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A Rare Case of Localized Hypertrichosis in Conjunction with Erythema Nodosum. 一例罕见的伴结节性红斑的局部性多毛症。
Q2 Medicine Pub Date : 2023-03-01 Epub Date: 2023-07-28 DOI: 10.4103/ijt.ijt_167_20
Yeon Seok Lee, June Hyunkyung Lee, Tae Young Han, Jae Eun Choi

Acquired hypertrichosis can occur in local inflammation. Erythema nodosum (EN) is a hypersensitivity reaction to various underlying antigenic stimuli including Mycobacterium tuberculosis, which causes inflammation in the septa of subcutaneous fat. There were several case reports that describe the association of localized hypertrichosis (LH) with traumatic panniculitis and lupus panniculitis. To our knowledge, this is the first reported case of acquired LH associated with EN. Thus, EN can be added to the list of causes of localized hypertrichosis.

获得性多毛症可发生在局部炎症中。结节性红斑(EN)是一种对各种潜在抗原刺激的超敏反应,包括结核分枝杆菌,它会引起皮下脂肪间隔的炎症。有几个病例报告描述了局限性多毛症(LH)与创伤性脂膜炎和狼疮性脂膜炎的相关性。据我们所知,这是第一例与EN相关的获得性LH病例。因此,EN可以被添加到局部多毛症的病因列表中。
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引用次数: 0
Cemiplimab-Induced Alopecia Areata. Cemiplimab诱发斑秃。
Q2 Medicine Pub Date : 2023-03-01 Epub Date: 2023-07-28 DOI: 10.4103/ijt.ijt_107_21
Bianca Maria Piraccini, Francesca Comito, Barbara Melotti, Ignazio Stanganelli, Metelda Medri, Francesco Savoia
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引用次数: 0
A Study of Correlation of Alopecia Areata and Metabolic Syndrome in Northwest Indian Population: A Case-Control Study. 印度西北地区人群斑秃与代谢综合征相关性研究:病例对照研究。
Q2 Medicine Pub Date : 2023-03-01 Epub Date: 2023-07-28 DOI: 10.4103/ijt.ijt_89_21
Heena Singdia, Puneet Bhargava, Shivi Nijhawan, Deepak Kumar Mathur

Context: Alopecia areata (AA) is the most common cause of inflammatory, nonscarring hair loss, involving hair-bearing areas of the body. The etiology of AA still remains uncertain; however, genetic, environmental, and autoimmunity play a role. Newer theories such as oxidative theory, HPA axis activation, and finally, the role of increased inflammatory cytokines such as interleukin 1 (IL1), tumor necrosis factor-alpha, interferon-gamma, IL-2 IL-4, and MIF are suggested to contribute to both AA and metabolic syndrome (MS).

Aims: Assessment of the degree of association of MS (NCEP ATP III criteria) in clinically diagnosed cases of AA and compare to that of controls.

Materials and methods: Similar age/sex-matched AA patients and controls (106 in each group) were taken. Anthropometric measurements, blood-sugar estimation, lipid-profile estimation in venous blood sample, and blood-pressure measurement were done.

Results: Prevalence of MS was almost similar among cases of AA 9/106 (8.47%) as well as healthy controls 8/106 (7.54%), and the difference was not statistically significant (P = 1). Among all components of MS, waist circumference (WC) (central obesity) was the most common parameter (100% cases). In controls, high systolic blood pressure (SBP) was the most common parameter (77.78% controls). AA is associated with a higher level of SBP, diastolic blood pressure (DBP), WC although nonsignificant, and low level of high-density lipoprotein cholesterol which was the only significant association.

Conclusion: Insignificant correlation between occurrence of MS and evidence of insulin resistance (IR) in AA was observed in this study population. However, some of the observations in the present study may raise awareness in susceptible individuals that lifestyle changes and regular screening in AA can reduce the risk of cardiovascular diseases and other co-existing autoimmune inflammatory condition-IR, dyslipidemia, and hypertension.

