Pub Date : 2023-05-15DOI: 10.18231/j.ijirm.2023.005
Swapnil R. Jain, Ashish Diwan, Ravendra Singh, A. Julka
: The Coronavirus disease 2019 is a disease caused by the etiological agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was a newly identified β-coronavirus that had spread rapidly around the world, resulting in a very high number of infections and deaths, threatening public security, and placing a heavy burden on global healthcare systems and economy. The present study was done to study antibody response in COVID-19 infection.: The study was carried out in the Department of Respiratory Medicine, R.D. Gardi Medical College, Ujjain, India after approval by ethics committee. The post COVID-19 cases attending respiratory medicine OPD were included in the study.: The present study was conducted in 122 patients. The mean age of the patients was 51.20±14.21 years, median age was 54.5 years, the minimum age was 14 years and the maximum age was 80 years, the most number of COVID-19 infection cases was in the elderly age group of more than 50 years. The severity of disease was seen in those above 50 years of age (57.3%) with p>0.05. Among the severe cases mean age of the cases was 49±17 years, in moderate cases mean age 52±14 and among mild group of cases mean age was 51±15 years.In the present study there were 73.8% males and females were 26.2% Among COVID-19 cases who reported in the OPD the maximum that is 86 (>70%) patients had moderately severe disease, while severe cases were only about 14 %. Mild cases were 15.6%.In the present study RT-PCR were negative in 36(29.5%) as against 86 (70.5%) were confirmed cases of COVID-19 and among positive cases 40 % cases became negative between 6-10 daysAmong severe disease cases mean SARS COV2 antibody 650.06±240.47 was significantly higher as compare to moderate cases 461.49±331.41 and mild cases 404.11±240.47.: India has the world’s largest vaccination program. COVID-19 antibodies estimation are important tests carried out to determine the response of the body against COVID-19 infection.Our results show a significant association between SARS COV2 antibody and the severity of disease.
{"title":"A study of antibody response to Covid-19 infection","authors":"Swapnil R. Jain, Ashish Diwan, Ravendra Singh, A. Julka","doi":"10.18231/j.ijirm.2023.005","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.005","url":null,"abstract":": The Coronavirus disease 2019 is a disease caused by the etiological agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was a newly identified β-coronavirus that had spread rapidly around the world, resulting in a very high number of infections and deaths, threatening public security, and placing a heavy burden on global healthcare systems and economy. The present study was done to study antibody response in COVID-19 infection.: The study was carried out in the Department of Respiratory Medicine, R.D. Gardi Medical College, Ujjain, India after approval by ethics committee. The post COVID-19 cases attending respiratory medicine OPD were included in the study.: The present study was conducted in 122 patients. The mean age of the patients was 51.20±14.21 years, median age was 54.5 years, the minimum age was 14 years and the maximum age was 80 years, the most number of COVID-19 infection cases was in the elderly age group of more than 50 years. The severity of disease was seen in those above 50 years of age (57.3%) with p>0.05. Among the severe cases mean age of the cases was 49±17 years, in moderate cases mean age 52±14 and among mild group of cases mean age was 51±15 years.In the present study there were 73.8% males and females were 26.2% Among COVID-19 cases who reported in the OPD the maximum that is 86 (>70%) patients had moderately severe disease, while severe cases were only about 14 %. Mild cases were 15.6%.In the present study RT-PCR were negative in 36(29.5%) as against 86 (70.5%) were confirmed cases of COVID-19 and among positive cases 40 % cases became negative between 6-10 daysAmong severe disease cases mean SARS COV2 antibody 650.06±240.47 was significantly higher as compare to moderate cases 461.49±331.41 and mild cases 404.11±240.47.: India has the world’s largest vaccination program. COVID-19 antibodies estimation are important tests carried out to determine the response of the body against COVID-19 infection.Our results show a significant association between SARS COV2 antibody and the severity of disease.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84910788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-15DOI: 10.18231/j.ijirm.2023.001
S. Kant, A. Pandey, A. Verma
{"title":"Rise of the H3N2 influenza virus in India: ways to deal with it","authors":"S. Kant, A. Pandey, A. Verma","doi":"10.18231/j.ijirm.2023.001","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.001","url":null,"abstract":"","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86534391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-15DOI: 10.18231/j.ijirm.2023.009
M. Kumar, Kavneet Anand, S. Bhoi
{"title":"Mesenchymal stem cell-derived multivesicular bodies: Is it innovative novel cell-based therapeutic adjunct for trauma hemorrhagic shock patients?","authors":"M. Kumar, Kavneet Anand, S. Bhoi","doi":"10.18231/j.ijirm.2023.009","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.009","url":null,"abstract":"","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74865189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-15DOI: 10.18231/j.ijirm.2023.004
