Pub Date : 2023-12-22DOI: 10.18203/issn.2455-4529.intjresdermatol20233878
Sanjana Saikumar, T. P. Thankappan, P. K. Balachandran, Asha Thankappan, Shabna Shihabudeen, Antony P. Kanichai
Collagenoma, also known as collagen naevus, is a connective tissue hamartoma which manifests as a single or localized group of fibrous dermal papules and plaques on the skin, and is characterized by increase in dermal collagen with normal or reduced elastin on histopathology. Cases have been reported in Down syndrome, as isolated or localized lesions, and were presumed to be due to altered free radical metabolism by the enzyme superoxide dismutase, its gene being located on chromosome 21. However, eruptive collagenoma in Down syndrome patients are rarely reported. We present a 22-year-old male Down syndrome patient with asymptomatic eruption of skin lesions on trunk and upper extremities since the past 18 months. He was offered surgical and laser therapy, but at his request, we kept him on regular follow-up.
{"title":"Unraveling a mysterious skin eruption in a case of Down syndrome","authors":"Sanjana Saikumar, T. P. Thankappan, P. K. Balachandran, Asha Thankappan, Shabna Shihabudeen, Antony P. Kanichai","doi":"10.18203/issn.2455-4529.intjresdermatol20233878","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20233878","url":null,"abstract":"Collagenoma, also known as collagen naevus, is a connective tissue hamartoma which manifests as a single or localized group of fibrous dermal papules and plaques on the skin, and is characterized by increase in dermal collagen with normal or reduced elastin on histopathology. Cases have been reported in Down syndrome, as isolated or localized lesions, and were presumed to be due to altered free radical metabolism by the enzyme superoxide dismutase, its gene being located on chromosome 21. However, eruptive collagenoma in Down syndrome patients are rarely reported. We present a 22-year-old male Down syndrome patient with asymptomatic eruption of skin lesions on trunk and upper extremities since the past 18 months. He was offered surgical and laser therapy, but at his request, we kept him on regular follow-up.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"43 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139164725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-22DOI: 10.18203/issn.2455-4529.intjresdermatol20233873
Prateek Pathak, Mohammad Adil, Fariz Sarshar, Jyoti Singh
Background: Androgenetic Alopecia is a hereditary androgen-dependent disorder characterized by a gradual conversion of terminal hair into miniaturized hair with typical bitemporal recession and balding vertex and is considered the most common type of baldness characterized by progressive hair loss. This study evaluated the hormonal profile in males with androgenetic alopecia. This study evaluated the hormonal profile of early androgenetic alopecia in males. Methods: This prospective study included 84 patients attending the outpatient Department of Dermatology. Forty-four cases and 40 controls were included in the study. The study had 44 male patients presenting with complaints of grade ≥ 3 androgenetic alopecia in the age group 19-35 years, whereas 40 age and sex-matched patients attending Dermatology OPD for unrelated complaints with no history of hair loss or clinical examination suggestive of androgenetic alopecia were included in the control group. After a detailed history, and examination, testosterone, LH, FSH, Prolactin, and SHBG were estimated. Results: The mean age of onset was found to be 24.29±3.28 years. Positive family history was seen in 65.90% of patients. The mean testosterone, LH, FSH, prolactin, SHBG and free androgen index in cases versus controls was 6.44±2.58 versus 3.32±1.53 ng/ml, 8.01±2.64 IU/l versus 3.01±1.16 IU/l, 3.82±1.33 IU/l versus 5.07±1.27 IU/l, 15.50±5.11 ng/ml versus 9.84±3.91 ng/ml, 12.72±2.63 nmol/l versus 29.18±4.90 nmol/l and 51.03±21.78 versus 11.40±4.66 respectively. LH/FSH ratio was 2.17±0.54 versus 0.63±0.27. These parameters had p values <0.05 and were statistically significant. Conclusions: Our study concluded that serum testosterone, prolactin, LH, LH/FSH, and FAI are increased whereas serum FSH and SHBG are decreased in cases of androgenetic alopecia compared to controls.
