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Early-Childhood Tablet Use and Outbursts of Anger. 儿童早期使用平板电脑与愤怒情绪的爆发
IF 24.7 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-01 DOI: 10.1001/jamapediatrics.2024.2511
Caroline Fitzpatrick, Pedro Mario Pan, Annie Lemieux, Elizabeth Harvey, Fabricio de Andrade Rocha, Gabrielle Garon-Carrier

Importance: Tablet use continues to increase in preschool-aged children. The use of mobile devices has been linked to child emotional dysregulation. However, few studies have been able to show a clear direction of association between child tablet use and the development of self-regulation skills. In addition, few studies have modeled within-person associations over time.

Objective: To estimate how child tablet use contributes to expressions of anger and frustration across the ages of 3.5 to 5.5 years at the within-person level. The study team also examined the extent to which associations are bidirectional to clarify the direction of the correlations.

Design, setting, and participants: This prospective, community-based convenience sample of 315 parents of preschool-aged children from Nova Scotia, Canada, was studied repeatedly at the ages of 3.5 (2020), 4.5 (2021), and 5.5 years (2022) during the COVID-19 pandemic. All analyses were conducted between October 5, 2023, and December 15, 2023.

Exposure: Parent-reported tablet use at the ages of 3.5, 4.5, and 5.5 years.

Main outcome and measures: Parents reported child expressions of anger/frustration at the ages of 3.5, 4.5, and 5.5 years using the Children's Behavior Questionnaire.

Results: The sample was equally distributed across child sex (171 were identified by parents as being born boys [54%] and 144 as girls [46%]). Most reported being Canadian (287 [91.0%]) and married (258 [82.0%]). A random-intercept cross-lagged panel model revealed that a 1-SD increase in tablet use at 3.5 years (corresponding to 1.22 hours per day) was associated with a 22% SD scale increase in anger/frustration at age 4.5 years (standardized coefficient = 0.22; 95% CI, 0.01-0.44). A 1 SD scale increase in anger and frustration at 4.5 years was associated with a 22% SD (corresponding to 0.28 hours per day) increase in tablet use at 5.5 years (standardized coefficient = 0.22; 95% CI, 0.01-0.43).

Conclusion and relevance: In this study, child tablet use at age 3.5 years was associated with more expressions of anger and frustration by the age of 4.5 years. Child proneness to anger/frustration at age 4.5 years was then associated with more use of tablets by age 5.5 years. These results suggest that early-childhood tablet use may contribute to a cycle that is deleterious for emotional regulation.

重要性:学龄前儿童使用平板电脑的人数不断增加。使用移动设备与儿童情绪失调有关。然而,很少有研究能够明确显示儿童使用平板电脑与自我调节能力发展之间的关联方向。此外,很少有研究模拟了随时间推移的人内关联:估计儿童平板电脑的使用对 3.5 至 5.5 岁儿童愤怒和沮丧情绪表达的影响。研究小组还研究了相关性的双向程度,以明确相关性的方向:在 COVID-19 大流行期间,对加拿大新斯科舍省 315 名学龄前儿童的父母在 3.5 岁(2020 年)、4.5 岁(2021 年)和 5.5 岁(2022 年)时的情况进行了重复研究。所有分析均在 2023 年 10 月 5 日至 2023 年 12 月 15 日期间进行:主要结果和测量指标:主要结果和测量指标:家长使用儿童行为问卷报告孩子在3.5、4.5和5.5岁时的愤怒/沮丧表现:样本中儿童的性别分布相当(171 名儿童的父母确认其为男孩[54%],144 名为女孩[46%])。大多数人称自己是加拿大人(287 人 [91.0%])和已婚人士(258 人 [82.0%])。随机截距交叉滞后面板模型显示,3.5 岁时平板电脑使用量每增加 1 标度(相当于每天 1.15 小时),4.5 岁时愤怒/沮丧程度就会增加 22% 标度(标准化系数 = 0.22;95% CI,0.01-0.44)。4.5 岁时,愤怒和沮丧程度每增加 1 SD,5.5 岁时平板电脑使用量就会增加 22% SD(相当于每天 0.28 小时)(标准化系数 = 0.22;95% CI,0.01-0.43):在这项研究中,儿童在 3.5 岁时使用平板电脑与 4.5 岁时更多地表达愤怒和沮丧有关。儿童在 4.5 岁时易愤怒/沮丧与 5.5 岁时更多地使用平板电脑有关。这些结果表明,儿童早期使用平板电脑可能会造成一种对情绪调节有害的循环。
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引用次数: 0
Emergency Severity Index Version 4 and Triage of Pediatric Emergency Department Patients. 急诊严重程度指数第 4 版与儿科急诊患者的分诊。
IF 24.7 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-01 DOI: 10.1001/jamapediatrics.2024.2671
Dana R Sax, E Margaret Warton, Mamata V Kene, Dustin W Ballard, Tina J Vitale, Jenna A Timm, Eloa S Adams, Katherine R McGauhey, Jesse M Pines, Mary E Reed

Importance: Most emergency departments (EDs) across the US use the Emergency Severity Index (ESI) to predict acuity and resource needs. A comprehensive assessment of ESI accuracy among pediatric patients is lacking.

