International Journal of Rheumatic Diseases最新文献

英文中文

Additional Considerations on the Comparative Effectiveness of TNF-α and IL-6 Inhibitors on Bone Health and Mortality in Rheumatoid Arthritis TNF-α和IL-6抑制剂对类风湿关节炎患者骨骼健康和死亡率的比较效果的其他考虑

IF 2 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2025-12-07 DOI: 10.1111/1756-185x.70472

Yunxi He, Yueyun Qiu, Yiyan Zhang

引用次数: 0

The Silent Gap: An Exploratory Analysis of Severe Periodontal Breakdown in Rheumatoid Arthritis Despite Stable Gingival Crevicular Fluid Levels 沉默的间隙：尽管牙龈沟液水平稳定，但类风湿关节炎患者严重牙周破裂的探索性分析。

IF 2 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2025-12-02 DOI: 10.1111/1756-185x.70494

Victória Boëchat Feyo, Lydia Silva Provinciali, Laura Silva Siano Rodrigues, José Jonas Pereira, Pâmela Souza Almeida Silva Gerheim, Viviane Angelina de Souza, Rafael de Oliveira Fraga, Nádia Rezende Barbosa Raposo, Gisele Maria Campos Fabri

Aim

To quantitatively assess gingival crevicular fluid (GCF), periodontal condition, and clinical parameters of Rheumatoid Arthritis (RA) and verify the correspondence between systemic and dental aspects. Investigating the influence of systemic inflammation, polypharmacy, and anticholinergic load on GCF may help to better understand the exacerbation of periodontal destruction in patients with RA.

Methods

A cross-sectional study evaluated 33 participants (18 RA, 15 controls). Demographic data, RA activity, functional capacity, anticholinergic burden, polypharmacy (PP), orofacial physical examination, and complete periodontal evaluation were assessed. GCF volume was measured using a Periotron (Oralflow Inc., New York, NY, USA). Statistical analysis included parametric and non-parametric tests, as well as multiple correspondence analysis (p < 0.05).

Results

RA patients exhibited worse periodontal status, with 50% having periodontitis, while 80% of controls had gingivitis, despite similar GCF levels between groups. Multiple correspondence analysis revealed strong associations between advanced periodontitis (stages III/IV grade B), high biofilm (> 20%), bleeding index (> 10%), pocket depth > 4 mm, severe gingival inflammation, higher RA activity, severe functional impairment, PP, and elevated anticholinergic activity. Periodontal health and RA remission were associated with low inflammatory markers, less medication use and absence of immunosuppressive therapy.

Conclusion

RA patients had greater periodontal impairment despite similar GCF volumes. Strong associations were observed between periodontal severity, RA activity, PP, and anticholinergic burden, suggesting GCF involvement in periodontal disease progression in RA, highlighting underexplored clinical connections.

目的：定量评价类风湿性关节炎（RA）的龈沟液（GCF）、牙周状况和临床参数，验证系统和牙齿方面的对应关系。研究全身性炎症、多种药物和抗胆碱能负荷对GCF的影响可能有助于更好地了解RA患者牙周破坏的加剧。方法：一项横断面研究评估了33名参与者（18名RA， 15名对照组）。统计资料、类风湿关节炎活动度、功能能力、抗胆碱能负荷、多药（PP）、口腔面部体格检查和完整的牙周评估。使用Periotron （Oralflow Inc., New York， NY， USA）测量GCF体积。统计分析包括参数检验和非参数检验，以及多重对应分析(p)结果：RA患者牙周状况更差，50%的患者患有牙周炎，而80%的对照组患有牙龈炎，尽管组间GCF水平相似。多重对应分析显示，晚期牙周炎（III/IV期B级）、高生物膜（> 20%）、出血指数（> 10%）、袋深> 4mm、严重牙龈炎症、RA活性升高、严重功能损害、PP和抗胆碱能活性升高之间存在强相关性。牙周健康和RA缓解与低炎症标志物、较少药物使用和缺乏免疫抑制治疗相关。结论：尽管GCF体积相似，RA患者牙周损害更大。观察到牙周严重程度、RA活动性、PP和抗胆碱能负荷之间存在强相关性，提示GCF参与RA牙周病进展，突出了未被探索的临床联系。

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引用次数: 0

Palatal Telangiectasias as an Ominous Sign of Refractory Dermatomyositis! 腭毛细血管扩张是难治性皮肌炎的不祥之兆！

IF 2 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2025-12-01 DOI: 10.1111/1756-185x.70497

Nidhi Goel, J. Sankar, Aditya Joshi, Indranil Ghosh, M. G. Vishnoi, Shaman Gill, A. V. S. Anil Kumar

