Pub Date : 2019-10-09DOI: 10.5152/ISTANBULJPHARM.2018.398141
F. Yilmaz
DOI: 10.5152/IstanbulJPharm.2018.398141 “Always Better Control” (ABC) and “Vital Essential Desirable” (VED) are widely used methods for controlling drug inventories. The purpose of this study is to contribute to the optimal level of drug storage for the hospital by evaluating the annual amounts spent on drugs with (ABC) and (VED). By this means, it is aimed to reduce inventory costs to an optimum level. In this study, drug consumption data of a private hospital operating in Istanbul for 2016 was used. Based on the annual unit consumption and the unit costs of 910 medicines, the total annual expenditure for each drug was calculated and drugs were ranked in increasing order according to this calculation. Drugs that accounted for 70% of the total drug expenditure were classified as Category A, 20% were classified as Category B, and 10% were classified as Category C. The (VED) analysis was conducted with three pharmacologists and drugs were classified according to their degree of vital importance as category “Vital (V)”, “Essential (E)” and “Desirable (D)”. Then, the data were combined with the (ABC-VED) matrix in three separate categories. According to a ABC analysis, 70.08% of this expenditure consists of 46 drugs (A), 19.88% of 92 drugs (B) and 10.04% of 772 drugs (C). According to the (VED) analysis, it has been determined that 265 drugs are in category “V”, 467 drugs in “E” and 178 drugs in “D”. According to the (ABC-VED) matrix, there are 298 drugs in the first category, 446 drugs in the second category and 163 drugs in the third category. Consequently, these analyzes will contribute to management especially in determining the safety stock levels of drugs that constitute a significant part of the total expenditure.
{"title":"The drug inventories evaluation of healthcare facilities using ABC and VED analyzes","authors":"F. Yilmaz","doi":"10.5152/ISTANBULJPHARM.2018.398141","DOIUrl":"https://doi.org/10.5152/ISTANBULJPHARM.2018.398141","url":null,"abstract":"DOI: 10.5152/IstanbulJPharm.2018.398141 “Always Better Control” (ABC) and “Vital Essential Desirable” (VED) are widely used methods for controlling drug inventories. The purpose of this study is to contribute to the optimal level of drug storage for the hospital by evaluating the annual amounts spent on drugs with (ABC) and (VED). By this means, it is aimed to reduce inventory costs to an optimum level. In this study, drug consumption data of a private hospital operating in Istanbul for 2016 was used. Based on the annual unit consumption and the unit costs of 910 medicines, the total annual expenditure for each drug was calculated and drugs were ranked in increasing order according to this calculation. Drugs that accounted for 70% of the total drug expenditure were classified as Category A, 20% were classified as Category B, and 10% were classified as Category C. The (VED) analysis was conducted with three pharmacologists and drugs were classified according to their degree of vital importance as category “Vital (V)”, “Essential (E)” and “Desirable (D)”. Then, the data were combined with the (ABC-VED) matrix in three separate categories. According to a ABC analysis, 70.08% of this expenditure consists of 46 drugs (A), 19.88% of 92 drugs (B) and 10.04% of 772 drugs (C). According to the (VED) analysis, it has been determined that 265 drugs are in category “V”, 467 drugs in “E” and 178 drugs in “D”. According to the (ABC-VED) matrix, there are 298 drugs in the first category, 446 drugs in the second category and 163 drugs in the third category. Consequently, these analyzes will contribute to management especially in determining the safety stock levels of drugs that constitute a significant part of the total expenditure.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87746281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-09DOI: 10.5152/ISTANBULJPHARM.2018.410411
B. Cetin, H. Şahin, A. Sarı
DOI: 10.5152/IstanbulJPharm.2018.410411 The genus Scorzonera (Asteraceae) has several species which are used as a vegetable and in folk medicine all around the world. A phytochemical study was carried out on petroleum ether fraction of methanol extract obtained from the roots of Scorzonera veratrifolia Fenzl (Bitlis / Turkey) to investigate the terpenoid composition of the plant. Column chromatography, preparative thin layer chromatography and gas chromatography (GC) were used for separation of the compounds. Their structures were determined by using GC-MS and NMR techniques. Seventeen triterpenoids (s-amyrin, s-amyrin acetate, s-amyrinone, germanicol, germanicol acetate, germanicone, α-amyrin, α-amyrin acetate, α-amyrinone, ψ – taraxasterol, ψ – taraxasterol acetate, taraxasterol, taraxasterol acetate, lupeol, lupeol acetate, lupenone, fern-7-en-3-one) and one sterol (s-sitosterol) were determined. The presence of these compounds has been shown for the first time in S. veratrifolia. α-amyrinone, s-amyrin, s-amyrinone, ψ – taraxasterol and ψ – taraxasterol acetate are new for the genus Scorzonera.
