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Change in Author Name. 更改作者名称。
IF 11 1区 医学 Q1 DERMATOLOGY Pub Date : 2026-02-01 DOI: 10.1001/jamadermatol.2025.5605
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引用次数: 0
Generalized Atrophic Papules and Acute Abdominal Pain. 全身性萎缩性丘疹和急性腹痛。
IF 11 1区 医学 Q1 DERMATOLOGY Pub Date : 2026-02-01 DOI: 10.1001/jamadermatol.2025.5170
Chirag Vasavda, Birgitta Schmidt, Pierre-Olivier Grenier
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引用次数: 0
Change to Open Access. 更改为开放获取。
IF 11 1区 医学 Q1 DERMATOLOGY Pub Date : 2026-02-01 DOI: 10.1001/jamadermatol.2026.0056
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引用次数: 0
A Nonhealing Ulceration of the Hand. 手部溃疡无法愈合。
IF 11 1区 医学 Q1 DERMATOLOGY Pub Date : 2026-02-01 DOI: 10.1001/jamadermatol.2025.4849
Katelin R Ross, Elijah Horesh, Alex G Ortega-Loayza
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引用次数: 0
Demodicosis and Ivermectin-Associated Mazzotti-Like Reactions After Hematopoietic Cell Transplant. 造血细胞移植后蠕虫病和伊维菌素相关的mazzotti样反应。
IF 11 1区 医学 Q1 DERMATOLOGY Pub Date : 2026-02-01 DOI: 10.1001/jamadermatol.2025.4630
Jennifer Strong, Yoshine Saito, Winnie Trang, Andrea Beri, Alexandra Firek, Steven Mario Munoz, Dennis D Hickstein, Steven Z Pavletic, Richard W Childs, Dimana Dimitrova, Jennifer A Kanakry, Christopher G Kanakry, Edward W Cowen, Leslie Castelo-Soccio, Isaac Brownell
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引用次数: 0
Validation of International Classification of Diseases Codes for Dermatologic Conditions: A Systematic Review. 国际皮肤病疾病分类代码的验证:系统综述。
IF 11 1区 医学 Q1 DERMATOLOGY Pub Date : 2026-02-01 DOI: 10.1001/jamadermatol.2025.5268
Debby Cheng, Nora Bensellam, Katherine Sanchez, Aurore D Zhang, Ursula Biba, Sherry Ershadi, Samantha Gregoire, Nikki Zangenah, Lorena A Acevedo-Fontanez, Anne Fladger, Nicholas Theodosakis, Arash Mostaghimi, John S Barbieri
<p><strong>Importance: </strong>Accurate classification of dermatologic conditions using International Classification of Diseases (ICD) codes is essential for research that uses large administrative datasets. Misclassification can be associated with biased epidemiologic estimates and misleading conclusions in population-based studies.</p><p><strong>Objective: </strong>To systematically identify and evaluate validated classification approaches for dermatologic conditions using ICD codes in US-based administrative, claims, or electronic health record data.</p><p><strong>Evidence review: </strong>A systematic review was conducted that was registered with PROSPERO (CRD420250654233) and reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive search of Ovid MEDLINE, Embase, Web of Science, and CINAHL was conducted for studies published from January 1, 2000, to October 21, 2025. The data were analyzed in October 2025. Eligible studies evaluated International Classification of Diseases, Ninth Revision (ICD-9) or International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) codes used to identify dermatologic conditions in US-based datasets and reported at least 1 classification metric (eg, positive predictive value). To minimize selection and extraction bias, all screening and data extraction were performed independently by 2 reviewers, with discrepancies resolved by consensus.