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The evaluation of mandibular canal visibility on cone beam computed tomography (CBCT) images: A cross-sectional study 锥形束计算机断层扫描(CBCT)对下颌管可见性的评价:一项横断面研究
Pub Date : 2019-09-10 DOI: 10.29252/jorjanibiomedj.7.3.56
S. H. Razavi, Soudeh Berahmand, Khalil Sarikhani Khorami, Motahareh Kaboodsaz Yazdi, N. Namiranian
soudeh.b92@gmail.com Abstract Background and objectives: An effective factor in choosing the correct place for the dental implant and performing surgical procedures in the posterior regions of mandible is the position of the mandibular canal. Failure to consider this important landmark will damage the inferior alveolar nerve. Considering the widespread use of implants and the precision of the images obtained from CBCT. The aim of this study was to evaluate the rate of visibility of mandibular canal by CBCT in order to prevent damage to the inferior alveolar nerves and arteries. Methods: In this study, 90 archived CBCT images of patients from a private center of oral and maxillofacial radiology in Yazd that was taken by technician was evaluated during 2012-2019. The visibility of the mandibular canal in reconstructed panoramic images of CBCT was assessed by a dentistry student trained by the maxillofacial radiologist in five areas in different thicknesses on each side. Data were analyzed using SPSS 17 software. Chi-square, and correlation coefficient were done. Results: In total, in 53.38% of CBCT images both borders of mandibular canal were visible, in 17.95%, only one border was visible (difficult observation) and in 28.7% of cases, lack of visibility of mandibular canal was reported. There was no significant difference between sex, age, side and thickness in mandibular canal visibility (P >0.05). Conclusion: In more than half of CBCT images, both borders were clearly visible in both right and left sides; therefore we can conclude that CBCT is a useful tool for the observation of mandibular canal before surgeries.
soudeh.b92@gmail.com摘要背景与目的:下颌根管的位置是下颌后区选择种植牙的正确位置和进行手术的一个有效因素。不考虑这个重要的标志将损害下肺泡神经。考虑到植入物的广泛使用和从CBCT获得的图像精度。本研究的目的是评估CBCT对下颌管的可见率,以防止对下牙槽神经和动脉的损害。方法:在本研究中,对亚兹德一家私立口腔颌面放射中心2012-2019年由技术人员拍摄的90张患者CBCT图像进行评估。在重建的CBCT全景图像中,下颌管的可见性由一名接受过颌面放射科医师培训的牙科学生在每侧不同厚度的五个区域进行评估。数据分析采用SPSS 17软件。卡方检验和相关系数分析。结果:53.38%的CBCT图像显示下颌管双边界,17.95%的CBCT图像仅显示一侧边界(观察困难),28.7%的CBCT图像显示下颌管不可见。不同性别、年龄、侧边、厚度的患者下颌管可见性差异无统计学意义(P < 0.05)。结论:半数以上的CBCT图像左右两侧边界清晰可见;因此,我们可以得出结论,CBCT是术前观察下颌管的有效工具。
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引用次数: 1
Tumorigenicity of Esophageal Cancer Stem Cells (ECSCs) in nude mouse xenograft model 食管癌干细胞(ECSCs)在裸鼠异种移植模型中的致瘤性
Pub Date : 2019-09-10 DOI: 10.29252/jorjanibiomedj.7.3.4
Ayyoob Khosravi, Fariba Kokabi, R. Behzadi, J. Asadi
Jahanbakhsh Asadi, Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran dr.asadi@goums.ac.ir Abstract Background and objectives: Modeling cancer in vivo is a very important tool to investigate cancer pathogenesis and molecular mechanisms involved in cancer progression. Laboratory mice are the most common animal used for rebuilding human cancer in vivo. Cancer stem cells (CSCs) are the main reason of failure in cancer therapy because of tumor relapse and metastasis. Isolation of cancer stem cells helps us to study their function and behavior. In the current study we separate cancer stem-like cells using sphere formation assay then investigate their tumorigenicity in xenograft tumor model. Methods: YM1 cancer cells were cultured in serum-free media (SFM) in low adherent culture dishes for enrichment of cancer stem cells. The resulting spheres containing cancer stem-like cells were dissociated into single cells and were injected into the dorsal flank of B6 nude mice. Results: A few days after injection, subcutaneous tumors formed. The growth curves of the resulting tumors were plotted using their weekly recorded lengths. The tumors' volume and weight were measured. The size of resulting tumors was appropriate to the number of cells injected. Pathological analysis confirmed esophageal origin of the resulting tumors. Conclusion: Using laboratory mice models is a practical modeling system that provides us investigation of human tumors pathogenesis in vivo.
