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Protective Effect of Aerobic Training with Blue-Algae spirulina Supplementation on Endothelial Dysfunction and Insulin Resistance in Overweight Adults Men 有氧训练加蓝藻螺旋藻对超重成年男性内皮功能障碍和胰岛素抵抗的保护作用
Pub Date : 2022-03-01 DOI: 10.52547/jorjanibiomedj.10.1.26
Ammar Raoufi Sangachin, Ahmad Abdi, A. Barari
Background and Objective : Aging is the major risk factor for the development of cardiovascular diseases as aging increases plasma levels of pro-inflammatory mediators and endothelial dysfunction. Physical exercise and spirulina improve the endothelial dysfunction and chronic inflammation that accompanies aging. This study aimed to evaluate the effects of Aerobic Exercise (AT), with blue-algae Spirulina Supplementation (SP) on the indicators of endothelial dysfunction and insulin resistance in overweight adult men. Material and Methods: In this clinical trial study, 40 overweight adult men (age 57.50±4.84 years, Body mass index: BMI 26.90±2.85 kg/m2) were selected from Bandar-e-Anzali and randomly allocated into five groups; including Control-Normal (CN), Overweight (OW), Overweight-Aerobic Training (OWAT), Overweight-Spirulina (OWSP) and Overweight-Aerobic Training -Spirulina (OWATSP). Training groups participated in an aerobic exercise program for eight weeks, five sessions per week (with an intensity of 65 to 85% of peak heart rate, 40 minutes). The OWSP and OWATSP groups were provided with two 500 mg SP tablets daily in the morning and evening. Data were analyzed using an independent t-test and ANCOVA at a significance level of P <0.05. Results: The levels of endothelin-1(ET-1), Intercellular Adhesion Molecule 1 (ICAM-1), Selectin-E, and HOMA-IR index in the OW group were higher than CN ( P ≤0.05). AT and SP significantly reduced ET-1, ICAM-1, Selectin-E, and HOMA-IR ( P ≤0.05). In the OWATSP group, the levels of ET-1, ICAM-1, Selectin-E, and HOMA-IR were significantly lower than OW and OWSP ( P ≤0.05). NO levels significantly decreased in OWATSP and OWAT ( P ≤0.05). Conclusion: Aerobic training and spirulina supplementation could improve the endothelial function in overweight adult men, by altering the levels of ET-1, ICAM-1, Selectin-E, and NO. However, the simultaneous effect of AT with SP on these indices was better. Improved endothelial function was associated with an improvement in insulin resistance index.
背景与目的:衰老是心血管疾病发生的主要危险因素,因为衰老会增加血浆中促炎介质的水平和内皮功能障碍。体育锻炼和螺旋藻可以改善内皮功能障碍和伴随衰老的慢性炎症。本研究旨在评价有氧运动(AT)加蓝藻螺旋藻(SP)对超重成年男性内皮功能障碍和胰岛素抵抗指标的影响。材料与方法:在本临床试验研究中,从安扎利港选取40名超重成年男性(年龄57.50±4.84岁,体重指数:BMI 26.90±2.85 kg/m2),随机分为5组;包括控制正常(CN)、超重(OW)、超重有氧训练(OWAT)、超重螺旋藻(OWSP)和超重有氧训练-螺旋藻(OWATSP)。训练组参加为期八周的有氧运动计划,每周五次(强度为峰值心率的65%至85%,40分钟)。OWSP组和OWATSP组每天早晚各给予SP片500 mg。数据分析采用独立t检验和ANCOVA,显著性水平P <0.05。结果:OW组内皮素-1(ET-1)、细胞间粘附分子1(ICAM-1)、选择素- e水平及HOMA-IR指数均高于CN组(P≤0.05)。AT和SP显著降低ET-1、ICAM-1、selection - e和HOMA-IR (P≤0.05)。OWATSP组ET-1、ICAM-1、selection - e、HOMA-IR水平均显著低于OW和OWSP组(P≤0.05)。OWATSP、OWAT组NO水平均显著降低(P≤0.05)。结论:有氧训练和补充螺旋藻可以通过改变ET-1、ICAM-1、select - e和NO的水平来改善超重成年男性的内皮功能。但AT与SP同时施用对这些指标的影响较好。内皮功能的改善与胰岛素抵抗指数的改善相关。
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引用次数: 0
The Communication Style of the Elderly during COVID-19 Pandemic COVID-19大流行期间老年人的沟通方式
Pub Date : 2022-03-01 DOI: 10.52547/jorjanibiomedj.10.1.37
Nasrin Kheibar, Hossein Nasiri
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引用次数: 0