{"title":"Triterpenoids from Scorzonera veratrifolia Fenzl","authors":"B. Cetin, H. Şahin, A. Sarı","doi":"10.5152/ISTANBULJPHARM.2018.410411","DOIUrl":"https://doi.org/10.5152/ISTANBULJPHARM.2018.410411","url":null,"abstract":"DOI: 10.5152/IstanbulJPharm.2018.410411 The genus Scorzonera (Asteraceae) has several species which are used as a vegetable and in folk medicine all around the world. A phytochemical study was carried out on petroleum ether fraction of methanol extract obtained from the roots of Scorzonera veratrifolia Fenzl (Bitlis / Turkey) to investigate the terpenoid composition of the plant. Column chromatography, preparative thin layer chromatography and gas chromatography (GC) were used for separation of the compounds. Their structures were determined by using GC-MS and NMR techniques. Seventeen triterpenoids (s-amyrin, s-amyrin acetate, s-amyrinone, germanicol, germanicol acetate, germanicone, α-amyrin, α-amyrin acetate, α-amyrinone, ψ – taraxasterol, ψ – taraxasterol acetate, taraxasterol, taraxasterol acetate, lupeol, lupeol acetate, lupenone, fern-7-en-3-one) and one sterol (s-sitosterol) were determined. The presence of these compounds has been shown for the first time in S. veratrifolia. α-amyrinone, s-amyrin, s-amyrinone, ψ – taraxasterol and ψ – taraxasterol acetate are new for the genus Scorzonera.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89661196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-09DOI: 10.5152/ISTANBULJPHARM.2018.416835
C. Emir, N. Somer
DOI: 10.5152/IstanbulJPharm.2018.416835 In this study, a reversed-phase, high pressure liquid chromatography (RP-HPLC) method was applied in the quantitative analysis of lycorine in the aerial parts and bulbs of Galanthus alpinus Sosn. var. alpinus collected from Rize during the flowering and fruiting seasons. A simple method to extract lycorine from the plant specimens was performed, using pre-packed columns with diatomaceous earth (Extrelut®). The chromatographic separation was achieved employing an isocratic system with a mobile phase including trifluoroacetic acid-water-acetonitrile (0.01:95:5) measured at a flow rate of 1 mL/min using a diode array detector (DAD). The lycorine content in the bulbs during the flowering and fruiting seasons was detected as 0.01576 and 0.02351 %, respectively. Also, validation studies showed that the method was specific, accurate and precise.
