Pub Date : 2024-03-01DOI: 10.32402/dovkil2024.01.011
O. Mykhaylenko
Numerous clinical studies have established that smoking has a harmful effect on human health including diabetes mellitus. The aim is to assess the peculiarities of health changes among citizens of Ukraine under the influence of a harmful factor, thanks to a simultaneous questionnaire and in-depth medical examination for further improvement of diagnostics and stratification of the degree of risk of developing various diseases and timely appointment of adequate therapy. Materials and methods. Among the laboratory tests, the following were determined: blood glucose level, IR marker – Нoma index, which were determined on an empty stomach, in the morning, the last meal was 12 hours before blood donation. Determination of the results of indicators was carried out using chemiluminescence analysis. Reagents: Roche Diagnostics (Switzerland). Analyzer Cobas 8000 | ProCobas 6000 |Cobas 411 (Switzerland). Statistical data processing was carried out using a software package. The relationship between quantitative indicators was carried out using Pearson’s correlation analysis (r ). Statistical probability was estimated by the parametric Student’s t-test. The difference was considered probable at p<0.05. The relationship between quantitative and rank indicators was carried out using variance analysis, the Fisher coefficient (F). Results. A register of respondents was created - adults (men and women) who were under the influence of a modified factor that is a trigger for the prevalence of such conditions as insulin resistance and hyperglycemia; prediabetes, diabetes, cardiovascular diseases (CVD), etc. Answers related to smoking were converted from rank indicators into quantitative indicators. Through prospective observations, during the research, it was established that 47.5% consumed tobacco products in one form or another (not often - 15%, moderately - 12.5%, quite often - 7.5%, extremely often - 12.5%). A reliable relationship between quantitative indicators was also confirmed using Pearson’s correlation analysis (rs) between the level of glucose and the IR Нoma index (r=0.444, p=0.004), which once again confirms that the IR Нoma index increases due to the increase in glucose, and the prerequisite for this can be serve: age-related changes in the body’s hormonal balance, a passive lifestyle, weight gain and the presence of a bad habit, namely smoking. For the first time, the relationship between quantitative and rank indicators was established using variance analysis: between the level of glucose and smoking (F=2.757; p=0.043), between the level of IR Нoma index and smoking. Conclusions. As a result of the implementation of the pilot project, it was established that 47.5% of respondents smoke, of which 7.5% very often, 12.5% extremely often. In the course of the implementation of the pilot project, a register of respondents participating in the study was created. The relationship between quantitative indicators was also confirmed, one of which is the relatio
大量临床研究证实，吸烟对人体健康（包括糖尿病）有害。本研究的目的是通过同时进行问卷调查和深入体检，评估乌克兰公民在有害因素影响下健康变化的特殊性，从而进一步改进诊断，对各种疾病的发病风险程度进行分层，并及时采取适当的治疗措施。材料和方法。在实验室检查中，测定了以下指标：血糖水平、红外标志物--Нoma 指数，这些指标在献血前 12 小时空腹测定。指标结果的测定采用化学发光分析法。试剂罗氏诊断公司（瑞士）。分析仪：Cobas 8000 | ProCobas 6000 |Cobas 411（瑞士）。使用软件包进行数据统计处理。定量指标之间的关系采用皮尔逊相关分析法（r ）。统计概率通过参数化的学生 t 检验进行估计。当 P<0.05 时，差异被认为是可能的。定量指标和等级指标之间的关系采用方差分析和费舍尔系数（F）。结果对受访者进行了登记，他们都是成年人（男性和女性），受胰岛素抵抗和高血糖、糖尿病前期、糖尿病、心血管疾病（CVD）等疾病的诱发因素影响。与吸烟有关的答案由等级指标转换为量化指标。研究期间，通过前瞻性观察，确定 47.5%的人以某种形式消费烟草产品（不经常--15%，一般--12.5%，比较经常--7.5%，非常经常--12.5%）。血糖水平与 IR Нoma 指数之间的皮尔逊相关分析（rs）（r=0.444，p=0.004）也证实了定量指标之间的可靠关系，这再次证实 IR Нoma 指数会随着血糖的升高而升高，其前提条件是：与年龄有关的体内激素平衡的变化、被动的生活方式、体重增加以及存在不良习惯，即吸烟。利用方差分析首次确定了定量指标和等级指标之间的关系：葡萄糖水平与吸烟之间的关系（F=2.757；P=0.043），红外Нoma 指数水平与吸烟之间的关系。结论试点项目实施的结果表明，47.5% 的受访者吸烟，其中 7.5%的受访者非常经常吸烟，12.5%的受访者非常经常吸烟。在试点项目实施过程中，对参与研究的受访者进行了登记。定量指标之间的关系也得到了证实，其中之一是健康状况与吸烟之间的关系（rs=0.428；p=0.005）。首次使用方差分析研究了定量指标与等级指标之间的关系：血糖水平与吸烟之间的关系（F=2.757；P=0.043）。由于测量尺度的转换，首次确定了红外水平与Нoma 退火指数之间的依赖关系。
{"title":"Correlational analysis of the dependence of the health of the population of Ukraine on smoking as a factor in the development of diseases","authors":"O. Mykhaylenko","doi":"10.32402/dovkil2024.01.011","DOIUrl":"https://doi.org/10.32402/dovkil2024.01.011","url":null,"abstract":"Numerous clinical studies have established that smoking has a harmful effect on human health including diabetes mellitus. The aim is to assess the peculiarities of health changes among citizens of Ukraine under the influence of a harmful factor, thanks to a simultaneous questionnaire and in-depth medical examination for further improvement of diagnostics and stratification of the degree of risk of developing various diseases and timely