引用次数: 0

Cogan's Syndrome With Neurological Manifestations and Concurrent Axial Spondyloarthritis: A Case Report Cogan综合征伴神经系统表现并并发轴性脊柱炎1例报告

IF 2 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2025-11-28 DOI: 10.1111/1756-185X.70491

Tugce Bozkurt, Sevilay Batibay, Elif Dincses-Nas, Esen Kasapoglu

引用次数: 0

Comprehensive Analysis of Thrombocytopenia in Systemic Lupus Erythematosus: Prevalence, Immunological Correlations, and Mortality Outcomes in the Oman Lupus Cohort 系统性红斑狼疮患者血小板减少的综合分析：阿曼狼疮队列的患病率、免疫学相关性和死亡率结果

IF 2 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2025-11-28 DOI: 10.1111/1756-185x.70490

Nasra K. Al-Adhoubi, Juma Al Kaabi, Issa Al Salmi, Reem Abdwani, Farida Al-Balushi, Maha Ali, Talal Al Lawati, B. S. H. Al Lawati, Ali Al Shamsi, Musallam Al Mashaani, Divij Krishna Jha, Sherin Sayed, Tariq Al-Araimi, Prabha Liyanage, Hilal Al Kalbani, Humaid A. Al Wahshi

Background

In systemic lupus erythematosus (SLE), thrombocytopenia is a common hematological complication associated with severe disease manifestations and increased mortality.

Objectives

The study aimed to investigate the prevalence of thrombocytopenia in the Oman lupus cohort and explore its correlation with clinical, immunological, and epidemiological characteristics, as well as mortality and survival outcomes.

Methods

The study forms a section of the Oman Lupus Study, which is a longitudinal research initiative that includes 1 160 patients diagnosed with SLE between January 2006 and February 2020. The patients were evaluated for the prevalence of thrombocytopenia, which was further analyzed in relation to epidemiological and clinical characteristics, laboratory profile, survival, and mortality outcomes.

Results

Thrombocytopenia was found in 22.5% of patients (262/1 160), with no significant difference between males (12%) and females (88%, p = 0.642). There were significant correlations between thrombocytopenia and antiphospholipid antibodies, as well as organ involvement, such as renal (5.3% vs. 0.6%, p = 0.000), neuropsychiatric (30.9% vs. 17.9%, p = 0.000), and respiratory complications (25.6% vs. 16.4%, p = 0.001). A similar prevalence rate was identified between pediatric and adult patients (20.2% vs. 22.8%, p = 0.490). It has been demonstrated that the mortality rate in thrombocytopenia patients was significantly higher (11.1% vs. 2.9%, p = 0.000), translating to a nearly fourfold increased risk. The Kaplan–Meier curve indicated that patients with thrombocytopenia had a reduced survival rate.

Conclusions

Thrombocytopenia impacts nearly a quarter of lupus patients and is strongly associated with organ involvement and increased mortality risk, irrespective of gender or age. These findings underscore the necessity for additional research and specialized guidelines to enhance outcomes in this high-risk group.

背景：在系统性红斑狼疮（SLE）中，血小板减少是一种常见的血液学并发症，与严重的疾病表现和死亡率增加有关。本研究旨在调查阿曼狼疮患者中血小板减少症的患病率，并探讨其与临床、免疫学和流行病学特征以及死亡率和生存结局的相关性。该研究是阿曼狼疮研究的一部分，阿曼狼疮研究是一项纵向研究计划，包括2006年1月至2020年2月期间诊断为SLE的1160例患者。评估患者的血小板减少率，并进一步分析其与流行病学和临床特征、实验室资料、生存和死亡率结果的关系。结果22.5%（262/1 160）患者存在血小板减少症，男性（12%）与女性（88%）差异无统计学意义（p = 0.642）。血小板减少症与抗磷脂抗体以及器官受累之间存在显著相关性，如肾脏（5.3%对0.6%,p = 0.000）、神经精神（30.9%对17.9%,p = 0.000）和呼吸系统并发症（25.6%对16.4%,p = 0.001）。儿童和成人患者的患病率相似（20.2%对22.8%,p = 0.490）。已经证明，血小板减少症患者的死亡率明显更高（11.1%对2.9%,p = 0.000），转化为近四倍的风险增加。Kaplan-Meier曲线显示血小板减少患者生存率降低。结论：近四分之一的狼疮患者患有血小板减少症，与器官受累和死亡风险增加密切相关，与性别和年龄无关。这些发现强调了进一步研究和专门指南的必要性，以提高对这一高危人群的治疗效果。

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引用次数: 0

Syphilitic Arthropathy: A Single-Center Experience 梅毒关节病：单中心体验

IF 2 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2025-11-27 DOI: 10.1111/1756-185x.70489