{"title":"Quantitative analysis of lycorine in Galanthus alpinus Sosn. var. alpinus by HPLC-DAD","authors":"C. Emir, N. Somer","doi":"10.5152/ISTANBULJPHARM.2018.416835","DOIUrl":"https://doi.org/10.5152/ISTANBULJPHARM.2018.416835","url":null,"abstract":"DOI: 10.5152/IstanbulJPharm.2018.416835 In this study, a reversed-phase, high pressure liquid chromatography (RP-HPLC) method was applied in the quantitative analysis of lycorine in the aerial parts and bulbs of Galanthus alpinus Sosn. var. alpinus collected from Rize during the flowering and fruiting seasons. A simple method to extract lycorine from the plant specimens was performed, using pre-packed columns with diatomaceous earth (Extrelut®). The chromatographic separation was achieved employing an isocratic system with a mobile phase including trifluoroacetic acid-water-acetonitrile (0.01:95:5) measured at a flow rate of 1 mL/min using a diode array detector (DAD). The lycorine content in the bulbs during the flowering and fruiting seasons was detected as 0.01576 and 0.02351 %, respectively. Also, validation studies showed that the method was specific, accurate and precise.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77301669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-06DOI: 10.26650/istanbuljpharm.2019.19037
N. Ozhatay, S. Kultur, Bahar Gurdal
The ninth of the check-list series entitled “Check-list of additional taxa to the supplement flora of Turkey” includes 159 taxa based on 120 papers published the period between January 2017 and December 2018. These taxa have not been recorded in none of the 11 volumes of the Flora of Turkey nor in the eight previously published supplementary check-lists. With this paper the following are added to the Turkish flora: 117 taxa new to science and 42 taxa new records.
{"title":"Check-list of additional taxa to the supplement flora of Turkey IX","authors":"N. Ozhatay, S. Kultur, Bahar Gurdal","doi":"10.26650/istanbuljpharm.2019.19037","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2019.19037","url":null,"abstract":"The ninth of the check-list series entitled “Check-list of additional taxa to the supplement flora of Turkey” includes 159 taxa based on 120 papers published the period between January 2017 and December 2018. These taxa have not been recorded in none of the 11 volumes of the Flora of Turkey nor in the eight previously published supplementary check-lists. With this paper the following are added to the Turkish flora: 117 taxa new to science and 42 taxa new records.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89568269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-01DOI: 10.26650/istanbuljpharm.2019.19013
A. Karadaǧ, B. Demirci, Ömer Çeçen, F. Tosun
DOI : 10.26650/IstanbulJPharm.2019.19013 Chemical composition of volatile oils obtained from the roots, fruits and aerial parts of Glaucosciadium cordifolium (Boiss.) B.L. BurttP sabinene (10.1%), β-pinene (10.1%) and α-phellandrene (5.3%) in the essential oil of the fruits; hexadecane (12.2%), tetradecane (11.9%), octadecane (7.4%) in the essential oil obtained from the root, respectively. The in vitro microdilution method was used for the antimicrobial activity testing against Salmonella typhi ATCC 6539, Acinetobacter baumanii ATCC 19606, Bacillus cereus ATCC 14579, Staphylococcus aereus ATCC 6538, Listeria monocytogenes ATCC 19115, Helicobacter pylori ATCC 43504 and Mycobacterium avium ATCC 25291. The best antimicrobial activity of the volatile oils was against L. monocytogenes among the tested microorganisms. In addition, DPPH•-ABTS• scavenging activity was tested, none of the essential oils showed any significant antioxidant activity. Cite this article as : Karadag AE, Demirci B, Cecen O, Tosun F (2019). Chemical characterization of Glaucosciadium cordifolium (Boiss.) B. L. Burtt & P. H. Davis essential oils and their antimicrobial, and antioxidant activities. Istanbul J Pharm 49 (2): 77-80.