Assessment of Health-promoting Lifestyle among Medical Students of Mashhad University of Medical Sciences in 2018-2019 2018-2019年马什哈德医科大学医学生促进健康生活方式评估
Pub Date : 2022-03-01 DOI: 10.52547/jorjanibiomedj.10.1.4
Nafiseh Mousavi Bazaz, M. Haghighi, Roya Boujaran, Vida Vakili, mojtaba mousavi bazzaz, Gholamreza Haghighi
Background and Objective : Young adults, especially the students of medical fields, as the health ambassadors of every community, play a vital role in health maintenance and improvement of society. Promoting the lifestyle behaviors of this group leads to the better health status of other society members. This study was set to assess the Health-Promoting Lifestyle (HPL) of medical students in Mashhad, Iran. Material and Methods: This descriptive cross-sectional study was performed on 120 medical students of Mashhad University of Medical Sciences in 2018-2019. The data were collected by the self-reported Persian version of HPL profile II which has been validated in former studies. SPSS package (version 20) was used to analyze data, and two independent samples t-test to compare data sampling was done in two stages, including random selection of the classroom and the clinical ward, and then random selection of students in each. Results: 50.2% of all participants were male in gender and 77.5% were single. The overall score of HPL profile II among all the participants was moderate. According to the scores of Health-promoting Lifestyle Behaviors (HPLB), stress management scored the highest (29.62±4.45), spiritual growth, and physical activity was at the lowest levels (10.84±2.07 and 16.55±4.97, respectively). Two dimensions of HPLB showed a significant difference based on the gender of the participants (better physical activity in men (p-value= 0.04) and self-responsibility for health in women (p-value=0.05)). There was not a statistical difference between HPL subscales by the participants` marital status. Conclusion: The HPL profile II total score is moderate, but not desirable; therefore, admitting appropriate programs for lifestyle improvement, especially in the field of mental development, physical activities, and nutrition, regarding student gender, is recommended. Our findings can attribute the health policymakers to developing health programs among the students and adding related courses to the educational curriculum.
背景与目的:青年人,特别是医学专业的学生,作为各个社区的健康大使,在维护和改善社会健康方面发挥着至关重要的作用。促进这一群体的生活方式行为会导致其他社会成员的健康状况改善。本研究旨在评估伊朗马什哈德医科学生的健康促进生活方式(HPL)。材料与方法:本描述性横断面研究于2018-2019年对马什哈德医科大学120名医学生进行。数据收集自自报告的波斯语版HPL档案II,已在以前的研究中得到验证。采用SPSS软件包(version 20)对数据进行分析,采用两个独立样本t检验进行数据抽样比较,分为随机选取课堂和临床病房两个阶段,然后随机选取每个阶段的学生。结果:50.2%的参与者性别为男性,77.5%为单身。所有参与者的HPL概况II总体得分为中等。健康促进生活方式(HPLB)得分中,压力管理得分最高(29.62±4.45分),精神成长得分最低(10.84±2.07分),体力活动得分最低(16.55±4.97分)。HPLB的两个维度根据参与者的性别(男性更好的身体活动(p值= 0.04)和女性对健康的自我责任(p值=0.05))显示显着差异。参与者的婚姻状况对HPL各分量表的影响无统计学差异。结论:HPL剖面II总分适中,但不理想;因此,建议接受适当的生活方式改善方案,特别是在心理发展、体育活动和营养方面,考虑到学生的性别。我们的研究结果可以将健康政策制定者归因于在学生中开展健康计划并在教育课程中增加相关课程。
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引用次数: 0
Effects of Propolis and Persica Mouthwashes on Minor Aphthous Ulcers: A Comparative Study 蜂胶漱口水与桃胶漱口水治疗轻微口腔溃疡的比较研究
Pub Date : 2022-03-01 DOI: 10.52547/jorjanibiomedj.10.1.56
M. Alemrajabi, Maryam-Sadat Sadrzadeh-Afshar, Mahdi Dastorani, Meysam Barjestehnia
