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Case Report: Gastric diverticulum: an uncommon endoscopic finding in a case of halitosis 病例报告:胃憩室:一个罕见的内镜发现的病例口臭
Pub Date : 2018-05-15 DOI: 10.4314/IJMU.V13I1.5
Vipul D Yagnik
A gastric diverticulum is an outpouching of the stomach or gastric wall. It is an  uncommon anatomical abnormality and can present with a variety of symptoms. Here, we present an interesting case of a gastric diverticulum along with halitosis, which was diagnosed on esophagogastroduodenoscopy (EGD) and was managed successfully with conservative treatment, and we review the relevant literature. Surgery is required in  case of failed medical management and severe complications. Key words : Gastric diverticulum; Halitosis; esophagogastroduodenoscopy; conservative; Surgery
胃憩室是胃或胃壁的突起。这是一种罕见的解剖异常,可呈现多种症状。在此,我们报告一个有趣的胃憩室合并口臭的病例,该病例在食管胃十二指肠镜检查(EGD)中被诊断出来,并通过保守治疗成功地进行了治疗,我们回顾了相关文献。在医疗管理失败和严重并发症的情况下,需要手术。关键词:胃憩室;口臭;esophagogastroduodenoscopy;保守的;手术
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引用次数: 1
Lipemic serum: A quick clue to diagnose hyperlipidemic acute pancreatitis 血脂血清:诊断高脂血症急性胰腺炎的快速线索
Pub Date : 2018-05-15 DOI: 10.4314/IJMU.V13I1.6
Vipul D Yagnik, Vismit P. Joshipura
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引用次数: 0
Correlation between hyperuricemia and lipid profile in untreated dyslipidemic patients 未经治疗的血脂异常患者高尿酸血症与血脂的相关性
Pub Date : 2018-05-15 DOI: 10.4314/IJMU.V13I1.2
S. Suneja, Rajani Kumawat, R. Saxena
There are a number of epidemiological studies that suggest the association of cardiovascular diseases and uric acid but very few studies highlight the direct association of deranged lipid profile with uric acid levels. The present study was  indented to find out if any association exists between hyperuricemia and dyslipidemia. Blood samples were collected from healthy controls (n=70) and patients with dyslipidemia (n=70) who were not receiving any treatment for  dyslipidemia. These samples were processed for estimating lipid profile and uric acid levels. The parameters in the two groups were compared. Correlation between different parameters was calculated by Pearson correlation analysis in both the groups. Uric acid levels (6.40 ± 1.27 vs 4.89 ± 0.21 mg/dl, P<0.001) were significantly higher in patients as compared to those in controls. There was significant increase in the levels of total cholesterol (TC), triglycerides (TAGs), LDL-C, VLDL-C, non-HDL cholesterol (P<0.001 in each case), in patients of dyslipidemia. However, significant decrease in the levels of HDL-C (P<0.001) was seen in patients compared to controls. LDL-C/HDL-C ratio (P<0.001), TC/HDL-C ratio (P<0.001) and TAG/HDL-C ratio (P<0.001) were also significantly increased in dyslipidemic subjects when compared to controls. Uric acid had significant  correlations with TC (r=0.334, P<0.001), TAGs (r = 0.288, P<0.001), LDL-C (r = 0.241, P<0.001), VLDL-C (r= 0.158, P<0.001) and HDL-C (r= –0.652, P<0.001) in patients. Results of this study imply that there is higher association of  hyperuricemia in dyslipidemic patients than normal subjects. Therefore treatment of underlying hyperuricemia should be an important aspect in planning the treatment strategy for dyslipidemia to reduce the cardiovascular morbidity. Keywords : Cardiovascular disease; Coronary artery disease; Dyslipidemia; Hyperuricemia; Lipid ratio
