首页 > 最新文献

JAMA dermatology最新文献

英文 中文
Peristomal Erosion in a Man With Crohn Disease. 一名克罗恩病患者的肛门周围糜烂。
IF 11.5 1区 医学 Q1 DERMATOLOGY Pub Date : 2024-10-09 DOI: 10.1001/jamadermatol.2024.2770
Valentina Caputo, Paolo Romanelli, Franco Rongioletti
{"title":"Peristomal Erosion in a Man With Crohn Disease.","authors":"Valentina Caputo, Paolo Romanelli, Franco Rongioletti","doi":"10.1001/jamadermatol.2024.2770","DOIUrl":"https://doi.org/10.1001/jamadermatol.2024.2770","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":null,"pages":null},"PeriodicalIF":11.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Errors in Figures 1 and 3. 图 1 和图 3 中的误差。
IF 11.5 1区 医学 Q1 DERMATOLOGY Pub Date : 2024-10-09 DOI: 10.1001/jamadermatol.2024.4370
{"title":"Errors in Figures 1 and 3.","authors":"","doi":"10.1001/jamadermatol.2024.4370","DOIUrl":"10.1001/jamadermatol.2024.4370","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":null,"pages":null},"PeriodicalIF":11.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11465116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tralokinumab and Acitretin for the Treatment of Lamellar Ichthyosis. 特罗凯单抗和阿曲汀治疗片状鱼鳞病。
IF 11.5 1区 医学 Q1 DERMATOLOGY Pub Date : 2024-10-09 DOI: 10.1001/jamadermatol.2024.3443
Axel De Greef, Marie Baeck
{"title":"Tralokinumab and Acitretin for the Treatment of Lamellar Ichthyosis.","authors":"Axel De Greef, Marie Baeck","doi":"10.1001/jamadermatol.2024.3443","DOIUrl":"https://doi.org/10.1001/jamadermatol.2024.3443","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":null,"pages":null},"PeriodicalIF":11.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Susceptibility to Hidradenitis Suppurativa and Predisposition to Cardiometabolic Disease. 化脓性扁桃体炎的遗传易感性与心脏代谢疾病的易感性
IF 11.5 1区 医学 Q1 DERMATOLOGY Pub Date : 2024-10-09 DOI: 10.1001/jamadermatol.2024.3779
Valdemar Wendelboe Nielsen, Oliver Bundgaard Vad, Nikolaj Holgersen, Christian Paludan-Müller, Laia Meseguer Monfort, Astrid Filt Beyer, Gregor Borut Ernst Jemec, Rune Kjærsgaard Andersen, Alexander Egeberg, Jacob P Thyssen, Jesper Hastrup Svendsen, Nana Aviaaja Lippert Rosenø, Peter Riis Hansen, Simon Francis Thomsen, Morten Salling Olesen

Importance: Hidradenitis suppurativa (HS) is associated with an increased prevalence of cardiovascular diseases compared with the general population. Any association between polygenic risk for HS, risk of incident cardiometabolic outcomes, and the plasma proteome is unclear.

Objective: To investigate the genetic correlation between HS and cardiometabolic disease.

Design, setting, and participants: This cohort study used a polygenic risk score (PRS) for HS to examine the risks of coronary artery disease (CAD) and diabetes and identify changes in the plasma proteome in individuals of European ancestry from the UK Biobank. Participants were enrolled from January 1, 2006, to December 31, 2010. End of follow-up was January 1, 2023. Correlations were assessed between HS susceptibility and cardiometabolic traits using linkage disequilibrium score regression. Odds ratios were assessed in logistic regressions. The risk of incident CAD and diabetes was estimated in cause-specific survival models designed as time-to-event analyses.

Exposure: The PRS for HS.

Main outcomes and measures: Main outcomes were CAD and diabetes diagnosis measured by logistic regressions and incident disease measured by Cox proportional hazards regression models adjusted for sex, age, body mass index, and smoking status.

Results: The study included 391 481 individuals (median [IQR] age, 58 [51-64] years; 209 235 [53%] female). Genetic variants for HS correlated significantly with variants associated with CAD, diabetes, and plasma levels of high-density lipoprotein cholesterol, triglycerides, and C-reactive protein. Compared with the low-risk group, a high PRS for HS (≥75th percentile) conferred odds ratios of 1.09 (95% CI, 1.06-1.12; P < .001) for CAD and 1.13 (95% CI, 1.10-1.17; P < .001) for diabetes. Estimates remained consistent when examining only incident CAD and diabetes. The PRS for HS was significantly associated with altered expression of 58 plasma proteins. Integrating this proteomic profile and the PRS for HS in a machine learning model improved prediction of CAD and diabetes compared with a reference model based on sex, age, and body mass index.

