Pub Date : 2023-04-27DOI: 10.18203/issn.2455-4529.intjresdermatol20231173
K. Joshi, A. Kalambe, A. Jadhav, Supria Mana
Acne is the inflammatory response of increased levels of hormones. Generally seen on the face as well as back, characterized by pimples, black heads, white heads and pustules. It may get severe if remains untreated. Acne directly correlates with the psychological conditions such as low self confidence to socialize, low self esteem, etc. Acne is most common in citizens thriving in central and peninsular regions of India especially teenagers. Spinach is found to be rich in antioxidants. This review was designed to generalize the use of spinach which is rich in flavonoids, phenolic acids, tocopherol; to determine its antioxidant properties as a herbal therapy for the developing stages of acne incorporating topical use; As a staple vegetable of the Indian diet, spinach can be exploited for its anti oxidant properties in the prophylaxis of acne. The review also involves, detailed information regarding the pathophysiology, receptors as well as the effect of acne on the patient’s mentality.
{"title":"A comprehensive review of herbal treatment of the species of spinach over the stages of acne vulgaris for research methodologies","authors":"K. Joshi, A. Kalambe, A. Jadhav, Supria Mana","doi":"10.18203/issn.2455-4529.intjresdermatol20231173","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231173","url":null,"abstract":"Acne is the inflammatory response of increased levels of hormones. Generally seen on the face as well as back, characterized by pimples, black heads, white heads and pustules. It may get severe if remains untreated. Acne directly correlates with the psychological conditions such as low self confidence to socialize, low self esteem, etc. Acne is most common in citizens thriving in central and peninsular regions of India especially teenagers. Spinach is found to be rich in antioxidants. This review was designed to generalize the use of spinach which is rich in flavonoids, phenolic acids, tocopherol; to determine its antioxidant properties as a herbal therapy for the developing stages of acne incorporating topical use; As a staple vegetable of the Indian diet, spinach can be exploited for its anti oxidant properties in the prophylaxis of acne. The review also involves, detailed information regarding the pathophysiology, receptors as well as the effect of acne on the patient’s mentality.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81777617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.18203/issn.2455-4529.intjresdermatol20231161
N. Agrawal, Tirtha Raj Saha, J. Barua, Gautam Banerjee, Kingshuk Chatterjee, S. Halder, Prabal Samanta
Background: Accurate diagnosis of leprosy is of paramount importance, because delays and misdiagnosis are more common in non-endemic zones. It has a long incubation period, varied clinical presentations, and reaction states which can present in any point of lifetime, becoming more challenging for proper management of this enigmatous disease. Methods: This was conducted as an institution based cross- sectional study over a period of 12 months. 100 patients were selected. Inclusion and exclusion criteria were maintained. Data collected was checked, tabulated, statistically analysed and compared with existing literature. Results: In our study, majority, 49% belonged in age group of 41-60 yrs, only 6% were less than 20 years old. Male: female ratio was 3.34. 62% were from rural areas. Family history of Hansen was present in 5%. 6% had Histoid while 5% had pure neuritic representing least common subtypes. Most common occupations were Housewives (19%), shopkeepers (16%) and office workers (16%). 59% presented with hypoesthesia, 28% with fever. 59% belonged to borderline, 27% belonged to polar spectrum. Trophic ulcers were found in 20%, clawing of digits in 27%. Conclusions: Leprosy is still a pressing problem in our country. A considerable number of children and adolescents get affected indicating high rate of transmission in community. A comprehensive approach includes proper diagnosis, treatment, and identification of reaction patterns, prevention of disability and deformities, and implementation of rehabilitation measures.
