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The possible protective effect of Panax ginseng on experimentally induced colchicine myopathy in adult male albino rats: A histological study 人参对实验性诱导的成年雄性白化大鼠秋水仙碱肌病可能的保护作用:组织学研究
Pub Date : 2021-01-01 DOI: 10.4314/ijmu.v14i1.3
Aiman Al-Maathadi, S. Farhan, Jihad A. M. Alzyoud, Aiman Al-Qtaitata
Myopathy is one of the side effects of colchicine, manifested as pain, dysfunction, and weakness of muscles. Ginseng extract antioxidant  and anti-inflammatory activities have been reported in muscular tissue. This study was conducted to investigate whether administration of ginseng ameliorates colchicine-induced skeletal muscles damage in adult male albino rats. Forty adult male albino rats were randomly  divided into four groups (ten/group) – Group I (control group): rats received normal diet and orally given normal saline, Group II: ginseng extract was administered via oral gavage daily for one month at the doses of 300 mg/kg, Group III (Colchicine treated group): rats were  given colchicine (50 μg/kg/day) via oral gavage for one month, and Group IV: concomitant administration of Ginseng and colchicine for one month. Serum creatine kinase (CK) levels were measured, and skeletal muscles specimens were processed for light and electron microscopic examination. Administration of colchicine (group III) showed elevated serum CK, and histologically myofibrillar disarray foci together with cellular infiltration and edema. Group IV showed reduction in most of those manifestations. Concomitant administration of ginseng with colchicine ameliorated most of the symptoms related to colchicine induced-myopathy.
肌病是秋水仙碱的副作用之一,表现为疼痛、功能障碍和肌肉无力。人参提取物在肌肉组织中具有抗氧化和抗炎活性。本研究旨在探讨人参是否能改善秋水仙碱引起的成年雄性白化大鼠骨骼肌损伤。选取成年雄性白化大鼠40只,随机分为4组(10只/组):第一组(对照组):给予正常饮食并口服生理盐水;第二组(秋水仙碱处理组):给予秋水仙碱(50 μg/kg/d)灌胃1个月;第三组(秋水仙碱处理组):给予秋水仙碱(50 μg/kg/d)灌胃1个月;第四组:人参和秋水仙碱同时给予1个月。测定血清肌酸激酶(CK)水平,并对骨骼肌标本进行光镜和电镜检查。秋水仙碱组(III组)显示血清CK升高,组织学上肌纤维紊乱灶伴细胞浸润和水肿。IV组的大多数症状均有所减轻。人参与秋水仙碱同时服用可改善大部分与秋水仙碱诱发的肌病有关的症状。
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引用次数: 1
Seasonality in hyperglycemic emergencies in a Health Facility in Sub-Saharan Africa: The roles of geographic location, infection, and knowledge of diabetes mellitus status 撒哈拉以南非洲卫生机构高血糖急诊的季节性:地理位置、感染和糖尿病状况知识的作用
Pub Date : 2021-01-01 DOI: 10.4314/ijmu.v14i2.4
O. H. Chijioke, Ogochukwu Y. Nwanne, David Samuel Olorunfemi, S. Chinenye
Hyperglycemic emergencies (HEs) are acute complications of diabetes mellitus and they carry high morbidity and mortality. Studies have reported a seasonal pattern in the frequency of occurrence of both types 1 and 2 diabetes mellitus and even Gestational Diabetes Mellitus. No such association has been suggested for HEs. The study was conducted at the Asokoro District Hospital, Located in Abuja, Nigeria to examine a seasonal pattern in the frequency of hyperglycemic emergencies. The initial observation of an obvious fluctuation in the number of admitted cases of hyperglycemic emergencies motivated this prospective study which ran for a period of six years. It involved collecting the relevant information using a questionnaire from all HEs patients admitted to the medical ward from the first of January, 2008 to the 31st of December, 2013. Required investigations were done. The precipitating factors for HEs were looked for. The number of cases per month was noted for each year. The Statistical package used for analysis was STATA version 11. Round the year Abuja Climatic changes were monitored on the website of the Nigerian Meteorological station. Four hundred and fifty-one (451) patients with hyperglycemic emergency were enrolled for this study. Most of the patients, (55%), were in the middle-age bracket. Fifty-six per cent (56%), were not previously known to be living with diabetes mellitus. Infections, particularly of the respiratory and gastrointestinal tracks, were the commonest precipitating factors. Variation in the frequency of HEs was observed, with two peaks: one in April and a smaller peak in December. There is seasonal variation in the frequency of presentation of Hyperglycemic emergencies. This may have been influenced by exogenous factors such as geographic location, infection, and the fact that most of the patients never knew they had diabetes mellitus.