Jahanbakhsh Asadi, Golestan医科大学代谢紊乱研究中心,Gorgan,伊朗dr.asadi@goums.ac.ir摘要背景和目的:体内癌症建模是研究癌症发病机制和参与癌症进展的分子机制的重要工具。实验小鼠是在体内重建人类癌症最常用的动物。肿瘤干细胞(Cancer stem cells, CSCs)是肿瘤复发和转移导致治疗失败的主要原因。分离癌症干细胞有助于我们研究它们的功能和行为。在本研究中,我们使用球形成法分离肿瘤干细胞,然后在异种移植肿瘤模型中研究其致瘤性。方法:采用低贴壁培养皿无血清培养基(SFM)培养YM1癌细胞,富集肿瘤干细胞。将含有肿瘤干细胞样细胞的球体分离成单细胞,并注射到B6裸鼠背侧。结果:注射后数日皮下形成肿瘤。用每周记录的肿瘤长度绘制肿瘤的生长曲线。测量肿瘤的体积和重量。所产生的肿瘤大小与注射的细胞数量相适应。病理分析证实肿瘤起源于食道。结论:实验室小鼠模型为研究人类肿瘤的体内发病机制提供了一种实用的建模系统。
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引用次数: 1
National Food and Nutrition Security System (SAMAT), A Tool for Identifying and Monitoring Food Insecurity in the Country 国家粮食和营养安全系统(SAMAT):识别和监测国家粮食不安全状况的工具
Pub Date : 2019-09-10 DOI: 10.29252/jorjanibiomedj.7.3.24
M. Gholami, Majid Najafzadeh, N. Behnampour, Z. Abdollahi, F. S. Ghotbabadi, F. Lashkarboluki, M. Honarvar
Mohammad Reza Honarvar, Health Management and Social Development research Center, Golestan University of Medical Sciences, Gorgan, Iran mrhonarvar@goums.ac.ir Abstract Background and objectives: Iran was reported in the high-risk group of World Food Security Map in 2008 .Identifying food insecurity is first step for executing interventions. Measuring household food security is its cornerstone. SAMAT System was designed to provide a variety of GIS-based reports to policy makers and managers in the field of food security. Methods: SAMAT system was developed by a team working with various specialties. The system was analyzed using Rational Unified Process methodology and after optimization and normalization process, centralized database was formed. SQL Server 2014 software was used for its implementation. SharpMap open source engine was used to render spatial data and display maps on the web, and many parts of the engine were coded specifically to meet different organizational needs. The system was designed using the WEB GIS engine. Results: SAMAT system was executed in nine provinces of the country in different periods. SAMAT dashboard provides a variety of information for executive managers. Based on demographic data, the state of food insecurity can be identified at different levels from city to village, in a variety of graphs. A spectrum from the urban distribution to the local distribution of food insecurity can be identified on the GIS map. Zooming in on different areas can help to identify more food insecure neighborhoods within the village or town, thus giving managers the priority of food insecurity interventions at the neighborhood or village level. One can view household characteristics and the results of questionnaire information. Conclusion: AMAT system can be useful for managing food security at the national, provincial, city and even rural or urban levels. we recommend periodically prioritizing points, Identifying the provinces and re-evaluating the effectiveness of interventions through the SAMAT-based system after comprehensive implementation of food insecurity reduction
