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Hyperuricemia is a biomarker of early mortality in patients with chronic obstructive pulmonary disease. 高尿酸血症是慢性阻塞性肺病患者早期死亡的生物标志物。
IF 2.8 Pub Date : 2015-11-26 eCollection Date: 2015-01-01 DOI: 10.2147/COPD.S87202
Xin Zhang, Lijie Liu, Rui Liang, Shoude Jin

Patients with chronic obstructive pulmonary disease (COPD) are often at high risk of early death. Identification of prognostic biomarkers for COPD may aid in improving their survival by providing early strengthened therapy for high-risk patients. In the present study, we investigated the prognostic role of hyperuricemia at baseline on the prognosis of patients with COPD. Thirty-four patients with COPD with hyperuricemia were matched (1:2) to 68 patients with COPD without hyperuricemia and of similar age and sex. Data from those patients with COPD were evaluated retrospectively. The role of hyperuricemia on mortality was first analyzed using the Kaplan-Meier method, and multivariate Cox regression model was then used to evaluate the prognostic significance of hyperuricemia in patients with COPD. Hyperuricemia was not associated with other baseline characteristics in patients with COPD. Kaplan-Meier survival curve showed that patients with COPD with hyperuricemia had higher risk of mortality compared with patients with normouricemia, and the P-value for log-rank test was 0.005. In univariate analysis, hyperuricemia was associated with higher risk of mortality in patients with COPD (hazard ratio =2.29, 95% CI =1.07-4.88, P=0.032). In the multivariate analysis, hyperuricemia was independently associated with higher risk of mortality in patients with COPD (hazard ratio =2.68, 95% CI =1.18-6.09, P=0.019). In conclusion, hyperuricemia is a promising biomarker of early mortality in patients with COPD.

慢性阻塞性肺病(COPD)患者往往面临早期死亡的高风险。确定慢性阻塞性肺病的预后生物标志物,可为高危患者提供早期强化治疗,从而帮助改善他们的生存状况。在本研究中,我们调查了基线高尿酸血症对慢性阻塞性肺病患者预后的影响。34 名患有慢性阻塞性肺病的高尿酸血症患者与 68 名无高尿酸血症且年龄和性别相似的慢性阻塞性肺病患者进行了配对(1:2)。对这些慢性阻塞性肺病患者的数据进行了回顾性评估。首先使用 Kaplan-Meier 法分析了高尿酸血症对死亡率的影响,然后使用多变量 Cox 回归模型评估了高尿酸血症在慢性阻塞性肺病患者中的预后意义。高尿酸血症与慢性阻塞性肺病患者的其他基线特征无关。卡普兰-米尔生存曲线显示,与正常尿酸血症患者相比,患有高尿酸血症的慢性阻塞性肺病患者的死亡风险更高,对数秩检验的 P 值为 0.005。在单变量分析中,高尿酸血症与 COPD 患者较高的死亡风险相关(危险比 =2.29,95% CI =1.07-4.88,P=0.032)。在多变量分析中,高尿酸血症与慢性阻塞性肺病患者较高的死亡风险独立相关(危险比 =2.68,95% CI =1.18-6.09,P=0.019)。总之,高尿酸血症是慢性阻塞性肺病患者早期死亡的一个有希望的生物标志物。
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引用次数: 0
[Peripherally inserted central catheters (PICC): a promising technique]. [外周插入中心导管(PICC):一种很有前途的技术]。
Pub Date : 2012-10-23 DOI: 10.3126/NJR.V2I1.6986
V. Vidal, A. Jacquier, O. Monnet, A. Varoquaux, T. Le Corroller, J. Gaubert, P. Champsaur, J. Bartoli, G. Moulin
To describe technical features and benefits from PICC lines.
描述人保保险线路的技术特点和效益。
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引用次数: 4
Échographie du tunnel tarsien : aspect normal et pathologique 跗骨隧道超声:正常和病理表现
Pub Date : 2011-12-01 DOI: 10.1016/j.jradio.2011.03.026
O. Fantino, J.-Y. Coillard, J. Borne, B. Bordet

Tarsal tunnel syndrome is a condition that is caused by compression of the tibial nerve or its associated branches. Diagnosis is based on clinical findings but imaging is performed to exclude a cause of compression, identified in 60 to 80% of cases. Ultrasound is a useful examination because of its high spatial resolution and ability to rapidly perform an axial survey of the nerves. The ultrasound imaging features of the tarsal tunnel are described. The etiologies and different types are illustrated through a review of clinical cases.

