Pub Date : 2021-06-30DOI: 10.7897/2230-8407.1206147
G. Swarnalatha, M. Poojitha
Medicinal plants have remained as a godsend for the current scientific advancements in terms of providing dealing with diseases. The current review provides the data regarding the medicinal plants which have been reported for hepatoprotective activity and which are to be reported for treating many disorders of humankind. The review covers the recent and updated data of medicinal plants to treat all kinds of hepatic disorders which are studied by inducing different methods. As the main metabolic center of human body liver plays a major role in disintegrating the drugs and also considered as the main center which can be affected easily due to toxicity and with the other disorders that can be elicited due to excess use of therapeutic drugs or due to mis use of drugs.
{"title":"REVIEW ON MEDICINAL PLANTS UNVEILING HEPATOPROTECTIVE ACTIVITY","authors":"G. Swarnalatha, M. Poojitha","doi":"10.7897/2230-8407.1206147","DOIUrl":"https://doi.org/10.7897/2230-8407.1206147","url":null,"abstract":"Medicinal plants have remained as a godsend for the current scientific advancements in terms of providing dealing with diseases. The current review provides the data regarding the medicinal plants which have been reported for hepatoprotective activity and which are to be reported for treating many disorders of humankind. The review covers the recent and updated data of medicinal plants to treat all kinds of hepatic disorders which are studied by inducing different methods. As the main metabolic center of human body liver plays a major role in disintegrating the drugs and also considered as the main center which can be affected easily due to toxicity and with the other disorders that can be elicited due to excess use of therapeutic drugs or due to mis use of drugs.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84481318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.7897/2230-8407.1206141
A. Anjum, A. Mosaddik, M. I. I. Wahed, . Md.EkramulHaque
The current study was carried out to investigate the sub-acute toxicity of 3-O--D-glucopyranosyl-(24)-ethylcholesta-5,22,25-triene, a steroidal glycoside isolated from the flowers of Alangium salviifolium Wang on Long Evan’s rat. After intra-peritoneal administration of the compound at a dose of 300 μg/rat/day for 14 consecutive days, no mortality or significant changes in body weight or behavior were observed. The blood samples of the rats were examined for hematological and biochemical parameters which were statistically insignificant when compared to that of the control group. All the vital organs showed normal histopathological architecture (heart, lungs, liver and kidney) in comparison to the control group. This preliminary investigation demonstrate that the compound is safe at dose of 300 μg/rat/day for 14 consecutive days. But acute, sub-chronic and chronic toxicity evaluations as well as clinical trials need to be done.
本实验研究了从丹参花中分离的甾体苷3-O-- d -glucopyranosyl-(24)-乙基胆碱-5,22,25-三烯对龙文大鼠的亚急性毒性作用。给药剂量为300 μg/大鼠/天，连续14天，大鼠无死亡，体重和行为无明显变化。取大鼠血样进行血液学和生化指标检查，与对照组比较，差异均无统计学意义。与对照组相比，各重要脏器(心、肺、肝、肾)病理结构正常。初步研究表明，该化合物在300 μg/大鼠/天的剂量下连续14天是安全的。但需要进行急性、亚慢性和慢性毒性评价以及临床试验。
{"title":"SUB-ACUTE TOXICITY OF A STEROIDAL GLYCOSIDE FROM THE FLOWERS OF ALANGIUM SALVIIFOLIUM WANG","authors":"A. Anjum, A. Mosaddik, M. I. I. Wahed, . Md.EkramulHaque","doi":"10.7897/2230-8407.1206141","DOIUrl":"https://doi.org/10.7897/2230-8407.1206141","url":null,"abstract":"The current study was carried out to investigate the sub-acute toxicity of 3-O--D-glucopyranosyl-(24)-ethylcholesta-5,22,25-triene, a steroidal glycoside isolated from the flowers of Alangium salviifolium Wang on Long Evan’s rat. After intra-peritoneal administration of the compound at a dose of 300 μg/rat/day for 14 consecutive days, no mortality or significant changes in body weight or behavior were observed. The blood samples of the rats were examined for hematological and biochemical parameters which were statistically insignificant when compared to that of the control group. All the vital organs showed normal histopathological architecture (heart, lungs, liver and kidney) in comparison to the control group. This preliminary investigation demonstrate that the compound is safe at dose of 300 μg/rat/day for 14 consecutive days. But acute, sub-chronic and chronic toxicity evaluations as well as clinical trials need to be done.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83321023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.7897/2230-8407.1206138
R. Tyagi, P. Sharma, D. Gupta
