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A Study on the Diagnostic Value of Dual-Energy CT (DECT) Imaging in Patients With Gouty Arthritis
IF 2.4 4区 医学 Q2 RHEUMATOLOGY Pub Date : 2024-12-01 DOI: 10.1111/1756-185X.15431
YiXin Luan, XingShuai Gao
<div> <section> <h3> Objectives</h3> <p>To explore the diagnostic value of dual-energy computed tomography (DECT) in patients with gouty arthritis.</p> </section> <section> <h3> Methods</h3> <p>A total of 160 patients with gouty arthritis who were treated in our hospital from January 2023 to October 2023 were selected as the research subjects. The participants were randomly divided into two groups: an observation group and a control group. Each group had 80 cases. Observation group performed DECT examination and control group performed X-ray examination. The researchers recorded the general information of the participants in both groups and conducted single-factor analysis. They compared the detection of positive diseased joints between the two groups, as well as compared the distribution of positive diseased joints. In addition, the number of joint lesions was compared in the two groups.</p> </section> <section> <h3> Results</h3> <p>There were not any statistically great differences between the two groups in gender, age, BMI, disease duration, blood uric acid, and erythrocyte sedimentation rate (<i>p</i> > 0.05). During the DECT examination, a total of 82 positive diseased joints were identified in the observation group. The observation group also had a positive rate of 85.42% (82/96) in the DECT examination. While the control group had a total of 55 positive diseased joints during the X-ray examination with a positive rate of 59.78% (55/92). The difference between the two groups of patients in the positive rate of two kinds of examination was statistically significant (<i>χ</i><sup>2</sup> = 15.616, <i>p</i> < 0.001). No statistical significance was found in the distribution of the number of positive diseased joints between two groups (<i>χ</i><sup>2</sup> = 1.986, <i>p</i> = 0.851). Both DECT and X-ray examinations of patients in the two groups revealed that the lesions were primarily located in the soft tissues or ligaments surrounding the distal small joints of the limbs, such as metatarsophalangeal joints, ankle joints, and proximal interphalangeal joints. Compared with the X-ray examination of the patients, the DECT examination of the patients showed a great increase in the number of bone destruction, gout nodules, and soft tissue swelling (<i>χ</i><sup>2</sup> = 7.712, 10.441, 5.389, <i>p</i> = 0.005, 0.001, 0.020). Moreover, the DECT examination of patients showed the presence of urate crystals and joint effusion, while the X-ray examination of patients in the control group did not show any.</p> </section> <section> <h3> Conclusions</h3>
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引用次数: 0
Transparent and Reproducible Research Practices in Rheumatology: Protocol for A 20-Year Longitudinal Analysis
IF 2.4 4区 医学 Q2 RHEUMATOLOGY Pub Date : 2024-11-29 DOI: 10.1111/1756-185X.15429
Chak Kwan Cheung, Hugo W. F. Mak, Julio Lau, Shirley C. W. Chan, Philip H. Li
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引用次数: 0
Does Extended Vascular Screening Be Performed in All Asymptomatic Behçet's Disease Patients With Previously Diagnosed Vascular Involvement or Unexplained Inflammatory Response?
IF 2.4 4区 医学 Q2 RHEUMATOLOGY Pub Date : 2024-11-29 DOI: 10.1111/1756-185X.15435
Haner Direskeneli, Kerem Yiğit Abacar, Fatma Alibaz-Oner
<p>Behçet's disease (BD) usually start with mucocutaneous symptoms such as orogenital ulcers and later on develop ocular, vascular, gastrointestinal, and neurological manifestations [<span>1</span>]. Oral ulcers are the first manifestation in up to two thirds, whereas ocular manifestations (~50%) are usually observed in the first few years and vascular disease in 5–10 years of follow-up [<span>2, 3</span>]. However, as major organ manifestations can be the first manifestation without orogenital ulcers, the hallmark of the disease, diagnosis can be delayed [<span>4</span>]. Recently, efforts to increase diagnostic tools in BD has shown “femoral vein wall assessment” with Doppler US as a useful diagnostic test for BD [<span>5</span>].</p><p>Disease monitoring in early Behçet's disease is usually limited to multi-systemic assessment of symptoms or signs with laboratory tests to detect systemic inflammation (with routinely available acute-phase reactant biomarkers C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR)) or necessary for drug monitorization. As most patients with early disease has mainly mucocutaneous manifestations, this approach is usually sufficient. However, in centers experienced in severe BD and working with ethnicities with a high-risk of major organ involvement, all patients are seen by ophthalmologists for early asymptomatic disease. In a recent study, Uçar et al. observed that BD patients without uveitis but with cellular debris in the anterior vitreous have a higher risk of clinically significant ocular disease (22% vs. 1%) during follow-up [<span>6</span>]. Therefore, subclinical ocular findings might have prognostic implications in patients with BD screened for ocular involvement.</p><p>Vascular disease in BD is reported to be 15%–50% in different series with the highest prevalence around the Mediterranean basin [<span>2, 3, 7</span>]. In addition to genetic factors, follow-up of patients in different specialties such as dermatology or ophthalmology can also explain different prevalences, as guidelines for systemic disease monitoring is not established.</p><p>Vascular disease in BD has characteristics of a variable-vessel vasculitis involving both venous and arterial systems [<span>2, 8</span>]. Patients are usually young males in the third/fourth decades and present most frequently (up to 70%) with superficial thrombophlebitis or deep vein thrombosis of the lower extremities (DVT) [<span>9, 10</span>]. Any male, physically active young patient presenting with DVT without traditional risk factors (immobility, surgery, etc.) should lead an experienced clinician to a search for the diagnosis of BD, at least in regions with a high prevalence of vascular-BD. About 10% of the cases with a further diagnosis of BD can have a vascular event as the first manifestation without mucocutaneous features [<span>10</span>]. In patients without immune-suppressive treatment after the first attack, relapses are observed in up to 5
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引用次数: 0
The Modern Epidemic of Autoimmunity 现代自体免疫流行病
IF 2.4 4区 医学 Q2 RHEUMATOLOGY Pub Date : 2024-11-25 DOI: 10.1111/1756-185X.15426
Jie-Fu Zheng, Yung-Heng Lee, Pui-Ying Leong

