Pub Date : 2024-06-10DOI: 10.9734/jammr/2024/v36i65476
Bruno Fongaro Dalbosco, Poliana Maria de Faveri Cardoso, Carlos Eduardo Misiak Godoy, Júlio Katuhide Ueda, Francisco Ubiratan Ferreira de Campos, Veridiana Camilotti
Aims: To evaluate the efficacy of ozonated sunflower oil in managing sensitivity during and after in-office dental bleaching. Methodology: Thirty patients were selected and allocated into two distinct groups - 5% Potassium Nitrate and 2% Sodium Fluoride (NF) and ozonated sunflower oil (OGO). Desensitization was performed before the application of the bleaching gel for 10 minutes. Hydrogen peroxide was applied for 30 minutes. The evaluation of the degree of sensitivity (DS) was performed on an illustrative scale from 0 to 4, and the patients were questioned during bleaching (05 minutes, 10 minutes, 15 minutes, 20 minutes, 25 minutes, and 30 minutes) and after bleaching (1 hour, 24 hours, 48 hours and 7 days). The degree of whitening (DW) was assessed before and 7 days after treatment. The data were subjected to Wilcoxon statistical analysis (p<0.05). Results: In the intra-group analysis, there was a statistical difference between the times. In the inter-group analysis, ozonated sunflower oil compared to the conventional desensitizing agent resulted in statistical differences for the times of 25 minutes, 30 minutes and 1 hour post-bleaching. In the color saturation analysis, both groups showed statistical differences between the initial color and the final color. Conclusion: Ozonated sunflower oil demonstrates significant management of sensitivity during and after in-office dental bleaching, in addition to not interfering with the degree of color saturation of the bleached teeth and the efficiency of hydrogen peroxide.
{"title":"Effectiveness of Different Desensitizing Protocols in In-Office Dental Whitening: Clinical, Blind and Randomized Study","authors":"Bruno Fongaro Dalbosco, Poliana Maria de Faveri Cardoso, Carlos Eduardo Misiak Godoy, Júlio Katuhide Ueda, Francisco Ubiratan Ferreira de Campos, Veridiana Camilotti","doi":"10.9734/jammr/2024/v36i65476","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i65476","url":null,"abstract":"Aims: To evaluate the efficacy of ozonated sunflower oil in managing sensitivity during and after in-office dental bleaching. \u0000Methodology: Thirty patients were selected and allocated into two distinct groups - 5% Potassium Nitrate and 2% Sodium Fluoride (NF) and ozonated sunflower oil (OGO). Desensitization was performed before the application of the bleaching gel for 10 minutes. Hydrogen peroxide was applied for 30 minutes. The evaluation of the degree of sensitivity (DS) was performed on an illustrative scale from 0 to 4, and the patients were questioned during bleaching (05 minutes, 10 minutes, 15 minutes, 20 minutes, 25 minutes, and 30 minutes) and after bleaching (1 hour, 24 hours, 48 hours and 7 days). The degree of whitening (DW) was assessed before and 7 days after treatment. The data were subjected to Wilcoxon statistical analysis (p<0.05). \u0000Results: In the intra-group analysis, there was a statistical difference between the times. In the inter-group analysis, ozonated sunflower oil compared to the conventional desensitizing agent resulted in statistical differences for the times of 25 minutes, 30 minutes and 1 hour post-bleaching. In the color saturation analysis, both groups showed statistical differences between the initial color and the final color. \u0000Conclusion: Ozonated sunflower oil demonstrates significant management of sensitivity during and after in-office dental bleaching, in addition to not interfering with the degree of color saturation of the bleached teeth and the efficiency of hydrogen peroxide.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"121 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141360524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-10DOI: 10.9734/jammr/2024/v36i65475
Leonardo Diniz Resende, Luiz Adriano Teixeira do Rego Barros, L. Pavesi, W. Sendyk, Yeon Jung Kim, D. Pallos
Background: Chronic Kidney Disease is prevalent in the general population and is associated with high morbidity and mortality and its pathogenic mechanisms are related to pro-inflammatory cytokines, such as Interleukin 6 (IL-6). It is known that polymorphisms associated with IL-6 can trigger a different immune response in the individual and therefore be a determining factor in the progression of the disease. The idea of using saliva as an analysis matrix for diagnostic methods suggests that the methodology may be viable due to the easy way collection of these fluids and the amount of information in saliva molecular constituents. Aims: To identify the relationship between IL-6 polymorphism (-174) in dialysis patients using saliva. Methodology: 53 individuals were assessed, divided into a test group: 27 on hemodialysis; and a control group: 26 healthy individuals. Saliva samples were collected, DNA was extracted, and genotyping was performed using Real Time-Polymerase Chain Reaction (RT-PCR). For statistical analysis, the c2 was performed on categorical data. Results: The genotype frequency identified was 33.33% GC, 59.25% GG and 7.42% CC for the hemodialysis group and 19.23% GC, 50% GG and 30.77% CC for the healthy group(p=0.0806). Conclusion: It was possible to verify the presence of the IL-6 (-174) polymorphism in saliva. Nonetheless, the predominance of GG was not significant, corroborating with other studies, that also indicate no relation between IL-6 Polymorphism and CKD. In this study, it was not possible to correlate hemodialysis patients with the polymorphism studied, but more studies about this subject are necessary, mainly in countries with diverse population, as Brazil.
