Pub Date : 2021-07-31DOI: 10.7897/2230-8407.1207150
M. Dhanasekaran, M. Udhayaeswaran, C. Dravid
Salvadora persica is a well-known medicinal plant which belongs to the family Salvadoraceae. It is commonly known as the Meswak tree. Calabash tree or Crescentia cujete tree belongs to the family of Bignoniaceae. It is also known as the gourd tree. These two plants have been studied by preliminary phytochemical and FTIR analysis. Data gathered on solvent extraction and preliminary phytochemical method suggested that the presence of primary and secondary metabolites in leaf tissue. Two solvents such as ethanol and aqueous are used here to reveal the phytocompounds and extend our work to find out the various functional groups present in these two plants through FTIR analysis was done. Spectrum of Salvadora persica showed 5 peaks that are 599.89, 654.86, 1409.06, 1431.24, 2930.96 and spectrum of Crescentia cujete showed that 13 peaks that are 470.65, 520.80, 630.75, 652.93, 776.38, 1060.89, 1155.41, 1248, 1321.30, 1431.24, 1527.69, 2860.56, 2924.21. The present study revealed that the functional groups of both plants, such as alcohols or phenols, alkanes, amines, esters or carboxylic acid or lactones, aldehyde or ketones, acetates and ethylene.
{"title":"PHYTOCHEMICAL INVESTIGATION, SPECTRUM ANALYSIS OF SALVADORA PERSICA AND CRESCENTIA CUJETE","authors":"M. Dhanasekaran, M. Udhayaeswaran, C. Dravid","doi":"10.7897/2230-8407.1207150","DOIUrl":"https://doi.org/10.7897/2230-8407.1207150","url":null,"abstract":"Salvadora persica is a well-known medicinal plant which belongs to the family Salvadoraceae. It is commonly known as the Meswak tree. Calabash tree or Crescentia cujete tree belongs to the family of Bignoniaceae. It is also known as the gourd tree. These two plants have been studied by preliminary phytochemical and FTIR analysis. Data gathered on solvent extraction and preliminary phytochemical method suggested that the presence of primary and secondary metabolites in leaf tissue. Two solvents such as ethanol and aqueous are used here to reveal the phytocompounds and extend our work to find out the various functional groups present in these two plants through FTIR analysis was done. Spectrum of Salvadora persica showed 5 peaks that are 599.89, 654.86, 1409.06, 1431.24, 2930.96 and spectrum of Crescentia cujete showed that 13 peaks that are 470.65, 520.80, 630.75, 652.93, 776.38, 1060.89, 1155.41, 1248, 1321.30, 1431.24, 1527.69, 2860.56, 2924.21. The present study revealed that the functional groups of both plants, such as alcohols or phenols, alkanes, amines, esters or carboxylic acid or lactones, aldehyde or ketones, acetates and ethylene.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89967092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-31DOI: 10.7897/2230-8407.1207149
M. Saifee, Pragati Bhaske, Reshma Toshniwal
The Simvastatin loaded microemulsion based gel was formulated and in-vitro evaluation was done for the treatment of diabetic wound healing. Simvastatin is BCS class II drug which promotes wound healing by increasing the production of vascular endothelial growth factor (VEGF). Microemulsions (MEs) are oil and water colloidal system stabilized by the mixture of surfactant and co-surfactant offering enhance skin permeability for both hydrophobic and hydrophilic drugs. At first, microemulsion (ME) was prepared by water titration method and the existence of ME region was determined using pseudo-ternary phase diagram. Formulations were prepared using oil (oleic acid), Tween 80 and PEG 400 as surfactant and co-surfactant. Optimization of formulation was done using 32 factorial designs. Carbopol 940 was used as gelling agent for preparing microemulsion gel. The formulations were evaluated for physical appearance globule size, polydispersity index, zeta potential, percent transmittance, thermodynamic stability, dilution test, drug content, and in vitro drug release. The optimized formulation of ME showed average globule size of 151 nm and the optimized ME gel had a homogeneous texture, showed good spreadability and in vitro drug release. The present study indicates the simvastatin loaded microemulsion gel could act as promising vehicle for topical drug delivery of drug for diabetic wound healing.
