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Mental Health Monitoring for Young People Through Mood Apps: Protocol for a Scoping Review and Systematic Search in App Stores. 通过情绪应用程序监测青少年心理健康:在应用程序商店进行范围审查和系统搜索的协议》。
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-19 DOI: 10.2196/56400
Selina Boege, Madison Milne-Ives, Ananya Ananthakrishnan, Cen Cong, Aditya Sharma, David Anderson, Edward Meinert

Background: The researchers have used mobile phones to assist in monitoring, analyzing, and managing moods to acquire insight into mood patterns. There is a lack of evidence in their use as clinical tools and interventions, which necessitates a comprehensive review and quality assessment to understand barriers and facilitators for app implementation as an impactful clinical intervention.

Objective: This review aims to (1) provide an overview of the recent evidence on mobile mood-monitoring apps that are intended for facilitating self-management and support of mental health in children, adolescents, and young people; and (2) investigate the quality of publicly available apps.

Methods: The study will first involve a scoping review of the literature on mood-monitoring apps for children, adolescents, and young people followed by an evaluation of features of the apps available in the marketplace. The scoping review will follow the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines and search 6 databases- Embase, CINAHL, PubMed, ACM Digital Library, Scopus, and Springer LNCS-for relevant studies and reviews published in the last 3 years. The author will then screen the references, extract data from the included studies, and analyze them to synthesize the evidence on mood apps. Next, the Apple App Store and Google Play Store will be searched for mood apps. A total of 2 independent reviewers will screen the apps based on eligibility criteria, and disagreements will be resolved through consensus. The features of the selected apps will then be evaluated using the Mobile Health Index and Navigation framework, and descriptive analysis will be used to synthesize the findings.

Results: Literature search and screening began soon after submission of the protocol and is expected to be completed by September 2024. The app evaluation will be completed by October 2024.

Conclusions: Combined, the scoping literature review and app evaluation will provide an in-depth overview of the most recent scientific evidence related to mood apps and the quality of apps actually available for use.

International registered report identifier (irrid): PRR1-10.2196/56400.