{"title":"Identification of the Interleukin-6 Polymorphism (-174) in the Saliva of Hemodialysis Patients","authors":"Leonardo Diniz Resende, Luiz Adriano Teixeira do Rego Barros, L. Pavesi, W. Sendyk, Yeon Jung Kim, D. Pallos","doi":"10.9734/jammr/2024/v36i65475","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i65475","url":null,"abstract":"Background: Chronic Kidney Disease is prevalent in the general population and is associated with high morbidity and mortality and its pathogenic mechanisms are related to pro-inflammatory cytokines, such as Interleukin 6 (IL-6). It is known that polymorphisms associated with IL-6 can trigger a different immune response in the individual and therefore be a determining factor in the progression of the disease. The idea of using saliva as an analysis matrix for diagnostic methods suggests that the methodology may be viable due to the easy way collection of these fluids and the amount of information in saliva molecular constituents.\u0000Aims: To identify the relationship between IL-6 polymorphism (-174) in dialysis patients using saliva.\u0000Methodology: 53 individuals were assessed, divided into a test group: 27 on hemodialysis; and a control group: 26 healthy individuals. Saliva samples were collected, DNA was extracted, and genotyping was performed using Real Time-Polymerase Chain Reaction (RT-PCR). For statistical analysis, the c2 was performed on categorical data.\u0000Results: The genotype frequency identified was 33.33% GC, 59.25% GG and 7.42% CC for the hemodialysis group and 19.23% GC, 50% GG and 30.77% CC for the healthy group(p=0.0806).\u0000Conclusion: It was possible to verify the presence of the IL-6 (-174) polymorphism in saliva. Nonetheless, the predominance of GG was not significant, corroborating with other studies, that also indicate no relation between IL-6 Polymorphism and CKD. In this study, it was not possible to correlate hemodialysis patients with the polymorphism studied, but more studies about this subject are necessary, mainly in countries with diverse population, as Brazil.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"123 28","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141361762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-10DOI: 10.9734/jammr/2024/v36i65477
Lucas Pessoa Souza, Pedro Figueiredo Martins Ribeir, Roberto Cesar Lima Santos, Rodolfo Feitosa de Figueiredo Moreira, Petrus Moura Andrade Lima, Leslie Clifford Noronha Araujo
Aim: The aim of this study is to analyze concepts and updates on Damage Control Resuscitation (DCR), focusing on critical patient approaches, therapeutic failures identification, and the relevance of damage control in trauma. Methods: This article presents a systematic review of damage control resuscitation in trauma, encompassing both consolidated and emerging literature, using informative tables in accordance with PRISMA 2020 guidelines. Conducted between March 2023 and March 2024, using the research descriptor "Resuscitation for damage control" in PubMed. Studies published between 2016 and 2023, freely accessible in English and Portuguese, were included, while those not aligning with the objective were excluded. Out of 979 articles found, 10 were selected after applying inclusion and exclusion criteria. Results: Damage Control Resuscitation (DCR) is based on three pillars: permissive hypotension, minimization of crystalloid use, and balanced resuscitation. This approach aims to maintain adequate blood pressure, limit crystalloid use to avoid complications, and balance blood product transfusion. Hypocalcemia has emerged as a new challenge in the lethal triad of trauma, impacting coagulation and mortality. New techniques, such as REBOA and viscoelastic tests (TEG and ROTEM), are being explored to improve resuscitation in severe trauma cases. Tranexamic acid (TXA) also stands out as an effective treatment for excessive bleeding in trauma situations. The importance of pre-hospital care and early interventions is emphasized to optimize bleeding control and resuscitation in traumatized patients. Conclusion: Damage Control Resuscitation (DCR) is an evidence-based strategy for treating traumatized patients, focusing on permissive hypotension, reduced crystalloid use, and balanced transfusion. In resource-limited settings, alternatives such as whole blood use can be adopted. Pre-hospital care and early interventions are crucial for better outcomes and survival.
