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Effectiveness of Self-Management Programs Among Athletes With Patellofemoral Pain Syndrome: Protocol for a Systematic Review. 髌骨股骨痛综合征运动员自我管理计划的有效性:系统性回顾协议
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-01 DOI: 10.2196/58340
Ameen Masoudi, Nomzamo Chemane, Ushotanefe Useh, Bashir Bello, Nontembiso Magida

Background: Patellofemoral pain syndrome is a highly prevalent overuse knee injury in athletic populations associated with pain and functional limitations, exacerbated by activities such as running, pivoting, cycling, and jumping. Self-management programs empowering athletes to take an active role in controlling their symptoms for chronic musculoskeletal conditions such as patellofemoral pain syndrome have grown in popularity. However, the efficacy of self-management programs specifically for athletes with patellofemoral pain syndrome is unclear due to limited and heterogeneous evidence.

Objective: The systematic review study will evaluate the effectiveness of self-management programs on pain and function, in athletes with patellofemoral pain syndrome.

Methods: PubMed/MEDLINE, Cochrane Library, CINAHL (Cumulative Index to Nursing and Allied Health Literature), and PsycINFO databases will be systematically searched using terms related to "patellofemoral pain syndrome," "self-management," and "athletes." Interventional studies that are randomized and nonrandomized controlled trials will be included, comparing self-management programs to other treatments or control conditions among athletes with patellofemoral pain syndrome. Four reviewers will independently screen studies, extract data using the COVIDENCE software, and assess the quality of the study and evidence using the Pedro scale of risk of bias tool and GRADE approach, respectively. If feasible, a meta-analysis will be performed using the RevMan (version 5.4; the Cochrane Collaboration).

Results: The systematic review is currently in the search phase, with the authors refining search strings for the selected databases. The final search strings are expected to be ready by March 2024, and the review is projected to be completed by July 2024.

Conclusions: This systematic review protocol outlines a rigorous methodology for evaluating the effectiveness of self-management programs among athletes with patellofemoral pain syndrome. The findings will inform clinical practice and guide the development of tailored interventions to optimize outcomes for athletes with patellofemoral pain syndrome.

Trial registration: PROSPERO CRD42023492746; https://tinyurl.com/c5jze9ca.

International registered report identifier (irrid): PRR1-10.2196/58340.

背景:髌骨股骨痛综合征是运动员群体中一种高发的过度劳损性膝关节损伤,伴有疼痛和功能受限,跑步、转体、骑自行车和跳跃等活动会加剧疼痛和功能受限。自我管理计划使运动员有能力积极控制髌骨股骨疼痛综合征等慢性肌肉骨骼疾病的症状,因此越来越受欢迎。然而,由于证据有限且不尽相同,专门针对髌骨股骨痛综合征运动员的自我管理计划的疗效尚不明确:本系统综述研究将评估自我管理计划对患有髌骨股骨疼痛综合征的运动员的疼痛和功能的有效性:方法:将使用与 "髌骨股关节疼痛综合征"、"自我管理 "和 "运动员 "相关的术语对 PubMed/MEDLINE、Cochrane 图书馆、CINAHL(护理与联合健康文献累积索引)和 PsycINFO 数据库进行系统检索。将纳入随机对照试验和非随机对照试验的干预性研究,对患有髌骨股骨疼痛综合征的运动员的自我管理计划与其他治疗方法或对照条件进行比较。四位评审员将独立筛选研究,使用 COVIDENCE 软件提取数据,并分别使用佩德罗偏倚风险量表工具和 GRADE 方法评估研究和证据的质量。如果可行,将使用 RevMan(5.4 版;Cochrane 协作组织)进行荟萃分析:系统综述目前处于检索阶段,作者正在完善所选数据库的检索字符串。最终的检索字符串预计将于 2024 年 3 月完成,综述预计将于 2024 年 7 月完成:本系统综述协议概述了评估髌骨股骨痛综合征运动员自我管理计划有效性的严格方法。研究结果将为临床实践提供参考,并指导制定有针对性的干预措施,以优化髌骨股骨疼痛综合征运动员的治疗效果:PROSPERO CRD42023492746; https://tinyurl.com/c5jze9ca.International 注册报告标识符 (irrid):prr1-10.2196/58340.
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引用次数: 0
AI-Supported Digital Microscopy Diagnostics in Primary Health Care Laboratories: Protocol for a Scoping Review. 初级卫生保健实验室的人工智能支持数字显微镜诊断:范围审查协议》。
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-01 DOI: 10.2196/58149
Joar von Bahr, Vinod Diwan, Andreas Mårtensson, Nina Linder, Johan Lundin

Background: Digital microscopy combined with artificial intelligence (AI) is increasingly being implemented in health care, predominantly in advanced laboratory settings. However, AI-supported digital microscopy could be especially advantageous in primary health care settings, since such methods could improve access to diagnostics via automation and lead to a decreased need for experts on site. To our knowledge, no scoping or systematic review had been published on the use of AI-supported digital microscopy within primary health care laboratories when this scoping review was initiated. A scoping review can guide future research by providing insights to help navigate the challenges of implementing these novel methods in primary health care laboratories.

Objective: The objective of this scoping review is to map peer-reviewed studies on AI-supported digital microscopy in primary health care laboratories to generate an overview of the subject.