研究背景研究人员利用手机协助监测、分析和管理情绪,以深入了解情绪模式。目前还缺乏将其用作临床工具和干预措施的证据,因此有必要进行一次全面的综述和质量评估,以了解将应用程序用作有影响力的临床干预措施的障碍和促进因素:本综述旨在:(1)概述旨在促进儿童、青少年自我管理和支持心理健康的手机情绪监测应用程序的最新证据;(2)调查公开可用应用程序的质量:研究将首先对有关儿童、青少年和年轻人情绪监控应用程序的文献进行范围界定,然后对市场上现有应用程序的功能进行评估。范围综述将遵循 PRISMA-ScR(系统性综述和元分析的首选报告项目,范围综述的扩展)指南,搜索 6 个数据库--Embase、CINAHL、PubMed、ACM 数字图书馆、Scopus 和 Springer LNCS--过去 3 年中发表的相关研究和综述。然后,作者将对参考文献进行筛选,从收录的研究中提取数据并进行分析,以综合有关情绪应用程序的证据。接下来,作者将在苹果应用商店和谷歌应用商店搜索情绪应用程序。共有两名独立评审员将根据资格标准对应用程序进行筛选,并通过协商一致的方式解决分歧。然后,将使用移动健康指数和导航框架对所选应用程序的功能进行评估,并使用描述性分析对结果进行综合:文献检索和筛选工作在提交协议后很快就开始了,预计将于 2024 年 9 月完成。应用程序评估将于 2024 年 10 月完成:结合范围界定文献综述和应用程序评估,将深入概述与情绪应用程序相关的最新科学证据以及实际可用应用程序的质量:PRR1-10.2196/56400。
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引用次数: 0
Exploring the Experiences of Times Without Care and Encounters in Persons With Dementia in the Swiss and German Nursing Home and Domiciliary Care Settings: Protocol for an Ethnographic Multimethods Study. 探索瑞士和德国养老院及家庭护理环境中痴呆症患者在无护理和邂逅时的经历:人种学多方法研究协议》。
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-18 DOI: 10.2196/58190
Thomas Beer, Julian Hirt, Laura Adlbrecht, Ulrike Lindwedel, Matthias Dammert, Carola Maurer, Matthias Kliegel, Peter König, Helma M Bleses
<p><strong>Background: </strong>Persons with dementia spend a large part of the day without care and encounters, often without activity, as confirmed by numerous studies. However, no scientific analysis has examined how persons with dementia experience these periods. Such knowledge would be highly relevant for health care professionals and relatives to develop adequate strategies for dealing with times without care.</p><p><strong>Objective: </strong>We aim to reconstruct times without care and encounters in persons with dementia in the nursing home and domiciliary care settings and develop a typology. This typology will address the lifeworld understandings of time and the ways of arranging the time of persons with dementia.</p><p><strong>Methods: </strong>Our study is designed as an explorative, sequential multimethods investigation. We aim to systematically reconstruct times without care and encounters over a period of 36 months using ethnographic methods. Afterward, we will examine the resulting typology using a survey. To describe different social and caring cultures, practices, and arrangements, we will analyze time periods across all phases of dementia in (1) institutions exclusively caring for persons with dementia, (2) institutions where persons with dementia and those without live together, and (3) domiciliary care. For each type of care, our target is 10 intensive case observations. These observations will occur in both participatory and nonparticipatory ways. We video record selected situations and conduct situational conversations and interviews with persons with dementia and nurses. We are aiming for a minimum sample of 30 persons with dementia plus their caregivers (ie, relatives of people with dementia and professional caregivers). We will analyze data according to grounded theory methodology. Furthermore, we will perform a hermeneutic sequence analysis of selected text passages. To interpret the video material, we will conduct a video interaction analysis. To obtain complementary information about the newly developed typology, we will survey approximately 400 formal and 150 informal caregivers. We will summarize the ethnography and survey findings into an overall concept of times without care and encounters in persons with dementia. To fulfill the research objectives, our cross-disciplinary and cross-country team comprises researchers with expertise in nursing sciences, gerontology, sociology, psychology, and ethnography.</p><p><strong>Results: </strong>Our approach allows formulating statements about the nature, frequency, and prevalence of times without care and encounters in people with dementia across countries and types of care. Thus, we will contribute to making visible the lifeworld of persons with dementia. Our study commenced in March 2022 and will conclude in May 2025. The results are expected to be published in the fall of 2025.</p><p><strong>Conclusions: </strong>Our research offers points of departure for the represent
背景:大量研究证实,痴呆症患者一天中有很大一部分时间没有人照顾和陪伴,通常也没有活动。然而,还没有科学分析研究过痴呆症患者是如何经历这些时间段的。这些知识对于医护人员和患者亲属制定适当的策略以应对无照料时间具有重要意义:我们的目标是重建养老院和家庭护理环境中痴呆症患者的无护理时间和遭遇,并建立一个类型学。这种类型学将涉及痴呆症患者生活世界中对时间的理解以及安排时间的方式:我们的研究是一项探索性、连续性的多方法调查。我们的目标是采用人种学方法,系统地重建 36 个月内没有护理和接触的时间。之后,我们将通过调查研究由此产生的类型学。为了描述不同的社会和照护文化、实践和安排,我们将分析痴呆症各个阶段的时间段,包括(1)专门照护痴呆症患者的机构,(2)痴呆症患者和非痴呆症患者共同生活的机构,以及(3)家庭照护。对于每种类型的护理,我们的目标是进行 10 次深入的个案观察。这些观察将以参与式和非参与式两种方式进行。我们会对选定的情况进行录像,并与痴呆症患者和护士进行情景对话和访谈。我们的目标是至少抽取 30 名痴呆症患者及其护理人员(即痴呆症患者的亲属和专业护理人员)。我们将根据基础理论方法对数据进行分析。此外,我们还将对选定的文本段落进行诠释序列分析。为了解读视频资料,我们将进行视频互动分析。为了获得有关新开发的类型学的补充信息,我们将对大约 400 名正式护理人员和 150 名非正式护理人员进行调查。我们将对人种学研究和调查结果进行总结,形成一个关于痴呆症患者无照顾和无接触时间的整体概念。为了实现研究目标,我们的跨学科和跨国团队由具备护理科学、老年学、社会学、心理学和人种学专业知识的研究人员组成:通过我们的研究方法,可以对不同国家和不同护理类型的痴呆症患者缺乏护理和遭遇的时间的性质、频率和普遍性做出说明。因此,我们将为展现痴呆症患者的生活世界做出贡献。我们的研究于 2022 年 3 月开始,将于 2025 年 5 月结束。研究结果预计将于 2025 年秋季发表:我们的研究为有代表性地调查痴呆症患者没有护理和遭遇的时间、开发诊断工具以及批判性地处理中断的可能性(例如,通过开发有针对性的干预措施)提供了出发点:DERR1-10.2196/58190。
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引用次数: 0
Factors Influencing Outcome After Shoulder Arthroplasty (FINOSA Study): Protocol of a Prospective Longitudinal Study With Randomized Group Allocation. 影响肩关节置换术后效果的因素(FINOSA 研究):随机分组的前瞻性纵向研究方案。
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-18 DOI: 10.2196/56522
Anke Claes, Annelien De Mesel, Thomas Struyf, Olivier Verborgt, Filip Struyf

Background: There is an increasing need for evidence-based postoperative rehabilitation strategies to optimize patient outcome. Knowledge of potential prognostic factors could steer the development of rehabilitation protocols and could result in better treatment outcomes and higher patient satisfaction.

Objective: This study aimed to investigate which potential prognostic factors predict baseline shoulder pain and function and its evolution in the first 2 years following surgery, in patients with total shoulder arthroplasty. The secondary objective is to investigate which potential prognostic factors predict baseline quality of life and its evolution in the first two years following surgery.

Methods: To reach the aims of this project, a prospective longitudinal study, running from January 2020 to March 2025, will be carried out with a follow-up of 48 months. Patients will be randomized based on sling wear. We will study factors such as shoulder function, patient expectations, psychosocial factors, lifestyle factors, sling wear, soft tissue integrity, and physiotherapy treatment. Test moments will take place preoperatively, at 6 weeks, 12 weeks, 6 months, 12 months, and 24 months. Descriptive statistics will be used to describe the patient population characteristics. Based on literature review, expert opinion, and univariate analyses, potential prognostic factors will be chosen as covariates. A mixed regression model for repeated measures will be used to assess both the evolution of the Shoulder Pain and Disability Index within persons from baseline over time and the differences in evolution between participants. Correlation analyses will be used to investigate associations between the other outcome measures such as the Constant and Murley Score, shoulder range of motion, shoulder muscle strength, and proprioception, and the primary outcome measure, the Shoulder Pain and Disability Index score. Potential prognostic factors not included in the model will be presented in a descriptive manner.

Results: Data collection started in January 2020. In April 2023 the sample size was reached. Data collection will end in April 2025. Analyses will follow when data collection is completed.

Conclusions: Knowledge of potential prognostic factors will have implications toward better rehabilitation strategies of patients after total shoulder arthroplasty.

