The stomach plays an important role in the digestion of the things we consume. This part of the body can withstand a wide range of harmful substances, such as hydrochloric acid, alcohol, refluxed bile salts, and other irritants. Upper abdominal pain may be a symptom of a gastrointestinal disorder known as Peptic Ulcer if you eat an unhealthy diet, smoke, drink too much alcohol, or take NSAIDs on a regular basis. You may also have a sedentary lifestyle. Today, gastric hyperacidity and gastroduodenal ulcers are very common problems all over the world. In this article, the author tries to give an overview of the in vivo and in vitro screening models that have been used in different laboratories and their validation during the past few decades to carry out such investigations, along with the underlying mechanisms of ulcer induction in each approach. The goal is to educate of the various experimental models available for conducting novel investigations to gain further knowledge in context to peptic ulcers.
{"title":"VALIDATION OF SCREENING MODELS OF PEPTIC ULCER: A REVIEW","authors":"Ankita Tripathi, Shubham Srivastava, Minakshi Gupta, Shristi Raj, Farheen Shareef","doi":"10.7897/2230-8407.1212174","DOIUrl":"https://doi.org/10.7897/2230-8407.1212174","url":null,"abstract":"The stomach plays an important role in the digestion of the things we consume. This part of the body can withstand a wide range of harmful substances, such as hydrochloric acid, alcohol, refluxed bile salts, and other irritants. Upper abdominal pain may be a symptom of a gastrointestinal disorder known as Peptic Ulcer if you eat an unhealthy diet, smoke, drink too much alcohol, or take NSAIDs on a regular basis. You may also have a sedentary lifestyle. Today, gastric hyperacidity and gastroduodenal ulcers are very common problems all over the world. In this article, the author tries to give an overview of the in vivo and in vitro screening models that have been used in different laboratories and their validation during the past few decades to carry out such investigations, along with the underlying mechanisms of ulcer induction in each approach. The goal is to educate of the various experimental models available for conducting novel investigations to gain further knowledge in context to peptic ulcers.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74064195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-21DOI: 10.7897/2230-8407.1211170
M. Shende, S. Kadam, M. Mokal, M. P. Balvir
Background: Severe acute malnutrition (SAM), among children below five years of age is global health problem contributing to childhood morbidity, mortality and remains a major embarrassment to optimal human capital development in India. Objectives: Study aim was to accesses fat soluble vitamins deficiencies among children with SAM and outcomes after treatments with F-75/F-100 plus vitamins mix. Methods: The study was prospective observational conducted in the nutritional rehabilitation center (NRC) at district general hospital for 6 months. Anthropometric measurements were taken to determine their nutritional status. Results: 100 patients of NRC were enrolled in the study. Sixty nine percent (69) patients had weight/height (WT/HT) Z score<−3 standard deviation (3 SD), 16 % with Z score<−2 and 15% of them had Z score<−4 malnutrition. Out of 100 children, 46% children were males, and 56% children were females. Vitamin E deficiencies (54%) were highly prevalent in hospitalized SAM groups, followed by 28% vitamin D and 18% were vitamin A deficient. Conclusion: Micronutrient deficiencies were highly prevalent with fat soluble vitamins and recovered on application of WHO protocols during hospitalization induced satisfactory fat-soluble vitamin status recovery significant (p<0.05).