高血糖急症(HEs)是糖尿病的急性并发症,具有很高的发病率和死亡率。研究报告了1型和2型糖尿病甚至妊娠期糖尿病发生频率的季节性模式。没有证据表明HEs与此有关联。这项研究是在尼日利亚阿布贾的Asokoro地区医院进行的,目的是检查高血糖紧急情况发生频率的季节性模式。最初观察到入院的高血糖急诊病例数量有明显波动,这促使了这项为期六年的前瞻性研究。对2008年1月1日至2013年12月31日住院的所有he患者进行问卷调查,收集相关信息。进行了必要的调查。寻找he的诱发因素。记录了每年每月的病例数。用于分析的Statistical包是STATA版本11。尼日利亚气象站的网站全年监测阿布贾的气候变化。451例高血糖急症患者参加了这项研究。大多数患者(55%)为中年人。56%的人以前并不知道自己患有糖尿病。感染,特别是呼吸道和胃肠道感染,是最常见的诱发因素。观察到he频率的变化,有两个高峰:一个在4月,一个较小的高峰在12月。出现高血糖急症的频率有季节变化。这可能受到外源性因素的影响,如地理位置、感染,以及大多数患者从不知道自己患有糖尿病。
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引用次数: 0
Neuroendocrine tumor of the hepatic flexure: a rare colonic tumor 肝屈曲神经内分泌肿瘤:一种罕见的结肠肿瘤
Pub Date : 2019-01-09 DOI: 10.4314/ijmu.v13i2.4
Vipul D Yagnik, Sunil R Prajapati
Neuroendocrine tumors (NETs) are rare, particularly common in the rectum. NETs of the colon (not including the appendix and rectum) are most commonly found in the cecum, and hepatic flexure involvement is rather infrequent. The clinical presentation of colonic NETs is dependent on the primary site. Many are discovered either at the time of screening or during the investigation of abdominal pain or anemia. Here we present a challenging case of a hepatic flexure colonic NETS of 26 -year-old male treated by laparoscopic right hemicolectomy. Keywords: Neuroendocrine tumors; Colonoscopy; Surgery; Immunohistochemical test
神经内分泌肿瘤(NETs)是罕见的,尤其常见于直肠。结肠NETs(不包括阑尾和直肠)最常见于盲肠,累及肝屈曲相当少见。结肠NETs的临床表现取决于原发部位。许多是在筛查时或在腹痛或贫血的调查中发现的。在这里,我们提出一个具有挑战性的情况下,肝脏弯曲结肠NETS的26岁男性腹腔镜右半结肠切除术治疗。关键词:神经内分泌肿瘤;结肠镜检查;手术;免疫组织化学检测
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引用次数: 0
Book Review: Fundamentals of Operative Surgery, 2nd edition 书评:外科手术基础,第二版
Pub Date : 2019-01-09 DOI: 10.4314/ijmu.v13i2.6
S. Hindocha
Book Title: Fundamentals of Operative SurgeryBook Author: Vipul YagnikPublisher: Wolters Kluwer, Year 2019, 435 pages Format: PDF and EPUB, Hardcover ISBN 9789387506817.
书名:外科手术基础作者:维普尔·雅格尼克出版商:威科集团,2019年,435页格式:PDF和EPUB,精装ISBN 9789387506817。
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引用次数: 0
Editorial: Beyond the Numbers. What determines journal quality? 社论:超越数字。是什么决定了期刊的质量?
