Pub Date : 2026-01-14DOI: 10.1001/jamadermatol.2025.5481
Ryan A Gall, Carly A Wooten, Willis H Lyford
{"title":"Effects of Photographic Image Processing in Dermatology.","authors":"Ryan A Gall, Carly A Wooten, Willis H Lyford","doi":"10.1001/jamadermatol.2025.5481","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.5481","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.1001/jamadermatol.2025.4892
Peyton V Warp, Karishma R Desai, Alvaro J Alencar, Jonathan J Cohen, Andrea D Maderal
{"title":"Zanubrutinib for Immunoglobulin A Vasculitis With Monoclonal Gammopathy.","authors":"Peyton V Warp, Karishma R Desai, Alvaro J Alencar, Jonathan J Cohen, Andrea D Maderal","doi":"10.1001/jamadermatol.2025.4892","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.4892","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.1001/jamadermatol.2025.5205
Christopher Willy Schwarz, Nikolai Loft, Lars Erik Bryld, Christoffer Valdemar Nissen, Kawa Khaled Ajgeiy, Trine Bertelsen, Kasper Fjellhaugen Hjuler, Tomas Norman Dam, Lars Iversen, Mads Kirchheiner Rasmussen, Lone Skov
<p><strong>Importance: </strong>Drug survival is an important measure to help guide treatment selection. However, clinical evidence for newer biologics, including bimekizumab, is limited.</p><p><strong>Objective: </strong>To determine the drug survival of biologics used for treating psoriasis in a routine clinical practice setting.</p><p><strong>Design, setting, and participants: </strong>This cohort study was based on data from the DERMBIO registry, which includes all patients treated with biologics for psoriasis in Denmark. All adult patients enrolled in DERMBIO from its inception in May 2007 until June 2025 were assessed for eligibility. Data were extracted in June 2025 and analyzed separately among those without previous biologic exposure (bionaive patients) and those with previous biologic exposure (bioexperienced patients).</p><p><strong>Exposures: </strong>Adalimumab, secukinumab, and ustekinumab among bionaive patients and adalimumab, bimekizumab, brodalumab, guselkumab, ixekizumab, risankizumab, secukinumab, and ustekinumab among bioexperienced patients.</p><p><strong>Main outcomes and measures: </strong>The main outcome was standardized absolute risks of treatment discontinuation at 1, 2, and 5 years. Kaplan-Meier estimator was used to determine crude drug survival estimates and the Aalen-Johansen estimator was used to determine crude cause-specific absolute risks.</p><p><strong>Results: </strong>The study included 4438 unique patients with psoriasis (2717 [61.2%] male; mean [SD] age, 45.0 [14.6] years at the time of their first treatment included in the study), 1039 (23.4%) of whom had comorbid psoriatic arthritis. A total of 3790 treatment series from bionaive patients were analyzed: 2646 were with adalimumab, 377 with secukinumab, and 767 with ustekinumab. The 5-year standardized risk of discontinuing ustekinumab was 0.37 (95% CI, 0.33-0.41), which was significantly lower than the standardized risks for adalimumab (0.51; 95% CI, 0.49-0.54) and secukinumab (0.54; 95% CI, 0.48-0.60). A total of 3403 treatment series from bioexperienced patients were analyzed: 790 were with adalimumab, 376 with bimekizumab, 192 with brodalumab, 218 with guselkumab, 556 with ixekizumab, 78 with risankizumab, 466 with secukinumab, and 727 with ustekinumab. The 2-year standardized absolute risk of discontinuing ustekinumab was 0.39 (95% CI, 0.36-0.43). Only bimekizumab (0.27; 95% CI, 0.20-0.34), guselkumab (0.29; 95% CI, 0.22-0.36), and risankizumab (0.25; 95% CI, 0.15-0.36) were associated with a significantly lower standardized absolute risk of discontinuation compared with ustekinumab.</p><p><strong>Conclusions and relevance: </strong>In this cohort study in Denmark, among bionaive patients with psoriasis, ustekinumab had superior drug survival compared with adalimumab and secukinumab, and among bioexperienced patients with psoriasis, bimekizumab, guselkumab, and risankizumab had superior drug survival. These results offer insight into the performance o