{"title":"PREVALENCE OF FAT-SOLUBLE VITAMIN DEFICIENCIES ASSOCIATED WITH SEVERE ACUTE MALNUTRITION: A PROSPECTIVE OBSERVATIONAL STUDY","authors":"M. Shende, S. Kadam, M. Mokal, M. P. Balvir","doi":"10.7897/2230-8407.1211170","DOIUrl":"https://doi.org/10.7897/2230-8407.1211170","url":null,"abstract":"Background: Severe acute malnutrition (SAM), among children below five years of age is global health problem contributing to childhood morbidity, mortality and remains a major embarrassment to optimal human capital development in India. Objectives: Study aim was to accesses fat soluble vitamins deficiencies among children with SAM and outcomes after treatments with F-75/F-100 plus vitamins mix. Methods: The study was prospective observational conducted in the nutritional rehabilitation center (NRC) at district general hospital for 6 months. Anthropometric measurements were taken to determine their nutritional status. Results: 100 patients of NRC were enrolled in the study. Sixty nine percent (69) patients had weight/height (WT/HT) Z score<−3 standard deviation (3 SD), 16 % with Z score<−2 and 15% of them had Z score<−4 malnutrition. Out of 100 children, 46% children were males, and 56% children were females. Vitamin E deficiencies (54%) were highly prevalent in hospitalized SAM groups, followed by 28% vitamin D and 18% were vitamin A deficient. Conclusion: Micronutrient deficiencies were highly prevalent with fat soluble vitamins and recovered on application of WHO protocols during hospitalization induced satisfactory fat-soluble vitamin status recovery significant (p<0.05).","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90938431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-21DOI: 10.7897/2230-8407.1211171
R. A., T. S
The quality control of herbal medicines has become a major concern to health authorities, health care providers and the manufacturing industries at every stage of production. The standardization of raw drugs and formulations with the help of modern analytical tools increase their scope, acceptance and scientific validity. The safety and efficacy of herbal medicines largely depend on their quality. Neelibhringadi keratailam is an excellent hair growth promoting oil widely prescribed and marketed in Kerala. All the ingredients in the formulation are best hair growth promoters. The knowledge of hair products, their mode of action, efficacy and ingredients has become more relevant today. Neelibhringadi keratailam manufactured by GMP certified Ayurvedic companies in Kerala was assessed by evaluating and comparing the physico chemical parameters of market samples of Neelibhringadi keratailam with that of prepared Neelibhringadi keratailam. Physico chemical parameters such as Acid value (AV), Iodine value (IV), Refractive index (RI) Saponification value (SV), Specific gravity (SG), Weight per milliliter, HPTLC, ICP-MS and microbial contamination of market samples were evaluated and compared with those of prepared sample. Neelibhringadi keram was prepared and its physicochemical analysis was done and compared with market samples. Analysis of the market samples showed significant variation in physicochemical analytical parameters, colour and consistency from the prepared samples.
{"title":"PHYSICO CHEMICAL EVALUATION OF NEELIBHRINGADI KERA TAILAM MANUFACTURED BY AYURVEDIC COMPANIES IN KERALA","authors":"R. A., T. S","doi":"10.7897/2230-8407.1211171","DOIUrl":"https://doi.org/10.7897/2230-8407.1211171","url":null,"abstract":"The quality control of herbal medicines has become a major concern to health authorities, health care providers and the manufacturing industries at every stage of production. The standardization of raw drugs and formulations with the help of modern analytical tools increase their scope, acceptance and scientific validity. The safety and efficacy of herbal medicines largely depend on their quality. Neelibhringadi keratailam is an excellent hair growth promoting oil widely prescribed and marketed in Kerala. All the ingredients in the formulation are best hair growth promoters. The knowledge of hair products, their mode of action, efficacy and ingredients has become more relevant today. Neelibhringadi keratailam manufactured by GMP certified Ayurvedic companies in Kerala was assessed by evaluating and comparing the physico chemical parameters of market samples of Neelibhringadi keratailam with that of prepared Neelibhringadi keratailam. Physico chemical parameters such as Acid value (AV), Iodine value (IV), Refractive index (RI) Saponification value (SV), Specific gravity (SG), Weight per milliliter, HPTLC, ICP-MS and microbial contamination of market samples were evaluated and compared with those of prepared sample. Neelibhringadi keram was prepared and its physicochemical analysis was done and compared with market samples. Analysis of the market samples showed significant variation in physicochemical analytical parameters, colour and consistency from the prepared samples.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77930471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-21DOI: 10.7897/2230-8407.1211169
Chiragkumar J. Gohil, M. Noolvi, C. Patel, D. Sen
Activation of the oncogenes and inhibition of the apoptotic function of the p53 protein is a gateway for the cancer genesis. Interaction of the MDM2 protein with p53 protein is responsible for the inhibition of the p53 function. Inhibiting the p53-MDM2 interaction by drug will lead to the p53 release in the cancer cells. And can restart the apoptosis in the cancer cell. Computational methods successfully used for the design and development of the new, potent MDM2 inhibitors. Researchers and pharma companies used rational approach like target-based drug design or ligand-based drug design to develop the novel MDM2 inhibitors. The number of MDM2 inhibitors, has been designed by the computer-aided drug design and in-silico studies. In clinical studies, MDM2 inhibitors are led by RG7112. RG7112 completed its phase-1 trials in 2016, and recently it is under phase-2 trials. Along with RG7112, the number of potent MDM2 inhibitors entered the clinical trials successfully. It indicates the successful development of this class (MDM2 inhibitors). MDM2 inhibitors were found very effective in various studies for the treatment of various kinds of cancers. They have good selectivity for the tumor cells over the normal cells. It induced the dose dependent cell cycle arrest only; in the normal cells. In studies, MDM2 inhibitors successfully detached the p53 protein from the MDM2 protein. And restart the cell-killing function of the p53 protein in the cancer cells. Hence, MDM2 inhibitors can selectively kill the cancer cells over the normal cells.