Conclusions and relevance: These findings suggest that a high genetic risk of HS is associated with increased risk of subsequent CAD and diabetes and altered composition of the plasma proteome. Additional investigation into the identified proteins and their potential roles as drug targets is warranted.

重要性:与普通人群相比,化脓性扁桃体炎(HS)与心血管疾病发病率增加有关。HS的多基因风险、心血管代谢疾病的发病风险与血浆蛋白质组之间的关系尚不清楚:研究 HS 与心血管代谢疾病之间的遗传相关性:这项队列研究使用 HS 的多基因风险评分 (PRS) 来检测冠状动脉疾病 (CAD) 和糖尿病的风险,并确定英国生物库中欧洲血统个体血浆蛋白质组的变化。参与者的注册时间为 2006 年 1 月 1 日至 2010 年 12 月 31 日。随访结束日期为 2023 年 1 月 1 日。采用连锁不平衡得分回归法评估了HS易感性与心脏代谢特征之间的相关性。在逻辑回归中评估了比值比。在特定病因生存模型中估算发生 CAD 和糖尿病的风险,该模型设计为时间到事件分析:主要结果是通过逻辑回归测量的 CAD 和糖尿病诊断,以及根据性别、年龄、体重指数和吸烟状况调整的 Cox 比例危险回归模型测量的突发疾病:研究共纳入 391 481 人(中位数[IQR]年龄 58 [51-64] 岁;女性 209 235 [53%])。HS的基因变异与CAD、糖尿病以及血浆中高密度脂蛋白胆固醇、甘油三酯和C反应蛋白水平的相关变异有显著相关性。与低风险组相比,HS 的高 PRS(≥75 百分位数)带来的几率比为 1.09(95% CI,1.06-1.12;P 结论及相关性:这些研究结果表明,HS 的高遗传风险与继发 CAD 和糖尿病的风险增加以及血浆蛋白质组组成的改变有关。有必要对已确定的蛋白质及其作为药物靶点的潜在作用进行进一步研究。
{"title":"Genetic Susceptibility to Hidradenitis Suppurativa and Predisposition to Cardiometabolic Disease.","authors":"Valdemar Wendelboe Nielsen, Oliver Bundgaard Vad, Nikolaj Holgersen, Christian Paludan-Müller, Laia Meseguer Monfort, Astrid Filt Beyer, Gregor Borut Ernst Jemec, Rune Kjærsgaard Andersen, Alexander Egeberg, Jacob P Thyssen, Jesper Hastrup Svendsen, Nana Aviaaja Lippert Rosenø, Peter Riis Hansen, Simon Francis Thomsen, Morten Salling Olesen","doi":"10.1001/jamadermatol.2024.3779","DOIUrl":"10.1001/jamadermatol.2024.3779","url":null,"abstract":"<p><strong>Importance: </strong>Hidradenitis suppurativa (HS) is associated with an increased prevalence of cardiovascular diseases compared with the general population. Any association between polygenic risk for HS, risk of incident cardiometabolic outcomes, and the plasma proteome is unclear.</p><p><strong>Objective: </strong>To investigate the genetic correlation between HS and cardiometabolic disease.</p><p><strong>Design, setting, and participants: </strong>This cohort study used a polygenic risk score (PRS) for HS to examine the risks of coronary artery disease (CAD) and diabetes and identify changes in the plasma proteome in individuals of European ancestry from the UK Biobank. Participants were enrolled from January 1, 2006, to December 31, 2010. End of follow-up was January 1, 2023. Correlations were assessed between HS susceptibility and cardiometabolic traits using linkage disequilibrium score regression. Odds ratios were assessed in logistic regressions. The risk of incident CAD and diabetes was estimated in cause-specific survival models designed as time-to-event analyses.</p><p><strong>Exposure: </strong>The PRS for HS.</p><p><strong>Main outcomes and measures: </strong>Main outcomes were CAD and diabetes diagnosis measured by logistic regressions and incident disease measured by Cox proportional hazards regression models adjusted for sex, age, body mass index, and smoking status.</p><p><strong>Results: </strong>The study included 391 481 individuals (median [IQR] age, 58 [51-64] years; 209 235 [53%] female). Genetic variants for HS correlated significantly with variants associated with CAD, diabetes, and plasma levels of high-density lipoprotein cholesterol, triglycerides, and C-reactive protein. Compared with the low-risk group, a high PRS for HS (≥75th percentile) conferred odds ratios of 1.09 (95% CI, 1.06-1.12; P < .001) for CAD and 1.13 (95% CI, 1.10-1.17; P < .001) for diabetes. Estimates remained consistent when examining only incident CAD and diabetes. The PRS for HS was significantly associated with altered expression of 58 plasma proteins. Integrating this proteomic profile and the PRS for HS in a machine learning model improved prediction of CAD and diabetes compared with a reference model based on sex, age, and body mass index.