{"title":"Damage Control Resuscitation: Evidence-based Systematic Review for Treating Traumatized Patients","authors":"Lucas Pessoa Souza, Pedro Figueiredo Martins Ribeir, Roberto Cesar Lima Santos, Rodolfo Feitosa de Figueiredo Moreira, Petrus Moura Andrade Lima, Leslie Clifford Noronha Araujo","doi":"10.9734/jammr/2024/v36i65477","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i65477","url":null,"abstract":"Aim: The aim of this study is to analyze concepts and updates on Damage Control Resuscitation (DCR), focusing on critical patient approaches, therapeutic failures identification, and the relevance of damage control in trauma. \u0000Methods: This article presents a systematic review of damage control resuscitation in trauma, encompassing both consolidated and emerging literature, using informative tables in accordance with PRISMA 2020 guidelines. Conducted between March 2023 and March 2024, using the research descriptor \"Resuscitation for damage control\" in PubMed. Studies published between 2016 and 2023, freely accessible in English and Portuguese, were included, while those not aligning with the objective were excluded. Out of 979 articles found, 10 were selected after applying inclusion and exclusion criteria. \u0000Results: Damage Control Resuscitation (DCR) is based on three pillars: permissive hypotension, minimization of crystalloid use, and balanced resuscitation. This approach aims to maintain adequate blood pressure, limit crystalloid use to avoid complications, and balance blood product transfusion. Hypocalcemia has emerged as a new challenge in the lethal triad of trauma, impacting coagulation and mortality. New techniques, such as REBOA and viscoelastic tests (TEG and ROTEM), are being explored to improve resuscitation in severe trauma cases. Tranexamic acid (TXA) also stands out as an effective treatment for excessive bleeding in trauma situations. The importance of pre-hospital care and early interventions is emphasized to optimize bleeding control and resuscitation in traumatized patients. \u0000Conclusion: Damage Control Resuscitation (DCR) is an evidence-based strategy for treating traumatized patients, focusing on permissive hypotension, reduced crystalloid use, and balanced transfusion. In resource-limited settings, alternatives such as whole blood use can be adopted. Pre-hospital care and early interventions are crucial for better outcomes and survival.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141366259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-08DOI: 10.9734/jammr/2024/v36i65473
Magali de Fátima Pereira Madureira, C. Reis, Fabricio Fernandes Ferreira, Alessandra Esteves, W. C. R. Júnior, E. Küchler, Daniela Silva Barroso de Oliveira, Tomaz Henrique Araújo
Aim: The aim of this study was to evaluate the impact of testosterone (T) suppression during puberty on the development of dental, periodontal and alveolar structures in rats. Materials and Methods: Thirty-six Wistar rats were selected for this study. Orchiectomy (ORX) was performed on the animals of the experimental group (n=18) and sham surgery on the animals of the control group (n=18) on the 23rd day of life. The animals were allocated into 4 groups: an ORX group (n=9) and a sham group (n=9) euthanized at 45 days of age, and the other ORX group (n=9) and the other sham (n=9) euthanized at 73 days of age. After the experimental period, the animals were euthanized and the mandibles and maxillas were removed, dissected and fixed in 10% formalin, decalcified, cut at 7 µm and stained with hematoxylin and eosin and picrosirius red. Qualitative analysis of slides stained with Hematoxylin and Eosin were performed, while collagen synthesis obtained from slides stained with Red Silver was quantitatively evaluated using ImageJ software. Collagen synthesis was compared between groups using the student's t test using the IBM SPSS software. Results: Histologically, the animals submitted to orchiectomy showed variations in the periodontal region, immature alveolar bone and periodontal ligament with the presence of atypical fat cells, in the dental structures, hyperemic pulp with calcification points (nodules) and variation in the arrangement and shape of the odontoblasts, with considerable significance when compared with the animals of the Sham group. Conclusion: In conclusion, the testosterone suppression induces changes in the differentiation of cells that form the tissues of dental and alveolar structures, through the incidence of pulp alterations, presence of atypical cells in the periodontal ligament and delay in the neoformation of alveolar bone in rats during puberty.