Background: This study aims to formulate, optimize and evaluate the osmotic tablet of cefixime. It improves the site specification and provides the controlled release of drug once – a – day through this drug delivery system. Cefixime assumes a significant part in dissolvability restricts other than dissolvable sort. It might increase the bioavailability of drugs by the preparation of the osmotic tablet. Method: The forming core tablet does a formulation of Controlled Porosity Osmotic Tablets (CP1 – CP9) using an ingredient like sodium chloride, PVP K30, Microcrystalline cellulose various ratios. The coating of the core tablet is done by Cellulose Acetate, PEG 400, with statistical ratios. Result: On depending upon the various evaluation parameters like hardness, diameter, friability, weight variation, content uniformity, In vitro release, CP9 formulation gave better consequence. The percentage of drug release is >95%. The optimized CP9 batch showed a maximum correlation of 0.992 with a zero-order drug release kinetic model. Conclusion: A controlled release formulation of cefixime based on osmotic technology, were developed. The release from the developed formulation was independent of pH and agitational intensity of the release media; the formulation fitted well into zero-order kinetics, indicating the release to be drug load independent. Drug release was directly proportional to the initial pore level but inversely related to the membrane weight. The release was inversely associated with the release media's osmotic pressure, confirming osmotic pumping as the central mechanism of release.
{"title":"FORMULATION AND EVALUATION OF DUAL-LAYERED OSMOTIC PUMP CONTROLLED-RELEASE TABLETS OF CEFIXIME","authors":"R. Tyagi, P. Sharma, D. Gupta","doi":"10.7897/2230-8407.1206138","DOIUrl":"https://doi.org/10.7897/2230-8407.1206138","url":null,"abstract":"Background: This study aims to formulate, optimize and evaluate the osmotic tablet of cefixime. It improves the site specification and provides the controlled release of drug once – a – day through this drug delivery system. Cefixime assumes a significant part in dissolvability restricts other than dissolvable sort. It might increase the bioavailability of drugs by the preparation of the osmotic tablet. Method: The forming core tablet does a formulation of Controlled Porosity Osmotic Tablets (CP1 – CP9) using an ingredient like sodium chloride, PVP K30, Microcrystalline cellulose various ratios. The coating of the core tablet is done by Cellulose Acetate, PEG 400, with statistical ratios. Result: On depending upon the various evaluation parameters like hardness, diameter, friability, weight variation, content uniformity, In vitro release, CP9 formulation gave better consequence. The percentage of drug release is >95%. The optimized CP9 batch showed a maximum correlation of 0.992 with a zero-order drug release kinetic model. Conclusion: A controlled release formulation of cefixime based on osmotic technology, were developed. The release from the developed formulation was independent of pH and agitational intensity of the release media; the formulation fitted well into zero-order kinetics, indicating the release to be drug load independent. Drug release was directly proportional to the initial pore level but inversely related to the membrane weight. The release was inversely associated with the release media's osmotic pressure, confirming osmotic pumping as the central mechanism of release.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90156390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.7897/2230-8407.1206144
Rajeev Sati, Monika Bisht
Holmskioldia sanguinea Retz. is a Sub-Himalayan plant that has been cultivated in the Americas, Europe, Indo-china, Asia-Pacific, and Southern Africa. It has been used traditionally to treat rheumatism and rheumatoid arthritis, dysentery, headaches, hypertension, boils, blain, ulcers, and gynaecological problems, as well as a blood purifying concoction. The botanical description of the plant, its phytochemical constituents, and its pharmacological activities are discussed, with an emphasis on antibacterial, antihepatotoxic, antifungal, anti-inflammatory, antioxidant, antimicrobial, analgesic, central nervous system depressant, diuretic, oestrogenic, anti-implantation, and anticancer properties. Most pharmacological effects are a result of plant constituents such as alkaloids, terpenoids, tannins, flavonoids, glycosides and phenols, to name a few. Conventional wisdom should be confirmed through in vitro and in vivo studies, as well as clinical trials. Herb's anti-tumor and anti-cancer properties have generated significant interest.