背景:斑秃(AA)是炎症性、非持续性脱发的最常见原因,涉及身体的毛发区域。AA的病因仍然不确定;然而,遗传、环境和自身免疫起着一定的作用。新的理论,如氧化理论、HPA轴激活,最后,炎症细胞因子如白细胞介素1(IL1)、肿瘤坏死因子α、干扰素γ、IL-2 IL-4和MIF的作用,被认为对AA和代谢综合征(MS)都有贡献。目的:评估临床诊断的AA病例中MS(NCEP ATP III标准)的关联程度,并与对照组进行比较。材料和方法:选取年龄/性别相似的AA患者和对照组(每组106人)。进行了人体测量、血糖估计、静脉血样本中的脂质分布估计和血压测量。结果:AA 9/106例(8.47%)和健康对照8/106例(7.54%)的MS患病率几乎相似,差异无统计学意义(P=1)。在MS的所有组成部分中,腰围(WC)(中心性肥胖)是最常见的参数(100%的病例)。在对照组中,最高收缩压(SBP)是最常见的参数(77.78%的对照组)。AA与较高水平的SBP、舒张压(DBP)、WC(尽管不显著)和低水平的高密度脂蛋白胆固醇有关,这是唯一显著的相关性。结论:在本研究人群中观察到多发性硬化症的发生与AA患者胰岛素抵抗(IR)的证据之间没有显著相关性。然而,本研究中的一些观察结果可能会提高易感人群的意识,即生活方式的改变和AA的定期筛查可以降低心血管疾病和其他共存的自身免疫炎症性疾病IR、血脂异常和高血压的风险。
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引用次数: 0
Effect of Platelet-Rich Plasma and other Key Factors on Hair Follicle Preservation. 富含血小板的血浆和其他关键因素对毛囊保存的影响。
Q2 Medicine Pub Date : 2023-03-01 Epub Date: 2023-07-28 DOI: 10.4103/ijt.ijt_65_22
Rattapon Thuangtong, Pichanee Chaweekulrat, Kanchalit Thanomkitti, Daranporn Triwongwaranat, Chuda Rujitharanawong

Background: Hair graft preservation is an important factor that influences graft survival in hair transplantation.

Objective: To investigate the benefits of adding platelet-rich plasma (PRP), and the effect of different storage solutions and temperatures on hair follicle preservation.

Materials and methods: This randomized-controlled study included 10 androgenetic alopecia patients who underwent hair transplantation. Forty-five hair grafts were collected from each patient and then randomized to 8 different culture conditions for 7 days. Hair grafts were cultured in Williams' Medium E or Ringer's lactate solution (RLS) at either 4°C or 37°C, and with or without 10% PRP supplementation.

Results: In vitro hair growth in Williams' Medium E was significantly greater than in RLS. The 37°C temperature condition was found to be significantly better than the 4°C condition. The growth of hair grafts cultured with PRP was not significance difference from those without PRP. However, immunofluorescence staining for cytokeratin 15 showed greater expression in hair graft cultured with PRP.

Conclusion: PRP may have a beneficial effect for preserving the viability of hair grafts. Williams' Medium E and 37°C temperature were found to be superior to RLS and 4°C relative to hair follicle growth in organ culture.

背景:植发保存是影响植发成活率的重要因素。目的:探讨添加富血小板血浆(PRP)的益处,以及不同储存溶液和温度对毛囊保存的影响。材料和方法:这项随机对照研究包括10名接受毛发移植的雄激素性脱发患者。从每位患者身上收集45根毛发移植物,然后将其随机分配到8种不同的培养条件下,持续7天。毛发移植物在4°C或37°C的Williams培养基E或Ringer乳酸溶液(RLS)中培养,添加或不添加10%PRP。结果:Williams培养基E的体外毛发生长显著高于RLS培养基。发现37°C的温度条件明显优于4°C的条件。用PRP培养的移植物的生长与未用PRP的移植物没有显著差异。然而,细胞角蛋白15的免疫荧光染色在用PRP培养的毛发移植物中显示出更高的表达。结论:PRP对保持植发组织的活力有一定的作用。在器官培养中,Williams培养基E和37°C的温度优于RLS和4°C的毛囊生长。
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引用次数: 0
Proposition of a New Terminology of Senile Alopecia: Physiologic Alopecia. 老年性脱发新术语的提出:生理性脱发。
Q2 Medicine Pub Date : 2023-01-01 Epub Date: 2023-04-19 DOI: 10.4103/ijt.ijt_54_21
Yazid Bourezane, Ines Bourezane
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引用次数: 0
Positioning of Low Alcohol or Alcohol-Free Minoxidil Formulation for the Management of Androgenetic Alopecia: Indian Perspective. 低酒精或无酒精米诺地尔制剂在雄激素性脱发治疗中的定位:印度人的观点。
Q2 Medicine Pub Date : 2023-01-01 Epub Date: 2023-04-19 DOI: 10.4103/ijt.ijt_54_22
Satish Udare, Anita Baruah, Anurag Mathur, T R Dayananda, Kapil Jain, Manas Ranjan Puhan, Pawan Bajaj, Richa Sharma, Sanjay Ramanbhai Gamit, V Ramesh, V Venugopal, Vignesh Karthik, Monil Yogesh Neena Gala, Snehal Muchhala, Amey Mane

