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Unmasking human T cell receptor germline diversity: 335 novel alleles identified in 47 Pangenome reference individuals using the gAIRR Suite 揭示人类T细胞受体种系多样性:使用gAIRR套件在47个泛基因组参考个体中鉴定出335个新的等位基因
IF 10.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-30 DOI: 10.1016/j.jare.2026.01.053
Yu-Hsuan Yang, Chi-Yuan Yao, Mao-Jan Lin, Kuan-Ta Huang, Yu-Hui Lin, Yi-Hui Huang, I-Hsuan Chiu, Sheng-Kai Lai, Chih-Yeh Chen, Ya-Chien Yang, Chia-Lang Hsu, Jacob Shujui Hsu, Chien-Yu Chen, Pei-Lung Chen
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引用次数: 0
Asprosin-driven metabolic-epigenetic rewiring attenuates mesenchymal stem cell senescence with therapeutic benefits for infarcted hearts 阿斯桃素驱动的代谢-表观遗传重布线减轻间充质干细胞衰老,对梗死心脏有治疗益处
IF 10.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-30 DOI: 10.1016/j.jare.2026.01.073
Zhengbin Zhang, Ziqian Wang, Liwen Zhu, Tong Chen, Rundu Chen, Zhengfeng Wu, Jie Chen, Honghong Zhang, Mingyi Wang, Jie Liu, Ning Hua, Shunying Hu, Yundai Chen
{"title":"Asprosin-driven metabolic-epigenetic rewiring attenuates mesenchymal stem cell senescence with therapeutic benefits for infarcted hearts","authors":"Zhengbin Zhang, Ziqian Wang, Liwen Zhu, Tong Chen, Rundu Chen, Zhengfeng Wu, Jie Chen, Honghong Zhang, Mingyi Wang, Jie Liu, Ning Hua, Shunying Hu, Yundai Chen","doi":"10.1016/j.jare.2026.01.073","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.073","url":null,"abstract":"","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"5 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skin regeneration axis under metal-based nanozymes: from chronic wound healing to structural and functional restoration 金属基纳米酶的皮肤再生轴:从慢性伤口愈合到结构和功能修复
IF 10.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-30 DOI: 10.1016/j.jare.2026.01.068
Ze-Ming Zhuang, Kai Guo, Zhang-Rui Wu, Yi Wang, Xin-Cao Zhong, Chun-Ye Chen, Zi-Xuan Feng, Yan-Ze Yu, Hai-Qi Zhang, Min-Hong Tan, Tao Zhang, Xiao-Ying Lin, Yong Wang, Wei-Qiang Tan
{"title":"Skin regeneration axis under metal-based nanozymes: from chronic wound healing to structural and functional restoration","authors":"Ze-Ming Zhuang, Kai Guo, Zhang-Rui Wu, Yi Wang, Xin-Cao Zhong, Chun-Ye Chen, Zi-Xuan Feng, Yan-Ze Yu, Hai-Qi Zhang, Min-Hong Tan, Tao Zhang, Xiao-Ying Lin, Yong Wang, Wei-Qiang Tan","doi":"10.1016/j.jare.2026.01.068","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.068","url":null,"abstract":"","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"143 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cellular and molecular mechanisms of nasolacrimal duct obstruction: New insights into CD4+ T cell-MIF-fibroblast pathways 鼻泪管阻塞的细胞和分子机制:对CD4+ T细胞- mif -成纤维细胞通路的新认识
IF 10.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-28 DOI: 10.1016/j.jare.2026.01.060
Xinyue Yu, Shanshan Liu, Youao Zhang, Rongxin Chen, Chaojuan Wen, Jingya Zhu, Xielan Kuang, Kerui Wang, Hao Huang, Yan Mao, Ping Xu, Jianhua Yan, Qingjiong Zhang, Xuanwei Liang, Huangxuan Shen
{"title":"Cellular and molecular mechanisms of nasolacrimal duct obstruction: New insights into CD4+ T cell-MIF-fibroblast pathways","authors":"Xinyue Yu, Shanshan Liu, Youao Zhang, Rongxin Chen, Chaojuan Wen, Jingya Zhu, Xielan Kuang, Kerui Wang, Hao Huang, Yan Mao, Ping Xu, Jianhua Yan, Qingjiong Zhang, Xuanwei Liang, Huangxuan Shen","doi":"10.1016/j.jare.2026.01.060","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.060","url":null,"abstract":"","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"31 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An injectable microsphere-reinforced system for sustained delivery of Adipo-MBV in adipose tissue engineering 脂肪组织工程中用于持续递送Adipo-MBV的可注射微球增强系统
