Pub Date : 2023-10-25DOI: 10.18203/issn.2455-4529.intjresdermatol20233176
Otarid Bashir Mohammed, Khalid Badreldin Fadl Alla
Background: Pityriasis versicolor is a fungal skin disease, chronic and superficial in the course, characterized by skin pigmentary changes that psychologically impact the patient's quality of life. This paper intended to determine the clinico-epidemiological pattern of the Pityriasis versicolor in patients who attended the outpatient clinic of Khartoum dermatology teaching hospital (KDTH) from June 2012 to February 2013. Method: This descriptive, analytical, cross-sectional hospital-based study used a quantitative method. A total convenient sample technique enrolled 110 patients during the study period. Results: The 30.9% of the participants were between 11 and 20 years old, 67.3% were males, and 37.1% were of low socioeconomic status, 47.2% had a family history of the disease, 68.1% had first-degree relatives, 56.4% and 60% had a history of a similar condition in the summer, respectively. 57.3% were originally from a pure Arab tribe, compared to 0.9% from purely African tribes. There were significant associations between being male with a positive family history, the onset of the disease, color of the lesions, and having disease (p=0.02, 0.05, 0.04, respectively). Also, between the age with a history of similar condition and the associated symptoms (p=0.00 and 0.03 respectively). Conclusions: Most participants were young males who had the disease in the summer with a high recurrence rate. There were multiple significant associations between gender and age with some clinical and epidemiological patterns. Determining any genetic association with pityriasis versicolor, improving counselling, and raising awareness to understand age the predisposing factors were recommended in this paper.
{"title":"Clinico-epidemiological pattern of pityriasis versicolor in Sudanese patients at Khartoum dermatology and venerology hospital, Khartoum State, Sudan, 2012-2013","authors":"Otarid Bashir Mohammed, Khalid Badreldin Fadl Alla","doi":"10.18203/issn.2455-4529.intjresdermatol20233176","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20233176","url":null,"abstract":"Background: Pityriasis versicolor is a fungal skin disease, chronic and superficial in the course, characterized by skin pigmentary changes that psychologically impact the patient's quality of life. This paper intended to determine the clinico-epidemiological pattern of the Pityriasis versicolor in patients who attended the outpatient clinic of Khartoum dermatology teaching hospital (KDTH) from June 2012 to February 2013. Method: This descriptive, analytical, cross-sectional hospital-based study used a quantitative method. A total convenient sample technique enrolled 110 patients during the study period. Results: The 30.9% of the participants were between 11 and 20 years old, 67.3% were males, and 37.1% were of low socioeconomic status, 47.2% had a family history of the disease, 68.1% had first-degree relatives, 56.4% and 60% had a history of a similar condition in the summer, respectively. 57.3% were originally from a pure Arab tribe, compared to 0.9% from purely African tribes. There were significant associations between being male with a positive family history, the onset of the disease, color of the lesions, and having disease (p=0.02, 0.05, 0.04, respectively). Also, between the age with a history of similar condition and the associated symptoms (p=0.00 and 0.03 respectively). Conclusions: Most participants were young males who had the disease in the summer with a high recurrence rate. There were multiple significant associations between gender and age with some clinical and epidemiological patterns. Determining any genetic association with pityriasis versicolor, improving counselling, and raising awareness to understand age the predisposing factors were recommended in this paper.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"36 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nevoid basal cell carcinoma syndrome, or basal cell nevus syndrome (Gorlin-Goltz syndrome), is a rare autosomal dominant inherited disorder which is characterized by multiple basal cell carcinomas from a young age. Other distinguishing clinical features that are seen in a majority of patients, includes keratocystic odontogenic tumors (formerly odontogenic keratocysts) and dyskeratotic palmar and plantar pitting. Estimated prevalence is 1 in 57,000 to 1 in 164,000. We report a case of this syndrome seen in a 43-year-old female patient with multiple black pigmented papules and plaques on face and trunk that first appeared when she was teenager. Her clinical features of were fitting within the criteria for the diagnosis of BCNS. Early diagnosis and treatment of this syndrome is important to reduce severity of complications including cutaneous and cerebral malignancy and oromaxillofacial deformation and destruction due to jaw cysts.