</p><p><strong>Conclusions and relevance: </strong>These findings suggest that a high genetic risk of HS is associated with increased risk of subsequent CAD and diabetes and altered composition of the plasma proteome. Additional investigation into the identified proteins and their potential roles as drug targets is warranted.</p>","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":null,"pages":null},"PeriodicalIF":11.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11465120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Racial and Ethnic Differences in the Risk of Second Primary Melanoma. 二次原发性黑色素瘤风险的种族和民族差异。
IF 11.5 1区 医学 Q1 DERMATOLOGY Pub Date : 2024-10-09 DOI: 10.1001/jamadermatol.2024.3450
Shoshana Zhang, Vishal R Patel, Jennifer C Spencer, Alex B Haynes, Adewole S Adamson
{"title":"Racial and Ethnic Differences in the Risk of Second Primary Melanoma.","authors":"Shoshana Zhang, Vishal R Patel, Jennifer C Spencer, Alex B Haynes, Adewole S Adamson","doi":"10.1001/jamadermatol.2024.3450","DOIUrl":"10.1001/jamadermatol.2024.3450","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":null,"pages":null},"PeriodicalIF":11.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11465117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relative, Absolute, and Excess Risk of Second Primary Melanomas Among Multiple Racial and Ethnic Groups-Analysis of Rare Events. 多个种族和人种群体罹患第二原发性黑色素瘤的相对风险、绝对风险和超额风险--罕见事件分析。
IF 11.5 1区 医学 Q1 DERMATOLOGY Pub Date : 2024-10-09 DOI: 10.1001/jamadermatol.2024.3551
Mya L Roberson, Ivo Abraham
{"title":"Relative, Absolute, and Excess Risk of Second Primary Melanomas Among Multiple Racial and Ethnic Groups-Analysis of Rare Events.","authors":"Mya L Roberson, Ivo Abraham","doi":"10.1001/jamadermatol.2024.3551","DOIUrl":"https://doi.org/10.1001/jamadermatol.2024.3551","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":null,"pages":null},"PeriodicalIF":11.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seborrheic Dermatitis. 脂溢性皮炎。
IF 11.5 1区 医学 Q1 DERMATOLOGY Pub Date : 2024-10-09 DOI: 10.1001/jamadermatol.2024.1074
Tejesh S Patel, Yoseph Dalia
{"title":"Seborrheic Dermatitis.","authors":"Tejesh S Patel, Yoseph Dalia","doi":"10.1001/jamadermatol.2024.1074","DOIUrl":"https://doi.org/10.1001/jamadermatol.2024.1074","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":null,"pages":null},"PeriodicalIF":11.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary Cutaneous Nocardiosis. 原发性皮肤诺卡氏杆菌病
IF 11.5 1区 医学 Q1 DERMATOLOGY Pub Date : 2024-10-02 DOI: 10.1001/jamadermatol.2024.3834
Mingjia Hu, Fangfang Bao, Furen Zhang
{"title":"Primary Cutaneous Nocardiosis.","authors":"Mingjia Hu, Fangfang Bao, Furen Zhang","doi":"10.1001/jamadermatol.2024.3834","DOIUrl":"https://doi.org/10.1001/jamadermatol.2024.3834","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":null,"pages":null},"PeriodicalIF":11.5,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bullous Pemphigoid Severity and Levels of Antibodies to BP180 and BP230: A Systematic Review and Meta-Analysis. 大疱性类天疱疮的严重程度与 BP180 和 BP230 的抗体水平:系统回顾与元分析》。
IF 11.5 1区 医学 Q1 DERMATOLOGY Pub Date : 2024-10-02 DOI: 10.1001/jamadermatol.2024.3425
Po-Yi Chou, Chia-Ling Yu, Chiao-Ni Wen, Yu-Kang Tu, Ching-Chi Chi

Importance: The correlation between serum levels of autoantibodies against bullous pemphigoid (BP) antigens 180 (BP180) and 230 (BP230) with BP disease severity is unclear.