{"title":"The Impact of Testosterone Suppression on Dental Structures: An In vivo Study","authors":"Magali de Fátima Pereira Madureira, C. Reis, Fabricio Fernandes Ferreira, Alessandra Esteves, W. C. R. Júnior, E. Küchler, Daniela Silva Barroso de Oliveira, Tomaz Henrique Araújo","doi":"10.9734/jammr/2024/v36i65473","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i65473","url":null,"abstract":"Aim: The aim of this study was to evaluate the impact of testosterone (T) suppression during puberty on the development of dental, periodontal and alveolar structures in rats. \u0000Materials and Methods: Thirty-six Wistar rats were selected for this study. Orchiectomy (ORX) was performed on the animals of the experimental group (n=18) and sham surgery on the animals of the control group (n=18) on the 23rd day of life. The animals were allocated into 4 groups: an ORX group (n=9) and a sham group (n=9) euthanized at 45 days of age, and the other ORX group (n=9) and the other sham (n=9) euthanized at 73 days of age. After the experimental period, the animals were euthanized and the mandibles and maxillas were removed, dissected and fixed in 10% formalin, decalcified, cut at 7 µm and stained with hematoxylin and eosin and picrosirius red. Qualitative analysis of slides stained with Hematoxylin and Eosin were performed, while collagen synthesis obtained from slides stained with Red Silver was quantitatively evaluated using ImageJ software. Collagen synthesis was compared between groups using the student's t test using the IBM SPSS software. \u0000Results: Histologically, the animals submitted to orchiectomy showed variations in the periodontal region, immature alveolar bone and periodontal ligament with the presence of atypical fat cells, in the dental structures, hyperemic pulp with calcification points (nodules) and variation in the arrangement and shape of the odontoblasts, with considerable significance when compared with the animals of the Sham group. \u0000Conclusion: In conclusion, the testosterone suppression induces changes in the differentiation of cells that form the tissues of dental and alveolar structures, through the incidence of pulp alterations, presence of atypical cells in the periodontal ligament and delay in the neoformation of alveolar bone in rats during puberty.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":" 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141370723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Intraoperative complications during thoracic procedures requiring one-lung ventilation (OLV) are rare but life-threatening. Double-lumen endotracheal tubes (DLTs) are commonly used but can lead to complications such as bilateral tension pneumothorax, posing significant challenges for anesthesiologists and thoracic surgeons. This case report highlights a critical incident during a mediastinoscopy under general anesthesia with OLV. Case Presentation: A 43-year-old male with a history of Hodgkin’s lymphoma underwent a mediastinoscopy. Anesthesia induction and intubation with a 37 French Carlen DLT were performed. Shortly after initiating OLV, the patient experienced sudden hypoxemia (SpO2 65%), increased peak airway pressures, bradycardia, and hypotension. Bilateral tension pneumothorax with subcutaneous emphysema was diagnosed, and emergency bilateral chest drain insertion stabilized the patient. Discussion: This case illustrates the severity of DLT-associated complications, particularly tension pneumothorax caused by tube malpositioning and barotrauma. Diagnosing tension pneumothorax is challenging due to similar symptoms with other intraoperative issues. Clinical signs include severe hypoxemia, hypercarbia, hypotension, and increased airway pressures. Rapid diagnosis through chest X-rays and ultrasonography, along with immediate management, such as chest drain insertion, is crucial. Conclusion: The case emphasizes the importance of vigilance and preparedness to manage anesthetic complications during thoracic procedures. Rigorous verification of DLT positioning, continuous monitoring, and prompt interventions are essential to prevent catastrophic events.