Methods: A systematic search of the databases PubMed, Web of Science, Embase, and IEEE will be conducted. Only peer-reviewed articles in English will be considered, and no limit on publication year will be applied. The concept inclusion criteria in the scoping review include studies that have applied AI-supported digital microscopy with the aim of achieving a diagnosis on the subject level. In addition, the studies must have been performed in the context of primary health care laboratories, as defined by the criteria of not having a pathologist on site and using simple sample preparations. The study selection and data extraction will be performed by 2 independent researchers, and in the case of disagreements, a third researcher will be involved. The results will be presented in a table developed by the researchers, including information on investigated diseases, sample collection, preparation and digitization, AI model used, and results. Furthermore, the results will be described narratively to provide an overview of the studies included. The proposed methodology is in accordance with the JBI methodology for scoping reviews.

Results: The scoping review was initiated in January 2023, and a protocol was published in the Open Science Framework in January 2024. The protocol was completed in March 2024, and the systematic search will be performed after the protocol has been peer reviewed. The scoping review is expected to be finalized by the end of 2024.

Conclusions: A systematic review of studies on AI-supported digital microscopy in primary health care laboratories is anticipated to identify the diseases where these novel methods could be advantageous, along with the shared challenges encountered and approaches taken to address them.

International registered report identifier (irrid): PRR1-10.2196/58149.

背景:结合人工智能(AI)的数码显微技术正越来越多地应用于医疗保健领域,主要是在高级实验室环境中。然而,人工智能支持的数字显微镜技术在初级医疗机构中尤其具有优势,因为这种方法可以通过自动化提高诊断的可及性,从而减少对现场专家的需求。据我们所知,在启动本范围界定综述时,还没有关于在初级卫生保健实验室中使用人工智能支持的数码显微镜的范围界定或系统综述。范围界定综述可以为未来的研究提供指导,提供见解,帮助应对在初级卫生保健实验室实施这些新方法所面临的挑战:本范围界定综述的目的是对初级卫生保健实验室中人工智能支持的数字显微镜的同行评审研究进行摸底,以便对该主题进行概述:方法:将对 PubMed、Web of Science、Embase 和 IEEE 等数据库进行系统检索。只考虑同行评审过的英文文章,不限制发表年份。范围界定审查的概念纳入标准包括应用人工智能支持的数字显微镜进行研究,目的是实现学科层面的诊断。此外,这些研究必须是在初级卫生保健实验室中进行的,其标准是现场没有病理学家并使用简单的样本制备方法。研究选择和数据提取将由两名独立研究人员进行,如果出现分歧,将由第三名研究人员参与。研究结果将以研究人员制定的表格形式呈现,包括所调查疾病的信息、样本采集、制备和数字化、所使用的人工智能模型以及结果。此外,还将对结果进行叙述性说明,以提供所纳入研究的概况。建议采用的方法与 JBI 的范围界定审查方法一致:范围界定审查于 2023 年 1 月启动,并于 2024 年 1 月在开放科学框架中发布了审查协议。协议于 2024 年 3 月完成,系统检索将在协议通过同行评审后进行。范围界定审查预计将于 2024 年底完成:对初级卫生保健实验室中人工智能支持的数字显微镜的研究进行系统综述,预计将确定这些新方法可能具有优势的疾病,以及遇到的共同挑战和解决这些挑战的方法:PRR1-10.2196/58149。
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引用次数: 0
Structural Influences on Methamphetamine Use Among Black Sexual Minority Men (HISTORY Study): Protocol for a Longitudinal Cohort Study. 黑人性少数群体男性使用甲基苯丙胺的结构性影响因素(HISTORY 研究):纵向队列研究协议》。
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-10-31 DOI: 10.2196/63761
Samuel C O Opara, Sabriya L Linton, Brian W Weir, Natalie D Crawford, David P Holland, Antonio Newman, McKinsey Bullock, Marcus O Reed, Srija Dutta, Kamini Doraivelu, Charles Stephens, Justin C Smith, Yeeli Mui, Sophia A Hussen

Background: Sexual minority men are disproportionately affected by methamphetamine use, with recent studies suggesting an increase in use specifically among Black sexual minority men. Black sexual minority men face unique structural barriers to achieving optimal health. Given its harmful effects, and in light of existing health disparities, an increase in methamphetamine use among Black sexual minority men poses a significant public health concern.

Objective: The Health Impacts and Struggles to Overcome the Racial Discrimination of Yesterday (HISTORY) study is investigating the potential impacts of exposure to the census tract-level structural racism and discrimination (SRD) on methamphetamine use among Black sexual minority men in Atlanta, Georgia, and will identify intervention targets to improve prevention and treatment of methamphetamine use in this population.

Methods: This study uses a mixed methods and multilevel design over a 5-year period and incorporates participatory approaches. Individual-level quantitative data will be collected from a community-based cohort of Black sexual minority men (N=300) via periodic assessment surveys, ecological momentary assessments, and medical record abstractions. Census tract-level measures of SRD will be constructed using publicly available administrative data. Qualitative data collection will include longitudinal, repeated in-depth interviews with a subset (n=40) of study participants. Finally, using a participatory group model-building process, we will build on our qualitative and quantitative data to generate causal maps of SRD and methamphetamine use among Black sexual minority men, which in turn will be translated into actionable recommendations for structural intervention.

Results: Enrollment in the HISTORY study commenced in March 2023 and is anticipated to be completed by November 2024.

Conclusions: The HISTORY study will serve as a crucial background upon which future structural interventions can be built, to mitigate the effects of methamphetamine use and SRD among Black sexual minority men.

International registered report identifier (irrid): DERR1-10.2196/63761.