有许多流行病学研究表明心血管疾病与尿酸有关,但很少有研究强调血脂紊乱与尿酸水平的直接联系。本研究旨在找出高尿酸血症和血脂异常之间是否存在任何关联。血液样本采集自健康对照(n=70)和未接受任何血脂异常治疗的血脂异常患者(n=70)。这些样本经过处理以估计血脂和尿酸水平。比较两组患者的各项指标。采用Pearson相关分析计算两组各参数之间的相关性。与对照组相比,患者的尿酸水平(6.40±1.27 vs 4.89±0.21 mg/dl, P<0.001)显著升高。血脂异常患者的总胆固醇(TC)、甘油三酯(TAGs)、LDL-C、VLDL-C、非hdl - c水平均显著升高(P<0.001)。然而,与对照组相比,患者的HDL-C水平显著下降(P<0.001)。血脂异常组LDL-C/HDL-C比值(P<0.001)、TC/HDL-C比值(P<0.001)和TAG/HDL-C比值(P<0.001)均显著高于对照组。尿酸与患者TC (r=0.334, P<0.001)、TAGs (r= 0.288, P<0.001)、LDL-C (r= 0.241, P<0.001)、VLDL-C (r= 0.158, P<0.001)、HDL-C (r= -0.652, P<0.001)有显著相关性。本研究结果提示血脂异常患者高尿酸血症的相关性高于正常人。因此,治疗潜在的高尿酸血症应是规划血脂异常治疗策略的一个重要方面,以减少心血管疾病的发病率。关键词:心血管疾病;冠状动脉疾病;血脂异常;高尿酸血;脂质比
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引用次数: 2
Calcium homeostasis during pregnancy and lactation: role of vitamin D supplementation 孕期和哺乳期钙稳态:维生素D补充的作用
Pub Date : 2018-05-15 DOI: 10.4314/ijmu.v13i1.4
R. K. Marya
Pregnancy and lactation cycle is a period of considerable strain on maternal calcium homeostasis. A number of adaptive mechanisms involve increased intestinal calcium absorption, renal calcium conservation and changes in bone metabolism. These adaptations are mediated through changes in the secretion of various  calciotropic hormones [1,25(OH)2 D3, parathormone, and calcitonin]. In all of these adaptive mechanisms, vitamin D is involved directly or indirectly. Now, it is being realized that not only darkskinned but also even Caucasian women tend to go into vitamin D deficiency during pregnancy. Adverse health outcomes such as preeclampsia, low birth-weight, neonatal hypocalcemia, poor postnatal growth, bone fragility, and increased incidence of autoimmune diseases have been linked to low vitamin D levels during pregnancy and infancy. Vitamin D deficiency seems to be a public health problem even in 2018. Most of the experts in the field are convinced that women need extra amounts of vitamin D during pregnancy and lactation. The amount of vitamin D that is required for optimum calcium homeostasis in this phase of life is still controversial. Studies are under way to establish the recommended daily doses of vitamin D in pregnant and lactating women. Key words : Vitamin D deficiency; Pregnancy; Lactation; Vitamin D supplementation
妊娠和哺乳期是一个对母体钙稳态相当紧张的时期。一些适应性机制包括增加肠道钙吸收,肾脏钙保存和骨代谢的变化。这些适应是通过各种促钙激素[1,25(OH)2 D3,旁腺激素和降钙素]的分泌变化介导的。在所有这些适应机制中,维生素D都直接或间接地参与其中。现在,人们意识到,不仅是深肤色的女性,就连白人女性在怀孕期间也容易缺乏维生素D。妊娠期和婴儿期维生素D水平过低与子痫前期、低出生体重、新生儿低钙血症、产后生长不良、骨骼脆弱和自身免疫性疾病发病率增加等不良健康结果有关。即使在2018年,维生素D缺乏似乎也是一个公共卫生问题。该领域的大多数专家都相信,女性在怀孕和哺乳期间需要额外补充维生素D。在生命的这一阶段,维持最佳钙稳态所需的维生素D的量仍然存在争议。目前正在进行研究,以确定孕妇和哺乳期妇女每日维生素D的推荐剂量。关键词:维生素D缺乏症;怀孕;泌乳;补充维生素D
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引用次数: 4
Case Report: Angiomyolipoma of the cervix – report of a rare entity 病例报告:子宫颈血管平滑肌脂肪瘤-罕见病例报告
Pub Date : 2018-02-23 DOI: 10.4314/IJMU.V12I2.4
N. Sarma, R. Srivastava, S. Agnihotri
Angiomyolipoma (AML) is a mesenchymal neoplasm seen usually in the kidney. Few cases of extra renal AML have been documented in various organs including the female genital tract, where the uterus is the most common site. To the best of our knowledge, only 4 cases of AML in the cervix have been reported in the literature. Association of AML with tuberous sclerosis is well known. Presently AML is included in the spectrum of disease entities called PEComa. We report a case of AML without tuberous sclerosis arising from the uterine cervix, which has to be differentiated from lipoleiomyoma. Keywords: Angiomyolipoma; Uterine cervix; PEComas; Uterine tumor
血管平滑肌脂肪瘤(AML)是一种常见于肾脏的间质肿瘤。很少有其他器官发生肾外性急性髓性白血病的病例,包括女性生殖道,其中子宫是最常见的部位。据我们所知,文献中仅报道了4例宫颈AML。AML与结节性硬化症的关联是众所周知的。目前AML被包括在称为PEComa的疾病实体谱中。我们报告一例无结节性硬化症的急性髓性白血病,起源于子宫颈,必须与脂质肌瘤鉴别。关键词:血管肌脂肪瘤;子宫颈癌;PEComas;子宫肿瘤