从Glaucosciadium cordifolium (Boiss.)的根，果实和空中部分获得的挥发油的化学成分B.L. BurttP果实精油中含有sabinene(10.1%)、β-蒎烯(10.1%)和α-茶树烯(5.3%);精油中十六烷(12.2%)、十四烷(11.9%)、十八烷(7.4%)含量较高。采用体外微量稀释法对伤寒沙门菌ATCC 6539、鲍曼不动杆菌ATCC 19606、蜡样芽孢杆菌ATCC 14579、绿葡萄球菌ATCC 6538、单核增生李斯特菌ATCC 19115、幽门螺杆菌ATCC 43504和鸟分枝杆菌ATCC 25291进行抑菌活性检测。其中挥发油对单核增生乳杆菌的抑菌活性最好。此外，对DPPH•-ABTS•清除活性进行了测试，结果表明所有精油均未表现出明显的抗氧化活性。本文引自:Karadag AE, Demirci B, Cecen O, Tosun F(2019)。青花草的化学性质B. L. Burtt & P. H. Davis精油及其抗菌和抗氧化活性。中华医学杂志，49(2):77-80。
{"title":"Chemical characterization of Glaucosciadium cordifolium (Boiss.) B. L. Burtt & P. H. Davis essential oils and their antimicrobial, and antioxidant activities","authors":"A. Karadaǧ, B. Demirci, Ömer Çeçen, F. Tosun","doi":"10.26650/istanbuljpharm.2019.19013","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2019.19013","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.19013 Chemical composition of volatile oils obtained from the roots, fruits and aerial parts of Glaucosciadium cordifolium (Boiss.) B.L. BurttP sabinene (10.1%), β-pinene (10.1%) and α-phellandrene (5.3%) in the essential oil of the fruits; hexadecane (12.2%), tetradecane (11.9%), octadecane (7.4%) in the essential oil obtained from the root, respectively. The in vitro microdilution method was used for the antimicrobial activity testing against Salmonella typhi ATCC 6539, Acinetobacter baumanii ATCC 19606, Bacillus cereus ATCC 14579, Staphylococcus aereus ATCC 6538, Listeria monocytogenes ATCC 19115, Helicobacter pylori ATCC 43504 and Mycobacterium avium ATCC 25291. The best antimicrobial activity of the volatile oils was against L. monocytogenes among the tested microorganisms. In addition, DPPH•-ABTS• scavenging activity was tested, none of the essential oils showed any significant antioxidant activity. Cite this article as : Karadag AE, Demirci B, Cecen O, Tosun F (2019). Chemical characterization of Glaucosciadium cordifolium (Boiss.) B. L. Burtt & P. H. Davis essential oils and their antimicrobial, and antioxidant activities. Istanbul J Pharm 49 (2): 77-80.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"160 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86792906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-01DOI: 10.26650/istanbuljpharm.2019.19017
I. Gazioğlu
DOI : 10.26650/IstanbulJPharm.2019.19017 Botanicals are widely used in cosmetic products due to their rich chemical compositions. There are numerous factors that affect the chemical profile of botanical content including growing, harvesting, drying and storage conditions. The reliability of a cosmetic product containing botanical ingredients is closely related to the quality control processes of the raw material. Aflatoxins can be transmitted to the botanicals at every stage of the production. The purpose of this study is to evaluate the ELISA method for the determination of aflatoxins in 20 personal care products containing plant extracts and/or oil. In this study, aflatoxin B1 (AFB1) was not detected in one of the samples containing chamomile extract, rose, shea & orange, and cocoa butter. Of the tested samples, 35% exceeded the legal limits of AFB1. The highest level was determined in sample containing coconut butter (15.13 ppb). These results show that raw materials of cosmetic products should be regularly and effectively controlled. Cite this article as : Gazioglu I (2019). Determination of aflatoxin B1 in cosmetics containing botanical ingredients by enzyme linked immunosorbent assay. Istanbul J Pharm 49 (2): 88-91.
