxation-mirror therapy in patients with lower limb amputation suffering from PLP. This pilot study was a single-blind, controlled, randomized trial. Thirty lower limb amputees suffering from PLP were recruited and randomly assigned to three groups respectively undergoing a PMR-mirror therapy rehabilitative intervention, generic relaxation-mirror therapy, and conventional physiotherapy (ConvPT). Selected items from Prosthesis Evaluation Questionnaire (PEQ) and the Brief Pain Inventory (BPI) were used to test the pain features at the beginning and 1 week after 3 weeks of intervention. A decrease of about 65% was found in the rate and duration of PLP at the PEQ in PMR-mirror therapy with respect to generic relaxation-mirror therapy (about 30%) and ConvPT (about 6%). A decrease of about 90% in intensity (worst and average) of PLP in PMR-mirror therapy when compared to generic relaxation-mirror therapy (about 45%) and ConvPT (about 20%) was found at the BPI. We preliminary concluded, albeit with limitations due to the small sample of patients, that mirror therapy can improve PLP when associated with PMR. Further studies are required to confirm that PMR could be an effective technique for more successful PLP management.

镜像疗法是一种广泛应用于肢体丧失患者幻肢痛(PLP)缓解的治疗方法。不太常见的是渐进式肌肉放松(PMR),主要用于其他医疗条件(心理,晚期癌症疼痛等)。本研究的目的是评估在PMR干预前进行镜像治疗与在无指导的普通放松-镜像治疗前进行镜像治疗对下肢截肢PLP患者的疗效。这项初步研究是一项单盲、对照、随机试验。本研究招募30例下肢PLP患者,随机分为三组,分别接受pmr -镜像治疗、康复干预、常规放松-镜像治疗和常规物理治疗(ConvPT)。从假体评估问卷(PEQ)和简短疼痛量表(BPI)中选择项目用于测试干预开始时和干预3周后1周的疼痛特征。与常规松弛镜治疗(约30%)和ConvPT(约6%)相比,PMR-mirror治疗在PEQ处PLP发生率和持续时间减少约65%。在BPI处,与一般松弛-镜像治疗(约45%)和ConvPT(约20%)相比,pmr -镜像治疗的PLP强度(最差和平均)降低了约90%。我们初步得出结论,尽管由于患者样本小而存在局限性,但当与PMR相关时,镜像治疗可以改善PLP。需要进一步的研究来证实PMR可能是一种更成功的PLP管理的有效技术。
{"title":"Is mirror therapy associated with progressive muscle relaxation more effective than mirror therapy alone in reducing phantom limb pain in patients with lower limb amputation?","authors":"Stefano Brunelli,&nbsp;Lucia D'Auria,&nbsp;Andrea Stefani,&nbsp;Filippo Giglioni,&nbsp;Giorgio Mariani,&nbsp;Marcello Ciccarello,&nbsp;Maria Grazia Benedetti","doi":"10.1097/MRR.0000000000000582","DOIUrl":"https://doi.org/10.1097/MRR.0000000000000582","url":null,"abstract":"<p><p>Mirror therapy is a widely used treatment for phantom limb pain (PLP) relief in patients with limb loss. Less common is progressive muscle relaxation (PMR), used mostly in other medical conditions (psychological, terminal cancer pain, etc). The purpose of this study is to evaluate the efficacy of a mirror therapy preceded by PMR intervention compared to mirror therapy preceded by unguided generic relaxation-mirror therapy in patients with lower limb amputation suffering from PLP. This pilot study was a single-blind, controlled, randomized trial. Thirty lower limb amputees suffering from PLP were recruited and randomly assigned to three groups respectively undergoing a PMR-mirror therapy rehabilitative intervention, generic relaxation-mirror therapy, and conventional physiotherapy (ConvPT). Selected items from Prosthesis Evaluation Questionnaire (PEQ) and the Brief Pain Inventory (BPI) were used to test the pain features at the beginning and 1 week after 3 weeks of intervention. A decrease of about 65% was found in the rate and duration of PLP at the PEQ in PMR-mirror therapy with respect to generic relaxation-mirror therapy (about 30%) and ConvPT (about 6%). A decrease of about 90% in intensity (worst and average) of PLP in PMR-mirror therapy when compared to generic relaxation-mirror therapy (about 45%) and ConvPT (about 20%) was found at the BPI. We preliminary concluded, albeit with limitations due to the small sample of patients, that mirror therapy can improve PLP when associated with PMR. Further studies are required to confirm that PMR could be an effective technique for more successful PLP management.</p>","PeriodicalId":14301,"journal":{"name":"International Journal of Rehabilitation Research","volume":"46 2","pages":"193-198"},"PeriodicalIF":1.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10331090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Methods to assess the effectiveness and acceptance of information and communication technology-based assistive technology for older adults: a scoping review. 评估老年人基于信息和通信技术的辅助技术的有效性和接受度的方法:范围审查。
IF 1.7 4区 医学 Q3 REHABILITATION Pub Date : 2023-06-01 DOI: 10.1097/MRR.0000000000000571
Gabriella Tónay, Tamás Pilissy, András Tóth, Gábor Fazekas