背景与目的:伊朗在2008年被报告为世界粮食安全地图的高风险群体。确定粮食不安全是执行干预措施的第一步。衡量家庭粮食安全是其基石。SAMAT系统旨在向粮食安全领域的决策者和管理人员提供各种基于地理信息系统的报告。方法:SAMAT系统由各专业人员共同开发。采用Rational Unified Process方法对系统进行分析,经过优化和规范化处理,形成集中的数据库。采用SQL Server 2014软件实现。使用SharpMap开源引擎在网络上呈现空间数据和显示地图,并且该引擎的许多部分被专门编码以满足不同的组织需求。系统采用WEB GIS引擎进行设计。结果:SAMAT系统在全国9个省份不同时期实施。SAMAT仪表板为执行经理提供各种信息。根据人口统计数据,粮食不安全状况可以通过各种图表从城市到村庄的不同层次来确定。可以在地理信息系统地图上确定从城市分布到地方分布的粮食不安全范围。对不同地区进行放大可以帮助确定村庄或城镇内更多的粮食不安全社区,从而使管理人员优先考虑社区或村庄一级的粮食不安全干预措施。可以查看住户特征和问卷调查结果信息。结论:AMAT系统可用于国家、省、市甚至城乡层面的粮食安全管理。我们建议在全面实施减少粮食不安全措施后,定期确定重点,确定省份,并通过基于samat的系统重新评估干预措施的有效性
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引用次数: 1
Prevalence, dimension and location of retromolar canal on cone beam computed tomography: An Analytical cross sectional study 圆锥束计算机断层扫描后磨牙根管的流行、尺寸和位置:一项分析性横断面研究
Pub Date : 2019-09-10 DOI: 10.29252/JORJANIBIOMEDJ.7.3.68
Khalil Sarikhani Khorami, F. Ardakani, Y. Safi, Motahare Baghestani
baghestani.motahare@ yahoo.com Abstract Background and objectives: The retromolar canal is an anatomical variant that needs consideration in local anesthesia and surgical procedures involving the retromolar area. Complications such as local anesthetic insufficiency, a sensory deficit, hemorrhage and traumatic neuroma may arise in the absence of recognition of these variants. The aim of this study is to determine the prevalence and course of retromolar canal in the Iranian population. Methods: This study is a descriptive cross sectional study. The cross sectional sagittal and three dimensional images from volumetric CBCT. data of 270 patients were reconstructed using on demand imaging analysis software. Retromolar canals were classified into two types according to the courses. The width and location (distance from the third molar) of retromolar canals were evaluated. Results were analyzed with SPSS 20 software and were assessed using the t_test and chi_square test. Results: Retromolar canal was observed in 9/25 % of patients. The mean width of the retromolar foramen was 1/43 mm, and the mean distance from anterior border of retromolar foramen to the distal CEJ of the second molar was 13/33 mm. Conclusion: The prevalence of retromolar canals in the Iranian population was lower than that was reported in previous studies. It can be observed in 9/25 % of Iranian patients. Damage to the retromolar canal may be unavoidable during surgical procedures may result in paresthesia, excessive bleeding, postoperative hematoma, or traumatic neuroma. Therefore, the clinician must pay particular attention to the identification of a retromolar canal by preoperative radiographic examination and additional CBCT scanning is recommended.