Objective: To assess the frequency of mistriage using ESI (version 4) among pediatric ED visits using automated measures of mistriage and identify characteristics associated with mistriage.

Design, setting, and participants: This cohort study used operational measures for each ESI level to classify encounters as undertriaged, overtriaged, or correctly triaged to assess the accuracy of the ESI and identify characteristics of mistriage. Participants were pediatric patients at 21 EDs within Kaiser Permanente Northern California from January 1, 2016, to December 31, 2020. During that time, version 4 of the ESI was in use by these EDs. Visits with missing ESI, incomplete ED time variables, patients transferred from another ED, and those who left against medical advice or without being seen were excluded. Data were analyzed between January 2022 and June 2023.

Exposures: Assigned ESI level.

Main outcomes and measures: Rates of undertriage and overtriage by assigned ESI level based on mistriage algorithm, patient and visit characteristics associated with undertriage and overtriage.

Results: This study included 1 016 816 pediatric ED visits; the mean (SD) age of patients was 7.3 (5.6) years, 479 610 (47.2%) were female, and 537 206 (52.8%) were male. Correct triage occurred in 346 918 visits (34.1%; 95% CI, 34.0%-34.2%), while overtriage and undertriage occurred in 594 485 visits (58.5%; 95% CI, 58.4%-58.6%) and 75 413 visits (7.4%; 95% CI, 7.4%-7.5%), respectively. In adjusted analyses, undertriage was more common among children at least 6 years old compared with those younger 6 years; male patients compared with female patients; patients with Asian, Black, or Hispanic or other races or ethnicities compared with White patients; patients with comorbid illnesses compared with those without; and patients who arrived by ambulance compared with nonambulance patients.

Conclusions and relevance: This multicenter retrospective study found that mistriage with ESI version 4 was common in pediatric ED visits. There is an opportunity to improve pediatric ED triage, both in early identification of critically ill patients (limit undertriage) and in more accurate identification of low-acuity patients with low resource needs (limit overtriage). Future research should include assessments based on version 5 of the ESI, which was released after this study was completed.

重要性:美国大多数急诊科(ED)都使用急诊严重程度指数(ESI)来预测病情严重程度和资源需求。目前还缺乏对儿科患者ESI准确性的全面评估:目的:使用ESI(第4版)评估儿科急诊室就诊者中误诊的频率,并确定与误诊相关的特征:这项队列研究使用每个 ESI 级别的操作措施将就诊情况分为分流不足、分流过度或正确分流,以评估 ESI 的准确性并确定误诊的特征。参与者为北加州凯泽医疗集团下属 21 家急诊室的儿科患者,时间为 2016 年 1 月 1 日至 2020 年 12 月 31 日。在此期间,这些急诊室使用的是第 4 版 ESI。缺失 ESI 的就诊、不完整的 ED 时间变量、从其他 ED 转来的患者以及不听医嘱离开或未就诊的患者均被排除在外。数据分析时间为 2022 年 1 月至 2023 年 6 月:主要结果和测量指标:主要结果和测量指标:根据误诊算法分配的ESI级别的误诊率和超诊率,与误诊和超诊相关的患者和就诊特征:这项研究包括 1 016 816 名儿科急诊就诊者;患者的平均年龄(SD)为 7.3 (5.6)岁,女性 479 610 人(47.2%),男性 537 206 人(52.8%)。346 918 人次(34.1%;95% CI,34.0%-34.2%)得到了正确分流,而 594 485 人次(58.5%;95% CI,58.4%-58.6%)和 75 413 人次(7.4%;95% CI,7.4%-7.5%)分别出现了分流过度和分流不足。在调整后的分析中,至少 6 岁的儿童与 6 岁以下的儿童相比,男性患者与女性患者相比,亚裔、黑人、西班牙裔或其他种族或族裔患者与白人患者相比,合并症患者与非合并症患者相比,以及乘救护车就诊的患者与非乘救护车就诊的患者相比,误诊率更高:这项多中心回顾性研究发现,在儿科急诊就诊中,ESI 第 4 版的误诊现象很常见。现在有机会改进儿科急诊室分诊,包括早期识别危重病人(限制误诊)和更准确地识别资源需求低的低急诊病人(限制过度分诊)。未来的研究应包括基于ESI第5版的评估,该版本是在本研究完成后发布的。
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引用次数: 0
Error in the Figure. 图中的错误。
IF 24.7 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-01 DOI: 10.1001/jamapediatrics.2024.3314
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引用次数: 0
Intimate Partner Violence and Parenting. 亲密伴侣暴力与养育子女。
IF 24.7 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-01 DOI: 10.1001/jamapediatrics.2024.2705
Jeff R Temple, Elizabeth Baumler, Leila Wood
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引用次数: 0
Infant Feeding and Weight Trajectories in the Eat, Sleep, Console Trial: A Secondary Analysis of a Randomized Clinical Trial. 吃、睡、控制试验中的婴儿喂养和体重轨迹:随机临床试验的二次分析。
IF 24.7 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-01 DOI: 10.1001/jamapediatrics.2024.2578
Stephanie L Merhar, Zhuopei Hu, Lori A Devlin, Songthip T Ounpraseuth, Alan E Simon, P Brian Smith, Michele C Walsh, Jeannette Y Lee, Abhik Das, Rosemary D Higgins, Margaret M Crawford, Ward Rice, David A Paul, Jessie R Maxwell, Sucheta D Telang, Camille M Fung, Tanner Wright, Anne-Marie Reynolds, Devon Hahn, Julie Ross, Jennifer M McAllister, Moira Crowley, Sophie K Shaikh, Lori Christ, Jaime Brown, Julie Riccio, Kara Wong Ramsey, Erica F Braswell, Lauren Tucker, Karen McAlmon, Krishna Dummula, Julie Weiner, Jessica R White, Meghan P Howell, Sarah Newman, Jessica N Snowden, Leslie W Young