An aging society is a growing challenge for families, social and rehabilitation service providers, and economies. Information and communication technology-based assistive technology can bolster the independence of older adults (65 years and above) and reduce their burden on caregivers. Currently, there is no unified methodology to assess the effectiveness and acceptance of these technologies. The present study undertakes a scoping review to (1) identify and characterize the methods for assessing the acceptability and usability of information and communication technology-based assistive technologies, (2) explore the advantages and disadvantages of the assessment methods, (3) determine the possibilities of combining the assessment methods and (4) define the most commonly used assessment method and set of outcome measures. The literature was searched in MEDLINE, Scopus, IEEE Cochrane and Web of Science bibliographic databases using the keywords defined by reviewers for articles in English published between 2011 and 2021. Of the 1696 matches, 31 met the inclusion criteria. It was found that a combination of different assessment methods was common in outcome measurements. Of the 31 studies, assessment methods were combined in 21 studies and multiple questionnaires were used in 11 studies. The most common technique of outcome measurement was the use of questionnaires (81%), conducting interviews (48%) and recording usability-performance measures (39%). The advantages and disadvantages of the assessment methods could not be determined in the selected studies in this scoping review.

老龄化社会对家庭、社会和康复服务提供者以及经济都是一个日益严峻的挑战。基于信息和通信技术的辅助技术可以增强老年人(65岁及以上)的独立性,并减轻他们对照顾者的负担。目前,还没有统一的方法来评估这些技术的有效性和接受程度。本研究进行了范围审查,以(1)确定和描述评估基于信息和通信技术的辅助技术的可接受性和可用性的方法,(2)探索评估方法的优缺点,(3)确定组合评估方法的可能性,(4)定义最常用的评估方法和结果测量集。在MEDLINE、Scopus、IEEE Cochrane和Web of Science书目数据库中检索2011年至2021年间发表的英文文章的评审关键词。在1696场比赛中,有31场符合入选标准。研究发现,在结果测量中,不同评估方法的组合是常见的。31项研究中,有21项研究采用了综合评价方法,11项研究采用了多重问卷。最常见的结果测量技术是使用问卷调查(81%),进行访谈(48%)和记录可用性-性能测量(39%)。评估方法的优点和缺点无法在本范围综述中选定的研究中确定。
{"title":"Methods to assess the effectiveness and acceptance of information and communication technology-based assistive technology for older adults: a scoping review.","authors":"Gabriella Tónay,&nbsp;Tamás Pilissy,&nbsp;András Tóth,&nbsp;Gábor Fazekas","doi":"10.1097/MRR.0000000000000571","DOIUrl":"https://doi.org/10.1097/MRR.0000000000000571","url":null,"abstract":"<p><p>An aging society is a growing challenge for families, social and rehabilitation service providers, and economies. Information and communication technology-based assistive technology can bolster the independence of older adults (65 years and above) and reduce their burden on caregivers. Currently, there is no unified methodology to assess the effectiveness and acceptance of these technologies. The present study undertakes a scoping review to (1) identify and characterize the methods for assessing the acceptability and usability of information and communication technology-based assistive technologies, (2) explore the advantages and disadvantages of the assessment methods, (3) determine the possibilities of combining the assessment methods and (4) define the most commonly used assessment method and set of outcome measures. The literature was searched in MEDLINE, Scopus, IEEE Cochrane and Web of Science bibliographic databases using the keywords defined by reviewers for articles in English published between 2011 and 2021. Of the 1696 matches, 31 met the inclusion criteria. It was found that a combination of different assessment methods was common in outcome measurements. Of the 31 studies, assessment methods were combined in 21 studies and multiple questionnaires were used in 11 studies. The most common technique of outcome measurement was the use of questionnaires (81%), conducting interviews (48%) and recording usability-performance measures (39%). The advantages and disadvantages of the assessment methods could not be determined in the selected studies in this scoping review.</p>","PeriodicalId":14301,"journal":{"name":"International Journal of Rehabilitation Research","volume":"46 2","pages":"113-125"},"PeriodicalIF":1.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10281610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short-term and long-term predictors of balance function in stroke patients: a 6-month follow-up study. 脑卒中患者平衡功能的短期和长期预测因素:一项6个月的随访研究
IF 1.7 4区 医学 Q3 REHABILITATION Pub Date : 2023-06-01 DOI: 10.1097/MRR.0000000000000573
Eun Young Lee, Yoonhye Na, Minjae Cho, Yu Mi Hwang, Hyun-Soo Kim, Hyonggin An, Sung-Bom Pyun

We aimed to determine early predictors of balance function (Berg Balance Scale, BBS) at 3 and 6 months after stroke using clinical, neurophysiological, and neuroimaging variables. Seventy-nine patients with hemiparesis after a stroke were included. Demographics, stroke characteristics, and clinical variables [Mini-Mental State Examination, BBS, strength in the hemiparetic hip, knee, and ankle muscles, and Fugl-Meyer Assessment Lower Extremity (FMA-LE)] were evaluated 2 weeks post-stroke, on average. Somatosensory-evoked potentials (SEP) from both tibial nerves and diffusion tensor imaging data were collected respectively within 3 weeks and 4 weeks post-onset to calculate the SEP amplitude ratio and the laterality index of fractional anisotropy of the corticospinal tract. In multiple linear regression analysis, younger age, higher FMA-LE score, and stronger hemiparetic hip extensors were independent predictors of higher BBS at 3 months post-stroke (adjusted R2  = 0.563, P  < 0.001). At 6 months post-stroke, significant predictors of higher BBS were younger age, higher FMA-LE, stronger hemiparetic hip extensors, and larger SEP amplitude ratio (adjusted R2  = 0.552, P  < 0.001), although the incremental contribution of the latter was rather small ( R2  = 0.019). We conclude that age and the initial motor impairment of the affected lower limb can inform the state of balance function at 3 and 6 months after stroke.