{"title":"Androgenetic alopecia: evaluation of hormonal profile and its systemic implications","authors":"Prateek Pathak, Mohammad Adil, Fariz Sarshar, Jyoti Singh","doi":"10.18203/issn.2455-4529.intjresdermatol20233873","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20233873","url":null,"abstract":"Background: Androgenetic Alopecia is a hereditary androgen-dependent disorder characterized by a gradual conversion of terminal hair into miniaturized hair with typical bitemporal recession and balding vertex and is considered the most common type of baldness characterized by progressive hair loss. This study evaluated the hormonal profile in males with androgenetic alopecia. This study evaluated the hormonal profile of early androgenetic alopecia in males. Methods: This prospective study included 84 patients attending the outpatient Department of Dermatology. Forty-four cases and 40 controls were included in the study. The study had 44 male patients presenting with complaints of grade ≥ 3 androgenetic alopecia in the age group 19-35 years, whereas 40 age and sex-matched patients attending Dermatology OPD for unrelated complaints with no history of hair loss or clinical examination suggestive of androgenetic alopecia were included in the control group. After a detailed history, and examination, testosterone, LH, FSH, Prolactin, and SHBG were estimated. Results: The mean age of onset was found to be 24.29±3.28 years. Positive family history was seen in 65.90% of patients. The mean testosterone, LH, FSH, prolactin, SHBG and free androgen index in cases versus controls was 6.44±2.58 versus 3.32±1.53 ng/ml, 8.01±2.64 IU/l versus 3.01±1.16 IU/l, 3.82±1.33 IU/l versus 5.07±1.27 IU/l, 15.50±5.11 ng/ml versus 9.84±3.91 ng/ml, 12.72±2.63 nmol/l versus 29.18±4.90 nmol/l and 51.03±21.78 versus 11.40±4.66 respectively. LH/FSH ratio was 2.17±0.54 versus 0.63±0.27. These parameters had p values <0.05 and were statistically significant. Conclusions: Our study concluded that serum testosterone, prolactin, LH, LH/FSH, and FAI are increased whereas serum FSH and SHBG are decreased in cases of androgenetic alopecia compared to controls.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"28 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139165363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-22DOI: 10.18203/issn.2455-4529.intjresdermatol20233880
Monika Kulhari, Prateek Pathak, P. K. Singh
Halo scalp ring is a rare less frequently diagnosed non scarring alopecia seen in neonatal period. Although a few cases can land up in scarring alopecia if necrosis and deep inflammation due to Caput Succedeneum supervenes. It is imperative to diagnose the condition as various forms of alopecias in infants can lead to psychological disturbance among parents. Herein we report a case of Halo Scalp Ring alopecia so as to keep in mind this condition so that unnecessary investigations of the child can be avoided and in case scarring occurs the child can be referred on time to a plastic surgeon for hair restoration surgeries.
{"title":"Halo scalp ring: an undiagnosed neonatal scalp alopecia","authors":"Monika Kulhari, Prateek Pathak, P. K. Singh","doi":"10.18203/issn.2455-4529.intjresdermatol20233880","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20233880","url":null,"abstract":"Halo scalp ring is a rare less frequently diagnosed non scarring alopecia seen in neonatal period. Although a few cases can land up in scarring alopecia if necrosis and deep inflammation due to Caput Succedeneum supervenes. It is imperative to diagnose the condition as various forms of alopecias in infants can lead to psychological disturbance among parents. Herein we report a case of Halo Scalp Ring alopecia so as to keep in mind this condition so that unnecessary investigations of the child can be avoided and in case scarring occurs the child can be referred on time to a plastic surgeon for hair restoration surgeries.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139165257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-22DOI: 10.18203/issn.2455-4529.intjresdermatol20233874