简介：在需要单肺通气（OLV）的胸腔手术中，术中并发症非常罕见，但却危及生命。双腔气管插管（DLT）是常用的气管插管，但可能导致双侧张力性气胸等并发症，给麻醉师和胸外科医生带来巨大挑战。本病例报告重点介绍了在使用 OLV 全身麻醉下进行纵隔镜检查时发生的一起危急事件。病例介绍：一名 43 岁的男性接受了纵隔镜检查，他有霍奇金淋巴瘤病史。使用 37 French Carlen DLT 进行了麻醉诱导和插管。开始 OLV 后不久，患者突然出现低氧血症（SpO2 65%）、气道峰压升高、心动过缓和低血压。诊断为双侧张力性气胸伴皮下气肿，紧急插入双侧胸腔引流管后患者病情稳定。讨论：本病例说明了 DLT 相关并发症的严重性，尤其是插管位置不当和气压创伤导致的张力性气胸。由于张力性气胸的症状与其他术中问题相似，因此诊断张力性气胸具有挑战性。临床症状包括严重低氧血症、高碳酸血症、低血压和气道压力增高。通过胸部 X 光和超声波检查快速确诊并立即进行处理（如插入胸腔引流管）至关重要。结论：该病例强调了在胸腔手术中提高警惕和做好准备以处理麻醉并发症的重要性。严格验证 DLT 定位、持续监测和及时干预对于防止灾难性事件的发生至关重要。
{"title":"Management of Bilateral Tension Pneumothorax with Extensive Subcutaneous Emphysema during One-Lung Ventilation","authors":"Tarik Baadi, Toufik Kachani, Achraf Jeddab, Mohammed Bhairis, Mouncif Choubhi, Mouaad Amraoui, Khalil Abou Elalaa","doi":"10.9734/jammr/2024/v36i65474","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i65474","url":null,"abstract":"Introduction: Intraoperative complications during thoracic procedures requiring one-lung ventilation (OLV) are rare but life-threatening. Double-lumen endotracheal tubes (DLTs) are commonly used but can lead to complications such as bilateral tension pneumothorax, posing significant challenges for anesthesiologists and thoracic surgeons. This case report highlights a critical incident during a mediastinoscopy under general anesthesia with OLV. \u0000Case Presentation: A 43-year-old male with a history of Hodgkin’s lymphoma underwent a mediastinoscopy. Anesthesia induction and intubation with a 37 French Carlen DLT were performed. Shortly after initiating OLV, the patient experienced sudden hypoxemia (SpO2 65%), increased peak airway pressures, bradycardia, and hypotension. Bilateral tension pneumothorax with subcutaneous emphysema was diagnosed, and emergency bilateral chest drain insertion stabilized the patient. \u0000Discussion: This case illustrates the severity of DLT-associated complications, particularly tension pneumothorax caused by tube malpositioning and barotrauma. Diagnosing tension pneumothorax is challenging due to similar symptoms with other intraoperative issues. Clinical signs include severe hypoxemia, hypercarbia, hypotension, and increased airway pressures. Rapid diagnosis through chest X-rays and ultrasonography, along with immediate management, such as chest drain insertion, is crucial. \u0000Conclusion: The case emphasizes the importance of vigilance and preparedness to manage anesthetic complications during thoracic procedures. Rigorous verification of DLT positioning, continuous monitoring, and prompt interventions are essential to prevent catastrophic events.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":" 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141370787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-07DOI: 10.9734/jammr/2024/v36i65469
Shahroz M. Khan, Farhana Nazmin, Rubela Ray, Rauann Hachem, Briannah Wade, Manal A. Bhinder, Muhammad B. Chaudhry, Marya Syed, Ayesha Khan, Eman Fatima, Imdad Ullah
Chronic hepatitis C with cirrhosis is treated with direct-acting antibiotics (DAAs). The aim of this study was to investigate the effect of direct-acting antibodies in the treatment of hepatitis C in cirrhosis. It also examines the proportion of drug-related problems, side effects, and mortality. The Cochrane Library and PubMed were thoroughly searched for the required literature. Fifteen articles were extracted for inclusion in this systematic review and meta-analysis. A total of 16 studies were thoroughly screened. The included studies provided a comprehensive picture of the effects of DAA therapy, spanning multiple study designs and sites Our analysis showed that good responses were observed with DAA regimens and that treatment discontinuation was low due to adverse events a stirring that. Few adverse events were reported, but all were mostly uncontrolled to prevent treatment discontinuation or death. In addition, meta-analytic studies on specific outcomes such as encephalopathy, ascites, hepatocellular carcinoma (HCC), adverse events, and death provided quantitative analysis about the safety of DAAs. Research also shows that DAAs have fewer side effects, deaths, and complications than other treatments.