Anjali Singh, S. Kant, N. Verma, A. Verma, A. Tripathi
Nutrition has been recognized as an important factor in health and disease for many years. However, it is only recently that the importance of nutrition in patients with chronic lung disease has come into focus. There has been a profound link between nutrition and lung health. Malnutrition could lead to poor lung development. Various diet such as Mediterranean diet, prudent diet, etc. have reported their protective effect against respiratory diseases while westernized dietary patterns and fast-food intake could cause poor lung health. Fruits and vegetables constituting various vitamins and minerals provide antioxidant shield to the lungs. Apart from this, one leading nutrient omega-3 fatty acids primarily found in sea food is emerging to have beneficial role for the lung’s wellbeing. Its anti-inflammatory property helps to combat respiratory diseases such as asthma, cystic fibrosis and COPD. Even in the chronic conditions such as lung cancer it works as an important constituent of nutritional therapy. It also impairs immune responses against various infections and strengthen lungs. To our surprise it has also proven positive effects over smoking cessation also. However, more research is certainly needed to identify the chief role of nutrients involved in managing respiratory diseases and their implications in practicality.
{"title":"Omega 3 fatty acid: A boon for pulmonary health","authors":"Anjali Singh, S. Kant, N. Verma, A. Verma, A. Tripathi","doi":"10.18231/j.ijirm.2023.004","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.004","url":null,"abstract":"Nutrition has been recognized as an important factor in health and disease for many years. However, it is only recently that the importance of nutrition in patients with chronic lung disease has come into focus. There has been a profound link between nutrition and lung health. Malnutrition could lead to poor lung development. Various diet such as Mediterranean diet, prudent diet, etc. have reported their protective effect against respiratory diseases while westernized dietary patterns and fast-food intake could cause poor lung health. Fruits and vegetables constituting various vitamins and minerals provide antioxidant shield to the lungs. Apart from this, one leading nutrient omega-3 fatty acids primarily found in sea food is emerging to have beneficial role for the lung’s wellbeing. Its anti-inflammatory property helps to combat respiratory diseases such as asthma, cystic fibrosis and COPD. Even in the chronic conditions such as lung cancer it works as an important constituent of nutritional therapy. It also impairs immune responses against various infections and strengthen lungs. To our surprise it has also proven positive effects over smoking cessation also. However, more research is certainly needed to identify the chief role of nutrients involved in managing respiratory diseases and their implications in practicality.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87313684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-15DOI: 10.18231/j.ijirm.2023.008
Ankit Kumar, L. Devi, Y. Verma, Parul Sharma, A. Ahmad, Shubham Chandra
: Allergic Bronchopulmonary Aspergillosis (ABPA) is an allergic hypersensitivity reaction to the ubiquitous fungus Aspergillus that can cause inflammation and damage to the respiratory system. This condition predominantly occurs in individuals with long-standing airway disease, such as bronchial asthma or cystic fibrosis. While Acid-fast bacilli Mycobacterium tuberculosis causes tuberculosis (TB). ABPA and TB can coexist in the same patient. The coexistence of these two conditions can make the diagnosis and treatment more challenging. This is because some of the symptoms of ABPA, such as cough and wheezing, can be similar to those of TB, and both conditions can cause lung damage. A 21-year young male was admitted with a six-month history of low-grade fever, cough with expectoration, atypical chest pain, and progressive breathlessness. On examination, the patient had bilateral diffuse rhonchi with coarse crepitation, and his chest X-ray showed bilateral heterogeneous opacities with cavities in the left upper and middle zone. Further evaluation revealed a total serum IgE of 3074 IU/L (Normal <100) and elevated levels of Aspergillus fumigatus-specific IgE and IgG. A high-resolution CT of the thorax revealed bilateral upper lobes with tree-in-bud opacities and centrilobular nodules, leading to a diagnosis of ABPA. A sputum sample was sent for an AFB smear, which was positive.Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity reaction to Aspergillus fumigatus that most commonly affects people who have bronchial asthma or cystic fibrosis. However, diagnosis can be challenging as patients may not respond to standard treatment, and the symptoms can overlap with those of other respiratory diseases. Therefore, clinicians need to maintain a high index of suspicion for ABPA in at-risk patients and consider appropriate screening tests.This case highlights the rare co-existence of active pulmonary TB and ABPA, which can make diagnosis and treatment challenging. However, with appropriate management, including anti-tubercular treatment and corticosteroid therapy, the patient showed marked improvement in his condition. Clinicians should consider the possibility of multiple comorbidities in patients presenting with respiratory symptoms, and appropriate evaluation and management should be undertaken to achieve optimal outcomes.