S. Kobak, Z. C. Karakoc

引用次数: 0

Correspondence on “Long- Term Prognostic and Hemodynamic Outcomes of Intensive Immunosuppressive Therapy in Patients With Pulmonary Arterial Hypertension Associated With Connective Tissue Disease” “强化免疫抑制治疗结缔组织病肺动脉高压患者的长期预后和血流动力学结果”的对应文章。

IF 2 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2025-11-25 DOI: 10.1111/1756-185x.70475

Ching-Wei Wu, Renin Chang

引用次数: 0

Surgical Emergency for Sudden Blindness in Systemic Lupus Erythematosus 系统性红斑狼疮突发性失明的外科急诊治疗。

IF 2 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2025-11-25 DOI: 10.1111/1756-185x.70482

Shazila Khan, Puneet Kumar, Anupam Mishra

引用次数: 0

Genome-Wide Association Analysis and Multi-Omic Mendelian Randomization Insight Into the Molecular Network of Immune-Related Dysfunction in the Pathogenesis of Rheumatoid Arthritis 类风湿关节炎发病中免疫相关功能障碍分子网络的全基因组关联分析和多组孟德尔随机化。

IF 2 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2025-11-25 DOI: 10.1111/1756-185x.70479

Xiaohong Song, Shanshan Lv, Lin Du, Libin Chen, Zijing Gao, Jie Guo, Zhaolan Hu, Yanwei Luo

Background

Rheumatoid arthritis (RA) is a complex autoimmune disease influenced by genetic and immune dysregulation. The causal roles of specific immune-related genes in RA pathogenesis remain incompletely understood.

Methods

We conducted a large-scale genome-wide association study (GWAS) meta-analysis across three RA cohorts to identify genome-wide significant risk loci. Causal genes and proteins were prioritized by integrating these results with cis-eQTL and pQTL datasets using two-sample Mendelian randomization (MR) and summary-data-based MR (SMR). Cell-type-specific expression was assessed using single-cell RNA sequencing (scRNA-seq), and gene expression in RA synovial tissue was validated via bulk RNA-seq.

Results

We identified 29 independent RA-associated loci, including 7 novel associations. Integrated MR and SMR analyses classified ERAP2 as a high-confidence causal gene, while SWAP70 and LTBR were deemed moderate-confidence causal genes. SWAP70 showed a protective association, whereas ERAP2 and LTBR were positively associated with RA risk. Single-cell transcriptomic analysis revealed cell-type-specific enrichment, with SWAP70 prevalent in B cells and LTBR in dendritic cells. Bulk RNA-seq confirmed the upregulation of SWAP70, RASGRP1, and RHOH in RA patients.

Conclusion

Our integrative multi-omics framework reveals immune regulatory genes with potential causal roles in RA pathogenesis, highlighting ERAP2, SWAP70, LTBR, and other candidates as promising therapeutic targets.

背景：类风湿性关节炎（RA）是一种复杂的自身免疫性疾病，受遗传和免疫失调的影响。特异性免疫相关基因在RA发病机制中的因果作用仍不完全清楚。方法：我们对三个RA队列进行了大规模全基因组关联研究（GWAS）荟萃分析，以确定全基因组显著风险位点。通过使用两样本孟德尔随机化（MR）和基于汇总数据的MR （SMR）将这些结果与顺式eqtl和pQTL数据集整合，对因果基因和蛋白质进行优先排序。使用单细胞RNA测序（scRNA-seq）评估细胞类型特异性表达，并通过大量RNA-seq验证RA滑膜组织中的基因表达。结果：我们鉴定了29个独立的ra相关位点，其中包括7个新的关联位点。综合MR和SMR分析将ERAP2归类为高置信度的因果基因，而SWAP70和LTBR被认为是中等置信度的因果基因。SWAP70显示保护性关联，而ERAP2和LTBR与RA风险呈正相关。单细胞转录组分析显示细胞类型特异性富集，SWAP70普遍存在于B细胞中，LTBR普遍存在于树突状细胞中。Bulk RNA-seq证实了RA患者SWAP70、RASGRP1和RHOH的上调。结论：我们的综合多组学框架揭示了在RA发病机制中具有潜在因果作用的免疫调节基因，强调了ERAP2， SWAP70， LTBR和其他候选靶点是有希望的治疗靶点。

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引用次数: 0

When Skin and Eyes Speak: Uncovering a Hidden Diagnosis 当皮肤和眼睛说话：揭露隐藏的诊断。

IF 2 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2025-11-24 DOI: 10.1111/1756-185x.70483

Nidhish Chandra Mathilakath, Puneet Kumar, Vishal Anand

引用次数: 0

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International Journal of Rheumatic Diseases

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