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2015 19th National Biomedical Engineering Meeting (BIYOMUT)最新文献

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Image processing based vascular network analysis 基于图像处理的血管网络分析
Pub Date : 2015-11-01 DOI: 10.1109/BIYOMUT.2015.7369453
Sercan Erbakan, I. Bakar, E. Z. Engin, Kubra Seker, Ibrahim Akkaya, M. Engin
Uncontrolled new blood vessel formation (angiogenesis) is really important step for the growth and metastasis of cancer cells. Nowadays, drugs which inhibit new vessel growth have been developed for cancer treatment. In cancer treatment management, it is vital to know which extend the vascularity reaches in order to guide the treatment. Vascular imaging devices and methods of treatment are available in clinical applications. However, many of them are invasively, non-portable and expensive systems. On the other hand, early diagnosis of skin and breast cancers gradually increased, which greatly increases the rate of survival. Hence, the need for a portable, cheap and non-invasive system plays an important role for the monitoring of early diagnostic conditions and/or the structure of a diagnosed tumor. To detect the new blood vessel formation, analysis of vessel complexity and width can be used on the recorded images by the systems. In this study; artificial vascular networks are used to determine the image processing techniques for using these analyses.
不受控制的新血管形成(血管生成)是癌细胞生长和转移的重要步骤。如今,抑制新血管生长的药物已经被开发出来用于癌症治疗。在癌症治疗管理中,了解血管的延伸范围是至关重要的,以便指导治疗。血管成像设备和治疗方法可在临床应用。然而,它们中的许多都是侵入性的、不可移植的和昂贵的系统。另一方面,皮肤癌和乳腺癌的早期诊断逐渐增加,这大大提高了生存率。因此,对便携式、廉价和非侵入性系统的需求对于监测早期诊断条件和/或诊断肿瘤的结构起着重要作用。为了检测新血管的形成,系统可以对记录的图像进行血管复杂性和血管宽度分析。在本研究中;人工血管网络用于确定使用这些分析的图像处理技术。
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引用次数: 0
Automatic computer-aided detection of Multiple Sclerosis (MS) lesions on MR images 磁共振图像上多发性硬化症(MS)病变的自动计算机辅助检测
Pub Date : 2015-11-01 DOI: 10.1109/BIYOMUT.2015.7369443
Z. Ekgi, Muhammed Emin Ozean, A. Aralaşmak, E. Dandıl, M. Çakiroglu
Multiple Sclerosis (MS) is a central nervous system (CNS) disorders resulting from damage to the myelin sheath which helps to ensure the transmission of messages between the brain and spinal cord. MS lesions occur in patients with damage to the myelin sheath. Progression of MS lesions is important for examining the disease. MS lesions often Magnetic Resonance Imaging (MRI) is determined and planned the follow-up / treatment processes. In this study, a computer-aided detection system has been proposed to diagnose MS lesions on FLAIR MR images. The proposed system uses Fuzzy-C Means (FCM) and morphological operations for segmentation of MS lesions. In the study, the lesions detected by aid of physicians and the lesions detected by means of the proposed system have been compared according to the Jaccard index. Similarity rate in the comparison operation on a total of 90 MR images is calculated as 91.2%. Consequently, it has been shown that the proposed system successfully detected the MS lesions.
