International Journal of Trichology最新文献

Aplasia cutis congenita (ACC) is a rare congenital disorder characterized by the absence at birth, of skin, dermal appendages, and, in some cases, subcutaneous tissues. The scalp is the most commonly affected area. Usually, particularly after conservative or minimally invasive management at birth, it results in an area of alopecia. We describe a case of post-ACC alopecia of the scalp treated with follicular unit transplantation, combined with platelet-rich plasma and fat grafting. In our patient, this combined therapeutic strategy induced radical modifications of hair follicles, skin quality, and also sensitivity of the affected area.

Woke is an adjective meaning "alert to racial prejudice and discrimination." Originally referring to an awareness of social and political issues affecting African Americans, over time, it became increasingly connected to matters beyond race, such as gender and identities perceived as marginalized, and eventually appropriated by white people to encompass a broader awareness of social inequalities beyond racial injustice, such as sexism, and denial of lesbian, gay, bisexual trans, queer, intersex (LGBTQI) rights. As its use spread internationally, woke was added to the Oxford English Dictionary in 2017. Woke has also been used as shorthand for some ideas of the American Left involving identity politics and social justice. By 2020, the political right began using the term sarcastically as a pejorative for various leftist and progressive movements and ideologies, implying that wokeness was an insincere form of performative activism. The issue of wokeness in medical practice has as yet not found the due attention both in terms of discrimination in employment or in medical care. While the former lies in the personal responsibility of the employer as an individual or an institution, the latter lies in the accountability of our profession as a group. Nevertheless, dermatology has always shown a particular interest in ethnic skin and hair and is taking gender-affirming cosmetic dermatology at heart. Dermatologists are aware of dermatologic conditions with a particular predilection for the black population in terms of frequency and severity due to peculiarities of hair anatomy and hair grooming habits. Furthermore, there are ethnic considerations in hair restoration surgery essential for hair transplant surgeons to understand so that esthetic results can be achieved. Dermatologists are experts in many of the medical treatments and minimally invasive procedures gender-diverse individuals seek. Such procedures include laser hair reduction, neurotoxins, soft-tissue augmentation, body sculpting and contouring, and alopecia management.

Fibrosing alopecia in a pattern distribution (FAPD) is a cicatricial alopecia characterized by an androgenetic alopecia (AGA)-like pattern hair loss (PHL) associated with a lichen planopilaris (LPP)-like infiltrate on histopathology. Prepubertal PHL is the term proposed for AGA in children. The pattern is exclusively that of female PHL. We report the first case of FAPD in a child with prepubertal PHL. A 9-year-old girl initially presented with chronic itching, redness, and scaling of the central scalp area, which eventually developed to a cicatricial PHL with histopathological evidence of LPP. The implication of a follicular microinflammation and fibrosis associated with AGA has emerged from several studies. Ultimately, Zinkernagel and Trüeb reported a peculiar cicatricial PHL with histopathological features of LPP and named it FAPD. So far, FAPD has only been observed in adults. The observation of FAPD in a child with prepubertal PHL suggests that the condition is not androgen dependent and may explain the limited efficacy of 5-alpha reductase inhibitors for treatment of FAPD. The primary aims for treatment are anti-inflammatory in combination with a hair growth-promoting agent such as minoxidil.

Background: Frontal fibrosing alopecia (FFA) is a scarring alopecia with a complex pathogenesis that is not completely clear yet.

Objective: The aims of the study were to evaluate serum peroxisome proliferator-activated receptor gamma (PPARγ) levels and gene polymorphism in a sample of Egyptian FFA patients.

Subjects and methods: The case-control study included 93 FFA female patients and 157 matching apparently healthy control subjects. Patients were subjected to clinical and trichoscopic examinations to diagnose FFA according to the updated diagnostic criteria. FFA severity was evaluated using the FFA Severity Index (FFASI). Serum PPARγ levels and gene polymorphisms were assessed in all participants using enzyme-linked immunosorbent assay and polymerase chain reaction techniques, respectively.

Results: Serum PPARγ levels in the patients' group were significantly lower than that of the control subjects' group. PPARG (Pro12Ala) gene polymorphism was significantly predominant in FFA patients when compared to the control subjects. Patients carrying polymorphic genotypes showed significantly reduced serum PPARγ levels when compared to patients carrying the wild genotype. They also showed significantly higher FFASI in comparison to wild genotype carriers.