{"title":"Unusual coexistence: Allergic bronchopulmonary aspergillosis and pulmonary tuberculosis- A rare case report","authors":"Ankit Kumar, L. Devi, Y. Verma, Parul Sharma, A. Ahmad, Shubham Chandra","doi":"10.18231/j.ijirm.2023.008","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.008","url":null,"abstract":": Allergic Bronchopulmonary Aspergillosis (ABPA) is an allergic hypersensitivity reaction to the ubiquitous fungus Aspergillus that can cause inflammation and damage to the respiratory system. This condition predominantly occurs in individuals with long-standing airway disease, such as bronchial asthma or cystic fibrosis. While Acid-fast bacilli Mycobacterium tuberculosis causes tuberculosis (TB). ABPA and TB can coexist in the same patient. The coexistence of these two conditions can make the diagnosis and treatment more challenging. This is because some of the symptoms of ABPA, such as cough and wheezing, can be similar to those of TB, and both conditions can cause lung damage. A 21-year young male was admitted with a six-month history of low-grade fever, cough with expectoration, atypical chest pain, and progressive breathlessness. On examination, the patient had bilateral diffuse rhonchi with coarse crepitation, and his chest X-ray showed bilateral heterogeneous opacities with cavities in the left upper and middle zone. Further evaluation revealed a total serum IgE of 3074 IU/L (Normal <100) and elevated levels of Aspergillus fumigatus-specific IgE and IgG. A high-resolution CT of the thorax revealed bilateral upper lobes with tree-in-bud opacities and centrilobular nodules, leading to a diagnosis of ABPA. A sputum sample was sent for an AFB smear, which was positive.Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity reaction to Aspergillus fumigatus that most commonly affects people who have bronchial asthma or cystic fibrosis. However, diagnosis can be challenging as patients may not respond to standard treatment, and the symptoms can overlap with those of other respiratory diseases. Therefore, clinicians need to maintain a high index of suspicion for ABPA in at-risk patients and consider appropriate screening tests.This case highlights the rare co-existence of active pulmonary TB and ABPA, which can make diagnosis and treatment challenging. However, with appropriate management, including anti-tubercular treatment and corticosteroid therapy, the patient showed marked improvement in his condition. Clinicians should consider the possibility of multiple comorbidities in patients presenting with respiratory symptoms, and appropriate evaluation and management should be undertaken to achieve optimal outcomes.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90056617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-15DOI: 10.18231/j.ijirm.2023.006
M. Manohar, R. Anuja
Atopic symptoms are a commonly encountered presentation the pulmonology, dermatology and medical outpatient visits. Identification and avoidance of the precipitating factors is important in the management of these patients. Clinical history usually doesn’t give a complete picture of the spectrum of allergen sensitivity. Skin prick Test is described as a safe technique in identifying some obscure precipitating factors that might be worsening the clinical scenario.This is a 6 month cross sectional study conducted in a research institute in central Kerala among 31 chronic urticaria patients during May to October 2022. Skin prick testing with 30 common food allergens was done.Among the 31 subjects studied 26 (83.87 %) had allergy to foods (90 % among males and 80 % among females). Dal Urud (35.35 %) was the found as the most frequent food allergen, followed by pea (25.8 %), fish, rice and wheat (22.7%). Dal Arhar, Milk and fennel seeds were found to be the least common food allergens.Apart from minor itching and redness, none of the subjects developed significant reactions following the test.This study underlines the importance and safety of skin prick testing in patients with chronic uricaria. In this study it was found that more commonly used foods in Kerala like rice, dal urud were more sensitive.