多发性硬化症(MS)是一种中枢神经系统(CNS)疾病,由髓鞘损伤引起,髓鞘有助于确保大脑和脊髓之间的信息传递。多发性硬化症病变发生在髓鞘受损的患者身上。多发性硬化症病变的进展对检查疾病很重要。多发性硬化症病变通常由磁共振成像(MRI)确定并计划随访/治疗过程。在本研究中,提出了一种计算机辅助检测系统来诊断FLAIR MR图像上的MS病变。该系统使用模糊c均值(FCM)和形态学操作对MS病变进行分割。在本研究中,根据Jaccard指数对医生辅助检测到的病变和采用该系统检测到的病变进行了比较。在共90张MR图像的比较操作中,计算出相似率为91.2%。因此,它已被证明,提出的系统成功地检测MS病变。
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引用次数: 1
Observation Of stress distribution On a 3D wrist model after scaphoid fracture 舟状骨骨折后三维腕关节模型应力分布的观察
Pub Date : 2015-11-01 DOI: 10.1109/BIYOMUT.2015.7369448
Eser Pala, H. Oflaz
Scaphoid bone fractures are very often among carpus fractures. However, sacphoid fractures are diagnozed tardily. So, this lateness changes the treatment prognosis. Kirschner wires are mostly preffered because of its easiness of use as scaphoid fracture detection materials. Aim of this study is analyzing the stress distrubution of wrist and the change of total deformation before and after scaphoid fractures and also after the application of Kirschner wire. Segmentation process was done on CT images of wrist and 3D “stl” model was obtained and converted to solid model and finite element analysis were performed to realise this study. Metacarpal, carpaş, radius and ulna bones were linked as linear arc before the analysis. Afterwards, total stress distrubution and deformation were analyzed according to applied forces on metacarpal bones of fixed radius and ulna bones. By regarding the finite element analysis results, von-Misses stress distrubution were found 240,62 MPa before scaphoid fracture, 338,27 MPa after scaphoid fracture and 2678,1 MPa with after Kirschner wire application. Consequently, stress accumulation were observed on both scaphoid bone and Kirschner wire after scaphoid fracture. After this study, different fixation methods should be compared under same boundry conditions and then the most suitable fixation method may be determined. Moreover, it is encouraging that the most suitable personel implant designs may be done by using engineering approaches mentioned in this study.
舟状骨骨折是腕骨骨折中最常见的骨折。然而,骶骨骨折诊断迟缓。所以,这种延迟改变了治疗预后。克氏针作为舟状骨骨折检测材料,使用方便,是首选。本研究的目的是分析舟状骨骨折前后及应用克氏针后腕关节的应力分布及总变形的变化。对腕部CT图像进行分割处理,获得三维“stl”模型,并将其转换为实体模型,进行有限元分析,实现本研究。分析前,掌骨、腕骨、桡骨和尺骨呈直线弧线连接。然后根据固定桡骨和尺骨的掌骨受力情况分析总应力分布和变形情况。通过有限元分析结果,舟状骨断裂前的非遗漏应力分布为240、62 MPa,舟状骨断裂后的非遗漏应力分布为338、27 MPa,施克氏针后的非遗漏应力分布为2678、1 MPa。因此,在舟骨骨折后,在舟骨和克氏针上均观察到应力积累。通过本研究,在相同的边界条件下,比较不同的固定方法,从而确定最合适的固定方法。此外,令人鼓舞的是,最合适的个人种植体设计可以通过使用本研究中提到的工程方法来完成。
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引用次数: 0
Determination of glucose concentration by pulsed laser based photoacoustic method 脉冲激光光声法测定葡萄糖浓度
Pub Date : 2015-11-01 DOI: 10.1109/BIYOMUT.2015.7369464
C. Togay, Samet Yilmaz, Ibrahim Akkaya, Anıl Işıkhan, E. Z. Engin, M. Engin
The aim of this study is to asist in the measurement of blood glucose concentration in an in-vitro medium by using the photoacoustic method. The tissue was mimicked with gel phantoms and different glucose concentrations were added. The sample which was in the setup was illuminated by a pulsed based laser. The acoustic vibrations that arose in the phantom medium were detected via electret microphone and processed with an electronical circuit and then recorded. When the results were evaluated, there was a correlation with glucose concentration proportions and with the photoacoustic signal amplitudes.
本研究的目的是利用光声方法辅助体外培养基中血糖浓度的测量。用凝胶模型模拟组织,并加入不同浓度的葡萄糖。在装置中的样品被脉冲激光照射。通过驻极体麦克风检测到幽灵介质中产生的声音振动,并用电子电路进行处理,然后记录下来。当结果被评估时,有葡萄糖浓度比例和光声信号振幅的相关性。
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引用次数: 1
Evoked potential in response to familiar and unfamiliar face Stimuli and their time-location analysis 熟悉与陌生面孔刺激的诱发电位及其时间-位置分析
Pub Date : 2015-11-01 DOI: 10.1109/BIYOMUT.2015.7369457
Abdurrahman Ozbeyaz, S. Arıca
Evoked potentials (EP) occur against a specific stimulus as a response in EEG signal. The objective of this study is to determine time and location where the evoked potentials obtained in a familiar/unfamiliar face recognition experiments, are most distant. EEG signals have been acquired from 10 subjects in different sessions and the time and position where ERP signals obtained in response to familiar and unfamiliar face stimuli have been analyzed using statistical methods. This study can be considered as a first step for an EEG signal classification problem of an familiar and unfamiliar face recognition experiment. Such a classification both can help to the experts in the diagnosis of some diseases in the visual memory areas of the brain and can contribute to the identification of suspects in criminal inspections.