Autoimmunity occurs when the immune system mistakenly attacks the body, but the presence of autoantibodies, such as antinuclear antibodies (ANAs), does not always lead to autoimmune diseases. Globally, autoimmunity is on the rise, influenced by socioeconomic factors, environmental exposure, diet, and stress. Climate change and pollution further exacerbate risks. The COVID-19 pandemic has worsened the issue, with unvaccinated individuals showing higher rates of autoimmune conditions postinfection. Preventive strategies, including healthy diets, stress management, and vaccination, are crucial in combating this growing epidemic. Collaboration between individuals, healthcare providers, and policymakers is critical to mitigate the rise in autoimmune disorders and enhance public health.

自身免疫是指免疫系统错误地攻击人体,但自身抗体(如抗核抗体(ANA))的存在并不一定会导致自身免疫性疾病。在全球范围内,受社会经济因素、环境暴露、饮食和压力的影响,自身免疫性疾病呈上升趋势。气候变化和污染进一步加剧了风险。COVID-19 大流行使这一问题更加严重,未接种疫苗的人在感染后出现自身免疫疾病的比例更高。包括健康饮食、压力管理和疫苗接种在内的预防策略对于应对这一日益严重的流行病至关重要。个人、医疗保健提供者和政策制定者之间的合作对于缓解自身免疫性疾病的增加和提高公共卫生水平至关重要。
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引用次数: 0
Anasarca and Systemic Capillary Leak Syndrome as an Unusual Presentation of Juvenile Dermatomyositis: Report of Three Cases and Case-Based Review 作为幼年皮肌炎一种罕见表现的水肿和全身毛细血管渗漏综合征:三个病例的报告和基于病例的综述
IF 2.4 4区 医学 Q2 RHEUMATOLOGY Pub Date : 2024-11-24 DOI: 10.1111/1756-185X.15425
Srinivasavaradan Govindarajan, Aswani Rajan, Puttashankariah Likhitha, Shivaprasad Pannasamudra Mohankumar, Pragati Jain, Manisha Jana, Narendra Kumar Bagri, Pankaj Hari, Rakesh Lodha
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引用次数: 0
Iatrogenic Cushing's Syndrome With Lipid Deposition in Spinal Canal 伴有椎管脂质沉积的先天性库欣综合征
IF 2.4 4区 医学 Q2 RHEUMATOLOGY Pub Date : 2024-11-24 DOI: 10.1111/1756-185X.15424
Yong Chen, Cai-Lin Li, Yan-Juan Chen, Juan Chen
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引用次数: 0
Exploring Health-Related Quality of Life in Brazilian Patients With Idiopathic Inflammatory Myopathies 探索巴西特发性炎症性肌病患者与健康相关的生活质量
IF 2.4 4区 医学 Q2 RHEUMATOLOGY Pub Date : 2024-11-24 DOI: 10.1111/1756-185X.15423
Letícia Queiroga de Figueiredo, Rafael Alves Cordeiro, Samuel Katsuyuki Shinjo
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引用次数: 0
Scavenger receptor-A is a sensitive disease activity biomarker in ESR and CRP normal rheumatoid arthritis 清道夫受体-A 是 ESR 和 CRP 正常类风湿性关节炎的敏感疾病活动生物标志物。
IF 2.4 4区 医学 Q2 RHEUMATOLOGY Pub Date : 2024-11-22 DOI: 10.1111/1756-185X.15404
Shixiong Cao, Xu Liu, Yang Xie, Fanlei Hu, Zhanguo Li, Yin Su, Li Luo, Xiaolin Sun