appointment of adequate therapy. Materials and methods. Among the laboratory tests, the following were determined: blood glucose level, IR marker – Нoma index, which were determined on an empty stomach, in the morning, the last meal was 12 hours before blood donation. Determination of the results of indicators was carried out using chemiluminescence analysis. Reagents: Roche Diagnostics (Switzerland). Analyzer Cobas 8000 | ProCobas 6000 |Cobas 411 (Switzerland). Statistical data processing was carried out using a software package. The relationship between quantitative indicators was carried out using Pearson’s correlation analysis (r ). Statistical probability was estimated by the parametric Student’s t-test. The difference was considered probable at p<0.05. The relationship between quantitative and rank indicators was carried out using variance analysis, the Fisher coefficient (F). Results. A register of respondents was created - adults (men and women) who were under the influence of a modified factor that is a trigger for the prevalence of such conditions as insulin resistance and hyperglycemia; prediabetes, diabetes, cardiovascular diseases (CVD), etc. Answers related to smoking were converted from rank indicators into quantitative indicators. Through prospective observations, during the research, it was established that 47.5% consumed tobacco products in one form or another (not often - 15%, moderately - 12.5%, quite often - 7.5%, extremely often - 12.5%). A reliable relationship between quantitative indicators was also confirmed using Pearson’s correlation analysis (rs) between the level of glucose and the IR Нoma index (r=0.444, p=0.004), which once again confirms that the IR Нoma index increases due to the increase in glucose, and the prerequisite for this can be serve: age-related changes in the body’s hormonal balance, a passive lifestyle, weight gain and the presence of a bad habit, namely smoking. For the first time, the relationship between quantitative and rank indicators was established using variance analysis: between the level of glucose and smoking (F=2.757; p=0.043), between the level of IR Нoma index and smoking. Conclusions. As a result of the implementation of the pilot project, it was established that 47.5% of respondents smoke, of which 7.5% very often, 12.5% extremely often. In the course of the implementation of the pilot project, a register of respondents participating in the study was created. The relationship between quantitative indicators was also confirmed, one of which is the relatio","PeriodicalId":144023,"journal":{"name":"Environment & Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140271860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Environmental Obesogens and Their Perturbations in Lipid Metabolism","authors":"Xiaoyun Wang, Zhendong Sun, Qian S. Liu, Qunfang Zhou, Guibin Jiang","doi":"10.1021/envhealth.3c00202","DOIUrl":"https://doi.org/10.1021/envhealth.3c00202","url":null,"abstract":"","PeriodicalId":144023,"journal":{"name":"Environment & Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139840887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-05DOI: 10.1021/envhealth.3c00155
Duo Zhang, Xiang Liu, J. Tu, Qinru Xiao, Linjiang Han, Jinfeng Fu, Junye Bian, Ruyue Zhang, Jimei Chen, Yijia Shao, Shaoyou Lu
{"title":"Mediating Role of Glucose-Lipid Metabolism in the Association between the Increased Risk of Coronary Heart Disease and Exposure to Organophosphate Esters, Phthalates, and Polycyclic Aromatic Hydrocarbons","authors":"Duo Zhang, Xiang Liu, J. Tu, Qinru Xiao, Linjiang Han, Jinfeng Fu, Junye Bian, Ruyue Zhang, Jimei Chen, Yijia Shao, Shaoyou Lu","doi":"10.1021/envhealth.3c00155","DOIUrl":"https://doi.org/10.1021/envhealth.3c00155","url":null,"abstract":"","PeriodicalId":144023,"journal":{"name":"Environment & Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139803714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.32402/dovkil2023.04.046
V. Babii, D. Hlavachek
The aim of work is to analyze the current state of the use of rodenticides to control rodents in various areas of human activity, as well as prospects for improving rodenticides. Materials and methods of research: bibliosemantic, bibliographic and analytical methods of research. The research materials were foreign research articles. Research results and discussion. Various methods are used around the world to directly control rodent populations or reduce the damage caused by them. These methods include physical (traps, barriers), chemical (toxic baits, fumigants, repellents), biological/cultural (resistant plants, crop type, sanitation, habitat manipulation). The use of chemicals for rodent control has been practiced for almost a century and is common