Background and objectives: Recurrent Aphthous Stomatitis (RAS) is a common disease of the nonkeratinized oral mucosa characterized by painful ulcerations and inflammation, causing difficulty in eating, swallowing, and speaking. Symptomatic treatment is considered for this disease due to the ambiguity of the exact etiology. The beneficial therapeutic effects of Persica and Propolis mouthwashes led us to the objective of studying therapeutic potentials of these herbal mouthwashes. Material and Methods: The present double-blind clinical trial was conducted on 40 patients with minor aphthous ulcers and no systemic disease, who were divided into two groups of 20 via random allocation (systematic random sampling). Each group received 15 drops of propolis or persica mouthwashes three times a day for 10 days. Pain intensity was recorded by measuring the score of Visual Analogue Scale (VAS) and the diameter of minor aphthous lesions (in mm) at three periods of before treatment, and on the second and sixth days after treatment. Data were analyzed by Mann-Whitney test. Results: There was no significant difference between pain intensity and ulcer size before treatment and on the second day of treatment. The pain intensity on day 6 was significantly lower in Persica group (P=0.045) but no difference was observed in the mean ulcer size on day 6 between the two groups (P=0.104). The rate of pain relief (P=0.031) and reduction of ulcer size (P=0.046) were significantly higher in Persica group. Conclusion: Propolis and Persica mouthwashes both reduce pain intensity and ulcer size in minor aphthous ulcers, and Persica showed a stronger potential to achieve these goals compared to propolis.
背景和目的:复发性口腔炎(RAS)是一种常见的非角化口腔黏膜疾病,其特征是疼痛性溃疡和炎症,导致进食、吞咽和说话困难。由于病因不明,本病应考虑对症治疗。桃胶和蜂胶漱口水的有益治疗效果使我们对这些草药漱口水的治疗潜力进行了研究。材料与方法:本双盲临床试验选取40例无全身性疾病的轻度阿弗顿溃疡患者,采用随机分配(系统随机抽样)方式分为两组,每组20例。每组给予15滴蜂胶或桃胶漱口水,每天3次,连续10天。分别于治疗前三期、治疗后第2天、第6天采用视觉模拟量表(VAS)评分和小口疮病灶直径(mm)记录疼痛强度。数据分析采用Mann-Whitney检验。结果:治疗前与治疗第2天疼痛强度、溃疡大小差异无统计学意义。在第6天疼痛强度上,百思果组明显低于对照组(P=0.045),但在第6天溃疡平均大小上,两组差异无统计学意义(P=0.104)。百思果组疼痛缓解率(P=0.031)和溃疡缩小率(P=0.046)显著高于对照组。结论:蜂胶漱口水和桃胶漱口水均可减轻轻微口腔溃疡患者的疼痛强度和溃疡大小,且桃胶漱口水比蜂胶漱口水更有可能达到这些目标。
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引用次数: 0
Vitamin A and Viral Infection in Critical Care 重症监护中的维生素A与病毒感染
Pub Date : 2022-03-01 DOI: 10.52547/jorjanibiomedj.10.1.67
Emad Behboudi, Parisa Zeynali, Niloofar Zahedian Nezhad, Vahideh Hamidi Sofiani
Vitamin A is fat-soluble compounds of retinoid derivate, consisting of retinol, retinal, and retinyl esters. Vitamin A also affects cell growth and differentiation, playing a critical role in the normal formation and function of the heart, lungs, kidneys, and other organs. According to the role of vitamin A in enhancing immune function, it is known as an anti-inflammatory agent. Also, vitamin A supplementation by reducing morbidity and mortality in different infectious diseases, such as measles, diarrheal disease, measles-related pneumonia, human immunodeficiency virus infection, and malaria considered as a crucial factor against infection. So vitamin A deficiency can be life-threatening, because of impairing the response to infection and significant risk of development of severe respiratory infections in infants and young children. In this paper, we have discussed the effects of vitamin A in modulating immune responses in viral infections and the direct effects of this vitamin on viral replication by comparing its role during different types of viral infections.