Importance: Infants with neonatal opioid withdrawal syndrome (NOWS) cared for with the Eat, Sleep, Console (ESC) care approach receive less pharmacologic treatment and have shorter hospital stays compared to usual care with the Finnegan Neonatal Abstinence Scoring Tool, but the effects of these approaches on feeding and weight are unknown.

Objective: To evaluate feeding practices and weight trajectories in infants cared for with ESC vs usual care.

Design, setting, and participants: ESC-NOW is a cluster randomized trial of infants with NOWS born at 36 weeks' gestation or later at 26 US hospitals from September 2020 to March 2022. Each site transitioned from usual care to ESC (the study intervention) at a randomized time. Feeding was per site practice and not specified by the intervention. Feeding and weight outcomes were assessed at hospital discharge.

Intervention: ESC vs usual care.

Main outcomes and measures: Outcomes include prospectively identified secondary end points related to feeding and weight. z Scores were used for growth to account for corrected gestational age at the time of measurement. All analyses were intention to treat and adjusted for study design. Maternal/infant characteristics were included in adjusted models.

Results: The analyses included 1305 infants (702 in usual care and 603 in ESC; mean [SD] gestational age, 38.6 [1.3] weeks; 655 [50.2%] male and 650 [49.8%] female). Baseline demographic characteristics were similar between groups. The proportion of breastfed infants was higher in the ESC group (52.7% vs 41.7%; absolute difference, 11%; 95% CI, 1.0-20.9). A higher proportion of infants cared for with ESC received exclusive breast milk (15.1% vs 6.7%; absolute difference, 8.4%; 95% CI, 0.9-5.8) or any breast milk (38.8% vs 27.4%; absolute difference, 11.4%; 95% CI, 0.2-23.1) and were directly breastfeeding at discharge (35.2% vs 19.5%; absolute difference, 15.7%; 95% CI, 4.1-27.3). There was no difference in proportion of infants with weight loss greater than 10% or maximum percentage weight loss, although infants cared for with ESC had a lower weight z score on day of life 3 (-1.08 vs -1.01; absolute difference, 0.07; 95% CI, 0.02-0.12). When pharmacologic treatment was added into the model, no breastfeeding outcomes were statistically significant.

Conclusions and relevance: In this study, infants cared for with ESC were more likely to initiate and continue breastfeeding and had no difference in percentage weight loss. The improvement in breastfeeding with ESC may be driven by reduction in pharmacologic treatment and provision of effective nonpharmacologic care.

Trial registration: ClinicalTrials.gov Identifier: NCT04057820.