{"title":"Gorlin-Goltz syndrome: an uncommon case","authors":"Sonika Soni, Jolly Mertia, Deepak Mathur, Disha Jain","doi":"10.18203/issn.2455-4529.intjresdermatol20233184","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20233184","url":null,"abstract":"Nevoid basal cell carcinoma syndrome, or basal cell nevus syndrome (Gorlin-Goltz syndrome), is a rare autosomal dominant inherited disorder which is characterized by multiple basal cell carcinomas from a young age. Other distinguishing clinical features that are seen in a majority of patients, includes keratocystic odontogenic tumors (formerly odontogenic keratocysts) and dyskeratotic palmar and plantar pitting. Estimated prevalence is 1 in 57,000 to 1 in 164,000. We report a case of this syndrome seen in a 43-year-old female patient with multiple black pigmented papules and plaques on face and trunk that first appeared when she was teenager. Her clinical features of were fitting within the criteria for the diagnosis of BCNS. Early diagnosis and treatment of this syndrome is important to reduce severity of complications including cutaneous and cerebral malignancy and oromaxillofacial deformation and destruction due to jaw cysts.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-25DOI: 10.18203/issn.2455-4529.intjresdermatol20233182
Adithyan P., Revathy S.
Autoimmune connective tissue disorders represent polygenic clinical disorders that have heterogenous and overlapping clinical features. Lupus erythematosus (LE) is a connective tissue disorder that affects multiple organ systems with increased incidence among female population compared to males (9:1 F:M ratio). Skin is 2nd most frequent organ to be affected in LE after joints. Cutaneous lesions are a source of disability and on many occasions, an indicator of internal disease and these lesions may be specific to lupus/seen in other conditions as well. Correlation between clinical, histopathology, immunofluorescence, and serologic profiles (Anti-nuclear antibody) remains crucial as no single clinical feature or lab abnormality can confirm the diagnosis of LE. Treatment consists of sun protection, topical sunscreens, systemic steroids, antimalarials, immunosuppressives and biologicals. Effective treatment should be initiated at the earliest to prevent complications. Herein we report 4 cases of LE with varied presentation.
{"title":"Varied spectrum of lupus erythematosus: case series","authors":"Adithyan P., Revathy S.","doi":"10.18203/issn.2455-4529.intjresdermatol20233182","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20233182","url":null,"abstract":"Autoimmune connective tissue disorders represent polygenic clinical disorders that have heterogenous and overlapping clinical features. Lupus erythematosus (LE) is a connective tissue disorder that affects multiple organ systems with increased incidence among female population compared to males (9:1 F:M ratio). Skin is 2nd most frequent organ to be affected in LE after joints. Cutaneous lesions are a source of disability and on many occasions, an indicator of internal disease and these lesions may be specific to lupus/seen in other conditions as well. Correlation between clinical, histopathology, immunofluorescence, and serologic profiles (Anti-nuclear antibody) remains crucial as no single clinical feature or lab abnormality can confirm the diagnosis of LE. Treatment consists of sun protection, topical sunscreens, systemic steroids, antimalarials, immunosuppressives and biologicals. Effective treatment should be initiated at the earliest to prevent complications. Herein we report 4 cases of LE with varied presentation.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"4 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134974107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-25DOI: 10.18203/issn.2455-4529.intjresdermatol20233181
Shaik Naseema, Yannamani Supriya, Alekhya Kotha, P. Vidyasagar, Bikkasani P. Lakshmi Kishan Rao
Background: Dermatophytosis has acquired an epidemic-like magnitude at the present times. The prevalence of the dermatophytosis is reported to be as high as 61.5% in some parts of the country. Hence, to address the management of the situation, we therefore studied 30% salicylic acid as a peeling agent for the treatment of dermatophytosis. Methods: 40 patients (25 males & 15 females) having dermatophytosis with positive potassium hydroxide (KOH) mounts were enrolled and Salicylic acid 30% application was done over the lesions weekly upto 4 weeks, and then followed up weekly upto 4 weeks. Results: 5 patients were treatment-naive, and 30 was receiving antifungal treatment in the past 6 months. A total of 30(85%) patients had achieved clinical and microbiological cure 1 week after the last salicylic acid application. Clinically, the lesions appeared to have significantly resolved with reduction in hyperpigmentation and size of the lesions. 5 patients (15%) were still KOH-positive at the end of the study period and showed clinical activity; but these patients reported symptomatic improvement. Conclusions: 30% Salicylic acid both keratolytic and anti-inflammatory effects shows it’s effect on tinea, which prevent drug resistance and facilitating fast cure of superficial dermatophytoses. Salicylic acid peels can be used successfully as an adjuvant in the treatment of tinea infections and to enhance the activity of antimycotic drugs.