{"title":"REVIEW OF DESIGN APPROACHES AND CLINICAL PROGRESS OF MDM2 INHIBITORS","authors":"Chiragkumar J. Gohil, M. Noolvi, C. Patel, D. Sen","doi":"10.7897/2230-8407.1211169","DOIUrl":"https://doi.org/10.7897/2230-8407.1211169","url":null,"abstract":"Activation of the oncogenes and inhibition of the apoptotic function of the p53 protein is a gateway for the cancer genesis. Interaction of the MDM2 protein with p53 protein is responsible for the inhibition of the p53 function. Inhibiting the p53-MDM2 interaction by drug will lead to the p53 release in the cancer cells. And can restart the apoptosis in the cancer cell. Computational methods successfully used for the design and development of the new, potent MDM2 inhibitors. Researchers and pharma companies used rational approach like target-based drug design or ligand-based drug design to develop the novel MDM2 inhibitors. The number of MDM2 inhibitors, has been designed by the computer-aided drug design and in-silico studies. In clinical studies, MDM2 inhibitors are led by RG7112. RG7112 completed its phase-1 trials in 2016, and recently it is under phase-2 trials. Along with RG7112, the number of potent MDM2 inhibitors entered the clinical trials successfully. It indicates the successful development of this class (MDM2 inhibitors). MDM2 inhibitors were found very effective in various studies for the treatment of various kinds of cancers. They have good selectivity for the tumor cells over the normal cells. It induced the dose dependent cell cycle arrest only; in the normal cells. In studies, MDM2 inhibitors successfully detached the p53 protein from the MDM2 protein. And restart the cell-killing function of the p53 protein in the cancer cells. Hence, MDM2 inhibitors can selectively kill the cancer cells over the normal cells.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80849433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-14DOI: 10.7897/2230-8407.1210166
V. Manikandan, K. Kathiresan
Technology transfer plays a milestone in the pharmaceutical industry during the citation of drug discovery to drug product development. Technology transfer technique transferred from Research & Development (R&D) department to production department through the process of the research phase, development phase, and production phase for further product commercialization. This study was an attempt to discuss the reasons and importance of technology transfer, processing steps for technology transfer, and its documentation report. Establishing confirmation technique for all kinds of documentation and will be inspected and accepted by quality assurance department before the technologies reaches the production department. Hence, the proposed transferring technique will help to develop the product through the processes mentioned in the documentation report.