{"title":"Direct-Acting Antivirals' Safety Profile in Patients with Advanced Liver Cirrhosis with Hepatitis C: A Systematic Review and Meta-Analysis","authors":"Shahroz M. Khan, Farhana Nazmin, Rubela Ray, Rauann Hachem, Briannah Wade, Manal A. Bhinder, Muhammad B. Chaudhry, Marya Syed, Ayesha Khan, Eman Fatima, Imdad Ullah","doi":"10.9734/jammr/2024/v36i65469","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i65469","url":null,"abstract":"Chronic hepatitis C with cirrhosis is treated with direct-acting antibiotics (DAAs). The aim of this study was to investigate the effect of direct-acting antibodies in the treatment of hepatitis C in cirrhosis. It also examines the proportion of drug-related problems, side effects, and mortality. The Cochrane Library and PubMed were thoroughly searched for the required literature. Fifteen articles were extracted for inclusion in this systematic review and meta-analysis. A total of 16 studies were thoroughly screened. The included studies provided a comprehensive picture of the effects of DAA therapy, spanning multiple study designs and sites Our analysis showed that good responses were observed with DAA regimens and that treatment discontinuation was low due to adverse events a stirring that. Few adverse events were reported, but all were mostly uncontrolled to prevent treatment discontinuation or death. In addition, meta-analytic studies on specific outcomes such as encephalopathy, ascites, hepatocellular carcinoma (HCC), adverse events, and death provided quantitative analysis about the safety of DAAs. Research also shows that DAAs have fewer side effects, deaths, and complications than other treatments.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141373682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-07DOI: 10.9734/jammr/2024/v36i65470
M. Provenzano, Tuane-Mertz Lucietto, G. Santin, Sandra-Kiss Moura, Adilson-Luiz Ramos
Aim: To evaluate the effect of educational/preventive measures in adolescents who wore fixed orthodontic appliances. Study Design: Prospective, controlled, and randomized clinical study. Place and Duration of Study: The adolescents were evaluated in a private dental clinic in the city of Ibiporã - PR for 12 weeks in 2015. Methodology: A randomized design, with records of plaque, gingival and bleeding indices. In total 40 adolescent patients, with an average age of 14 years, of both genders were selected at a private orthodontic clinic. Mechanical biofilm control was performed and oral hygiene kits were distributed. Clinical evaluations were made at the beginning of the study (baseline) and at time intervals of 30, 60 and 90 days, in a total of 12 weeks. Means of indices were compared throughout the study period. Among the educational/preventive measures used were photograph albums, verbal oral hygiene guidance and disclosing of dental plaque. Records were made of the participants’ oral hygiene habits. Results: The girls presented a higher dental plaque reduction value of 30.8% whereas the boys presented 25.3%. The plaque index showed significant reduction in the initial evaluation (baseline) and in the following re-evaluations at 30, 60 and 90 days. Conclusion: The educational/preventive measures used were shown to be effective, in view of the significant reduction in gingival inflammation and dental plaque indices, with improvement in the oral health of adolescents who wore fixed orthodontic appliances.