{"title":"FORMULATION AND EVALUATION OF SIMVASTATIN LOADED MICROEMULSION BASED GEL: IN VITRO CHARACTERIZATION","authors":"M. Saifee, Pragati Bhaske, Reshma Toshniwal","doi":"10.7897/2230-8407.1207149","DOIUrl":"https://doi.org/10.7897/2230-8407.1207149","url":null,"abstract":"The Simvastatin loaded microemulsion based gel was formulated and in-vitro evaluation was done for the treatment of diabetic wound healing. Simvastatin is BCS class II drug which promotes wound healing by increasing the production of vascular endothelial growth factor (VEGF). Microemulsions (MEs) are oil and water colloidal system stabilized by the mixture of surfactant and co-surfactant offering enhance skin permeability for both hydrophobic and hydrophilic drugs. At first, microemulsion (ME) was prepared by water titration method and the existence of ME region was determined using pseudo-ternary phase diagram. Formulations were prepared using oil (oleic acid), Tween 80 and PEG 400 as surfactant and co-surfactant. Optimization of formulation was done using 32 factorial designs. Carbopol 940 was used as gelling agent for preparing microemulsion gel. The formulations were evaluated for physical appearance globule size, polydispersity index, zeta potential, percent transmittance, thermodynamic stability, dilution test, drug content, and in vitro drug release. The optimized formulation of ME showed average globule size of 151 nm and the optimized ME gel had a homogeneous texture, showed good spreadability and in vitro drug release. The present study indicates the simvastatin loaded microemulsion gel could act as promising vehicle for topical drug delivery of drug for diabetic wound healing.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"77 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89722889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-31DOI: 10.7897/2230-8407.1207153
Pooja, P. Sharma, Viswanath Agrahari
Background: The aim of this study is to develop a liquid self-nano emulsifying drug delivery system for alverine (liquid-SNEDDS).Excipients in the alverine SNEDDS include Ethyl oleate as the oil phase, Tween 80 as a surfactant, and PEG600, Propylene glycol as a cosurfactant.The prepared eleven formulations of alverine SNEDDS were performed for emulsification time, percentage transmittance, particle size, drug release, in vitro dissolution and stability studies.The optimised alverine liquid SNEDDS formulation (D1) was studied for drug-excipient compatibility using infrared spectroscopy, as well as particle size, zeta potential, transmission electron microscopy, and stability. Alverine SNEDDS have a spherical shape with uniform particle distribution, according to their morphology. D1's optimised formulation's drug release percentage (96.6). The stability data revealed no discernible changes in drug content, emulsifying properties, drug release, or appearance. As a result, a potential SNEDDS formulation of alverine with improved solubility, dissolution rate, and bioavailability was developed.
{"title":"DESIGN AND EVALUATION OF SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEMS OF ALVERINE FOR ENHANCEMENT OF SOLUBILITY","authors":"Pooja, P. Sharma, Viswanath Agrahari","doi":"10.7897/2230-8407.1207153","DOIUrl":"https://doi.org/10.7897/2230-8407.1207153","url":null,"abstract":"Background: The aim of this study is to develop a liquid self-nano emulsifying drug delivery system for alverine (liquid-SNEDDS).Excipients in the alverine SNEDDS include Ethyl oleate as the oil phase, Tween 80 as a surfactant, and PEG600, Propylene glycol as a cosurfactant.The prepared eleven formulations of alverine SNEDDS were performed for emulsification time, percentage transmittance, particle size, drug release, in vitro dissolution and stability studies.The optimised alverine liquid SNEDDS formulation (D1) was studied for drug-excipient compatibility using infrared spectroscopy, as well as particle size, zeta potential, transmission electron microscopy, and stability. Alverine SNEDDS have a spherical shape with uniform particle distribution, according to their morphology. D1's optimised formulation's drug release percentage (96.6). The stability data revealed no discernible changes in drug content, emulsifying properties, drug release, or appearance. As a result, a potential SNEDDS formulation of alverine with improved solubility, dissolution rate, and bioavailability was developed.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86678671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-31DOI: 10.7897/2230-8407.1207151