Priyanka Thakur, K. Mehta, P. Chauhan, Ravinder Singh, A. Sharma, Anuj Sharma, Reena Sharma, Prabal Kumar, Sanket Vashist, Sujaya Manvi, Amisha Kukreja, Rohit Negi
Background: Vitiligo is an acquired disorder of depigmentation which involves skin and mucous membranes characterized by development of well-defined white macules on skin, mucosa and overlying hair of the skin can be involved. Systemic nature of the vitiligo might lead to insulin resistance metabolic profile abnormalities. Objective was to study the association between vitiligo and metabolic syndrome. Methods: The study was done in department of dermatology, venereology and leprosy of Dr. R. P. Government Medical College Kangra (Tanda), Himachal Pradesh. The study included 150 cases and 150 controls. Cases: age above 18 years with a diagnosis of vitiligo were included in the study. Pregnant and lactating women were excluded. Patients who had used medications that could affect the metabolic status (like systemic steroid therapy or cyclosporine or on hormonal replacement therapy). Patients already on lipid lowering agents and antidiabetic drugs. The case group was further subdivided into three subgroups according to VIDA score (group A: 1-0, group B: 1-2 and group C: 3-4). Controls: those visiting outdoor patient department and admitted for minor day care procedures Clinical details of patients were recorded regarding age, sex, smoking/alcohol consumption. General physical examination includes height, weight, body mass index, waist circumference, blood pressure. All the patients and controls were subjected to following tests: fasting blood sugar (FBS), cholesterol (CHOL), triglyceride (TAG), low density lipoprotein (LDL), high density lipoprotein (HDL), very low-density lipoprotein (VLDL), fasting serum insulin level (FSIL). Venous samples were taken after 12 hours of fasting. The participants were screened for metabolic syndrome as per national cholesterol education program adult treatment panel III (NCEP ATP III). Metabolic syndrome rates were compared between case and control groups. Results: The mean age was 35.82±12.9 years among cases and 36.97±11.76 years among controls. The M/F ratio of cases being (1:1.6) and controls (1:1). The mean duration of vitiligo was 117.8±105.5 months. Metabolic syndrome was significantly prevalent amid vitiligo cases 74 (49.3%) as compared to controls 23 (15.3%) with OR (95% CI) =5.37 (3.1-9.3). Metabolic syndrome was more frequent in VIDA subgroup 3{71 (47.3%)} and was statistically significant (p≤0.001). Conclusions: The study found association of metabolic syndrome among vitiligo patients. In addition, the study also found that in non-segmental vitiligo, frequency of metabolic syndrome was higher as compared to another pattern. Furthermore, frequency of metabolic syndrome increased as activity of vitiligo increased in the study.
背景：白癜风是一种获得性色素脱失症，涉及皮肤和粘膜，其特征是在皮肤、粘膜和皮肤覆盖的毛发上出现界限清晰的白色斑块。白癜风的全身性可能会导致胰岛素抵抗代谢异常。目的：研究白癜风与代谢综合征之间的关系。研究方法研究在喜马偕尔邦康拉（坦达）R. P. 博士政府医学院皮肤病学、性病学和麻风病系进行。研究包括 150 例病例和 150 例对照。病例：年龄在 18 岁以上、确诊为白癜风的患者均被纳入研究范围。孕妇和哺乳期妇女除外。使用过可能影响代谢状态的药物（如全身性类固醇治疗或环孢素或激素替代疗法）的患者。已服用降脂药和抗糖尿病药物的患者。根据 VIDA 评分，病例组又细分为三个亚组（A 组：1-0；B 组：1-2；C 组：3-4）。对照组：到室外患者科室就诊和接受日间护理小手术的患者 记录了患者的年龄、性别、吸烟/饮酒情况等详细资料。一般体格检查包括身高、体重、体重指数、腰围和血压。所有患者和对照组均接受了以下检测：空腹血糖（FBS）、胆固醇（CHOL）、甘油三酯（TAG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、极低密度脂蛋白（VLDL）、空腹血清胰岛素水平（FSIL）。空腹 12 小时后采集静脉样本。根据美国国家胆固醇教育计划成人治疗小组 III（NCEP ATP III）对参与者进行了代谢综合征筛查。比较病例组和对照组的代谢综合征发生率。结果病例组平均年龄（35.82±12.9）岁，对照组平均年龄（36.97±11.76）岁。病例的男女比例为（1:1.6），对照组为（1:1）。白癜风的平均病程为（117.8±105.5）个月。与对照组的 23 例（15.3%）（OR (95% CI) =5.37 (3.1-9.3)）相比，代谢综合征在 74 例（49.3%）白癜风患者中明显多见。代谢综合征在 VIDA 亚组 3{71 (47.3%)} 中更为常见，且具有统计学意义（P≤0.001）。结论研究发现，白癜风患者中存在代谢综合征。此外，研究还发现，在非节段型白癜风患者中，代谢综合征的发病率高于其他类型。此外，代谢综合征的发生率随着白癜风活动度的增加而增加。