{"title":"Drug Survival of Biologics in Bionaive and Bioexperienced Patients With Psoriasis.","authors":"Christopher Willy Schwarz, Nikolai Loft, Lars Erik Bryld, Christoffer Valdemar Nissen, Kawa Khaled Ajgeiy, Trine Bertelsen, Kasper Fjellhaugen Hjuler, Tomas Norman Dam, Lars Iversen, Mads Kirchheiner Rasmussen, Lone Skov","doi":"10.1001/jamadermatol.2025.5205","DOIUrl":"10.1001/jamadermatol.2025.5205","url":null,"abstract":"<p><strong>Importance: </strong>Drug survival is an important measure to help guide treatment selection. However, clinical evidence for newer biologics, including bimekizumab, is limited.</p><p><strong>Objective: </strong>To determine the drug survival of biologics used for treating psoriasis in a routine clinical practice setting.</p><p><strong>Design, setting, and participants: </strong>This cohort study was based on data from the DERMBIO registry, which includes all patients treated with biologics for psoriasis in Denmark. All adult patients enrolled in DERMBIO from its inception in May 2007 until June 2025 were assessed for eligibility. Data were extracted in June 2025 and analyzed separately among those without previous biologic exposure (bionaive patients) and those with previous biologic exposure (bioexperienced patients).</p><p><strong>Exposures: </strong>Adalimumab, secukinumab, and ustekinumab among bionaive patients and adalimumab, bimekizumab, brodalumab, guselkumab, ixekizumab, risankizumab, secukinumab, and ustekinumab among bioexperienced patients.</p><p><strong>Main outcomes and measures: </strong>The main outcome was standardized absolute risks of treatment discontinuation at 1, 2, and 5 years. Kaplan-Meier estimator was used to determine crude drug survival estimates and the Aalen-Johansen estimator was used to determine crude cause-specific absolute risks.</p><p><strong>Results: </strong>The study included 4438 unique patients with psoriasis (2717 [61.2%] male; mean [SD] age, 45.0 [14.6] years at the time of their first treatment included in the study), 1039 (23.4%) of whom had comorbid psoriatic arthritis. A total of 3790 treatment series from bionaive patients were analyzed: 2646 were with adalimumab, 377 with secukinumab, and 767 with ustekinumab. The 5-year standardized risk of discontinuing ustekinumab was 0.37 (95% CI, 0.33-0.41), which was significantly lower than the standardized risks for adalimumab (0.51; 95% CI, 0.49-0.54) and secukinumab (0.54; 95% CI, 0.48-0.60). A total of 3403 treatment series from bioexperienced patients were analyzed: 790 were with adalimumab, 376 with bimekizumab, 192 with brodalumab, 218 with guselkumab, 556 with ixekizumab, 78 with risankizumab, 466 with secukinumab, and 727 with ustekinumab. The 2-year standardized absolute risk of discontinuing ustekinumab was 0.39 (95% CI, 0.36-0.43). Only bimekizumab (0.27; 95% CI, 0.20-0.34), guselkumab (0.29; 95% CI, 0.22-0.36), and risankizumab (0.25; 95% CI, 0.15-0.36) were associated with a significantly lower standardized absolute risk of discontinuation compared with ustekinumab.</p><p><strong>Conclusions and relevance: </strong>In this cohort study in Denmark, among bionaive patients with psoriasis, ustekinumab had superior drug survival compared with adalimumab and secukinumab, and among bioexperienced patients with psoriasis, bimekizumab, guselkumab, and risankizumab had superior drug survival. These results offer insight into the performance o","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12780981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.1001/jamadermatol.2025.5268
Debby Cheng, Nora Bensellam, Katherine Sanchez, Aurore D Zhang, Ursula Biba, Sherry Ershadi, Samantha Gregoire, Nikki Zangenah, Lorena A Acevedo-Fontanez, Anne Fladger, Nicholas Theodosakis, Arash Mostaghimi, John S Barbieri