跗骨隧道综合征是一种由胫骨神经或其相关分支受压引起的疾病。诊断是基于临床表现,但影像学检查可以排除压迫的原因,在60%至80%的病例中可以确定。超声是一种有用的检查,因为它具有高空间分辨率和快速进行神经轴向检查的能力。本文描述了跗骨隧道的超声成像特征。病因和不同类型的说明,通过回顾临床病例。
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引用次数: 14
Occlusion de l’artère de Percheron : difficultés du diagnostic clinique et place de l’IRM. À propos de six cas Percheron动脉闭塞:临床诊断的困难和mri的应用。约六宗个案
Pub Date : 2011-12-01 DOI: 10.1016/j.jradio.2011.08.007
J.L. Lamboley , F. Le Moigne , L. Have , G. Tsouka , A. Drouet , P. Salamand , L. Guilloton

Blood supply to the human thalami is complex and multiple variants exist. The artery of Percheron is one of those variants and is characterized by a solitary arterial trunk that branches from one of the proximal segments of either posterior cerebral artery and supplies blood to the paramedian thalami. Its occlusion results in bilateral paramedian thalamic infarction sometimes extending to the midbrain. We report six cases of bithalamic infarction secondary to occlusion of the artery of Percheron. We will illustrate the complex clinical symptomatology and underscore the role of imaging, especially MRI, for diagnosis.

人类丘脑的血液供应是复杂的,存在多种变体。Percheron动脉是其中的一种变体,其特点是有一个孤立的动脉干,从大脑后动脉的近段分支出来,向丘脑旁脉供血。它的闭塞导致双侧丘脑旁脉梗死,有时延伸到中脑。我们报告6例继发于双丘脑梗死的动脉阻塞。我们将说明复杂的临床症状,并强调成像的作用,特别是MRI,为诊断。
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引用次数: 13
Origine anormale de la coronaire gauche à partir de l’artère pulmonaire : place du scanner 64 coupes 肺动脉左冠状动脉起源异常:扫描位置64切片
Pub Date : 2011-12-01 DOI: 10.1016/j.jradio.2011.05.015
M. Toussaint , P. Goube , V. Kuoch , C. Defrance , F. Amrar-Vennier , E. Nicollet , S. Gonin , F. Busy , H. Lardoux
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引用次数: 2
IRM mammaire en 2011 [2011年的乳房核磁共振成像]。
Pub Date : 2011-12-01 DOI: 10.1016/j.jradio.2011.11.001
A. Tardivon
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引用次数: 1
Dose patient en neuroradiologie interventionnelle : bilan d’une enquête multicentrique 介入神经放射学中的患者剂量:多中心调查的结果
Pub Date : 2011-12-01 DOI: 10.1016/j.jradio.2011.08.005
N. Kien, J.-L. Rehel, C. Étard, B. Aubert

Purpose

The purpose of this multicenter study was to determine the doses received by patients during interventional neuroradiology procedures and to consider establishing reference standards.

Materials and methods

A retrospective study of nine interventional neuroradiology departments was conducted. Seven diagnostic (cerebral and spinal angiography) and therapeutic (embolization and vertebroplasty) procedures were reviewed. For each procedure, three dosimetric parameters were recorded: dose-area product (DAP), fluoroscopy time, and number of images.

Results

Results showed interdepartment variations, up to four-fold for diagnostic procedures and seven-fold for therapeutic procedures. However, applying the 75th percentile method to the entire dataset, reference standards can be proposed for six types of procedures including diagnostic cerebral angiography (230 Gy cm2), follow-up selective cerebral angiography (80 Gy cm2), aneurysm embolization (350 Gy cm2), AVM embolization (440 Gy cm2). Reference standards are also proposed with regards to fluoroscopy time and number of images.

Conclusion

Such standards are useful for clinicians to evaluate and improve their practices.

目的本多中心研究的目的是确定患者在介入神经放射学手术中接受的剂量,并考虑建立参考标准。材料与方法对9个介入神经放射科进行回顾性研究。回顾了七种诊断(脑和脊髓血管造影)和治疗(栓塞和椎体成形术)的方法。对于每个程序,记录三个剂量学参数:剂量面积积(DAP),透视时间和图像数量。结果显示科室间差异,诊断程序高达4倍,治疗程序高达7倍。然而,将第75个百分点方法应用于整个数据集,可以提出六种手术的参考标准,包括诊断性脑血管造影(230 Gy cm2),随访选择性脑血管造影(80 Gy cm2),动脉瘤栓塞(350 Gy cm2), AVM栓塞(440 Gy cm2)。同时提出了关于透视时间和图像数量的参考标准。结论该标准对临床医生评价和改进临床实践有一定的参考价值。
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引用次数: 22
Artefacts et pièges en IRM mammaire 乳房mri中的人工制品和陷阱
Pub Date : 2011-12-01 DOI: 10.1016/j.jradio.2011.09.009
C. Salem , J. Chopier , N. Perrot , E. Darai , I. Thomassin-Naggara

