International Journal of Rheumatic Diseases最新文献

{"title":"DRESSed for Relapse: A Rare Case of Leflunomide-Induced DRESS With Hepatic Complications","authors":"Kajal Patel, Pooja Jotwani, Marie-Claire Maroun","doi":"10.1111/1756-185x.70560","DOIUrl":"10.1111/1756-185x.70560","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146063582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Radiographic Factors Associated With Difficult-to-Manage Axial Spondyloarthritis: A Multicenter Study","authors":"Haluk Cinakli,&nbsp;Mete Kara,&nbsp;Gülay Alp","doi":"10.1111/1756-185x.70558","DOIUrl":"10.1111/1756-185x.70558","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the clinical characteristics, disease burden, and treatment patterns of axial spondyloarthritis (axSpA) using the recently proposed Assessment of Spondyloarthritis International Society (ASAS) definition of difficult-to-manage axSpA (D2M-axSpA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 383 patients with axSpA were enrolled. This multicenter cross-sectional study was conducted in three tertiary care centers, enrolling consecutive axSpA patients from outpatient clinics. Patients were classified as D2M-axSpA based on prior use of biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) and persistent disease activity based on the ASAS definition. Logistic regression analysis identified factors associated with D2M-axSpA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among patients, 11.2% met the D2M-axSpA criteria. The cohort was 58.7% male, with a mean age of 43.5 ± 10.5 years. Radiographic axSpA was present in 70.8%, and 69.2% of patients had received biological therapy. D2M-axSpA patients exhibited higher inflammatory markers (ESR, CRP), increased disease activity (BASDAI, ASDAS-CRP), and greater functional impairment (BASFI, ASQoL). Peripheral arthritis (<i>p</i> = 0.001), enthesitis (<i>p</i> = 0.031), smoking history (<i>p</i> = 0.037), and comorbidities (<i>p</i> = 0.020) were significantly more frequent in D2M-axSpA. Among D2M-axSpA patients, 22/383 (5.7%) fulfilled the treatment-refractory criteria. Radiographic findings revealed higher rates of sacroiliac ankylosis, lumbar syndesmophytes, symphysitis, and ischial enthesitis, as well as mSASSS scores. Logistic regression identified anterior uveitis (OR: 4.474, <i>p</i> = 0.007), peripheral arthritis (OR: 2.684, <i>p</i> = 0.021), and comorbidities (OR: 2.878, <i>p</i> = 0.013) as independently associated factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Findings highlight the clinical and radiographic burden of D2M-axSpA and emphasize the need for optimized treatment strategies, particularly in patients with comorbidities, a history of anterior uveitis or peripheral arthritis, and those with a smoking history.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146063490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Immune Cells and Plasma Metabolites on Osteoarthritis: A Mediation Mendelian Randomization Study","authors":"Changfa Huang,&nbsp;Hao Fan,&nbsp;Zhifa Zheng,&nbsp;Wenjing Ma,&nbsp;Ze Wei,&nbsp;Huitian Han,&nbsp;Annan Liang,&nbsp;Xuemeng Mu,&nbsp;Wei Zou,&nbsp;Jing Hao,&nbsp;Fei Liu,&nbsp;Lijin Liu,&nbsp;Su Liu,&nbsp;Lina Zhao,&nbsp;Zhihong Wu","doi":"10.1111/1756-185x.70447","DOIUrl":"10.1111/1756-185x.70447","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Recent studies suggest that immune cells and plasma metabolites may play significant roles in osteoarthritis pathogenesis. However, the causal relationships between these factors and osteoarthritis are unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Based on the genome-wide association study (GWAS) database, 731 immune cell phenotypes and 1400 metabolites were evaluated for their possible mediating effects on osteoarthritis via two-step Mendelian randomization (MR). Sensitivity analyses were conducted to assess the robustness of our findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our findings revealed that 17 immune cell phenotypes were positively associated with osteoarthritis, suggesting their potential as risk factors. Conversely, 23 immune cell phenotypes exhibited a negative association, indicating possible protective roles against osteoarthritis. Furthermore, we identified 51 metabolites as potential risk factors for osteoarthritis. Conversely, 34 metabolites were deemed protective factors. Notably, 49 plasma metabolites partially mediated the relationship between 35 immune cell phenotypes and osteoarthritis, with leucine levels showing the highest mediation proportion (19.3%) between HLA DR+ CD4+ %lymphocytes and osteoarthritis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our study revealed a substantial impact of specific immune cell phenotypes and plasma metabolites on the progression of osteoarthritis, enhancing the understanding of the complex interplay between immunity and metabolism in osteoarthritis pathogenesis. Further research is necessary to clarify the underlying mechanisms driving these associations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146063604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Acquired Angioneurotic Edema With Massive Pericardial Effusion as the Harbinger of Systemic Lupus Erythematosus","authors":"Iwa Bhattarai,&nbsp;Neethu Ravi,&nbsp;Sarthak Chakrabarti,&nbsp;Yash Shrivastava,&nbsp;Prashant Kumar Verma","doi":"10.1111/1756-185x.70555","DOIUrl":"10.1111/1756-185x.70555","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Get OUT: Factors Associated With a Longer Length of Stay in Patients Admitted With an Acute Gout Flare, and the Effects of Anakinra on Length of Stay","authors":"Selin Cilli Hayıroğlu","doi":"10.1111/1756-185x.70556","DOIUrl":"10.1111/1756-185x.70556","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheumatoid Factor Levels Are Associated With Arthritis Exacerbation After Bucillamine Discontinuation","authors":"Yusuke Ogata,&nbsp;Masumi Bamba,&nbsp;Koichi Bamba,&nbsp;Ryo Hisada,&nbsp;Hiroyuki Nakamura","doi":"10.1111/1756-185x.70551","DOIUrl":"10.1111/1756-185x.70551","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Bucillamine is a conventional synthetic disease-modifying antirheumatic drug that can be used as a methotrexate alternative. However, which patients with rheumatoid arthritis can benefit from bucillamine treatment has not been established.