Objective: To investigate the correlation of anti-BP180 and anti-BP230 immunoglobulin G (IgG) antibody levels with BP disease severity.

Data sources: A search was performed of the Cochrane Central Register of Controlled Trials, Embase, and PubMed databases from their respective inception to April 11, 2024.

Study selection: Studies evaluating the correlation between serum levels of anti-BP180 or anti-BP230 IgG measured using enzyme-linked immunosorbent assay (ELISA) and disease severity assessed per the Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) or BP Disease Area Index (BPDAI) were included. No language or geographic restrictions were imposed. Nearly 0.4% of initially identified studies met the selection criteria.

Data extraction and synthesis: One researcher extracted data and another researcher confirmed data. The risk of bias was independently assessed by these researchers using the Quality Assessment of Diagnostic Accuracy Studies 2 tool, with discrepancies resolved by discussion with a third researcher. A random-effects model meta-analysis and a subgroup analysis were conducted based on the ELISA kit manufacturers.

Main outcomes and measures: Pooled correlation coefficients of antibody levels with ABSIS and BPDAI.

Results: In all, 14 studies with 1226 participants were analyzed. The risk of bias of included studies was generally low. The meta-analysis found anti-BP180 autoantibody levels showed moderate correlation with objective BPDAI (r = 0.56; 95% CI, 0.46-0.64) at baseline, strong correlation (r = 0.63; 95% CI, 0.39-0.79) at 3-month follow-up, and moderate correlation (r = 0.53; 95% CI, 0.25-0.72) at 6-month follow-up. Anti-BP180 autoantibody levels also showed moderate correlation (r = 0.52; 95% CI, 0.39-0.62) with ABSIS at baseline, strong correlation (r = 0.62; 95% CI, 0.39-0.79) at 3-month follow-up, and moderate correlation (r = 0.53; 95% CI, 0.25-0.72) at 6-month follow-up. By contrast, anti-BP230 autoantibody levels showed no association with objective BPDAI and ABSIS at diagnosis and follow-up. The subgroup analysis found similar results when using different ELISA kits.

Conclusions and relevance: The findings of this systematic review and meta-analysis indicated that anti-BP180 autoantibody levels may serve as an adjunctive tool for monitoring BP disease severity and guiding clinical care for patients with BP.