S. Manikandan, Sabeerali Ansarali, M. Priyadharshini, G. Lakshmanan
Aim: Plectranthus (Linn) is a typical genus of the Indian flora. It had been used in the folk medicines for its several medicinal properties. In this study, there are twenty-five major biological compounds were selected from Plectranthus forskohlii, Plectranthus coleoides, Plectranthus rotundifolius and Plectranthus vettiveroides for molecular docking analysis and find out the active compounds against Diabetic, Cancer and Tuberculosis diseases. Materials and methods: Biological compounds of Plectranthus Species were identifying and investigated by GC-MS and the biological activities of these compounds were studied with virtual screening, ADMET analysis, Protein ligand interaction through molecular docking analysis. Results: Twenty-five major biological compounds were selected for virtual screening analysis to find out the drug likeness activity. Out of these twenty-five compounds nine compounds are drug likeness in nature. Based on the ADMET analysis, Thymol beta D-Glucoside showed the low toxicity level and it represent Lipinski rule of five. The molecular docking results of Thymol beta D-Glucoside interact with different target proteins used in the study showed the maximum docking energy was obtained against tuberculosis protein -10.1846kcal/mol followed by diabetic protein -10.8736kcal/mol and cancer protein -11.4109kcal/mol. Conclusion: Plectranthus amboinicus leaves showed significant anti-diabetic, anti-cancer, anti-tuberculosis activity when compared to other studied species such as Plectranthus forskohlii, Plectranthus coleoides, Plectranthus rotundifolius and Plectranthus vettiveroides.
目的:紫蕨属(Plectranthus, Linn)是一个典型的印度植物属。由于其多种药用特性，已被广泛应用于民间医药中。本研究选取了25个主要的生物化合物，对其进行分子对接分析，找出了抗糖尿病、癌症和结核病的活性化合物。材料与方法:采用气相色谱-质谱联用技术鉴定和研究了Plectranthus属植物的生物化合物，并通过虚拟筛选、ADMET分析和分子对接分析研究了这些化合物的生物活性。结果:选取25个主要生物化合物进行虚拟筛选分析，找出药物相似活性。在这25种化合物中，有9种化合物在性质上与药物相似。经ADMET分析，百里香酚- d -葡糖苷呈低毒性，符合利平斯基五法则。百里香酚- d -葡萄糖苷与不同靶蛋白相互作用的分子对接结果显示，对结核蛋白的对接能量最大，为-10.1846kcal/mol，其次是糖尿病蛋白-10.8736kcal/mol，癌症蛋白-11.4109kcal/mol。结论:与所研究的其他种属如山楂、桔梗、圆叶和草梗相比，羊角蕨叶具有显著的抗糖尿病、抗癌、抗结核活性。
{"title":"PHARMACOINFORMATICS APPROACH OF IDENTIFIED BIOLOGICAL COMPOUNDS FROM SELECTED PLECTRANTHUS (L.) SPECIES IN TAMIL NADU, INDIA: AN IN-SILICO APPROACH","authors":"S. Manikandan, Sabeerali Ansarali, M. Priyadharshini, G. Lakshmanan","doi":"10.7897/2230-8407.1207151","DOIUrl":"https://doi.org/10.7897/2230-8407.1207151","url":null,"abstract":"Aim: Plectranthus (Linn) is a typical genus of the Indian flora. It had been used in the folk medicines for its several medicinal properties. In this study, there are twenty-five major biological compounds were selected from Plectranthus forskohlii, Plectranthus coleoides, Plectranthus rotundifolius and Plectranthus vettiveroides for molecular docking analysis and find out the active compounds against Diabetic, Cancer and Tuberculosis diseases. Materials and methods: Biological compounds of Plectranthus Species were identifying and investigated by GC-MS and the biological activities of these compounds were studied with virtual screening, ADMET analysis, Protein ligand interaction through molecular docking analysis. Results: Twenty-five major biological compounds were selected for virtual screening analysis to find out the drug likeness activity. Out of these twenty-five compounds nine compounds are drug likeness in nature. Based on the ADMET analysis, Thymol beta D-Glucoside showed the low toxicity level and it represent Lipinski rule of five. The molecular docking results of Thymol beta D-Glucoside interact with different target proteins used in the study showed the maximum docking energy was obtained against tuberculosis protein -10.1846kcal/mol followed by diabetic protein -10.8736kcal/mol and cancer protein -11.4109kcal/mol. Conclusion: Plectranthus amboinicus leaves showed significant anti-diabetic, anti-cancer, anti-tuberculosis activity when compared to other studied species such as Plectranthus forskohlii, Plectranthus coleoides, Plectranthus rotundifolius and Plectranthus vettiveroides.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84914262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.7897/2230-8407.1206145
