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The Child Opportunity Index and Other Social Determinants of Health Neighborhood Indexes: Important Considerations for Choosing the Correct Index. 儿童机会指数和其他健康的社会决定因素邻里指数:选择正确指数的重要考虑因素。
IF 26.1 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-14 DOI: 10.1001/jamapediatrics.2024.3146
Emily M Bucholz,Amanda D McCormick,Christina Ronai
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引用次数: 0
Portal Confidentiality Concerns and Health Information Sharing and Access. 门户网站保密问题与健康信息共享和访问。
IF 24.7 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-07 DOI: 10.1001/jamapediatrics.2024.3688
Marianne Sharko, Stephanie Niño de Rivera, Natalie Benda, Meghan Reading Turchioe, Xiaoyue Ma, Ruth Masterson Creber, Erika L Abramson
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引用次数: 0
Evaluating Pediatric Macrolide Allergy Using Direct Graded Oral Challenges. 用直接分级口服挑战法评估小儿对大环内酯类药物的过敏反应
IF 24.7 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-07 DOI: 10.1001/jamapediatrics.2024.3685
Carly Sillcox, Sofianne Gabrielli, Andrew O'Keefe, Christine McCusker, Elissa M Abrams, Thomas Eiwegger, Adelle Atkinson, Vy Kim, Ana-Maria Copaescu, Moshe Ben-Shoshan
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引用次数: 0
Longitudinal Changes in Epigenetic Age Acceleration Across Childhood and Adolescence. 儿童和青少年时期表观遗传年龄加速度的纵向变化。
IF 24.7 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-07 DOI: 10.1001/jamapediatrics.2024.3669
Juan Del Toro, Connor Martz, Colin D Freilich, Gianna Rea-Sandin, Kristian Markon, Steve Cole, Robert F Krueger, Sylia Wilson
<p><strong>Importance: </strong>Individuals exposed to discrimination may exhibit greater epigenetic age acceleration (ie, cellular indicators of premature aging) over time, but few studies have examined longitudinal changes in epigenetic age acceleration, the heterogeneity in these changes for diverse groups of youths, and contextual explanations (ie, discrimination) for differences by ethnicity or race.</p><p><strong>Objective: </strong>To provide a descriptive illustration of changes in epigenetic age acceleration across childhood and adolescence among an ethnically and racially diverse sample of youths.</p><p><strong>Design, setting, and participants: </strong>This cohort study leveraged longitudinal data on a large sample of youths from low-income households in 20 large urban US cities who provided repeated assessments of saliva tissue samples at ages 9 and 15 years for DNA methylation analysis. Of 4898 youths from the Future of Families and Child Well-Being study, an ongoing study that oversampled children born to unmarried parents from 1998 to 2000, 2039 were included in the present analysis, as these youths had salivary DNA methylation data assayed and publicly available. Analyses were conducted from March 2023 to June 2024.</p><p><strong>Exposures: </strong>Racialized intrusive encounters with police (eg, stop and frisk and racial slurs).