Pub Date : 2026-01-27DOI: 10.1016/j.jare.2026.01.058
Mmi Xu, Jianwei Chen, Yi Sun, Han Yang, Hongli Ji, Tao Xu, Feng Lu, Yunfan He
Tissue engineering has become prominence in soft-tissue reconstruction. Adipogenesis and angiogenesis are important in the formation of engineering adipose tissue. Although acellular adipose matrix (AAM) possesses potential in adipogenic induction, obvious limitations remain in the realization of the authentic physiological regeneration. Matrix-bound nanovesicles (MBVs), located on the extracellular matrix (ECM) scaffold, provide cues for the adipogenesis property of AAM. The bioactive components within ECM are influenced by the isolation procedures.
{"title":"An injectable microsphere-reinforced system for sustained delivery of Adipo-MBV in adipose tissue engineering","authors":"Mmi Xu, Jianwei Chen, Yi Sun, Han Yang, Hongli Ji, Tao Xu, Feng Lu, Yunfan He","doi":"10.1016/j.jare.2026.01.058","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.058","url":null,"abstract":"Tissue engineering has become prominence in soft-tissue reconstruction. Adipogenesis and angiogenesis are important in the formation of engineering adipose tissue. Although acellular adipose matrix (AAM) possesses potential in adipogenic induction, obvious limitations remain in the realization of the authentic physiological regeneration. Matrix-bound nanovesicles (MBVs), located on the extracellular matrix (ECM) scaffold, provide cues for the adipogenesis property of AAM. The bioactive components within ECM are influenced by the isolation procedures.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"28 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1016/j.jare.2026.01.055
Yingshan Chen, Mo Li, Qiang Fu, Xiao Liu, Lei Yu, Vijay P. Singh, Luchen Wang
Irrigation plays a crucial role in enhancing agricultural productivity. However, it simultaneously increases water consumption and greenhouse gas (GHG) emissions, a challenge that is further exacerbated by climate change. While many irrigation strategies have been proposed, their potential to balance crop yield growth, water productivity improvement and carbon emission reduction in large-scale irrigation districts remains unclear.
{"title":"Optimizing water allocation in irrigation districts for enhanced sustainability and climate resilience","authors":"Yingshan Chen, Mo Li, Qiang Fu, Xiao Liu, Lei Yu, Vijay P. Singh, Luchen Wang","doi":"10.1016/j.jare.2026.01.055","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.055","url":null,"abstract":"Irrigation plays a crucial role in enhancing agricultural productivity. However, it simultaneously increases water consumption and greenhouse gas (GHG) emissions, a challenge that is further exacerbated by climate change. While many irrigation strategies have been proposed, their potential to balance crop yield growth, water productivity improvement and carbon emission reduction in large-scale irrigation districts remains unclear.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"53 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bifidobacterium adolescentis is a key beneficial member of the human gut microbiota, but its genomic diversity and evolutionary drivers across human populations remain poorly characterized.
{"title":"Comparative genomics reveals two major lineages of Bifidobacterium adolescentis in the human gut, driven by divergent adaptation in China and the United States","authors":"Linbo Shi, Meng Zhang, Ruonan Zheng, Lai-Yu Kwok, Wenyi Zhang","doi":"10.1016/j.jare.2026.01.071","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.071","url":null,"abstract":"<ce:italic>Bifidobacterium adolescentis</ce:italic> is a key beneficial member of the human gut microbiota, but its genomic diversity and evolutionary drivers across human populations remain poorly characterized.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"291 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-26DOI: 10.1016/j.jare.2026.01.072
Zhiguang Qu, Deng Chen, Hong Hu, Hao Liu, Lu Zheng, Junbin Huang, Yunfeng Li, Lida Zhu, Xiaolin Chen
The fungal cell wall, a dynamic structure critical for pathogenesis, is composed of polysaccharides and proteins. UDP-glucose 4-epimerases (UGEs) play a pivotal role in cell wall synthesis by converting UDP-galactose between UDP-glucose. This study investigates the role of MoUGE1 in Magnaporthe oryzae pathogenesis and explores its potential as an antifungal target for fungal disease control. A lead inhibitor targeting MoUGE1 was identified through virtual screening.