Multiple artefacts and pitfalls may occur with breast MRI. Artefacts are secondary to the MR technique itself while pitfalls often are the result of human error. The most common artefacts include motion, pulsation, chemical shift and magnetic susceptibility. The most common pitfalls include improper contrast injection, poor patient positioning, improper placement of the ROI and improper characterization of physiological and iatrogenic contrast enhancement. The identification of these artefacts and pitfalls on breast MR images may reduce their impact or even eliminate them. The use of optimized protocols is necessary. It is important to explain to patients the sequence of the examination, ensure proper placement of the breasts in the coil and optimize the contrast injection. The ROI should always be placed over the most suspicious region of the lesion. Finally, it is recommended to perform the MRI during the second week of the menstrual cycle and to discontinue the use of HRT 2 months prior to scanning when possible.

乳房MRI可能出现多重伪影和陷阱。相对于MR技术本身,工件是次要的,而陷阱通常是人为错误的结果。最常见的伪影包括运动、脉动、化学位移和磁化率。最常见的缺陷包括造影剂注射不当,患者体位不良,ROI放置不当以及生理性和医源性造影剂增强的特征不正确。在乳房磁共振图像上识别这些伪影和陷阱可以减少它们的影响,甚至消除它们。使用优化的协议是必要的。向患者解释检查顺序,确保乳房在线圈中的正确位置,优化造影剂注射是很重要的。ROI应始终放置在病变最可疑的区域。最后,建议在月经周期的第二周进行MRI检查,如果可能的话,在扫描前2个月停止使用HRT。
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引用次数: 2
Évaluation de l’apport de l’échographie de contraste dans l’analyse des kystes rénaux de nature indéterminée au scanner 对比超声在扫描仪分析不确定肾囊肿中的作用评价
Pub Date : 2011-12-01 DOI: 10.1016/j.jradio.2011.09.008
X. Cazals , A. Bleuzen , F. Tranquart , A. Aljishi , F. Bruyère , B. Faivre d’Arcier , F. Patat , L. Brunereau

Purpose

To demonstrate the value of contrast-enhanced ultrasound (CEUS) in the management of Bosniak type 2F and 3 renal cysts on CT.

Patients and methods

Retrospective study of 14 patients with 15 Bosniak type 2F and 3 renal cysts on contrast enhanced CT. All patients underwent CEUS of the kidneys after injection of SonoVue®. Using predetermined criteria, the lesions were classified as benign, malignant or indeterminate. Patients either underwent surgery or follow-up CT at one to three years.

Results

From the 15 indeterminate cysts on CT, 12 were either benign (n = 8) or malignant (n = 4) on CEUS. From the eight cysts considered benign on CEUS, seven remained stable on follow-up CT after a minimum of one year interval and one was surgically resected and confirmed to be benign. All four cysts considered malignant on CEUS were surgically resected and three were confirmed to be malignant and one was confirmed to be benign. Three cysts were indeterminate: two lesions were surgically resected and one was benign while the other was malignant and one lesion was stable at one year follow-up CT.

Conclusion

CEUS was able to characterize indeterminate lesions as benign or malignant in 80% of cases with 92% reliability. Twenty percent of cysts remained indeterminate on CEUS. CEUS is reliable as a complement to CT in the evaluation of Bosniak type 2F and 3 renal cysts.

目的探讨超声造影(CEUS)对Bosniak 2F型和3型肾囊肿的CT诊断价值。患者与方法回顾性分析14例15例Bosniak 2F型肾囊肿及3例肾囊肿的增强CT表现。所有患者在注射SonoVue®后均行肾脏超声造影。使用预先确定的标准,将病变分为良性、恶性或不确定。患者要么接受手术,要么在一到三年内接受CT随访。结果15例CT表现不明确的囊肿中,超声造影显示12例为良性(8例)或恶性(4例)。在CEUS上被认为是良性的8个囊肿中,7个在随访CT上至少间隔1年后保持稳定,1个被手术切除并确认为良性。所有四个超声造影认为是恶性的囊肿都被手术切除,其中三个被确认为恶性,一个被确认为良性。3个囊肿不确定:2个病变手术切除,1个为良性,1个为恶性,1个病变随访1年CT稳定。结论超声造影诊断不明确病变为良恶性的准确率为80%,可靠性为92%。20%的囊肿在超声造影上仍不确定。超声造影是评价Bosniak 2F型和3型肾囊肿的可靠补充。
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引用次数: 8
Torsion pulmonaire après œsophagectomie : une complication rare et vitale 食道切除术后肺扭转:一种罕见而重要的并发症
Pub Date : 2011-12-01 DOI: 10.1016/j.jradio.2011.05.014
E. Frampas , N. Regenet , G. Meurette , D. Demeure , B. Dupas
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引用次数: 1
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Journal De Radiologie
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