</p><p><strong>Main outcomes and measures: </strong>Analyses were conducted to examine longitudinal changes in salivary epigenetic age acceleration over time, whether such changes varied across ethnically and racially diverse groups of youths, and whether police intrusion was associated with variation across ethnic and racial groups.</p><p><strong>Results: </strong>Among 2039 youths (mean [SD] age at baseline, 9.27 [0.38] years; 1023 [50%] male and 1016 [50%] female; 917 [45%] Black, 430 [21%] Hispanic or Latino, 351 [17%] White, and 341 [17%] other, including multiple races and self-identified other) with salivary epigenetic clocks at 9 and 15 years of age, longitudinal results showed that White youths exhibited less accelerated epigenetic aging over time than did Black and Hispanic or Latino youths and those reporting other or multiple races or ethnicities from ages 9 to 15 years, particularly in the Hannum (B, 1.54; 95% CI, 0.36-2.18), GrimAge (B, 1.31; 95% CI, 0.68-1.97), and DunedinPACE epigenetic clocks (B, 0.27; 95% CI, 0.11-0.44). Across these clocks and the PhenoAge clock, police intrusion was associated with Black youths' more accelerated epigenetic aging (Hannum: B, 0.11; 95% CI, 0.03-0.23; GrimAge: B, 0.09; 95% CI, 0.03-0.18; PhenoAge: B, 0.08; 95% CI, 0.02-0.18; DunedinPACE: B, 0.01; 95% CI, 0.01-0.03).</p><p><strong>Conclusions and relevance: </strong>The transition from childhood to adolescence may represent a sensitive developmental period when racism can have long-term deleterious impacts on healthy human development across the life span. Future research should build on the present study
重要性:随着时间的推移,受到歧视的个体可能会表现出更大的表观遗传年龄加速(即细胞早衰指标),但很少有研究对表观遗传年龄加速的纵向变化、不同青少年群体中这些变化的异质性以及不同民族或种族差异的背景解释(即歧视)进行了研究:描述性说明不同民族和种族青少年样本在童年和青少年时期表观遗传年龄加速度的变化:这项队列研究利用了美国 20 个大城市低收入家庭青少年大样本的纵向数据,这些青少年在 9 岁和 15 岁时提供了唾液组织样本的重复评估,以进行 DNA 甲基化分析。目前正在进行的 "未来家庭和儿童福祉研究"(Future of Families and Child Well-Being study)对 1998 年至 2000 年期间未婚父母所生子女进行了超量抽样调查,在这项研究的 4898 名青少年中,有 2039 名青少年被纳入了本次分析,因为这些青少年的唾液 DNA 甲基化数据已被检测并公开。分析时间为 2023 年 3 月至 2024 年 6 月:主要结果和测量指标:主要结果和测量方法:分析唾液表观遗传年龄加速度随时间的纵向变化、这种变化在不同民族和种族的青少年群体中是否存在差异,以及警察的侵犯行为是否与不同民族和种族群体的差异有关:在 2039 名青少年中(基线年龄平均值 [SD] 为 9.27 [0.38]岁;男性 1023 人[50%],女性 1016 人[50%];917 [45%] 黑人,430 [21%] 西班牙裔或拉丁裔,351 [17%] 白人,以及 341 [17%] 其他,包括多种族和自我认同的其他)中,9 岁和 15 岁时唾液表观遗传时钟的纵向结果显示,与黑人和西班牙裔或拉丁裔青少年以及报告其他或多种族或族裔的青少年相比,白人青少年在 9 岁至 15 岁期间表现出的表观遗传加速老化程度较低,尤其是在 Hannum(B,1.54; 95% CI, 0.36-2.18), GrimAge (B, 1.31; 95% CI, 0.68-1.97), and DunedinPACE epigenetic clocks (B, 0.27; 95% CI, 0.11-0.44).在这些表观遗传时钟和 PhenoAge 表观遗传时钟中,警察入侵与黑人青少年更快的表观遗传衰老有关(Hannum:B,0.11;95% CI,0.03-0.23;GrimAge:B,0.09;95% CI,0.03-0.18;PhenoAge:B,0.08;95% CI,0.02-0.18;DunedinPACE:B,0.01;95% CI,0.01-0.03):从童年到青春期的过渡可能是一个敏感的发展时期,种族主义可能会对人类一生的健康发展产生长期的有害影响。未来的研究应在本研究的基础上,探讨哪些社会规律和政策可能会使针对少数民族和少数种族青少年的歧视永久化。
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引用次数: 0
Cannabis Use During Adolescence and Young Adulthood and Academic Achievement: A Systematic Review and Meta-Analysis. 青春期和青年期吸食大麻与学业成绩:系统回顾与元分析》。
IF 24.7 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-07 DOI: 10.1001/jamapediatrics.2024.3674
Olsen Chan, Ahad Daudi, David Ji, Mathias Wang, Jeremy P Steen, Parsia Parnian, Crystal Li, Annie Xiong, Wei Zhang, Luciane C Lopes, James MacKillop, Jason W Busse, Li Wang