我们的目的是利用临床、神经生理学和神经影像学变量确定中风后3个月和6个月平衡功能(Berg balance Scale, BBS)的早期预测因子。79例中风后偏瘫患者被纳入研究。平均在卒中后2周评估人口统计学、卒中特征和临床变量[迷你精神状态检查、BBS、偏瘫髋关节、膝关节和踝关节肌肉力量以及Fugl-Meyer下肢评估(FMA-LE)]。分别于发病后3周和4周采集胫神经体感诱发电位(SEP)和弥散张量成像数据,计算SEP振幅比和皮质脊髓束各向异性分数偏侧指数。在多元线性回归分析中,年龄越小、FMA-LE评分越高、偏瘫性髋关节伸肌越强是脑卒中后3个月BBS升高的独立预测因子(校正R2 = 0.563, P
{"title":"Short-term and long-term predictors of balance function in stroke patients: a 6-month follow-up study.","authors":"Eun Young Lee,&nbsp;Yoonhye Na,&nbsp;Minjae Cho,&nbsp;Yu Mi Hwang,&nbsp;Hyun-Soo Kim,&nbsp;Hyonggin An,&nbsp;Sung-Bom Pyun","doi":"10.1097/MRR.0000000000000573","DOIUrl":"https://doi.org/10.1097/MRR.0000000000000573","url":null,"abstract":"<p><p>We aimed to determine early predictors of balance function (Berg Balance Scale, BBS) at 3 and 6 months after stroke using clinical, neurophysiological, and neuroimaging variables. Seventy-nine patients with hemiparesis after a stroke were included. Demographics, stroke characteristics, and clinical variables [Mini-Mental State Examination, BBS, strength in the hemiparetic hip, knee, and ankle muscles, and Fugl-Meyer Assessment Lower Extremity (FMA-LE)] were evaluated 2 weeks post-stroke, on average. Somatosensory-evoked potentials (SEP) from both tibial nerves and diffusion tensor imaging data were collected respectively within 3 weeks and 4 weeks post-onset to calculate the SEP amplitude ratio and the laterality index of fractional anisotropy of the corticospinal tract. In multiple linear regression analysis, younger age, higher FMA-LE score, and stronger hemiparetic hip extensors were independent predictors of higher BBS at 3 months post-stroke (adjusted R2  = 0.563, P  < 0.001). At 6 months post-stroke, significant predictors of higher BBS were younger age, higher FMA-LE, stronger hemiparetic hip extensors, and larger SEP amplitude ratio (adjusted R2  = 0.552, P  < 0.001), although the incremental contribution of the latter was rather small ( R2  = 0.019). We conclude that age and the initial motor impairment of the affected lower limb can inform the state of balance function at 3 and 6 months after stroke.</p>","PeriodicalId":14301,"journal":{"name":"International Journal of Rehabilitation Research","volume":"46 2","pages":"163-169"},"PeriodicalIF":1.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10277410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of preoperative muscle strength on postoperative walking ability in patients undergoing total knee arthroplasty. 全膝关节置换术患者术前肌力对术后行走能力的影响。
IF 1.7 4区 医学 Q3 REHABILITATION Pub Date : 2023-06-01 DOI: 10.1097/MRR.0000000000000572
Yusuke Terao, Naoki Hosaka, Yuhei Otobe, Mizue Suzuki, Iwao Kojima, Kazuya Yoshizawa, Minoru Yamada, Yasuhide Nakayama, Masahiro Abo

Although knee extensor muscle strength is strongly associated with postoperative walking ability (PWA) in patients undergoing total knee arthroplasty (TKA), few studies have considered the impact of both knee extensor and flexor muscle strength. This study aimed to determine whether operative side knee flexor and extensor muscle strength before surgery affects the PWA of patients who undergo TKA while accounting for potential covariates. This multicenter retrospective cohort study involved four university hospitals, and patients who underwent unilateral primary TKA were included. The outcome measure was the 5-m maximum walking speed test (MWS), which was completed 12 weeks postoperatively. Muscle strength was measured as the maximum isometric muscle strength required for knee flexor and extensor. Three multiple regression models with a progressively larger number of variables were developed to determine the predictors of 5-m MWS at 12 weeks post-TKA surgery. One hundred thirty-one patients who underwent TKA were enrolled in the study (men, 23.7%; mean age, 73.4 ± 6.9 years). Age, sex, operative side knee flexor muscle strength before surgery, Japanese Orthopaedic Association knee score, and preoperative walking ability were significantly associated with PWA in the final model of the multiple regression analysis ( R2  = 0.35). The current findings suggest that the operative side knee flexor muscle strength before surgery is a robust modifiable predictor of improved PWA. We believe that further validation is needed to determine the causal relationship between preoperative muscle strength and PWA.