背景:性少数群体男性受使用甲基苯丙胺的影响尤为严重,最近的研究表明,黑人性少数群体男性使用甲基苯丙胺的情况尤其增多。黑人性少数群体男性在实现最佳健康方面面临着独特的结构性障碍。鉴于甲基苯丙胺的有害影响,并考虑到现有的健康差异,黑人性少数群体男性使用甲基苯丙胺的增加构成了一个重大的公共健康问题:健康影响和克服昨日种族歧视的斗争(HISTORY)研究正在调查人口普查区一级的结构性种族主义和歧视(SRD)对佐治亚州亚特兰大黑人性少数群体男性吸食甲基苯丙胺的潜在影响,并将确定干预目标,以改善对该人群吸食甲基苯丙胺的预防和治疗:本研究采用混合方法和多层次设计,为期 5 年,并采用参与式方法。个人层面的定量数据将通过定期评估调查、生态学瞬间评估和病历摘要等方式从黑人性少数群体男性(人数=300)的社区队列中收集。人口普查区一级的 SRD 指标将使用公开的行政数据构建。定性数据收集将包括对研究参与者的一个子集(人数=40)进行纵向、重复的深度访谈。最后,我们将利用参与式小组模型构建过程,在定性和定量数据的基础上,生成黑人性少数群体男性 SRD 和甲基苯丙胺使用的因果关系图,进而转化为可操作的结构性干预建议:HISTORY 研究于 2023 年 3 月开始注册,预计将于 2024 年 11 月完成:HISTORY研究将作为未来结构性干预的重要背景,以减轻黑人性少数群体男性使用甲基苯丙胺和SRD的影响:DERR1-10.2196/63761。
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引用次数: 0
Misinformation About Climate Change and Related Environmental Events on Social Media: Protocol for a Scoping Review. 社交媒体上关于气候变化和相关环境事件的错误信息:范围界定审查议定书》。
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-10-31 DOI: 10.2196/59345
Maryline Vivion, Valérie Trottier, Ève Bouhêlier, Isabelle Goupil-Sormany, Thierno Diallo
<p><strong>Background: </strong>Climate change and related environmental events represent major global challenges and are often accompanied by the spread of misinformation on social media. According to previous reviews, the dissemination of this misinformation on various social media platforms requires deeper exploration. Moreover, the findings reported applied mainly to the context of the United States, limiting the possibility of extending the results to other settings.</p><p><strong>Objective: </strong>This study aims to assess the current state of knowledge about misinformation concerning climate change and related environmental events that are circulating on social media. More specifically, we will explore past and current themes, actors, and sources, and the dissemination of this misinformation within the Canadian context.</p><p><strong>Methods: </strong>This scoping review protocol follows the methodological approach developed by Arksey and O'Malley and advanced by Levac, complemented by the PRISMA-ScR (Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews) checklist and the best practice guidance for the development of scoping review protocols. Following the identification of the research questions and assisted by a specialized librarian, we developed search strategies for selected bibliographic databases (MEDLINE, Embase, Web of Science, and GreenFILE) and for gray literature (Google and pertinent databases) searches. Bibliographic and gray literature will be searched to identify relevant publications. In total, 2 members of our team will use the review software Covidence (Veritas Health Innovation) to independently select publications to include in the review. Publications specifically addressing our research questions, peer-reviewed, evidence-based, and published from January 1, 2000, in the full-text version in English or French will be included. Data will be extracted from the included publications to chart, among other items, the years of publication, geographic areas, themes, actors, and sources of the climate change-related misinformation and conclusions reported. Our team will then synthesize the extracted data to articulate the current state of knowledge relating to our research inquiries.</p><p><strong>Results: </strong>The research questions were identified in January 2024. The search strategies were developed from January to March 2024 for MEDLINE, Embase, and Web of Science and in July 2024 for GreenFILE and gray literature. MEDLINE, Embase, and Web of Science searches were launched on March 26, 2024. The first of 2 rounds of selection of publications identified through these databases was achieved in April 2024.</p><p><strong>Conclusions: </strong>This protocol will enable us to identify the evolution of themes, actors, and sources of misinformation regarding climate change and related environmental events on social media, including the latest platforms, and to potentially identify
背景:气候变化和相关环境事件是全球性的重大挑战,往往伴随着错误信息在社交媒体上的传播。根据以往的评论,需要对这些错误信息在各种社交媒体平台上的传播进行更深入的探讨。此外,报告的研究结果主要适用于美国的情况,限制了将结果推广到其他环境的可能性:本研究旨在评估社交媒体上流传的有关气候变化和相关环境事件的错误信息的知识现状。更具体地说,我们将探讨过去和当前的主题、参与者和来源,以及这些错误信息在加拿大范围内的传播情况:本范围界定综述协议遵循 Arksey 和 O'Malley 开发的、由 Levac 推进的方法论方法,并辅以 PRISMA-ScR(范围界定综述的系统综述和 Meta 分析扩展首选报告项目)核对表和范围界定综述协议开发最佳实践指南。确定研究问题后,在专业图书管理员的协助下,我们为选定的书目数据库(MEDLINE、Embase、Web of Science 和 GreenFILE)和灰色文献(Google 和相关数据库)制定了检索策略。我们将对书目文献和灰色文献进行检索,以确定相关出版物。我们团队的两名成员将使用审稿软件 Covidence(Veritas Health Innovation)独立选择要纳入审稿的出版物。我们将收录专门针对我们的研究问题、经过同行评审、以证据为基础、自 2000 年 1 月 1 日起出版的英文或法文全文出版物。我们将从收录的出版物中提取数据,除其他项目外,绘制出与气候变化相关的错误信息和结论的出版年份、地理区域、主题、参与者和来源图表。然后,我们的团队将对提取的数据进行综合,以阐明与我们的研究调查相关的知识现状:研究问题于 2024 年 1 月确定。2024 年 1 月至 3 月制定了 MEDLINE、Embase 和 Web of Science 的检索策略,2024 年 7 月制定了 GreenFILE 和灰色文献的检索策略。MEDLINE、Embase 和 Web of Science 的检索于 2024 年 3 月 26 日启动。2024 年 4 月,对通过这些数据库确定的出版物进行了两轮筛选,并完成了第一轮筛选:该协议将使我们能够确定社交媒体(包括最新平台)上有关气候变化和相关环境事件的错误信息的主题、参与者和来源的演变,并有可能确定加拿大的特殊背景。众所周知,错误信息会破坏应对气候变化的行动和公众支持,因此,我们希望以最新的方式,根据具体情况,有针对性地打击与气候变化有关的错误信息:DERR1-10.2196/59345。