<p><strong>Importance: </strong>Accurate classification of dermatologic conditions using International Classification of Diseases (ICD) codes is essential for research that uses large administrative datasets. Misclassification can be associated with biased epidemiologic estimates and misleading conclusions in population-based studies.</p><p><strong>Objective: </strong>To systematically identify and evaluate validated classification approaches for dermatologic conditions using ICD codes in US-based administrative, claims, or electronic health record data.</p><p><strong>Evidence review: </strong>A systematic review was conducted that was registered with PROSPERO (CRD420250654233) and reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive search of Ovid MEDLINE, Embase, Web of Science, and CINAHL was conducted for studies published from January 1, 2000, to October 21, 2025. The data were analyzed in October 2025. Eligible studies evaluated International Classification of Diseases, Ninth Revision (ICD-9) or International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) codes used to identify dermatologic conditions in US-based datasets and reported at least 1 classification metric (eg, positive predictive value). To minimize selection and extraction bias, all screening and data extraction were performed independently by 2 reviewers, with discrepancies resolved by consensus.</p><p><strong>Findings: </strong>A total of 59 studies met inclusion criteria. Most reported positive predictive value, with few reporting sensitivity or specificity. Classification accuracy varied widely by condition and coding strategy. Studies included inflammatory and autoimmune conditions (eg, acne vulgaris, perioral dermatitis, psoriasis, palmoplantar pustulosis, hidradenitis suppurativa, atopic dermatitis, prurigo nodularis, dermatomyositis, cutaneous lupus erythematosus, pyoderma gangrenosum, cutaneous sarcoidosis, pemphigus, pemphigoid, granuloma annulare, alopecia areata, and vitiligo), actinic keratosis and skin cancer, pigmentary and hair disorders (eg, androgenic alopecia, cicatricial alopecia, lichen planopilaris, and melasma), drug reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis), and infections (eg, herpes zoster, herpes simplex virus, and cellulitis or abscess). Classification algorithms that incorporated 2 or more codes, dermatologist attribution, or treatment/procedural data often achieved the highest accuracy. Conditions lacking validated algorithms included seborrheic dermatitis, rosacea, fungal infections, and specific alopecia subtypes.</p><p><strong>Conclusions and relevance: </strong>This systematic review provides a summary of the most accurate classification approaches to identify various dermatologic conditions in large administrative datasets. These results may inform study designs when using these datasets. In addition, some com
重要性：使用国际疾病分类（ICD）代码对皮肤病进行准确分类对于使用大型管理数据集的研究至关重要。在基于人群的研究中，错误分类可能与有偏见的流行病学估计和误导性结论有关。目的：系统地识别和评估在美国行政、索赔或电子健康记录数据中使用ICD代码的皮肤疾病的有效分类方法。证据回顾：系统回顾已在PROSPERO注册（CRD420250654233），并根据系统回顾和荟萃分析指南的首选报告项目进行报告。对2000年1月1日至2025年10月21日期间发表的研究进行了Ovid MEDLINE、Embase、Web of Science和CINAHL的综合检索。这些数据是在2025年10月进行分析的。符合条件的研究评估了用于识别美国数据集中皮肤病的国际疾病分类第九版（ICD-9）或国际疾病和相关健康问题统计分类第十版（ICD-10）代码，并报告了至少1个分类指标（例如，阳性预测值）。为了尽量减少选择和提取的偏倚，所有筛选和数据提取均由2位审稿人独立完成，差异通过共识解决。结果：共有59项研究符合纳入标准。大多数报告阳性预测值，很少报告敏感性或特异性。分类精度因条件和编码策略的不同而有很大差异。研究包括炎症和自身免疫性疾病（如：寻常痤疮、口周皮炎、银屑病、掌跖脓肿、化脓性汗腺炎、特应性皮炎、结节性痒疹、皮肌炎、皮肤红斑狼疮、坏疽性脓皮病、皮肤结节病、天疱疮、类天疱疮、环状肉芽肿、斑秃和白癜风）、光化性角化病和皮肤癌、色素和头发疾病(如：雄激素性脱发、瘢痕性脱发、扁平苔藓、和黄褐斑)、药物反应（如史蒂文斯-约翰逊综合征、中毒性表皮坏死松解）和感染（如带状疱疹、单纯疱疹病毒、蜂窝织炎或脓肿）。包含2个或更多代码、皮肤科医生归因或治疗/程序数据的分类算法通常达到最高的准确性。缺乏有效算法的条件包括脂溢性皮炎、酒渣鼻、真菌感染和特定的脱发亚型。结论和相关性：本系统综述总结了在大型管理数据集中识别各种皮肤病的最准确分类方法。当使用这些数据集时，这些结果可以为研究设计提供信息。此外，一些常见情况缺乏经过验证的分类方法，这突出了未来研究的重要领域。随着行政和电子健康记录数据越来越多地支持皮肤病学研究，使用严格验证的算法对于产生可信的发现至关重要。