虽然膝关节伸肌力量与全膝关节置换术(TKA)患者术后行走能力(PWA)密切相关,但很少有研究考虑膝关节伸肌和屈肌力量的影响。本研究旨在确定术前手术侧膝关节屈肌和伸肌力量是否会影响TKA患者的PWA,同时考虑潜在的协变量。这项多中心回顾性队列研究涉及四所大学医院,并纳入了单侧原发性TKA患者。结果测量为5米最大步行速度测试(MWS),于术后12周完成。肌肉力量测量为膝关节屈肌和伸肌所需的最大等距肌肉力量。开发了三个变量数量逐渐增加的多元回归模型,以确定tka手术后12周5-m MWS的预测因子。131例接受TKA的患者入组研究(男性,23.7%;平均年龄73.4±6.9岁)。在多元回归分析的最终模型中,年龄、性别、术前侧膝关节屈肌力量、日本骨科协会膝关节评分、术前行走能力与PWA有显著相关(R2 = 0.35)。目前的研究结果表明,术前手术侧膝关节屈肌力量是改善PWA的一个可靠的可修改的预测指标。我们认为术前肌力与PWA之间的因果关系需要进一步的验证。
{"title":"The impact of preoperative muscle strength on postoperative walking ability in patients undergoing total knee arthroplasty.","authors":"Yusuke Terao,&nbsp;Naoki Hosaka,&nbsp;Yuhei Otobe,&nbsp;Mizue Suzuki,&nbsp;Iwao Kojima,&nbsp;Kazuya Yoshizawa,&nbsp;Minoru Yamada,&nbsp;Yasuhide Nakayama,&nbsp;Masahiro Abo","doi":"10.1097/MRR.0000000000000572","DOIUrl":"https://doi.org/10.1097/MRR.0000000000000572","url":null,"abstract":"<p><p>Although knee extensor muscle strength is strongly associated with postoperative walking ability (PWA) in patients undergoing total knee arthroplasty (TKA), few studies have considered the impact of both knee extensor and flexor muscle strength. This study aimed to determine whether operative side knee flexor and extensor muscle strength before surgery affects the PWA of patients who undergo TKA while accounting for potential covariates. This multicenter retrospective cohort study involved four university hospitals, and patients who underwent unilateral primary TKA were included. The outcome measure was the 5-m maximum walking speed test (MWS), which was completed 12 weeks postoperatively. Muscle strength was measured as the maximum isometric muscle strength required for knee flexor and extensor. Three multiple regression models with a progressively larger number of variables were developed to determine the predictors of 5-m MWS at 12 weeks post-TKA surgery. One hundred thirty-one patients who underwent TKA were enrolled in the study (men, 23.7%; mean age, 73.4 ± 6.9 years). Age, sex, operative side knee flexor muscle strength before surgery, Japanese Orthopaedic Association knee score, and preoperative walking ability were significantly associated with PWA in the final model of the multiple regression analysis ( R2  = 0.35). The current findings suggest that the operative side knee flexor muscle strength before surgery is a robust modifiable predictor of improved PWA. We believe that further validation is needed to determine the causal relationship between preoperative muscle strength and PWA.</p>","PeriodicalId":14301,"journal":{"name":"International Journal of Rehabilitation Research","volume":"46 2","pages":"157-162"},"PeriodicalIF":1.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10277413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Randomized clinical trials of physical therapy for cerebral palsy: a review of study outcomes, methodological quality, and publication merits. 脑瘫物理治疗的随机临床试验:研究结果、方法学质量和发表价值的综述。
IF 1.7 4区 医学 Q3 REHABILITATION Pub Date : 2023-06-01 DOI: 10.1097/MRR.0000000000000576
André L F Meireles, Natália A Menegol, Giovana A Perin, Luciana S Sanada

The study aimed to examine the main characteristics of clinical trials of motor interventions in physical therapy in children with cerebral palsy (CP). The Physiotherapy Evidence Database (PEDro) was used to collect information on clinical trials regarding motor outcomes in physical therapy in children with CP. Two reviewers independently screened, selected the studies, and extracted data. The characteristics extracted were CP subtype; age group; gross motor function and manual motor ability; methodological quality; open access status; 2020 journal impact factor, Consolidated Standards of Reporting Trials (CONSORT) endorsement; primary outcome; intervention adopted, and assessment instruments. The search strategy resulted in 313 articles from 120 different journals. Most of the clinical trials included participants with spastic bilateral subtype, aged between 6 and 12 years old, and with fewer limitations in gross and manual motor abilities. The most used primary outcomes covering the International Classification of Functioning, Disability and Health (ICF) domain of activity were gross motor function (18.8%) and upper limb and hand function (16.3%), with the Gross Motor Function Measurement being the most frequently used instrument (19.8%). Articles with better scores on the PEDro scale were published in journals with a higher impact factor, and higher rates of CONSORT endorsement, and most were not open access. Clinical trials investigating motor interventions used in physical therapy for children with CP tend to focus on patients with milder gross and manual motor function impairments and often explore the body function domain of the ICF. Furthermore, these studies have moderate methodological quality, and a substantial proportion of them fail to follow adequate reporting and methodological recommendations.