baghestani。摘要背景和目的:磨牙后根管是一种解剖变异,需要在局部麻醉和涉及磨牙后区域的外科手术中加以考虑。如局部麻醉功能不全、感觉缺陷、出血和创伤性神经瘤等并发症可能在缺乏对这些变异的识别时出现。本研究的目的是确定伊朗人口中后磨牙管的患病率和病程。方法:本研究采用描述性横断面研究。体积CBCT的横切面矢状面和三维图像。应用随需应变影像分析软件对270例患者的数据进行重建。后磨牙根管按径分为两类。评估磨牙后管的宽度和位置(距第三磨牙的距离)。采用SPSS 20软件对结果进行分析,并采用t_test和chi_square检验进行评估。结果:9/ 25%的患者出现后磨牙根管。磨牙后孔平均宽度为1/43 mm,磨牙后孔前缘至第二磨牙远端CEJ的平均距离为13/33 mm。结论:伊朗人群中后磨牙管的患病率低于以往研究报道。9/ 25%的伊朗患者可见此病。在手术过程中,对磨牙后管的损伤是不可避免的,可能导致感觉异常、大出血、术后血肿或创伤性神经瘤。因此,临床医生必须特别注意通过术前x线检查识别后磨牙管,并建议进行额外的CBCT扫描。
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引用次数: 1
Association of Interferon-gamma Gene Polymorphism (+874 A/T) and Oral Lichen planus susceptibility: Systematic Review and Meta-Analysis 干扰素γ基因多态性(+874 A/T)与口腔扁平苔藓易感性的关系:系统评价和荟萃分析
Pub Date : 2019-09-01 DOI: 10.29252/jorjanibiomedj.7.3.45
P. Motahari, F. P. Azar, Parisa Rasouly
paria@motahari.com Abstract Background and objectives: Most studies have identified interferon-gamma (IFN-γ) as a key role in the pathogenesis of oral lichen planus (OLP). Recent studies have also shown a link between IFN-γ (+874 A/T) gene polymorphism and OLP. The purpose of the present meta-analysis is to investigate the relationship between IFN-γ (+874 A/T) gene polymorphism and susceptibility to OLP. Methods: A systematic search of resources to investigate the association between IFN-γ and OLP from Google scholar, PubMed, Embase, Cochrane, Scopus, Proquest, Ovid and Web of science (from 2000 to April 2019) completed. Two individuals independently assessed the quality of the articles. Endnote X5 resource management software was used to organize, study titles and abstracts as well as identify duplicates. A random effect model was also used to perform the meta-analysis. Results: Four IFN-γ (+874 A/T) polymorphism studies with 297 patients in the case group and 621 healthy controls in the 4 different countries were included. After metaanalysis, a significant association was found between IFN-γ polymorphism (+874 A/T) and OLP. (T vs A: odds ratio (OR) = 1.62; 95% CI = 1.28-2.04; TT vs AA: OR = 2.67; 95% CI = 1.64.45; AT vs AA: OR = 1.56; 95% CI = 1.64.45; TT vs AT + AA: OR = 1.73; 95% CI = 1.13-2.64; AT + TT vs AA: OR = 1.75; 95% CI = 1.28-2.43) Conclusion: Based on this meta-analysis, there was a positive relationship between IFNγ (+874 A/T) gene polymorphism and the risk of OLP. The findings showed that increasing TT genotypes significantly increased susceptibility to OLP in comparison with other genotypes.