重要性:与使用芬尼根新生儿戒断评分工具的常规护理相比,使用 "吃、睡、控制"(ESC)护理方法护理的新生儿阿片戒断综合征(NOWS)婴儿接受的药物治疗更少,住院时间更短,但这些方法对喂养和体重的影响尚不清楚:目的:评估ESC护理与常规护理对婴儿喂养方式和体重变化的影响:ESC-NOW是一项分组随机试验,对象是2020年9月至2022年3月期间在美国26家医院出生的妊娠36周或36周以后的NOWS婴儿。每家医院在随机时间从常规护理过渡到ESC(研究干预)。喂养按医院惯例进行,干预措施未作规定。出院时对喂养和体重结果进行评估:干预措施:ESC vs 常规护理:主要结果和测量指标:结果包括前瞻性确定的与喂养和体重相关的次要终点。所有分析均为意向治疗,并根据研究设计进行了调整。调整后的模型还包括母婴特征:分析包括 1305 名婴儿(702 名接受常规护理,603 名接受 ESC;平均 [SD] 胎龄为 38.6 [1.3] 周;655 名 [50.2%] 男婴和 650 名 [49.8%] 女婴)。各组的基线人口特征相似。ESC组母乳喂养婴儿的比例更高(52.7% vs 41.7%;绝对差异,11%;95% CI,1.0-20.9)。接受ESC护理的婴儿中,接受纯母乳喂养(15.1% vs 6.7%;绝对差异,8.4%;95% CI,0.9-5.8)或任何母乳喂养(38.8% vs 27.4%;绝对差异,11.4%;95% CI,0.2-23.1)以及出院时直接母乳喂养的比例更高(35.2% vs 19.5%;绝对差异,15.7%;95% CI,4.1-27.3)。虽然使用ESC护理的婴儿在出生后第3天的体重z评分较低(-1.08 vs -1.01; 绝对差异,0.07; 95% CI, 0.02-0.12),但体重减轻超过10%的婴儿比例或体重减轻的最大百分比没有差异。将药物治疗加入模型后,母乳喂养的结果均无统计学意义:在这项研究中,使用ESC护理的婴儿更有可能开始并继续母乳喂养,体重减轻的百分比没有差异。ESC改善母乳喂养的原因可能是减少了药物治疗并提供了有效的非药物护理:试验注册:ClinicalTrials.gov Identifier:试验注册:ClinicalTrials.gov Identifier:NCT04057820。
{"title":"Infant Feeding and Weight Trajectories in the Eat, Sleep, Console Trial: A Secondary Analysis of a Randomized Clinical Trial.","authors":"Stephanie L Merhar, Zhuopei Hu, Lori A Devlin, Songthip T Ounpraseuth, Alan E Simon, P Brian Smith, Michele C Walsh, Jeannette Y Lee, Abhik Das, Rosemary D Higgins, Margaret M Crawford, Ward Rice, David A Paul, Jessie R Maxwell, Sucheta D Telang, Camille M Fung, Tanner Wright, Anne-Marie Reynolds, Devon Hahn, Julie Ross, Jennifer M McAllister, Moira Crowley, Sophie K Shaikh, Lori Christ, Jaime Brown, Julie Riccio, Kara Wong Ramsey, Erica F Braswell, Lauren Tucker, Karen McAlmon, Krishna Dummula, Julie Weiner, Jessica R White, Meghan P Howell, Sarah Newman, Jessica N Snowden, Leslie W Young","doi":"10.1001/jamapediatrics.2024.2578","DOIUrl":"10.1001/jamapediatrics.2024.2578","url":null,"abstract":"<p><strong>Importance: </strong>Infants with neonatal opioid withdrawal syndrome (NOWS) cared for with the Eat, Sleep, Console (ESC) care approach receive less pharmacologic treatment and have shorter hospital stays compared to usual care with the Finnegan Neonatal Abstinence Scoring Tool, but the effects of these approaches on feeding and weight are unknown.</p><p><strong>Objective: </strong>To evaluate feeding practices and weight trajectories in infants cared for with ESC vs usual care.</p><p><strong>Design, setting, and participants: </strong>ESC-NOW is a cluster randomized trial of infants with NOWS born at 36 weeks' gestation or later at 26 US hospitals from September 2020 to March 2022. Each site transitioned from usual care to ESC (the study intervention) at a randomized time. Feeding was per site practice and not specified by the intervention. Feeding and weight outcomes were assessed at hospital discharge.</p><p><strong>Intervention: </strong>ESC vs usual care.</p><p><strong>Main outcomes and measures: </strong>Outcomes include prospectively identified secondary end points related to feeding and weight. z Scores were used for growth to account for corrected gestational age at the time of measurement. All analyses were intention to treat and adjusted for study design. Maternal/infant characteristics were included in adjusted models.</p><p><strong>Results: </strong>The analyses included 1305 infants (702 in usual care and 603 in ESC; mean [SD] gestational age, 38.6 [1.3] weeks; 655 [50.2%] male and 650 [49.8%] female). Baseline demographic characteristics were similar between groups. The proportion of breastfed infants was higher in the ESC group (52.7% vs 41.7%; absolute difference, 11%; 95% CI, 1.0-20.9). A higher proportion of infants cared for with ESC received exclusive breast milk (15.1% vs 6.7%; absolute difference, 8.4%; 95% CI, 0.9-5.8) or any breast milk (38.8% vs 27.4%; absolute difference, 11.4%; 95% CI, 0.2-23.1) and were directly breastfeeding at discharge (35.2% vs 19.5%; absolute difference, 15.7%; 95% CI, 4.1-27.3). There was no difference in proportion of infants with weight loss greater than 10% or maximum percentage weight loss, although infants cared for with ESC had a lower weight z score on day of life 3 (-1.08 vs -1.01; absolute difference, 0.07; 95% CI, 0.02-0.12). When pharmacologic treatment was added into the model, no breastfeeding outcomes were statistically significant.