{"title":"Clinico-epidemiological study of leprosy in a tertiary care hospital of Eastern India","authors":"N. Agrawal, Tirtha Raj Saha, J. Barua, Gautam Banerjee, Kingshuk Chatterjee, S. Halder, Prabal Samanta","doi":"10.18203/issn.2455-4529.intjresdermatol20231161","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231161","url":null,"abstract":"Background: Accurate diagnosis of leprosy is of paramount importance, because delays and misdiagnosis are more common in non-endemic zones. It has a long incubation period, varied clinical presentations, and reaction states which can present in any point of lifetime, becoming more challenging for proper management of this enigmatous disease.\u0000Methods: This was conducted as an institution based cross- sectional study over a period of 12 months. 100 patients were selected. Inclusion and exclusion criteria were maintained. Data collected was checked, tabulated, statistically analysed and compared with existing literature.\u0000Results: In our study, majority, 49% belonged in age group of 41-60 yrs, only 6% were less than 20 years old. Male: female ratio was 3.34. 62% were from rural areas. Family history of Hansen was present in 5%. 6% had Histoid while 5% had pure neuritic representing least common subtypes. Most common occupations were Housewives (19%), shopkeepers (16%) and office workers (16%). 59% presented with hypoesthesia, 28% with fever. 59% belonged to borderline, 27% belonged to polar spectrum. Trophic ulcers were found in 20%, clawing of digits in 27%.\u0000Conclusions: Leprosy is still a pressing problem in our country. A considerable number of children and adolescents get affected indicating high rate of transmission in community. A comprehensive approach includes proper diagnosis, treatment, and identification of reaction patterns, prevention of disability and deformities, and implementation of rehabilitation measures.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78587356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.18203/issn.2455-4529.intjresdermatol20231165
P. Reddy, Maryam Maqsood
Tinea incognito refers to a type of dermatophyte infection that affects the skin, and its signs and symptoms upon presentation tend to appear permutated due to the prior use of immunosuppressants, corticosteroids or calcineurin inhibitors. We present a 42-year-old Asian (Indian) male patient with scaly erythematous rashes, mimicking annular erythema, and developing post-corticosteroid usage after an elective hair transplant procedure. The results of the biopsy reported that erythema annulare centrifugum (EAC) was absent, and the sample was suggestive of potential infective folliculitis. By day 3 of the presentation, with fungal stain tested positive for the presence of fungal infection. Based on this, the final diagnosis of tinea incognito was made. The final treatment prescribed for tinea incognito was an anti-fungal tablet of Itraconazole at a dose of 100 mg twice a day for 4 weeks, topical luliconazole, ciclopirox and anti-histamines for itching. Topical corticosteroids can change the clinical appearance of tinea by reducing erythema and scaling while enabling the fungus to grow freely without presenting the typical clinical indications of tinea. Practitioners should follow patients on corticosteroid treatment to alert them to potential cutaneous problems due to possible fungal infections, whenever warranted.
{"title":"Encountering steroid treatment induced tinea incognito: a case report","authors":"P. Reddy, Maryam Maqsood","doi":"10.18203/issn.2455-4529.intjresdermatol20231165","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231165","url":null,"abstract":"Tinea incognito refers to a type of dermatophyte infection that affects the skin, and its signs and symptoms upon presentation tend to appear permutated due to the prior use of immunosuppressants, corticosteroids or calcineurin inhibitors. We present a 42-year-old Asian (Indian) male patient with scaly erythematous rashes, mimicking annular erythema, and developing post-corticosteroid usage after an elective hair transplant procedure. The results of the biopsy reported that erythema annulare centrifugum (EAC) was absent, and the sample was suggestive of potential infective folliculitis. By day 3 of the presentation, with fungal stain tested positive for the presence of fungal infection. Based on this, the final diagnosis of tinea incognito was made. The final treatment prescribed for tinea incognito was an anti-fungal tablet of Itraconazole at a dose of 100 mg twice a day for 4 weeks, topical luliconazole, ciclopirox and anti-histamines for itching. Topical corticosteroids can change the clinical appearance of tinea by reducing erythema and scaling while enabling the fungus to grow freely without presenting the typical clinical indications of tinea. Practitioners should follow patients on corticosteroid treatment to alert them to potential cutaneous problems due to possible fungal infections, whenever warranted.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81087002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.18203/issn.2455-4529.intjresdermatol20231172
S. Alenazi, Mutaib A. Altamimi
Alopecia areata (AA) is a long-term autoimmune condition characterized by patchy, non-scarring hair loss. It involves an autoimmune inflammatory process that gives immunity privilege to some hair follicles, while subsequent inflammatory attacks target previously normal hair follicles. One of the most important discoveries in the pathogenesis of this disease is the Janus kinase (JAK)-signal transducer and activator of the transcription (STAT) pathway. Now that a greater understanding of the immunological processes contributing to the pathogenesis has been gained, current trials’ focus was on managing the immunological reaction involved in this disease. Baricitinib is a new first-generation JAK inhibitor that has been studied in multiple trials. This study's objectives were to review existing research and summarize information on the use of Baricitinib to treat AA. The Medline database was searched for relevant published research papers using variations of the following keywords: “AA,” “Baricitinib,” and “JAK inhibitors.” The search covered studies published from 2010–2022. Our findings showed that baricitinib’s use for severe AA in multiple studies generally led to improvement of patients’ conditions with minimal side effects.