Trial registration: ClinicalTrials.gov NCT04258267; https://clinicaltrials.gov/study/NCT04258267.

International registered report identifier (irrid): DERR1-10.2196/56522.

背景:现在越来越需要以证据为基础的术后康复策略来优化患者的预后。对潜在预后因素的了解可指导康复方案的制定,并可获得更好的治疗效果和更高的患者满意度:本研究旨在调查哪些潜在预后因素可预测全肩关节置换术患者的肩部疼痛和功能基线及其术后头两年的变化。次要目标是研究哪些潜在预后因素可预测基线生活质量及其在术后头两年的变化:为实现本项目的目标,将在 2020 年 1 月至 2025 年 3 月期间开展一项为期 48 个月的前瞻性纵向研究。患者将根据穿戴吊衣的情况进行随机分组。我们将研究肩关节功能、患者期望、社会心理因素、生活方式因素、吊衣磨损、软组织完整性和理疗治疗等因素。测试时刻将在术前、6 周、12 周、6 个月、12 个月和 24 个月时进行。将使用描述性统计来描述患者群体的特征。根据文献综述、专家意见和单变量分析,选择潜在的预后因素作为协变量。将使用重复测量的混合回归模型来评估肩痛和肩周炎指数从基线开始随时间推移的变化情况,以及参与者之间的变化差异。相关性分析将用于研究其他结果测量(如康斯坦茨和默里评分、肩部活动范围、肩部肌肉力量和本体感觉)与主要结果测量(肩痛和残疾指数评分)之间的关联。未纳入模型的潜在预后因素将以描述性方式呈现:数据收集始于 2020 年 1 月。2023 年 4 月达到样本量。数据收集工作将于 2025 年 4 月结束。数据收集完成后将进行分析:了解潜在的预后因素将有助于改善全肩关节置换术后患者的康复策略:试验注册:ClinicalTrials.gov NCT04258267;https://clinicaltrials.gov/study/NCT04258267.International 注册报告标识符 (irrid):DERR1-10.2196/56522。
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引用次数: 0
Factors Influencing Domestic Human Trafficking in Africa: Protocol for a Scoping Review. 影响非洲国内人口贩运的因素:范围界定审查议定书》。
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-18 DOI: 10.2196/56392
Loubna Belaid, Ivan Sarmiento, Anna Dion, Andrés Rojas Cardenas, Anne Cockcroft, Neil Andersson

Background: Human trafficking is a human rights violation in every region of the world. The African continent is not spared. Every year, millions of people experience significant health and social consequences. International organizations and governments combating human trafficking are hindered by a lack of knowledge about what factors influence domestic (within-country) human trafficking.

Objective: This study aims to conduct a scoping review to collate and synthesize literature on factors influencing domestic trafficking in Africa.

Methods: We will follow Arksey and O'Malley's framework to answer the question about reported influences on domestic human trafficking and their relative weight. The search strategy will explore PubMed, CINAHL, Web of Science, and Scopus. A total of 2 independent researchers will select quantitative, qualitative, or mixed methods studies that examine relationships influencing domestic human trafficking. We will document our results by following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines. We will extract a list of all reported relationships between identified factors influencing domestic human trafficking in each study. Based on a discourse analysis approach, we will weigh the strengths of the relationships based on how frequently they are reported across the included studies. We will summarize the findings as fuzzy cognitive maps depicting the relationships reported in the literature. The maps represent the influences between concepts (nodes) linked by arrows (edges) going from each cause to its outcomes. These maps are helpful visual summaries of the factors associated with domestic human trafficking, allowing a comparison with maps to be created by stakeholder groups.

Results: This project received financial support in March 2023. We expect to start the project in March 2024. We recruited 2 research staff members to conduct the scoping review and expect to publish the results in March 2025.

Conclusions: The review will provide a comprehensive understanding of factors influencing domestic human trafficking in Africa. The overlap of human trafficking with other forms of exploitation, the limited literature on domestic human trafficking, and the likely diversity of factors are challenges for the review. We propose strategies to address these challenges.

International registered report identifier (irrid): PRR1-10.2196/56392.