{"title":"TECHNOLOGY TRANSFER FROM R & D TO PRODUCTION AND ITS DOCUMENTATION IN PHARMACEUTICAL INDUSTRY: A REVIEW","authors":"V. Manikandan, K. Kathiresan","doi":"10.7897/2230-8407.1210166","DOIUrl":"https://doi.org/10.7897/2230-8407.1210166","url":null,"abstract":"Technology transfer plays a milestone in the pharmaceutical industry during the citation of drug discovery to drug product development. Technology transfer technique transferred from Research & Development (R&D) department to production department through the process of the research phase, development phase, and production phase for further product commercialization. This study was an attempt to discuss the reasons and importance of technology transfer, processing steps for technology transfer, and its documentation report. Establishing confirmation technique for all kinds of documentation and will be inspected and accepted by quality assurance department before the technologies reaches the production department. Hence, the proposed transferring technique will help to develop the product through the processes mentioned in the documentation report.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80764741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-14DOI: 10.7897/2230-8407.1210167
Anjaly Pr, Madhushree Hs, Ganesh Puttur
The Shodhana procedures are mainly divided into three phases known as Trividha Karma. Acharya Dalhana has clarified Trividha Karma in the context of Shodhana as Poorva Karma, Pradhana Karma and Paschat Karma. Samsarjana Krama is a special diet pattern which is followed as Paschat Karma after Samshodhana. After Samshodhana Karma the Atura Shareera will have reduced tolerance owing to the elimination of large quantities of Dosha and Mala from the body, leading to weakness and reduction in digestive fire. This can be corrected only by following proper Samsarjana Krama with respect to the Shuddhi attained by the Atura. Acharyas detailed the Samsarjana Krama for two Annakala with respect to the ancient time period in contrast to the present scenario, where we are following three Annakala. To get a successful result from the treatment the patient should follow all the 3 stages properly. Hence, here an attempt is made to modify the Samsarjana Krama chart for the present era with respect to classical information given by the Acharyas.
{"title":"PRACTICAL UTILITY OF SAMSARJANA KRAMA: A REVIEW","authors":"Anjaly Pr, Madhushree Hs, Ganesh Puttur","doi":"10.7897/2230-8407.1210167","DOIUrl":"https://doi.org/10.7897/2230-8407.1210167","url":null,"abstract":"The Shodhana procedures are mainly divided into three phases known as Trividha Karma. Acharya Dalhana has clarified Trividha Karma in the context of Shodhana as Poorva Karma, Pradhana Karma and Paschat Karma. Samsarjana Krama is a special diet pattern which is followed as Paschat Karma after Samshodhana. After Samshodhana Karma the Atura Shareera will have reduced tolerance owing to the elimination of large quantities of Dosha and Mala from the body, leading to weakness and reduction in digestive fire. This can be corrected only by following proper Samsarjana Krama with respect to the Shuddhi attained by the Atura. Acharyas detailed the Samsarjana Krama for two Annakala with respect to the ancient time period in contrast to the present scenario, where we are following three Annakala. To get a successful result from the treatment the patient should follow all the 3 stages properly. Hence, here an attempt is made to modify the Samsarjana Krama chart for the present era with respect to classical information given by the Acharyas.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74392217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-14DOI: 10.7897/2230-8407.1210168
M. Mohankumar, G. Sivakamasundari
Validation is a notable step in fulfilling and keep the character of the last decision. In the event that every progress of the creative process is recognized, we can guarantee that the end result will be of the best quality. Validation is specialized for planning and rehearsing a closely planned step with documents. Verification and quality assurance are inseparable, which guarantees careful quality of products. The process validation underscores the components of the measurement scheme and adheres to the measurement control during commercialization and realizes that it is nothing more than a continuous program and adjust the measurement validation exercises with the item life cycle. The motivation behind this survey is to introduce a presentation and general disclosure on quantitative validation of pharmaceutical production with a unique note to the requirements specified by the US Food and Drug Administration (FDA).