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引用次数: 1
Letter to the Editor: Myoepithelial carcinoma of the male breast 致编辑的信:男性乳房肌上皮癌
Pub Date : 2018-02-23 DOI: 10.4314/IJMU.V12I2.5
Vipul D Yagnik
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引用次数: 0
Type II perforation of the body of the gallbladder in acalculous cholecystitis: a rare complication of enteric fever 无结石性胆囊炎胆囊体II型穿孔:肠热的罕见并发症
Pub Date : 2018-02-23 DOI: 10.4314/IJMU.V12I2.3
Vipul D Yagnik
Gallbladder perforation is a rare but potentially life-threatening complication of acute cholecystitis with or without gallstones. Enteric fever leading to small bowel perforation is rare, and gallbladder perforation is extremely rare. It requires early and accurate diagnosis. If left untreated, it is associated with high mortality. Clinical diagnosis is often difficult. The most common site of perforation is the fundus; perforation in the body is rare. We report a case of gallbladder perforation as a complication of enteric fever, which presented as acute abdomen and responded very well after cholecystectomy. Although rare and unusual, this case report shows that gallbladder perforation should be considered in patients presenting with acute abdomen and a history of enteric fever. Keywords: Enteric fever; Acalculous cholecystitis; Perforation; Cholecystectomy
胆囊穿孔是急性胆囊炎伴或不伴胆结石的一种罕见但可能危及生命的并发症。肠热导致小肠穿孔是罕见的,胆囊穿孔是极其罕见的。它需要早期和准确的诊断。如果不及时治疗,它会导致高死亡率。临床诊断通常很困难。最常见的穿孔部位是眼底;穿孔在体内是罕见的。我们报告一例胆囊穿孔作为肠道热的并发症,表现为急腹症,并在胆囊切除术后反应很好。虽然罕见和不寻常,本病例报告显示,胆囊穿孔应考虑患者出现急腹症和肠热史。关键词:肠热;Acalculous胆囊炎;穿孔;胆囊切除术
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引用次数: 3
A clinical study on etiology, prognosis, outcome and role of endoscopy in upper gastrointestinal bleed in a tertiary care center 三级医疗中心上消化道出血的病因、预后、结果及内镜作用的临床研究
Pub Date : 2018-02-23 DOI: 10.4314/IJMU.V12I2.2
Yash Shangavi, Jignesh B. Rathod, Vipul D Yagnik
Upper gastrointestinal bleed is defined as bleeding proximal to the ligament of Treitz. The aim of this study was to know the cause of upper GI bleed, prognosis of the patients and role of upper gastrointestinal endoscopy (UGIE) in the management of upper gastrointestinal bleed (UGIB). A study of 140 cases was carried out in the Shree Krishna Hospital and Pramukh Swami Medical College, Karamsad in India between January 2014 and June 2015. All patients were selected by the detailed history and physical examination. Patients with signs and symptoms suggestive of upper GI bleeding such as hematemesis, melena, blood in the nasogastric tubes, and profuse hematochezia were included in the study. Endoscopy was performed in all patients. Rockall scoring system was used to predict the mortality in patients with upper GI bleeding. We use descriptive statistics for analysis. It was found that upper GI bleed was more common in males than females, and was more prevalent in elderly individuals. The most common symptom was found to be hematemesis followed by abdominal pain. The most common cause was portal hypertension, which has a direct correlation with alcohol addiction. UGIE has both diagnostic as well as therapeutic role in UGIB. This study showed that upper GI bleeding was more common in male patients with the most common cause being portal hypertension. We observed that Mallory-Weiss tear had a particular association with NSAIDs. In our study, the Rockall scoring system was seen to predict the mortality in patients with upper GI bleeding. Endoscopy was both diagnostic and therapeutic and endoscopic variceal ligation (EVL/Glue) was performed for esophageal and/fundic varices and adrenaline injection for peptic ulcer bleeding and Mallory-Weiss tear. Keywords: Upper GI bleeding; Endoscopy; Endoscopic variceal ligation; Mallory- Weiss tear