{"title":"The Effect of an Educational/ Preventive Program on Adolescents Undergoing Fixed Orthodontic Treatment: A Clinical Study","authors":"M. Provenzano, Tuane-Mertz Lucietto, G. Santin, Sandra-Kiss Moura, Adilson-Luiz Ramos","doi":"10.9734/jammr/2024/v36i65470","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i65470","url":null,"abstract":"Aim: To evaluate the effect of educational/preventive measures in adolescents who wore fixed orthodontic appliances. \u0000Study Design: Prospective, controlled, and randomized clinical study. \u0000Place and Duration of Study: The adolescents were evaluated in a private dental clinic in the city of Ibiporã - PR for 12 weeks in 2015. \u0000Methodology: A randomized design, with records of plaque, gingival and bleeding indices. In total 40 adolescent patients, with an average age of 14 years, of both genders were selected at a private orthodontic clinic. Mechanical biofilm control was performed and oral hygiene kits were distributed. Clinical evaluations were made at the beginning of the study (baseline) and at time intervals of 30, 60 and 90 days, in a total of 12 weeks. Means of indices were compared throughout the study period. Among the educational/preventive measures used were photograph albums, verbal oral hygiene guidance and disclosing of dental plaque. Records were made of the participants’ oral hygiene habits. \u0000Results: The girls presented a higher dental plaque reduction value of 30.8% whereas the boys presented 25.3%. The plaque index showed significant reduction in the initial evaluation (baseline) and in the following re-evaluations at 30, 60 and 90 days. \u0000Conclusion: The educational/preventive measures used were shown to be effective, in view of the significant reduction in gingival inflammation and dental plaque indices, with improvement in the oral health of adolescents who wore fixed orthodontic appliances.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141371353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-07DOI: 10.9734/jammr/2024/v36i65471
H. Benjelloun, Safia Rachid, A. Rattal, H. Harraz, N. Zaghba, K. Chaanoun, N. Yassine
The present study reports about recurrent spontaneous pneumothorax revealing Marfan syndrome. Marfan syndrome is a rare autosomal dominant disease that affects connective tissue and affects several organs, including the lung. It appears at a variable age and can be unrefined. This is a case of patient aged 16 years, eldest of two siblings, without toxic habits, treated for pulmonary tuberculosis confirmed bacteriologically 2 years ago and operated on 5 years ago for a left inguino-scrotal hernia. The patient presented to the department on day 7 after discharge following spontaneous stabbing left chest pain associated with dyspnea at the slightest effort. On clinical examination, there was a syndrome of air effusion in the left hemithorax. The frontal chest X-ray revealed a large total left pneumothorax which was drained. Lung involvement rarely modifies the respiratory functional prognosis. The occurrence of a pneumothorax is rarely a mode of entry into the disease, hence the interest in discussing the diagnosis in cases of recurrent spontaneous pneumothorax or thoracic deformation.
本研究报告揭示了马凡综合征的复发性自发性气胸。马凡综合征是一种罕见的常染色体显性遗传病，会影响结缔组织并累及多个器官，包括肺部。该病的发病年龄不定，也可能是非特异性的。本例患者 16 岁，是两个兄弟姐妹中的老大，无中毒习惯，2 年前曾因肺结核接受细菌学确诊治疗，5 年前曾因左侧腹股沟阴囊疝接受手术治疗。出院后第 7 天，患者因自发性左胸部刺痛，稍一用力就出现呼吸困难而到该科就诊。临床检查发现，患者左侧半胸腔存在气胸综合征。正面胸部 X 光片显示左侧有一个巨大的全气胸，已进行了引流。肺部受累很少会改变呼吸功能的预后。气胸的发生很少会成为疾病的诱因，因此我们有兴趣讨论复发性自发性气胸或胸廓变形病例的诊断。
{"title":"Recurrent Spontaneous Pneumothorax Revealing Marfan Syndrome: A Case Report","authors":"H. Benjelloun, Safia Rachid, A. Rattal, H. Harraz, N. Zaghba, K. Chaanoun, N. Yassine","doi":"10.9734/jammr/2024/v36i65471","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i65471","url":null,"abstract":"The present study reports about recurrent spontaneous pneumothorax revealing Marfan syndrome. Marfan syndrome is a rare autosomal dominant disease that affects connective tissue and affects several organs, including the lung. It appears at a variable age and can be unrefined. This is a case of patient aged 16 years, eldest of two siblings, without toxic habits, treated for pulmonary tuberculosis confirmed bacteriologically 2 years ago and operated on 5 years ago for a left inguino-scrotal hernia. The patient presented to the department on day 7 after discharge following spontaneous stabbing left chest pain associated with dyspnea at the slightest effort. On clinical examination, there was a syndrome of air effusion in the left hemithorax. The frontal chest X-ray revealed a large total left pneumothorax which was drained. Lung involvement rarely modifies the respiratory functional prognosis. The occurrence of a pneumothorax is rarely a mode of entry into the disease, hence the interest in discussing the diagnosis in cases of recurrent spontaneous pneumothorax or thoracic deformation.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141374473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-07DOI: 10.9734/jammr/2024/v36i65472
Nkiruka Lauretta Nwangene
Effective communication is essential for patient safety and successful outcomes of surgical procedures. Informed by the need for quality improvement in patient-anesthesiologist interrelations in a multilingual environment, this study dissects the barriers to effective communication, which confront anesthesiologists in the multilingual environment, as in Nigeria. The study proposes language-based techniques as the panacea for linguistic diversity, solecism, complex medical diction, and cultural and other barriers. The proposal is rooted in the Plan-Do-Study-Act framework. It concludes that where barriers to effective communication are duly addressed, improved patient-anesthesiologist communication, ethical professionalism, efficient performance and timely quality service delivery would obtain.