paria@motahari.com摘要背景和目的:大多数研究已经确定干扰素-γ (IFN-γ)在口腔扁平苔藓(OLP)的发病机制中起关键作用。最近的研究也表明IFN-γ (+874 a /T)基因多态性与OLP之间存在联系。本荟萃分析的目的是探讨IFN-γ (+874 A/T)基因多态性与OLP易感性之间的关系。方法:系统检索谷歌scholar、PubMed、Embase、Cochrane、Scopus、Proquest、Ovid和Web of science(2000 - 2019年4月)的资源,调查IFN-γ与OLP之间的关系。两个人独立评估了文章的质量。使用Endnote X5资源管理软件组织、研究标题和摘要,并识别重复。采用随机效应模型进行meta分析。结果:4项IFN-γ (+874 A/T)多态性研究纳入病例组297例患者和来自4个不同国家的621例健康对照。经过荟萃分析,发现IFN-γ多态性(+874 a /T)与OLP之间存在显著关联。(T vs A:优势比(OR) = 1.62;95% ci = 1.28-2.04;TT vs AA: OR = 2.67;95% ci = 1.64.45;AT vs AA: OR = 1.56;95% ci = 1.64.45;TT vs AT + AA: OR = 1.73;95% ci = 1.13-2.64;AT + TT vs AA: OR = 1.75;结论:基于meta分析,IFNγ (+874 a /T)基因多态性与OLP发病风险呈正相关。结果表明,与其他基因型相比,TT基因型的增加显著增加了对OLP的易感性。
{"title":"Association of Interferon-gamma Gene Polymorphism (+874 A/T) and Oral Lichen planus susceptibility: Systematic Review and Meta-Analysis","authors":"P. Motahari, F. P. Azar, Parisa Rasouly","doi":"10.29252/jorjanibiomedj.7.3.45","DOIUrl":"https://doi.org/10.29252/jorjanibiomedj.7.3.45","url":null,"abstract":"paria@motahari.com Abstract Background and objectives: Most studies have identified interferon-gamma (IFN-γ) as a key role in the pathogenesis of oral lichen planus (OLP). Recent studies have also shown a link between IFN-γ (+874 A/T) gene polymorphism and OLP. The purpose of the present meta-analysis is to investigate the relationship between IFN-γ (+874 A/T) gene polymorphism and susceptibility to OLP. Methods: A systematic search of resources to investigate the association between IFN-γ and OLP from Google scholar, PubMed, Embase, Cochrane, Scopus, Proquest, Ovid and Web of science (from 2000 to April 2019) completed. Two individuals independently assessed the quality of the articles. Endnote X5 resource management software was used to organize, study titles and abstracts as well as identify duplicates. A random effect model was also used to perform the meta-analysis. Results: Four IFN-γ (+874 A/T) polymorphism studies with 297 patients in the case group and 621 healthy controls in the 4 different countries were included. After metaanalysis, a significant association was found between IFN-γ polymorphism (+874 A/T) and OLP. (T vs A: odds ratio (OR) = 1.62; 95% CI = 1.28-2.04; TT vs AA: OR = 2.67; 95% CI = 1.64.45; AT vs AA: OR = 1.56; 95% CI = 1.64.45; TT vs AT + AA: OR = 1.73; 95% CI = 1.13-2.64; AT + TT vs AA: OR = 1.75; 95% CI = 1.28-2.43) Conclusion: Based on this meta-analysis, there was a positive relationship between IFNγ (+874 A/T) gene polymorphism and the risk of OLP. The findings showed that increasing TT genotypes significantly increased susceptibility to OLP in comparison with other genotypes.","PeriodicalId":14723,"journal":{"name":"Jorjani Biomedicine Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76590021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Increased Expression of miR-202-3p in Patients with Relapsing-Remitting Multiple Sclerosis miR-202-3p在复发缓解型多发性硬化症患者中的表达升高
Pub Date : 2018-12-01 DOI: 10.29252/jorjanibiomedj.6.4.8
Majid Amini Khorasgani, Parisa Mohammady Nejad, Mohammad Mehdi Moghani Bashi
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引用次数: 4
Analysis of Current and Desirable Status of Iran's Basic Health Insurance 伊朗基本医疗保险现状与理想状况分析
Pub Date : 2018-12-01 DOI: 10.29252/JORJANIBIOMEDJ.6.4.53
Roohollah Gholikhani, F. Azar, M. Kabir, M. M. Tadayon