Objective

Identification of rheumatoid arthritis (RA) patients in active disease with normal ESR and CRP is a challenge in disease activity assessment. The objective of this study was to evaluate the performance and clinical significance of Scavenger receptor-A (SRA) as a disease activity biomarker in RA, especially in ESR and CRP normal patients.

Methods

One hundred and sixty-two RA (40 discovery cohort; 122 validation cohort), 20 osteoarthritis (OA), and 36 healthy controls (HCs) were recruited. Ten disease activity markers were evaluated by Bio-Plex Pro Human Cytokine Assay in the discovery cohort. SRA levels were measured by enzyme-linked immunosorbent assay (ELISA) in the validation cohort. The association between SRA and clinical phenotypes was also analyzed. ROC analysis was performed for disease activity prediction.

Results

SRA was found to be correlated with disease activity in the discovery cohort. The serum SRA level was verified by ELISA in the validation cohort, and was found to be correlated with disease activity index in RA patients, including DAS28-ESR (r = .477, p < .001), swollen joint counts, and tender joint counts; as well as inflammation markers, including ESR and CRP. In ESR and CRP normal RA, there was a strong correlation between SRA and DAS28-ESR (χ2$$ {chi}^2 $$ = 4.564, p = .003). In addition, area under the ROC of SRA was higher than AUCESR and AUCCRP in ESR and CRP normal RA patients, suggesting that serum SRA could be more sensitive than ESR and CRP for disease activity assessment in this group of patients. In the low DAS28-ESR (≤3.2) group, the AUC of SRA for disease activity measurement was higher than that of ESR and CRP, indicating that SRA was also more sensitive than ESR and CRP in low-disease activity RA.

Conclusion

SRA was correlated with RA disease activity and may be a sensitive serum biomarker for disease activity evaluation, especially in ESR and CRP normal patients, as well as in the low-disease activity group. SRA could be a promising marker for disease activity assessment.