today. Most rodenticides used today are anticoagulants, which prevent blood clotting. The biological effectiveness of rodent control is determined not only by the toxicity of the rodenticide drug, but also by many other conditions that are closely related to the biological characteristics of the development of rodents. All rodenticides are enteric drugs. The mechanism of toxic effects of drugs in this group is different and is determined by the active substances on the basis of which they are made. The article presents various approaches to the classification of rodenticides and describes the ways of their impact on target and non-target animal species. The risk and toxicity of the most commonly used rodenticides, which have different chemical compositions and can have a wide range of clinical manifestations, are also assessed. The amount of bait that constitutes a lethal dose depends on the toxicity of the poison and the severity of the person. Conclusion: among the prospects for the further use of rodenticides, the leading place is occupied by the development of an “ideal rodenticide”, highly toxic to rodents in small quantities, non-toxic to non-target species and allows to avoid fear of the bait in rodents and, accordingly, rejection of it.
{"title":"Rodenticides as the basis of deratisation: general characteristics, classification, mechanisms of action, features of application and prospects (review of literature data)","authors":"V. Babii, D. Hlavachek","doi":"10.32402/dovkil2023.04.046","DOIUrl":"https://doi.org/10.32402/dovkil2023.04.046","url":null,"abstract":"The aim of work is to analyze the current state of the use of rodenticides to control rodents in various areas of human activity, as well as prospects for improving rodenticides. Materials and methods of research: bibliosemantic, bibliographic and analytical methods of research. The research materials were foreign research articles. Research results and discussion. Various methods are used around the world to directly control rodent populations or reduce the damage caused by them. These methods include physical (traps, barriers), chemical (toxic baits, fumigants, repellents), biological/cultural (resistant plants, crop type, sanitation, habitat manipulation). The use of chemicals for rodent control has been practiced for almost a century and is common today. Most rodenticides used today are anticoagulants, which prevent blood clotting. The biological effectiveness of rodent control is determined not only by the toxicity of the rodenticide drug, but also by many other conditions that are closely related to the biological characteristics of the development of rodents. All rodenticides are enteric drugs. The mechanism of toxic effects of drugs in this group is different and is determined by the active substances on the basis of which they are made. The article presents various approaches to the classification of rodenticides and describes the ways of their impact on target and non-target animal species. The risk and toxicity of the most commonly used rodenticides, which have different chemical compositions and can have a wide range of clinical manifestations, are also assessed. The amount of bait that constitutes a lethal dose depends on the toxicity of the poison and the severity of the person. Conclusion: among the prospects for the further use of rodenticides, the leading place is occupied by the development of an “ideal rodenticide”, highly toxic to rodents in small quantities, non-toxic to non-target species and allows to avoid fear of the bait in rodents and, accordingly, rejection of it.","PeriodicalId":144023,"journal":{"name":"Environment & Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139015777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.32402/dovkil2023.04.055
O. V. Surmasheva, Y. Zheludenko, O.V. Molchanets, Mykhailo Rosada, О.О. Polka, S.P. Zadkova
The aim: industrial wastewater microbiological monitoring and its effect on the drainage water condition. Purpose: microbiological monitoring of industrial wastewater and its impact on the state of surface waters. Materials and methods: wastewater quality evaluation was performed according to the parameters: the lactose-positive coliforms (LPC) count, the coli index, coliphages count and the pathogenic enterobacteria presence. Results: wastewater (WW) treated with full biological treatment and disinfection, UV radiation, chlorination and the cleansing structures use was studied. Industrial WW samples met the 1-2 quality class requirements. 