Nikunj Patadiya, Nikita Panchal, V. Vaghela
Enzymes play very important role in living organism as biocatalyst. They play vital role like secretion, metabolism, digestion, DNA functions, reproduction, conversation of molecules and many other functions of body. By inhibiting specific enzymes, we can cure numerous pathological conditions in humans like inhibiting HMG CoA reductase, we can decrease cholesterol synthesis which is very useful in atherosclerosis and also use for heart diseases. ACE inhibitors can reduce concentration of Angiotensin II and use to reduce blood pressure. Many of them use as pesticides and herbicides in agriculture field. The history says enzyme inhibitors are use as arrow poison and use to kill animals by developing paralysis in them. Using a digital technology scientist identified number of enzymes and their functions as well as their 3D structure. We can easily design their inhibitors and use as medicine to treat pathological conditions. So, enzyme inhibitors became first choice for medicinal chemist and scientist as a target and play extremely important role in future as medicinal compounds and became a safe option compared to other available options.
{"title":"A REVIEW ON ENZYME INHIBITORS","authors":"Nikunj Patadiya, Nikita Panchal, V. Vaghela","doi":"10.7897/2230-8407.1206145","DOIUrl":"https://doi.org/10.7897/2230-8407.1206145","url":null,"abstract":"Enzymes play very important role in living organism as biocatalyst. They play vital role like secretion, metabolism, digestion, DNA functions, reproduction, conversation of molecules and many other functions of body. By inhibiting specific enzymes, we can cure numerous pathological conditions in humans like inhibiting HMG CoA reductase, we can decrease cholesterol synthesis which is very useful in atherosclerosis and also use for heart diseases. ACE inhibitors can reduce concentration of Angiotensin II and use to reduce blood pressure. Many of them use as pesticides and herbicides in agriculture field. The history says enzyme inhibitors are use as arrow poison and use to kill animals by developing paralysis in them. Using a digital technology scientist identified number of enzymes and their functions as well as their 3D structure. We can easily design their inhibitors and use as medicine to treat pathological conditions. So, enzyme inhibitors became first choice for medicinal chemist and scientist as a target and play extremely important role in future as medicinal compounds and became a safe option compared to other available options.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86788035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.7897/2230-8407.1206140
A. Anku, K. Abbulu, S. Battu, Kalam Marryswarnalatha, T. S. Lakshmi
The present research was focused to prepare the formulation containing combination of Metformin and Curcumin to control diabetes-induced Alzheimer’s in elderly population with the utilization of Poloxamer P188 (8%), a thermoreversible gelling polymer, and mucoadhesive polymers such as Carbopol 940, Sodium alginate and HPMC K100 in varying concentrations (0.5%, 1%, 1.5% and 2% respectively) to improve the absorption of drugs by increasing the contact time with nasal mucosa. The in situ gel was prepared by cold method and administered via nasal route to deliver the drug directly to CNS by bypassing BBB and to improve patient compliance, nasal bioavailability of drugs by cumulative its nasal retention time in nasal mucosa. Total 12 nasal in situ gels were prepared and evaluated for in vitro studies and ex vivo drug diffusion studies (goat nasal mucosa) and results were found to be satisfactory. Moreover, histopathological studies revealed that the preparation was safe to be used on nasal mucosa of goat. The prepared nasal in situ gel is an effective alternative to conventional method and can be used to treat diabetes-induced Alzheimer’s disease.
