International Journal of Rheumatic Diseases最新文献

英文中文

Computed tomography imaging-based radiologic evaluation of pulmonary artery thrombosis in a series of patients with Behcet's disease 基于计算机断层扫描成像对一系列白塞氏病患者肺动脉血栓形成的放射学评估

IF 2.4 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2024-07-19 DOI: 10.1111/1756-185X.15267

Serife Asya Germe, Zehra Ozsoy, Bugu Bulat, Gamze Durhan, Büşra Fırlatan, Levent Kilic, Ali Akdogan

Aim

Pulmonary artery involvement is a severe complication of Behcet's disease (BD). Although venous thrombosis is common in BD, pulmonary embolism is considered to be rare because the inflammatory nature makes the thrombi strongly adherent to the venous walls. This study aimed to define the radiological characteristics of pulmonary artery thrombosis (PAT) on computed tomography (CT) imaging in BD patients.

Methods

We retrospectively evaluated 165 BD patients with vascular involvement. Among the patients with venous involvement (n = 146), we identified 65 patients who had undergone thorax CT imaging previously. Fourteen patients who were diagnosed with PAT were included in the study. Expert radiologists re-evaluated the patients' initial and control thorax CT scans, classified the PAT as acute or chronic based on their radiological features.

Results

The patients' median age was 35 (min–max: 15–60) years at the time of the initial CT scan, and nine were male. Twelve (85.7%) patients were symptomatic at the time of CT evaluation. Upon re-evaluating the thorax CTs, acute PAT was diagnosed in six (42.8%); chronic PAT was detected in eight (57.1%) patients. Two patients with chronic PAT also had acute PAT. Pulmonary artery aneurysms were present in three (21.4%) patients, and intracardiac thrombus was found in three (21.4%) patients.

Conclusion

A significant number of BD patients with venous involvement had radiological findings consistent with acute PAT potentially due to pulmonary emboli in this study. The clinical importance of these lesions has to be defined with future studies.

目的肺动脉受累是白塞氏病（BD）的一种严重并发症。虽然静脉血栓形成在白塞氏病中很常见，但肺栓塞却被认为是罕见的，因为炎症性使血栓牢固地附着在静脉壁上。本研究旨在通过计算机断层扫描（CT）成像确定 BD 患者肺动脉血栓形成（PAT）的放射学特征。方法我们对 165 例有血管受累的 BD 患者进行了回顾性评估。在静脉受累的患者（146 人）中，我们发现 65 名患者之前接受过胸部 CT 成像检查。其中 14 例患者被诊断为 PAT。放射科专家重新评估了患者的初始和对照胸部 CT 扫描结果，并根据其放射学特征将 PAT 分为急性和慢性。结果患者初次 CT 扫描时的中位年龄为 35 岁（最小-最大：15-60 岁），其中 9 人为男性。12 名患者（85.7%）在接受 CT 评估时无症状。重新评估胸部 CT 后，6 名患者（42.8%）被诊断为急性 PAT，8 名患者（57.1%）被诊断为慢性 PAT。两名慢性 PAT 患者也患有急性 PAT。3 名患者（21.4%）存在肺动脉瘤，3 名患者（21.4%）发现心内血栓。结论在本研究中，大量静脉受累的 BD 患者的放射学检查结果与可能由肺栓塞引起的急性 PAT 一致。这些病变的临床重要性有待今后的研究来确定。

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引用次数: 0

Membranous nephropathy with Kimura's disease: A case report and review of literature 膜性肾病伴木村氏病：病例报告和文献综述

IF 2.4 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2024-07-19 DOI: 10.1111/1756-185X.15265

Sathish Kumar Loganathan, Sanjib Mondal, Suprit Basu, Abarna Thangaraj, Pandiarajan Vignesh, Ritambhra Nada, Deepti Suri

Kimura's disease (KD) is a chronic inflammatory disorder characterized by nontender lymphadenopathy involving the head and neck region. Renal involvement in KD is rare, especially in children. We report a 12-year-old boy who had been previously treated for classical KD and had presented with anasarca and oliguria after 4 years. There were no swellings or lymphadenopathy. The kidney biopsy revealed membranous nephropathy. Remission was achieved with oral prednisolone and tacrolimus therapy. This patient highlights the need to regularly monitor patients with KD for the evolution of renal diseases, even if lymphadenopathy regresses. Serial monitoring for eosinophilia, inflammatory markers, and urine examination is needed to help identify subclinical disease early and prompt initiation of specific therapy.