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引用次数: 0
A Real-Life Laboratory Setting for Clinical Practice, Education, and Research in Family Systems Care: Protocol for a Transformational Action Research Study. 家庭系统护理临床实践、教育和研究的真实实验室环境:转型行动研究协议》。
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-10-30 DOI: 10.2196/53090
Evelyn Huber, Erika Harju, Elisabeth Stark, André Fringer, Barbara Preusse-Bleuler
<p><strong>Background: </strong>Burdening health and illness issues such as physical or mental illnesses, accidents, disabilities, and life events such as birth or death influence the health and functioning of families and contribute to the complexity of care and health care costs. Considerable research has confirmed the benefits of a family systems-centered care approach for patients, family caregivers, families, and health care professionals. However, health care professionals face barriers in working with families, such as feeling unprepared. Family systems-centered therapeutic conversations support families' day-to-day coping, resilience, and health. A family systems care unit (FSCU) was recently established as a real-life laboratory at one of the Swiss Universities of Applied Sciences. In this unit, health care professionals offer therapeutic conversations to families and individual family members to support daily symptom management and functioning, soften suffering, and increase health and well-being. These conversations are observed in real time through a 1-way window by other health care professionals, students, and trainees and are recorded with video for research and education. Little is known about how therapeutic conversations contribute to meaningful changes in burdened families and the benefits of vicarious learning in a real-life laboratory setting for family systems care.</p><p><strong>Objective: </strong>In this research program, we aim to deepen our understanding of how therapeutic conversations support families and individuals experiencing burdening health and illness issues and how the FSCU laboratory setting supports the learning of students, clinical trainees, and health care professionals.</p><p><strong>Methods: </strong>Here we apply a transformational action research design, including parallel and subsequent substudies, to advance knowledge and practice in family systems care. Qualitative multiple-case study designs will be used to explore the benefits of therapeutic conversations by analyzing recordings of the therapeutic conversations. The learning processes of students, trainees, and professionals will be investigated with descriptive qualitative study designs based on single and focus group interviews. The data will be analyzed with established coding methods.</p><p><strong>Results: </strong>Therapeutic conversations have been investigated in 3 single-case studies, each involving a sequence of 3 therapeutic conversation units. Data collection regarding the second research question is planned.</p><p><strong>Conclusions: </strong>Preliminary results confirm the therapeutic conversations to support families' coping. This renders the FSCU a setting for ethically sensitive research. This program will not only support the health and well-being of families, but also contribute to relieving the financial and workforce burdens in the health and social care system.</p><p><strong>International registered report identifier (irrid
背景:繁重的健康和疾病问题,如身体或精神疾病、意外事故、残疾以及出生或死亡等生命事件,都会影响家庭的健康和功能,并导致护理的复杂性和医疗费用的增加。大量研究证实,以家庭系统为中心的护理方法对病人、家庭护理者、家人和医护专业人员都有好处。然而,医护专业人员在与家庭合作时会遇到一些障碍,比如感觉没有准备好。以家庭系统为中心的治疗对话有助于家庭的日常应对、恢复能力和健康。最近,瑞士一所应用科学大学建立了一个家庭系统护理单元(FSCU),作为现实生活中的实验室。在这个单位里,医疗保健专业人员为家庭和家庭成员个人提供治疗对话,以支持日常症状管理和功能,减轻痛苦,提高健康和幸福感。其他医护人员、学生和受训人员通过单向窗口实时观察这些对话,并进行录像,用于研究和教育。人们对治疗性对话如何促进负担沉重的家庭发生有意义的变化,以及在家庭系统护理的真实实验室环境中进行替代学习的益处知之甚少:在本研究计划中,我们旨在加深了解治疗性对话如何为遭遇沉重健康和疾病负担问题的家庭和个人提供支持,以及家庭系统护理实验室环境如何为学生、临床受训人员和医疗保健专业人员的学习提供支持。方法:在此,我们采用转化行动研究设计,包括平行研究和后续子研究,以促进家庭系统护理方面的知识和实践。我们将采用定性多案例研究设计,通过分析治疗对话的录音来探索治疗对话的益处。学生、受训人员和专业人员的学习过程将通过基于单人和焦点小组访谈的描述性定性研究设计进行调查。数据将采用既定的编码方法进行分析:在 3 项单一案例研究中对治疗性对话进行了调查,每项研究涉及 3 个治疗性对话单元的序列。目前正在计划收集有关第二个研究问题的数据:初步结果证实,治疗性对话有助于家庭的应对。这使家庭治疗对话单元成为一个具有伦理敏感性的研究环境。这项计划不仅能为家庭的健康和幸福提供支持,还有助于减轻医疗和社会护理系统的财政和劳动力负担:DERR1-10.2196/53090。
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引用次数: 0
Efficacy of a Multimodal Digital Behavior Change Intervention on Lifestyle Behavior, Cardiometabolic Biomarkers, and Medical Expenditure: Protocol for a Randomized Controlled Trial. 多模式数字化行为改变干预对生活方式、心脏代谢生物标志物和医疗支出的影响:随机对照试验方案》。
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-10-30 DOI: 10.2196/50378
Sakeina Howard-Wilson, Jack Ching, Sherri Gentile, Martin Ho, Alex Garcia, Didem Ayturk, Peter Lazar, Nova Hammerquist, David McManus, Bruce Barton, Steven Bird, John Moore, Apurv Soni