{"title":"Incorporating salicylic acid peel as an adjuvant in treatment of superficial dermatophytosis: a new therapeutic approach","authors":"Shaik Naseema, Yannamani Supriya, Alekhya Kotha, P. Vidyasagar, Bikkasani P. Lakshmi Kishan Rao","doi":"10.18203/issn.2455-4529.intjresdermatol20233181","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20233181","url":null,"abstract":"Background: Dermatophytosis has acquired an epidemic-like magnitude at the present times. The prevalence of the dermatophytosis is reported to be as high as 61.5% in some parts of the country. Hence, to address the management of the situation, we therefore studied 30% salicylic acid as a peeling agent for the treatment of dermatophytosis. Methods: 40 patients (25 males & 15 females) having dermatophytosis with positive potassium hydroxide (KOH) mounts were enrolled and Salicylic acid 30% application was done over the lesions weekly upto 4 weeks, and then followed up weekly upto 4 weeks. Results: 5 patients were treatment-naive, and 30 was receiving antifungal treatment in the past 6 months. A total of 30(85%) patients had achieved clinical and microbiological cure 1 week after the last salicylic acid application. Clinically, the lesions appeared to have significantly resolved with reduction in hyperpigmentation and size of the lesions. 5 patients (15%) were still KOH-positive at the end of the study period and showed clinical activity; but these patients reported symptomatic improvement. Conclusions: 30% Salicylic acid both keratolytic and anti-inflammatory effects shows it’s effect on tinea, which prevent drug resistance and facilitating fast cure of superficial dermatophytoses. Salicylic acid peels can be used successfully as an adjuvant in the treatment of tinea infections and to enhance the activity of antimycotic drugs.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135216846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Effective skin cleansing is vital for maintaining skin health and appearance. An ideal skin cleaner retains moisture, removes oils, sweat, and dirt without causing irritation or dehydration. This study was designed to evaluate the efficacy, safety, tolerability and usage trends of a gentle skin cleanser containing cetyl alcohol, stearyl alcohol and colloidal oatmeal for individuals having dry and sensitive skin. Methods: We conducted a retrospective review at 102 centres, focusing on individuals aged 18 to 65 years with atopic dermatitis and dry skin conditions who required the use of gentle skin cleanser. Total 568 cases were taken; 488 cases of dry and sensitive skin were further analysed over a 2-week study period. Results: Gentle skin cleanser exhibited significant reduction (p<0.0001) in skin dryness, itchiness and irritation by 4.42±1.92 (63.38%), 4.03±2.71 (49.38%) and 4.44±2.07 (65.58%) respectively in participants with dry skin and by 4.25±1.48 (58.49%), 3.26±3.22 (18.02%) and 4.42±1.56 (63.23%) in participants with sensitive skin after its regular usage. Participants provided positive feedback and expressed overall satisfaction with the study product. Conclusions: Skin cleanser was efficacious and well-tolerable in participants in providing moisturizing, soothing, exfoliating, and antioxidant effects making it a preferred primary choice for managing dry and sensitive skin. The cleanser effectively cleansed excess oil, dirt, dead cells, microorganisms, and sweat providing a gentle and mild experience, in daily skin care.