木村氏病（Kimura's disease，KD）是一种慢性炎症性疾病，其特征是累及头颈部的非触痛性淋巴结病。肾脏受累在 KD 中非常罕见，尤其是在儿童中。我们报告了一名曾接受过典型 KD 治疗的 12 岁男孩，4 年后出现无尿和少尿。他没有肿块或淋巴结病。肾活检显示他患有膜性肾病。经口服泼尼松龙和他克莫司治疗后，病情得到缓解。这名患者的病例突出表明，即使淋巴结病已经消退，也需要定期监测 KD 患者的肾脏疾病演变情况。需要对嗜酸性粒细胞增多、炎症标志物和尿液检查进行连续监测，以帮助及早发现亚临床疾病，并及时启动特异性治疗。

引用次数: 0

Lumbar facet arthritis after coronavirus disease 2019 vaccination—Utilization of ultrasound 2019 年冠状病毒疾病疫苗接种后的腰椎面关节炎--超声波的应用。

IF 2.4 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2024-07-18 DOI: 10.1111/1756-185X.15269

Shogo Shirota, Hiroaki Nishioka

引用次数: 0

Case report: Transient perivascular inflammation of the carotid artery syndrome can mimic vasculitis 病例报告：一过性颈动脉血管周围炎综合征可模拟脉管炎。

IF 2.4 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2024-07-18 DOI: 10.1111/1756-185X.15263

Ezgi Çimen Güneş, Seda Çolak, Emre Tekgöz, Uğur Bozlar, Sedat Yılmaz

引用次数: 0

Usefulness of skeletal muscle ultrasound as a screening test for sarcopenia in patients with rheumatoid arthritis 骨骼肌超声波作为类风湿性关节炎患者肌少症筛查测试的实用性。

IF 2.4 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2024-07-18 DOI: 10.1111/1756-185X.15257

Takeshi Yoshida, Masataka Inoue, Yoshitaka Kumon, Naoko Takamatsu, Taiki Nozaki, Jemima Albayda, Yuishin Izumi

引用次数: 0

Association of education attainment and risk of connective tissue diseases 受教育程度与结缔组织疾病风险的关系。

IF 2.4 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2024-07-17 DOI: 10.1111/1756-185X.15264

Yuanyuan Zeng, Xiaolan Yang, Shengda Tao, Ling Lei

Objective

We employed two-sample Mendelian randomization (MR) to assess the genetic causal relationship between educational attainment (EA) and risk of five common connective tissue diseases (CTDs).

Methods

Educational attainment (self-reported at age ≥30 years) was obtained from a meta-analysis of years of schooling in 766 345 participants of European ancestry from genome-wide association studies (GWAS). A total of 1265 signals associated with EA were identified. Genetic data for five CTDs [rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), polymyositis (PM), and dermatomyositis (DM)] were obtained from the FinnGen consortium. Two-sample MR analyses were performed separately for EA and the five CTDs.

Results

We found a negative causal relationship between EA and RA (OR_IVW = 0.627, 95% CI = 0.537–0.732, p < .001), and SLE (OR_IVW = 0.341, 95% CI = 0.123–0.944, p = .038). There were no genetic causal association between EA and SSc (OR_IVW = 0.647, 95% CI = 0.351–1.195, p = .164), PM (OR_IVW = 0.938, 95% CI = 0.320–2.746, p = .907), or DM (OR_IVW = 0.754, 95% CI = 0.351–1.619, p = .468). None of the analyses revealed any horizontal pleiotropy or heterogeneity.

Conclusion

Our findings indicated a potential causal association between EA and RA, SLE, emphasizing the need for further investigation and potential integration of EA into clinical practice to enhance treatment strategies.

目的：我们采用双样本孟德尔随机法（MR）评估教育程度（EA）与五种常见结缔组织疾病（CTD）风险之间的遗传因果关系：我们采用双样本孟德尔随机法（MR）评估了受教育程度（EA）与五种常见结缔组织疾病（CTD）风险之间的遗传因果关系：教育程度（≥30 岁时的自我报告）是通过对全基因组关联研究（GWAS）中 766 345 名欧洲血统参与者的受教育年限进行荟萃分析获得的。共确定了 1265 个与 EA 相关的信号。五种 CTD [类风湿性关节炎（RA）、系统性红斑狼疮（SLE）、系统性硬化症（SSc）、多发性肌炎（PM）和皮肌炎（DM）]的基因数据来自芬兰基因联盟（FinnGen consortium）。对EA和五种CTD分别进行了双样本MR分析：我们发现 EA 与 RA 之间存在负因果关系（ORIVW = 0.627，95% CI = 0.537-0.732，p IVW = 0.341，95% CI = 0.123-0.944，p = .038）。EA与SSc（ORIVW = 0.647，95% CI = 0.351-1.195，p = .164）、PM（ORIVW = 0.938，95% CI = 0.320-2.746，p = .907）或DM（ORIVW = 0.754，95% CI = 0.351-1.619，p = .468）之间没有遗传因果关系。所有分析均未显示任何水平多向性或异质性：我们的研究结果表明，EA 与 RA 和系统性红斑狼疮之间存在潜在的因果关系，强调了进一步研究的必要性，以及将 EA 纳入临床实践以加强治疗策略的可能性。

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引用次数: 0

Correction to “Pregnancy outcomes following tofacitinib use for synovitis, acne, pustulosis, hyperostosis and osteitis syndrome: Case report” 更正 "使用托法替尼治疗滑膜炎、痤疮、脓疱病、骨质增生和骨炎综合征后的妊娠结局：病例报告"。

IF 2.4 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2024-07-16 DOI: 10.1111/1756-185X.15266

Zhang C, Shi X, Ding Y, Lin Z, Qian T, Liu X, Hou X, Li C. Pregnancy outcomes following tofacitinib use for synovitis, acne, pustulosis, hyperostosis and osteitis syndrome: Case report. Int J Rheum Dis. 2024;27(6):e15209.