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients who had taken bucillamine and discontinued it in 2021 due to a nationwide supply shortage were included in this study. We followed up these patients regarding arthritis exacerbation after bucillamine discontinuation until March 2025. Baseline clinical patient characteristics were compared between the exacerbation and non-exacerbation groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirteen of the 18 patients experienced arthritis exacerbation, whereas five remained exacerbation-free for up to 48 months. The baseline rheumatoid factor levels were significantly higher in the exacerbation group (49 U/mL) than in the non-exacerbation group (6 U/mL). Receiver operating characteristic and Kaplan–Meier analyses showed that baseline RF levels ≥ 28 U/mL predicted arthritis exacerbation after bucillamine discontinuation (sensitivity 76.2% and specificity 80.0%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Following bucillamine discontinuation, arthritis exacerbations occurred more frequently in patients with rheumatoid factor levels of 28 U/mL or higher, alongside an increase in these levels. Rheumatoid factor levels may serve as a useful biomarker for identifying patients who would benefit from continued bucillamine therapy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Comparative Effectiveness of TNFα and IL6 Inhibitors on Bone Health Outcomes and Mortality in Rheumatoid Arthritis Patients: A Retrospective Cohort Study”","authors":"","doi":"10.1111/1756-185x.70553","DOIUrl":"10.1111/1756-185x.70553","url":null,"abstract":"<p>Wang H. Lee Y. H. Cheng I.H. Wang S. I. Ji J. Huo A. P. Hung Y.M. 2025 Comparative Effectiveness of TNF-α and IL-6 Inhibitors on Bone Health Outcomes and Mortality in Rheumatoid Arthritis Patients: A Retrospective Cohort Study. International Journal of Rheumatic Diseases 28 6 e70204. 10.1111/1756-185X.70204.</p><p>The funding section in the above article is incorrect. The correct information is shown below.</p><p>\u0000 <b>Funding</b>\u0000 </p><p>This work was supported by funding from the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University (CSH-2024-E-001-Y2) and Zhejiang Provincial Natural Science Foundation of China (LGJ21H100001).</p><p>We apologize for this error.</p>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1756-185x.70553","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic Ultrasound-Guided Musculoskeletal Injections: The Next Frontier in Precision Medicine","authors":"Ahmad Jasem Abdulsalam,&nbsp;Renu Ambardar,&nbsp;Sarah Y. Alkandari","doi":"10.1111/1756-185x.70557","DOIUrl":"10.1111/1756-185x.70557","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Erythema and Induration of the Upper Arm in a Young Woman: What Is the Cause?","authors":"Susumu Tsunoda,&nbsp;Naoki Sawa","doi":"10.1111/1756-185x.70554","DOIUrl":"10.1111/1756-185x.70554","url":null,"abstract":"","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanics and Obesity in Osteoarthritis: From Mechanism to Precision Medicine","authors":"Shangqi Guan,&nbsp;Yifang Mei","doi":"10.1111/1756-185x.70539","DOIUrl":"10.1111/1756-185x.70539","url":null,"abstract":"<div>\u0000 \u0000 <p>Osteoarthritis (OA) is a degenerative joint disease driven by complex biomechanical and inflammatory mechanisms, particularly in weight-bearing joints such as the knee. This review explores the pivotal role of biomechanics in OA pathogenesis, focusing on abnormal joint loading, malalignment, and instability as key contributors to cartilage degeneration and subchondral bone remodeling. Special attention is given to the interplay between obesity and OA, highlighting how mechanical overload and adipokine-mediated inflammation synergistically accelerate disease progression. Emerging interventions—including physical therapy, gait retraining, orthotics, high tibial osteotomy (HTO), and total knee arthroplasty (TKA)—are analyzed for their biomechanical impact. Novel technologies such as wearable sensors, finite element analysis (FEA), and digital twin models are discussed as tools for real-time assessment, predictive modeling, and personalized treatment planning. The review emphasizes the need for integrated, multiscale research strategies that account for individual biomechanical profiles and systemic factors like obesity. Advancing biomechanical precision in OA management holds promise for improving early diagnosis, optimizing interventions, and informing regenerative therapies aimed at restoring joint function and delaying disease progression.</p>\u0000 </div>","PeriodicalId":14330,"journal":{"name":"International Journal of Rheumatic Diseases","volume":"29 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}