{"title":"Review of efficacy of baricitinib in the treatment of alopecia areata","authors":"S. Alenazi, Mutaib A. Altamimi","doi":"10.18203/issn.2455-4529.intjresdermatol20231172","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231172","url":null,"abstract":"Alopecia areata (AA) is a long-term autoimmune condition characterized by patchy, non-scarring hair loss. It involves an autoimmune inflammatory process that gives immunity privilege to some hair follicles, while subsequent inflammatory attacks target previously normal hair follicles. One of the most important discoveries in the pathogenesis of this disease is the Janus kinase (JAK)-signal transducer and activator of the transcription (STAT) pathway. Now that a greater understanding of the immunological processes contributing to the pathogenesis has been gained, current trials’ focus was on managing the immunological reaction involved in this disease. Baricitinib is a new first-generation JAK inhibitor that has been studied in multiple trials. This study's objectives were to review existing research and summarize information on the use of Baricitinib to treat AA. The Medline database was searched for relevant published research papers using variations of the following keywords: “AA,” “Baricitinib,” and “JAK inhibitors.” The search covered studies published from 2010–2022. Our findings showed that baricitinib’s use for severe AA in multiple studies generally led to improvement of patients’ conditions with minimal side effects.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76311176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.18203/issn.2455-4529.intjresdermatol20231162
F. Sameem, Samia Aleem, Sumaiya Majeed, Aaqib Aslam, Seerat Fatima, S. Manzoor
Background: Various rheumatic disorders have cutaneous manifestations which sometimes precede systemic symptoms. These manifestations, therefore can act as diagnostic and prognostic markers of the rheumatic disorders. Understanding them may lead to early diagnosis, prompt treatment, and hence lower morbidity and mortality of the affected persons. The aims and objectives were to study the pattern of dermatological manifestations among patients of rheumatic disorders at a tertiary care centre from Kashmir valley in North India. Methods: Prospective observational study carried out in the department of Dermatology at SKIMS medical college in Kashmir valley in north India over a span of 12 months from July 2021 to June 2022. A sample size of 100 native Kashmiri patients of rheumatic disorders presenting to OPD with dermatological manifestations were included in the study. A detailed dermatological examination and history was taken. The various demographic data sought included age, gender, occupation, residence and clinical diagnosis. Each clinical entity was individually studied for specific features. Results: The mean age of presentation of rheumatic disorders was 33 years with the maximum number of patients (n=61) belonged to the age group of 20-40 years. Females outnumbered males (ratio of 1:2.225). Disorders like lupus and scleroderma were the most common rheumatic entity in this series. Besides these, vasculitis, Behcet’s disease, rheumatic arthritis, psoriatic arthritis and others also have significant cutaneous manifestations. Conclusions: Some rheumatic disease have significant cutaneous manifestations, understanding of which is essential for their proper management.