</p><p><strong>Conclusions and relevance: </strong>In this study, infants cared for with ESC were more likely to initiate and continue breastfeeding and had no difference in percentage weight loss. The improvement in breastfeeding with ESC may be driven by reduction in pharmacologic treatment and provision of effective nonpharmacologic care.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT04057820.</p>","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":" ","pages":"976-984"},"PeriodicalIF":24.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11320328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time to Gender-Affirming Hormone Therapy Among US Military-Affiliated Adolescents and Young Adults. 美军青少年和年轻成年人接受性别确认激素治疗的时间。
IF 24.7 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-01 DOI: 10.1001/jamapediatrics.2024.2835
Evan R Locke, Krista B Highland, Jennifer A Thornton, Kevin W Sunderland, Wendy Funk, Veronika Pav, Rick Brydum, Noelle S Larson, Natasha A Schvey, Christina M Roberts, David A Klein
<p><strong>Importance: </strong>Use of exogenous sex steroid hormones, when indicated, may improve outcomes in adolescents and young adults with gender incongruence. Little is known about factors associated with the time from diagnosis of gender dysphoria to initiation of gender-affirming hormone therapy. Identification of inequities in time to treatment may have clinical, policy, and research implications.</p><p><strong>Objective: </strong>To evaluate factors associated with time to initiation of gender-affirming hormone therapy after a diagnosis of gender dysphoria in adolescents and young adults receiving care within the US Military Health System.</p><p><strong>Design, setting, and participants: </strong>This retrospective cohort study used TRICARE Prime billing and pharmacy data contained in the Military Health System Data Repository. Patients aged 14 to 22 years, excluding service members and their spouses, who received a diagnosis of gender dysphoria between September 1, 2016, and December 31, 2021, were included. The data were analyzed between August 30 and October 12, 2023.</p><p><strong>Exposures: </strong>Included patient characteristics were race and ethnicity, age group, first sex assigned in the medical record, and TRICARE Prime sponsor military rank and service at the time of diagnosis. Health care and contextual characteristics included the year of diagnosis and the primary system in which the patient received health care.</p><p><strong>Main outcomes and measures: </strong>The primary outcome was the time between initial diagnosis of gender dysphoria to the first prescription for gender-affirming hormone medication within a 2-year period. A Poisson generalized additive model was used to evaluate this primary outcome. Adjusted probability estimates were calculated per specified reference categories.</p><p><strong>Results: </strong>Of the 3066 patients included (median [IQR] age, 17 [15-19] years; 2259 with first assigned gender marker of female [74%]), an unadjusted survival model accounting for censoring indicated that 37% (95% CI, 35%-39%) initiated therapy by 2 years. Age-adjusted curves indicated that the proportion initiating therapy by 2 years increased by age category (aged 14-16 years, 25%; aged 17-18 years, 39%; aged 19-22 years, 55%). Incidence rate ratios (IRRs) and 2-year adjusted probabilities indicated that longer times to hormone initiation were experienced by adolescents aged 14 to 16 years (IRR, 0.36; 95% CI, 0.30-0.44) and 17 to 18 years (IRR, 0.66; 95% CI, 0.54-0.79) compared with young adults aged 19 to 22 years and Black compared with White adolescents (IRR, 0.73; 95% CI, 0.54-0.99). Senior officer compared with junior enlisted insurance sponsor rank (IRR, 1.93; 95% CI, 1.04-3.55) and civilian compared with military health care setting (IRR, 1.21; 95% CI, 1.02-1.43) was associated with shorter time to hormone initiation.</p><p><strong>Conclusions and relevance: </strong>In this cohort study, most adolescents and