{"title":"Validation of International Classification of Diseases Codes for Dermatologic Conditions: A Systematic Review.","authors":"Debby Cheng, Nora Bensellam, Katherine Sanchez, Aurore D Zhang, Ursula Biba, Sherry Ershadi, Samantha Gregoire, Nikki Zangenah, Lorena A Acevedo-Fontanez, Anne Fladger, Nicholas Theodosakis, Arash Mostaghimi, John S Barbieri","doi":"10.1001/jamadermatol.2025.5268","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.5268","url":null,"abstract":"<p><strong>Importance: </strong>Accurate classification of dermatologic conditions using International Classification of Diseases (ICD) codes is essential for research that uses large administrative datasets. Misclassification can be associated with biased epidemiologic estimates and misleading conclusions in population-based studies.</p><p><strong>Objective: </strong>To systematically identify and evaluate validated classification approaches for dermatologic conditions using ICD codes in US-based administrative, claims, or electronic health record data.</p><p><strong>Evidence review: </strong>A systematic review was conducted that was registered with PROSPERO (CRD420250654233) and reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive search of Ovid MEDLINE, Embase, Web of Science, and CINAHL was conducted for studies published from January 1, 2000, to October 21, 2025. The data were analyzed in October 2025. Eligible studies evaluated International Classification of Diseases, Ninth Revision (ICD-9) or International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) codes used to identify dermatologic conditions in US-based datasets and reported at least 1 classification metric (eg, positive predictive value). To minimize selection and extraction bias, all screening and data extraction were performed independently by 2 reviewers, with discrepancies resolved by consensus.</p><p><strong>Findings: </strong>A total of 59 studies met inclusion criteria. Most reported positive predictive value, with few reporting sensitivity or specificity. Classification accuracy varied widely by condition and coding strategy. Studies included inflammatory and autoimmune conditions (eg, acne vulgaris, perioral dermatitis, psoriasis, palmoplantar pustulosis, hidradenitis suppurativa, atopic dermatitis, prurigo nodularis, dermatomyositis, cutaneous lupus erythematosus, pyoderma gangrenosum, cutaneous sarcoidosis, pemphigus, pemphigoid, granuloma annulare, alopecia areata, and vitiligo), actinic keratosis and skin cancer, pigmentary and hair disorders (eg, androgenic alopecia, cicatricial alopecia, lichen planopilaris, and melasma), drug reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis), and infections (eg, herpes zoster, herpes simplex virus, and cellulitis or abscess). Classification algorithms that incorporated 2 or more codes, dermatologist attribution, or treatment/procedural data often achieved the highest accuracy. Conditions lacking validated algorithms included seborrheic dermatitis, rosacea, fungal infections, and specific alopecia subtypes.</p><p><strong>Conclusions and relevance: </strong>This systematic review provides a summary of the most accurate classification approaches to identify various dermatologic conditions in large administrative datasets. These results may inform study designs when using these datasets. In addition, some com","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.1001/jamadermatol.2025.4097
Daniel R Mazori, Ruth Ann Vleugels, Alisa N Femia
{"title":"Eosinophilic Fasciitis.","authors":"Daniel R Mazori, Ruth Ann Vleugels, Alisa N Femia","doi":"10.1001/jamadermatol.2025.4097","DOIUrl":"https://doi.org/10.1001/jamadermatol.2025.4097","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1001/jamadermatol.2025.4427
Raphaël Ouakrat, Laetitia Penso, Denis Jullien, Harry Sokol, Emilie Sbidian
Importance: The long-term effectiveness of biologic therapies in psoriasis may decline over time. Gut microbiota alterations induced by antibiotics have been proposed as a potential mechanism impairing biologic persistence.