{"title":"Pattern of dermatological manifestations among patients of rheumatic disorders at a tertiary care centre from Kashmir valley in North India","authors":"F. Sameem, Samia Aleem, Sumaiya Majeed, Aaqib Aslam, Seerat Fatima, S. Manzoor","doi":"10.18203/issn.2455-4529.intjresdermatol20231162","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231162","url":null,"abstract":"Background: Various rheumatic disorders have cutaneous manifestations which sometimes precede systemic symptoms. These manifestations, therefore can act as diagnostic and prognostic markers of the rheumatic disorders. Understanding them may lead to early diagnosis, prompt treatment, and hence lower morbidity and mortality of the affected persons. The aims and objectives were to study the pattern of dermatological manifestations among patients of rheumatic disorders at a tertiary care centre from Kashmir valley in North India.\u0000Methods: Prospective observational study carried out in the department of Dermatology at SKIMS medical college in Kashmir valley in north India over a span of 12 months from July 2021 to June 2022. A sample size of 100 native Kashmiri patients of rheumatic disorders presenting to OPD with dermatological manifestations were included in the study. A detailed dermatological examination and history was taken. The various demographic data sought included age, gender, occupation, residence and clinical diagnosis. Each clinical entity was individually studied for specific features.\u0000Results: The mean age of presentation of rheumatic disorders was 33 years with the maximum number of patients (n=61) belonged to the age group of 20-40 years. Females outnumbered males (ratio of 1:2.225). Disorders like lupus and scleroderma were the most common rheumatic entity in this series. Besides these, vasculitis, Behcet’s disease, rheumatic arthritis, psoriatic arthritis and others also have significant cutaneous manifestations.\u0000Conclusions: Some rheumatic disease have significant cutaneous manifestations, understanding of which is essential for their proper management.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"291 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91510705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.18203/issn.2455-4529.intjresdermatol20231166
M. S, Monisha Narasingan
Exercise has become an integral part of life in this modern era due to sedentary lifestyle. Although, urticaria patients are being evaluated for all the common triggering factors like food, environmental allergens and infections, an entity called exercise induced urticaria often get missed. Exertional and asymptomatic rhabdomyolysis must be kept in mind during evaluation. A 27 year male patient was diagnosed with severe exercise induced urticaria with muscle injury. Patient developed urticaria within 30 minutes of strenuous exercise. Clinical history was insignificant for any allergen exposure except for clear history of urticaria once weekly after strenuous exercise. Patient also reported need for oral analgesics on the day of strenuous exercise indicating muscle injury. Asymptomatic phase correlated with abstinence of exercise. His lesions gradually got relieved with anti-histamines. Routine blood investigations were normal except elevation of aspartate aminotransferase (AST-354U/L), Lactate dehydrogenase (LDH-619U/L) and normal alanine aminotransferase (ALT-51U/L), altered AST/ALT ratio more than 6. Creatinine kinase (CK) can increase ten folds in healthy individuals following strenuous exercise. Hence, CK was not done for this patient. Aminotransferases may remain elevated even after normalisation of CK up to 2-3 weeks. LDH was done as an additional investigation. Simple routine investigation for altered AST and confirmation with LDH or CK for its source from muscle injury can be done. Severe exercise induced urticaria with muscle injury can be managed with moderation of exercise intensity along with short course of antihistamines owing to the benefit of exercise. This patient was followed up for 2 years and there was no episode of urticaria after stepping down the exercise intensity. Detailed history of exercise duration and intensity is required along with basic investigations for evaluating exercise induced urticaria. A sub-entity called severe exercise induced urticaria with muscle injury must be kept in mind due to the risk of asymptomatic or exertional rhabdomyolysis.