背景:人口贩运是世界各个地区侵犯人权的行为。非洲大陆也未能幸免。每年都有数百万人遭受严重的健康和社会后果。由于缺乏对影响国内(国内)人口贩运的因素的了解,国际组织和各国政府打击人口贩运的行动受到了阻碍:本研究旨在进行范围界定审查,整理和归纳有关影响非洲国内人口贩运因素的文献:我们将遵循 Arksey 和 O'Malley 的框架,回答有关国内人口贩运影响因素及其相对权重的问题。搜索策略将包括 PubMed、CINAHL、Web of Science 和 Scopus。共有 2 名独立研究人员将选择定量、定性或混合方法研究,探讨影响国内人口贩运的各种关系。我们将按照 PRISMA-ScR(系统性综述和 Meta 分析的首选报告项目,范围综述的扩展)指南记录研究结果。我们将提取每项研究中所有已确定的影响国内人口贩运因素之间关系的报告列表。根据话语分析方法,我们将根据纳入研究中报告的频率来权衡这些关系的强度。我们将把研究结果总结为模糊认知地图,描述文献中报告的关系。这些地图表示概念(节点)之间的影响,并由从每个原因到结果的箭头(边)连接起来。这些地图有助于直观地总结与国内人口贩运相关的因素,并可与利益相关群体绘制的地图进行比较:该项目于 2023 年 3 月获得资金支持。我们预计在 2024 年 3 月启动该项目。我们招聘了 2 名研究人员进行范围界定审查,预计将于 2025 年 3 月公布审查结果:此次审查将全面了解影响非洲国内人口贩运的因素。人口贩运与其他剥削形式的重叠、有关国内人口贩运的文献有限以及各种因素的可能多样性是审查面临的挑战。我们提出了应对这些挑战的策略:PRR1-10.2196/56392。
{"title":"Factors Influencing Domestic Human Trafficking in Africa: Protocol for a Scoping Review.","authors":"Loubna Belaid, Ivan Sarmiento, Anna Dion, Andrés Rojas Cardenas, Anne Cockcroft, Neil Andersson","doi":"10.2196/56392","DOIUrl":"10.2196/56392","url":null,"abstract":"<p><strong>Background: </strong>Human trafficking is a human rights violation in every region of the world. The African continent is not spared. Every year, millions of people experience significant health and social consequences. International organizations and governments combating human trafficking are hindered by a lack of knowledge about what factors influence domestic (within-country) human trafficking.</p><p><strong>Objective: </strong>This study aims to conduct a scoping review to collate and synthesize literature on factors influencing domestic trafficking in Africa.</p><p><strong>Methods: </strong>We will follow Arksey and O'Malley's framework to answer the question about reported influences on domestic human trafficking and their relative weight. The search strategy will explore PubMed, CINAHL, Web of Science, and Scopus. A total of 2 independent researchers will select quantitative, qualitative, or mixed methods studies that examine relationships influencing domestic human trafficking. We will document our results by following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines. We will extract a list of all reported relationships between identified factors influencing domestic human trafficking in each study. Based on a discourse analysis approach, we will weigh the strengths of the relationships based on how frequently they are reported across the included studies. We will summarize the findings as fuzzy cognitive maps depicting the relationships reported in the literature. The maps represent the influences between concepts (nodes) linked by arrows (edges) going from each cause to its outcomes. These maps are helpful visual summaries of the factors associated with domestic human trafficking, allowing a comparison with maps to be created by stakeholder groups.</p><p><strong>Results: </strong>This project received financial support in March 2023. We expect to start the project in March 2024. We recruited 2 research staff members to conduct the scoping review and expect to publish the results in March 2025.</p><p><strong>Conclusions: </strong>The review will provide a comprehensive understanding of factors influencing domestic human trafficking in Africa. The overlap of human trafficking with other forms of exploitation, the limited literature on domestic human trafficking, and the likely diversity of factors are challenges for the review. We propose strategies to address these challenges.</p><p><strong>International registered report identifier (irrid): </strong>PRR1-10.2196/56392.</p>","PeriodicalId":14755,"journal":{"name":"JMIR Research Protocols","volume":"13 ","pages":"e56392"},"PeriodicalIF":1.4,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Video-Based Communication Intervention for Fecal Ostomy Surgery (CI-oSurg): Protocol for Open Pilot Testing to Improve Intervention Acceptability and Feasibility. 基于视频的粪便造口手术沟通干预(CI-oSurg):公开试点测试协议,提高干预的可接受性和可行性。
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-15 DOI: 10.2196/60575
Christy Elaine Cauley, Atziri Rubio, Mary Brindle, Zara Cooper, Ana-Maria Vranceanu, Christine S Ritchie

Background: Approximately 100,000 patients undergo fecal ostomy operations annually across the United States. This patient population experiences high surgical complication rates and poor biopsychosocial outcomes. Surgical teams are not trained to address the psychosocial needs that often arise during recovery after fecal ostomy surgery.

Objective: This study aims to refine and establish the acceptability and usability of the Communication Intervention for fecal ostomy Surgery (CI-oSurg), a web-based communication intervention aimed at reducing distress among patients recovering from ostomy surgery.

Methods: We describe the proposed study design, methodology, and training protocol. We will conduct an open pilot (n=24 patients and n=8 clinicians) of video-based training to first identify the level and types of distress patients are experiencing. Next, patients will view web videos that address frequent challenges faced by ostomy patients, considering practical management and emotional and adaptation concerns. Qualitative one-to-one semistructured interviews will be conducted with participants to explore the acceptability and feasibility of the program and refine the intervention and study procedures.

Results: This study has been approved by the Mass General Brigham Institutional Review Board. Study funding has been obtained, and recruitment is planned for the fall of 2024.

Conclusions: Through this study, we will refine CI-oSurg, a web-based communication intervention focused on reducing distress after ostomy surgery, to improve intervention acceptability and usability. These improvements will allow us to establish the usability and acceptability of the intervention before efficacy testing to determine the ability of this intervention to reduce distress after fecal ostomy surgery.

Trial registration: ClinicalTrials.gov NCT06320002; https://clinicaltrials.gov/study/NCT06320002.

International registered report identifier (irrid): PRR1-10.2196/60575.