{"title":"PHYTOPHARMACOLOGY OF HOLMSKIOLDIA SANGUINEA RETZ.: A REVIEW","authors":"Rajeev Sati, Monika Bisht","doi":"10.7897/2230-8407.1206144","DOIUrl":"https://doi.org/10.7897/2230-8407.1206144","url":null,"abstract":"Holmskioldia sanguinea Retz. is a Sub-Himalayan plant that has been cultivated in the Americas, Europe, Indo-china, Asia-Pacific, and Southern Africa. It has been used traditionally to treat rheumatism and rheumatoid arthritis, dysentery, headaches, hypertension, boils, blain, ulcers, and gynaecological problems, as well as a blood purifying concoction. The botanical description of the plant, its phytochemical constituents, and its pharmacological activities are discussed, with an emphasis on antibacterial, antihepatotoxic, antifungal, anti-inflammatory, antioxidant, antimicrobial, analgesic, central nervous system depressant, diuretic, oestrogenic, anti-implantation, and anticancer properties. Most pharmacological effects are a result of plant constituents such as alkaloids, terpenoids, tannins, flavonoids, glycosides and phenols, to name a few. Conventional wisdom should be confirmed through in vitro and in vivo studies, as well as clinical trials. Herb's anti-tumor and anti-cancer properties have generated significant interest.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74577294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.7897/2230-8407.1206142
Abdullah, Mounika Pamukuntla
Aim of the study: We aimed to study the efficacy of triple drug therapy which is considered as a standard regimen. Objective of the study: To observe the role of pharmacist in preventing the recurrence of H. pylori infection. To assess whether the drug regimen prescribed eradicates the H. pylori infection. Results: In a period of 6 months a total of 358 cases were observed. Among them 142 cases are rapid urease test +ve and 216 are rapid urease test – ve cases. Of 142 patients included in the analysis, Peptic ulcer disease was more common in men when compared to women and prevalent in age group of 51-60 years. The body mass index analysis showed that 35.2% of patients were obese. From the personal history of the patients, it was concluded that 32.3% were smokers whereas 31.6% were alcoholic. The medication history analysis showed non-steroidal anti-inflammatory drugs were commonly used by the patients. The diagnostic endoscopic reports show that patients suffer from erosive pan gastritis followed by erosive gastritis. Conclusion: A 14-day triple therapy was found to be completely eradicate H. pylori infection. Out of the various demographic details that were taken into consideration age, gender, BMI, smokers, alcoholics, spicy food intake and drug abuse increased symptoms whereas co-morbid illness, sleeping pattern and food interval didn’t affect much. Structured patient counselling and follow up had a significant effect which was seen in the form of zero recurrence, 100% medication adherence and improved quality of life.
{"title":"A PROSPECTIVE, OBSERVATIONAL STUDY ON THE EFFICACY OF DRUG REGIMEN USED FOR HELICOBACTER PYLORI ERADICATION IN PEPTIC ULCER DISEASE","authors":"Abdullah, Mounika Pamukuntla","doi":"10.7897/2230-8407.1206142","DOIUrl":"https://doi.org/10.7897/2230-8407.1206142","url":null,"abstract":"Aim of the study: We aimed to study the efficacy of triple drug therapy which is considered as a standard regimen. Objective of the study: To observe the role of pharmacist in preventing the recurrence of H. pylori infection. To assess whether the drug regimen prescribed eradicates the H. pylori infection. Results: In a period of 6 months a total of 358 cases were observed. Among them 142 cases are rapid urease test +ve and 216 are rapid urease test – ve cases. Of 142 patients included in the analysis, Peptic ulcer disease was more common in men when compared to women and prevalent in age group of 51-60 years. The body mass index analysis showed that 35.2% of patients were obese. From the personal history of the patients, it was concluded that 32.3% were smokers whereas 31.6% were alcoholic. The medication history analysis showed non-steroidal anti-inflammatory drugs were commonly used by the patients. The diagnostic endoscopic reports show that patients suffer from erosive pan gastritis followed by erosive gastritis. Conclusion: A 14-day triple therapy was found to be completely eradicate H. pylori infection. Out of the various demographic details that were taken into consideration age, gender, BMI, smokers, alcoholics, spicy food intake and drug abuse increased symptoms whereas co-morbid illness, sleeping pattern and food interval didn’t affect much. Structured patient counselling and follow up had a significant effect which was seen in the form of zero recurrence, 100% medication adherence and improved quality of life.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82365933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.7897/2230-8407.1206148
V. Vaishnav, D. Sahoo, T. Chatterjee
Medicinal Plants are the good source of natural antimicrobial agents. The main aim of present study was to evaluate the antibacterial activity of stem and root of Rauwolfia serpentina against six microorganism, Powdered stem and root of plant were extracted with acetone, chloroform and methanol and streptomycin used as positive control. The antibacterial activity of Rauwolfia serpentine was detected by using disc diffusion method and agar well diffusion method on the following bacteria- Bacillus cereus, Staphylococcus aureus, Bacillus fusiformis, Escherichia coli, Pseudomonas aeruginosa and P. luminescens. The experiment reported that R. serpentina Root methanol extract shown 14.86 ± 1.11 highest antibacterial activity against Pseudomonas aeruginosa through well diffusion method. Whereas root chloroform recorded 13.46 ± 1.28 highest antibacterial activity against E. coli through disc diffusion method, maximum zone of inhibition 22.66±0.52 mm was found for the positive control, streptomycin through well diffusion method. Further studies should be undertaken to reveal the correct mechanism of action of antimicrobial effect to identify the active ingredients which can be used in drug development program.