维生素A是类视黄醇衍生物的脂溶性化合物,由视黄醇、视网膜和视黄醇酯组成。维生素A还影响细胞的生长和分化,在心脏、肺、肾脏和其他器官的正常形成和功能中起着至关重要的作用。根据维生素A在增强免疫功能方面的作用,它被称为抗炎剂。此外,通过减少不同传染病的发病率和死亡率来补充维生素A,例如麻疹、腹泻病、麻疹相关肺炎、人类免疫缺陷病毒感染和疟疾被认为是防止感染的关键因素。因此,缺乏维生素A可能会危及生命,因为它会损害婴儿和幼儿对感染的反应,并有很大的风险患上严重的呼吸道感染。本文通过比较维生素A在不同类型病毒感染中的作用,讨论了维生素A在病毒感染中调节免疫反应的作用,以及维生素A对病毒复制的直接影响。
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引用次数: 0
Adenosine Receptor Signaling in Diseases with Focus on Cancer 腺苷受体信号在以癌症为重点的疾病中的作用
Pub Date : 2022-03-01 DOI: 10.52547/jorjanibiomedj.10.1.41
Mahmood Poorjam, Zeinabsadat Mohammadi, S. Jafari
Various investigation has shown the magnitude role of adenosine receptors in cancer development. The A1, A2A, A2B, and A3 G-protein-coupled cell surface Adenosine Receptors (ARs) are found to be upregulated in many types of cancers. The adenosine receptor function has been affected by specific ligands such as agonists and/or antagonists regulated cancer (Neoplasms) cells proliferation via signaling pathways. Adenosine not only is an important intermediate metabolite but also acts as the essential ligand of adenosine receptors in physiological and pathological conditions. Furthermore, many studies have shown that adenosine receptors expression has increased in many types of cancer. In this review, we first describe adenosine's role in physiological condition and in cancer development. We further, discuss the type of adenosine receptors, distribution, expression, and their roles in cancer.
各种研究表明腺苷受体在癌症发展中的重要作用。A1, A2A, A2B和A3 g蛋白偶联的细胞表面腺苷受体(ARs)在许多类型的癌症中被发现上调。腺苷受体的功能受到特定配体(如激动剂和/或拮抗剂)的影响,这些配体通过信号通路调节肿瘤细胞的增殖。腺苷不仅是一种重要的中间代谢物,而且在生理和病理条件下都是腺苷受体必不可少的配体。此外,许多研究表明腺苷受体的表达在许多类型的癌症中都有所增加。在这篇综述中,我们首先描述了腺苷在生理状态和癌症发展中的作用。我们进一步讨论了腺苷受体的类型、分布、表达及其在癌症中的作用。
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引用次数: 2
The Effect of Magnification for Detecting Low and High Internal Root Resorption in Single-Root Teeth in Cone-Beam Computed Tomography (an in Vitro Study) 锥形束计算机断层扫描中放大倍数检测单根牙内根吸收高低的效果(体外研究)
Pub Date : 2021-12-01 DOI: 10.52547/jorjanibiomedj.9.4.22
Ali Habibi Kia, A. dabaghi, Pouya Nikdast
1. Assistant Professor of Oral and Maxillofacial Radiology, Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 2. Associate Professor of Oral and Maxillofacial Radiology, Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 3. Undergraduate Student of Dentistry,Faculty of Dentistry, Ahvaz Jundishapur University of Medical Sciences. Ahvaz, Iran
1. 伊朗阿瓦士Jundishapur医科大学牙科学院口腔颌面放射学系口腔颌面放射学助理教授2 .伊朗阿瓦士Jundishapur医科大学牙科学院口腔颌面放射学系口腔颌面放射学副教授阿瓦士君迪沙普尔医科大学牙科学院牙科专业本科生。阿瓦士,伊朗
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引用次数: 0
Evaluation of Relationship between the Children’s Dental Fear with the Parental State-Trait Anxiety 儿童牙科恐惧与父母状态-特质焦虑的关系评价