</p><p><strong>Findings: </strong>A total of 59 studies met inclusion criteria. Most reported positive predictive value, with few reporting sensitivity or specificity. Classification accuracy varied widely by condition and coding strategy. Studies included inflammatory and autoimmune conditions (eg, acne vulgaris, perioral dermatitis, psoriasis, palmoplantar pustulosis, hidradenitis suppurativa, atopic dermatitis, prurigo nodularis, dermatomyositis, cutaneous lupus erythematosus, pyoderma gangrenosum, cutaneous sarcoidosis, pemphigus, pemphigoid, granuloma annulare, alopecia areata, and vitiligo), actinic keratosis and skin cancer, pigmentary and hair disorders (eg, androgenic alopecia, cicatricial alopecia, lichen planopilaris, and melasma), drug reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis), and infections (eg, herpes zoster, herpes simplex virus, and cellulitis or abscess). Classification algorithms that incorporated 2 or more codes, dermatologist attribution, or treatment/procedural data often achieved the highest accuracy. Conditions lacking validated algorithms included seborrheic dermatitis, rosacea, fungal infections, and specific alopecia subtypes.</p><p><strong>Conclusions and relevance: </strong>This systematic review provides a summary of the most accurate classification approaches to identify various dermatologic conditions in large administrative datasets. These results may inform study designs when using these datasets. In addition, some com
重要性:使用国际疾病分类(ICD)代码对皮肤病进行准确分类对于使用大型管理数据集的研究至关重要。在基于人群的研究中,错误分类可能与有偏见的流行病学估计和误导性结论有关。目的:系统地识别和评估在美国行政、索赔或电子健康记录数据中使用ICD代码的皮肤疾病的有效分类方法。证据回顾:系统回顾已在PROSPERO注册(CRD420250654233),并根据系统回顾和荟萃分析指南的首选报告项目进行报告。对2000年1月1日至2025年10月21日期间发表的研究进行了Ovid MEDLINE、Embase、Web of Science和CINAHL的综合检索。这些数据是在2025年10月进行分析的。符合条件的研究评估了用于识别美国数据集中皮肤病的国际疾病分类第九版(ICD-9)或国际疾病和相关健康问题统计分类第十版(ICD-10)代码,并报告了至少1个分类指标(例如,阳性预测值)。为了尽量减少选择和提取的偏倚,所有筛选和数据提取均由2位审稿人独立完成,差异通过共识解决。结果:共有59项研究符合纳入标准。大多数报告阳性预测值,很少报告敏感性或特异性。分类精度因条件和编码策略的不同而有很大差异。研究包括炎症和自身免疫性疾病(如:寻常痤疮、口周皮炎、银屑病、掌跖脓肿、化脓性汗腺炎、特应性皮炎、结节性痒疹、皮肌炎、皮肤红斑狼疮、坏疽性脓皮病、皮肤结节病、天疱疮、类天疱疮、环状肉芽肿、斑秃和白癜风)、光化性角化病和皮肤癌、色素和头发疾病(如:雄激素性脱发、瘢痕性脱发、扁平苔藓、和黄褐斑)、药物反应(如史蒂文斯-约翰逊综合征、中毒性表皮坏死松解)和感染(如带状疱疹、单纯疱疹病毒、蜂窝织炎或脓肿)。包含2个或更多代码、皮肤科医生归因或治疗/程序数据的分类算法通常达到最高的准确性。缺乏有效算法的条件包括脂溢性皮炎、酒渣鼻、真菌感染和特定的脱发亚型。结论和相关性:本系统综述总结了在大型管理数据集中识别各种皮肤病的最准确分类方法。当使用这些数据集时,这些结果可以为研究设计提供信息。此外,一些常见情况缺乏经过验证的分类方法,这突出了未来研究的重要领域。随着行政和电子健康记录数据越来越多地支持皮肤病学研究,使用严格验证的算法对于产生可信的发现至关重要。
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引用次数: 0
Successful Treatment of Refractory Severe Localized Scleroderma With Anifrolumab. anfrolumab成功治疗难治性重度局限性硬皮病。
IF 11 1区 医学 Q1 DERMATOLOGY Pub Date : 2026-02-01 DOI: 10.1001/jamadermatol.2025.4606
Rafael Fayos-Gregori, Miguel Mansilla-Polo, Gonzalo Alonso-Fernández, Daniel Martín-Torregrosa, Ignacio Torres-Navarro
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引用次数: 0
Cross-Modal Imaging in Noninvasive Identification of Histologic Features of Skin. 跨模态成像在无创皮肤组织学特征鉴别中的应用。
IF 11 1区 医学 Q1 DERMATOLOGY Pub Date : 2026-02-01 DOI: 10.1001/jamadermatol.2025.4318
Sarah T Arron, Afton Cobb, Lilia M Correa-Selm, Katherine M Given, Manu Jain, David Pilkington, Jennifer Y Wang, Michael Z Wang
<p><strong>Importance: </strong>Histopathology with light microscopy is the reference standard for cellular evaluation of solid tissue, but whether noninvasive cross-modal imaging of skin provides clinicians with comparable histologic information that may assist in clinical decision-making is not well known.</p><p><strong>Objective: </strong>To evaluate safety and effectiveness of cross-modal imaging in obtaining in vivo images, to demonstrate that images align with corresponding skin histopathology, and to evaluate the ability of blinded readers to accurately identify tissue features on cross-modal images.