International Journal of Urology最新文献

{"title":"Editorial Comment on Oligometastatic Prostate and Bladder Cancer: An Integrative Narrative Review","authors":"Hiroshi Hirata","doi":"10.1111/iju.70343","DOIUrl":"10.1111/iju.70343","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment on “Usefulness of the Toronto Voiding Symptom Score in the Diagnosis of Occult Tethered Cord Syndrome”","authors":"Ismail Selvi","doi":"10.1111/iju.70349","DOIUrl":"10.1111/iju.70349","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment to “Clinical Features and Risk Factors of Enfortumab Vedotin-Induced Peripheral Neuropathy in Patients With Metastatic Urothelial Carcinoma: A Multicenter Retrospective Study (YUSHIMA Study)”","authors":"Makito Miyake","doi":"10.1111/iju.70351","DOIUrl":"10.1111/iju.70351","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Analysis of Vesicourethral-Anastomosis Stricture/Urethral Stricture After Robotic-Assisted Laparoscopic Radical Prostatectomy With and Without Radiotherapy","authors":"Kinan Massouh,&nbsp;Katharina Leucht,&nbsp;Lutz Leistritz,&nbsp;Marc-Oliver Grimm","doi":"10.1111/iju.70339","DOIUrl":"10.1111/iju.70339","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Objective</h3>\u0000 \u0000 <p>Vesicourethral anastomotic stenosis and/or urethral stenosis (VUAS/US) is a complication of robotic-assisted radical prostatectomy (RARP) for prostate cancer. We aimed to evaluate the incidence of VUAS/US after RARP and to identify potential risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We performed a retrospective assessment of clinical records of patients with RARP as primary prostate cancer treatment (January 2011–December 2018) and investigated associations between VUAS/US formation and radiotherapy, pT-stage, tumor margins, Gleason score, nerve-sparing, and postoperative duration of bladder catheterization. Statistical analysis was performed via uni- and multivariable cox regression; risk estimation was done with the Kaplan–Meier method and log-rank test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results and Limitations</h3>\u0000 \u0000 <p>809 patients were included in the study. Median clinical follow-up was 61.0 months (IQR 50.0–75.0) and 175 (22%) patients received radiotherapy. VUAS and US were recorded in 19 (2.3%) and 10 (1.2%) patients, respectively. Whereas in univariable analysis radiotherapy, pT-stage ≥ pT3a, higher Gleason score, positive tumor margins, nerve-sparing, and prolonged duration of bladder catheterization were significant risk factors, in a multivariable analysis only radiotherapy (<i>p</i> = 0.003) and prolonged duration of bladder catheterization (<i>p</i> = 0.0309) proved to be independently predictive. Estimated 5-year risk of VUAS/US formation was lower without than with radiotherapy (2.1% [95% CI: 0.9–3.3] vs. 7.3% [95% CI: 3.4–11]) and with normal compared to prolonged bladder catheterization (2.6% [95% CI: 1.4–3.8] vs. 9.9% [95% CI: 2.3–18]). Retrospectivity and the limited number of events were our major limitations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Clinical Implications</h3>\u0000 \u0000 <p>Low incidence of VUAS/US in RARP. Patients undergoing radiotherapy or requiring prolonged catheterization should be explicitly informed about the risk of VUAS/US and about symptoms. Also, physicians must be aware.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iju.70339","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment on (Abiraterone Acetate Triggers ER Stress-Mediated Androgen Receptor Suppression via PERK/ATF4/CHOP Signaling in Prostate Cancer)","authors":"Fatih Kar","doi":"10.1111/iju.70352","DOIUrl":"10.1111/iju.70352","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evolution of Prostate Multiparametric MRI and Its Application in Prostate Cancer Clinical Management","authors":"Tsutomu Tamada,&nbsp;Mitsuru Takeuchi,&nbsp;Kazunori Moriya,&nbsp;Yu Ueda,&nbsp;Akira Yamamoto,&nbsp;Atsushi Higaki","doi":"10.1111/iju.70338","DOIUrl":"10.1111/iju.70338","url":null,"abstract":"<p>Prostate multiparametric MRI (mpMRI) is an indispensable diagnostic tool in the clinical management of patients suspected of prostate cancer (PCa). This mpMRI consists of T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and dynamic contrast-enhanced MRI (DCE-MRI). This review first outlines the importance of preparation techniques in mpMRI examinations and the evolution, current status, and latest technologies of these imaging techniques. It then addresses the clinical applications of diffusion tensor imaging, particularly its potential in surgical strategies for radical prostatectomy. Additionally, this review addresses the issues and clinical application potential of biparametric MRI, which omits DCE-MRI, in PCa diagnosis. It also discusses countermeasures for category 3 lesions with insufficient positive rates for clinically significant PCa in the Prostate Imaging-Reporting and Data System (PI-RADS) diagnostic criteria for prostate mpMRI, as well as the current status of MRI-ultrasound fusion guided prostate targeted biopsy in clinical practice using prostate mpMRI as a guide.