Importance: Cannabis use during adolescence and young adulthood may affect academic achievement; however, the magnitude of association remains unclear.

Objective: To conduct a systematic review evaluating the association between cannabis use and academic performance.

Data sources: CINAHL, EMBASE, MEDLINE, PsycInfo, PubMed, Scopus, and Web of Science from inception to November 10, 2023.

Study selection: Observational studies examining the association of cannabis use with academic outcomes were selected. The literature search identified 17 622 unique citations.

Data extraction and synthesis: Pairs of reviewers independently assessed risk of bias and extracted data. Both random-effects models and fixed-effects models were used for meta-analyses, and the Grading of Recommendations Assessment, Development, and Evaluation approach was applied to evaluate the certainty of evidence for each outcome. Data were analyzed from April 6 to May 25, 2024.

Main outcomes and measures: School grades, school dropout, school absenteeism, grade retention, high school completion, university enrollment, postsecondary degree attainment, and unemployment.

Results: Sixty-three studies including 438 329 individuals proved eligible for analysis. Moderate-certainty evidence showed cannabis use during adolescence and young adulthood was probably associated with lower school grades (odds ratio [OR], 0.61 [95% CI, 0.52-0.71] for grade B and above); less likelihood of high school completion (OR, 0.50 [95% CI, 0.33-0.76]), university enrollment (OR, 0.72 [95% CI, 0.60-0.87]), and postsecondary degree attainment (OR, 0.69 [95% CI, 0.62-0.77]); and increased school dropout rate (OR, 2.19 [95% CI, 1.73-2.78]) and school absenteeism (OR, 2.31 [95% CI, 1.76-3.03]). Absolute risk effects ranged from 7% to 14%. Low-certainty evidence suggested that cannabis use may be associated with increased unemployment (OR, 1.50 [95% CI, 1.15-1.96]), with an absolute risk increase of 9%. Subgroup analyses with moderate credibility showed worse academic outcomes for frequent cannabis users and for students who began cannabis use earlier.

Conclusions and relevance: Cannabis use during adolescence and young adulthood was probably associated with increases in school absenteeism and dropout; reduced likelihood of obtaining high academic grades, graduating high school, enrolling in university, and postsecondary degree attainment; and perhaps increased unemployment. Further research is needed to identify interventions and policies that mitigate upstream and downstream factors associated with early cannabis exposure.

重要性:青春期和青年期吸食大麻可能会影响学业成绩;但两者之间的关联程度仍不清楚:对吸食大麻与学习成绩之间的关系进行系统性评估:数据来源:CINAHL、EMBASE、MEDLINE、PsycInfo、PubMed、Scopus 和 Web of Science(从开始到 2023 年 11 月 10 日):研究选择:研究大麻使用与学习成绩关系的观察性研究。文献检索发现了 17 622 条独特的引文:一对审稿人独立评估偏倚风险并提取数据。采用随机效应模型和固定效应模型进行荟萃分析,并采用 "建议分级评估、发展和评价 "法对每项结果的证据确定性进行评估。数据分析时间为 2024 年 4 月 6 日至 5 月 25 日:学校成绩、辍学率、旷课率、年级保持率、高中毕业率、大学入学率、中学后学位获得率和失业率:有 63 项研究(包括 438 329 人)符合分析条件。中度确定性证据显示,青春期和青年期吸食大麻可能与学校成绩较差有关(B 级及以上的几率比 [OR],0.61 [95% CI,0.52-0.71]);完成高中学业的可能性较低(OR,0.50[95%CI,0.33-0.76])、大学入学率(OR,0.72[95%CI,0.60-0.87])和中学后学位获得率(OR,0.69[95%CI,0.62-0.77]);辍学率(OR,2.19[95%CI,1.73-2.78])和旷课率(OR,2.31[95%CI,1.76-3.03])增加。绝对风险效应从 7% 到 14% 不等。低确定性证据表明,吸食大麻可能与失业率上升有关(OR,1.50 [95% CI,1.15-1.96]),绝对风险增加 9%。可信度中等的分组分析显示,经常吸食大麻的学生和较早开始吸食大麻的学生的学习成绩较差:青春期和青年期吸食大麻可能与以下情况有关:旷课和辍学率上升;获得高学业成绩、高中毕业、进入大学和获得中学后学位的可能性降低;以及失业率可能上升。需要开展进一步研究,以确定可减轻与早期接触大麻有关的上游和下游因素的干预措施和政策。
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引用次数: 0
When Biological Causality Is Determined in a Court of Law. 当生物因果关系在法庭上确定时。
IF 24.7 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-07 DOI: 10.1001/jamapediatrics.2024.4012
Josef Neu, Neena Modi
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引用次数: 0
Early Childhood Screen Use Contexts and Cognitive and Psychosocial Outcomes: A Systematic Review and Meta-analysis. 儿童早期屏幕使用环境与认知和社会心理结果:系统回顾与元分析》。
IF 24.7 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-01 DOI: 10.1001/jamapediatrics.2024.2620
Sumudu Mallawaarachchi, Jade Burley, Myrto Mavilidi, Steven J Howard, Leon Straker, Lisa Kervin, Sally Staton, Nicole Hayes, Amanda Machell, Marina Torjinski, Brodie Brady, George Thomas, Sharon Horwood, Sonia L J White, Juliana Zabatiero, Clara Rivera, Dylan Cliff