{"title":"A REVIEW ON PHARMACEUTICAL VALIDATION AND ITS IMPORTANCE AND IMPUTATION","authors":"M. Mohankumar, G. Sivakamasundari","doi":"10.7897/2230-8407.1210168","DOIUrl":"https://doi.org/10.7897/2230-8407.1210168","url":null,"abstract":"Validation is a notable step in fulfilling and keep the character of the last decision. In the event that every progress of the creative process is recognized, we can guarantee that the end result will be of the best quality. Validation is specialized for planning and rehearsing a closely planned step with documents. Verification and quality assurance are inseparable, which guarantees careful quality of products. The process validation underscores the components of the measurement scheme and adheres to the measurement control during commercialization and realizes that it is nothing more than a continuous program and adjust the measurement validation exercises with the item life cycle. The motivation behind this survey is to introduce a presentation and general disclosure on quantitative validation of pharmaceutical production with a unique note to the requirements specified by the US Food and Drug Administration (FDA).","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80305979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-14DOI: 10.7897/2230-8407.1210165
Arpana Maurya, D. Gupta, Munendra Mohan Varshaney
Orodispersible tablets (ODTs) are novel drug delivery systems that have the potential to significantly affect conventional dosage forms in terms of patient compliance, convenience, bioavailability, and time to action. Despite the fact that significant research has gone into developing ODT formulations and technologies, in order to produce newer, more expense technologies and better items, more research is needed in these major destinations. Because of the availability of new technologies, as well as good market acceptance and patient compliance, the potential of dosage forms is attractive. Pharmaceutical companies can use ODTs for new product lines or first-to-market products, which is a factor in technology. With the continuing development of new pharmaceutical excipients, more unique ODT technologies are likely to occur soon. Method -For the orodispersible tablet optimized formulation, a direct compression method was used. Result: The pure dosage calibration curve was created by dissolving the medication in ethanol and measuring the absorbance with a UV spectrophotometer set at 243.5 nm. The value of the slope was 1.025. Light microscopy was used to predict the size of teneligliptin particles. The average length and breadth of drug particles were 2.10 µm and 1.14µm. In-vitro drug release study profile of formulation demonstrated around 71 % of the drug diffused in 60 min., while the formulation 85 % of the rug release in 60 min.
{"title":"FORMULATE AND EVALUATE THE ORAL DISPERSIBLE TABLET OF ANTIDIABETIC DRUG TENELIGLIPTIN","authors":"Arpana Maurya, D. Gupta, Munendra Mohan Varshaney","doi":"10.7897/2230-8407.1210165","DOIUrl":"https://doi.org/10.7897/2230-8407.1210165","url":null,"abstract":"Orodispersible tablets (ODTs) are novel drug delivery systems that have the potential to significantly affect conventional dosage forms in terms of patient compliance, convenience, bioavailability, and time to action. Despite the fact that significant research has gone into developing ODT formulations and technologies, in order to produce newer, more expense technologies and better items, more research is needed in these major destinations. Because of the availability of new technologies, as well as good market acceptance and patient compliance, the potential of dosage forms is attractive. Pharmaceutical companies can use ODTs for new product lines or first-to-market products, which is a factor in technology. With the continuing development of new pharmaceutical excipients, more unique ODT technologies are likely to occur soon. Method -For the orodispersible tablet optimized formulation, a direct compression method was used. Result: The pure dosage calibration curve was created by dissolving the medication in ethanol and measuring the absorbance with a UV spectrophotometer set at 243.5 nm. The value of the slope was 1.025. Light microscopy was used to predict the size of teneligliptin particles. The average length and breadth of drug particles were 2.10 µm and 1.14µm. In-vitro drug release study profile of formulation demonstrated around 71 % of the drug diffused in 60 min., while the formulation 85 % of the rug release in 60 min.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79572330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-14DOI: 10.7897/2230-8407.1210164
Deeya Baboo, Prajwal Narayan, Ganesh Puttur