诱发电位(EP)是脑电信号中针对特定刺激产生的一种反应。本研究的目的是确定在熟悉/不熟悉的人脸识别实验中获得的诱发电位的时间和地点是最遥远的。采用统计学方法对10名被试在不同时段获得的脑电信号进行分析,并对熟悉和陌生面孔刺激下获得的ERP信号的时间和位置进行分析。本研究可作为熟悉与陌生人脸识别实验中脑电信号分类问题的第一步。这种分类既可以帮助专家诊断大脑视觉记忆区域的某些疾病,也可以有助于刑事检查中嫌疑人的识别。
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引用次数: 0
Biomechanical comparison of stability of resorbable plate-screw fixation systems in different configurations after sagittal split ramus osteotomy 矢状分叉支截骨术后不同构型可吸收钢板-螺钉固定系统稳定性的生物力学比较
Pub Date : 2015-11-01 DOI: 10.1109/BIYOMUT.2015.7369463
M. Ulu, S. Kelebek, Serkan Dikici, H. Akçay, H. Oflaz
Sagittal split ramus osteotomy (SSRO) has been successfully and widely applied in the treatment of specific dentofacial deformities. Many techniques and materials have been used by surgeons like wire osteosynthesis miniplates and screws used for fixation and stabilization after SSRO. While most post surgical complications related to titanium mini plates and/or screws requring second surgery to remove and disadvantages of metalic fixations have been developed and employed in studies focusing on evaluation of resorbable metarials in mandibular sagittal split osteotomy fixation and stabilization. Recently more surgeons have prefered to use resorbable materials in upregulation, stil the reliability of resorbable materials at different jaw sites after osteotomies or fractures remains a matter of concern for surgeons which limits to use resorbable materials systems by such surgeons. In literature, number of studies about analysis and comparison of clinical results of sagittal split ramus osteotomy performed with the use of resorbable plate/screw systems have not been satisfactory enough yet. In this study, 8 polyurethane synthetic mandibular replicas (Synbone 8598, Switzerland) were used and totally 2 groups were comprised. Afer employed SSRO on samples, fixations of bone segments were achieved using resorbable plate/screw systems (Inion CPS sistem, Tampere, Finland) in different configurations. Next, stabilities of fixation conducted by different systems were compared with together applying biomechanical loading tests. Then, stabilities of fixations which were applied with various systems were compared by applying biomechanical load tests. For this aim, 20N, 60N, 120N, 140N and 200N compressive loads were performed to each tooth on models by using of servohydrolic universal axial test machine. Experiments were carried out in biological test cabin which was full with continuously circulating physiological saline solution (PBS) at constant 37°C to mimic in vivo successfully. Compressive load behaviors of madibles which were in posterior and anterior region were recorded by using of non-contact video extensometer. According to the results, mandible group fixed by using screw was found more stabile than the group fixed by plate. Moreover, less strain accumulation was observed in neighborhood of the cut zone in posterior part of osteotomy applied mandible in comparison with further areas. In conclusion resorbable screw-plate systems provide sufficient stability in the fixation process. Only the fixation with screws is safer than plate+screw fixation.