{"title":"Association of vitiligo and metabolic syndrome: a case control study","authors":"Priyanka Thakur, K. Mehta, P. Chauhan, Ravinder Singh, A. Sharma, Anuj Sharma, Reena Sharma, Prabal Kumar, Sanket Vashist, Sujaya Manvi, Amisha Kukreja, Rohit Negi","doi":"10.18203/issn.2455-4529.intjresdermatol20233874","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20233874","url":null,"abstract":"Background: Vitiligo is an acquired disorder of depigmentation which involves skin and mucous membranes characterized by development of well-defined white macules on skin, mucosa and overlying hair of the skin can be involved. Systemic nature of the vitiligo might lead to insulin resistance metabolic profile abnormalities. Objective was to study the association between vitiligo and metabolic syndrome. Methods: The study was done in department of dermatology, venereology and leprosy of Dr. R. P. Government Medical College Kangra (Tanda), Himachal Pradesh. The study included 150 cases and 150 controls. Cases: age above 18 years with a diagnosis of vitiligo were included in the study. Pregnant and lactating women were excluded. Patients who had used medications that could affect the metabolic status (like systemic steroid therapy or cyclosporine or on hormonal replacement therapy). Patients already on lipid lowering agents and antidiabetic drugs. The case group was further subdivided into three subgroups according to VIDA score (group A: 1-0, group B: 1-2 and group C: 3-4). Controls: those visiting outdoor patient department and admitted for minor day care procedures Clinical details of patients were recorded regarding age, sex, smoking/alcohol consumption. General physical examination includes height, weight, body mass index, waist circumference, blood pressure. All the patients and controls were subjected to following tests: fasting blood sugar (FBS), cholesterol (CHOL), triglyceride (TAG), low density lipoprotein (LDL), high density lipoprotein (HDL), very low-density lipoprotein (VLDL), fasting serum insulin level (FSIL). Venous samples were taken after 12 hours of fasting. The participants were screened for metabolic syndrome as per national cholesterol education program adult treatment panel III (NCEP ATP III). Metabolic syndrome rates were compared between case and control groups. Results: The mean age was 35.82±12.9 years among cases and 36.97±11.76 years among controls. The M/F ratio of cases being (1:1.6) and controls (1:1). The mean duration of vitiligo was 117.8±105.5 months. Metabolic syndrome was significantly prevalent amid vitiligo cases 74 (49.3%) as compared to controls 23 (15.3%) with OR (95% CI) =5.37 (3.1-9.3). Metabolic syndrome was more frequent in VIDA subgroup 3{71 (47.3%)} and was statistically significant (p≤0.001). Conclusions: The study found association of metabolic syndrome among vitiligo patients. In addition, the study also found that in non-segmental vitiligo, frequency of metabolic syndrome was higher as compared to another pattern. Furthermore, frequency of metabolic syndrome increased as activity of vitiligo increased in the study.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"172 S384","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139165646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-22DOI: 10.18203/issn.2455-4529.intjresdermatol20233881
Dipesh M. Waghmare, I. Purkait, Anil Pareek
The aim of the present article is to analyze the role of emollients in the topical management of atopic dermatitis and psoriasis and also to review the clinical studies available on the beneficial effect of co-therapy of emollients and topical corticosteroids. Understanding the stratum corneum's key involvement in the pathophysiology of atopic dermatitis and psoriasis has led to the development of new therapeutic approaches for treating not just inflammation but also restoring a healthy skin barrier. While topical corticosteroids are the cornerstones of treatment for atopic dermatitis and psoriasis, the potential risks of overuse (including atrophy, striae, dyspigmentation, and loss in epidermal barrier homeostasis) must be weighed against the benefits. These risks futher increase the necessity of finding non-steroidal treatments. Emollients aid the epidermal barrier function as they improve the oil and lipid levels and restore its protective function. Used regularly, emollients may reduce flare-ups and may also have a direct anti-inflammatory effect and may reduce the need to use topical corticosteroids, i.e. they have a ‘steroid sparing effect’.