Pub Date : 2019-01-09 DOI: 10.4314/IJMU.V13I2.1
S. Dawka
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引用次数: 0
Selfmonitoring of blood glucose practices by people living with diabetes who use their personal glucometers in Port Harcourt, Niger Delta Region, Nigeria 尼日利亚尼日尔三角洲地区哈科特港使用个人血糖仪的糖尿病患者自我监测血糖情况
Pub Date : 2019-01-09 DOI: 10.4314/IJMU.V13I2.2
M. Nkpozi, A. Jumbo, N. Unamba, C. Unachukwu, S. Chinenye
Self-monitoring of blood glucose (SMBG) assists persons living with diabetes with the day-to-day behavioral and therapeutic adjustments to their diabetes care. It is a cheaper and more available alternative to glycated haemoglobin (HbA1c) in Nigeria for monitoring glycaemic control. Information on SMBG practices of Nigerians living with diabetes using their personal glucometers is scanty. The aim of the study is to assess the intensity and frequency of SMBG by glucometer owners, and the extent the patients and/or the health care providers (HCP) utilize SMBG to achieve personalized treatment goals via behavioral/treatment adjustments. This was a cross sectional study carried out among persons living with diabetes that accessed diabetes care at the diabetes clinic of the University of Port Harcourt Teaching Hospital (UPTH) and using their personal glucometers. They were consecutively recruited. Data obtained by using intervieweradministered questionnaires were analyzed using SPSS version 20.0, and pvalue <0.05 was considered significant. A total of 128 persons living with diabetes participated in the study of which 40 (31%) were males and 88 (69%) were females; the mean age of the subjects was 52.05 ± 11.24 years with a range of 26–70 years. The majority of the study subjects (72%) were in the active working age group (25–60years). The highest frequency of glucometer use was in the 26 subjects (20%) who checked their blood glucose every morning while 62 (48%) of the subjects checked their blood glucose any morning they felt like. Most of the subjects (60%) did not have any recording device. Glucometer owners were not just the insulin-requiring people living with diabetes as more than half of the subjects, 66 (52%) were on oral anti diabetic drugs (OAD) only. Glucometer ownership was mainly by those that were in the working age group. SMBG protocol (frequency) was variable and SMBG data were not maximally utilized. Keywords: Self-monitoring of blood glucose; Personal glucometer; Diabetes; Blood glucose
自我血糖监测(SMBG)有助于糖尿病患者的日常行为和治疗调整他们的糖尿病护理。在尼日利亚,它是糖化血红蛋白(HbA1c)监测血糖控制的一种更便宜、更可行的替代方法。关于尼日利亚糖尿病患者使用个人血糖仪的SMBG做法的信息很少。该研究的目的是评估血糖仪拥有者的SMBG的强度和频率,以及患者和/或卫生保健提供者(HCP)利用SMBG通过行为/治疗调整来实现个性化治疗目标的程度。这是一项横断面研究,研究对象是在哈科特港大学教学医院(UPTH)糖尿病诊所接受糖尿病护理的糖尿病患者,并使用他们的个人血糖仪。他们被连续招募。采用访谈问卷获得的数据采用SPSS 20.0版进行分析,p值<0.05被认为是显著的。共有128名糖尿病患者参与了这项研究,其中40名(31%)为男性,88名(69%)为女性;患者平均年龄52.05±11.24岁,年龄范围26 ~ 70岁。大多数研究对象(72%)处于积极工作年龄组(25 - 60岁)。使用血糖仪频率最高的是26名(20%)每天早上检查血糖的受试者,而62名(48%)的受试者在他们想要的任何早晨都检查血糖。大多数受试者(60%)没有任何记录设备。血糖仪拥有者不仅仅是需要胰岛素的糖尿病患者,超过一半的受试者,66人(52%)只服用口服抗糖尿病药物(OAD)。拥有血糖仪的主要是工作年龄段的人。SMBG协议(频率)是可变的,SMBG数据没有得到最大限度的利用。关键词:血糖自我监测;个人glucometer;糖尿病;血糖
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引用次数: 0
Letter to Editor: Sister Mary Joseph’s Nodule: A short compilation 致编辑的信:玛丽·约瑟夫修女的结节:一个简短的汇编
Pub Date : 2019-01-09 DOI: 10.4314/IJMU.V13I2.5
S. Ergen
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引用次数: 0
Functional status and its associated factors in Nigerian adults with serious mental illnesses 尼日利亚成人严重精神疾病患者的功能状态及其相关因素
Pub Date : 2019-01-09 DOI: 10.4314/ijmu.v13i2.3
S. Osasona, O. Akanni
Patients with serious mental illness may be less likely to achieve functional goals than the general population. Assessment of the functional impact of the illness is useful to determine severity of illness, evaluate remission, and achieve optimal treatment success. The aims of this study are to determine and compare the prevalence of low functional status among outpatients with major axis 1 psychiatric disorders, assess the risk factors for low functional status, and determine the proportion of the variance in low functional status explained by low self-esteem and non-adherence to medication. A descriptive cross-sectional study was conducted among 308 outpatients of the psychiatric