重要性:如果有必要,使用外源性性甾体激素可以改善患有性别不协调的青少年和年轻成年人的治疗效果。人们对从确诊性别障碍到开始接受性别确认激素治疗的时间相关因素知之甚少。发现治疗时间上的不平等可能会对临床、政策和研究产生影响:目的:评估在美国军事医疗系统内接受治疗的青少年和年轻成年人在确诊性别障碍后开始接受性别确认激素治疗的时间相关因素:这项回顾性队列研究使用了军事医疗系统数据存储库(Military Health System Data Repository)中的 TRICARE Prime 账单和药房数据。研究对象包括在 2016 年 9 月 1 日至 2021 年 12 月 31 日期间确诊为性别障碍的 14 至 22 岁患者(不包括现役军人及其配偶)。数据分析时间为 2023 年 8 月 30 日至 10 月 12 日:纳入的患者特征包括种族和民族、年龄组、病历中分配的第一性别以及诊断时的 TRICARE Prime 赞助军衔和服役情况。医疗保健和环境特征包括诊断年份和患者接受医疗保健的主要系统:主要结果和测量指标:主要结果是在两年时间内,从最初诊断出性别障碍到首次开具确认性别的激素药物处方的时间。采用泊松广义相加模型对这一主要结果进行评估。根据指定的参考类别计算调整后的概率估计值:在纳入的 3066 名患者中(中位数[IQR]年龄为 17 [15-19]岁;2259 名首次分配的性别标记为女性[74%]),考虑到人口普查的未调整生存模型显示,37%(95% CI,35%-39%)的患者在 2 年内开始接受治疗。年龄调整曲线显示,2 年前开始治疗的比例随年龄的增加而增加(14-16 岁,25%;17-18 岁,39%;19-22 岁,55%)。发病率比(IRR)和 2 年调整概率表明,与 19-22 岁的年轻人相比,14-16 岁(IRR,0.36;95% CI,0.30-0.44)和 17-18 岁(IRR,0.66;95% CI,0.54-0.79)的青少年开始使用激素的时间更长;与白人青少年相比,黑人青少年开始使用激素的时间更长(IRR,0.73;95% CI,0.54-0.99)。高级军官与低级士兵相比(IRR,1.93;95% CI,1.04-3.55),平民与军队医疗环境相比(IRR,1.21;95% CI,1.02-1.43),与较短的激素启动时间有关:在这项队列研究中,大多数被诊断出患有性别障碍的青少年和年轻人在接受美国军方的医疗服务时,并没有在确诊后两年内开始接受外源性性类固醇激素治疗。治疗时间上的不平等表明,有必要识别并减少治疗障碍。
{"title":"Time to Gender-Affirming Hormone Therapy Among US Military-Affiliated Adolescents and Young Adults.","authors":"Evan R Locke, Krista B Highland, Jennifer A Thornton, Kevin W Sunderland, Wendy Funk, Veronika Pav, Rick Brydum, Noelle S Larson, Natasha A Schvey, Christina M Roberts, David A Klein","doi":"10.1001/jamapediatrics.2024.2835","DOIUrl":"10.1001/jamapediatrics.2024.2835","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Importance: &lt;/strong&gt;Use of exogenous sex steroid hormones, when indicated, may improve outcomes in adolescents and young adults with gender incongruence. Little is known about factors associated with the time from diagnosis of gender dysphoria to initiation of gender-affirming hormone therapy. Identification of inequities in time to treatment may have clinical, policy, and research implications.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To evaluate factors associated with time to initiation of gender-affirming hormone therapy after a diagnosis of gender dysphoria in adolescents and young adults receiving care within the US Military Health System.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design, setting, and participants: &lt;/strong&gt;This retrospective cohort study used TRICARE Prime billing and pharmacy data contained in the Military Health System Data Repository. Patients aged 14 to 22 years, excluding service members and their spouses, who received a diagnosis of gender dysphoria between September 1, 2016, and December 31, 2021, were included. The data were analyzed between August 30 and October 12, 2023.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Exposures: &lt;/strong&gt;Included patient characteristics were race and ethnicity, age group, first sex assigned in the medical record, and TRICARE Prime sponsor military rank and service at the time of diagnosis. Health care and contextual characteristics included the year of diagnosis and the primary system in which the patient received health care.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main outcomes and measures: &lt;/strong&gt;The primary outcome was the time between initial diagnosis of gender dysphoria to the first prescription for gender-affirming hormone medication within a 2-year period. A Poisson generalized additive model was used to evaluate this primary outcome. Adjusted probability estimates were calculated per specified reference categories.