{"title":"Steroid-sparing effect of emollients in atopic dermatitis and psoriasis","authors":"Dipesh M. Waghmare, I. Purkait, Anil Pareek","doi":"10.18203/issn.2455-4529.intjresdermatol20233881","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20233881","url":null,"abstract":"The aim of the present article is to analyze the role of emollients in the topical management of atopic dermatitis and psoriasis and also to review the clinical studies available on the beneficial effect of co-therapy of emollients and topical corticosteroids. Understanding the stratum corneum's key involvement in the pathophysiology of atopic dermatitis and psoriasis has led to the development of new therapeutic approaches for treating not just inflammation but also restoring a healthy skin barrier. While topical corticosteroids are the cornerstones of treatment for atopic dermatitis and psoriasis, the potential risks of overuse (including atrophy, striae, dyspigmentation, and loss in epidermal barrier homeostasis) must be weighed against the benefits. These risks futher increase the necessity of finding non-steroidal treatments. Emollients aid the epidermal barrier function as they improve the oil and lipid levels and restore its protective function. Used regularly, emollients may reduce flare-ups and may also have a direct anti-inflammatory effect and may reduce the need to use topical corticosteroids, i.e. they have a ‘steroid sparing effect’.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"30 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139166095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-22DOI: 10.18203/issn.2455-4529.intjresdermatol20233877
Shafaq Khan, Prateek Pathak, Monika Kulhari, P. K. Singh
With the advent of isotretinoin in the last 2 decades, dermatotheraputics has reached a major milestone especially in treating moderate to severe acne. Oral isotretinoin is an isomer of all-trans retinoic acid and a metabolite of retinol (vitamin A). In addition to its excellent response in moderate to severe acne, there are a number of well-documented side effects related to the use of isotretinoin. Lobular capillary haemangioma is a very rare side effect. It is sometimes known as granuloma pyogenicum and it is an acquired, benign vascular tumor that arises in tissues such as the skin and mucous membranes. Herein, we report a case of isotretinoin-induced lobular capillary hemangioma over the scalp (an atypical site).
{"title":"Oral isotretinoin induced giant lobular capillary haemangioma over scalp: a rare case report","authors":"Shafaq Khan, Prateek Pathak, Monika Kulhari, P. K. Singh","doi":"10.18203/issn.2455-4529.intjresdermatol20233877","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20233877","url":null,"abstract":"With the advent of isotretinoin in the last 2 decades, dermatotheraputics has reached a major milestone especially in treating moderate to severe acne. Oral isotretinoin is an isomer of all-trans retinoic acid and a metabolite of retinol (vitamin A). In addition to its excellent response in moderate to severe acne, there are a number of well-documented side effects related to the use of isotretinoin. Lobular capillary haemangioma is a very rare side effect. It is sometimes known as granuloma pyogenicum and it is an acquired, benign vascular tumor that arises in tissues such as the skin and mucous membranes. Herein, we report a case of isotretinoin-induced lobular capillary hemangioma over the scalp (an atypical site).","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"36 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139164782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-22DOI: 10.18203/issn.2455-4529.intjresdermatol20233876
Janani Ramamurthy, Brinda G. David
Background: Pregnancy causes various physiological and pathological changes of skin, due to profound immunological, endocrine and vascular changes. This study focus on these changes and hence earlier identification of pathological skin changes helps to improve both the maternal and fetal outcomes. Aims and objectives were to find the prevalence and patterns of these changes in pregnancy and also to find the association of pathological changes with gravida and gestational age. Methods: A cross sectional study was performed among 250 pregnant women with skin changes, attending dermatology outpatient department (OPD) at tertiary care centre in Puducherry and the findings were documented and the data was analyzed for statistical significance. Results: In this study, Physiological changes were most common of which linea nigra was commonly seen in (84.4%) cases (n=233) followed by striae distensae seen in (78.4%) cases (n=197). Similarly, in pathological specific dermatoses, polymorphic eruption of pregnancy was seen in (1.2%) cases (n=3), followed by atopic eruption of pregnancy was seen in (0.4%) cases (n=1). Among the pathological non-specific dermatoses, Acne vulgaris in the inflammatory diseases was seen commonly in (7.6%) cases (n=19), followed by cutaneous infections like Tinea corporis was seen in (8.4%) cases (n=21) and least common was alopecia areata seen in (0.4%) of cases among the autoimmune disorders. Conclusions: In this study physiological changes were more common in pregnant women followed by pathological non-specific and specific dermatoses. Also, there was a significant association of pathological changes with gravida and gestational age by Chi-square test with the p value <0.05.