{"title":"Selectively targeting UDP-glucose 4-epimerase MoUGE1 for controlling rice blast disease","authors":"Zhiguang Qu, Deng Chen, Hong Hu, Hao Liu, Lu Zheng, Junbin Huang, Yunfeng Li, Lida Zhu, Xiaolin Chen","doi":"10.1016/j.jare.2026.01.072","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.072","url":null,"abstract":"The fungal cell wall, a dynamic structure critical for pathogenesis, is composed of polysaccharides and proteins. UDP-glucose 4-epimerases (UGEs) play a pivotal role in cell wall synthesis by converting UDP-galactose between UDP-glucose. This study investigates the role of MoUGE1 in <ce:italic>Magnaporthe oryzae</ce:italic> pathogenesis and explores its potential as an antifungal target for fungal disease control. A lead inhibitor targeting MoUGE1 was identified through virtual screening.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"7 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-26DOI: 10.1016/j.jare.2026.01.059
Muhammad Adnan, Liu Xiaokun
The plant secretory system operates as a precision logistics network that sustains cellular homeostasis and mobilizes rapid defense against pathogens. Central to this system are SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins, which catalyze membrane fusion, and the octameric exocyst complex, which tethers trans-Golgi–derived vesicles to defined plasma-membrane domains. Rather than functioning independently, these machineries act as an interdependent module: the exocyst facilitates vesicle tethering and promotes SNARE complex assembly, while SNARE proteins reciprocally stabilize exocyst positioning and activity. This synergy ensures the targeted delivery of immune cargos—including pathogenesis-related proteins, callose synthases, transporters, and specialized metabolites—directly to pathogen attack sites. However, pathogens deploy effectors that disrupt exocyst–SNARE interfaces, weakening these defensive supply lines.
{"title":"Molecular choreography of vesicle trafficking: Exocyst–SNARE interplay in plant defense","authors":"Muhammad Adnan, Liu Xiaokun","doi":"10.1016/j.jare.2026.01.059","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.059","url":null,"abstract":"The plant secretory system operates as a precision logistics network that sustains cellular homeostasis and mobilizes rapid defense against pathogens. Central to this system are SNARE (soluble <ce:italic>N</ce:italic>-ethylmaleimide-sensitive factor attachment protein receptor) proteins, which catalyze membrane fusion, and the octameric exocyst complex, which tethers <ce:italic>trans</ce:italic>-Golgi–derived vesicles to defined plasma-membrane domains. Rather than functioning independently, these machineries act as an interdependent module: the exocyst facilitates vesicle tethering and promotes SNARE complex assembly, while SNARE proteins reciprocally stabilize exocyst positioning and activity. This synergy ensures the targeted delivery of immune cargos—including pathogenesis-related proteins, callose synthases, transporters, and specialized metabolites—directly to pathogen attack sites. However, pathogens deploy effectors that disrupt exocyst–SNARE interfaces, weakening these defensive supply lines.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"1 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-26DOI: 10.1016/j.jare.2026.01.065
Dandan Wang, Mei Li, Jun Ma, Guocheng Du, Jingwen Zhou, Jian Chen, Xin Guan
Skeletal muscle is a high-energy-consuming tissue whose development and function critically depend on mitochondrial homeostasis. Mitochondrial quality control involves multiple clearance mechanisms, including mitocytosis, mitophagy, and apoptosis. However, how these pathways are coordinated during myogenic differentiation remains systematically unexplained.
{"title":"Mitocytosis, mitophagy, and apoptosis coordinately drive mitochondrial clearance to regulate myogenic differentiation","authors":"Dandan Wang, Mei Li, Jun Ma, Guocheng Du, Jingwen Zhou, Jian Chen, Xin Guan","doi":"10.1016/j.jare.2026.01.065","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.065","url":null,"abstract":"Skeletal muscle is a high-energy-consuming tissue whose development and function critically depend on mitochondrial homeostasis. Mitochondrial quality control involves multiple clearance mechanisms, including mitocytosis, mitophagy, and apoptosis. However, how these pathways are coordinated during myogenic differentiation remains systematically unexplained.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"1 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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