There were errors in the affiliation and correspondence information for the author, Chen Li. The affiliation “Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China” for the author, Chen Li, should be removed.

The correct affiliation and correspondence information for the author, Chen Li, should be “Department of Rheumatology, Fangshan Hospital Beijing University of Chinese Medicine, Beijing, China.”

We apologize for these errors.

Zhang C, Shi X, Ding Y, Lin Z, Qian T, Liu X, Hou X, Li C.使用托法替尼治疗滑膜炎、痤疮、脓疱病、骨质增生和骨炎综合征后的妊娠结局：病例报告。Int J Rheum Dis.2024;27(6):e15209.作者陈丽的单位和通讯信息有误。作者陈丽的单位 "中国北京中医药大学第三附属医院 "应删除。作者陈丽的正确单位和通讯信息应为 "中国北京中医药大学房山医院风湿科"，我们对此错误深表歉意。

引用次数: 0

Abatacept retention and clinical effectiveness in patients with rheumatoid arthritis in a real-world setting in Taiwan 在台湾实际环境中，类风湿关节炎患者的阿巴他赛保留率和临床疗效。

IF 2.4 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2024-07-16 DOI: 10.1111/1756-185X.15199

Kun-Hung Chen, Ko-Jen Li, Yao-Fan Fang, Song-Chou Hsieh, Ying-Chou Chen, Chyou-Shen Lee, Shue-Fen Luo, Tien-Tsai Cheng, Wen Chan Tsai, Yu-Chen Lo, Joung-Liang Lan

Aim

To evaluate real-world abatacept retention and clinical outcomes in patients with rheumatoid arthritis in Taiwan.

Methods

This prospective, observational study enrolled patients with rheumatoid arthritis aged ≥20 years who received abatacept in real-world practice. The primary endpoint was the abatacept retention rate at 24 months. Patients were categorized into subgroups based on abatacept treatment status and previous biological disease-modifying antirheumatic drug (bDMARD) therapy. Risk factors affecting abatacept retention were determined by regression analysis.

Results

A total of 212 patients were enrolled. The overall abatacept retention rate at 24 months among all patients was 59.9% (95% confidence interval 53.0%–66.6%). Patients who were ongoing users of abatacept and bDMARD-naïve had the highest retention rate (76.3%); of these, 31.6% achieved low disease activity or remission after 2 years. Previous treatment with bDMARDs was associated with an increased risk of abatacept discontinuation (hazard ratio 1.99; p = .002). The most common reasons for abatacept discontinuation were drug switch (11.3%) and loss to follow-up (6.1%). Abatacept was well-tolerated with no new safety signals.

Conclusion

The 24-month retention rate of abatacept was 59.9%; abatacept was associated with improved clinical outcomes and was well-tolerated in the real-world setting in Taiwan.

目的：评估台湾类风湿关节炎患者在现实世界中的阿巴他赛保留率和临床疗效：这项前瞻性观察研究招募了年龄≥20岁的类风湿关节炎患者，这些患者在现实世界中接受了阿帕他赛治疗。主要终点是阿巴他赛在24个月后的保留率。根据阿帕塞普治疗情况和既往接受过的生物改良抗风湿药（bDMARD）治疗情况，将患者分为不同的亚组。通过回归分析确定了影响阿巴他赛保留率的风险因素：共有212名患者入组。所有患者在24个月时的阿巴他赛总保留率为59.9%（95%置信区间为53.0%-66.6%）。持续使用阿巴他赛且对bDMARD不敏感的患者保留率最高（76.3%）；其中31.6%的患者在2年后疾病活动度较低或病情缓解。曾接受过 bDMARDs 治疗与阿帕他赛停药风险增加有关（危险比 1.99；p = .002）。阿帕他赛停药的最常见原因是换药（11.3%）和失去随访（6.1%）。阿巴他赛普耐受性良好，没有出现新的安全信号：结论：阿帕赛普的24个月保留率为59.9%；阿帕赛普可改善临床疗效，在台湾的实际环境中耐受性良好。

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引用次数: 0

Squamous cell carcinoma: A malignant mimicker of giant cell arteritis 鳞状细胞癌：巨细胞动脉炎的恶性模仿者。

IF 2.4 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2024-07-14 DOI: 10.1111/1756-185X.15260

Halah Alfatlawi, Danyal Butt, Anan Bseiso, Rawish Fatima, Nezam Altorok

引用次数: 0

Immunoadsorption combined with antirheumatic drugs in the treatment of psoriatic arthritis with rheumatoid arthritis: A case report 免疫吸附联合抗风湿药物治疗银屑病关节炎合并类风湿性关节炎：病例报告。

IF 2.4 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases

Pub Date : 2024-07-14 DOI: 10.1111/1756-185X.15259

Li Cui, Hongmei Zhu, Aihua Du, Huixiang Chen, Xiaoying Yang, Yu Lei

引用次数: 0

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International Journal of Rheumatic Diseases

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