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iju.70338","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Assessment of Cytomegalovirus Reactivation After Kidney Transplantation Under a Universal Preemptive Strategy in the Era of Intravenous Immunoglobulin-Based Desensitization Therapy","authors":"Yu Kijima,&nbsp;Toshihito Hirai,&nbsp;Shuhei Nozaki,&nbsp;Takafumi Yagisawa,&nbsp;Ayaka Saito,&nbsp;Kohei Unagami,&nbsp;Kazuya Omoto,&nbsp;Tomokazu Shimizu,&nbsp;Toshio Takagi,&nbsp;Hideki Ishida","doi":"10.1111/iju.70342","DOIUrl":"10.1111/iju.70342","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cytomegalovirus (CMV) infection remains a key opportunistic complication after kidney transplantation. We evaluated risk factors for CMV reactivation in a universal preemptive strategy for the recent patient cohort including immunologically crossmatch positive high-risk recipients who underwent Intravenous Immunoglobulin (IVIG)-based desensitization with rituximab (Rit).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this retrospective cohort study, 395 adult KTx recipients treated between 2019 and 2021 were enrolled. All 395 recipients were divided into 3 groups as follows: group 1 receiving IVIG (+)/Rit (+), <i>n</i> = 32 (8.1%); group 2 Rit (+) only, <i>n</i> = 270 (68.6%); group 3 receiving none, <i>n</i> = 93 (23.5%). The purpose of this study is to examine the influence of immunosuppressants including IVIG and/or Rit on CMV infection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Totally, CMV antigenemia was observed in 51 of 395 recipients (12.9%). Among them, 8 out of 32 recipients in group 1 (25.0%) showed CMV antigenemia, 29 out of 270 recipients in group 2 (10.7%), and 14 out of 93 recipients in group 3 (15.1%). There was a higher tendency of CMV antigenemia incidence in group 1, compared to groups 2 and 3, although not statistical significance. Univariate and multivariate logistic regression identified pre-transplant CMV-IgG seronegativity (OR 2.58; 95% CI 1.36–4.88; <i>p</i> = 0.004) and Immunological high-risk (OR 2.56; 95% CI 1.10–5.95; <i>p</i> = 0.038) as independent risk factors for CMV reactivation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Seronegative status and immunosuppression against high immunological risk increased reactivation risk. Prophylactic treatment could be useful to prevent postoperative early complication in highly sensitized recipients using IVIG.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 2","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment to “Daytime Bladder Control Status in Toddlerhood Is Associated With Subsequent Bedwetting in Preschool Years: A Nationwide Cohort Study of Over 30 000 Japanese Children”","authors":"Kenichi Kobayashi","doi":"10.1111/iju.70333","DOIUrl":"10.1111/iju.70333","url":null,"abstract":"<p>The possibility that early-life urinary habits and developmental patterns may influence later urinary function, including the persistence of bedwetting and voiding dysfunction, has been discussed for many years [<span>1, 2</span>]. However, according to the International Children's Continence Society (ICCS), nocturnal enuresis (NE) is defined as urinary incontinence during sleep in children aged 5 years or older [<span>3</span>]. Therefore, there has been little solid data or evidence regarding urinary symptoms or nighttime wetting before this age.</p><p>In this context, the present study provides valuable and timely insights using a large-scale national cohort that offers robust and reliable data [<span>4</span>].</p><p>The authors examined daytime bladder control at 2.5 years of age, bedwetting at 4.5 years, and the relationship between these two factors. They found that 82.8% of children were still using diapers at 2.5 years, and that the prevalence of bedwetting at 4.5 years was 42.2%. These findings, based on high-quality longitudinal data, shed light on an important but underexplored developmental stage that precedes the conventional definition of enuresis. Moreover, the authors demonstrated that incomplete daytime bladder control at 2.5 years was associated with an increased risk of the persistence of bedwetting.</p><p>The data were drawn from the “Longitudinal Survey of Newborns in the 21st Century,” a nationwide birth cohort conducted by the Ministry of Health, Labour and Welfare in Japan, including more than 30 000 children. The use of such a large, well-constructed dataset is one of the major strengths of this study and strongly supports the reliability of its findings. As mentioned earlier, studies focusing on urinary control at this early age are extremely limited. Therefore, this study makes a highly valuable contribution simply by providing reliable data in this field.