Topical minoxidil is used for treating different hair disorders. Even though it is an effective therapy, many patients show poor compliance due to the cost, side effects, and duration of treatment. Topical minoxidil is the mainstay treatment for androgenetic alopecia (AGA). Recently, low alcohol or alcohol-free topical minoxidil formulation has proven to be an alternative for patients suffering from AGA, including those with poor compliance with other therapies. Thus, the current article provides the positioning of low alcohol or alcohol-free topical minoxidil to manage AGA in Indian clinical practice.

局部米诺地尔用于治疗不同的头发疾病。尽管这是一种有效的治疗方法,但由于治疗的成本、副作用和持续时间,许多患者的依从性较差。局部米诺地尔是治疗雄激素性脱发(AGA)的主要药物。最近,低酒精或无酒精的局部米诺地尔制剂已被证明是AGA患者的替代品,包括那些对其他疗法依从性差的患者。因此,目前的文章提供了低度或无酒精局部米诺地尔在印度临床实践中管理AGA的定位。
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引用次数: 0
An Updated Review on Current Treatment of Alopecia Areata and Newer Therapeutic Options. 目前斑秃治疗的最新进展和新的治疗方案。
Q2 Medicine Pub Date : 2023-01-01 Epub Date: 2023-04-19 DOI: 10.4103/ijt.ijt_28_21
Karan Malhotra, Bhushan Madke

Alopecia areata (AA) is a dermatological disease that causes nonscarring hair loss. It can occur at any age and has an unpredictable and variable evolution in individuals. The aim of this review is to provide an update on the novel therapies currently being used, as well as upcoming therapeutic options in the treatment of AA.

斑秃(AA)是一种导致非持续性脱发的皮肤病。它可以发生在任何年龄,并且在个体中具有不可预测和可变的进化。这篇综述的目的是提供目前正在使用的新疗法的最新情况,以及即将到来的AA治疗方案。
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引用次数: 2
Slivers of Hair - A Clue to Uncover Silver Hair Syndromes. 脱发——揭开银发综合征的线索。
Q2 Medicine Pub Date : 2023-01-01 Epub Date: 2023-04-19 DOI: 10.4103/ijt.ijt_181_20
Nivetha Ganeshan, Muthukumaran Rajaram, Madhavan Ramamoorthy, Bharathi Sukumar

Silver hair syndromes (SHS) consist of rare autosomal recessive disorders, Chediak-Higashi syndrome (CHS), Griscelli syndrome (GS), and Elejalde disease. CHS is a disorder of vesicle trafficking; characterized by silvery hair, diffuse pigment dilution, immunodeficiency, bleeding diathesis, neurological manifestations, and an accelerated phase due to lymphohistiocytic infiltration. GS is characterized by hypopigmentation of skin and hair, with large clumps of pigment in the hair shaft. There are three types of GS. GS1 and GS2 show neurologic and hematologic impairments; GS3 is restricted to the skin. Some authors suggest that Elejalde syndrome is synonymous with GS Type 1. Here, we report two cases who presented with silver-gray hair but with varied clinical manifestations. With a light microscopic examination of the hair and peripheral smear, a diagnosis has been made. This report highlights the importance of hair shaft microscopy, an inexpensive, noninvasive, and simple tool in the diagnosis of SHS.

银发综合征(SHS)包括罕见的常染色体隐性遗传疾病、Chediak-Higashi综合征(CHS)、Griscelli综合征(GS)和Elejalde病。CHS是一种囊泡运输障碍;其特征为银色头发、弥漫性色素稀释、免疫缺陷、出血素质、神经系统表现以及淋巴组织细胞浸润导致的加速期。GS的特征是皮肤和头发色素沉着不足,发干中有大量色素团。GS有三种类型。GS1和GS2表现为神经和血液系统损伤;GS3仅限于皮肤。一些作者认为Elejalde综合征是GS 1型的同义词。在此,我们报告了两例患者,他们的头发呈银灰色,但临床表现各异。通过对头发和外周涂片的光镜检查,已经做出了诊断。这份报告强调了发干显微镜的重要性,这是一种廉价、无创和简单的SHS诊断工具。
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引用次数: 0
Hair Regrowth with Novel Hemp Extract: A Case Series. 新型大麻提取物头发再生:案例系列。
Q2 Medicine Pub Date : 2023-01-01 Epub Date: 2023-04-19 DOI: 10.4103/ijt.ijt_34_22
Gregory Luke Smith

