{"title":"Constructive Discussion about The Theory of Immortality of the Book of “The Physics of Immortality’’","authors":"Maher Ali Rusho","doi":"10.18483/ijsci.2643","DOIUrl":"https://doi.org/10.18483/ijsci.2643","url":null,"abstract":"","PeriodicalId":14423,"journal":{"name":"International journal of sciences","volume":"299302 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77886096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Carrot ( Daucus carota L.) is an economically important vegetable crop that contains several health-promoting phytochemicals. Carrot seed extracts help in cardio-protection, muscle contraction regulation, regulating the total cholesterol and triglyceride high-density lipoprotein and very-low-density lipoproteins. The objective of this study was to examine the effect of carrot seed priming with different concentrations of illite solution. Although the yield of carrot sprouts was not significantly increased, the concentration of total mineral and total free amino acid of a few sprout samples were raised with illite treatment. Furthermore, the content of functional amino acids like γ-amino-n-butyric acid was improved in the illite-treated carrot sprouts. The results showed that illite treatment could offer a good option to enhance the quality of carrot sprouts.
{"title":"Effect of Illite Treatment on the Yield and Quality Characteristics of Germinated Carrot Seeds","authors":"Il-do Kim, Dong-Young Im, J. Kwon","doi":"10.18483/ijsci.2551","DOIUrl":"https://doi.org/10.18483/ijsci.2551","url":null,"abstract":": Carrot ( Daucus carota L.) is an economically important vegetable crop that contains several health-promoting phytochemicals. Carrot seed extracts help in cardio-protection, muscle contraction regulation, regulating the total cholesterol and triglyceride high-density lipoprotein and very-low-density lipoproteins. The objective of this study was to examine the effect of carrot seed priming with different concentrations of illite solution. Although the yield of carrot sprouts was not significantly increased, the concentration of total mineral and total free amino acid of a few sprout samples were raised with illite treatment. Furthermore, the content of functional amino acids like γ-amino-n-butyric acid was improved in the illite-treated carrot sprouts. The results showed that illite treatment could offer a good option to enhance the quality of carrot sprouts.","PeriodicalId":14423,"journal":{"name":"International journal of sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81560209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Silver Diamine Fluoride in Arresting Dental Caries","authors":"Myung Seo Seok","doi":"10.18483/ijsci.2575","DOIUrl":"https://doi.org/10.18483/ijsci.2575","url":null,"abstract":"","PeriodicalId":14423,"journal":{"name":"International journal of sciences","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81984114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vinicius Costa Lopes, Maycow Douglas Arantes, André Luiz Coelho Pereira, Bruno Vita Ricci, Mateus Henrique da Silva Faria, Andressa Hellen Nora da Silva, Vinicius Trevizam Soares
{"title":"Penile Cancer: Case Report and Literature Review","authors":"Vinicius Costa Lopes, Maycow Douglas Arantes, André Luiz Coelho Pereira, Bruno Vita Ricci, Mateus Henrique da Silva Faria, Andressa Hellen Nora da Silva, Vinicius Trevizam Soares","doi":"10.18483/ijsci.2625","DOIUrl":"https://doi.org/10.18483/ijsci.2625","url":null,"abstract":"","PeriodicalId":14423,"journal":{"name":"International journal of sciences","volume":"185 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80689673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Etienne Téhia Kouakou, P. Marnotte, T. Le Bourgeois