7 food processing wastewater samples did not meet the discharge into an open water requirements in terms of LCP count, which was in the range from 2300 CFU/dm3 to 46000 CFU/dm3, it indicates water fecal pollution. At the same time, according to the coliphages count, these samples belonged to the 2nd quality class. Surface water samples comparative analysis before and after the industrial wastewater discharge shows that the investigated wastewater discharge did not lead to surface watercourse microbiological contamination. Conclusions: according to the 41 industrial wastewater reuse samples microbiological quality monitoring results for the period January 2021-June 2023, 34 WW samples were met the 1-2 quality class requirements, which indicates their satisfactory purification and the discharge possibility into an open water body. 7 samples did not meet the LCP number requirement, which indicates poor-quality purification and their fecal contamination. It was established that the surface watercourse before and after the reuse wastewater discharge, according to the LCP count, the coli index, coliphages count belong to the 1-2 quality class. The investigated industrial wastewater discharge did not exceed the allowance allocation and did not lead to surface waters microbiological contamination.
{"title":"Microbiological assessment of wastewater of industrial enterprises in Kyiv and the Kyiv region","authors":"O. V. Surmasheva, Y. Zheludenko, O.V. Molchanets, Mykhailo Rosada, О.О. Polka, S.P. Zadkova","doi":"10.32402/dovkil2023.04.055","DOIUrl":"https://doi.org/10.32402/dovkil2023.04.055","url":null,"abstract":"The aim: industrial wastewater microbiological monitoring and its effect on the drainage water condition. Purpose: microbiological monitoring of industrial wastewater and its impact on the state of surface waters. Materials and methods: wastewater quality evaluation was performed according to the parameters: the lactose-positive coliforms (LPC) count, the coli index, coliphages count and the pathogenic enterobacteria presence. Results: wastewater (WW) treated with full biological treatment and disinfection, UV radiation, chlorination and the cleansing structures use was studied. Industrial WW samples met the 1-2 quality class requirements. 7 food processing wastewater samples did not meet the discharge into an open water requirements in terms of LCP count, which was in the range from 2300 CFU/dm3 to 46000 CFU/dm3, it indicates water fecal pollution. At the same time, according to the coliphages count, these samples belonged to the 2nd quality class. Surface water samples comparative analysis before and after the industrial wastewater discharge shows that the investigated wastewater discharge did not lead to surface watercourse microbiological contamination. Conclusions: according to the 41 industrial wastewater reuse samples microbiological quality monitoring results for the period January 2021-June 2023, 34 WW samples were met the 1-2 quality class requirements, which indicates their satisfactory purification and the discharge possibility into an open water body. 7 samples did not meet the LCP number requirement, which indicates poor-quality purification and their fecal contamination. It was established that the surface watercourse before and after the reuse wastewater discharge, according to the LCP count, the coli index, coliphages count belong to the 1-2 quality class. The investigated industrial wastewater discharge did not exceed the allowance allocation and did not lead to surface waters microbiological contamination.","PeriodicalId":144023,"journal":{"name":"Environment & Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139020897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.32402/dovkil2023.04.016
A.V. Basanets, V. Hvozdetskyi
Introduction: In connection with the reintegration processes of Ukraine's accession to the European Union, the system of recognition, registration, accounting of occupational diseases and the corresponding legislative and methodological base must be adapted to international requirements and recommendations. The level of occupational morbidity in the country does not reflect its real state due to many social and medical reasons. The purpose of the study: analysis of the new edition of the List of occupational diseases and instructions for its use by the ILO in 2022, comparison of its main provisions with a similar list in Ukraine with the aim of the upcoming adaptation of the of occupational diseases registration system in Ukraine to the requirements of the European Union in connection with the process of European integration. Materials and methods: Analytical review of scientific publications was performed using databases of scientific libraries Pub Med, Medline and text databases of scientific publishing houses Pub Med, Central, BMJ group and other VIP databases. The main legislative documents of Ukraine and the International Labor Organization regulating