Introduction: The endocannabinoid system (ECS), discovered in the 1990s, is a system involved with maintaining cellular homeostasis by down-regulating the damaging inflammatory responses and upregulating regenerative processes. Cannabidiol (CBD), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV) are all phytocannabinoids found in varying quantities in hemp extract. These three cannabinoids have novel therapeutic effects on hair regrowth through the ECS. The method of action is different from and synergistic with current hair regrowth therapies. The three cannabinoids are fat-soluble and poorly absorbed past the epidermis, but topical application easily reaches hair follicles where they act as partial or full CB1 antagonist and agonist of transient receptor potential vanilloid-1 (TRPV1) and vanilloid receptor-4 (TRPV4). All these ECS receptors relate to hair follicle function. Blocking the CB1 receptor on the hair follicle has been shown to result in hair shaft elongation; in addition, the hair follicle cycle (anagen, catagen, and telogen phases) is controlled by TRPV1. The effects of CBD on hair growth are dose dependent and higher doses may result in premature entry into the catagen phase through a different receptor known as TRPV4. CBD has also been shown to increase Wnt signaling, which causes dermal progenitor cells to differentiate into new hair follicles and maintains anagen phase of the hair cycle.

Objective: This study was conducted on subjects with androgenetic alopecia (AGA), as follow-up to a prior published study using hemp extract high in CBD without CBDV or THCV. That study showed an average 93.5% increase in hair numbers after 6 months of use. This subsequent study is being done to determine if daily topical application of a hemp-oil high in CBD, THCV, and CBDV concentrations would result in improved hair regrowth in the area of the scalp most affected by AGA.

Materials and methods: A case series study was done of 31 (15 men and 16 women, 27 Caucasian, 2 Asian, and 1 mixed race) subjects with AGA. They used a once-daily topical hemp extract formulation, averaging about 33 mg/day for 6 months. A hair count of the greatest area of alopecia was carried out before treatment was started and again after 6 months of treatment. To facilitate consistent hair count analysis, a permanent tattoo was placed at the point for maximum hair loss on the scalp. The subjects were also asked to qualitatively rate their psychosocial perception of "scalp coverage" improvement after the study was completed. The qualitative scale included "very unhappy," "unhappy," "neutral," "happy," and "very happy." The subjects were photographed in a standard manner before and after the study. The photographs were compared for improvements in "scalp coverage" by an independent physician. The qualitative scale included "none," "mild," "moderate," and "extensive" improvement of scalp coverage.