</p><p><strong>Design, setting, and participants: </strong>This observational diagnostic study included 1 visit and follow-up call. Eligible participants were adults aged 18 to 99 years seen for routine care in the outpatient dermatology setting with an indication for lesional skin biopsy. The study was conducted from October 20, 2022, to August 11, 2023, at 2 outpatient dermatology clinics in the US. Cross-modal images and skin biopsy were collected from 1 lesion per participant. Participants were randomized to training (40%) and validation sets (60%). Comparative readers used the training set to evaluate cross-modal images against hematoxylin and eosin histopathology to validate tissue features and train blinded physician readers. Comparative readers developed a performance test with the validation set; blinded physician readers were tested on cross-modal feature identification without access to other participant data.</p><p><strong>Exposure: </strong>All participants underwent cross-modal imaging before biopsy.</p><p><strong>Main outcomes and measures: </strong>The primary end points were 100% comparative reader agreement and validation of cross-modal image tissue features against histopathology and 90% or greater accuracy of blinded physician readers identification of primary tissue features against comparative reader annotation. Secondary end points included accuracy of blinded physician reader identification of secondary features and greater than 90% interrater agreement between blinded physician readers. The safety end point was the number of adverse events observed.</p><p><strong>Results: </strong>A total of 65 participants (median age, 69 [range 20-93] years; 41.5% female and 58.5% male; 1.5% American Indian or Alaska Native; 13.8% Hispanic or Latino; 86.2% not Hispanic or Latino; 98.5% White) underwent cross-modal imaging. Comparative readers achieved 100% consensus and validation of cross-modal histologic features compared with histopathology. Blinded physician reader accuracy for primary histologic features was 96.4% (95% CI, 94.2%-98.7%) and for secondary histologic features was 98.5% (95% CI, 98.1%-98.9%). Interrater agreement among the blinded physician readers was high (Fleiss κ: region, 0.94 [95% CI, 0.87-1.0]; feature, 0.93 [95% CI, 0.88-0.97]). No adverse events were reported.</p><p><strong>Conclusions and relevance: </strong
重要性:光镜下的组织病理学是实体组织细胞评估的参考标准,但皮肤的无创跨模态成像是否能为临床医生提供可辅助临床决策的可比组织学信息尚不清楚。目的:评价跨模态成像获取活体图像的安全性和有效性,证明图像与相应的皮肤组织病理学一致,并评估盲法读者准确识别跨模态图像上组织特征的能力。设计、设置和参与者:这项观察性诊断研究包括1次就诊和随访电话。符合条件的参与者是18至99岁的成年人,在门诊皮肤科进行常规护理,并有病变皮肤活检的指征。该研究于2022年10月20日至2023年8月11日在美国的两家皮肤科门诊诊所进行。从每位参与者的一个病变处采集交叉模态图像和皮肤活检。参与者被随机分配到训练组(40%)和验证组(60%)。比较读者使用训练集来评估针对苏木精和伊红组织病理学的跨模态图像,以验证组织特征和训练盲医读者。比较阅读者开发了一个性能测试与验证集;盲法的医师读者在没有访问其他参与者数据的情况下进行了跨模态特征识别测试。暴露:所有参与者在活检前都进行了交叉模态成像。主要结果和测量:主要终点是100%的比较读者对组织病理学的跨模态图像组织特征的一致性和验证,以及90%或更高的盲法医生读者对比较读者注释的主要组织特征识别的准确性。次要终点包括盲法医师读者对次要特征识别的准确性和盲法医师读者之间大于90%的一致性。安全性终点是观察到的不良事件的数量。结果:共有65名参与者(中位年龄69岁,[范围20-93]岁;41.5%女性,58.5%男性;1.5%美国印第安人或阿拉斯加原住民;13.8%西班牙裔或拉丁裔;86.2%非西班牙裔或拉丁裔;98.5%白人)接受了跨模式成像。与组织病理学相比,比较读者对跨模态组织学特征的一致性和有效性达到100%。盲法医师读者对原发性组织学特征的准确率为96.4% (95% CI, 94.2%-98.7%),对继发性组织学特征的准确率为98.5% (95% CI, 98.1%-98.9%)。盲法医师读者之间的通译一致性很高(Fleiss κ:区域,0.94 [95% CI, 0.87-1.0];特征,0.93 [95% CI, 0.88-0.97])。无不良事件报告。结论和相关性:本研究的结果表明,跨模态成像是安全的,训练有素的医生可以准确地识别跨模态图像上的组织学特征,这与美国食品和药物管理局批准的辅助临床判断的作用是一致的。
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引用次数: 0
Health System Experiences and Care Engagement in Latine Patients With Hidradenitis Suppurativa. 拉丁化脓性汗腺炎患者的卫生系统经验和护理参与。
IF 11 1区 医学 Q1 DERMATOLOGY Pub Date : 2026-02-01 DOI: 10.1001/jamadermatol.2025.5112
Yanel Hernandez, Nathaly Gonzalez, Raveena Ghanshani, Herbert B Castillo Valladares, Erin H Amerson, Haley B Naik, Jennifer L Hsiao, Jennifer James, Sara L Ackerman, Aileen Y Chang