{"title":"COMBINATION OF METFORMIN AND CURCUMIN THERMOREVERSIBLE NASAL IN SITU GEL FORMULATION AND IN VITRO-EX VIVO EVALUATION FOR DIABETES-INDUCED ALZHEIMER’S DISEASE","authors":"A. Anku, K. Abbulu, S. Battu, Kalam Marryswarnalatha, T. S. Lakshmi","doi":"10.7897/2230-8407.1206140","DOIUrl":"https://doi.org/10.7897/2230-8407.1206140","url":null,"abstract":"The present research was focused to prepare the formulation containing combination of Metformin and Curcumin to control diabetes-induced Alzheimer’s in elderly population with the utilization of Poloxamer P188 (8%), a thermoreversible gelling polymer, and mucoadhesive polymers such as Carbopol 940, Sodium alginate and HPMC K100 in varying concentrations (0.5%, 1%, 1.5% and 2% respectively) to improve the absorption of drugs by increasing the contact time with nasal mucosa. The in situ gel was prepared by cold method and administered via nasal route to deliver the drug directly to CNS by bypassing BBB and to improve patient compliance, nasal bioavailability of drugs by cumulative its nasal retention time in nasal mucosa. Total 12 nasal in situ gels were prepared and evaluated for in vitro studies and ex vivo drug diffusion studies (goat nasal mucosa) and results were found to be satisfactory. Moreover, histopathological studies revealed that the preparation was safe to be used on nasal mucosa of goat. The prepared nasal in situ gel is an effective alternative to conventional method and can be used to treat diabetes-induced Alzheimer’s disease.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78535167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.7897/2230-8407.1206146
S. Sagar, Monika Bisht
{"title":"A REVIEW ON PHYTOPHARMACOLOGY OF MEDICINAL PLANT: EUPHORBIA MILII DES MOUL","authors":"S. Sagar, Monika Bisht","doi":"10.7897/2230-8407.1206146","DOIUrl":"https://doi.org/10.7897/2230-8407.1206146","url":null,"abstract":"","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82160169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.7897/2230-8407.1206143
S. Chakravarty
The present study deals with the medicinal plants used by the people of 3 villages of Sorbhog area of Barpeta district, Assam to document the information related to various ethnomedicinal plants used by the villagers to cure various diseases. Intensive field work was carried out to obtain the detailed information on the plants and plant materials used by the villagers. In the present study a total of 33 medicinal plants belonging to 31 families were reported. These plants were used to cure various diseases like diabetes, jaundice, menstrual problems, stomach problems, infertility etc. The herbal medicines were prepared either from various parts of a single plant or multiple plants.
{"title":"ETHNOMEDICINAL PLANTS USED BY THE PEOPLE OF SORBHOG (BARNAGAR) AREA OF BARPETA DISTRICT, ASSAM, INDIA FOR VARIOUS AILMENTS","authors":"S. Chakravarty","doi":"10.7897/2230-8407.1206143","DOIUrl":"https://doi.org/10.7897/2230-8407.1206143","url":null,"abstract":"The present study deals with the medicinal plants used by the people of 3 villages of Sorbhog area of Barpeta district, Assam to document the information related to various ethnomedicinal plants used by the villagers to cure various diseases. Intensive field work was carried out to obtain the detailed information on the plants and plant materials used by the villagers. In the present study a total of 33 medicinal plants belonging to 31 families were reported. These plants were used to cure various diseases like diabetes, jaundice, menstrual problems, stomach problems, infertility etc. The herbal medicines were prepared either from various parts of a single plant or multiple plants.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82366627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.7897/2230-8407.1206139
S. Solanke, P. Kabra
Background: Cervical spondylosis is defined as degenerative changes occurring in the discs and cervical spine. Stating these changes is to be almost universal in the elderly. Cervical Spondylosis correlated with Manyagraha in Ayurvedic perspective. Aim: Aim of the study was to evaluate the effect of Erandamula Ghanavati and Anu Taila Nasya in Manyagraha. Methods: The Group in which Erandamula Ghanavati and Anutaila Nasya were given to patients was termed as Trial Group. The Group in which Panchatikta Ghrita Guggulu and Anutaila Nasya were given to patients was termed as Control Group. During this study 104 patients out of 150 were equally divided into Trial and Control Group by lottery method and comparative study was done. Statistical analysis was done using appropriate tests. Results: Erandamula Ghanavati along with Anu Taila Nasya has reduces symptoms of Manyagraha. Total effect of therapy is more in Trial group as compared to the Control Group. Discussion: As stated by Charak Erandamula is best Vatahara drug. Its Rasa, Virya and Vipak are helpful to alleviate Vata. Erandamula having Snigdha, Madhuraproperties is going to be beneficial in Dhatukshayajanya Vatavyadhi. Conclusion: Erandamula Ghanavati along with Anu Taila Nasya has beneficial for patients of Manyagraha.