Objective: To evaluate the association between antibiotic exposure and the persistence of biologic therapies in patients with psoriasis.
Design, setting, and participants: This retrospective cohort study used data from the French National Health Insurance database between June 2011 and December 2022. Adults initiating a biologic therapy for psoriasis were included, excluding those with preexisting inflammatory bowel disease at baseline. Data were analyzed from January to September 2024.
Exposures: At baseline, antibiotics exposure was classified as none, 1, or 2 or more dispensations in the 6 months preceding the index date. During follow-up, time-dependent antibiotics exposure was defined as none, 1, or 2 or more antibiotics dispensations in the 6 months prior to each time of follow-up.
Main outcomes and measures: The primary outcome was discontinuation or switch of the initial biologic therapy. Exposure to antibiotics was assessed within 6 months prior to biologic initiation and during follow-up. A weighted Cox marginal structural model was used to estimate adjusted hazard ratios.
Results: Of 36 129 included patients, 11 228 (42.0%) were female, 20 192 (55.9%) were male, and the mean (SD) age was 48.4 (15.1) years. A total of 9366 (25.9%) were exposed to antibiotics at baseline and 21 900 (60.6%) during follow-up. The most commonly prescribed antibiotic classes were β-lactams, macrolides, and fluoroquinolones. Antibiotic exposure was associated with a higher risk of biologic discontinuation (weighted hazard ratio, 1.12; 95% CI, 1.08-1.16), with a stronger effect observed for multiple dispensations (weighted hazard ratio, 1.29; 95% CI, 1.24-1.35), suggesting a dose-response relationship.
Conclusions and relevance: In this cohort study, antibiotic exposure was significantly associated with an increased risk of discontinuation of biologic therapies in psoriasis. These findings support the hypothesis that antibiotics, potentially through gut dysbiosis, may reduce biologic persistence. However, unmeasured confounders limit causal interpretation. Further studies are necessary to validate these findings.