Conclusion: PPARγ may play an important role in FFA development. It might have a potential utility as a biomarker in FFA.

Nataraja is a well-known sculptural symbol in India and popularly used as a symbol of Indian culture. It is a depiction of Lord Shiva as the cosmic dancer who performs his divine dance as creator, preserver, and destroyer of the universe and conveys the Indian conception of the never-ending cycle of time. The same principle manifests in the hair cycle. Nataraja's right foot is planted squarely on the demon Apasmara. A dwarf, immensely powerful in his malignity, Apasmara is the embodiment of ignorance, and the manifestation of greedy, possessive selfhood. We have recently drawn attention to a practice of dishonesty in academic medicine, the deliberate act of ignoring the scientific work of others where it would be appropriate to acknowledge. Unless due to poor literacy or intellectual failure, this is usually deliberately practiced in an atmosphere of hostility or coterie, especially one that is exclusive of peers. Eponyms have a historical tradition in Western medical terminology. At a time when medicine did not command the means to investigate underlying causes, the eponym was a convenient way to label a disease condition. Conventionally, diseases have been named after the individual who originally described the condition. Being awarded an eponym has always been regarded as an honor, while the scientific community considers it as bad form to attempt to eponymize oneself. In an age, in which the person cult of the distinguished personalities of the past has become obsolete, the social media have created a new cult of the self. This cult has within it traits of narcissism: superficial charm, grandiosity and self-importance, a penchant for deception, and manipulation, and incapacity for remorse or guilt. In this atmosphere lure, the risks in the creation of personal eponyms: history sometimes shows credit should have gone to a different person. The possessive use of an eponym should be discontinued, since the author neither had nor owned the disorder. Finally, eponyms with derogative connotations should be omitted. There is a need to refrain from using inappropriate and controversial eponyms. Further academic and scientific efforts should be addressed to provide a structural systematization, semantic classification, and etymological categorization in medical nomenclature.

The introduction of three-dimensional (3D) printing technology has transformed several disciplines, including therapeutic approaches, by offering novel alternatives for hair regrowth and scalp therapy. This brief overview looks at 3D printing's existing applications in neurology, with a focus on its ability to manufacture personalized hair follicles, prostheses, and surgical templates that will improve the efficiency of hair restoration surgeries. It investigates the materials used in 3D printing, including as biocompatible polymers and bioinks, which enable the creation of patient-specific solutions. Furthermore, this study emphasizes the constraints and limitations of incorporating 3D printing into clinical practice, such as regulatory issues and the need for additional research to investigate long-term effects. This study seeks to provide insights into the transformative impact of 3D printing in enhancing trigeminal therapeutics and improving patient outcomes by combining existing literature.

Aim: The purpose of this in vitro hair graft study was to better understand how different storage media affect the survival of hair follicles at different temperatures during a hair transplant procedure.

Materials and methods: In this study, hair follicles (n = 60) were harvested from 3 healthy male volunteers. Follicles were randomly assigned to the following groups: Group A: Storage media phosphate-buffered saline (PBS), platelet-rich plasma (PRP), platelet-rich fibrin (I-PRF), and Dulbecco's Modified Eagle Medium (DMEM). Group B: Storage media were placed at the following temperatures: 4°C, 26°C (room temperature), and 37°C (body temperature). The viability of hair follicles was checked using the explant culture method. Cell outgrowth was observed after incubation at 37°C in DMEM containing 10% FBS.

Results: Explant cultures of hair follicles stored at 4°C and 26°C did not show outgrowth of the cells after 7 days of culture. Explant cultures of hair follicles stored at 37°C did show outgrowth of the cells after 7 days of culture. Furthermore, these study results indicated that 10% DMEM preserves hair follicles more effectively than PBS, PRP, and I-PRF.

Conclusion: According to the study's findings, freezing graft storage options might not be the best option. Instead of 4°C or room temperature 26°C, 37°C has been shown to improve hair graft survival. Furthermore, these study results indicated that 10% DMEM preserves hair follicles more effectively than PBS, PRP, and I-PRF. The study concluded that maintaining hair follicles in 10% DMEM at 37°C would prolong graft life and improve therapeutic outcomes.