unit of a tertiary hospital. The Global Assessment of Functions (GAF), Morisky Medication Adherence Scale (MMAS-8) and the Rosenberg’s Self-esteem Scale were used to collect data, which were analyzed using version 20 of SPSS. Level of statistical significance was set at 5% (P< 0.05). The overall prevalence of low functional status was 40.6%. Patients with schizophrenia had the highest prevalence of low functional status (53.4%). Educational attainment, employment status, self-esteem, medication adherence, and comorbidity had significant association with functional status. Poor medication adherence had the largest relative contribution (35.4%) to the variance in functional status, while self-esteem had an insignificant relative contribution of 3.4%. An appreciable proportion of the patients in this study had low functional status with more schizophrenic patients having impairment than patients with mood disorders. Poor medication adherence, among other variables, contributes significantly to low functional status. Physicians should give as much attention to functional recovery as they give to symptom resolution in the management of psychiatric patients. Keywords: Functional capacity; Psychiatric patient; Correlates; Benin-City
与一般人群相比,患有严重精神疾病的患者可能更不可能实现功能目标。评估疾病的功能影响有助于确定疾病的严重程度,评估缓解情况,并取得最佳治疗成功。本研究的目的是确定和比较主要1轴精神障碍门诊患者低功能状态的患病率,评估低功能状态的危险因素,并确定低自尊和药物依从性导致的低功能状态方差的比例。对某三级医院精神科门诊308例患者进行了描述性横断面研究。采用整体功能评估量表(GAF)、Morisky药物依从性量表(MMAS-8)和Rosenberg自尊量表收集数据,采用SPSS 20版进行分析。差异有统计学意义水平为5% (P< 0.05)。低功能状态的总患病率为40.6%。精神分裂症患者低功能状态的患病率最高(53.4%)。受教育程度、就业状况、自尊、药物依从性和合并症与功能状态显著相关。药物依从性差对功能状态方差的相对贡献最大(35.4%),而自尊对功能状态方差的相对贡献不显著(3.4%)。在这项研究中,相当比例的患者有低功能状态,精神分裂症患者比情绪障碍患者有更多的损害。在其他变量中,不良的药物依从性显著地导致了低功能状态。在精神病患者的管理中,医生应该给予功能恢复和症状解决同样多的关注。关键词:功能能力;精神病人;关联;贝宁城
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引用次数: 0
Prevalence of cleft lip and palate in Brazilian children 2011 - 2015 2011 - 2015年巴西儿童唇腭裂患病率
Pub Date : 2018-05-15 DOI: 10.4314/IJMU.V13I1.3
N. Andrade, T. Fernandes, E. Catão, Gustavo Correia Basto da Silva, L. Fernandes, Alidianne Fábia Cabral Cavalcanti, A. Cavalcanti
Cleft lip and cleft palate are birth defects of complex etiology. The aim of this study was to evaluate the occurrence of cleft lip and palate in Brazilian children. An ecological and descriptive study, based on data from the Live Birth Information System (SINASC / DATASUS) between years 2011 and 2015 in the cities of Joao Pessoa, Campina Grande, Patos, Cajazeiras, and Sousa (State of Paraiba) was developed. Information on the presence of congenital anomalies and cleft lip and palate, gender of neonate, birth-weight (<2.5kg and ≥2.5kg) and mother's age were collected. Data were tabulated with Microsoft Excel software and presented through descriptive statistics (absolute and percentage distributions). In the study period, there were 206367 cases of live birth, with 1916 cases of children with congenital anomalies of which 109 (5.7%) had cleft lip and palate, predominantly males (66%). Regarding birth-weight, 27.5% had <2.5kg. The majority of mothers aged 20-29 years (45.9%). The city of Campina Grande concentrated the highest number of cases (50.5%), with prevalence of 7.36 cases per ten thousand live births. The frequency of cleft lip and palate was 5.2 per 10000 live births. Male children with normal birth-weight are the most affected by cleft lip and palate. Key words : Epidemiology; Cleft Lip; Cleft Palate; Congenital Abnormalities
唇腭裂是一种病因复杂的先天性缺陷。本研究的目的是评估巴西儿童唇腭裂的发生情况。基于2011年至2015年在若昂佩索阿、坎皮纳格兰德、帕托斯、卡哈泽拉斯和索萨(帕拉伊巴州)等城市的活产信息系统(SINASC / DATASUS)的数据,开展了一项生态和描述性研究。收集先天性畸形和唇腭裂的存在、新生儿性别、出生体重(<2.5kg和≥2.5kg)和母亲年龄等信息。数据用Microsoft Excel软件制表,并通过描述性统计(绝对分布和百分比分布)呈现。研究期间共有活产患儿206367例,先天性畸形患儿1916例,其中唇腭裂109例(5.7%),以男性为主(66%)。出生体重<2.5kg的占27.5%。大多数母亲年龄在20-29岁(45.9%)。坎皮纳格兰德市集中的病例数最高(50.5%),患病率为每万例活产7.36例。唇腭裂的发生率为每万活产5.2例。出生体重正常的男孩最容易患唇腭裂。关键词:流行病学;唇裂;腭裂;先天性异常
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引用次数: 5
Editorial: Small group teaching and learning 编辑:小组教学
Pub Date : 2018-05-15 DOI: 10.4314/IJMU.V13I1.1
A. Agnihotri, Trevor Ngorosha
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引用次数: 2
期刊
Internet Journal of Medical Update - EJOURNAL
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