本研究旨在探讨运动干预在脑瘫(CP)儿童物理治疗中的临床试验的主要特点。物理治疗证据数据库(PEDro)用于收集关于物理治疗CP儿童运动结局的临床试验信息。两位评论者独立筛选、选择研究并提取数据。提取的特征为CP亚型;年龄段;粗大运动功能和手工运动能力;方法学质量;开放获取状态;2020期刊影响因子,综合报告试验标准(CONSORT)认可;主要结果;采取的干预措施和评估工具。这种搜索策略产生了来自120种不同期刊的313篇文章。大多数临床试验包括6至12岁的痉挛双侧亚型参与者,他们在粗大和手动运动能力方面的限制较少。覆盖国际功能、残疾和健康分类(ICF)活动域的最常用的主要结局是大运动功能(18.8%)和上肢和手功能(16.3%),大运动功能测量是最常用的工具(19.8%)。在PEDro量表上得分较高的文章发表在影响因子较高、CONSORT认可率较高的期刊上,而且大多数都不是开放获取的。研究运动干预用于小儿脑瘫物理治疗的临床试验往往侧重于轻度大、手运动功能障碍患者,并经常探索ICF的身体功能域。此外,这些研究的方法学质量一般,其中很大一部分没有遵循适当的报告和方法学建议。
{"title":"Randomized clinical trials of physical therapy for cerebral palsy: a review of study outcomes, methodological quality, and publication merits.","authors":"André L F Meireles,&nbsp;Natália A Menegol,&nbsp;Giovana A Perin,&nbsp;Luciana S Sanada","doi":"10.1097/MRR.0000000000000576","DOIUrl":"https://doi.org/10.1097/MRR.0000000000000576","url":null,"abstract":"<p><p>The study aimed to examine the main characteristics of clinical trials of motor interventions in physical therapy in children with cerebral palsy (CP). The Physiotherapy Evidence Database (PEDro) was used to collect information on clinical trials regarding motor outcomes in physical therapy in children with CP. Two reviewers independently screened, selected the studies, and extracted data. The characteristics extracted were CP subtype; age group; gross motor function and manual motor ability; methodological quality; open access status; 2020 journal impact factor, Consolidated Standards of Reporting Trials (CONSORT) endorsement; primary outcome; intervention adopted, and assessment instruments. The search strategy resulted in 313 articles from 120 different journals. Most of the clinical trials included participants with spastic bilateral subtype, aged between 6 and 12 years old, and with fewer limitations in gross and manual motor abilities. The most used primary outcomes covering the International Classification of Functioning, Disability and Health (ICF) domain of activity were gross motor function (18.8%) and upper limb and hand function (16.3%), with the Gross Motor Function Measurement being the most frequently used instrument (19.8%). Articles with better scores on the PEDro scale were published in journals with a higher impact factor, and higher rates of CONSORT endorsement, and most were not open access. Clinical trials investigating motor interventions used in physical therapy for children with CP tend to focus on patients with milder gross and manual motor function impairments and often explore the body function domain of the ICF. Furthermore, these studies have moderate methodological quality, and a substantial proportion of them fail to follow adequate reporting and methodological recommendations.</p>","PeriodicalId":14301,"journal":{"name":"International Journal of Rehabilitation Research","volume":"46 2","pages":"126-132"},"PeriodicalIF":1.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10277939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A simple smartphone-aided program to support meaningful occupation in people with severe neuro-motor and speech disabilities. 一个简单的智能手机辅助程序,支持有严重神经运动和语言障碍的人有意义的职业。
IF 1.7 4区 医学 Q3 REHABILITATION Pub Date : 2023-06-01 DOI: 10.1097/MRR.0000000000000583
Fiora D'Amico, Giulio E Lancioni, Flavio De Marinis, Fabiana Abbinante, Paolo Taurisano, Chiara Abbatantuono, Gloria Alberti

We assessed a simple smartphone-aided program to help three participants with severe neuro-motor and speech disabilities access preferred songs, call or send messages to distant partners, and call the caregiver. The program relied on the use of a smartphone, five cards with identification tags, and a mini speaker. The participants could select one of the cards (engagement options) by touching it with the smartphone. Using the program, all participants managed to access songs, reach partners, and call the caregiver independently and engaged in the related forms of leisure and communication/interaction throughout the 10-min sessions available. The results suggest that the program might be a valuable aid for people with severe neuro-motor and speech disabilities.