背景:美国每年约有 10 万名患者接受造瘘手术。这类患者的手术并发症发生率高,生物心理社会效果差。手术团队没有接受过培训,无法满足粪便造口手术后恢复期间经常出现的社会心理需求:本研究旨在完善和确定粪便造口手术沟通干预(CI-oSurg)的可接受性和可用性,这是一种基于网络的沟通干预,旨在减少造口手术后恢复期患者的痛苦:我们将介绍拟议的研究设计、方法和培训方案。我们将对基于视频的培训进行公开试点(24 名患者和 8 名临床医生),首先确定患者所经历的痛苦程度和类型。接下来,患者将观看针对造口患者经常面临的挑战的网络视频,考虑实际管理、情感和适应问题。将对参与者进行一对一半结构化定性访谈,以探讨该计划的可接受性和可行性,并完善干预措施和研究程序:本研究已获得 Mass General Brigham 机构审查委员会的批准。研究经费已经到位,计划于 2024 年秋季进行招募:通过这项研究,我们将改进 CI-oSurg(一种基于网络的交流干预措施,主要用于减轻造口手术后的痛苦),以提高干预措施的可接受性和可用性。这些改进将使我们能够在疗效测试前确定干预措施的可用性和可接受性,以确定该干预措施能否减轻造口手术后的痛苦:ClinicalTrials.gov NCT06320002; https://clinicaltrials.gov/study/NCT06320002.International 注册报告标识符 (irrid):PRR1-10.2196/60575。
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引用次数: 0
Progress of Implementation of World Health Organization Global Antimicrobial Resistance Surveillance System Recommendations on Priority Pathogen-Antibiotic Sensitivity Testing in Africa: Protocol for a Scoping Review. 世界卫生组织全球抗菌药物耐药性监测系统关于非洲优先病原体-抗生素敏感性检测建议的实施进展:范围审查协议》。
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-15 DOI: 10.2196/58140
Mackline Hope, Reuben Kiggundu, Dathan M Byonanebye, Jonathan Mayito, Dickson Tabajjwa, Fahad Lwigale, Conrad Tumwine, Herman Mwanja, Andrew Kambugu, Francis Kakooza

Background: Antimicrobial resistance (AMR) is a major global public health concern, particularly in low- and middle-income countries where resources and infrastructure for an adequate response are limited. The World Health Organization (WHO) Global Antimicrobial Resistance Surveillance System (GLASS) was introduced in 2016 to address these challenges, outlining recommendations for priority pathogen-antibiotic combinations. Despite this initiative, implementation in Africa remains understudied. This scoping review aims to assess the current state of implementing WHO GLASS recommendations on antimicrobial sensitivity testing (AST) in Africa.

Objective: The primary objective of this study is to determine the current state of implementing the WHO GLASS recommendations on AST for priority pathogen-antimicrobial combinations. The review will further document if the reporting of AST results is according to "susceptible," "intermediate," and "resistant" recommendations according to GLASS.

Methods: Following the methodological framework by Arksey and O'Malley, studies published between January 2016 and November 2023 will be included. Search strategies will target electronic databases, including MEDLINE, Scopus, CINAHL, and Embase. Eligible studies will document isolates tested for antimicrobial sensitivity, focusing on WHO-priority specimens and pathogens. Data extraction will focus on key study characteristics, study context, population, and adherence to WHO GLASS recommendations on AST. Descriptive statistics involving summarizing the quantitative data extracted through measures of central tendency and variation will be used. Covidence and Microsoft Excel software will be used. This study will systematically identify, collate, and analyze relevant studies and data sources based on clear inclusion criteria to provide a clear picture of the progress achieved in the implementation of the WHO GLASS recommendations. Areas for further improvement will be documented to inform future efforts to strengthen GLASS implementation for enhanced AMR surveillance in Africa.

Results: The study results are expected in August 2024.

Conclusions: To our knowledge, this scoping review will be the first to comprehensively examine the implementation of WHO GLASS recommendations in Africa, shedding light on the challenges and successes of AMR surveillance in the region. Addressing these issues aims to contribute to global efforts to combat AMR.

International registered report identifier (irrid): PRR1-10.2196/58140.

背景:抗菌药耐药性(AMR)是全球公共卫生领域的一个重大问题,尤其是在中低收入国家,因为这些国家用于充分应对的资源和基础设施有限。为应对这些挑战,世界卫生组织(WHO)于2016年推出了全球抗菌药物耐药性监测系统(GLASS),概述了病原体-抗生素优先组合的建议。尽管采取了这一举措,但在非洲的实施情况仍未得到充分研究。本范围界定综述旨在评估非洲实施世界卫生组织抗菌药物敏感性检测(AST)GLASS建议的现状:本研究的主要目的是确定重点病原体-抗菌药物组合抗菌药物敏感性检测(AST)的世卫组织全球监测系统(GLASS)建议的实施现状。审查将进一步记录 AST 结果的报告是否符合 GLASS 提出的 "易感"、"中等 "和 "耐药 "建议:按照 Arksey 和 O'Malley 的方法框架,将纳入 2016 年 1 月至 2023 年 11 月间发表的研究。检索策略将以电子数据库为目标,包括 MEDLINE、Scopus、CINAHL 和 Embase。符合条件的研究将记录抗菌药敏感性检测分离物,重点关注 WHO 优先标本和病原体。数据提取将重点关注关键研究特征、研究背景、研究人群以及是否符合 WHO GLASS 关于 AST 的建议。将使用描述性统计方法,通过中心倾向和变异度量对提取的定量数据进行总结。将使用 Covidence 和 Microsoft Excel 软件。本研究将根据明确的纳入标准,系统地识别、整理和分析相关研究和数据源,以便清楚地了解在实施世界卫生组织 GLASS 建议方面所取得的进展。还将记录有待进一步改进的领域,为今后加强全球监测系统的实施工作提供信息,以增强非洲的 AMR 监测能力:研究结果预计将于 2024 年 8 月公布:据我们所知,此次范围界定审查将是首次全面审查世卫组织全球监测系统建议在非洲的实施情况,揭示该地区 AMR 监测所面临的挑战和取得的成功。解决这些问题的目的是为全球抗击 AMR 的努力做出贡献:PRR1-10.2196/58140。
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引用次数: 0
Methodology for Biological Sample Collection, Processing, and Storage in the Newcastle 1000 Pregnancy Cohort: Protocol for a Longitudinal, Prospective Population-Based Study in Australia. 纽卡斯尔 1000 人妊娠队列中生物样本的采集、处理和储存方法:澳大利亚纵向、前瞻性人口研究协议。
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-15 DOI: 10.2196/63562
Joshua J Fisher, Tegan Grace, Nathan A Castles, Elizabeth A Jones, Sarah J Delforce, Alexandra E Peters, Gabrielle K Crombie, Emily C Hoedt, Kirby E Warren, Richard Gs Kahl, Jonathan J Hirst, Kirsty G Pringle, Craig E Pennell