Ayurveda (Science of life) has explained about the pathogenesis and the treatment of various disorders, the incidence of some of which have increased in the present scenario due to altered diet habits and lifestyle. Janu Sandhigata Vata is one among the Vata Vyadhi which causes a lot of inconvenience and disability in day-to-day activities. It is compared to Osteoarthritis of knee in modern Science. In this case study, a female aged about 57 years presented in the OPD of SSCASRH, Bengaluru was diagnosed with Janu Sandhigata Vata of both the knee joints. Arohana Krama Matra Basti with Prasarini taila was planned as per Sharangadhara’s reference. There was significant improvement in the patient and was evaluated after treatment and also during follow up. There was marked relief with respect to her subjective complaints like pain, improved joint space, walking time, degree of flexion and extension & X ray. This type of Arohana Krama Matra Basti can be adopted in future for planning treatment in Janu Sandhigata Vata and also taken up in a larger group study to check for better relief, long term effect and reduced side effects. The case is further elaborated in the article
{"title":"AROHANA KRAMA MATRA BASTI IN JANU SANDHIGATA VATA: A CASE STUDY","authors":"Deeya Baboo, Prajwal Narayan, Ganesh Puttur","doi":"10.7897/2230-8407.1210164","DOIUrl":"https://doi.org/10.7897/2230-8407.1210164","url":null,"abstract":"Ayurveda (Science of life) has explained about the pathogenesis and the treatment of various disorders, the incidence of some of which have increased in the present scenario due to altered diet habits and lifestyle. Janu Sandhigata Vata is one among the Vata Vyadhi which causes a lot of inconvenience and disability in day-to-day activities. It is compared to Osteoarthritis of knee in modern Science. In this case study, a female aged about 57 years presented in the OPD of SSCASRH, Bengaluru was diagnosed with Janu Sandhigata Vata of both the knee joints. Arohana Krama Matra Basti with Prasarini taila was planned as per Sharangadhara’s reference. There was significant improvement in the patient and was evaluated after treatment and also during follow up. There was marked relief with respect to her subjective complaints like pain, improved joint space, walking time, degree of flexion and extension & X ray. This type of Arohana Krama Matra Basti can be adopted in future for planning treatment in Janu Sandhigata Vata and also taken up in a larger group study to check for better relief, long term effect and reduced side effects. The case is further elaborated in the article","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"394 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72611511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-11DOI: 10.7897/2230-8407.1209162
S. Bhavin, G. Anuradha
The application of the ratio spectra derivative spectrophotometry to the simultaneous determination of Paracetamol (PCM) and Tapentadol (TAP) in combined pharmaceutical tablets is presented. The spectrophotometric procedure is based on the use of the first derivative of the ratio spectra obtained by dividing the absorption spectrum of the binary mixtures by a standard spectrum of one of the compounds. The first derivative amplitudes were measured at 220 and 232 nm for the assay of TAP and PCM, respectively. Calibration graphs were established for 1-5 μg mL-1 for TAP and 6.5-32.5 μg mL-1 for PCM in binary mixture. The detection limits for TAP and PCM were found 0.098 and 0.595 μg mL-1, respectively, while the quantification limits were 0.298 μg mL-1 for TAP and 1.805 μg/ml for PCM. The relative standard deviations were found to be less than 2%, indicating reasonable repeatability of both methods. The proposed methods were hence validated as per ICH guidelines and successfully applied to the determination of these drugs in commercial tablets.
{"title":"SIMULTANEOUS DETERMINATION OF PARACETAMOL AND TAPENTADOL IN TABLETS BY RATIO SPECTRA DERIVATIVE SPECTROPHOTOMETRY","authors":"S. Bhavin, G. Anuradha","doi":"10.7897/2230-8407.1209162","DOIUrl":"https://doi.org/10.7897/2230-8407.1209162","url":null,"abstract":"The application of the ratio spectra derivative spectrophotometry to the simultaneous determination of Paracetamol (PCM) and Tapentadol (TAP) in combined pharmaceutical tablets is presented. The spectrophotometric procedure is based on the use of the first derivative of the ratio spectra obtained by dividing the absorption spectrum of the binary mixtures by a standard spectrum of one of the compounds. The first derivative amplitudes were measured at 220 and 232 nm for the assay of TAP and PCM, respectively. Calibration graphs were established for 1-5 μg mL-1 for TAP and 6.5-32.5 μg mL-1 for PCM in binary mixture. The detection limits for TAP and PCM were found 0.098 and 0.595 μg mL-1, respectively, while the quantification limits were 0.298 μg mL-1 for TAP and 1.805 μg/ml for PCM. The relative standard deviations were found to be less than 2%, indicating reasonable repeatability of both methods. The proposed methods were hence validated as per ICH guidelines and successfully applied to the determination of these drugs in commercial tablets.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77732284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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