{"title":"Food allergen sensitivity in atopy","authors":"M. Manohar, R. Anuja","doi":"10.18231/j.ijirm.2023.006","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.006","url":null,"abstract":"Atopic symptoms are a commonly encountered presentation the pulmonology, dermatology and medical outpatient visits. Identification and avoidance of the precipitating factors is important in the management of these patients. Clinical history usually doesn’t give a complete picture of the spectrum of allergen sensitivity. Skin prick Test is described as a safe technique in identifying some obscure precipitating factors that might be worsening the clinical scenario.This is a 6 month cross sectional study conducted in a research institute in central Kerala among 31 chronic urticaria patients during May to October 2022. Skin prick testing with 30 common food allergens was done.Among the 31 subjects studied 26 (83.87 %) had allergy to foods (90 % among males and 80 % among females). Dal Urud (35.35 %) was the found as the most frequent food allergen, followed by pea (25.8 %), fish, rice and wheat (22.7%). Dal Arhar, Milk and fennel seeds were found to be the least common food allergens.Apart from minor itching and redness, none of the subjects developed significant reactions following the test.This study underlines the importance and safety of skin prick testing in patients with chronic uricaria. In this study it was found that more commonly used foods in Kerala like rice, dal urud were more sensitive.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"305 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77112394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-15DOI: 10.18231/j.ijirm.2023.007
V. Babu, P. Upadhya, S. C., Naren Chandra Vijayarengan, P. Toi
Organizing pneumonia is an interstitial lung disease that affects the distal bronchiole, respiratory bronchiole, alveolar ducts, and walls. To diagnose cryptogenic organising pneumonia, other aetiologies, such as inflammatory infections, connective tissue disease, drug responses, pulmonary infarction, and organ transplantation need to be ruled out. Radiological and histological progress in this disease will help to understand the disease in a better way. Early diagnosis of organizing pneumonia is important because of a good prognosis if it is treated earlier. But atypical clinical and radiological presentation will lead to difficulty in diagnosis and delay in treatment. Here we report two atypical presentations of organizing pneumonia cases to highlight the importance of upfront aggressive multimodality diagnostic approaches to rule out rare causes of cavitating lesions.
{"title":"Cryptogenic organising pneumonia- Atypical presentation","authors":"V. Babu, P. Upadhya, S. C., Naren Chandra Vijayarengan, P. Toi","doi":"10.18231/j.ijirm.2023.007","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.007","url":null,"abstract":"Organizing pneumonia is an interstitial lung disease that affects the distal bronchiole, respiratory bronchiole, alveolar ducts, and walls. To diagnose cryptogenic organising pneumonia, other aetiologies, such as inflammatory infections, connective tissue disease, drug responses, pulmonary infarction, and organ transplantation need to be ruled out. Radiological and histological progress in this disease will help to understand the disease in a better way. Early diagnosis of organizing pneumonia is important because of a good prognosis if it is treated earlier. But atypical clinical and radiological presentation will lead to difficulty in diagnosis and delay in treatment. Here we report two atypical presentations of organizing pneumonia cases to highlight the importance of upfront aggressive multimodality diagnostic approaches to rule out rare causes of cavitating lesions.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72983483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-15DOI: 10.18231/j.ijirm.2023.002
S. Yadav, G. Rawal
{"title":"Destroyed lung syndrome","authors":"S. Yadav, G. Rawal","doi":"10.18231/j.ijirm.2023.002","DOIUrl":"https://doi.org/10.18231/j.ijirm.2023.002","url":null,"abstract":"","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87069386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-15DOI: 10.18231/j.ijirm.2022.039
M. Devraj, Chaitanya Kappagantu, Sushma Dugad, Ravidra Shinde, K. Shah
T-lymphoblastic lymphoma (T-LBL) is most commonly found in younger age group and rare. It is most aggressive form ofnon-Hodgkin’s lymphoma. T-lymphoblastic lymphoma (T-LBL) response rate to chemotherapy is very good although relapse is common with poor survival rates.A 25 years old female presented to emergency department of a tertiary care centre with dyspnoea and chest tube in left Hemothorax in situ. She had earlier history of pulmonary tuberculosis 3 years back and took anti tubercular treatment for 6 months. On general examination we found left supraclavicular lymphadenopathy of size 2 × 1.5cm and grade 2 clubbing.The pleural fluid was sent for analysis. It was reported as exudative pleural effusion with low ADA and negative for malignant cells. Lymph node biopsy was sent for histopathological examination which was reported as T Lymphoblastic lymphoma. NHL is a diverse category of cancers that originate from B or T cells at different stages of maturation. In relation to our case; earlier history of tuberculosis, pus from lymph node could mislead to infective aetiology; as lymph node necrosis is commonly found in Hodgkin’s disease. This fact reiterates the fact that through clinical examination and history leads to proper diagnosis and management of the patient and can save time of the patients.