{"title":"Exercise-induced urticaria with muscle injury: a case report","authors":"M. S, Monisha Narasingan","doi":"10.18203/issn.2455-4529.intjresdermatol20231166","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231166","url":null,"abstract":"Exercise has become an integral part of life in this modern era due to sedentary lifestyle. Although, urticaria patients are being evaluated for all the common triggering factors like food, environmental allergens and infections, an entity called exercise induced urticaria often get missed. Exertional and asymptomatic rhabdomyolysis must be kept in mind during evaluation. A 27 year male patient was diagnosed with severe exercise induced urticaria with muscle injury. Patient developed urticaria within 30 minutes of strenuous exercise. Clinical history was insignificant for any allergen exposure except for clear history of urticaria once weekly after strenuous exercise. Patient also reported need for oral analgesics on the day of strenuous exercise indicating muscle injury. Asymptomatic phase correlated with abstinence of exercise. His lesions gradually got relieved with anti-histamines. Routine blood investigations were normal except elevation of aspartate aminotransferase (AST-354U/L), Lactate dehydrogenase (LDH-619U/L) and normal alanine aminotransferase (ALT-51U/L), altered AST/ALT ratio more than 6. Creatinine kinase (CK) can increase ten folds in healthy individuals following strenuous exercise. Hence, CK was not done for this patient. Aminotransferases may remain elevated even after normalisation of CK up to 2-3 weeks. LDH was done as an additional investigation. Simple routine investigation for altered AST and confirmation with LDH or CK for its source from muscle injury can be done. Severe exercise induced urticaria with muscle injury can be managed with moderation of exercise intensity along with short course of antihistamines owing to the benefit of exercise. This patient was followed up for 2 years and there was no episode of urticaria after stepping down the exercise intensity. Detailed history of exercise duration and intensity is required along with basic investigations for evaluating exercise induced urticaria. A sub-entity called severe exercise induced urticaria with muscle injury must be kept in mind due to the risk of asymptomatic or exertional rhabdomyolysis.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72827254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.18203/issn.2455-4529.intjresdermatol20231171
Ait Khabba Chaimae, Mehsas Zoubida, Asermouh Marwa, Meziane Meriem, Ismaili Nadia, B. Laila, Senouci Karima
Vesiculo-bullous lesions as well as the late onset are extremely rare features of Darier disease (DD) making positive diagnosis more difficult. Its association with polycythemia vera prompts to look for signs suggestive of malignant hematological transformation. We report a case of a 62-year-old patient, followed in internal medicine since the age of 58 for polycythemia vera. She presented for pruriginous vesiculo-bullous dermatosis evolving for 4 years. On clinical examination, papulo-vesicular plaques were found involving all the folds: inguinal, axillary, inter-gluteal, neck and body with palmo-plantar blisters and pustules. Examination of the toe nails showed alternating red and white longitudinal bands. Abdominal examination showed moderate splenomegaly. Skin biopsy revealed focal acantholysis with supra-basal clefts, dyskeratosis with the presence of round bodies and grains compatible with Darier's disease. A paraneoplastic assessment was made including a thoraco-abdomino-pelvic CT scan, a breast ultrasound and mammography with cervico-vaginal smear, a CT scan of the cavum and a pancreatic MRI, which did not show any progressive malignant process. The patient was put on oral retinoids at a rate of 0.5 mg/kg per day and topical calcipotriol associated with bloodletting to reduce the hematocrit level. The evolution was marked by clinical improvement. The patient was followed in the hematology department and showed no acute leukemia or myelofibrosis or other neoplasms after a 2-year follow-up. We report a case of late DD in a woman followed for polycythemia vera, characterized by a rare vesiculo-bullous presentation and whose causal link remains to be determined.