{"title":"IN VITRO ASSESSMENT OF ANTIBACTERIAL ACTIVITY OF STEM AND ROOT OF RAUWOLFIA SERPENTINA AGAINST DIFFERENT BACTERIA","authors":"V. Vaishnav, D. Sahoo, T. Chatterjee","doi":"10.7897/2230-8407.1206148","DOIUrl":"https://doi.org/10.7897/2230-8407.1206148","url":null,"abstract":"Medicinal Plants are the good source of natural antimicrobial agents. The main aim of present study was to evaluate the antibacterial activity of stem and root of Rauwolfia serpentina against six microorganism, Powdered stem and root of plant were extracted with acetone, chloroform and methanol and streptomycin used as positive control. The antibacterial activity of Rauwolfia serpentine was detected by using disc diffusion method and agar well diffusion method on the following bacteria- Bacillus cereus, Staphylococcus aureus, Bacillus fusiformis, Escherichia coli, Pseudomonas aeruginosa and P. luminescens. The experiment reported that R. serpentina Root methanol extract shown 14.86 ± 1.11 highest antibacterial activity against Pseudomonas aeruginosa through well diffusion method. Whereas root chloroform recorded 13.46 ± 1.28 highest antibacterial activity against E. coli through disc diffusion method, maximum zone of inhibition 22.66±0.52 mm was found for the positive control, streptomycin through well diffusion method. Further studies should be undertaken to reveal the correct mechanism of action of antimicrobial effect to identify the active ingredients which can be used in drug development program.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78353415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-31DOI: 10.7897/2230-8407.1205136
S KanchanaDevi, G. Rajkumar
The necessary element of non-public protecting instrumentation is mask. Mask is most necessary in pandemic as a result it safeguard our life by stopping the spreading of the Corona virus by entrapping the droplets from the corona affected person to enter wearer’s nose. There are different typed of mask like non- woven mask, reusable mask, N95 mask and artifact mask etc. Majority of business masks are non-woven masks that are created from polypropylene fiber. The most downside of non-woven masks is its discomfort and affect lack of breathability. This drawback is solved by utilizing natural fibers collectively of the material in non-woven and victimization them in mask. Bamboo fiber may be a natural celluloid fiber having smart comfort properties with antimicrobial properties. Bamboo fiber is also hydroscopic, natural deodorizer and hypoallergenic which provides good breathability and comfort. The polypropylene fiber is used with bamboo to provide good strength and abrasion property. Hence an attempt is made to develop a surgical mask from bamboo fiber with different blend ratios of 70:30, 60:40 and 50:50 of Bamboo and Polypropylene fiber to judge its mechanical properties like GSM and thickness potential as a protecting barrier material in non-woven face masks. The developed non-woven fabric of different blend is compared with each other, and the results shows 50: 50 blend has good mechanical properties, and the results show an effective value of Bacterial Filtration efficiency and Differential Pressure which are the most important parameters to predict the filtration efficiency of a surgical mask.