我们评估了一个简单的智能手机辅助程序,帮助三名患有严重神经运动和语言障碍的参与者收听喜欢的歌曲,给远方的伴侣打电话或发信息,并打电话给照顾者。该程序依赖于使用智能手机,五张带有识别标签的卡片和一个迷你扬声器。参与者可以用智能手机触摸其中一张卡片(参与选项)。使用该程序,所有参与者都能够独立地访问歌曲,联系伴侣,并在10分钟的可用会话中参与相关形式的休闲和交流/互动。结果表明,该程序可能对有严重神经运动和语言障碍的人有价值的帮助。
{"title":"A simple smartphone-aided program to support meaningful occupation in people with severe neuro-motor and speech disabilities.","authors":"Fiora D'Amico,&nbsp;Giulio E Lancioni,&nbsp;Flavio De Marinis,&nbsp;Fabiana Abbinante,&nbsp;Paolo Taurisano,&nbsp;Chiara Abbatantuono,&nbsp;Gloria Alberti","doi":"10.1097/MRR.0000000000000583","DOIUrl":"https://doi.org/10.1097/MRR.0000000000000583","url":null,"abstract":"<p><p>We assessed a simple smartphone-aided program to help three participants with severe neuro-motor and speech disabilities access preferred songs, call or send messages to distant partners, and call the caregiver. The program relied on the use of a smartphone, five cards with identification tags, and a mini speaker. The participants could select one of the cards (engagement options) by touching it with the smartphone. Using the program, all participants managed to access songs, reach partners, and call the caregiver independently and engaged in the related forms of leisure and communication/interaction throughout the 10-min sessions available. The results suggest that the program might be a valuable aid for people with severe neuro-motor and speech disabilities.</p>","PeriodicalId":14301,"journal":{"name":"International Journal of Rehabilitation Research","volume":"46 2","pages":"205-208"},"PeriodicalIF":1.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10282077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stroke impairment, balance, and cognitive status on admission predict walking independence up to 90 days post-stroke but their contributions change over time. 卒中损伤、平衡和入院时的认知状态可预测卒中后90天内的行走独立性,但其作用随时间而变化。
IF 1.7 4区 医学 Q3 REHABILITATION Pub Date : 2023-03-01 DOI: 10.1097/MRR.0000000000000561
Kenta Hiratsuka, Takamichi Tamiya, Shinji Matsuoka, Kazushi Kimura

This study aimed to identify predictors of gait independence in three successive patient cohorts that received inpatient rehabilitation for at least 30 days, 60 days, or 90 days post-stroke. A total of 26 independent variables were collected within 3 days of stroke onset, including basic information (age, sex, stroke type), sensorimotor function (Stroke Impairment Assessment Set), gait function, balance function, and cognitive function. The dependent variable was walking independence (without assistance from another person) at 30, 60, or 90 days post-stroke. A decision tree was developed for predicting gait independence at each assessment time point. The predictors of walking independence differed among the cohorts that received inpatient rehabilitation for at least 30, 60, and 90 days post-stroke. Specifically, the Short Form Berg Balance Scale score was in the higher layer and was a strong predictor of gait at all time points. The cognitive Functional Independence Measure progressed to the higher layer at later time points. The lower extremity motor function was an additional predictor in the 30-day cohort. For later cohorts, the predictive value of balance and cognitive function declined whereas the contribution of the paralyzed grip strength and trunk function increased. These results suggest that sensorimotor and cognitive function within 3 days of stroke can predict walking independence between 1 and 3 months post-stroke; however, the prognostic value of predictors varies among the patients who receive inpatient rehabilitation for shorter versus longer time.

本研究旨在确定三个连续患者队列的步态独立性预测因素,这些患者在中风后接受住院康复至少30天,60天或90天。在脑卒中发生3天内共收集26个自变量,包括基本信息(年龄、性别、脑卒中类型)、感觉运动功能(脑卒中损害评估集)、步态功能、平衡功能、认知功能。因变量是卒中后30,60或90天的行走独立性(无需他人帮助)。建立决策树用于预测每个评估时间点的步态独立性。卒中后住院康复至少30天、60天和90天的队列中,行走独立性的预测因子存在差异。具体来说,短形式伯格平衡量表评分处于较高的层次,是所有时间点步态的有力预测指标。认知功能独立性测试在较晚的时间点向更高的层次发展。在30天的队列中,下肢运动功能是一个额外的预测因子。在后来的队列中,平衡和认知功能的预测价值下降,而瘫痪的握力和躯干功能的贡献增加。这些结果表明,卒中后3天内的感觉运动和认知功能可以预测卒中后1至3个月的行走独立性;然而,预测因子的预后价值在住院康复时间较短和较长患者之间存在差异。
{"title":"Stroke impairment, balance, and cognitive status on admission predict walking independence up to 90 days post-stroke but their contributions change over time.","authors":"Kenta Hiratsuka,&nbsp;Takamichi Tamiya,&nbsp;Shinji Matsuoka,&nbsp;Kazushi Kimura","doi":"10.1097/MRR.0000000000000561","DOIUrl":"https://doi.org/10.1097/MRR.0000000000000561","url":null,"abstract":"<p><p>This study aimed to identify predictors of gait independence in three successive patient cohorts that received inpatient rehabilitation for at least 30 days, 60 days, or 90 days post-stroke. A total of 26 independent variables were collected within 3 days of stroke onset, including basic information (age, sex, stroke type), sensorimotor function (Stroke Impairment Assessment Set), gait function, balance function, and cognitive function. The dependent variable was walking independence (without assistance from another person) at 30, 60, or 90 days post-stroke. A decision tree was developed for predicting gait independence at each assessment time point. The predictors of walking independence differed among the cohorts that received inpatient rehabilitation for at least 30, 60, and 90 days post-stroke. Specifically, the Short Form Berg Balance Scale score was in the higher layer and was a strong predictor of gait at all time points. The cognitive Functional Independence Measure progressed to the higher layer at later time points. The lower extremity motor function was an additional predictor in the 30-day cohort. For later cohorts, the predictive value of balance and cognitive function declined whereas the contribution of the paralyzed grip strength and trunk function increased. These results suggest that sensorimotor and cognitive function within 3 days of stroke can predict walking independence between 1 and 3 months post-stroke; however, the prognostic value of predictors varies among the patients who receive inpatient rehabilitation for shorter versus longer time.</p>","PeriodicalId":14301,"journal":{"name":"International Journal of Rehabilitation Research","volume":"46 1","pages":"61-69"},"PeriodicalIF":1.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10680335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing individual-level measurement precision of the Short Physical Performance Battery using the test information function. 使用测试信息功能评估短物理性能电池的个人水平测量精度。
IF 1.7 4区 医学 Q3 REHABILITATION Pub Date : 2023-03-01 DOI: 10.1097/MRR.0000000000000557
Franco Franchignoni, Andrea Giordano, Linda Rinaldo, Murat Kara, Levent Özçakar