矢状分裂支截骨术(SSRO)在治疗特定牙面畸形方面已取得成功并得到广泛应用。外科医生已经使用了许多技术和材料,如钢丝骨合成、微型钢板和螺钉,用于SSRO后的固定和稳定。虽然大多数术后并发症与迷你钛板和/或螺钉有关,需要第二次手术去除金属固定物的缺点已经被开发并用于研究可吸收材料在下颌矢状面劈开截骨固定和稳定中的应用。近年来,越来越多的外科医生倾向于使用可吸收材料进行骨调节,但可吸收材料在截骨或骨折后不同颌骨部位的可靠性仍然是外科医生关注的问题,这限制了此类外科医生使用可吸收材料系统。在文献中,关于使用可吸收钢板/螺钉系统进行矢状劈裂支截骨的临床结果分析和比较的研究还不够令人满意。本研究选用8个聚氨酯合成下颌假体(瑞士Synbone 8598),共分为2组。在对样品采用SSRO后,使用不同配置的可吸收钢板/螺钉系统(Inion CPS系统,坦佩雷,芬兰)实现骨段固定。接下来,比较不同系统进行固定的稳定性,并进行生物力学载荷试验。然后,通过生物力学载荷试验比较不同系统下固定物的稳定性。为此,利用伺服液压万向轴向试验机对模型的每个齿施加20N、60N、120N、140N和200N的压缩载荷。实验在生物实验室内进行,实验室内充满37°C连续循环的生理盐水溶液(PBS),成功模拟了体内情况。采用非接触式视频拉伸仪,记录了后、前两段材料的压缩载荷行为。结果表明,螺钉固定下颌骨组比钢板固定下颌骨组更稳定。此外,与其他区域相比,下颌后部截骨区附近的应变积累较少。总之,可吸收的螺钉-钢板系统在固定过程中提供了足够的稳定性。仅螺钉固定比钢板+螺钉固定更安全。
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引用次数: 0
Naive Bayes classification of neurodegenerative diseases by using discrete wavelet transform 基于离散小波变换的神经退行性疾病朴素贝叶斯分类
Pub Date : 2015-11-01 DOI: 10.1109/BIYOMUT.2015.7369440
S. Bilgin, Anil Can Guzeler
The main objective of this study is the detection and analysis of some neurodegenerative disorders. It is possible to determine the classification of Especially ALS (Amyotrophic Lateral Sclerosis), PD (Parkinson's Disease) and HD (Huntington's Disease) with respect to analysis of gait signals. Records obtained from gait signals can be converted the statistical values using DWT (Discrete Wavelet Transform). And also neurodegenerative gait signals are compared to control signals recorded from healthy subjects in the study. Other studies have been carried out for 5 minutes recordings in the literature. The innovative aspect of this study is to obtain the results of the recording by taking for 1 minute. So, this approach proposes a short measurement time for classification of neurodegenerative diseases. As a result, the classification of neurodegenerative diseases is obtained from gait signals using DWT and Naive Bayes method in the study and the discrimination of ALS disease can be achieved by using this method.
本研究的主要目的是检测和分析一些神经退行性疾病。通过对步态信号的分析,可以确定特别是ALS(肌萎缩性侧索硬化症)、PD(帕金森病)和HD(亨廷顿病)的分类。从步态信号中获得的记录可以使用DWT(离散小波变换)转换统计值。同时将神经退行性步态信号与研究中健康受试者记录的控制信号进行比较。其他研究在文献中进行了5分钟的录音。本研究的创新之处在于通过拍摄1分钟来获得记录的结果。因此,该方法为神经退行性疾病的分类提供了较短的测量时间。因此,本研究采用DWT和朴素贝叶斯方法从步态信号中获得神经退行性疾病的分类,并利用该方法实现对ALS疾病的鉴别。
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引用次数: 3
EOG controlled direction detect system with neuro-fuzzy approach 基于神经模糊方法的眼电控制方向检测系统
Pub Date : 2015-11-01 DOI: 10.1109/BIYOMUT.2015.7369442
Hande Erkaymaz, M. Ozer, Ceren Kaya
The eye, which has the most advanced features among sense organs, has a perfect functioning on people. Furthermore, as it is placed in the lead role of vision, shows the importance for people is quite big. Nowadays, biomedical devices developed for patients who have mobility are benefiting from eye movements. Electrooculogram studies are especially designed on the basis of the signal depending on the movement of your eyes. Electrical origin of EOG biological signal, that occur around the eye pupil, makes an attempt to meet the needs of patients by the right, left, up, down and blinking action. In this study, 4 basic differences existing in the direction of movement using voltage controlled EOG signal studies have tried to determine the Neuro-Fuzzy model. Determining the direction of Neuro-Fuzzy control system demonstrates how it can be successfully used as. In addition, control algorithms of artificial intelligence systems that use this kind of eye signals benefiting from the input of the detection process is advantageous in the classification of complex environment.