{"title":"Cetyl alcohol, stearyl alcohol and colloidal oatmeal-based gentle skin cleanser in management of dry and sensitive skin: a cross-sectional study","authors":"Sumit Gupta, Hemendra B. Shah, Praveen Bhardwaj, Aditya Holani, Charu Singh, Sachin Yadav, Rathish Nair, Krishnaprasad Korukonda","doi":"10.18203/issn.2455-4529.intjresdermatol20233179","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20233179","url":null,"abstract":"Background: Effective skin cleansing is vital for maintaining skin health and appearance. An ideal skin cleaner retains moisture, removes oils, sweat, and dirt without causing irritation or dehydration. This study was designed to evaluate the efficacy, safety, tolerability and usage trends of a gentle skin cleanser containing cetyl alcohol, stearyl alcohol and colloidal oatmeal for individuals having dry and sensitive skin. Methods: We conducted a retrospective review at 102 centres, focusing on individuals aged 18 to 65 years with atopic dermatitis and dry skin conditions who required the use of gentle skin cleanser. Total 568 cases were taken; 488 cases of dry and sensitive skin were further analysed over a 2-week study period. Results: Gentle skin cleanser exhibited significant reduction (p<0.0001) in skin dryness, itchiness and irritation by 4.42±1.92 (63.38%), 4.03±2.71 (49.38%) and 4.44±2.07 (65.58%) respectively in participants with dry skin and by 4.25±1.48 (58.49%), 3.26±3.22 (18.02%) and 4.42±1.56 (63.23%) in participants with sensitive skin after its regular usage. Participants provided positive feedback and expressed overall satisfaction with the study product. Conclusions: Skin cleanser was efficacious and well-tolerable in participants in providing moisturizing, soothing, exfoliating, and antioxidant effects making it a preferred primary choice for managing dry and sensitive skin. The cleanser effectively cleansed excess oil, dirt, dead cells, microorganisms, and sweat providing a gentle and mild experience, in daily skin care.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"13 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135219109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Hair damage is a widespread problem that affects people of all ages, genders, and hair types. It can be caused by a variety of factors, such as heat styling, chemical treatments, environmental factors, and genetics. The effects of hair damage can range from minor split ends and frizz to severe breakage, thinning, and hair loss. Hair damage can also affect the texture and appearance of the hair, causing it to become dull, dry, and difficult to manage. Methods: In the present study 6 natural black hair tresses were selected to evaluate the sensorial parameters such as detangling, combability, static, shine, softness, smoothness, and bounce at baseline and post 10 wash cycles with Mintop Shampoo (fortified with Procapil 1% and Redensyl 1%). Results: After 10 wash cycles with Mintop Shampoo, the mean score for detangling 3.33 (0.516), combability 4.00 (0.516), Static (Frizz) 3.67 (0.516), Shine 3.00 (0.000), Softness 3.00 (0.632), Smoothness 3.33 (0.516), Bounce 3.33 (0.516), maximum GF 99.17 (0.516) and Strain 44.24 (5.235). Conclusions: The study findings demonstrated that a significant improvement was observed in sensorial parameters such as detangling, combability, static (reduction), shine, softness, smoothness, bounce, tensile strength, and percentage elongation when compared to baseline or initial damaged state.