{"title":"Antibiotic Use and the Persistence of Biologic Therapies in Patients With Psoriasis.","authors":"Raphaël Ouakrat, Laetitia Penso, Denis Jullien, Harry Sokol, Emilie Sbidian","doi":"10.1001/jamadermatol.2025.4427","DOIUrl":"10.1001/jamadermatol.2025.4427","url":null,"abstract":"<p><strong>Importance: </strong>The long-term effectiveness of biologic therapies in psoriasis may decline over time. Gut microbiota alterations induced by antibiotics have been proposed as a potential mechanism impairing biologic persistence.</p><p><strong>Objective: </strong>To evaluate the association between antibiotic exposure and the persistence of biologic therapies in patients with psoriasis.</p><p><strong>Design, setting, and participants: </strong>This retrospective cohort study used data from the French National Health Insurance database between June 2011 and December 2022. Adults initiating a biologic therapy for psoriasis were included, excluding those with preexisting inflammatory bowel disease at baseline. Data were analyzed from January to September 2024.</p><p><strong>Exposures: </strong>At baseline, antibiotics exposure was classified as none, 1, or 2 or more dispensations in the 6 months preceding the index date. During follow-up, time-dependent antibiotics exposure was defined as none, 1, or 2 or more antibiotics dispensations in the 6 months prior to each time of follow-up.</p><p><strong>Main outcomes and measures: </strong>The primary outcome was discontinuation or switch of the initial biologic therapy. Exposure to antibiotics was assessed within 6 months prior to biologic initiation and during follow-up. A weighted Cox marginal structural model was used to estimate adjusted hazard ratios.</p><p><strong>Results: </strong>Of 36 129 included patients, 11 228 (42.0%) were female, 20 192 (55.9%) were male, and the mean (SD) age was 48.4 (15.1) years. A total of 9366 (25.9%) were exposed to antibiotics at baseline and 21 900 (60.6%) during follow-up. The most commonly prescribed antibiotic classes were β-lactams, macrolides, and fluoroquinolones. Antibiotic exposure was associated with a higher risk of biologic discontinuation (weighted hazard ratio, 1.12; 95% CI, 1.08-1.16), with a stronger effect observed for multiple dispensations (weighted hazard ratio, 1.29; 95% CI, 1.24-1.35), suggesting a dose-response relationship.</p><p><strong>Conclusions and relevance: </strong>In this cohort study, antibiotic exposure was significantly associated with an increased risk of discontinuation of biologic therapies in psoriasis. These findings support the hypothesis that antibiotics, potentially through gut dysbiosis, may reduce biologic persistence. However, unmeasured confounders limit causal interpretation. Further studies are necessary to validate these findings.</p>","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":"55-59"},"PeriodicalIF":11.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12613086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145494359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1001/jamadermatol.2025.4879
Andrea D Maderal
{"title":"Use of Botulinum Toxin for Advanced Tissue Ischemia.","authors":"Andrea D Maderal","doi":"10.1001/jamadermatol.2025.4879","DOIUrl":"10.1001/jamadermatol.2025.4879","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":"54"},"PeriodicalIF":11.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145714289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1001/jamadermatol.2025.3986
Rachel Zhang, Joy Wan
Clinical question: Which topical anti-inflammatory treatments are most effective and safe for managing atopic dermatitis?
Bottom line: In a network meta-analyses, very potent/potent topical corticosteroids; tacrolimus, 0.1%; and topical Janus kinase inhibitors were among the most effective treatments for short-term control of atopic dermatitis symptoms, while phosphodiesterase-4 inhibitors were among the least effective. Topical calcineurin inhibitors and crisaborole were associated with application-site irritation, and short-term topical steroid use was not associated with skin thinning. However, these findings were of low to moderate certainty, and longer-term data remain limited for many agents.
{"title":"Topical Anti-Inflammatory Treatments for Atopic Dermatitis.","authors":"Rachel Zhang, Joy Wan","doi":"10.1001/jamadermatol.2025.3986","DOIUrl":"10.1001/jamadermatol.2025.3986","url":null,"abstract":"<p><strong>Clinical question: </strong>Which topical anti-inflammatory treatments are most effective and safe for managing atopic dermatitis?</p><p><strong>Bottom line: </strong>In a network meta-analyses, very potent/potent topical corticosteroids; tacrolimus, 0.1%; and topical Janus kinase inhibitors were among the most effective treatments for short-term control of atopic dermatitis symptoms, while phosphodiesterase-4 inhibitors were among the least effective. Topical calcineurin inhibitors and crisaborole were associated with application-site irritation, and short-term topical steroid use was not associated with skin thinning. However, these findings were of low to moderate certainty, and longer-term data remain limited for many agents.</p>","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":" ","pages":"80-82"},"PeriodicalIF":11.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145389763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：