Importance: The multifaceted nature of screen use has been largely overlooked in favor of a simplistic unidimensional measure of overall screen time when evaluating the benefits and risks of screen use to early childhood development.

Objective: To conduct a systematic review and meta-analysis to examine associations of screen use contexts in early childhood with cognitive and psychosocial outcomes.

Data sources: PsycINFO, Embase, MEDLINE Ovid, ProQuest, CINAHL, Web of Science, and Scopus were searched from inception to December 31, 2023.

Study selection: A total of 7441 studies were initially identified. Studies were included if they examined associations between a contextual factor of screen use among children aged 0 to 5.99 years and cognitive or psychosocial development. Observational, experimental, and randomized clinical trial study designs were included.

Data extraction and synthesis: All studies were independently screened in duplicate following PRISMA guidelines. Effect sizes of associations (r) from observational studies were pooled using random-effects 3-level meta-analyses. The remaining study designs were narratively synthesized.

Main outcomes and measures: Screen use contexts included content (child directed and age inappropriate), type (program viewing and game or app use), co-use (or solo use), background television, caregiver screen use during child routines, and purpose. Outcomes were cognitive (executive functioning, language, and academic skills) or psychosocial (internalizing and externalizing behavior problems and socioemotional competence).

Results: Overall, 100 studies (176 742 participants) were included, and of these, 64 observational studies (pooled sample sizes ranging from 711 to 69 232) were included in meta-analyses. Program viewing (n = 14; k = 48; r, -0.16; 95% CI, -0.24 to -0.08) and background television (n = 8; k = 18; r, -0.10; 95% CI, -0.18 to -0.02) were negatively associated with cognitive outcomes, while program viewing (n = 6; k = 31; r, -0.04; 95% CI, -0.07 to -0.01), age-inappropriate content (n = 9; k = 36; r, -0.11; 95% CI, -0.17 to -0.04), and caregiver screen use during routines (n = 6; k = 14; r, -0.11; 95% CI, -0.20 to -0.03) were negatively associated with psychosocial outcomes. Co-use was positively associated with cognitive outcomes (n = 8; k = 28; r, 0.14; 95% CI, 0.03 to 0.25).

Conclusions and relevance: Findings show small to moderate effect sizes that highlight the need to consider screen use contexts when making recommendations for families, clinicians, and educators beyond screen time limits; including encouraging intentional and productive screen use, age-appropriate content, and co-use with caregivers.