{"title":"Clinico-epidemiological study of cutaneous changes in pregnancy at a tertiary care centre in Puducherry","authors":"Janani Ramamurthy, Brinda G. David","doi":"10.18203/issn.2455-4529.intjresdermatol20233876","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20233876","url":null,"abstract":"Background: Pregnancy causes various physiological and pathological changes of skin, due to profound immunological, endocrine and vascular changes. This study focus on these changes and hence earlier identification of pathological skin changes helps to improve both the maternal and fetal outcomes. Aims and objectives were to find the prevalence and patterns of these changes in pregnancy and also to find the association of pathological changes with gravida and gestational age. Methods: A cross sectional study was performed among 250 pregnant women with skin changes, attending dermatology outpatient department (OPD) at tertiary care centre in Puducherry and the findings were documented and the data was analyzed for statistical significance. Results: In this study, Physiological changes were most common of which linea nigra was commonly seen in (84.4%) cases (n=233) followed by striae distensae seen in (78.4%) cases (n=197). Similarly, in pathological specific dermatoses, polymorphic eruption of pregnancy was seen in (1.2%) cases (n=3), followed by atopic eruption of pregnancy was seen in (0.4%) cases (n=1). Among the pathological non-specific dermatoses, Acne vulgaris in the inflammatory diseases was seen commonly in (7.6%) cases (n=19), followed by cutaneous infections like Tinea corporis was seen in (8.4%) cases (n=21) and least common was alopecia areata seen in (0.4%) of cases among the autoimmune disorders. Conclusions: In this study physiological changes were more common in pregnant women followed by pathological non-specific and specific dermatoses. Also, there was a significant association of pathological changes with gravida and gestational age by Chi-square test with the p value <0.05.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"190 S523","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139165729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-22DOI: 10.18203/issn.2455-4529.intjresdermatol20233875
Monika Kulhari, Mohammad Adil, Iti Varshney, S. Amin
Background: Alopecia areata (AA) is an autoimmune disorder and exhibits non scarring alopecia. Currently, there is no definitive cure, platelet rich plasma (PRP) has emerged as a newer modality for non-cicatricial alopecias such as AA. This study was conducted to compare the efficacy and adverse effects of topical mometasone with PRP versus topical mometasone alone in the treatment of patients of AA. Methods: This study was conducted on a total of 100 clinically diagnosed cases of AA. Patients in group A were subjected to intradermal injection of autologous PRP every 3 weeks along with topical mometasone cream 0.1% daily for 12 weeks. Group B was treated with topical mometasone cream 0.1% once a day locally over affected site for 12 weeks. Results: Baseline SALT score of group A was 6.05±5.36 while that of group B was 6.62±4.39. The mean SALT score of group A declined to 0.94±1.69 and that of group B 2.19±1.76 over a period of 20 weeks. Excellent response was observed by 12 and 5 patients of group A and group B respectively. Minor side effects like pain was seen in 10 patients (20%) in group A, while atrophy was seen in 2 patients of group B. Conclusions: This is the first ever study evaluating the additional benefit of intralesional PRP. In this study, it was found that adding intralesional PRP with topical mometasone 0.1% cream has higher efficacy and early improvement than topical mometasone alone, in the treatment of AA.
背景介绍斑秃（AA）是一种自身免疫性疾病，表现为非瘢痕性脱发。目前尚无根治的方法，富血小板血浆（PRP）已成为治疗 AA 等非鳞屑性脱发的一种新方法。本研究旨在比较外用莫米松加 PRP 与单纯外用莫米松治疗 AA 患者的疗效和不良反应。研究方法本研究共对 100 例经临床诊断的 AA 患者进行了研究。A 组患者接受皮内注射自体 PRP，每 3 周一次，同时每天外用 0.1% 吗美他松乳膏，共 12 周。B 组患者每天一次外用 0.1%莫米松乳膏涂抹患处，持续 12 周。结果A 组基线 SALT 评分为（6.05±5.36）分，B 组为（6.62±4.39）分。20 周后，A 组的平均 SALT 分数降至 0.94±1.69，B 组降至 2.19±1.76。A 组和 B 组分别有 12 名和 5 名患者的疗效极佳。A 组有 10 名患者（20%）出现疼痛等轻微副作用，B 组有 2 名患者出现萎缩：这是有史以来第一项评估局部注射 PRP 额外益处的研究。研究发现，在治疗 AA 时，在局部使用莫米松 0.1%乳膏的同时加入局部 PRP，比单独使用局部莫米松具有更高的疗效和更早的改善。