{"title":"Determination of aflatoxin B1 in cosmetics containing botanical ingredients by enzyme linked immunosorbent assay","authors":"I. Gazioğlu","doi":"10.26650/istanbuljpharm.2019.19017","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2019.19017","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.19017 Botanicals are widely used in cosmetic products due to their rich chemical compositions. There are numerous factors that affect the chemical profile of botanical content including growing, harvesting, drying and storage conditions. The reliability of a cosmetic product containing botanical ingredients is closely related to the quality control processes of the raw material. Aflatoxins can be transmitted to the botanicals at every stage of the production. The purpose of this study is to evaluate the ELISA method for the determination of aflatoxins in 20 personal care products containing plant extracts and/or oil. In this study, aflatoxin B1 (AFB1) was not detected in one of the samples containing chamomile extract, rose, shea & orange, and cocoa butter. Of the tested samples, 35% exceeded the legal limits of AFB1. The highest level was determined in sample containing coconut butter (15.13 ppb). These results show that raw materials of cosmetic products should be regularly and effectively controlled. Cite this article as : Gazioglu I (2019). Determination of aflatoxin B1 in cosmetics containing botanical ingredients by enzyme linked immunosorbent assay. Istanbul J Pharm 49 (2): 88-91.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77541054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-01DOI: 10.26650/istanbuljpharm.2019.18008
A. Abubakar, M. Haque
DOI : 10.26650/IstanbulJPharm.2019.18008 Medicinal plants have been widely used in folklore medicine in the treatment of various diseases such as mental and neurological disorders. Mental disorders like anxiety and depression are very common among Nigerian populace. The purpose of this review was to access and evaluate several articles published on the anxiolytic and sedative properties of medicinal plants in Nigeria and to find out the gaps left for further research and drug development. Eighty-two publications available among Nigerian Universities and Research Institutes between 2008 and 2018 were selected. Seven electronic databases such as Nigerian Plant Database, HerbMed, AGRICOLA, MedlinePlus, PubMed, ScienceDirect, and Springer-Link were thoroughly explored from which 226 relevant articles were obtained using Google Scholar, Hotbot and FreeFullPdf as search engines. A number of studies conducted to test for the anxiolytic and sedative activity of medicinal plants in Nigeria were included. Articles published between 2008 and 2018 were selected. The studies were conducted in Nigeria. Research carried out before 2008 was not selected. All publications with authorship outside Nigeria were excluded. Several medicinal plants on which experiments were conducted were reported to have anxiolytic and or sedative properties in Nigeria. Several medicinal plants have shown promise as anxiolytic and sedative agents in laboratory animals’ studies. The majority of these plants were used traditionally in the past to treat anxiety in Nigeria. Further research on the efficacy and safety of these medicinal plants could yield a more cost effective and perhaps safer alternative in the treatment of anxiety among Nigerians. Cite this article as : Abubakar AR, Haque M (2019). Medicinal plants with reported anxiolytic and sedative activities in Nigeria: A systematic review. Istanbul J Pharm 49 (2): 92-104.
{"title":"Medicinal plants with reported anxiolytic and sedative activities in Nigeria: A systematic review","authors":"A. Abubakar, M. Haque","doi":"10.26650/istanbuljpharm.2019.18008","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2019.18008","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.18008 Medicinal plants have been widely used in folklore medicine in the treatment of various diseases such as mental and neurological disorders. Mental disorders like anxiety and depression are very common among Nigerian populace. The purpose of this review was to access and evaluate several articles published on the anxiolytic and sedative properties of medicinal plants in Nigeria and to find out the gaps left for further research and drug development. Eighty-two publications available among Nigerian Universities and Research Institutes between 2008 and 2018 were selected. Seven electronic databases such as Nigerian Plant Database, HerbMed, AGRICOLA, MedlinePlus, PubMed, ScienceDirect, and Springer-Link were thoroughly explored from which 226 relevant articles were obtained using Google Scholar, Hotbot and FreeFullPdf as search engines. A number of studies conducted to test for the anxiolytic and sedative activity of medicinal plants in Nigeria were included. Articles published between 2008 and 2018 were selected. The studies were conducted in Nigeria. Research carried out before 2008 was not selected. All publications with authorship outside Nigeria were excluded. Several medicinal plants on which experiments were conducted were reported to have anxiolytic and or sedative properties in Nigeria. Several medicinal plants have shown promise as anxiolytic and sedative agents in laboratory animals’ studies. The majority of these plants were used traditionally in the past to treat anxiety in Nigeria. Further research on the efficacy and safety of these medicinal plants could yield a more cost effective and perhaps safer alternative in the treatment of anxiety among Nigerians. Cite this article as : Abubakar AR, Haque M (2019). Medicinal plants with reported anxiolytic and sedative activities in Nigeria: A systematic review. Istanbul J Pharm 49 (2): 92-104.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80250666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-01DOI: 10.26650/istanbuljpharm.2019.18001