IF 10.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-27 DOI: 10.1016/j.jare.2026.01.058
Mmi Xu, Jianwei Chen, Yi Sun, Han Yang, Hongli Ji, Tao Xu, Feng Lu, Yunfan He
Tissue engineering has become prominence in soft-tissue reconstruction. Adipogenesis and angiogenesis are important in the formation of engineering adipose tissue. Although acellular adipose matrix (AAM) possesses potential in adipogenic induction, obvious limitations remain in the realization of the authentic physiological regeneration. Matrix-bound nanovesicles (MBVs), located on the extracellular matrix (ECM) scaffold, provide cues for the adipogenesis property of AAM. The bioactive components within ECM are influenced by the isolation procedures.
组织工程已成为软组织重建的重点。脂肪生成和血管生成是工程脂肪组织形成的重要过程。虽然脱细胞脂肪基质(AAM)具有诱导脂肪生成的潜力,但在实现真正的生理再生方面仍存在明显的局限性。位于细胞外基质(ECM)支架上的基质结合纳米囊泡(mbv)为AAM的脂肪形成特性提供了线索。ECM中的生物活性成分受分离过程的影响。
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引用次数: 0
Optimizing water allocation in irrigation districts for enhanced sustainability and climate resilience 优化灌区水资源配置,提高可持续性和气候适应能力
IF 10.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-27 DOI: 10.1016/j.jare.2026.01.055
Yingshan Chen, Mo Li, Qiang Fu, Xiao Liu, Lei Yu, Vijay P. Singh, Luchen Wang
Irrigation plays a crucial role in enhancing agricultural productivity. However, it simultaneously increases water consumption and greenhouse gas (GHG) emissions, a challenge that is further exacerbated by climate change. While many irrigation strategies have been proposed, their potential to balance crop yield growth, water productivity improvement and carbon emission reduction in large-scale irrigation districts remains unclear.
灌溉在提高农业生产力方面起着至关重要的作用。然而,它同时增加了水消耗和温室气体(GHG)排放,这一挑战因气候变化而进一步加剧。虽然已经提出了许多灌溉策略,但它们在大规模灌区平衡作物产量增长、提高水生产力和减少碳排放方面的潜力尚不清楚。
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引用次数: 0
Comparative genomics reveals two major lineages of Bifidobacterium adolescentis in the human gut, driven by divergent adaptation in China and the United States 比较基因组学揭示了人类肠道中青少年双歧杆菌的两个主要谱系,这是由中国和美国的不同适应驱动的
IF 10.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-26 DOI: 10.1016/j.jare.2026.01.071
Linbo Shi, Meng Zhang, Ruonan Zheng, Lai-Yu Kwok, Wenyi Zhang
Bifidobacterium adolescentis is a key beneficial member of the human gut microbiota, but its genomic diversity and evolutionary drivers across human populations remain poorly characterized.
青少年双歧杆菌是人类肠道微生物群的关键有益成员,但其基因组多样性和进化驱动因素在人类群体中的特征仍然很差。
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引用次数: 0
Selectively targeting UDP-glucose 4-epimerase MoUGE1 for controlling rice blast disease 选择性靶向UDP-glucose 4-epimerase MoUGE1防治稻瘟病
IF 10.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-26 DOI: 10.1016/j.jare.2026.01.072
Zhiguang Qu, Deng Chen, Hong Hu, Hao Liu, Lu Zheng, Junbin Huang, Yunfeng Li, Lida Zhu, Xiaolin Chen
The fungal cell wall, a dynamic structure critical for pathogenesis, is composed of polysaccharides and proteins. UDP-glucose 4-epimerases (UGEs) play a pivotal role in cell wall synthesis by converting UDP-galactose between UDP-glucose. This study investigates the role of MoUGE1 in Magnaporthe oryzae pathogenesis and explores its potential as an antifungal target for fungal disease control. A lead inhibitor targeting MoUGE1 was identified through virtual screening.