{"title":"RANDOMIZED CONTROL TRIAL ON ERANDAMULA GHANAVATI WITH NASYA IN MANYAGRAHA WITH SPECIAL REFERENCE TO CERVICAL SPONDYLOSIS","authors":"S. Solanke, P. Kabra","doi":"10.7897/2230-8407.1206139","DOIUrl":"https://doi.org/10.7897/2230-8407.1206139","url":null,"abstract":"Background: Cervical spondylosis is defined as degenerative changes occurring in the discs and cervical spine. Stating these changes is to be almost universal in the elderly. Cervical Spondylosis correlated with Manyagraha in Ayurvedic perspective. Aim: Aim of the study was to evaluate the effect of Erandamula Ghanavati and Anu Taila Nasya in Manyagraha. Methods: The Group in which Erandamula Ghanavati and Anutaila Nasya were given to patients was termed as Trial Group. The Group in which Panchatikta Ghrita Guggulu and Anutaila Nasya were given to patients was termed as Control Group. During this study 104 patients out of 150 were equally divided into Trial and Control Group by lottery method and comparative study was done. Statistical analysis was done using appropriate tests. Results: Erandamula Ghanavati along with Anu Taila Nasya has reduces symptoms of Manyagraha. Total effect of therapy is more in Trial group as compared to the Control Group. Discussion: As stated by Charak Erandamula is best Vatahara drug. Its Rasa, Virya and Vipak are helpful to alleviate Vata. Erandamula having Snigdha, Madhuraproperties is going to be beneficial in Dhatukshayajanya Vatavyadhi. Conclusion: Erandamula Ghanavati along with Anu Taila Nasya has beneficial for patients of Manyagraha.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"496 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83888318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.7897/2230-8407.1206137
F. Sonbol, T. El-Banna, Norhan M. Sallam, Lamiaa A. Al-Madboly
Emergence of multi-drug resistant isolates of P. mirabilis and development of new resistant microbial phenotypes are growing and the outlook for the use of antimicrobial drugs in the future is still uncertain. Therefore, there is an increased demand for developing alternative strategies to conventional antibiotic therapy and to continue studies to develop new drugs, either synthetic or natural. In this study, 25 isolates of P. mirabilis were isolated from different clinical samples collected from different departments of Tanta University hospitals. All isolates were resistant to amoxicillin, azithromycin and tetracycline. A high incidence of resistance was also recorded for cefprozil (96%) and cefotaxime (80%). P. mirabilis isolates were moderately resistant to imipenem (64%), lomefloxacin (64%), ampicillin (60%), cefepime (60%) and ciprofloxacin (52%). However, the lowest incidence of resistance was recorded for amikacin (8%). All isolates showed MAR indices >0.2 and exhibited MDR profile. The antimicrobial activity of tea tree oil was evaluated using agar dilution method recording MIC50 value of 12.8 mg/ml. The effect of tea tree oil on the strong biofilm producer isolates with relatively wide swarming zone diameters was evaluated. Results obtained showed that tea tree oil (1/4 and 1/2 MIC) presented significant and dose-dependent inhibition in the biofilm production by the tested isolates of P. mirabilis by ≥50%. In addition, tea tree oil inhibited the swarming motility of P. mirabilis isolates in a dose-dependent manner. Therefore, tea tree oil could act as a potential source of alternative antimicrobials or as antipathogenic compound against MDR P.mirabilis.
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