{"title":"Vesiculo-bullous Darier disease late onset in association with polycythemia vera","authors":"Ait Khabba Chaimae, Mehsas Zoubida, Asermouh Marwa, Meziane Meriem, Ismaili Nadia, B. Laila, Senouci Karima","doi":"10.18203/issn.2455-4529.intjresdermatol20231171","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231171","url":null,"abstract":"Vesiculo-bullous lesions as well as the late onset are extremely rare features of Darier disease (DD) making positive diagnosis more difficult. Its association with polycythemia vera prompts to look for signs suggestive of malignant hematological transformation. We report a case of a 62-year-old patient, followed in internal medicine since the age of 58 for polycythemia vera. She presented for pruriginous vesiculo-bullous dermatosis evolving for 4 years. On clinical examination, papulo-vesicular plaques were found involving all the folds: inguinal, axillary, inter-gluteal, neck and body with palmo-plantar blisters and pustules. Examination of the toe nails showed alternating red and white longitudinal bands. Abdominal examination showed moderate splenomegaly. Skin biopsy revealed focal acantholysis with supra-basal clefts, dyskeratosis with the presence of round bodies and grains compatible with Darier's disease. A paraneoplastic assessment was made including a thoraco-abdomino-pelvic CT scan, a breast ultrasound and mammography with cervico-vaginal smear, a CT scan of the cavum and a pancreatic MRI, which did not show any progressive malignant process. The patient was put on oral retinoids at a rate of 0.5 mg/kg per day and topical calcipotriol associated with bloodletting to reduce the hematocrit level. The evolution was marked by clinical improvement. The patient was followed in the hematology department and showed no acute leukemia or myelofibrosis or other neoplasms after a 2-year follow-up. We report a case of late DD in a woman followed for polycythemia vera, characterized by a rare vesiculo-bullous presentation and whose causal link remains to be determined.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86069126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.18203/issn.2455-4529.intjresdermatol20231167
Sektaoui Soukaina, Mehsas Zoubida, B. Laila, Senouci Karima
Crohn's disease (CD) is an inflammatory bowel disease (IBD) that can present with cutaneous lesions, including metastatic lesions. Vulvar CD is a rare manifestation of the disease, with only a few reported cases in the literature. Here we present the case of a 45-year-old woman with metastatic vulvar CD who presented with a one-year history of painful genital swelling. Diagnosis was confirmed through histopathology of the genital lesion. Diagnosis of vulvar CD can be challenging, as the clinical presentation is highly variable. Clinicians should consider the possibility of vulvar CD in patients presenting with aphthous ulcerations, vulvar edema, lymphedema, or lymphangiectasia. Medical treatment options for vulvar CD include corticosteroids, azathioprine, systemic sulfasalazine, cyclosporine, ciprofloxacin, and long-term metronidazole, while surgical interventions include partial or total vulvectomy, laser vaporization, or excision of the lesion. Diagnosis of CD is important, and various diagnostic tools should be used to search for digestive CD. The evolution of vulvar CD can be unpredictable, and surgical intervention may be required when medical treatment fails.
{"title":"A case of clitoral Crohn's disease","authors":"Sektaoui Soukaina, Mehsas Zoubida, B. Laila, Senouci Karima","doi":"10.18203/issn.2455-4529.intjresdermatol20231167","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231167","url":null,"abstract":"Crohn's disease (CD) is an inflammatory bowel disease (IBD) that can present with cutaneous lesions, including metastatic lesions. Vulvar CD is a rare manifestation of the disease, with only a few reported cases in the literature. Here we present the case of a 45-year-old woman with metastatic vulvar CD who presented with a one-year history of painful genital swelling. Diagnosis was confirmed through histopathology of the genital lesion. Diagnosis of vulvar CD can be challenging, as the clinical presentation is highly variable. Clinicians should consider the possibility of vulvar CD in patients presenting with aphthous ulcerations, vulvar edema, lymphedema, or lymphangiectasia. Medical treatment options for vulvar CD include corticosteroids, azathioprine, systemic sulfasalazine, cyclosporine, ciprofloxacin, and long-term metronidazole, while surgical interventions include partial or total vulvectomy, laser vaporization, or excision of the lesion. Diagnosis of CD is important, and various diagnostic tools should be used to search for digestive CD. The evolution of vulvar CD can be unpredictable, and surgical intervention may be required when medical treatment fails.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73316669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.18203/issn.2455-4529.intjresdermatol20231170
Ruchi M. Bhandare
Erythema elevatum diutinum (EED) is a rare chronic dermatosis which mostly affects adult individuals. The classical skin lesions are asymptomatic, plum colored, erythematous nodules and plaques of variable sizes distributed symmetrically over extensor aspect of extremities. We reported a case of EED in a 50-year-old female presenting with lesions involving palms owing to its rare presentation.