Serpil Uğraş, Sultan Ülger, P. Rasgele
DOI : 10.26650/IstanbulJPharm.2019.18001 The aim of this study is to evaluate the antimicrobial, antioxidant, and antigenotoxic activity of extracts obtained from Diplotaenia cachrydifolia Boiss, which is traditionally used for food and medical treatment by the local people of Hakkâri Province (Turkey). As a result of this study, the extracts of D. cachrydifolia exhibited a broad antimicrobial spectrum and high antimicrobial activity. It was also observed that the extracts had a high antioxidant activity. The DPPH IC50 values of the extracts were 2.5234 µg/mL, 6.0075 µg/mL, and 29.1974 µg/mL for ethanol, acetone, and hexane, respectively. The highest phenol content was found to be 55.36±0.035 μg/mL for ethanol. Furthermore, the ethanol extract was found to have a protective effect against mitomycin C-induced genotoxicity. D. cachrydifolia has a high biological activity; therefore, it is anticipated that future pharmacological studies will shed more light on this plant. Cite this article as : Ugras S, Ulger S, Goc Rasgele P (2019). Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant. Istanbul J Pharm 49 (2): 45-52.
{"title":"Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant","authors":"Serpil Uğraş, Sultan Ülger, P. Rasgele","doi":"10.26650/istanbuljpharm.2019.18001","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2019.18001","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.18001 The aim of this study is to evaluate the antimicrobial, antioxidant, and antigenotoxic activity of extracts obtained from Diplotaenia cachrydifolia Boiss, which is traditionally used for food and medical treatment by the local people of Hakkâri Province (Turkey). As a result of this study, the extracts of D. cachrydifolia exhibited a broad antimicrobial spectrum and high antimicrobial activity. It was also observed that the extracts had a high antioxidant activity. The DPPH IC50 values of the extracts were 2.5234 µg/mL, 6.0075 µg/mL, and 29.1974 µg/mL for ethanol, acetone, and hexane, respectively. The highest phenol content was found to be 55.36±0.035 μg/mL for ethanol. Furthermore, the ethanol extract was found to have a protective effect against mitomycin C-induced genotoxicity. D. cachrydifolia has a high biological activity; therefore, it is anticipated that future pharmacological studies will shed more light on this plant. Cite this article as : Ugras S, Ulger S, Goc Rasgele P (2019). Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant. Istanbul J Pharm 49 (2): 45-52.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80658637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-01DOI: 10.26650/istanbuljpharm.2019.18010
S. Ilikay, E. Coskunpinar, Ozlem Kurnaz-Gomleksiz, Z. Bugra, A. Eronat, O. Ozturk, H. Yılmaz-Aydoğan
DOI : 10.26650/IstanbulJPharm.2019.18010 Caveolin-1 (CAV-1) plays a crucial role in endothelial-nitric oxide synthase (eNOS) enzymatic activity. Therefore, CAV-1 and eNOS interactions have a significant impact on endothelial dysfunction, cholesterol levels, and atherosclerosis. We investigated the critical variations in NOS3 and CAV1 genes in this case–control study to determine the relations between the coronary heart disease (CHD) risk factors. The NOS3-rs1799983, CAV-1 rs3840634, and rs3807990 variations were analyzed in 76 CHD patients and 91 controls using the polymerase chain reaction. Mean serum Total-cholesterol levels were significantly higher in CHD patients with the CAV-1 rs3807990-T allele than in patients with CC genotype (p=0.017). There was a statistically significant correlation between the rs3807990-T allele and hypercholesterolemia in the CHD group (p=0.008). The multivariate analysis confirmed that the CAV-1 rs3807990-T allele (p=0.011) is a risk factor for hypercholesterolemia. Moreover, the serum HDL-Cholesterol level was detected to be higher in patients carrying both CAV1-rs3807990-T and NOS3-rs1799983-T alleles than those with the CAV-1 rs3807990-CC/NOS3-rs1799983-GG genotype subgroup (p=0.013). These results suggested that the genetic variations of CAV-1 rs3807990 and NOS3-rs1799983 may contribute to the increased hypercholesterolemia risk and thus on the development of CHD. Cite this article as : Ilikay S, Coskunpinar E, Kurnaz-Gomleksiz O, Bugra Z, Eronat AP, Ozturk O, Yilmaz-Aydogan H (2019). Effects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart disease. Istanbul J Pharm 49 (2): 53-60.