the process of occupational diseases recognizing are analyzed. System and content analysis methods are used. Results: A comparative analysis of materials on the occupational diseases recognition according to the ILO recommendations, as well as similar domestic documents, revealed the unity of general principles. However, at the same time, significant differences were found in the formation of the list of occupational diseases. The ILO list of occupational diseases provides more detailed information on the causative agent, data on occupational exposure to hazardous substances, features of etiopathogenesis, toxicological profile for chemicals, and biological mechanisms for physical and biological factors, main health effects and diagnostic criteria, as well as measures of occupational diseases prevention. This information is not included in the domestic list of occupational diseases and instructions for its use, which significantly limits the possibilities for diagnosing and objectifying of occupational diseases. Considering Ukraine's preparations for joining the European Union, it is obvious that it is necessary to revise domestic legislation regarding the occupational diseases recognition in accordance with international standards and ILO recommendations.
{"title":"Analysis of the national list of occupational diseases in accordance with the recommendations of the ILO in 2022: integration into European legislation","authors":"A.V. Basanets, V. Hvozdetskyi","doi":"10.32402/dovkil2023.04.016","DOIUrl":"https://doi.org/10.32402/dovkil2023.04.016","url":null,"abstract":"Introduction: In connection with the reintegration processes of Ukraine's accession to the European Union, the system of recognition, registration, accounting of occupational diseases and the corresponding legislative and methodological base must be adapted to international requirements and recommendations. The level of occupational morbidity in the country does not reflect its real state due to many social and medical reasons. The purpose of the study: analysis of the new edition of the List of occupational diseases and instructions for its use by the ILO in 2022, comparison of its main provisions with a similar list in Ukraine with the aim of the upcoming adaptation of the of occupational diseases registration system in Ukraine to the requirements of the European Union in connection with the process of European integration. Materials and methods: Analytical review of scientific publications was performed using databases of scientific libraries Pub Med, Medline and text databases of scientific publishing houses Pub Med, Central, BMJ group and other VIP databases. The main legislative documents of Ukraine and the International Labor Organization regulating the process of occupational diseases recognizing are analyzed. System and content analysis methods are used. Results: A comparative analysis of materials on the occupational diseases recognition according to the ILO recommendations, as well as similar domestic documents, revealed the unity of general principles. However, at the same time, significant differences were found in the formation of the list of occupational diseases. The ILO list of occupational diseases provides more detailed information on the causative agent, data on occupational exposure to hazardous substances, features of etiopathogenesis, toxicological profile for chemicals, and biological mechanisms for physical and biological factors, main health effects and diagnostic criteria, as well as measures of occupational diseases prevention. This information is not included in the domestic list of occupational diseases and instructions for its use, which significantly limits the possibilities for diagnosing and objectifying of occupational diseases. Considering Ukraine's preparations for joining the European Union, it is obvious that it is necessary to revise domestic legislation regarding the occupational diseases recognition in accordance with international standards and ILO recommendations.","PeriodicalId":144023,"journal":{"name":"Environment & Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139016498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.32402/dovkil2023.04.023
I.O. Chernychenko, O.M. Lytvychenko, V. Babii, O.Ye. Kondratenko, D. Hlavachek