上消化道出血定义为Treitz韧带近端出血。本研究的目的是了解上消化道出血的原因、患者的预后以及上消化道内镜(UGIE)在上消化道出血(UGIB)治疗中的作用。2014年1月至2015年6月,在印度Karamsad的Shree Krishna医院和Pramukh Swami医学院对140例病例进行了研究。所有患者均通过详细病史和体格检查选择。有呕血、黑黑、鼻胃管出血、大量便血等上消化道出血体征和症状的患者被纳入研究。所有患者均行内窥镜检查。采用Rockall评分系统预测上消化道出血患者的死亡率。我们使用描述性统计进行分析。研究发现,上消化道出血在男性中比女性更常见,在老年人中更为普遍。最常见的症状是呕血,其次是腹痛。最常见的原因是门静脉高压,这与酒精成瘾有直接关系。UGIE在UGIB中既有诊断作用,也有治疗作用。本研究显示,上消化道出血在男性患者中更为常见,最常见的原因是门静脉高压。我们观察到Mallory-Weiss撕裂与非甾体抗炎药有特殊的联系。在我们的研究中,Rockall评分系统可以预测上消化道出血患者的死亡率。内镜既是诊断又是治疗,内镜下静脉曲张结扎(EVL/Glue)用于食管和/底静脉曲张,肾上腺素注射用于消化性溃疡出血和mallorie - weiss撕裂。关键词:上消化道出血;内窥镜检查;内镜下静脉曲张结扎;马洛里-韦斯的眼泪
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引用次数: 5
Editorial: Port-site infections due to non-tuberculous mycobacteria (atypical mycobacteria) in laparoscopic surgery 社论:腹腔镜手术中由非结核分枝杆菌(非典型分枝杆菌)引起的端口部位感染
Pub Date : 2018-02-23 DOI: 10.4314/ijmu.v12i2.1
Vipul D Yagnik
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引用次数: 0
Chronic Allium sativum administration alters spontaneous alternation and cyto-architecture of medial prefrontal cortex of adult Wistar rats 慢性给药可改变成年Wistar大鼠内侧前额叶皮层的自发交替和细胞结构
Pub Date : 2017-05-16 DOI: 10.4314/IJMU.V12I1.3
Ngozi Jane Muonagolu, Moses B. Ekong, Innocent A. Edgaha
Intake of herbs and some of their constituents is reported to reduce risks of some diseases, with Allium sativum being one of such. This study was conducted to investigate the effects of Allium sativum extract on the medial prefrontal cortex and neurobehaviour of adult Wistar rats. Twenty-four male Wistar rats were divided into 4 groups (n = 6). Group 1 was the control and received distilled water placebo orally, while groups 2-4 received oral doses of 78 mg/kg, 156 mg/kg and 312 mg/kg Allium sativum extract for 28 days. On day 29, spontaneous alternation behavioural test was carried out, and immediately the rats were anaesthetized (50 mg/kg ketamine hydrochloride IP.) and perfusion-fixed with 10% buffered formalin. The whole brains were removed and the medial prefrontal cortex excised and processed for histomorphologic studies by haematoxylin and eosin, and cresyl fast violet techniques. Neurobehavioural test revealed less spontaneous alternation in 156 mg/kg Allium sativum group, while the prefrontal cortices of the test groups showed hypertrophy, hyperplasia, pyknosis, karyorrhexis, chromatolysis, loss of brain cellular membranes and Nissl substance. The 156 mg/kg Allium sativum group showed altered spontaneous alternation, while cellular pathologic changes were observed in the medial prefrontal cortex of these test groups in a dose dependent sequence. Keywords: Allium sativum ; Medial prefrontal cortex; Neurobehaviour; Histomorphology; Wistar rat
据报道,摄入草药及其某些成分可以降低患某些疾病的风险,葱属植物就是其中之一。本研究旨在探讨葱提取物对成年Wistar大鼠内侧前额叶皮层及神经行为的影响。将24只雄性Wistar大鼠分为4组(n = 6),第1组为对照组,口服蒸馏水安慰剂,第2 ~ 4组分别口服大蒜提取物78、156、312 mg/kg,连续28 d。第29天进行自发交替行为试验,立即麻醉大鼠(50mg /kg盐酸氯胺酮IP), 10%福尔马林缓冲灌注固定。整个大脑被切除,内侧前额叶皮层被切除,并用血红素、伊红和甲酚耐晒紫技术进行组织形态学研究。神经行为学试验显示,156 mg/kg葱组自发性交替较少,各组前额叶皮层出现肥大、增生、固缩、核裂、染色质溶解、脑组织膜和尼氏物质丢失。156 mg/kg大蒜组小鼠自发性交替发生改变,各试验组小鼠内侧前额叶皮层细胞病理改变呈剂量依赖性。关键词:葱;内侧前额皮质;Neurobehaviour;组织形态学;纯种老鼠
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引用次数: 0
期刊
Internet Journal of Medical Update - EJOURNAL
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