真菌细胞壁是一种由多糖和蛋白质组成的动态结构,对真菌的发病至关重要。UDP-glucose 4- epimease (UGEs)通过在UDP-glucose之间转换udp -半乳糖,在细胞壁合成中起关键作用。本研究探讨了MoUGE1在水稻Magnaporthe oryzae发病机制中的作用,并探讨了其作为真菌疾病控制的抗真菌靶点的潜力。通过虚拟筛选确定了一种靶向MoUGE1的先导抑制剂。
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引用次数: 0
Molecular choreography of vesicle trafficking: Exocyst–SNARE interplay in plant defense 囊泡运输的分子编舞:囊泡-陷阱在植物防御中的相互作用
IF 10.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-26 DOI: 10.1016/j.jare.2026.01.059
Muhammad Adnan, Liu Xiaokun
The plant secretory system operates as a precision logistics network that sustains cellular homeostasis and mobilizes rapid defense against pathogens. Central to this system are SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins, which catalyze membrane fusion, and the octameric exocyst complex, which tethers trans-Golgi–derived vesicles to defined plasma-membrane domains. Rather than functioning independently, these machineries act as an interdependent module: the exocyst facilitates vesicle tethering and promotes SNARE complex assembly, while SNARE proteins reciprocally stabilize exocyst positioning and activity. This synergy ensures the targeted delivery of immune cargos—including pathogenesis-related proteins, callose synthases, transporters, and specialized metabolites—directly to pathogen attack sites. However, pathogens deploy effectors that disrupt exocyst–SNARE interfaces, weakening these defensive supply lines.
植物分泌系统作为一个精确的物流网络运作,维持细胞稳态并动员对病原体的快速防御。该系统的核心是催化膜融合的SNARE(可溶性n -乙基马来酰亚胺敏感因子附着蛋白受体)蛋白,以及将反式高尔基衍生囊泡连接到确定的质膜结构域的八聚体外囊复合物。这些机制不是独立运作,而是作为一个相互依赖的模块:囊泡促进囊泡系结并促进SNARE复合物的组装,而SNARE蛋白则相互稳定囊泡的定位和活性。这种协同作用确保了免疫货物(包括致病相关蛋白、胼胝质合成酶、转运蛋白和专门的代谢物)直接靶向递送到病原体攻击部位。然而,病原体部署效应物破坏囊胞-陷阱界面,削弱这些防御供应线。
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引用次数: 0
Mitocytosis, mitophagy, and apoptosis coordinately drive mitochondrial clearance to regulate myogenic differentiation 有丝分裂、有丝自噬和细胞凋亡协同驱动线粒体清除以调节肌源性分化
IF 10.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-01-26 DOI: 10.1016/j.jare.2026.01.065
Dandan Wang, Mei Li, Jun Ma, Guocheng Du, Jingwen Zhou, Jian Chen, Xin Guan
Skeletal muscle is a high-energy-consuming tissue whose development and function critically depend on mitochondrial homeostasis. Mitochondrial quality control involves multiple clearance mechanisms, including mitocytosis, mitophagy, and apoptosis. However, how these pathways are coordinated during myogenic differentiation remains systematically unexplained.
骨骼肌是一种高能量消耗组织,其发育和功能严重依赖于线粒体稳态。线粒体质量控制涉及多种清除机制,包括有丝分裂、有丝分裂和细胞凋亡。然而,这些途径在肌源性分化过程中是如何协调的,仍然没有系统地解释。
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引用次数: 0
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