{"title":"Evaluation of sensory parameters and tensile strength on damaged hair after ten washes with Mintop shampoo: in vitro study","authors":"Monil Yogesh Neena Gala, Snehal Muchhala, Akhila Paspulate, Rahul Rathod, Krishna Veligandla, Biswajit Aich, Arti Sanghavi, Nilesh Guhe, Alok Ranjan Samal, Anup Choudhry, Bhavesh Kotak","doi":"10.18203/issn.2455-4529.intjresdermatol20233178","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20233178","url":null,"abstract":"Background: Hair damage is a widespread problem that affects people of all ages, genders, and hair types. It can be caused by a variety of factors, such as heat styling, chemical treatments, environmental factors, and genetics. The effects of hair damage can range from minor split ends and frizz to severe breakage, thinning, and hair loss. Hair damage can also affect the texture and appearance of the hair, causing it to become dull, dry, and difficult to manage. Methods: In the present study 6 natural black hair tresses were selected to evaluate the sensorial parameters such as detangling, combability, static, shine, softness, smoothness, and bounce at baseline and post 10 wash cycles with Mintop Shampoo (fortified with Procapil 1% and Redensyl 1%). Results: After 10 wash cycles with Mintop Shampoo, the mean score for detangling 3.33 (0.516), combability 4.00 (0.516), Static (Frizz) 3.67 (0.516), Shine 3.00 (0.000), Softness 3.00 (0.632), Smoothness 3.33 (0.516), Bounce 3.33 (0.516), maximum GF 99.17 (0.516) and Strain 44.24 (5.235). Conclusions: The study findings demonstrated that a significant improvement was observed in sensorial parameters such as detangling, combability, static (reduction), shine, softness, smoothness, bounce, tensile strength, and percentage elongation when compared to baseline or initial damaged state.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Atopic dermatitis is a chronic skin condition characterized by dry, itchy and inflamed skin. This study evaluated the complementary benefits efficacy and tolerability of emollient c containing Aloe vera, Wheat germ oil, tea tree extract, and honey in patients with dry skin conditions. Methods: Cross-sectional analysis for clinical cases with dry skin receiving moisturizing cream formulation was undertaken at 156 centres. 286 case records of atopic dermatitis receiving standard of care as cleansers, Topical corticosteroids, moisturizers were further analysed for improvement in skin dryness and itchiness. Results: Regular use of Emollient formulation containing aloe vera, wheat germ oil, tea tree extract, honey was further analysed along with safety assessment over 8 weeks of observation period. The mean age of the study participants was 36.58 years. There was significant change in VAS score for dryness (p-value< 0.01), itch (p-value <0.01) with Patient Global Assessed rating as good (64.23%) for effectiveness and ease of application. Mild stinging, mild burning and irritation was experienced by 5 (1.75%) patients. Conclusions: The aloe vera, wheat germ oil, tea tree extract, honey enriched emollient formulation was efficacious and well tolerable in study participants in providing moisturizing, antimicrobial, and anti-inflammatory effects making it a preferred complementary therapy for managing atopic dermatitis following the short course therapy with TCS as a pertinent clinical strategy to avoid the atopic flares in such cases.
{"title":"Aloe vera, wheat germ oil, tea tree extract and honey-based emollient cream in the management of atopic dermatitis: a post-hoc analysis","authors":"Anil Ganjoo, Sunil Shah, Kiran V. Godse, Shefali Porwal, Punam Caplash, Rickson Pereira, Rathish Nair, Krishnaprasad Korukonda","doi":"10.18203/issn.2455-4529.intjresdermatol20233180","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20233180","url":null,"abstract":"Background: Atopic dermatitis is a chronic skin condition characterized by dry, itchy and inflamed skin. This study evaluated the complementary benefits efficacy and tolerability of emollient c containing Aloe vera, Wheat germ oil, tea tree extract, and honey in patients with dry skin conditions. Methods: Cross-sectional analysis for clinical cases with dry skin receiving moisturizing cream formulation was undertaken at 156 centres. 286 case records of atopic dermatitis receiving standard of care as cleansers, Topical corticosteroids, moisturizers were further analysed for improvement in skin dryness and itchiness. Results: Regular use of Emollient formulation containing aloe vera, wheat germ oil, tea tree extract, honey was further analysed along with safety assessment over 8 weeks of observation period. The mean age of the study participants was 36.58 years. There was significant change in VAS score for dryness (p-value< 0.01), itch (p-value <0.01) with Patient Global Assessed rating as good (64.23%) for effectiveness and ease of application. Mild stinging, mild burning and irritation was experienced by 5 (1.75%) patients. Conclusions: The aloe vera, wheat germ oil, tea tree extract, honey enriched emollient formulation was efficacious and well tolerable in study participants in providing moisturizing, antimicrobial, and anti-inflammatory effects making it a preferred complementary therapy for managing atopic dermatitis following the short course therapy with TCS as a pertinent clinical strategy to avoid the atopic flares in such cases.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"10 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-25DOI: 10.18203/issn.2455-4529.intjresdermatol20233183
Pooja Agarwal, Snehal V. Chaudhari, Kalgi Baxi, Sabha Neazee, Sohini Soneji, Malhar J. Shah