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Of the 3066 patients included (median [IQR] age, 17 [15-19] years; 2259 with first assigned gender marker of female [74%]), an unadjusted survival model accounting for censoring indicated that 37% (95% CI, 35%-39%) initiated therapy by 2 years. Age-adjusted curves indicated that the proportion initiating therapy by 2 years increased by age category (aged 14-16 years, 25%; aged 17-18 years, 39%; aged 19-22 years, 55%). Incidence rate ratios (IRRs) and 2-year adjusted probabilities indicated that longer times to hormone initiation were experienced by adolescents aged 14 to 16 years (IRR, 0.36; 95% CI, 0.30-0.44) and 17 to 18 years (IRR, 0.66; 95% CI, 0.54-0.79) compared with young adults aged 19 to 22 years and Black compared with White adolescents (IRR, 0.73; 95% CI, 0.54-0.99). Senior officer compared with junior enlisted insurance sponsor rank (IRR, 1.93; 95% CI, 1.04-3.55) and civilian compared with military health care setting (IRR, 1.21; 95% CI, 1.02-1.43) was associated with shorter time to hormone initiation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions and relevance: &lt;/strong&gt;In this cohort study, most adolescents and","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":" ","pages":"1049-1056"},"PeriodicalIF":24.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11334009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hospitalizations for Multisystem Inflammatory Syndrome in Children (MIS-C) in US Children's Hospitals in 2023 vs 2021. 2023 年与 2021 年美国儿童医院儿童多系统炎症综合征 (MIS-C) 住院人数对比。
IF 24.7 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-01 DOI: 10.1001/jamapediatrics.2024.2882
Anne K Jackson, Patrick W Brady, Matt Hall, Matthew J Molloy, Katherine A Auger
{"title":"Hospitalizations for Multisystem Inflammatory Syndrome in Children (MIS-C) in US Children's Hospitals in 2023 vs 2021.","authors":"Anne K Jackson, Patrick W Brady, Matt Hall, Matthew J Molloy, Katherine A Auger","doi":"10.1001/jamapediatrics.2024.2882","DOIUrl":"10.1001/jamapediatrics.2024.2882","url":null,"abstract":"","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":" ","pages":"1078-1080"},"PeriodicalIF":24.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11320329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Housing Instability and Children's Health and Education. 住房不稳定与儿童健康和教育。
IF 24.7 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-01 DOI: 10.1001/jamapediatrics.2024.3172
Aashna Lal, Natalie Slopen
{"title":"Housing Instability and Children's Health and Education.","authors":"Aashna Lal, Natalie Slopen","doi":"10.1001/jamapediatrics.2024.3172","DOIUrl":"10.1001/jamapediatrics.2024.3172","url":null,"abstract":"","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":" ","pages":"967-968"},"PeriodicalIF":24.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intermittent Energy Restriction for Adolescents With Obesity: The Fast Track to Health Randomized Clinical Trial. 针对青少年肥胖症的间歇性能量限制:健康快车道随机临床试验》。
IF 24.7 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-01 DOI: 10.1001/jamapediatrics.2024.2869
Natalie B Lister, Louise A Baur, Eve T House, Shirley Alexander, Justin Brown, Clare E Collins, Christopher T Cowell, Kaitlin Day, Sarah P Garnett, Megan L Gow, Alicia M Grunseit, Maddison Henderson, Mary-Kate Inkster, Cathy Kwok, Sarah Lang, Susan J Paxton, Helen Truby, Krista A Varady, Hiba Jebeile
<p><strong>Importance: </strong>Adolescent obesity requires effective and accessible treatment. Intensive dietary interventions have the potential to be used as adjunctive therapy for behavioral weight management.</p><p><strong>Objective: </strong>To examine the effectiveness of 2 diet therapies, delivered as part of an intensive behavioral weight management intervention, in adolescents with metabolic complications associated with obesity.</p><p><strong>Design, setting, and participants: </strong>This multisite, 52-week randomized clinical trial was conducted from January 31, 2018, to March 31, 2023, at 2 tertiary pediatric centers in Australia. Adolescents (aged 13-17 years) with obesity and 1 or more associated complications were included.