The Short Physical Performance Battery (SPPB) is a commonly used tool to assess lower extremity function, composed of three assessments (standing balance, gait speed, and chair stand). While its validity for group-level decisions has been positively demonstrated, the measurement precision at the individual level needs more clarification. We aimed to examine the SPPB's psychometric characteristics including its conditional measurement precision with Rasch methods in a sample of elderly patients admitted to cardiac rehabilitation. We analyzed prospectively collected SPPB data from 637 patients aged ≥75 years, admitted to our cardiac rehabilitation department (January 2018-July 2019). After classical Rasch analysis, we calculated the test information function to examine the measurement precision of the SPPB along the score continuum. The mean SPPB score was 6.3 points (SD 3.4) (potential range 0-12). Our results confirmed the SPPB unidimensionality (variance attributable to the main factor: 84.8%), appropriate functioning of rating scale categories, internal construct validity (infit and outfit mean-square statistics: 0.90-1.09), and no item local dependence (residual correlations <0.2). However, the measurement precision at the individual level was quite limited (SE >  0.94 logits): the confidence intervals for true scores were, at best, about one-third of the score range (four points). This limited measurement precision increases the risk of inappropriate clinical decisions about individuals in diagnostic classification or change assessment. Therefore, further research of high methodological quality is warranted on this point. Moreover, a clearer distinction between group-level vs. individual-level indicators of change is necessary.

短物理性能测试(SPPB)是一种常用的评估下肢功能的工具,由三个评估组成(站立平衡、步态速度和椅子站立)。虽然它对群体层面决策的有效性已经得到了积极的证明,但在个人层面的测量精度需要更多的澄清。我们的目的是检查SPPB的心理测量特征,包括它的条件测量精度Rasch方法在入院的老年患者心脏康复样本。我们对2018年1月至2019年7月在心脏康复科住院的637例年龄≥75岁的患者的SPPB数据进行前瞻性分析。通过经典的Rasch分析,我们计算了测试信息函数来检验SPPB在分数连续体上的测量精度。SPPB平均评分为6.3分(SD 3.4)(电位范围0-12)。我们的结果证实了SPPB的单维性(主因子方差:84.8%)、评定量表类别的适当功能、内部结构效度(infit和outfit均方统计量:0.90-1.09)和无项目局部依赖性(残差相关0.94 logits):真实得分的置信区间最多约为得分范围的三分之一(4分)。这种有限的测量精度增加了在诊断分类或变化评估中对个体进行不适当临床决策的风险。因此,在这一点上,有必要进行高质量的进一步研究。此外,有必要更清楚地区分群体水平和个人水平的变化指标。
{"title":"Assessing individual-level measurement precision of the Short Physical Performance Battery using the test information function.","authors":"Franco Franchignoni,&nbsp;Andrea Giordano,&nbsp;Linda Rinaldo,&nbsp;Murat Kara,&nbsp;Levent Özçakar","doi":"10.1097/MRR.0000000000000557","DOIUrl":"https://doi.org/10.1097/MRR.0000000000000557","url":null,"abstract":"<p><p>The Short Physical Performance Battery (SPPB) is a commonly used tool to assess lower extremity function, composed of three assessments (standing balance, gait speed, and chair stand). While its validity for group-level decisions has been positively demonstrated, the measurement precision at the individual level needs more clarification. We aimed to examine the SPPB's psychometric characteristics including its conditional measurement precision with Rasch methods in a sample of elderly patients admitted to cardiac rehabilitation. We analyzed prospectively collected SPPB data from 637 patients aged ≥75 years, admitted to our cardiac rehabilitation department (January 2018-July 2019). After classical Rasch analysis, we calculated the test information function to examine the measurement precision of the SPPB along the score continuum. The mean SPPB score was 6.3 points (SD 3.4) (potential range 0-12). Our results confirmed the SPPB unidimensionality (variance attributable to the main factor: 84.8%), appropriate functioning of rating scale categories, internal construct validity (infit and outfit mean-square statistics: 0.90-1.09), and no item local dependence (residual correlations <0.2). However, the measurement precision at the individual level was quite limited (SE >  0.94 logits): the confidence intervals for true scores were, at best, about one-third of the score range (four points). This limited measurement precision increases the risk of inappropriate clinical decisions about individuals in diagnostic classification or change assessment. Therefore, further research of high methodological quality is warranted on this point. Moreover, a clearer distinction between group-level vs. individual-level indicators of change is necessary.</p>","PeriodicalId":14301,"journal":{"name":"International Journal of Rehabilitation Research","volume":"46 1","pages":"46-52"},"PeriodicalIF":1.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10679431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Association of obesity and cardiovascular disease and progress in pharmacotherapy: what is next for obesity? 肥胖与心血管疾病的关系及药物治疗进展:肥胖的下一步是什么?
IF 1.7 4区 医学 Q3 REHABILITATION Pub Date : 2023-03-01 DOI: 10.1097/MRR.0000000000000565
Manthar Ali Mallah, Tahmina Soomro, Sobia Noreen, Mukhtiar Ali, Akriti Kafle, Nafeesa Khatoon, Muhammad Naveed