重要性:针对大疱性类天疱疮(BP)抗原180(BP180)和230(BP230)的血清自身抗体水平与BP疾病严重程度之间的相关性尚不明确:研究抗 BP180 和抗 BP230 免疫球蛋白 G (IgG) 抗体水平与 BP 疾病严重程度的相关性:研究选择:研究筛选:纳入了评估使用酶联免疫吸附试验(ELISA)测定的血清抗 BP180 或抗 BP230 IgG 水平与根据自身免疫性大疱性皮肤病强度评分(ABSIS)或 BP 疾病面积指数(BPDAI)评估的疾病严重程度之间相关性的研究。没有语言或地域限制。在初步确定的研究中,近 0.4% 的研究符合筛选标准:一名研究人员提取数据,另一名研究人员确认数据。偏倚风险由这些研究人员使用诊断准确性研究质量评估 2 工具进行独立评估,不一致之处由第三位研究人员讨论解决。根据ELISA试剂盒生产商进行了随机效应模型荟萃分析和亚组分析:抗体水平与 ABSIS 和 BPDAI 的汇总相关系数:结果:共分析了14项研究,1226名参与者。纳入研究的偏倚风险普遍较低。荟萃分析发现,抗 BP180 自身抗体水平与客观 BPDAI 在基线时呈中度相关(r = 0.56;95% CI,0.46-0.64),在 3 个月随访时呈强相关(r = 0.63;95% CI,0.39-0.79),在 6 个月随访时呈中度相关(r = 0.53;95% CI,0.25-0.72)。抗 BP180 自身抗体水平在基线时与 ABSIS 也呈中度相关(r = 0.52;95% CI,0.39-0.62),随访 3 个月时呈强相关(r = 0.62;95% CI,0.39-0.79),随访 6 个月时呈中度相关(r = 0.53;95% CI,0.25-0.72)。相比之下,抗 BP230 自身抗体水平与诊断和随访时的客观 BPDAI 和 ABSIS 没有关联。亚组分析发现,使用不同的酶联免疫吸附试剂盒得出的结果相似:本系统综述和荟萃分析的结果表明,抗 BP180 自身抗体水平可作为监测 BP 疾病严重程度和指导 BP 患者临床治疗的辅助工具。
{"title":"Bullous Pemphigoid Severity and Levels of Antibodies to BP180 and BP230: A Systematic Review and Meta-Analysis.","authors":"Po-Yi Chou, Chia-Ling Yu, Chiao-Ni Wen, Yu-Kang Tu, Ching-Chi Chi","doi":"10.1001/jamadermatol.2024.3425","DOIUrl":"10.1001/jamadermatol.2024.3425","url":null,"abstract":"<p><strong>Importance: </strong>The correlation between serum levels of autoantibodies against bullous pemphigoid (BP) antigens 180 (BP180) and 230 (BP230) with BP disease severity is unclear.</p><p><strong>Objective: </strong>To investigate the correlation of anti-BP180 and anti-BP230 immunoglobulin G (IgG) antibody levels with BP disease severity.</p><p><strong>Data sources: </strong>A search was performed of the Cochrane Central Register of Controlled Trials, Embase, and PubMed databases from their respective inception to April 11, 2024.</p><p><strong>Study selection: </strong>Studies evaluating the correlation between serum levels of anti-BP180 or anti-BP230 IgG measured using enzyme-linked immunosorbent assay (ELISA) and disease severity assessed per the Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) or BP Disease Area Index (BPDAI) were included. No language or geographic restrictions were imposed. Nearly 0.4% of initially identified studies met the selection criteria.</p><p><strong>Data extraction and synthesis: </strong>One researcher extracted data and another researcher confirmed data. The risk of bias was independently assessed by these researchers using the Quality Assessment of Diagnostic Accuracy Studies 2 tool, with discrepancies resolved by discussion with a third researcher. A random-effects model meta-analysis and a subgroup analysis were conducted based on the ELISA kit manufacturers.</p><p><strong>Main outcomes and measures: </strong>Pooled correlation coefficients of antibody levels with ABSIS and BPDAI.</p><p><strong>Results: </strong>In all, 14 studies with 1226 participants were analyzed. The risk of bias of included studies was generally low. The meta-analysis found anti-BP180 autoantibody levels showed moderate correlation with objective BPDAI (r = 0.56; 95% CI, 0.46-0.64) at baseline, strong correlation (r = 0.63; 95% CI, 0.39-0.79) at 3-month follow-up, and moderate correlation (r = 0.53; 95% CI, 0.25-0.72) at 6-month follow-up. Anti-BP180 autoantibody levels also showed moderate correlation (r = 0.52; 95% CI, 0.39-0.62) with ABSIS at baseline, strong correlation (r = 0.62; 95% CI, 0.39-0.79) at 3-month follow-up, and moderate correlation (r = 0.53; 95% CI, 0.25-0.72) at 6-month follow-up. By contrast, anti-BP230 autoantibody levels showed no association with objective BPDAI and ABSIS at diagnosis and follow-up. The subgroup analysis found similar results when using different ELISA kits.</p><p><strong>Conclusions and relevance: </strong>The findings of this systematic review and meta-analysis indicated that anti-BP180 autoantibody levels may serve as an adjunctive tool for monitoring BP disease severity and guiding clinical care for patients with BP.</p>","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":null,"pages":null},"PeriodicalIF":11.5,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors Driving the Risk of Cognitive Impairment in Children With Atopic Dermatitis-Reply. 特应性皮炎患儿认知障碍风险的驱动因素--反应。
IF 11.5 1区 医学 Q1 DERMATOLOGY Pub Date : 2024-10-02 DOI: 10.1001/jamadermatol.2024.2971
Emily Z Ma, Sarah Radtke, Joy Wan
{"title":"Factors Driving the Risk of Cognitive Impairment in Children With Atopic Dermatitis-Reply.","authors":"Emily Z Ma, Sarah Radtke, Joy Wan","doi":"10.1001/jamadermatol.2024.2971","DOIUrl":"https://doi.org/10.1001/jamadermatol.2024.2971","url":null,"abstract":"","PeriodicalId":14734,"journal":{"name":"JAMA dermatology","volume":null,"pages":null},"PeriodicalIF":11.5,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
JAMA dermatology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1