{"title":"Communication Barriers Encountered by Anesthesiologists in a Multilingual Environment: The Nigerian Case Study","authors":"Nkiruka Lauretta Nwangene","doi":"10.9734/jammr/2024/v36i65472","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i65472","url":null,"abstract":"Effective communication is essential for patient safety and successful outcomes of surgical procedures. Informed by the need for quality improvement in patient-anesthesiologist interrelations in a multilingual environment, this study dissects the barriers to effective communication, which confront anesthesiologists in the multilingual environment, as in Nigeria. The study proposes language-based techniques as the panacea for linguistic diversity, solecism, complex medical diction, and cultural and other barriers. The proposal is rooted in the Plan-Do-Study-Act framework. It concludes that where barriers to effective communication are duly addressed, improved patient-anesthesiologist communication, ethical professionalism, efficient performance and timely quality service delivery would obtain.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":" 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141371704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-06DOI: 10.9734/jammr/2024/v36i65468
Camila Pimenta de Araújo Guimarães, Adriana da Silva Torres, Emanuelle Melquiades Barbosa de Oliveira, Júlia Fehrenbach, C. Isolan, Cíntia Tereza Pimenta de Araújo
Aims: The aim of this systematic review was to evaluate the optical properties of monochromatic composite resins and conventional composite resins in direct restorations in permanent teeth. Study Design: A systematic review and meta-analysis. Methodology: The searches were carried out in July and August, in the following databases:: Medline (PubMed), Web of Science, ScienceDirect and Google Scholar. The articles were selected, first by title, followed by reading the abstract and finally the complete work. Two independent meta-analyses were performed using Review Manager 5.4 software. Results: Two hundred and eleven articles were found, 6 articles were included in this systematic review and, among these, 4 were included in the meta-analysis. The meta-analysis when comparing monochromatic resins and conventional composite resins, using color stability data showed greater optical performance of the monochromatic resin for subgroups A2 and A3. After analyzing the age data according to the Coffee and Tea subgroups, the monochromatic resin showed no statistical difference. For color variation during bleaching, the monochromatic resin showed statistically lower color variation. For color matching, conventional resins showed higher shade matching ability compared to monochromatic composite. Conclusion: Therefore, the monochromatic resin presented greater color stability in shades A2 and A3 and presented better results in terms of color variation compared to the conventional composite resin after bleaching.
{"title":"The Chameleon Effect of Monochromatic Composite Resin: A Systematic Review and Meta-Analysis","authors":"Camila Pimenta de Araújo Guimarães, Adriana da Silva Torres, Emanuelle Melquiades Barbosa de Oliveira, Júlia Fehrenbach, C. Isolan, Cíntia Tereza Pimenta de Araújo","doi":"10.9734/jammr/2024/v36i65468","DOIUrl":"https://doi.org/10.9734/jammr/2024/v36i65468","url":null,"abstract":"Aims: The aim of this systematic review was to evaluate the optical properties of monochromatic composite resins and conventional composite resins in direct restorations in permanent teeth. \u0000Study Design: A systematic review and meta-analysis. \u0000Methodology: The searches were carried out in July and August, in the following databases:: Medline (PubMed), Web of Science, ScienceDirect and Google Scholar. The articles were selected, first by title, followed by reading the abstract and finally the complete work. Two independent meta-analyses were performed using Review Manager 5.4 software. \u0000Results: Two hundred and eleven articles were found, 6 articles were included in this systematic review and, among these, 4 were included in the meta-analysis. The meta-analysis when comparing monochromatic resins and conventional composite resins, using color stability data showed greater optical performance of the monochromatic resin for subgroups A2 and A3. After analyzing the age data according to the Coffee and Tea subgroups, the monochromatic resin showed no statistical difference. For color variation during bleaching, the monochromatic resin showed statistically lower color variation. For color matching, conventional resins showed higher shade matching ability compared to monochromatic composite. \u0000Conclusion: Therefore, the monochromatic resin presented greater color stability in shades A2 and A3 and presented better results in terms of color variation compared to the conventional composite resin after bleaching.","PeriodicalId":14869,"journal":{"name":"Journal of Advances in Medicine and Medical Research","volume":"8 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141378521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：