Pub Date : 2021-12-01 DOI: 10.52547/jorjanibiomedj.9.4.65
Z. Bahrololoomi, Tahereh Sadeghieh, nahid maghsoodi, Shirin Pajouhandeh
1. Department of Pediatric Dentistry, Social Determinants of Oral Health Research Center, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 2. Child and Adolescent Psychiatrist, Researcher of Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 3. Postgraduate Student, Department of Pediatric Dentistry, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 4. Postgraduate Student, Department of Pediatric Dentistry, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
1. Shahid Sadoughi医科大学牙科学院口腔健康的社会决定因素研究中心,儿童牙科学系,Yazd,伊朗儿童和青少年精神病学家,成瘾和行为科学中心研究员,Shahid Sadoughi医学科学大学,亚兹德,伊朗Shahid Sadoughi医科大学牙科学院儿科牙科学系研究生,伊朗亚兹德伊朗亚兹德Shahid Sadoughi医科大学牙科学院儿科牙科学系研究生
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引用次数: 0
Job Motivation and the Influential Factors in Hospital Staff of Golestan University of Medical Sciences, Iran (2016) 伊朗戈列斯坦医科大学医院工作人员工作动机及影响因素分析(2016)
Pub Date : 2021-12-01 DOI: 10.52547/jorjanibiomedj.9.4.55
G. Roohi, G. Mahmoodi-Shan
Material and Methods: This cross-sectional study was performed on 367 hospital staff of Golestan University of Medical Sciences in 2016 during nine months. The participants were selected via stratified sampling and simple random sampling using the standard situational motivation scale (SIMS) and Lawrence Lindal motivational priorities. Data analysis was performed in SPSS version 20 using descriptive and analytical statistics.
材料与方法:本横断面研究于2016年对戈列斯坦医科大学367名医院工作人员进行了为期9个月的研究。采用标准情境动机量表(SIMS)和Lawrence Lindal动机优先级,通过分层抽样和简单随机抽样的方法对被试进行选择。使用SPSS version 20进行数据分析,采用描述性统计和分析性统计。
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引用次数: 0
Impact of Quercetin on Sperm Parameters, Testicular Tissue and Sex Hormone: a Systematic Review 槲皮素对精子参数、睾丸组织和性激素的影响:系统综述
Pub Date : 2021-12-01 DOI: 10.52547/jorjanibiomedj.9.4.33
F. Hosseinabadi, T. Faraji, M. Malmir
Material and Methods: Electronic search with MeSH words including Quercetin, Infertility, Sperm, Testicular tissue, and Sex hormones was accomplished in databases Web of Science, Scopus, Science Direct, Wiley, NCBI, and Google Scholar. Finally, 296 articles were recognized during the primary search. A total of 144 papers, passing the analysis stage containing Identification, Screening, and Eligibility were selected for assessment.
材料和方法:在Web of Science、Scopus、Science Direct、Wiley、NCBI和Google Scholar等数据库中进行电子检索,检索词包括槲皮素、不育、精子、睾丸组织和性激素。最终,在初级检索中识别出296篇文章。通过鉴定、筛选和合格三个分析阶段,共筛选出144篇论文进行评估。
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引用次数: 0
期刊
Jorjani Biomedicine Journal
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