Background: Research in the developmental origins of health and disease provides compelling evidence that adverse events during the first 1000 days of life from conception can impact life course health. Despite many decades of research, we still lack a complete understanding of the mechanisms underlying some of these associations. The Newcastle 1000 Study (NEW1000) is a comprehensive, prospective population-based pregnancy cohort study based in Newcastle, New South Wales, Australia, that will recruit pregnant women and their partners at 11-14 weeks' gestation, with assessments at 20, 28, and 36 weeks; birth; 6 weeks; and 6 months, in order to provide detailed data about the first 1000 days of life to investigate the developmental origins of noncommunicable diseases.

Objective: The study aims to provide a longitudinal multisystem approach to phenotyping, supported by robust clinical data and collection of biological samples in NEW1000.

Methods: This manuscript describes in detail the large variety of samples collected in the study and the method of collection, storage, and utility of the samples in the biobank, with a particular focus on incorporation of the samples into emerging and novel large-scale "-omics" platforms, including the genome, microbiome, epigenome, transcriptome, fragmentome, metabolome, proteome, exposome, and cell-free DNA and RNA. Specifically, this manuscript details the methods used to collect, process, and store biological samples, including maternal, paternal, and fetal blood, microbiome (stool, skin, vaginal, oral), urine, saliva, hair, toenail, placenta, colostrum, and breastmilk.

Results: Recruitment for the study began in March 2021. As of July 2024, 1040 women and 684 partners were enrolled, with 922 infants born. The NEW1000 biobank contains 24,357 plasma aliquots from ethylenediaminetetraacetic acid (EDTA) tubes, 5284 buffy coat aliquots, 4000 plasma aliquots from lithium heparin tubes, 15,884 blood serum aliquots, 2977 PAX RNA tubes, 26,595 urine sample aliquots, 2280 fecal swabs, 17,687 microbiome swabs, 2356 saliva sample aliquots, 1195 breastmilk sample aliquots, 4007 placental tissue aliquots, 2680 hair samples, and 2193 nail samples.

Conclusions: NEW1000 will generate a multigenerational, deeply phenotyped cohort with a comprehensive biobank of samples relevant to a large variety of analyses, including multiple -omics platforms.

International registered report identifier (irrid): DERR1-10.2196/63562.

背景:对健康和疾病发展起源的研究提供了令人信服的证据,表明从受孕开始的生命最初 1000 天内发生的不良事件会影响人一生的健康。尽管经过数十年的研究,我们仍然对其中一些关联的机制缺乏全面的了解。纽卡斯尔1000研究(Newcastle 1000 Study,NEW1000)是一项以澳大利亚新南威尔士州纽卡斯尔市为基地的综合性前瞻性人群妊娠队列研究,该研究将在孕妇妊娠11-14周时招募孕妇及其伴侣,并在妊娠20、28和36周、出生、6周和6个月时进行评估,以提供生命最初1000天的详细数据,从而研究非传染性疾病的发育起源:该研究旨在提供一种纵向多系统表型分析方法,并辅以可靠的临床数据和新生儿1000天生物样本的采集:本手稿详细描述了该研究中收集的大量样本,以及样本在生物库中的收集、储存和使用方法,尤其侧重于将样本纳入新兴和新型的大规模 "组学 "平台,包括基因组、微生物组、表观基因组、转录组、片段组、代谢组、蛋白质组、暴露组以及无细胞 DNA 和 RNA。具体来说,本手稿详细介绍了收集、处理和储存生物样本的方法,包括母体、父胎和胎儿的血液、微生物组(粪便、皮肤、阴道、口腔)、尿液、唾液、头发、脚趾甲、胎盘、初乳和母乳:研究于 2021 年 3 月开始招募。截至 2024 年 7 月,共有 1040 名妇女和 684 名伴侣参加了研究,其中有 922 名婴儿出生。NEW1000 生物库包含 24357 份来自乙二胺四乙酸(EDTA)试管的血浆等分试样、5284 份水溶液等分试样、4000 份来自肝素锂试管的血浆等分试样、15884 份血清等分试样、2977 份 PAX RNA 试管、26,595 份尿液样本等分试样、2280 份粪便拭子、17,687 份微生物组拭子、2356 份唾液样本等分试样、1195 份母乳样本等分试样、4007 份胎盘组织样本等分试样、2680 份头发样本和 2193 份指甲样本。结论NEW1000将产生一个多代、深度表型的队列,其全面的生物样本库与多种分析(包括多种组学平台)相关:DERR1-10.2196/63562。
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引用次数: 0
Barriers and Facilitators Affecting Access to Health Care for People With Syphilis: Protocol for a Scoping Review. 影响梅毒患者获得医疗服务的障碍和促进因素:范围界定审查协议》。
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-15 DOI: 10.2196/63561
Rafaela Bezerra Façanha Correia, Rafaela Prudlik Mourad, Janmilli da Costa Dantas, Richardson Augusto Rosendo da Silva

Background: Syphilis is a systemic, preventable, and curable infection caused by the bacterium Treponema pallidum. Despite being treatable, syphilis continues to have a high incidence, with a resurgence observed even in countries with strong health surveillance systems. This highlights the need to understand the various strategies used globally to improve access to care for individuals with syphilis.