Background: The US Preventive Services Task Force recommends providers offer individualized healthy behavior interventions for all adults, independent of their risk of cardiovascular disease. While strong evidence exists to support disease-specific programs designed to improve multiple lifestyle behaviors, approaches to adapting these interventions for a broader population are not well established. Digital behavior change interventions (DBCIs) hold promise as a more generalizable and scalable approach to overcome the resource and time limitations that traditional behavioral intervention programs face, especially within an occupational setting.

Objective: We aimed to evaluate the efficacy of a multimodal DBCI on (1) self-reported behaviors of physical activity, nutrition, sleep, and mindfulness; (2) cardiometabolic biomarkers; and (3) chronic disease-related medical expenditure.

Methods: We conducted a 2-arm randomized controlled trial for 12 months among employees of an academic health care facility in the United States. The intervention arm received a scale, a smartphone app, an activity tracker, a video library for healthy behavior recommendations, and an on-demand health coach. The control arm received standard employer-provided health and wellness benefits. The primary outcomes of the study included changes in self-reported lifestyle behaviors, cardiometabolic biomarkers, and chronic disease-related medical expenditure. We collected health behavior data via baseline and quarterly web-based surveys, biometric measures via clinic visits at baseline and 12 months, and identified relevant costs through claims datasets.

Results: A total of 603 participants were enrolled and randomized to the intervention (n=300, 49.8%) and control arms (n=303, 50.2%). The average age was 46.7 (SD 11.2) years, and the majority of participants were female (80.3%, n=484), White (85.4%, n=504), and non-Hispanic (90.7%, n=547), with no systematic differences in baseline characteristics observed between the study arms. We observed retention rates of 86.1% (n=519) for completing the final survey and 77.9% (n=490) for attending the exit visit.

Conclusions: This study represents the largest and most comprehensive evaluation of DBCIs among participants who were not selected based on their underlying condition to assess its impact on behavior, cardiometabolic biomarkers, and medical expenditure.

Trial registration: ClinicalTrials.gov NCT04712383; https://clinicaltrials.gov/study/NCT04712383.

International registered report identifier (irrid): RR1-10.2196/50378.

背景:美国预防服务工作组建议医疗服务提供者为所有成年人提供个性化的健康行为干预,而不论其是否有心血管疾病风险。虽然有确凿证据支持旨在改善多种生活方式行为的特定疾病计划,但将这些干预措施应用于更广泛人群的方法尚未得到充分证实。数字行为改变干预(DBCIs)有望成为一种更具普遍性和可扩展性的方法,以克服传统行为干预计划所面临的资源和时间限制,尤其是在职业环境中:我们旨在评估多模式 DBCI 在以下方面的效果:(1)自我报告的体育锻炼、营养、睡眠和正念行为;(2)心脏代谢生物标志物;以及(3)与慢性疾病相关的医疗支出:我们在美国一家学术医疗机构的员工中开展了一项为期 12 个月的双臂随机对照试验。干预组接受量表、智能手机应用程序、活动追踪器、健康行为建议视频库和按需健康指导。对照组则享受雇主提供的标准健康福利。研究的主要结果包括自我报告的生活方式行为、心脏代谢生物标志物和慢性病相关医疗支出的变化。我们通过基线调查和季度网络调查收集健康行为数据,通过基线和 12 个月的门诊测量生物标志物,并通过索赔数据集确定相关费用:共有 603 名参与者注册并随机分配到干预组(300 人,占 49.8%)和对照组(303 人,占 50.2%)。平均年龄为 46.7 岁(标准差 11.2),大多数参与者为女性(80.3%,人数=484)、白人(85.4%,人数=504)和非西班牙裔(90.7%,人数=547),研究臂之间的基线特征没有系统性差异。我们观察到,完成最终调查的保留率为 86.1%(n=519),参加退出访问的保留率为 77.9%(n=490):本研究是对未根据基础疾病选择参与者的 DBCIs 进行的规模最大、最全面的评估,以评估其对行为、心脏代谢生物标志物和医疗支出的影响:试验注册:ClinicalTrials.gov NCT04712383;https://clinicaltrials.gov/study/NCT04712383.International 注册报告标识符 (irrid):RR1-10.2196/50378。
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引用次数: 0
Effects of Injury Registry Data on Policy Making, Hospitalizations, and Mortality: Protocol for a Systematic Review and Meta-Analysis. 伤害登记数据对决策、住院和死亡率的影响:系统回顾和元分析协议》。
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-10-30 DOI: 10.2196/55029
Ana Cláudia Medeiros-de-Souza, Luana Emanuelly Sinhori Lopes, Bruno Zocca de Oliveira, Edna Terezinha Rother, Lucas Reis Correia

Background: Initiated in 2021, a Brazilian project aims to establish a national injury registry, compiling comprehensive data on events and individuals across the country, irrespective of injury severity. The registry integrates information from prehospital and hospital care, diverse health systems lacking interoperability, and sectors such as firefighters and the police. Its primary goal is to enhance health surveillance by providing timely, high-quality information, guiding prevention strategies, and informing policy making. The project still aims to reduce long-term morbidity and mortality associated with injuries.

Objective: A knowledge gap remains regarding the effects of injury registries in relation to policies and injury outcomes. This protocol outlines a systematic review and meta-analysis to answer "What is the effect of implementation and use of injury registry data on policy making, hospitalization, and mortality?"