Importance: Latine patients with hidradenitis suppurativa (HS) are reported to experience more severe disease and longer delays to diagnosis compared with White patients with HS.

Objective: To assess the implications of health care system factors in HS care experiences for Latine patients.

Design, setting, and participants: From June 2024 through March 2025, this qualitative study recruited English- and Spanish-language preferring Latine adults diagnosed with HS from dermatology clinics at 2 academic medical centers and 2 county hospitals in California. Deidentified audio recordings were transcribed and translated from semistructured interviews conducted by a bilingual Latine interviewer.

Main outcomes and measures: After transcripts were coded, a thematic analysis was conducted to develop themes that captured the range of participants' experiences, attitudes, behaviors, and beliefs related to receiving health care for HS and implementing HS care plans throughout their HS care journey, including the time before they received care from their current dermatologist.

Results: Among the 24 Latine patients included in the analysis, the median (IQR) age was 37.5 (32.75-44.25) years, 17 (71%) were female, 11 (46%) preferred Spanish, and 19 (79%) had Hurley stage 2 or 3 disease. Three themes were developed. First, unaddressed wound care and pain management burdens patients with self-directed care, with 2 subthemes: (1) insufficient guidance for patients' wound care and pain management and (2) self-directed care in response to limited health care system support for pain management and wound care creates personal burden. Second, perceived discrimination during dermatology visits leads to avoidance of care. Third, patient-centered care remains a challenge with phone or video interpreter-mediated communication.

Conclusions and relevance: In this study, many Latine participants with HS experienced unaddressed wound care and pain management needs, perceived discrimination, and challenges with interpreter-mediated communication during care with a dermatologist. Interventions are needed to prioritize wound care and pain management in multidisciplinary care plans and optimize patient-centered HS care.

重要性:据报道,与白人患者相比,拉丁裔化脓性汗腺炎(HS)患者病情更严重,诊断延误时间更长。目的:评估卫生保健系统因素对拉丁裔患者HS护理经历的影响。设计、环境和参与者:从2024年6月到2025年3月,本定性研究从加利福尼亚州2个学术医疗中心和2个县医院的皮肤科诊所招募了英语和西班牙语倾向于诊断为HS的拉丁成年人。一名双语拉丁语采访者对半结构化访谈进行了录音转录和翻译。主要结果和措施:转录记录编码后,进行主题分析,以制定主题,以捕获参与者的经历、态度、行为和信念范围,这些主题与接受HS保健和在整个HS护理过程中实施HS护理计划有关,包括他们接受当前皮肤科医生护理之前的时间。结果:纳入分析的24例拉丁患者中位(IQR)年龄为37.5(32.75-44.25)岁,女性17例(71%),偏爱西班牙语11例(46%),19例(79%)患有Hurley 2期或3期疾病。会议发展了三个主题。首先,未解决的伤口护理和疼痛管理给自我指导护理的患者带来了负担,其中有两个次要主题:(1)对患者伤口护理和疼痛管理的指导不足;(2)自我指导护理应对卫生保健系统对疼痛管理和伤口护理的有限支持,造成个人负担。其次,在皮肤科就诊时的感知歧视导致回避护理。第三,以病人为中心的护理仍然是电话或视频翻译媒介沟通的挑战。结论和相关性:在本研究中,许多患有HS的拉丁裔参与者经历了未解决的伤口护理和疼痛管理需求,感知到歧视,以及在与皮肤科医生护理期间口译员介导的沟通方面的挑战。需要采取干预措施,在多学科护理计划中优先考虑伤口护理和疼痛管理,并优化以患者为中心的HS护理。
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引用次数: 0
Errors in Byline and Figures 3 and 4. 署名和图3、图4中的错误。
IF 11 1区 医学 Q1 DERMATOLOGY Pub Date : 2026-01-28 DOI: 10.1001/jamadermatol.2025.6203
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引用次数: 0
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JAMA dermatology
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