目的:类风湿关节炎(RA)患者的血沉(ESR)和血清反应蛋白(CRP)正常但疾病处于活动期,如何鉴别这些患者是疾病活动性评估的一项挑战。本研究旨在评估清道夫受体-A(SRA)作为类风湿关节炎疾病活动性生物标志物的性能和临床意义,尤其是在血沉和 CRP 正常的患者中:招募了 162 名 RA(40 名发现队列;122 名验证队列)、20 名骨关节炎(OA)和 36 名健康对照(HC)。在发现队列中,用 Bio-Plex Pro 人类细胞因子测定法评估了 10 种疾病活动性标志物。在验证队列中,通过酶联免疫吸附试验(ELISA)测量了 SRA 水平。此外,还分析了 SRA 与临床表型之间的关联。对疾病活动性预测进行了 ROC 分析:结果:在发现队列中发现 SRA 与疾病活动性相关。在验证队列中,血清SRA水平经ELISA验证,发现与RA患者的疾病活动指数相关,包括DAS28-ESR(r = .477,p χ 2 $$ {chi}^2 $$ = 4.564,p = .003)。此外,在血沉和CRP正常的RA患者中,SRA的ROC下面积高于AUCESR和AUCCRP,这表明血清SRA比血沉和CRP对该组患者的疾病活动性评估更敏感。在低DAS28-ESR(≤3.2)组中,SRA对疾病活动性测量的AUC高于ESR和CRP,表明SRA对低疾病活动性RA的敏感性也高于ESR和CRP:结论:SRA与RA疾病活动性相关,可能是评估疾病活动性的敏感血清生物标记物,尤其是在血沉和CRP正常的患者以及低疾病活动性组中。SRA可能是一种有前途的疾病活动性评估标志物。
{"title":"Scavenger receptor-A is a sensitive disease activity biomarker in ESR and CRP normal rheumatoid arthritis","authors":"Shixiong Cao,&nbsp;Xu Liu,&nbsp;Yang Xie,&nbsp;Fanlei Hu,&nbsp;Zhanguo Li,&nbsp;Yin Su,&nbsp;Li Luo,&nbsp;Xiaolin Sun","doi":"10.1111/1756-185X.15404","DOIUrl":"10.1111/1756-185X.15404","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Identification of rheumatoid arthritis (RA) patients in active disease with normal ESR and CRP is a challenge in disease activity assessment. The objective of this study was to evaluate the performance and clinical significance of Scavenger receptor-A (SRA) as a disease activity biomarker in RA, especially in ESR and CRP normal patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>One hundred and sixty-two RA (40 discovery cohort; 122 validation cohort), 20 osteoarthritis (OA), and 36 healthy controls (HCs) were recruited. Ten disease activity markers were evaluated by Bio-Plex Pro Human Cytokine Assay in the discovery cohort. SRA levels were measured by enzyme-linked immunosorbent assay (ELISA) in the validation cohort. The association between SRA and clinical phenotypes was also analyzed. ROC analysis was performed for disease activity prediction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>SRA was found to be correlated with disease activity in the discovery cohort. The serum SRA level was verified by ELISA in the validation cohort, and was found to be correlated with disease activity index in RA patients, including DAS28-ESR (<i>r</i> = .477, <i>p</i> &lt; .001), swollen joint counts, and tender joint counts; as well as inflammation markers, including ESR and CRP. In ESR and CRP normal RA, there was a strong correlation between SRA and DAS28-ESR (<span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <msup>\u0000 <mi>χ</mi>\u0000 <mn>2</mn>\u0000 </msup>\u0000 </mrow>\u0000 <annotation>$$ {chi}^2 $$</annotation>\u0000 </semantics></math> = 4.564, <i>p</i> = .003). In addition, area under the ROC of SRA was higher than AUC<sub>ESR</sub> and AUC<sub>CRP</sub> in ESR and CRP normal RA patients, suggesting that serum SRA could be more sensitive than ESR and CRP for disease activity assessment in this group of patients. In the low DAS28-ESR (≤3.2) group, the AUC of SRA for disease activity measurement was higher than that of ESR and CRP, indicating that SRA was also more sensitive than ESR and CRP in low-disease activity RA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SRA was correlated with RA disease activity and may be a sensitive serum biomarker for disease activity evaluation, especially in ESR and CRP normal patients, as well as in the low-disease activity group. SRA could be a promising marker for disease activity assessment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Report: ISG15 Deficiency and a Glimpse Into Autoimmunity 病例报告:ISG15 缺乏症与自身免疫一瞥
IF 2.4 4区 医学 Q2 RHEUMATOLOGY Pub Date : 2024-11-22 DOI: 10.1111/1756-185X.15420
Lujayn Akbar, Bashayer Alawam, Meshal Alhassan, Sarah Yousef Faisal, Mohammed Ahmed Al-Omari, Sulaiman Mohammed Al-Mayouf
{"title":"Case Report: ISG15 Deficiency and a Glimpse Into Autoimmunity","authors":"Lujayn Akbar,&nbsp;Bashayer Alawam,&nbsp;Meshal Alhassan,&nbsp;Sarah Yousef Faisal,&nbsp;Mohammed Ahmed Al-Omari,&nbsp;Sulaiman Mohammed Al-Mayouf","doi":"10.1111/1756-185X.15420","DOIUrl":"https://doi.org/10.1111/1756-185X.15420","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of an Osteoporosis Refracture Prevention Program—A Comparison of Two Australian Rural Centers Using Population Database Linkage 骨质疏松症骨折预防计划的效果--利用人口数据库链接对澳大利亚两个农村中心进行的比较
IF 2.4 4区 医学 Q2 RHEUMATOLOGY Pub Date : 2024-11-19 DOI: 10.1111/1756-185X.15421
Peter K. K. Wong, Aedan Roberts, Tracey Ho, Sandy Fraser, Julia Thompson, Jennifer Williamson, Elizabeth Hay
{"title":"The Effect of an Osteoporosis Refracture Prevention Program—A Comparison of Two Australian Rural Centers Using Population Database Linkage","authors":"Peter K. K. Wong,&nbsp;Aedan Roberts,&nbsp;Tracey Ho,&nbsp;Sandy Fraser,&nbsp;Julia Thompson,&nbsp;Jennifer Williamson,&nbsp;Elizabeth Hay","doi":"10.1111/1756-185X.15421","DOIUrl":"https://doi.org/10.1111/1756-185X.15421","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"27 11","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International Journal of Rheumatic Diseases
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