{"title":"Weediness of the Cotton Crop in Cote D'Ivoire in 2014","authors":"Etienne Téhia Kouakou, P. Marnotte, T. Le Bourgeois","doi":"10.18483/ijsci.2614","DOIUrl":"https://doi.org/10.18483/ijsci.2614","url":null,"abstract":"","PeriodicalId":14423,"journal":{"name":"International journal of sciences","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83922563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. O. Aremu, Ipuole Emmanuel Achuri, S. C. Ortutu, Mary Omolola Omosebi, A. Usman, O. J. Oko, L. Labaran
: Sorghum ( Sorghum bicolor ) is an underutilized oil-bearing seed found in Nigeria. The fatty acid, phospholipids and phytosterols composition of germinated and non-germinated seed of Sorghum bicolor were evaluated using standard analytical techniques. The result showed that the most concentrated fatty acids (%) found in the geminated and non-germinated oils were linoleic acid (41.16, 59.45), oleic acid (33.80, 23.05), palmitic acid (18.20, 10.68) and stearic acid (2.35, 1.72). The fatty acids composition of the germinated and non-germinated oils contained a healthy mixture of all the types of saturated and unsaturated fatty acids. The polyunsaturated/saturated index (P/S) was 2.12 % and 3.82 % for germinated and non-germinated oils, respectively. The most prominent phospholipids (mg/100 g) found in the germinated seed oil was phosphatidylcholine (23.86) followed by phosphatidylethanolamine (9.22) and phosphatidylinositol (9.08) while the most prominent in the non-germinated seed oil was phosphatidylcholine (32.39) followed by phosphatidylethanolamine (13.03) and lysophosphatidylcholine (13.07). The high value of phosphatidylcholine showed that Sorghum bicolor may help in protecting the liver from disease and hepatitis. The total phytosterols for germinated and non-germinated were (45.93 mg/100 g and 56.69 mg/100 g), respectively. This suggests that Sorghum bicolor lipid is a good source of food supplement or dietary and health benefits to human.
{"title":"Lipid Composition of Germinated and Non-Germinated Sorghum (Sorghum bicolor) Found in Nasarawa State, Nigeria","authors":"M. O. Aremu, Ipuole Emmanuel Achuri, S. C. Ortutu, Mary Omolola Omosebi, A. Usman, O. J. Oko, L. Labaran","doi":"10.18483/ijsci.2541","DOIUrl":"https://doi.org/10.18483/ijsci.2541","url":null,"abstract":": Sorghum ( Sorghum bicolor ) is an underutilized oil-bearing seed found in Nigeria. The fatty acid, phospholipids and phytosterols composition of germinated and non-germinated seed of Sorghum bicolor were evaluated using standard analytical techniques. The result showed that the most concentrated fatty acids (%) found in the geminated and non-germinated oils were linoleic acid (41.16, 59.45), oleic acid (33.80, 23.05), palmitic acid (18.20, 10.68) and stearic acid (2.35, 1.72). The fatty acids composition of the germinated and non-germinated oils contained a healthy mixture of all the types of saturated and unsaturated fatty acids. The polyunsaturated/saturated index (P/S) was 2.12 % and 3.82 % for germinated and non-germinated oils, respectively. The most prominent phospholipids (mg/100 g) found in the germinated seed oil was phosphatidylcholine (23.86) followed by phosphatidylethanolamine (9.22) and phosphatidylinositol (9.08) while the most prominent in the non-germinated seed oil was phosphatidylcholine (32.39) followed by phosphatidylethanolamine (13.03) and lysophosphatidylcholine (13.07). The high value of phosphatidylcholine showed that Sorghum bicolor may help in protecting the liver from disease and hepatitis. The total phytosterols for germinated and non-germinated were (45.93 mg/100 g and 56.69 mg/100 g), respectively. This suggests that Sorghum bicolor lipid is a good source of food supplement or dietary and health benefits to human.","PeriodicalId":14423,"journal":{"name":"International journal of sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82224774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quadratic Residuacity: Intro to Advance Number Theory","authors":"Maher Ali Rusho","doi":"10.18483/ijsci.2639","DOIUrl":"https://doi.org/10.18483/ijsci.2639","url":null,"abstract":"","PeriodicalId":14423,"journal":{"name":"International journal of