{"title":"DEVELOPMENT OF NON-WOVEN FILTER FOR 3 LAYER MASK FROM BAMBOO/POLYPROPYLENE FIBERS","authors":"S KanchanaDevi, G. Rajkumar","doi":"10.7897/2230-8407.1205136","DOIUrl":"https://doi.org/10.7897/2230-8407.1205136","url":null,"abstract":"The necessary element of non-public protecting instrumentation is mask. Mask is most necessary in pandemic as a result it safeguard our life by stopping the spreading of the Corona virus by entrapping the droplets from the corona affected person to enter wearer’s nose. There are different typed of mask like non- woven mask, reusable mask, N95 mask and artifact mask etc. Majority of business masks are non-woven masks that are created from polypropylene fiber. The most downside of non-woven masks is its discomfort and affect lack of breathability. This drawback is solved by utilizing natural fibers collectively of the material in non-woven and victimization them in mask. Bamboo fiber may be a natural celluloid fiber having smart comfort properties with antimicrobial properties. Bamboo fiber is also hydroscopic, natural deodorizer and hypoallergenic which provides good breathability and comfort. The polypropylene fiber is used with bamboo to provide good strength and abrasion property. Hence an attempt is made to develop a surgical mask from bamboo fiber with different blend ratios of 70:30, 60:40 and 50:50 of Bamboo and Polypropylene fiber to judge its mechanical properties like GSM and thickness potential as a protecting barrier material in non-woven face masks. The developed non-woven fabric of different blend is compared with each other, and the results shows 50: 50 blend has good mechanical properties, and the results show an effective value of Bacterial Filtration efficiency and Differential Pressure which are the most important parameters to predict the filtration efficiency of a surgical mask.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"1 1","pages":"21-24"},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89163114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-31DOI: 10.7897/2230-8407.1205133
M. Kumari, M. Sachdeva, V. Agarwal
This research project is aimed to prepare improved topical preparation of Calcipotriol in the treatment of psoriasis by incorporation of an anti-inflammatory agent, keratolytic agent, humectants, surfactant, thickener & to perform its evaluation. In these different preparations of lotions sodium carboxymethylcellulose is used as a viscosity-enhancing agent in varying concentrations. This non-steroidal formulation is prepared by adding tea tree oil to avoid side effects associated with steroidal preparation and to avoid the issue of atrophy with long-term use of steroids. Evaluation of all the formulations such as spreadability, viscosity, drug content determination, pH, in-vitro release study, to choose the optimized formulation was carried out. According to ICH guidelines, stability studies were carried out to check the stability (parameters such as appearance, pH, viscosity, drug content) of prepared formulations for 3 months at room temperature. In-vitro drug release study CT5 formulation was carried by dialysis diffusion method. The cumulative% drug release of CT5 formulation in 210minutes was 85.10%. Based on the evaluation, formulation (CT5) was found to be better among all the formulations. The prepared calcipotriol formulation and a commercial formulation of calcipotriol were evaluated for anti-psoriatic activity. In-vivo anti-psoriatic was performed by using the Imiquimod Induced Psoriasis skin model. The results obtained in this study have been concluded that the prepared formulation (CT5) has great potential for topical delivery in the treatment of psoriasis.
{"title":"IMPROVED TOPICAL PREPARATION OF CALCIPOTRIOL IN THE TREATMENT OF PSORIASIS","authors":"M. Kumari, M. Sachdeva, V. Agarwal","doi":"10.7897/2230-8407.1205133","DOIUrl":"https://doi.org/10.7897/2230-8407.1205133","url":null,"abstract":"This research project is aimed to prepare improved topical preparation of Calcipotriol in the treatment of psoriasis by incorporation of an anti-inflammatory agent, keratolytic agent, humectants, surfactant, thickener & to perform its evaluation. In these different preparations of lotions sodium carboxymethylcellulose is used as a viscosity-enhancing agent in varying concentrations. This non-steroidal formulation is prepared by adding tea tree oil to avoid side effects associated with steroidal preparation and to avoid the issue of atrophy with long-term use of steroids. Evaluation of all the formulations such as spreadability, viscosity, drug content determination, pH, in-vitro release study, to choose the optimized formulation was carried out. According to ICH guidelines, stability studies were carried out to check the stability (parameters such as appearance, pH, viscosity, drug content) of prepared formulations for 3 months at room temperature. In-vitro drug release study CT5 formulation was carried by dialysis diffusion method. The cumulative% drug release of CT5 formulation in 210minutes was 85.10%. Based on the evaluation, formulation (CT5) was found to be better among all the formulations. The prepared calcipotriol formulation and a commercial formulation of calcipotriol were evaluated for anti-psoriatic activity. In-vivo anti-psoriatic was performed by using the Imiquimod Induced Psoriasis skin model. The results obtained in this study have been concluded that the prepared formulation (CT5) has great potential for topical delivery in the treatment of psoriasis.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72988435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-31DOI: 10.7897/2230-8407.1205135