1. Department of public law, Faculty of law (campus), Tehran University, Tehran, Iran 2. Department of Health Services, School of Public Health, Iran University of Medical Science, Tehran, Iran 3. Department of Family and Community Medicine, School of Medicine Golestan University of Medical Sciences, Gorgan, Iran. 4. National Center for Health insurance Research. (NCHIR). Iran. Health Insurance Organization (IHIO)
1. 德黑兰大学法学院(校区)公法系,伊朗德黑兰2 .伊朗医科大学公共卫生学院卫生服务系,伊朗德黑兰3 .伊朗戈勒斯坦医科大学医学院家庭与社区医学系,戈勒斯坦;国家健康保险研究中心。(NCHIR)。伊朗。健康保险组织(IHIO)
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引用次数: 0
Anti -Bacterial Activity of Punica granatum Flower Extract against Several Gram-Negative and Positive Bacteria 石榴花提取物对几种革兰氏阴性菌和阳性菌的抑菌活性
Pub Date : 2018-12-01 DOI: 10.29252/JORJANIBIOMEDJ.6.4.1
Ali Ahmadi, N. Soleimani, parham abedini
Antibiotic resistance is considered as one of the world's most pressing public health problems. Almost every type of bacteria has become stronger and less responsive to antibiotic treatment (1, 2). Thesis antibioticresistant bacteria can quickly spread to family members, schoolmates, and co-workers thus threatening the community with a new strain of infectious disease that is more difficult to cure and more expensive to treat. For this reason, antibiotic resistance is among the top concerns of the Center for Disease Control Article Type: Original Article
抗生素耐药性被认为是世界上最紧迫的公共卫生问题之一。几乎所有类型的细菌都变得更强,对抗生素治疗的反应更弱(1,2)。抗生素耐药细菌可以迅速传播给家庭成员、同学和同事,从而威胁到社区的一种新的传染病,这种传染病更难治愈,治疗费用也更高。由于这个原因,抗生素耐药性是疾病控制中心最关注的问题之一
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引用次数: 0
Evaluation of the antimicrobial effects of Glycyrrhiza glabra l. on some gram positive and gram negative pathogenic bacteria in laboratory conditions 甘草对革兰氏阳性和革兰氏阴性致病菌的实验室抑菌效果评价
Pub Date : 2018-12-01 DOI: 10.29252/JORJANIBIOMEDJ.6.4.78
Abolfazl Jafari-Sales, P. Bolouri
Medicinal herbs have always been closely related to humans and plants throughout the development of all civilizations. Although most plant species are known to date, there is still a long way to discover new and valuable herbal resources (1, 2). In this way, plants can be considered as a useful source of chemicals, only a part of which has been identified. These potentially useful chemicals can be used not only as a medicine but as an unrivaled model as the starting point for making pharmaceutical analogues, as well as Article Type: Original Article
在人类文明的发展过程中,草药一直与人类和植物密切相关。虽然大多数植物物种是已知的,但仍有很长的路要走,以发现新的和有价值的草药资源(1,2)。在这种情况下,植物可以被认为是一个有用的来源的化学物质,其中只有一部分已被确定。这些潜在有用的化学物质不仅可以用作药物,而且可以作为制造药物类似物的起点的无与伦比的模型,以及文章类型:原创文章
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引用次数: 13
Increased Expression of Bax and Bcl2 Apoptosis Biomarkers in the Heart of Old Female Rats After Interval Training and Curcumin Consumption 间隔训练和姜黄素摄入后老年雌性大鼠心脏中Bax和Bcl2凋亡生物标志物的表达增加
Pub Date : 2018-12-01 DOI: 10.29252/JORJANIBIOMEDJ.6.4.40
Bahareh Yazdanparast Chaharmahali, M. Azarbayjani, M. Peeri, Parvin Farzanegi Arkhazloo
Elderly is described as a decrease in general physiological function (1). Gradual changes in the functions of a living creature ultimately lead to his death. Elderly is characterized by a decrease in cardiac function, including impulse volume, cardiac outflow, blood flow, oxygen uptake, and increased readiness for inflammation, oxidative stress, and diseases. With no heart functioning, inflammatory cytokines increase, and increased oxidative Article Type: Original Article
衰老被描述为一般生理功能的下降(1)。生物功能的逐渐变化最终导致其死亡。老年人的特点是心功能下降,包括冲量、心流出量、血流量、摄氧量,以及对炎症、氧化应激和疾病的抵抗力增加。没有心脏功能,炎症细胞因子增加,氧化增加
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引用次数: 4
期刊
Jorjani Biomedicine Journal
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