{"title":"Erythema elevatum diutinum: a rare case of atypical presentation involving palms","authors":"Ruchi M. Bhandare","doi":"10.18203/issn.2455-4529.intjresdermatol20231170","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231170","url":null,"abstract":"Erythema elevatum diutinum (EED) is a rare chronic dermatosis which mostly affects adult individuals. The classical skin lesions are asymptomatic, plum colored, erythematous nodules and plaques of variable sizes distributed symmetrically over extensor aspect of extremities. We reported a case of EED in a 50-year-old female presenting with lesions involving palms owing to its rare presentation.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74318228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-04DOI: 10.18203/issn.2455-4529.intjresdermatol20231013
Andrea Sierra Franco, María Jimena Talamante Madrid, Reneta Montserrat Espejo Nuño, Daniela Alejandra Davila Baeza, Martha Yanelly Espinoza Hernández, Edit Cano Muñoz
Leishmaniasis is a chronic, vector-borne parasitic disease caused by a flagellated protozoan of the genus Leishmania, which has more than 20 species. Usually, it is a disease that affects the tropical and subtropical populations of the world. The disease is transmitted through the bite of female mosquitoes of the genus Lutzomyiaen and Phlebotomusen. The clinical presentation and its manifestations are variable, they are affected by the species and immunological state of the host. Generally, three main types are distinguished: the most frequent presentation and with the best prognosis is cutaneous leishmaniasis (CL), the second is known as mucocutaneous leishmaniasis (MCL), and the third presentation is visceral leishmaniasis, which puts endanger the life of the person presenting it. Leishmaniasis is related to various risk factors, including: poverty, malnutrition, migration, and inadequate housing conditions; in addition, people who work in rural areas, such as farmers, farmers, or the military in endemic areas, are at greater risk of suffering a bite by a transmitting mosquito. Due to its variable manifestations and greater affectation in poor areas, it is a pathology that is normally overlooked. The objective of this review is to define and differentiate the most frequent types of presentation as well as their cutaneous manifestations, and to provide extensive information on diagnostic methods. Briefly, general information on the pathology and treatment of these lesions will be provided.
{"title":"Cutaneous leishmaniasis: an underdiagnosed entity in the first contact","authors":"Andrea Sierra Franco, María Jimena Talamante Madrid, Reneta Montserrat Espejo Nuño, Daniela Alejandra Davila Baeza, Martha Yanelly Espinoza Hernández, Edit Cano Muñoz","doi":"10.18203/issn.2455-4529.intjresdermatol20231013","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231013","url":null,"abstract":"Leishmaniasis is a chronic, vector-borne parasitic disease caused by a flagellated protozoan of the genus Leishmania, which has more than 20 species. Usually, it is a disease that affects the tropical and subtropical populations of the world. The disease is transmitted through the bite of female mosquitoes of the genus Lutzomyiaen and Phlebotomusen. The clinical presentation and its manifestations are variable, they are affected by the species and immunological state of the host. Generally, three main types are distinguished: the most frequent presentation and with the best prognosis is cutaneous leishmaniasis (CL), the second is known as mucocutaneous leishmaniasis (MCL), and the third presentation is visceral leishmaniasis, which puts endanger the life of the person presenting it. Leishmaniasis is related to various risk factors, including: poverty, malnutrition, migration, and inadequate housing conditions; in addition, people who work in rural areas, such as farmers, farmers, or the military in endemic areas, are at greater risk of suffering a bite by a transmitting mosquito. Due to its variable manifestations and greater affectation in poor areas, it is a pathology that is normally overlooked. The objective of this review is to define and differentiate the most frequent types of presentation as well as their cutaneous manifestations, and to provide extensive information on diagnostic methods. Briefly, general information on the pathology and treatment of these lesions will be provided.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"15 12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86983827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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