International Journal of Trichology最新文献

Background: Androgenetic alopecia (AGA) is a disease of polygenic etiology. Androgens play a vital role in the development of patterned hair loss. Dutasteride is an anti-androgen that acts by competitively inhibiting both type 1 and type 2 isoenzymes of 5α reductase. The intradermal deposition of dutasteride has the advantage of negligible systemic absorption. Although dutasteride mesotherapy has not been approved by the Food and Drug Administration, it has been used off-label in the treatment of AGA. Here, we report 4 case series of nonscarring alopecia that developed following a single session of mesotherapy injection.

Materials and methods: A total of 15 cases with patterned hair loss were enrolled (13 males and 2 females). The grade of patterned hair loss was between Norwood Hamilton grade 3-6, and in Ludwig pattern between 2 and 3. Once a month intradermal injection of dutasteride mesotherapy was administered in all cases. To standardize the drug administration and for uniform delivery of the drug, 1 cm² grids were created and 2 units at each point was administered at an angle of 60°, a total of 2 ml of 0.01% of dutasteride was administered in each session.

Results: Mean age of 31.53. The most common adverse effect noted was noncicatricial alopecia was noted in four cases, (3 males and 1 female), followed by pain, itching 1 case each, respectively. The grade of alopecia was AGA grade 5-6, 1 male with Ludwig grade 2 pattern of hair loss and a female with Ludwig grade 2. They developed patchy alopecia involving the mesotherapy site following a single session of dutasteride mesotherapy.

Conclusion: There is a need for stringent monitoring of manufacturing guidelines of mesotherapeutic cocktails by governing bodies. It should primarily address the optimal concertation of the active ingredients and preservative usage to avoid untoward side effects. The benzyl alcohol and polysiloxane in the cocktail could be the key players having cytotoxic effects, contributing to the development of alopecia. The knowledge of potential adverse effects caused by a drug should always be in the mind of the treating physician.

Artificial intelligence (AI) is intelligence exhibited by computation, as opposed to natural human intelligence. Founded as an academic discipline in 1956, AI went through cycles of optimism, followed by periods of disappointment. The growing use of AI in our century is influencing a shift toward increased automation, data-driven decision-making, and the integration of AI systems into various areas of life, including health care. On the occasion of the European Academy of Dermatology and Venereology Spring Symposium 2024, reference was made to AI in dermatology, specifically trichology. Particularly in the domain of trichoscopy, AI's contribution to automated image analysis stands out. Due to the fairly standardized imaging and a limited amount of diagnoses, trichoscopic images have become a center of interest for automated medical image analysis and its commercial utilization. Yet, costly, multi-parameter computer-assisted trichoscopic image analysis is the least effective in medical practice. Using dermoscopy, signature patterns are seen in a range of scalp and hair conditions that have provided the foundation for diagnostic algorithms. Algorithms discourage physicians from thinking independently and with creativity. Doctors are trained to romance with technology. However, healing is replaced with treating, caring is supplanted by managing, and the art of listening is taken over by technology. The power of technology, particularly computer-based, may shake the confidence of a specialist in his initial diagnosis. Nevertheless, machines cannot replace the doctor's mind, and his thinking about what he sees and what he does not see. Ultimately, common AI mistakes are often not too different from mistakes born out of natural human error. Taking all of this into account, it does not seem wise to precociously hail an evolving technology in public without the respective experimentation and experience to back up its factual utility in our practice.

A Saint is a person who is recognized as having an exceptional degree of Holiness, likeness, or closeness to the Godhead. Many religions use similar concepts, albeit different terminologies, to venerate persons worthy of some honor. Saints across various cultures and religions have the following family resemblances: exemplary model, extraordinary teacher, wonder worker or source of benevolent power, intercessor, life often refusing material attachments or comforts, and possession of a special and revelatory relation to the Holy. From the beginning of civilization, man has placed importance on the appearance and symbolism of hair. Peculiarities relating to the hair of Saints are the miracle of hair growth (St. Agnes of Rome), long and beautiful hair (St. Mary Magdalene), long and disheveled hair (St. Mary of Egypt), generalized hypertrichosis (St. Onuphrius), facial hirsutism (St. Wilgefortis), and overnight whitening of hair (St. Thomas More). Therefore, the Saints whose attributes relate to the hair have proven suitable candidates for a number of varied trichological issues. Finally, in challenging times with capitalist technocracy changing the face of our practice at the cost of our spirituality, it is wise to get back to the basics and reflect on the examples of the Saints. Saint Josemaría Escrivá taught that everyone is called to Holiness and to discover Sanctity in their ordinary lives. The role of the Saints is to act as spiritual guides, mentors, and examples of faith. In many religions, there are individuals who have been recognized within their tradition as having fulfilled the highest aspirations of religious teaching. In English, the term Saint is often used to translate this idea from many world religions, which proves the universality of Sainthood.