{"title":"Study of effect of topical mometasone with intralesional platelet-rich plasma versus topical mometasone alone in the treatment of alopecia areata","authors":"Monika Kulhari, Mohammad Adil, Iti Varshney, S. Amin","doi":"10.18203/issn.2455-4529.intjresdermatol20233875","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20233875","url":null,"abstract":"Background: Alopecia areata (AA) is an autoimmune disorder and exhibits non scarring alopecia. Currently, there is no definitive cure, platelet rich plasma (PRP) has emerged as a newer modality for non-cicatricial alopecias such as AA. This study was conducted to compare the efficacy and adverse effects of topical mometasone with PRP versus topical mometasone alone in the treatment of patients of AA. Methods: This study was conducted on a total of 100 clinically diagnosed cases of AA. Patients in group A were subjected to intradermal injection of autologous PRP every 3 weeks along with topical mometasone cream 0.1% daily for 12 weeks. Group B was treated with topical mometasone cream 0.1% once a day locally over affected site for 12 weeks. Results: Baseline SALT score of group A was 6.05±5.36 while that of group B was 6.62±4.39. The mean SALT score of group A declined to 0.94±1.69 and that of group B 2.19±1.76 over a period of 20 weeks. Excellent response was observed by 12 and 5 patients of group A and group B respectively. Minor side effects like pain was seen in 10 patients (20%) in group A, while atrophy was seen in 2 patients of group B. Conclusions: This is the first ever study evaluating the additional benefit of intralesional PRP. In this study, it was found that adding intralesional PRP with topical mometasone 0.1% cream has higher efficacy and early improvement than topical mometasone alone, in the treatment of AA.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"78 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139165163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Hair loss, commonly associated with genetics, hormones, or health conditions, is prevalent. Dandruff, resulting in flaky scalp skin, is also widespread. Ayurvedic herbal remedies show potential for addressing these hair issues. This clinical trial assesses the efficacy and safety of an ayurvedic hair oil in healthy adults with hair loss (alopecia). The aim is to evaluate its purported benefits in reducing hair fall, stimulating hair growth and alleviating scalp dandruff. Methods: This 8-week study involved 30 subjects with hair fall. After obtaining subject consent, a test hair oil was applied topically. Assessments included evaluating hair-fall, scalp dandruff, hair-growth rate, density, and thickness. Ayurvedic assessment determined hair type. Phototrichogram, pluck-test measured growth, with endpoints including pull-test, combing-test, dermatological evaluation, and subjective questionnaires. Statistical analysis used R software (Version: 4.1.2). Results: The study revealed significant therapeutic efficacy. The mean hair-growth rate increased significantly by 227µm/day (79.92±69.31%) over 8 weeks (p<0.01). Hair-fall decreased by 63.49±21.44%, from 97 to 31 hairs. Hair-thickness and density improved by 34.26±16.36% (p<0.01) and 39.82±34.3% (p<0.01) respectively. Scalp dandruff showed a reduction of 76.33±15.95% (p<0.01). The A:T ratio shifted positively from 3:1 to 5:1, indicating an increase in hairs in the anagen phase. No adverse effects were observed. Conclusions: Consistent use of 'moha: 5-in-1' hair oil over 8 weeks was well-tolerated and found effective. It significantly decreased hair fall, promoted hair growth, and improved scalp health by reducing dandruff. This confirms its safety and efficacy among study participants, establishing it as suitable choice for holistic daily hair care.