</p><p><strong>Interventions: </strong>Intensive behavioral interventions, delivered by a multidisciplinary team, comparing intermittent energy restriction (IER) or continuous energy restriction (CER), with 3 phases: very low-energy diet (weeks 0-4), intensive intervention (weeks 5-16), and continued intervention and/or maintenance (weeks 17-52).</p><p><strong>Main outcomes and measures: </strong>The primary outcome was body mass index (BMI) z score at 52 weeks in the IER vs CER group. Anthropometry, body composition, and cardiometabolic health were assessed at baseline and 52 weeks. The BMI z score and percentiles were determined using Centers for Disease Control and Prevention growth charts. Insulin resistance, dyslipidemia, and elevated hepatic function were assessed.</p><p><strong>Results: </strong>A total of 141 adolescents (median [IQR] age, 14.8 [12.9-17.9] years; 71 male [50.4%]) were enrolled, 71 in the IER group and 70 in the CER group, and 97 (68.8%) completed the intervention, 43 in the IER group and 54 in the CER group. At week 52, both groups had reduced BMI z scores (estimated marginal mean change, -0.28 [95% CI, -0.37 to -0.20] for IER and -0.28 [95% CI, -0.36 to -0.20] for CER) and reduced BMI expressed as a percentage of the 95th percentile (estimated marginal mean change, -9.56 [95% CI, -12.36 to -6.83] for IER and -9.23 [95% CI, -11.82 to -6.64] for CER). No differences were found in body composition or cardiometabolic outcomes between the groups. Both groups had a reduction in the occurrence of insulin resistance (from 52 of 68 [76.5%] to 32 of 56 [57.1%] in the IER group and from 59 of 68 [86.8%] to 31 of 60 [57.1%] in the CER group) at week 16; however, at week 52, this effect was observed in the CER group only (from 59 of 68 [86.7%] to 30 of 49 [61.2%]). The occurrence of dyslipidemia was unchanged between baseline and week 52 (60 of 137 [42.6%] and 37 of 87 [42.5%], respectively), with a small improvement in occurrence of impaired hepatic function tests (37 of 139 [27.0%] and 15 of 87 [17.2%], respectively). No differences were found in dyslipidemia or hepatic function between groups.</p><p><strong>Conclusions and relevance: </strong>These findings suggest that for adolescents with obe
重要性:青少年肥胖症需要有效且方便的治疗。强化饮食干预有可能作为行为体重管理的辅助疗法:目的:研究作为强化行为体重管理干预措施一部分的两种饮食疗法对患有肥胖相关代谢并发症的青少年的有效性:这项多地点、为期 52 周的随机临床试验于 2018 年 1 月 31 日至 2023 年 3 月 31 日在澳大利亚的 2 家三级儿科中心进行。研究对象包括患有肥胖症和一种或多种相关并发症的青少年(13-17 岁):由多学科团队提供强化行为干预,比较间歇性能量限制(IER)或持续性能量限制(CER),分为3个阶段:极低能量饮食(0-4周)、强化干预(5-16周)、持续干预和/或维持(17-52周):主要结果:IER 组与 CER 组的主要结果是 52 周时的体重指数(BMI)Z 值。在基线和 52 周时对人体测量、身体成分和心脏代谢健康进行评估。BMI z 分数和百分位数是根据美国疾病控制和预防中心的生长图表确定的。对胰岛素抵抗、血脂异常和肝功能升高进行了评估:共有 141 名青少年(中位数[IQR]年龄,14.8 [12.9-17.9] 岁;71 名男性[50.4%])参加了干预活动,其中 71 人参加了 IER 组,70 人参加了 CER 组,97 人(68.8%)完成了干预活动,其中 43 人参加了 IER 组,54 人参加了 CER 组。第52周时,两组的BMI z得分均有所下降(估计边际平均变化,IER为-0.28 [95% CI, -0.37 to -0.20],CER为-0.28 [95% CI, -0.36 to -0.20]),BMI占第95百分位数的百分比也有所下降(估计边际平均变化,IER为-9.56 [95% CI, -12.36 to -6.83],CER为-9.23 [95% CI, -11.82 to -6.64])。两组在身体成分或心脏代谢结果方面没有差异。在第16周时,两组的胰岛素抵抗发生率都有所下降(IER组从68人中的52人[76.5%]降至56人中的32人[57.1%],CER组从68人中的59人[86.8%]降至60人中的31人[57.1%]);但在第52周时,只有CER组观察到了这种效果(从68人中的59人[86.7%]降至49人中的30人[61.2%])。血脂异常的发生率在基线和第 52 周之间没有变化(分别为 137 例中的 60 例[42.6%]和 87 例中的 37 例[42.5%]),肝功能检测受损的发生率略有改善(分别为 139 例中的 37 例[27.0%]和 87 例中的 15 例[17.2%])。各组之间在血脂异常或肝功能方面没有发现差异:这些研究结果表明,对于患有肥胖相关并发症的青少年,IER可被纳入行为体重管理计划中,提供CER之外的另一种选择,并为参与者提供更多选择。试验注册:http://anzctr.org.au Identifier:ACTRN12617001630303。
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引用次数: 0
Error in Author Affiliation. 作者隶属关系错误。
IF 24.7 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-01 DOI: 10.1001/jamapediatrics.2024.3393
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引用次数: 0
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JAMA Pediatrics
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