Since its introduction in 1951, methotrexate (MTX) has been widely used as the primary anti-psoriatic agent. However, unsupervised dosing by patients or concurrent use of excessive nonsteroidal anti-inflammatory drugs (NSAIDs) can lead to toxicity. Gastrointestinal symptoms are the most commonly observed manifestations, followed by cutaneous toxicity. In this retrospective study conducted at a tertiary care center in Gujarat, data from patients admitted for MTX toxicity between April 2017 and December 2019 were analyzed. A detailed history, including dosage, duration, signs and symptoms, investigations, treatment, and outcomes, was collected and evaluated. The study included 12 hospitalized patients (aged 35-70 years) with MTX toxicity. Among them, 10 patients had psoriasis, 1 had psoriatic arthritis, and 1 had rheumatoid arthritis with discoid lupus erythematosus. Eleven patients had taken daily oral MTX for one week along with painkillers, while one patient had taken an unknown amount without undergoing any investigations. Mucosal ulceration was observed in all cases, and skin necrosis was seen in 2 patients. Hematological investigations revealed myelosuppression in all patients, with altered renal function in 1 patient. Leucovorin (15 mg/ml) was administered to all patients, resulting in improvement for 10 patients, but 2 patients experienced persistent myelosuppression and succumbed to the toxicity. This study emphasizes the importance of pre-treatment investigations, proper monitoring, and strict avoidance of self-administration when administering MTX. Additionally, the co-administration of drugs such as NSAIDs should be judiciously managed. Folinic acid has shown usefulness in cases of MTX toxicity and overdose. In summary, this study underscores the significance of careful administration and monitoring of MTX, along with the avoidance of self-dosing. It highlights the need for judicious use of co-administered medications, and emphasizes the utility of folinic acid in managing MTX toxicity and overdose.
{"title":"Methotrexate toxicity-an alarming bell!","authors":"Pooja Agarwal, Snehal V. Chaudhari, Kalgi Baxi, Sabha Neazee, Sohini Soneji, Malhar J. Shah","doi":"10.18203/issn.2455-4529.intjresdermatol20233183","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20233183","url":null,"abstract":"Since its introduction in 1951, methotrexate (MTX) has been widely used as the primary anti-psoriatic agent. However, unsupervised dosing by patients or concurrent use of excessive nonsteroidal anti-inflammatory drugs (NSAIDs) can lead to toxicity. Gastrointestinal symptoms are the most commonly observed manifestations, followed by cutaneous toxicity. In this retrospective study conducted at a tertiary care center in Gujarat, data from patients admitted for MTX toxicity between April 2017 and December 2019 were analyzed. A detailed history, including dosage, duration, signs and symptoms, investigations, treatment, and outcomes, was collected and evaluated. The study included 12 hospitalized patients (aged 35-70 years) with MTX toxicity. Among them, 10 patients had psoriasis, 1 had psoriatic arthritis, and 1 had rheumatoid arthritis with discoid lupus erythematosus. Eleven patients had taken daily oral MTX for one week along with painkillers, while one patient had taken an unknown amount without undergoing any investigations. Mucosal ulceration was observed in all cases, and skin necrosis was seen in 2 patients. Hematological investigations revealed myelosuppression in all patients, with altered renal function in 1 patient. Leucovorin (15 mg/ml) was administered to all patients, resulting in improvement for 10 patients, but 2 patients experienced persistent myelosuppression and succumbed to the toxicity. This study emphasizes the importance of pre-treatment investigations, proper monitoring, and strict avoidance of self-administration when administering MTX. Additionally, the co-administration of drugs such as NSAIDs should be judiciously managed. Folinic acid has shown usefulness in cases of MTX toxicity and overdose. In summary, this study underscores the significance of careful administration and monitoring of MTX, along with the avoidance of self-dosing. It highlights the need for judicious use of co-administered medications, and emphasizes the utility of folinic acid in managing MTX toxicity and overdose.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"13 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-25DOI: 10.18203/issn.2455-4529.intjresdermatol20233186
Adithyan Panchatsharam, Revathy Sundaramurthy
Since antiquity, people have been plagued by tuberculosis (TB), and its effects are likely older than recorded history. For many centuries, TB was the most significant human infection due to its devastating mortality and morbidity rates and global prevalence. In developed nations, there is less evidence of Mycobacterium tuberculosis infections as a result of improved socioeconomic status. In developing nations like India, it is still regarded as a significant cause of morbidity and mortality. Cutaneous TB occurs worldwide and it comprises only a small proportion of all cases of TB, but considering the high prevalence of TB in many developing countries like India these numbers become significant. Cutaneous TB is a form of extra pulmonary TB and is characterized by a spectrum of multiple distinct clinical and histopathological presentations. It is imperative that the treating dermatologist is aware of the varied manifestations of cutaneous TB which would significantly prevent the morbidity and complications. This review aims to discuss the epidemiology, clinical, histopathological features, diagnosis, differential diagnosis and treatment options, especially in the Indian context.