Methods: The systematic review follows PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, focusing on studies reporting results related to the implementation and use of injury registries, including trauma registries. Outcomes of interest include policy making, hospitalization rates or duration, and mortality. Registries within well-defined administrative boundaries will be included. Data will be collected from PubMed, Embase, Scopus, Web of Science, Lilacs, and references. Records will be independently screened by 2 reviewers, with any disagreements resolved through arbitration by a third reviewer. Homogeneous studies, with 3 or more evaluating the same outcome, may undergo meta-analysis. Subgroup analyses by registry type, injury groups, and other selected variables of interest will be conducted. Sensitivity analysis, risk of bias assessment, publication bias evaluation, and quality appraisal will also be performed.

Results: This systematic review will run from November 2023 to June 2024. No identical review was found. Search strategies were finalized, the bibliographic search started, duplicates were eliminated, and title and abstract screening began. Of 35 studies retrieved, 85 were excluded due to duplication, leaving 50 for selection.

Conclusions: This study is timely, aligning with ongoing national efforts to implement an injury registry. By synthesizing available evidence, we will identify the potential of injury registries to guide the decisions of Brazilian policy makers.

Trial registration: PROSPERO CRD42023481528; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=481528.

International registered report identifier (irrid): PRR1-10.2196/55029.

背景:巴西的一个项目于 2021 年启动,旨在建立一个全国伤害登记处,汇集全国范围内有关事件和个人的全面数据,无论伤害严重程度如何。该登记处整合了来自院前和医院护理、缺乏互操作性的不同医疗系统以及消防员和警察等部门的信息。其主要目标是通过提供及时、高质量的信息,加强健康监测,指导预防策略,并为政策制定提供信息。该项目的目标仍然是降低与伤害相关的长期发病率和死亡率:在伤害登记对政策和伤害结果的影响方面仍存在知识空白。本方案概述了一项系统综述和荟萃分析,旨在回答 "伤害登记数据的实施和使用对政策制定、住院和死亡率有何影响?系统综述遵循 PRISMA(系统综述和荟萃分析的首选报告项目)指南,重点关注与伤害登记处(包括创伤登记处)的实施和使用相关的结果报告研究。关注的结果包括政策制定、住院率或住院时间以及死亡率。将纳入行政区划明确的登记处。数据将从 PubMed、Embase、Scopus、Web of Science、Lilacs 和参考文献中收集。记录将由两名审稿人独立筛选,如有任何分歧,将由第三名审稿人仲裁解决。同质研究,即 3 项或更多评估相同结果的研究,可进行荟萃分析。还将按登记类型、受伤组别和其他选定的相关变量进行分组分析。此外,还将进行敏感性分析、偏倚风险评估、发表偏倚评估和质量评价:本系统综述将从 2023 年 11 月持续到 2024 年 6 月。没有发现相同的综述。最终确定了检索策略,开始进行书目检索,删除重复内容,并开始筛选标题和摘要。在检索到的 35 篇研究中,85 篇因重复而被排除,剩下 50 篇供选择:这项研究非常及时,与全国正在实施的伤害登记工作相吻合。通过综合现有证据,我们将确定伤害登记处在指导巴西决策者决策方面的潜力:PROSPERO CRD42023481528;https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=481528.International 注册报告标识符 (irrid):PRR1-10.2196/55029。
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引用次数: 0
Multidimensional School-Based and Family-Involved Interventions to Promote a Healthy and Sustainable Lifestyle (LIVELY) for Childhood Obesity Prevention: Study Protocol. 促进健康和可持续生活方式的多维校本和家庭参与干预(LIVELY),预防儿童肥胖症:研究协议。
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-10-30 DOI: 10.2196/57509
Sara Basilico, Maria Vittoria Conti, Ilaria Ardoino, Chiara Breda, Federica Loperfido, Elena Klaic, Linda Spialtini, Andreana Foresta, Francesca Orsini, Maria Luisa Ojeda Fernandez, Stefano Conca Bonizzoni, Elisabetta Modena, Yasamin Tootoonchi Hamedani, Federica Villa, Hellas Cena, Marta Baviera, Carlotta Franchi

Background: Childhood obesity has become a significant public health concern over the past 2 decades, posing multifactorial challenges, including modifiable factors like dietary habits, physical activity, screen time, and sleeping habits. Prevention efforts require a comprehensive approach comprising educational interventions, collaboration among multidisciplinary teams, and community engagement. Since schools play a central role in children's lives, they are the ideal setting for promoting healthy habits.

Objective: The LIVELY (Multidimensional School-Based and Family-Involved Interventions to Promote a Healthy and Sustainable Lifestyle) study will assess the prevalence of overweight and obesity in primary school children and identify contributing factors within families. Additionally, it aims to implement and evaluate a multidimensional, multidisciplinary intervention to foster a sustainable and healthy lifestyle, ultimately working toward preventing obesity in school-aged children.

Methods: During the school year, each class will be individually involved in a multidimensional educational intervention covering the topics of healthy, sustainable nutrition and lifestyle. Children will also participate in a multimedia lab where they will create an animated cartoon. The lectures will engage them through various methods, including direct instructions, games, and drawing activities, to stimulate and enhance their learning and involvement.

Results: Data collection began in October 2023 and will last until the end of October 2024. A sample of 227 children from 14 classes was included in the study. The mean age was 8.9 (SD 1.2) years, and 48% (n=110) were males. Among the overall sample, 18.1% (n=41; 95% CI 13.7%-23.7%) were overweight, while 5.3% (n=12; 95% CI 3%-9%) had obesity. Males had a higher prevalence of obesity than females (9.1%, n=10 vs 1.7%, n=3, P=.03, respectively). Otherwise, the prevalence of central obesity was similar between the two (P=.329). Data analysis and the presentation of the complete results will be available after the end of 2024.