重要性:在评估屏幕使用对儿童早期发展的益处和风险时,屏幕使用的多面性在很大程度上被忽视了,而只是简单地从单一维度衡量总体屏幕使用时间:进行系统回顾和荟萃分析,研究儿童早期使用屏幕的情况与认知和社会心理结果之间的关联:数据来源:检索了从开始到 2023 年 12 月 31 日的 PsycINFO、Embase、MEDLINE Ovid、ProQuest、CINAHL、Web of Science 和 Scopus:最初共确定了 7441 项研究。只要研究了 0 至 5.99 岁儿童使用屏幕的环境因素与认知或社会心理发展之间的关系,均被纳入研究范围。数据提取和综合:所有研究均按照 PRISMA 指南进行了独立的重复筛选。观察性研究的关联效应大小(r)采用随机效应三级荟萃分析法进行汇总。对其余研究设计进行了叙述性综合:屏幕使用情境包括内容(针对儿童和与年龄不符)、类型(观看节目和使用游戏或应用程序)、共同使用(或单独使用)、背景电视、照顾者在儿童例行活动中使用屏幕以及目的。研究结果包括认知(执行功能、语言和学习技能)或社会心理(内化和外化行为问题以及社会情感能力):共有 100 项研究(176 742 名参与者)被纳入荟萃分析,其中 64 项观察性研究(汇总样本量从 711 到 69 232 不等)被纳入荟萃分析。节目观看(n = 14;k = 48;r,-0.16;95% CI,-0.24 至 -0.08)和背景电视(n = 8;k = 18;r,-0.10;95% CI,-0.18 至 -0.02)与认知结果呈负相关,而节目观看(n = 6;k = 31;r,-0.04; 95% CI, -0.07 to -0.01)、与年龄不符的内容(n = 9; k = 36; r, -0.11; 95% CI, -0.17 to -0.04)以及照顾者在例行活动中使用屏幕(n = 6; k = 14; r, -0.11; 95% CI, -0.20 to -0.03)与心理社会结果呈负相关。共同使用与认知结果呈正相关(n = 8;k = 28;r,0.14;95% CI,0.03 至 0.25):研究结果显示了小到中等的效应大小,突出表明在向家庭、临床医生和教育工作者提出屏幕使用时间限制以外的建议时,需要考虑屏幕使用的背景;包括鼓励有意和有效地使用屏幕、适合年龄的内容以及与照顾者共同使用屏幕。
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引用次数: 0
Disaggregated Suicide Mortality Rates Among Asian American Youths and Young Adults by Ethnic Subgroup. 按族裔亚群分列的亚裔美国青少年自杀死亡率。
IF 24.7 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-01 DOI: 10.1001/jamapediatrics.2024.2686
Anthony L Bui, Isaac C Rhew, Frederick P Rivara, Tumaini R Coker
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引用次数: 0
Transgender Adolescent School Climate, Mental Health, and Adult Social Support. 变性青少年的校园环境、心理健康和成人社会支持。
IF 24.7 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-01 DOI: 10.1001/jamapediatrics.2024.3079
Mollie T McQuillan, Joseph R Cimpian, Benjamin A Lebovitz, Erin K Gill
{"title":"Transgender Adolescent School Climate, Mental Health, and Adult Social Support.","authors":"Mollie T McQuillan, Joseph R Cimpian, Benjamin A Lebovitz, Erin K Gill","doi":"10.1001/jamapediatrics.2024.3079","DOIUrl":"10.1001/jamapediatrics.2024.3079","url":null,"abstract":"","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":" ","pages":"1082-1084"},"PeriodicalIF":24.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11348082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Circulating Biomarkers of Language Development in Single Ventricle Heart Disease. 单心室心脏病患者语言发育的早期循环生物标志物
IF 24.7 1区 医学 Q1 PEDIATRICS Pub Date : 2024-10-01 DOI: 10.1001/jamapediatrics.2024.2507
Kelly R Wolfe, Lindsay M Thomson, Sierra Niemiec, Christopher A Mancuso, Ludmila Khailova, Benjamin S Frank, Jesse A Davidson
{"title":"Early Circulating Biomarkers of Language Development in Single Ventricle Heart Disease.","authors":"Kelly R Wolfe, Lindsay M Thomson, Sierra Niemiec, Christopher A Mancuso, Ludmila Khailova, Benjamin S Frank, Jesse A Davidson","doi":"10.1001/jamapediatrics.2024.2507","DOIUrl":"10.1001/jamapediatrics.2024.2507","url":null,"abstract":"","PeriodicalId":14683,"journal":{"name":"JAMA Pediatrics","volume":" ","pages":"1072-1074"},"PeriodicalIF":24.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
JAMA Pediatrics
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