Trichoteiromania is a self-inflicted compulsive hair disease present with an uncontrollable desire to rub leading to subsequent damage to the hair shaft. We report a case series of five cases of trichoteiromania that were diagnosed with trichoscopic assistance. Trichoscopy revealed broken hairs, longitudinal splits along the whole length of hair representing broom-like hairs, background erythema, and white scales. Trichoteiromania is a rare self-inflicting obsessive-compulsive disease that needs to be differentiated from other types of self-inflicting hair disorders. Broom hair was the most common trichoscopic finding. A combined pharmacopsychotherapy results in a very good clinical response.

Hair is one of the most commonly encountered trace evidence of crime scenes. The cases in which it may be found as evidence vary, ranging from those involving exotic and endangered wildlife species, hunting of which has been prohibited to various homicidal and assault cases. Besides homicide, sexual assault, and rape cases, hair is common evidence in poaching and other wildlife-related cases. The forensic examination of hair can help in personal identification (from human hair) and species identification (from nonhuman hair). Conventionally, the hair examination starts with the microscopic examination which is further extended to modern analytical methods such as DNA profiling, neutron activation analysis, inductively coupled plasma-mass spectrometry, scanning electron microscopy-electron-dispersive X-ray spectroscopy, infrared spectroscopy. However, recent years have observed significant improvement in the sensitivity, reliability, and applicability of these methods. In the present review, a critical analysis of methods of hair examination has been done.

Effective trichological practice is not a closed art, to be mastered only after years of perfecting and struggling with the mysteries of hair growth and shedding, and the trichological consultation is not one that takes longer than any other dermatological issue, nor is the trichological patient more difficult to manage. Although everyone may want to do their job the right way, everyone's version of that right thing may vary. A standard operating procedure (SOP) is a set of step-by-step instructions compiled to help carry out routine operations. SOPs aim to achieve efficiency, quality output, and uniformity of performance while reducing miscommunication and failure to comply with regulations. Working in alignment with SOPs is an essential aspect of any organization, especially in healthcare. As with any medical problem, the patient complaining of hair loss requires a comprehensive medical and drug history, physical examination of the hair and scalp, and appropriate laboratory evaluation to identify the cause. Once a diagnosis is certain, appropriate treatment is likely to control hair loss. However, treatment success relies on patient compliance that, on its part, relies on confidence and motivation. For this purpose, regular follow-up visits at 3, 6, and 12 months with global photographic assessments in tandem with epiluminiscence microscopic photography are recommended. The overall goal is to gain short-term compliance as a prerequisite to long-term adherence to treatment. Under these conditions, patients' adherence to follow-up is over 90%.

Background: Hair follicles undergo growth, regression, and quiescence. It is suspected that adipocytes secrete factors that promote the activation of follicular dermal papilla cells, increase migration and proliferation in vitro, and increase the conversion of hair follicles from the telogen to anagen phase in vivo.

Objectives: To evaluate the efficacy of adipose derived stem cells (ADSCs) injection for the treatment of female pattern hair loss (FPHL).

Patients and methods: This prospective randomized controlled trial included 33 patients divided into three groups according to Sinclair classification. ADSCs were extracted from autologous fat obtained from the lipoaspirate, cultured, and injected into the frontoparietal scalp. The patients were assessed clinically, trichoscopically, histopathologically, and immunohistochemically for hair cycle markers.

Results: At weeks 12 and 24, there was an improvement in hair thickness and count, and an increased number of hairs per follicular unit. Histopathological and immunohistochemical assessments at week 12 showed a decrease in perifollicular inflammation, an increase in the hair cycle stimulatory marker (follistatin), and a decrease in hair cycle suppressor (DKK-1) immunostaining.

Conclusion: The use of ADSCs in subjects with FPHL included in this study showed increased hair density and thickness, improved perifollicular inflammation, and enhanced hair cycle regeneration markers.