Conclusions: The study could lead to the structuring of an educational intervention model in school settings aimed at preventing childhood obesity. Moreover, it could help raise awareness of childhood obesity and help prevent this public health issue.

Trial registration: ClinicalTrials.gov NCT05966051; https://clinicaltrials.gov/study/NCT05966051.

International registered report identifier (irrid): DERR1-10.2196/57509.

背景:过去 20 年来,儿童肥胖症已成为一个重大的公共卫生问题,它带来了多因素挑战,包括饮食习惯、体育活动、屏幕时间和睡眠习惯等可改变的因素。预防工作需要采取综合方法,包括教育干预、多学科团队合作和社区参与。由于学校在儿童生活中扮演着核心角色,因此是推广健康习惯的理想场所:LIVELY(促进健康和可持续生活方式的多维校本和家庭参与干预)研究将评估小学生超重和肥胖的发生率,并确定家庭中的诱因。此外,该研究还旨在实施和评估一种多维度、多学科的干预措施,以促进可持续的健康生活方式,最终达到预防学龄儿童肥胖的目的:方法:在本学年,每个班级都将单独参与一项多维教育干预活动,内容涉及健康、可持续的营养和生活方式。孩子们还将参加多媒体实验室,制作动画片。讲座将通过各种方法,包括直接指导、游戏和绘画活动,让他们参与其中,以激发和加强他们的学习和参与:数据收集工作于 2023 年 10 月开始,将持续到 2024 年 10 月底。本研究的样本包括来自 14 个班级的 227 名儿童。平均年龄为 8.9 岁(标准差为 1.2 岁),48%(n=110)为男性。在所有样本中,18.1%(n=41;95% CI 13.7%-23.7%)超重,5.3%(n=12;95% CI 3%-9%)肥胖。男性肥胖率高于女性(分别为 9.1%,n=10 对 1.7%,n=3,P=.03)。除此之外,两者的中心性肥胖发生率相似(P=.329)。数据分析和完整结果的提交将在 2024 年底之后进行:这项研究可以在学校环境中构建一种旨在预防儿童肥胖症的教育干预模式。此外,它还有助于提高人们对儿童肥胖症的认识,帮助预防这一公共卫生问题:试验注册:ClinicalTrials.gov NCT05966051;https://clinicaltrials.gov/study/NCT05966051.International 注册报告标识符 (irrid):DERR1-10.2196/57509。
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引用次数: 0
The Implementation of the Advocacy Intervention for Midlife and Older Women Who Have Experienced Intimate Partner Violence: Protocol for a Randomized Controlled Trial. 对遭受亲密伴侣暴力的中老年妇女实施宣传干预:随机对照试验方案》。
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-10-30 DOI: 10.2196/57886
Lori Weeks, Kathleen Allen, Catherine Holtmann, Joni Leger, Suzanne Dupuis-Blanchard, Colleen MacQuarrie, Marilyn Macdonald, Elaine Moody, Christie Stilwell, Heather Helpard, Danie Gagnon

Background: Midlife and older women who experience intimate partner violence (IPV) often have less access to supports and services than younger women. There is far less focus on research and supports for midlife and older women compared to younger women experiencing IPV, and often, neither elder abuse nor IPV services meet their needs. Few interventions are available to meet the needs of midlife and older women.

Objective: The goal of this randomized controlled trial is to test the effectiveness of an advocacy intervention for midlife and older women who experience IPV and to learn from the experiences of those who implement and participate in the program.

Methods: This trial is a 2-arm, unblinded, parallel, pragmatic randomized controlled trial with a qualitative component. Eligible participants will be women who live in the Maritime provinces of Canada (New Brunswick, Nova Scotia, and Prince Edward Island), who are in midlife and older (aged approximately ≥50 years), and who are currently in a relationship with an abusive partner or have recently left an abusive partner. Facilitators will be trained to deliver the intervention. The intervention will be entirely virtual and will consist of 2 components: (1) an empowerment component, which will involve sharing resources and information with the women; and (2) a social support component, which will include providing support and encouragement to women for 12 weeks. Quantitative effectiveness data will be collected from all trial participants at baseline, 3 months after the intervention, and 9 months after the intervention about the incidence and severity of IPV, physical and mental health, and safety behaviors and strategies. Qualitative interviews will be conducted with the facilitators and intervention group participants. Control group participants will receive a static, nontailored version of the advocacy intervention for midlife and older women (AIM) intervention materials after baseline data collection.

Results: A total of 12 facilitators have been trained to deliver the AIM intervention to trial participants. Participant recruitment and data collection will be completed in January 2025. Data analysis will continue throughout the data collection period, and the results will be disseminated by December 2025.

Conclusions: This research will result in the adaptation and testing of a program to support and empower midlife and older women in the Maritime provinces of Canada who experience IPV.

Trial registration: International Standard Randomized Controlled Trial Registry ISRCTN30646991; https://doi.org/10.1186/ISRCTN30646991.

International registered report identifier (irrid): DERR1-10.2196/57886.