Namrata S. Mane, Namrata A Muddalwar, Priya V. Nikam, N. Dighade
The aim was to formulate and evaluate fast dissolving tablets of diclofenac sodium to improve the bioavailability of the drug and patient compliance. Fast dissolving tablets of diclofenac sodium were prepared by direct compression method by using superdisintegrants (locust bean gum) in 2%, 3%, 4% 5% & 6% concentration respectively. Tablets were formulated by using natural superdisintegrants locust bean gum (LBG). This formulated mixture i.e., drug and LBG was mixed with other excipients and the tablets were compressed by direct compression. Formulated tablets were characterized by FTIR, pre-compression and post-compression parameters. The In vitro drug release studies were performed in pH 6.8 phosphate buffer. Formulated tablets were characterized by FTIR, the results of IR study showed that there was no interaction between superdisintegrant and pure drug, the results of FTIR study showed that drug was stable in the final formulated tablet. The drug content was evaluated with the help of assay. Five (F1-F5) formulations were evaluated for pre-compression and post-compression parameters and all the results were in the standard limits. Formulated dosage form may be an effective alternative to conventional dosage form which can be effectively used in the treatment of inflammation specially in cases of acute pain.
{"title":"FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET USING LOCUST BEAN GUM AS A NATURAL SUPERDISINTEGRANT AND COMPARISON WITH THE MARKETED PREPARATION","authors":"Namrata S. Mane, Namrata A Muddalwar, Priya V. Nikam, N. Dighade","doi":"10.7897/2230-8407.1205135","DOIUrl":"https://doi.org/10.7897/2230-8407.1205135","url":null,"abstract":"The aim was to formulate and evaluate fast dissolving tablets of diclofenac sodium to improve the bioavailability of the drug and patient compliance. Fast dissolving tablets of diclofenac sodium were prepared by direct compression method by using superdisintegrants (locust bean gum) in 2%, 3%, 4% 5% & 6% concentration respectively. Tablets were formulated by using natural superdisintegrants locust bean gum (LBG). This formulated mixture i.e., drug and LBG was mixed with other excipients and the tablets were compressed by direct compression. Formulated tablets were characterized by FTIR, pre-compression and post-compression parameters. The In vitro drug release studies were performed in pH 6.8 phosphate buffer. Formulated tablets were characterized by FTIR, the results of IR study showed that there was no interaction between superdisintegrant and pure drug, the results of FTIR study showed that drug was stable in the final formulated tablet. The drug content was evaluated with the help of assay. Five (F1-F5) formulations were evaluated for pre-compression and post-compression parameters and all the results were in the standard limits. Formulated dosage form may be an effective alternative to conventional dosage form which can be effectively used in the treatment of inflammation specially in cases of acute pain.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"67 1","pages":"13-20"},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81144009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-31DOI: 10.7897/2230-8407.1205134
Kajal Tomer, D. Gupta
The drug can be released in a controlled manner using a gastro retentive dosage type. The main focus on the novel technological advances in the floating drug delivery method for gastric retention. The preparation of diacerein micro balloon is done by solvent diffusion method, using acrylic polymer like Eudragit S 100 and HPMC K4 M. The various evaluation of the prepared floating microsphere like its % yield, drug entrapment efficiency, particle size in-vitro dissolution, buoyancy, was studied. The floating microsphere was found to be spherical and range from 85 μm - 192 μm. Whereas the buoyancy in gastric mucosa between the range 30.5% -49.5%. The % yield and % entrapment efficiency were found under the range 61% - 82% and 45.1–84.1% respectively. The microsphere showed favorable in-vitro dissolution 76.8 to 94.45. The optimized formulation was found based on evaluation of floating micro-balloons, Formulation (M3E3) showed the best result as particle size 192 μm, DDE 84.1%, in vitro drug release 94.5%, and in vitro buoyancy 49.5%. all the formulations showed controlled release up to 24 hours.
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