{"title":"An aberrant presentation of non-hodgkin’s lymphoma as pus: A curious journey","authors":"M. Devraj, Chaitanya Kappagantu, Sushma Dugad, Ravidra Shinde, K. Shah","doi":"10.18231/j.ijirm.2022.039","DOIUrl":"https://doi.org/10.18231/j.ijirm.2022.039","url":null,"abstract":"T-lymphoblastic lymphoma (T-LBL) is most commonly found in younger age group and rare. It is most aggressive form ofnon-Hodgkin’s lymphoma. T-lymphoblastic lymphoma (T-LBL) response rate to chemotherapy is very good although relapse is common with poor survival rates.A 25 years old female presented to emergency department of a tertiary care centre with dyspnoea and chest tube in left Hemothorax in situ. She had earlier history of pulmonary tuberculosis 3 years back and took anti tubercular treatment for 6 months. On general examination we found left supraclavicular lymphadenopathy of size 2 × 1.5cm and grade 2 clubbing.The pleural fluid was sent for analysis. It was reported as exudative pleural effusion with low ADA and negative for malignant cells. Lymph node biopsy was sent for histopathological examination which was reported as T Lymphoblastic lymphoma. NHL is a diverse category of cancers that originate from B or T cells at different stages of maturation. In relation to our case; earlier history of tuberculosis, pus from lymph node could mislead to infective aetiology; as lymph node necrosis is commonly found in Hodgkin’s disease. This fact reiterates the fact that through clinical examination and history leads to proper diagnosis and management of the patient and can save time of the patients.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84812052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-15DOI: 10.18231/j.ijirm.2022.041
Sudershana Patil
The case series of three patients is an attempt to report the importance of early use of Itolizumab in the treatment of non-COVID 19 acute respiratory distress syndrome (ARDS) admitted to the intensive care unit. Monitoring total counts, oxygen requirements, respiratory capacity, and sepsis biomarkers along with strong clinical history and presentation helped in determining the stage of sepsis, allowing the treating physician to prescribe Itolizumab as the treatment of choice when septic shock and complications such as multiple (greater than or equal to 2) organ system failure MOSF has not set in. The efficacy of Itolizumab in this clinical setting was preventative as it blocked the CD6+ receptors, preventing activation of inflammatory reaction and release of large amounts of pro-inflammatory mediators including IL-1, IL-6, TNF-α, and INF-γ, and salvaged the clinical deterioration observed in early stages of ARDS. When the clinical, biomarker and haematological parameters indicate advanced sepsis with impending MOSF, other rescue measures should be instituted to save the patient from fatal outcome. The three patients received Itolizumab while two patients showed improvements due to early institution of therapy, the third patient, in advanced sepsis led to rapid deterioration of clinical condition and death.
{"title":"Early intervention of ARDS using anti-CD6 monoclonal antibody Itolizumab: Case series of clinical evidence","authors":"Sudershana Patil","doi":"10.18231/j.ijirm.2022.041","DOIUrl":"https://doi.org/10.18231/j.ijirm.2022.041","url":null,"abstract":"The case series of three patients is an attempt to report the importance of early use of Itolizumab in the treatment of non-COVID 19 acute respiratory distress syndrome (ARDS) admitted to the intensive care unit. Monitoring total counts, oxygen requirements, respiratory capacity, and sepsis biomarkers along with strong clinical history and presentation helped in determining the stage of sepsis, allowing the treating physician to prescribe Itolizumab as the treatment of choice when septic shock and complications such as multiple (greater than or equal to 2) organ system failure MOSF has not set in. The efficacy of Itolizumab in this clinical setting was preventative as it blocked the CD6+ receptors, preventing activation of inflammatory reaction and release of large amounts of pro-inflammatory mediators including IL-1, IL-6, TNF-α, and INF-γ, and salvaged the clinical deterioration observed in early stages of ARDS. When the clinical, biomarker and haematological parameters indicate advanced sepsis with impending MOSF, other rescue measures should be instituted to save the patient from fatal outcome. The three patients received Itolizumab while two patients showed improvements due to early institution of therapy, the third patient, in advanced sepsis led to rapid deterioration of clinical condition and death.","PeriodicalId":14503,"journal":{"name":"IP Indian Journal of Immunology and Respiratory Medicine","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79868064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：