背景:与年轻女性相比,遭受亲密伴侣暴力 (IPV) 的中年和老年女性获得的支持和服务往往较少。与遭受亲密伴侣暴力的年轻女性相比,针对中年和老年女性的研究和支持关注要少得多,而且虐待老人和亲密伴侣暴力服务往往都不能满足她们的需求。很少有干预措施可以满足中老年妇女的需求:本随机对照试验的目的是测试针对遭受 IPV 的中老年妇女的宣传干预措施的有效性,并从项目实施者和参与者的经验中汲取教训:本试验是一项双臂、非盲法、平行、务实的随机对照试验,其中包含定性部分。符合条件的参与者将是居住在加拿大滨海省(新不伦瑞克省、新斯科舍省和爱德华王子岛省)的中年及中年以上妇女(年龄约≥50 岁),目前正与施虐伴侣保持关系或最近刚离开施虐伴侣。主持人将接受培训,以进行干预。干预将完全采用虚拟方式,由两个部分组成:(1) 赋权部分,包括与妇女共享资源和信息;(2) 社会支持部分,包括在 12 周内为妇女提供支持和鼓励。将在基线、干预 3 个月后和干预 9 个月后收集所有试验参与者的定量有效性数据,内容涉及 IPV 的发生率和严重程度、身心健康以及安全行为和策略。将对主持人和干预组参与者进行定性访谈。对照组参与者将在基线数据收集后收到静态的、非定制版本的中老年妇女倡导干预(AIM)干预材料:共有 12 名辅导员接受了向试验参与者提供 AIM 干预方法的培训。参与者招募和数据收集工作将于 2025 年 1 月完成。数据分析将贯穿整个数据收集期,结果将于 2025 年 12 月公布:这项研究将调整和测试一项计划,为加拿大海洋省遭受 IPV 的中老年妇女提供支持和赋权:国际标准随机对照试验登记处 ISRCTN30646991;https://doi.org/10.1186/ISRCTN30646991.International 注册报告标识符 (irrid):DERR1-10.2196/57886。
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引用次数: 0
Differences in Messenger RNA Expression of Fibulin-1, Elastin, Matrix Metalloproteinase-1, Basic Fibroblast Growth Factor, and α-Smooth Muscle Actin Between the Ventral and Dorsal Tunica Dartos in Patients With Hypospadias and Chordee: Protocol for a Prospective Cohort Study. 尿道下裂和脊索畸形患者腹侧和背侧睾丸窦中纤维蛋白-1、弹性蛋白、基质金属蛋白酶-1、碱性成纤维细胞生长因子和α-平滑肌肌动蛋白的信使 RNA 表达差异:一项前瞻性队列研究的方案。
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-10-30 DOI: 10.2196/52282
Joko Pitoyo, Alvarino, Eryati Darwin, Yanwirasti

Background: Hypospadias is a common congenital anomaly characterized by the displacement of the urethral opening to the ventral side of the penis. Surgical correction is often necessary for functional and psychological reasons. The etiology involves genetic and environmental factors, and chordee, a downward curvature of the penis, is a common complication. Proteins such as fibulin-1, elastin, matrix metalloproteinase-1, basic fibroblast growth factor, and α-smooth muscle actin play roles in hypospadias development.

Objective: The study's aim is to investigate the differences in messenger RNA (mRNA) expression of fibulin-1, elastin, matrix metalloproteinase-1, basic fibroblast growth factor, and α-smooth muscle actin between the ventral and dorsal tunica dartos in patients with hypospadias and chordee.

Methods: This prospective cohort study aims to investigate differences in mRNA expression of the abovementioned proteins between the ventral and dorsal tunica dartos in patients with hypospadias and chordee. Ethics approval has been obtained, and consent from parents will be obtained before data collection. Eligible participants are aged 6-18 months, diagnosed with hypospadias and chordee, and planned for urethroplasty. Tissue samples will be collected from both aspects of the tunica dartos and analyzed using real-time quantitative reverse transcription-polymerase chain reaction. Data analysis will involve statistical tests and normalization of housekeeping genes.

Results: This study is at the protocol development stage. A pilot study regarding its feasibility has been ongoing as of August 2023. The study results are expected to be available by the end of 2024.

Conclusions: The study of mRNA expressions of various proteins in the tunica dartos of patients with hypospadias and chordee is expected to improve the understanding and expand the knowledge of the pathophysiology of hypospadias and chordee.

International registered report identifier (irrid): DERR1-10.2196/52282.

背景:尿道下裂是一种常见的先天性畸形,其特征是尿道口移位至阴茎腹侧。由于功能和心理原因,通常需要进行手术矫正。病因涉及遗传和环境因素,阴茎向下弯曲(chordee)是常见的并发症。纤维蛋白-1、弹性蛋白、基质金属蛋白酶-1、碱性成纤维细胞生长因子和α-平滑肌肌动蛋白等蛋白质在尿道下裂的发育过程中发挥作用:该研究旨在探讨尿道下裂和脊索畸形患者腹侧和背侧睾丸外膜之间纤维蛋白-1、弹性蛋白、基质金属蛋白酶-1、碱性成纤维细胞生长因子和α-平滑肌肌动蛋白的信使RNA(mRNA)表达差异:这项前瞻性队列研究旨在调查尿道下裂和脊索畸形患者腹侧和背侧睾丸韧带中上述蛋白质 mRNA 表达的差异。该研究已获得伦理批准,并将在收集数据前征得家长同意。符合条件的参与者年龄为 6-18 个月,被诊断为尿道下裂和脊索畸形,并计划进行尿道成形术。将从尿道两侧收集组织样本,并使用实时定量反转录聚合酶链反应进行分析。数据分析将包括统计检验和标准化看家基因:这项研究正处于方案制定阶段。截至 2023 年 8 月,有关其可行性的试点研究一直在进行中。研究结果预计将于 2024 年底公布:尿道下裂和脊索畸形患者尿道内膜中各种蛋白质 mRNA 表达的研究有望加深对尿道下裂和脊索畸形病理生理学的理解并拓展相关知识:DERR1-10.2196/52282。
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