Obesity has recently emerged as one of the most severe health concerns. Obesity is a key autonomous risk factor for heart failure and contributes to cardiovascular disease (CVD) risk factors such as hypertension, type 2 diabetes, and metabolic abnormalities. Obesity is caused by a metabolic imbalance, which occurs when calories burnt are fewer than the number of calories consumed. There are several pathways accountable for the adverse impacts of obesity on the cardiovascular system. Inflammatory cell infiltration develops in the adipose tissue, the pancreas, and other issues similar to the progression of obesity. Inflammation is triggered by immune cells that invade dysfunctional adipose tissue. The atherosclerotic inflammation phase, related to obesity, induces coronary calcification. Obesity is linked to elevated levels of leptin and high blood pressure. Leptin causes systemic vasoconstriction, sodium retention, and increased blood pressure by influencing the synthesis of nitric oxide and activating the sympathetic nervous system. Obesity is a well-known risk factor for CVD and is one of the leading causes of the greater risk of diseases, including dyslipidemia, hypertension, depression, metabolic syndrome, atrial fibrillation, and heart failure in adults and children. When used with dietary improvements, antiobesity drugs improve the probability of experiencing clinically healthy (5%) weight loss. This review aimed to address the consequences of obesity on cardiac structure and function, risk factors, the impact of the obesity paradox, pharmacological treatment strategies for managing and recommended exercise and diet.

肥胖最近已成为最严重的健康问题之一。肥胖是心力衰竭的一个关键的自主危险因素,并有助于心血管疾病(CVD)的危险因素,如高血压、2型糖尿病和代谢异常。肥胖是由代谢不平衡引起的,当燃烧的卡路里少于摄入的卡路里时就会发生这种情况。肥胖对心血管系统的不利影响有几种途径。炎症细胞浸润在脂肪组织、胰腺和其他类似于肥胖进展的部位。炎症是由免疫细胞侵入功能失调的脂肪组织引发的。与肥胖相关的动脉粥样硬化炎症期可诱发冠状动脉钙化。肥胖与瘦素水平升高和高血压有关。瘦素通过影响一氧化氮的合成和激活交感神经系统引起全身血管收缩、钠潴留和血压升高。肥胖是心血管疾病的一个众所周知的危险因素,也是导致成人和儿童血脂异常、高血压、抑郁症、代谢综合征、心房颤动和心力衰竭等疾病风险增加的主要原因之一。当与饮食改善一起使用时,抗肥胖药物可提高临床健康体重减轻(5%)的可能性。本综述旨在探讨肥胖对心脏结构和功能的影响、危险因素、肥胖悖论的影响、控制肥胖的药物治疗策略以及推荐的运动和饮食。
{"title":"Association of obesity and cardiovascular disease and progress in pharmacotherapy: what is next for obesity?","authors":"Manthar Ali Mallah,&nbsp;Tahmina Soomro,&nbsp;Sobia Noreen,&nbsp;Mukhtiar Ali,&nbsp;Akriti Kafle,&nbsp;Nafeesa Khatoon,&nbsp;Muhammad Naveed","doi":"10.1097/MRR.0000000000000565","DOIUrl":"https://doi.org/10.1097/MRR.0000000000000565","url":null,"abstract":"<p><p>Obesity has recently emerged as one of the most severe health concerns. Obesity is a key autonomous risk factor for heart failure and contributes to cardiovascular disease (CVD) risk factors such as hypertension, type 2 diabetes, and metabolic abnormalities. Obesity is caused by a metabolic imbalance, which occurs when calories burnt are fewer than the number of calories consumed. There are several pathways accountable for the adverse impacts of obesity on the cardiovascular system. Inflammatory cell infiltration develops in the adipose tissue, the pancreas, and other issues similar to the progression of obesity. Inflammation is triggered by immune cells that invade dysfunctional adipose tissue. The atherosclerotic inflammation phase, related to obesity, induces coronary calcification. Obesity is linked to elevated levels of leptin and high blood pressure. Leptin causes systemic vasoconstriction, sodium retention, and increased blood pressure by influencing the synthesis of nitric oxide and activating the sympathetic nervous system. Obesity is a well-known risk factor for CVD and is one of the leading causes of the greater risk of diseases, including dyslipidemia, hypertension, depression, metabolic syndrome, atrial fibrillation, and heart failure in adults and children. When used with dietary improvements, antiobesity drugs improve the probability of experiencing clinically healthy (5%) weight loss. This review aimed to address the consequences of obesity on cardiac structure and function, risk factors, the impact of the obesity paradox, pharmacological treatment strategies for managing and recommended exercise and diet.</p>","PeriodicalId":14301,"journal":{"name":"International Journal of Rehabilitation Research","volume":"46 1","pages":"14-25"},"PeriodicalIF":1.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10680329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
International Journal of Rehabilitation Research
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1