</p><p>Readers should remember that this is an observational study. The assessment of bladder control was based on diaper use, which reflects the actual use of diapers rather than a direct measurement of bladder function. The study does not address how diaper use itself might influence urinary control development. This is an important point to keep in mind when interpreting the findings.</p><p>Overall, this study provides a unique and informative perspective on early childhood urinary development. It highlights the importance of understanding how early-life bladder control may relate to later urinary symptoms, and it offers a strong foundation for future longitudinal or interventional research in this area.</p><p>The author takes full responsibility for this article.</p><p>The author declares no conflicts of interest.</p><p>This article is linked to Moriwake et al. papers. To view this article, visit https://doi.org/10.1111/iju.70288.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145856317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment on: Use and Persistence of Beta-3 Adrenoceptor Agonists for the Treatment of Overactive Bladder","authors":"Takanori Mochizuki","doi":"10.1111/iju.70337","DOIUrl":"10.1111/iju.70337","url":null,"abstract":"&lt;p&gt;The β3-adrenoceptor agonists mirabegron and vibegron represent important therapeutic options for patients with overactive bladder (OAB), yet clinicians often face challenges in distinguishing how best to use each agent in daily practice. The present study provides timely real-world data directly comparing these two agents at equivalent daily doses of 50 mg, offering one of the few opportunities to evaluate their effectiveness and persistence under routine clinical conditions [&lt;span&gt;1&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;A particularly notable finding is the relatively high discontinuation or switching rate observed among mirabegron users, with approximately 47.9% discontinuing the medication. The availability of vibegron as an alternative therapeutic agent likely contributed to this pattern, highlighting a prescribing dynamic that has not been previously captured in detail. The study thereby provides valuable insights into how the introduction of a second β3 agonist may influence clinical decision-making, adherence, and treatment persistence. The inclusion of sex-stratified analyses also enriches the study, offering more granular clinical information that may support individualized treatment selection.&lt;/p&gt;&lt;p&gt;Several randomized trials have compared mirabegron and vibegron in female OAB populations, generally demonstrating comparable overall efficacy, although vibegron may provide greater improvements in urinary frequency and urgency urinary incontinence in some cases [&lt;span&gt;2-4&lt;/span&gt;]. However, although several comparative studies have focused on female patients, direct comparative evidence in male populations remains extremely limited, making the real-world male-predominant data presented in this study particularly informative.&lt;/p&gt;&lt;p&gt;As expected in retrospective real-world research, several limitations should be acknowledged, including potential selection bias arising from clinicians' prescribing preferences and the absence of standardized criteria for determining treatment discontinuation. Confounding factors—such as comorbidities or prior treatment exposure—may also have influenced persistence outcomes. Nevertheless, the authors provide important observational evidence supporting real-world treatment behaviors, including frequent switching from mirabegron to vibegron (40.7%) and the contribution of having multiple β3 agonist options to extended overall β3 agonist persistence.&lt;/p&gt;&lt;p&gt;The authors' earlier work reported favorable long-term persistence with mirabegron before vibegron became available, and the current findings likely reflect the evolving therapeutic landscape. These results illustrate how the presence of multiple β3 agonist options may improve long-term management by enabling treatment switching rather than treatment discontinuation. Such insights could help optimize OAB care, particularly given the known challenges with adherence and persistence across pharmacologic treatments for OAB.&lt;/p&gt;&lt;p&gt;Ultimately, while the present study does not establish supe","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145846662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment to the Change of Nocturnal Penile Tumescence During Dutasteride Administration","authors":"Juntaro Koyama","doi":"10.1111/iju.70336","DOIUrl":"10.1111/iju.70336","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"33 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145846218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}