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Pub Date : 2023-10-25DOI: 10.18203/issn.2455-4529.intjresdermatol20233185
Ramesh M., Dinesh Hawelia, Gayatri Bharadwaj, Gautam Dethe, Biswajit Aich, Krishna C. Veligandla, Rahul Rathod, Bhavesh P. Kotak
Itraconazole (ITZ) is a commonly prescribed oral antifungal agent in India and has a low minimum inhibitory concentration when compared to other oral antifungals. However, clinicians have reported inconsistent clinical responses despite its high skin levels, which may be due to variations in pelletization parameters, which affect its bioavailability and serum levels. Conventional ITZ has a maximum bioavailability of 55%; however, this is unpredictable and inconsistent. In contrast, the novel ITZ formulation, super bioavailable ITZ (ITZ-SB), has targeted drug release in the small intestine, resulting in predictable serum levels with minimal interindividual variability. This makes it a potentially useful drug in treating recalcitrant dermatophytosis. This expert opinion highlights the benefits of novel ITZ-SB with the incorporation of SUBA® technology. The SUBA® technology improves the bioavailability of poorly soluble drugs by ‘solid dispersion’ in polymer to increase drug absorbency. This technology also has potential to reduce variability in absorption and adverse effects. Benefits of this technology include more predictable clinical response and lower drug quantities necessary to achieve therapeutic blood levels, making it a promising treatment option for recalcitrant dermatophytosis. Fixtral SB, which uses this technology, is a novel weapon in the arsenal of treatments for superficial mycoses.
{"title":"Efficacy of super bioavailable itraconazole in the management of dermatophytosis in India","authors":"Ramesh M., Dinesh Hawelia, Gayatri Bharadwaj, Gautam Dethe, Biswajit Aich, Krishna C. Veligandla, Rahul Rathod, Bhavesh P. Kotak","doi":"10.18203/issn.2455-4529.intjresdermatol20233185","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20233185","url":null,"abstract":"Itraconazole (ITZ) is a commonly prescribed oral antifungal agent in India and has a low minimum inhibitory concentration when compared to other oral antifungals. However, clinicians have reported inconsistent clinical responses despite its high skin levels, which may be due to variations in pelletization parameters, which affect its bioavailability and serum levels. Conventional ITZ has a maximum bioavailability of 55%; however, this is unpredictable and inconsistent. In contrast, the novel ITZ formulation, super bioavailable ITZ (ITZ-SB), has targeted drug release in the small intestine, resulting in predictable serum levels with minimal interindividual variability. This makes it a potentially useful drug in treating recalcitrant dermatophytosis. This expert opinion highlights the benefits of novel ITZ-SB with the incorporation of SUBA® technology. The SUBA® technology improves the bioavailability of poorly soluble drugs by ‘solid dispersion’ in polymer to increase drug absorbency. This technology also has potential to reduce variability in absorption and adverse effects. Benefits of this technology include more predictable clinical response and lower drug quantities necessary to achieve therapeutic blood levels, making it a promising treatment option for recalcitrant dermatophytosis. Fixtral SB, which uses this technology, is a novel weapon in the arsenal of treatments for superficial mycoses.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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