cavo -1 (CAV-1)在内皮-一氧化氮合酶(eNOS)酶活性中起着至关重要的作用。因此，CAV-1和eNOS相互作用对内皮功能障碍、胆固醇水平和动脉粥样硬化有显著影响。在本病例对照研究中，我们研究了NOS3和CAV1基因的关键变异，以确定冠心病(CHD)危险因素之间的关系。应用聚合酶链反应分析76例冠心病患者和91例对照的NOS3-rs1799983、CAV-1 rs3840634和rs3807990基因变异。CAV-1 rs3807990-T等位基因的冠心病患者的平均血清总胆固醇水平显著高于CC基因型患者(p=0.017)。rs3807990-T等位基因与冠心病患者高胆固醇血症的相关性有统计学意义(p=0.008)。多因素分析证实CAV-1 rs3807990-T等位基因(p=0.011)是高胆固醇血症的危险因素。同时携带CAV1-rs3807990-T和NOS3-rs1799983-T等位基因的患者血清hdl -胆固醇水平高于携带cav - rs3807990-CC/NOS3-rs1799983-GG基因型亚组的患者(p=0.013)。这些结果提示CAV-1 rs3807990和NOS3-rs1799983基因变异可能与高胆固醇血症风险增加有关，从而导致冠心病的发生。本文引自:Ilikay S, Coskunpinar E, Kurnaz-Gomleksiz O, Bugra Z, Eronat AP, Ozturk O, Yilmaz-Aydogan H(2019)。NOS3和CAV1基因共同变异对冠心病患者高胆固醇血症谱的影响中华医学杂志，49(2):53-60。
{"title":"Effects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart disease","authors":"S. Ilikay, E. Coskunpinar, Ozlem Kurnaz-Gomleksiz, Z. Bugra, A. Eronat, O. Ozturk, H. Yılmaz-Aydoğan","doi":"10.26650/istanbuljpharm.2019.18010","DOIUrl":"https://doi.org/10.26650/istanbuljpharm.2019.18010","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.18010 Caveolin-1 (CAV-1) plays a crucial role in endothelial-nitric oxide synthase (eNOS) enzymatic activity. Therefore, CAV-1 and eNOS interactions have a significant impact on endothelial dysfunction, cholesterol levels, and atherosclerosis. We investigated the critical variations in NOS3 and CAV1 genes in this case–control study to determine the relations between the coronary heart disease (CHD) risk factors. The NOS3-rs1799983, CAV-1 rs3840634, and rs3807990 variations were analyzed in 76 CHD patients and 91 controls using the polymerase chain reaction. Mean serum Total-cholesterol levels were significantly higher in CHD patients with the CAV-1 rs3807990-T allele than in patients with CC genotype (p=0.017). There was a statistically significant correlation between the rs3807990-T allele and hypercholesterolemia in the CHD group (p=0.008). The multivariate analysis confirmed that the CAV-1 rs3807990-T allele (p=0.011) is a risk factor for hypercholesterolemia. Moreover, the serum HDL-Cholesterol level was detected to be higher in patients carrying both CAV1-rs3807990-T and NOS3-rs1799983-T alleles than those with the CAV-1 rs3807990-CC/NOS3-rs1799983-GG genotype subgroup (p=0.013). These results suggested that the genetic variations of CAV-1 rs3807990 and NOS3-rs1799983 may contribute to the increased hypercholesterolemia risk and thus on the development of CHD. Cite this article as : Ilikay S, Coskunpinar E, Kurnaz-Gomleksiz O, Bugra Z, Eronat AP, Ozturk O, Yilmaz-Aydogan H (2019). Effects of common variations of NOS3 and CAV1 genes on hypercholesterolemic profile in coronary heart disease. Istanbul J Pharm 49 (2): 53-60.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84944864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-01DOI: 10.26650/ISTANBULJPHARM.2019.19011
Leyla Alaca, Fulya Aydinli Kulak