Objective: This scoping review aims to identify and map the barriers and facilitators affecting access to health care for people with syphilis.

Methods: This scoping review will follow the methodology outlined by the Joanna Briggs Institute. The search will be conducted across several databases, including PubMed/MEDLINE, Scopus, Embase, LILACS (Virtual Health Library), and CINAHL (EBSCO). In addition, sources of unpublished studies or gray literature will be explored. Studies focusing on access to health care for individuals with syphilis will be included, regardless of geographic location, country, or language. Two independent reviewers will assess the results, and data will be extracted using a tool specifically developed for this review. The extracted quantitative data will be presented in tables and analyzed using descending hierarchical classification, represented by a class dendrogram. Barriers and facilitators will be categorized into dimensions of access.

Results: Database searching began in October 2024. Full-text screening and review are expected to be completed in December 2024. Data extraction and analysis are expected to be completed by February 2025, and the final report will be completed in March 2025.

Conclusions: The findings of this scoping review, guided by this protocol, will elucidate the main barriers and facilitators that affect access to syphilis treatment. This study may contribute to the practices of health professionals, managers, and the academic community, and provide relevant information for the population.

Trial registration: Open Science Framework Registries osf.io/kpsab; https://osf.io/kpsab.

International registered report identifier (irrid): PRR1-10.2196/63561.

背景:梅毒是由苍白螺旋体引起的一种可预防、可治愈的全身性感染。尽管梅毒是可以治疗的,但其发病率仍然很高,即使是在拥有强大卫生监督系统的国家,梅毒的发病率也在重新上升。因此,我们有必要了解全球为改善梅毒患者的医疗服务而采取的各种策略:本范围界定综述旨在确定和绘制影响梅毒患者获得医疗服务的障碍和促进因素:本范围界定综述将采用乔安娜-布里格斯研究所(Joanna Briggs Institute)概述的方法。将在多个数据库中进行检索,包括PubMed/MEDLINE、Scopus、Embase、LILACS(虚拟健康图书馆)和CINAHL(EBSCO)。此外,还将探索未发表的研究或灰色文献的来源。无论地理位置、国家或语言如何,重点关注梅毒患者获得医疗保健的研究都将被纳入。两名独立审稿人将对结果进行评估,并使用专门为本综述开发的工具提取数据。提取的定量数据将以表格的形式呈现,并采用降序分层分类法进行分析,以类目树枝图表示。障碍和促进因素将按访问维度进行分类:数据库搜索始于 2024 年 10 月。全文筛选和审查预计将于 2024 年 12 月完成。数据提取和分析预计将于 2025 年 2 月完成,最终报告将于 2025 年 3 月完成:在本方案的指导下,本次范围界定审查的结果将阐明影响梅毒治疗的主要障碍和促进因素。这项研究可能有助于卫生专业人员、管理人员和学术界的实践,并为民众提供相关信息:Open Science Framework Registries osf.io/kpsab;https://osf.io/kpsab.International registered report identifier (irrid):prr1-10.2196/63561。
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引用次数: 0
Development of a Mobile App for Occupational Stress Screening Among Female Workers: Protocol for an Exploratory Sequential Design Study. 为女工开发职业压力筛查移动应用程序:探索性顺序设计研究协议》。
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-14 DOI: 10.2196/55874
Dini Widianti, Zwasta Pribadi Mahardhika, Robiana Modjo

Background: Occupational safety hazards include physical, chemical, ergonomic, biological, and psychological hazards. Technological innovation in screening for occupational stress, especially among female workers, is needed to improve their health and productivity.

Objective: This research is being conducted to obtain a prediction model of work stress through a questionnaire instrument that includes stressors and symptoms based on the transactional model, as well as measurement of work stress through a mobile app that can be used anywhere.

Methods: The research is conducted in 3 stages: qualitative research, quantitative research (cross-sectional), and mobile app development. Data were collected from companies located in Jakarta, Indonesia. The sample was chosen based on purposive sampling. For the quantitative research (n=430), logistic regression analysis was used.

Results: We are developing a work stress screening instrument for female workers, which includes stressors and symptoms based on the transactional model, in the form of a digital platform so that female workers can undertake the examination anywhere without interfering with working hours or home duties. This research was funded in January 2024 and qualitative data collection began in February 2024. Quantitative data were obtained in March 2024; the number of respondents in the qualitative stage was 6, and in the quantitative stage it was 430. The work stress screening app is in the development stage and will be launched at the same time as the data collection is performed so we can examine the respondents' perspectives on the use of the app.

Conclusions: This study analyzes the prediction of work stress to help female workers screen for work stress. Workers who are detected as experiencing work stress will be educated using an algorithm programmed in the app.

International registered report identifier (irrid): PRR1-10.2196/55874.