{"title":"A clinical investigation on the safety and effectiveness of an ayurvedic hair oil in controlling hair fall (khalitya) in healthy adult human subjects: a study on hair fall management","authors":"Manisha Mishra, Nayan Patel, Apeksha Merja, Sherry Shah, Maheshvari Patel","doi":"10.18203/issn.2455-4529.intjresdermatol20233850","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20233850","url":null,"abstract":"Background: Hair loss, commonly associated with genetics, hormones, or health conditions, is prevalent. Dandruff, resulting in flaky scalp skin, is also widespread. Ayurvedic herbal remedies show potential for addressing these hair issues. This clinical trial assesses the efficacy and safety of an ayurvedic hair oil in healthy adults with hair loss (alopecia). The aim is to evaluate its purported benefits in reducing hair fall, stimulating hair growth and alleviating scalp dandruff.\u0000Methods: This 8-week study involved 30 subjects with hair fall. After obtaining subject consent, a test hair oil was applied topically. Assessments included evaluating hair-fall, scalp dandruff, hair-growth rate, density, and thickness. Ayurvedic assessment determined hair type. Phototrichogram, pluck-test measured growth, with endpoints including pull-test, combing-test, dermatological evaluation, and subjective questionnaires. Statistical analysis used R software (Version: 4.1.2).\u0000Results: The study revealed significant therapeutic efficacy. The mean hair-growth rate increased significantly by 227µm/day (79.92±69.31%) over 8 weeks (p<0.01). Hair-fall decreased by 63.49±21.44%, from 97 to 31 hairs. Hair-thickness and density improved by 34.26±16.36% (p<0.01) and 39.82±34.3% (p<0.01) respectively. Scalp dandruff showed a reduction of 76.33±15.95% (p<0.01). The A:T ratio shifted positively from 3:1 to 5:1, indicating an increase in hairs in the anagen phase. No adverse effects were observed.\u0000Conclusions: Consistent use of 'moha: 5-in-1' hair oil over 8 weeks was well-tolerated and found effective. It significantly decreased hair fall, promoted hair growth, and improved scalp health by reducing dandruff. This confirms its safety and efficacy among study participants, establishing it as suitable choice for holistic daily hair care.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"25 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138956600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-25DOI: 10.18203/issn.2455-4529.intjresdermatol20233177
Adithyan Panchatsharam, Revathy Sundaramurthy
Background: Several cross-sectional studies in the form of school surveys and studies on paediatric patients visiting dermatology OPD in tertiary care hospital has been conducted in the last three decades. This study was conducted to note the pattern of paediatric dermatoses and also to compare the difference in disease pattern with other studies conducted in southern India in last decade. Methods: A retrospective cross-sectional study was conducted at the Dermatology department of MVJ teaching hospital to determine the pattern of pediatric dermatoses from May 2021 to October 2021 after obtaining institutional ethics committee clearance. Cases under the age of 18 years were included in the study. Cases with age above 18 years, incomplete data, dermatoses where diagnosis was uncertain were excluded from the study. A total of 150 children were included in the study. The results were entered and tabulated in MS-excel sheet and descriptive analysis was done. Results: 150 children were included in the study.36 types of dermatoses were noted overall. Eczematous diseases (32.7%) contributed to the maximum followed by infections and infestations (25.3%). The most frequent dermatoses found were Atopic dermatoses (10%), pityriasis alba (8.6%), scabies (8.6%), Acne vulgaris (8.6%). Eczematous diseases and hypersensitivity disorders were noted to have increased frequency when compared to other studies in last one decade Conclusions: Rising trend in atopic dermatitis has been noted which might be due to changing environmental factors and also due to better recognition of condition by physicians in last one decade. With respect to spectrum of skin infections and infestations not much of difference is appreciated when compared to previous studies
{"title":"Pattern of pediatric dermatoses in a tertiary hospital in South India","authors":"Adithyan Panchatsharam, Revathy Sundaramurthy","doi":"10.18203/issn.2455-4529.intjresdermatol20233177","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20233177","url":null,"abstract":"Background: Several cross-sectional studies in the form of school surveys and studies on paediatric patients visiting dermatology OPD in tertiary care hospital has been conducted in the last three decades. This study was conducted to note the pattern of paediatric dermatoses and also to compare the difference in disease pattern with other studies conducted in southern India in last decade. Methods: A retrospective cross-sectional study was conducted at the Dermatology department of MVJ teaching hospital to determine the pattern of pediatric dermatoses from May 2021 to October 2021 after obtaining institutional ethics committee clearance. Cases under the age of 18 years were included in the study. Cases with age above 18 years, incomplete data, dermatoses where diagnosis was uncertain were excluded from the study. A total of 150 children were included in the study. The results were entered and tabulated in MS-excel sheet and descriptive analysis was done. Results: 150 children were included in the study.36 types of dermatoses were noted overall. Eczematous diseases (32.7%) contributed to the maximum followed by infections and infestations (25.3%). The most frequent dermatoses found were Atopic dermatoses (10%), pityriasis alba (8.6%), scabies (8.6%), Acne vulgaris (8.6%). Eczematous diseases and hypersensitivity disorders were noted to have increased frequency when compared to other studies in last one decade Conclusions: Rising trend in atopic dermatitis has been noted which might be due to changing environmental factors and also due to better recognition of condition by physicians in last one decade. With respect to spectrum of skin infections and infestations not much of difference is appreciated when compared to previous studies","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"36 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134974286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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