DOI : 10.26650/IstanbulJPharm.2019.19011 This study was conducted to determine the ethical awareness of pharmacy students. Additionally, it intends to find the similarities and differences between ethical orientations of the pharmacy students having done the course “Pharmacy Deontology” or not. Moreover, the views and evaluations of the students who have completed the course are determined. Two hundred pharmacy students from Istanbul University Faculty of Pharmacy participated in the research. The research data was collected through questionnaires prepared by the researchers based on Deontology Charter by the Turkish Pharmacists’ Association and the Pharmacies and Pharmacists Law no. 6197 and analyzed via t-test. The general results reflect a great deal of ethical awareness except the issues such as, providing prescription medicine and non-medical health products, promotional activities and use of advertisements. Moreover, there is a statistical significant difference between the two groups’ of ethical orientations (participants having completed the course or not). As an overall evaluation, the pharmacy deontology course seems to add value for pharmacicst candidates to make ethical decisions. Cite this article as : Alaca L, Aydinli Kulak F (2019). Ethics in pharmacy education: a research on pharmacy students’ ethical awareness and views. Istanbul J Pharm 49 (2): 70-76.
{"title":"Ethics in pharmacy education: a research on pharmacy students’ ethical awareness and views","authors":"Leyla Alaca, Fulya Aydinli Kulak","doi":"10.26650/ISTANBULJPHARM.2019.19011","DOIUrl":"https://doi.org/10.26650/ISTANBULJPHARM.2019.19011","url":null,"abstract":"DOI : 10.26650/IstanbulJPharm.2019.19011 This study was conducted to determine the ethical awareness of pharmacy students. Additionally, it intends to find the similarities and differences between ethical orientations of the pharmacy students having done the course “Pharmacy Deontology” or not. Moreover, the views and evaluations of the students who have completed the course are determined. Two hundred pharmacy students from Istanbul University Faculty of Pharmacy participated in the research. The research data was collected through questionnaires prepared by the researchers based on Deontology Charter by the Turkish Pharmacists’ Association and the Pharmacies and Pharmacists Law no. 6197 and analyzed via t-test. The general results reflect a great deal of ethical awareness except the issues such as, providing prescription medicine and non-medical health products, promotional activities and use of advertisements. Moreover, there is a statistical significant difference between the two groups’ of ethical orientations (participants having completed the course or not). As an overall evaluation, the pharmacy deontology course seems to add value for pharmacicst candidates to make ethical decisions. Cite this article as : Alaca L, Aydinli Kulak F (2019). Ethics in pharmacy education: a research on pharmacy students’ ethical awareness and views. Istanbul J Pharm 49 (2): 70-76.","PeriodicalId":14484,"journal":{"name":"İstanbul Journal of Pharmacy","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89699129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：