背景:职业安全危害包括物理、化学、人体工程学、生物和心理危害。需要在职业压力筛查方面进行技术革新,特别是在女工中,以改善她们的健康和生产率:本研究旨在通过一种基于事务模型的问卷工具(包括压力源和症状)获得工作压力预测模型,并通过一种可在任何地方使用的移动应用程序测量工作压力:研究分三个阶段进行:定性研究、定量研究(横断面)和移动应用程序开发。数据从印度尼西亚雅加达的公司收集。样本的选择基于目的性抽样。定量研究(n=430)采用了逻辑回归分析法:我们正在开发一种针对女工的工作压力筛查工具,其中包括基于交易模型的压力源和症状,该工具采用数字平台的形式,使女工可以在任何地方进行检查,而不会影响工作时间或家务。这项研究于 2024 年 1 月获得资助,2024 年 2 月开始收集定性数据。定性阶段的受访者人数为 6 人,定量阶段的受访者人数为 430 人。工作压力筛查应用程序正处于开发阶段,将在数据收集的同时推出,这样我们就可以考察受访者对使用该应用程序的看法:本研究分析了工作压力的预测,以帮助女工筛查工作压力。国际注册报告标识符(irrid):PRR1-10.2196/55874。
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引用次数: 0
Phenotype-Genotype Correlation in Morquio A Syndrome: Protocol for a Meta-Analysis. Morquio A 综合征的表型-基因型相关性:元分析协议》。
IF 1.4 Q3 HEALTH CARE SCIENCES & SERVICES Pub Date : 2024-11-14 DOI: 10.2196/56649
Lorena Diaz-Ordoñez, Paola Andrea Duque-Cordoba, Daniel Andrés Nieva-Posso, Wilmar Saldarriaga, Juan David Gutierrez-Medina, Harry Pachajoa
<p><strong>Background: </strong>Mucopolysaccharidosis type IVA (MPS IVA), also known as Morquio A syndrome, is a rare lysosomal storage disease characterized by autosomal recessive inheritance of mutations in the N-acetylgalactosamine-6-sulfatase (GALNS) gene. This leads to a deficiency of the GALNS enzyme, causing the accumulation of glycosaminoglycans in tissues. Morquio A syndrome primarily affects the skeletal system and joints but can also impact various organs, resulting in symptoms such as hearing and vision loss, respiratory issues, spinal cord compression, heart diseases, and hepatomegaly. The genotype-phenotype relationship is diverse, with studies highlighting variants associated with classic, nonclassic, or intermediate phenotypes. Understanding these genetic factors is crucial for predicting disease prognosis and tailoring effective treatment strategies for individuals with Morquio A syndrome.</p><p><strong>Objective: </strong>The aim of this meta-analysis is to comprehend the relationship between the severity of the phenotype and the genotype of patients with MPS IVA, considering factors such as the type of variant and its location in the different domains of the protein.</p><p><strong>Methods: </strong>This meta-analysis will include articles featuring participants of all genders and age groups who have a molecular diagnosis of MPS IVA and a description of the phenotype. Literature published in English, Spanish, and Portuguese will be considered. Exclusion criteria will encompass studies lacking full-text availability and those involving patients with an MPS IVA diagnosis but without phenotype information. The databases to be searched include PubMed, MEDLINE, ScienceDirect, and Scopus. The screening of literature, paper selection, and data extraction will involve 2 independent reviewers, who will conduct the process blindly. In the event of disagreements between the 2 reviewers at any stage, resolution will be sought through discussion or with the involvement of an additional reviewer. The final selection of manuscripts will be based on consensus. The results of the review will be presented using descriptive statistics, and the information will be organized in either diagrammatic or tabular formats, following the guidelines provided by the Joanna Briggs Institute. Genotype-phenotype relationships will be analyzed using IBM SPSS Statistics, using chi-square tests, Fisher exact tests, and regression analysis to interpret the data.</p><p><strong>Results: </strong>A literature search conducted in January 2024 produced 760 results. The review is expected to be completed by the end of 2024.</p><p><strong>Conclusions: </strong>This meta-analysis will gather and analyze information on the phenotype-genotype relationship in patients diagnosed with MPS IVA. The data collection and resulting analyses will make a substantial contribution to understanding the underlying mechanism of the disease, enabling the prediction of the syndrome's progres
背景:粘多糖病 IVA 型(MPS IVA),又称 Morquio A 综合征,是一种罕见的溶酶体贮积病,其特征是 N-乙酰半乳糖胺-6-硫酸酯酶(GALNS)基因突变的常染色体隐性遗传。这会导致 GALNS 酶缺乏,造成组织中糖胺聚糖的积累。Morquio A 综合征主要影响骨骼系统和关节,但也会影响各种器官,导致听力和视力下降、呼吸系统问题、脊髓压迫、心脏病和肝肿大等症状。基因型与表型之间的关系多种多样,研究强调了与典型、非典型或中间表型相关的变异。了解这些遗传因素对于预测疾病预后和为莫基奥A综合征患者量身定制有效的治疗策略至关重要:本荟萃分析旨在了解 MPS IVA 患者的表型严重程度与基因型之间的关系,同时考虑变异类型及其在蛋白质不同结构域中的位置等因素:本荟萃分析将收录所有性别和年龄组的 MPS IVA 分子诊断参与者以及表型描述的文章。将考虑以英语、西班牙语和葡萄牙语发表的文献。排除标准包括未提供全文的研究,以及涉及已确诊为 MPS IVA 但未提供表型信息的患者的研究。检索的数据库包括 PubMed、MEDLINE、ScienceDirect 和 Scopus。文献筛选、论文选择和数据提取将由两名独立审稿人进行,他们将以盲审方式进行。如果两位审稿人在任何阶段出现意见分歧,将通过讨论或让另一位审稿人参与解决。稿件的最终选择将以协商一致为基础。根据乔安娜-布里格斯研究所(Joanna Briggs Institute)提供的指南,审稿结果将采用描述性统计方法,并以图表或表格形式组织信息。将使用 IBM SPSS 统计软件分析基因型与表型之间的关系,使用卡方检验、费雪精确检验和回归分析来解释数据:2024 年 1 月进行的文献检索产生了 760 项结果。综述预计将于 2024 年底完成:这项荟萃分析将收集和分析被诊断为 MPS IVA 患者的表型-基因型关系信息。数据收集和由此产生的分析结果将对了解该疾病的潜在机制做出重大贡献,从而能够预测该综合征的进展和严重程度:DERR1-10.2196/56649。
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