引言:内源性大麻素系统(ECS)于20世纪90年代被发现,是一个通过下调破坏性炎症反应和上调再生过程来维持细胞稳态的系统。大麻二酚(CBD)、四氢大麻酚(THCV)和大麻素(CBDV)都是大麻提取物中含量不同的植物大麻素。这三种大麻素通过ECS对头发再生具有新的治疗作用。该作用方法与目前的头发再生疗法不同,并具有协同作用。这三种大麻素是脂溶性的,通过表皮吸收很差,但局部应用很容易到达毛囊,在毛囊中它们作为瞬时受体电位香草素-1(TRPV1)和香草素受体-4(TRPV4)的部分或全部CB1拮抗剂和激动剂。所有这些ECS受体都与毛囊功能有关。阻断毛囊上的CB1受体已被证明会导致发干伸长;此外,毛囊周期(生长期、衰退期和休止期)由TRPV1控制。CBD对头发生长的影响是剂量依赖性的,更高的剂量可能导致通过一种称为TRPV4的不同受体过早进入紧张期。CBD还被证明可以增加Wnt信号传导,使真皮祖细胞分化为新的毛囊,并维持头发周期的生长期。目的:本研究针对雄激素性脱发(AGA)受试者,作为先前发表的一项研究的后续研究,该研究使用CBD含量高的大麻提取物,不含CBDV或THCV。该研究显示,使用6个月后,头发数量平均增加93.5%。这项后续研究旨在确定每天局部施用CBD、THCV和CBDV浓度高的大麻油是否会改善受AGA影响最严重的头皮区域的头发再生。材料和方法:对31名AGA受试者(15名男性和16名女性、27名高加索人、2名亚洲人和1名混血)进行了一项病例系列研究。他们使用了一种每天一次的局部大麻提取物配方,6个月内平均约33毫克/天。在治疗开始前和治疗6个月后,对脱发最大区域进行毛发计数。为了便于进行一致的头发数量分析,在头皮上最大程度脱发的部位放置了一个永久性纹身。研究完成后,受试者还被要求对他们对“头皮覆盖”改善的心理社会感知进行定性评价。定性量表包括“非常不快乐”、“不快乐”,“中性”、“快乐”和“非常快乐”。受试者在研究前后以标准的方式拍照。一位独立医生对这些照片的“头皮覆盖率”进行了比较。定性量表包括头皮覆盖率的“无”、“轻度”、“中度”和“广泛”改善。结果:结果显示,所有受试者都有一些再生。这一比例从31.25%(16至21根头发)到2000%(1至21根毛发)不等。男性的平均增长率为246%(15.07根毛发/cm2),女性为127%(16.06根毛发/cm3),具有统计学意义。无不良反应报告。所有受试者对脱发影响的心理社会感知评分为“快乐”或“非常快乐”。对照片的独立审查显示,所有受试对象的头皮覆盖率都有“轻度”到“广泛”的改善。结论:尽管治疗效果的确切机制尚不清楚,但THCV和CBDV最有可能作为完全CB1受体中性拮抗剂发挥作用,CBD最有可能是部分CB1受体拮抗剂,并可能通过Wnt信息传递发挥作用。所有三种大麻素都作为TRPV1激动剂发挥作用。通过薄荷提取物添加薄荷醇可能是通过促进生长期的快速开始起作用的。这种局部大麻制剂优于口服非那雄胺、5%米诺地尔每日一次泡沫和单独的CBD局部提取物。由于这种大麻提取物的作用机制与非那雄胺和米诺地尔完全不同,因此可以与这些现有药物联合使用,并有望产生协同作用。然而,这种组合的安全性和有效性有待评估。
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引用次数: 0
Mesotherapy with Bicalutamide: A New Treatment for Androgenetic Alopecia. 比卡鲁胺介导治疗雄激素性脱发的新方法。
Q2 Medicine Pub Date : 2023-01-01 Epub Date: 2023-04-19 DOI: 10.4103/ijt.ijt_78_21
Alba Gomez-Zubiaur, Juan Jose Andres-Lencina, Víctor Cabezas, Cristina Corredera, Fabio di Brisco, Blanca Ferrer, Ana Rodriguez-Villa, Daniela Subiabre-Ferrer, Cristian Valenzuela, David Vega Diez, Jose Maria Ricart

Bicalutamide is a selective androgen receptor antagonist. To date, it has been used orally with good efficacy results, but not in mesotherapy. In our center, we assessed whether patients undergoing bicalutamide mesotherapy showed positive responses and tolerated the local administration of bicalutamide. Six premenopausal women, with a mean age of 35.7 years and clinical diagnosis of Olsen Grade II or III female androgenetic alopecia accompanied by significant seborrhea were treated with 1 ml bicalutamide 0.5% mesotherapy. Three monthly sessions were performed. A subtle improvement in hair density was described after the third session. The overall satisfaction of the patients with the treatment was 6.3, on a scale of 1-10. Premenopausal women require several therapeutic approaches to combat severe androgenetic alopecia. Our data showed that bicalutamide mesotherapy was well tolerated and welcomed by the patients; we, therefore, provide a new tool for the management of this pathology.

比卡鲁胺是一种选择性雄激素受体拮抗剂。迄今为止,它已被口服使用,疗效良好,但尚未用于中位治疗。在我们的中心,我们评估了接受比卡鲁胺中间治疗的患者是否表现出阳性反应并耐受局部给药比卡鲁胺。6名绝经前妇女,平均年龄35.7岁,临床诊断为Olsen II级或III级女性雄激素性脱发并伴有严重脂溢,接受1ml 0.5%比卡鲁胺间皮治疗。每月进行三次会议。在第三次治疗后,描述了头发密度的细微改善。患者对治疗的总体满意度为6.3,评分标准为1-10。绝经前妇女需要几种治疗方法来对抗严重的雄激素性脱发。我们的数据显示,比卡鲁胺中间疗法耐受性良好,受到患者的欢迎;因此,我们为这种病理学的管理提供了一种新的工具。
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引用次数: 0
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International Journal of Trichology
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