sciences","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83026763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Population Pharmacokinetics of Naoqingzhiming Tablets a Novel Drug for Vascular Dementia in Healthy Chinese Subjects","authors":"Xin Liu, Ping-ping Lin, Ting Li, Ping Shi, Chenjing Wang, Lu-jin Li, Yu Cao","doi":"10.18483/ijsci.2594","DOIUrl":"https://doi.org/10.18483/ijsci.2594","url":null,"abstract":"","PeriodicalId":14423,"journal":{"name":"International journal of sciences","volume":"531 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83428336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Programmed Death Ligand-1(PD-L1) is an important target to drive T cell dysfunction when it connects with Programmed Death-1(PD-1), leading to immune escape of tumor cells, thus anti-PD-L1 antibody shows a promising prospect in the treatment of tumor. In order to construct a large natural antibody library, we collected a large number of lymphocytes of adults and children. The light chain and Fd genes of antibody were amplified by PCR, and the Fab phage antibody library with a library capacity of 4.27×10 9 was constructed. The insertion rates of the light chain library and the Fab library were 90% and 70%, respectively. The cloned sequences identified by PCR showed that all the sequences analyzed were unique, and the amino acid sequences of the CDR regions were diverse, which proved that there was good diversity in the antibody library. The positive clones that bind to PD-L1 were screened by phage ELISA, PCR identification and sequence analysis. In the end, two high-affinity positive clones were determined. The successful construction of this natural phage antibody library provided an effective method for screening human PD-L1 antibodies, which was expected to screen humanized antibodies against various antigens.
程序性死亡配体-1(Programmed Death Ligand-1, PD-L1)与程序性死亡配体-1(Programmed Death-1, PD-1)结合，是驱动T细胞功能障碍的重要靶点，导致肿瘤细胞的免疫逃逸，因此抗PD-L1抗体在肿瘤治疗中具有广阔的应用前景。为了构建庞大的天然抗体文库，我们采集了大量成人和儿童淋巴细胞。通过PCR扩增抗体轻链和Fd基因，构建库容量为4.27×10 9的Fab噬菌体抗体文库。轻链文库和Fab文库的插入率分别为90%和70%。经PCR鉴定的克隆序列显示，所分析的序列均具有唯一性，且CDR区氨基酸序列具有多样性，证明抗体文库具有良好的多样性。通过噬菌体ELISA、PCR鉴定和序列分析筛选出与PD-L1结合的阳性克隆。最终获得两个高亲和力阳性克隆。该天然噬菌体抗体文库的成功构建为筛选人PD-L1抗体提供了一种有效的方法，有望用于筛选各种抗原的人源化抗体。
{"title":"Construction of a Natural Human Fab Phage Antibody Library and Screening of Phage Antibody against PD-L1","authors":"Jiangtao Gu, Raoqing Guo, Ligang Zhang, Ning Deng","doi":"10.18483/ijsci.2561","DOIUrl":"https://doi.org/10.18483/ijsci.2561","url":null,"abstract":": Programmed Death Ligand-1(PD-L1) is an important target to drive T cell dysfunction when it connects with Programmed Death-1(PD-1), leading to immune escape of tumor cells, thus anti-PD-L1 antibody shows a promising prospect in the treatment of tumor. In order to construct a large natural antibody library, we collected a large number of lymphocytes of adults and children. The light chain and Fd genes of antibody were amplified by PCR, and the Fab phage antibody library with a library capacity of 4.27×10 9 was constructed. The insertion rates of the light chain library and the Fab library were 90% and 70%, respectively. The cloned sequences identified by PCR showed that all the sequences analyzed were unique, and the amino acid sequences of the CDR regions were diverse, which proved that there was good diversity in the antibody library. The positive clones that bind to PD-L1 were screened by phage ELISA, PCR identification and sequence analysis. In the end, two high-affinity positive clones were determined. The successful construction of this natural phage antibody library provided an effective method for screening human PD-L1 antibodies, which was expected to screen humanized antibodies against various antigens.","PeriodicalId":14423,"journal":{"name":"International journal of sciences","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85584206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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