眼睛是感觉器官中最先进的器官,在人身上有着完美的功能。此外,由于它被置于视觉的主导地位,表明它对人们的重要性是相当大的。如今,为行动不便的患者开发的生物医学设备正受益于眼球运动。眼电图研究是专门根据眼睛运动的信号设计的。EOG生物信号的电源发生在眼球瞳孔周围,试图通过左右、上下、眨眼等动作来满足患者的需要。在本研究中,利用电压控制的EOG信号研究了运动方向上存在的4个基本差异,试图确定神经模糊模型。神经模糊控制系统的方向确定说明了它是如何成功地作为。此外,利用这种受益于检测过程输入的眼信号的人工智能系统的控制算法在复杂环境的分类中是有利的。
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引用次数: 1
Glucose measuring by faraday approach based magneto-optical method in-vitro environment for medical diagnosis 体外环境下基于法拉第法的磁光法血糖测量用于医学诊断
Pub Date : 2015-11-01 DOI: 10.1109/BIYOMUT.2015.7369438
I. Yariçi, B. Cetintas, A. J. Pahnvar, Y. Ozturk, M. Engin
In this study, in order to help the blood glucose measurement on diabetic patients by using optical activity of glucose and the changing polarization of light under a magnetic field, an optical system determining the glucose concentration in the blood phantom and operating in-vitro conditions is being developed [4,5]. In that designed optical system, the alteration of the polarization angle mechanically will lead to the user and system errors. Alternatively, the study aims to prevent the mechanical origin of this error via the magneto-optical polarization glass, whose Verdet constant is known, modified inside an coil. In the study, the polarization angle deviations from the sugar solution was measured by the Faraday approach based magneto-optical method in an in-vitro environment. It was observed that the calculated theoretical values and measured experimental data are compatible. Most blood glucose measuring methods cause discomfort (pain) for the patient as well as have the risk of infection[1]. Tthe optic based approach is one of the alternatively considered methods [2,3]. It shows that the solution of glucose concentration alternates the light polarization, which means the glucose is optically active. Another parameter that changes the polarization of light is the applied magnetic field via the propagation of light.
在本研究中,为了利用葡萄糖的光学活性和磁场下光的偏振变化来帮助糖尿病患者测量血糖,正在开发一种测定血模中葡萄糖浓度并在体外条件下运行的光学系统[4,5]。在设计的光学系统中,偏振角的机械改变会导致用户和系统的误差。另外,该研究旨在通过磁光偏振玻璃(其Verdet常数是已知的)在线圈内进行修改来防止这种误差的机械根源。在体外环境下,采用基于法拉第方法的磁光法测量了糖溶液的极化角偏差。结果表明,理论计算值与实验测量值基本一致。大多数血糖测量方法会给患者带来不适(疼痛),并有感染的风险[1]。基于光学的方法是可选择的方法之一[2,3]。结果表明,葡萄糖浓度溶液的光极化发生交替,表明葡萄糖具有旋光性。另一个改变光偏振的参数是通过光的传播施加的磁场。
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引用次数: 0
Poisson medical image matting with fuzzy input 模糊输入泊松医学图像抠图
Pub Date : 2015-11-01 DOI: 10.1109/BIYOMUT.2015.7369462
Kamil Aktas, B. Dizdaroğlu
In this study, fuzzy input data has been considered for processing of Poisson medical image matting. Image matting is actually known as an image segmentation approach. But, fine detail information can be extracted from the background of the given image in the image matting. Although global Poisson image matting approach is applied to smoothed images, successful matting results can be obtained from medical images that may not be contain more fine detail information. In this study, fuzziness is included to the input data as a percent value and a generated result is compared with the classical Poisson image matting approach.
本研究采用模糊输入数据进行泊松医学图像抠图处理。图像抠图实际上是一种图像分割方法。但是,在图像抠图中可以从给定图像的背景中提取出精细的细节信息。虽然将全局泊松图像抠图方法应用于光滑图像,但对于可能不包含更精细细节信息的医学图像,也可以获得成功的抠图结果。在本研究中,模糊度作为一个百分比值包含在输入数据中,并将生成的结果与经典泊松图像抠图方法进行比较。
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引用次数: 0
期刊
2015 19th National Biomedical Engineering Meeting (BIYOMUT)
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