The purpose of this work was to assess the safety of domestic (hygienic) standards for carcinogenic substances in the atmospheric air of populated areas and determine the concentration level corresponding to the acceptable risk indicator. Materials and methods. Bibliosemantic, bibliographic and hygienic research methods were used in this research. The results were obtained based on the collection and analysis of data on chemical carcinogenic compounds dangerous to humans, based on materials from international Directives, domestic regulatory frameworks and the IARC database. To assess the danger of individual substances and hygienic regulatory levels, risk indicators were determined according to recommended methodological documents. Indicators of reference concentrations for carcinogenic substances standardized in Ukraine were taken from data of the integrated risk information system (IRIS) US EPA. Results and discussion: the studies conducted indicate the need to revise the hygienic standards for carcinogenic substances included in the domestic regulatory framework for the atmospheric air of populated areas. The current standards for the most part exceed the level of acceptable or acceptable risk of probable cancer development among the population and those employed in production. This issue can be resolved by using an accelerated methodology, which is based on the calculation of the dose-risk scale. Accepted hygienic standards for the indicator of carcinogenic risk should be considered as annual averages for the atmospheric air of populated areas, and the current average daily concentrations according to international recommendations should be aimed at preventing acute exposure to chemical carcinogens within 24 hours and manifest themselves over a period of about 14 days. Conclusion: sanitary (hygienic) standards for carcinogenic substances in the air, included in the domestic bases, overwhelmingly exceed the level of permissible (acceptable) risk of cancer development and do not ensure safety for the population and persons involved in production and require revision in accordance with the requirements of the EU countries and the USA. It is proposed to resolve this issue using an accelerated methodology, which is based on the calculation of the dose-risk relationship (scale).
{"title":"Compliance determination of domestic base of hygienic standards for carcinogenic substances in the atmospheric air of populated areas with EU requirements","authors":"I.O. Chernychenko, O.M. Lytvychenko, V. Babii, O.Ye. Kondratenko, D. Hlavachek","doi":"10.32402/dovkil2023.04.023","DOIUrl":"https://doi.org/10.32402/dovkil2023.04.023","url":null,"abstract":"The purpose of this work was to assess the safety of domestic (hygienic) standards for carcinogenic substances in the atmospheric air of populated areas and determine the concentration level corresponding to the acceptable risk indicator. Materials and methods. Bibliosemantic, bibliographic and hygienic research methods were used in this research. The results were obtained based on the collection and analysis of data on chemical carcinogenic compounds dangerous to humans, based on materials from international Directives, domestic regulatory frameworks and the IARC database. To assess the danger of individual substances and hygienic regulatory levels, risk indicators were determined according to recommended methodological documents. Indicators of reference concentrations for carcinogenic substances standardized in Ukraine were taken from data of the integrated risk information system (IRIS) US EPA. Results and discussion: the studies conducted indicate the need to revise the hygienic standards for carcinogenic substances included in the domestic regulatory framework for the atmospheric air of populated areas. The current standards for the most part exceed the level of acceptable or acceptable risk of probable cancer development among the population and those employed in production. This issue can be resolved by using an accelerated methodology, which is based on the calculation of the dose-risk scale. Accepted hygienic standards for the indicator of carcinogenic risk should be considered as annual averages for the atmospheric air of populated areas, and the current average daily concentrations according to international recommendations should be aimed at preventing acute exposure to chemical carcinogens within 24 hours and manifest themselves over a period of about 14 days. Conclusion: sanitary (hygienic) standards for carcinogenic substances in the air, included in the domestic bases, overwhelmingly exceed the level of permissible (acceptable) risk of cancer development and do not ensure safety for the population and persons involved in production and require revision in accordance with the requirements of the EU countries and the USA. It is proposed to resolve this issue using an accelerated methodology, which is based on the calculation of the dose-risk relationship (scale).","PeriodicalId":144023,"journal":{"name":"Environment & Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138991553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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