Pub Date : 2026-01-25DOI: 10.1016/j.jare.2026.01.061
Yiming Wang, Qiao Gao, Lian Shan, Wenyi Cao, Yuanxun Li, Wenbing Ding, Hongshuai Gao, Jin Xue, Hualiang He, Lin Qiu, Youzhi Li
The infection of plant viruses alters the wing dimorphism and reproductive development of vector insects, thereby enhancing viral dissemination. Notably, a fundamental trade-off inherently exists between wing development and reproductive development in insects. However, the regulatory mechanisms through which plant viruses balance these developmental processes remain poorly characterized. Elucidating such mechanisms is crucial for understanding viral transmission strategies.
{"title":"A plant virus-derived siRNA modulates wing dimorphism and fertility of vector insects to enhance virus spread","authors":"Yiming Wang, Qiao Gao, Lian Shan, Wenyi Cao, Yuanxun Li, Wenbing Ding, Hongshuai Gao, Jin Xue, Hualiang He, Lin Qiu, Youzhi Li","doi":"10.1016/j.jare.2026.01.061","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.061","url":null,"abstract":"The infection of plant viruses alters the wing dimorphism and reproductive development of vector insects, thereby enhancing viral dissemination. Notably, a fundamental trade-off inherently exists between wing development and reproductive development in insects. However, the regulatory mechanisms through which plant viruses balance these developmental processes remain poorly characterized. Elucidating such mechanisms is crucial for understanding viral transmission strategies.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"22 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Low back pain (LBP) is a prevalent cause of disability worldwide. A crucial mechanism underlying LBP is that senescent-like macrophages induce endplate sclerosis by coupling angiogenesis-osteogenesis through IL-10. Then, the osteoclasts attract sensory innervation to perceive pain during endplate sclerosis. Therefore, targeted clearance of senescent-like macrophages is expected to be a new direction for LBP treatment.
{"title":"Targeted delivery of senolytic drugs using macrophage membrane-camouflaged magnetic nanoparticles inhibits endplate sclerosis","authors":"Weiping Su, Chenhao Shi, Yixiao Pan, Boyan Ma, Yueke Sun, Mingzhe Fan, Lantian Zhao, Yuanyang Zhu, Xianglong Zhuo, Shiqing Feng, Shuangfei Ni","doi":"10.1016/j.jare.2026.01.054","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.054","url":null,"abstract":"Low back pain (LBP) is a prevalent cause of disability worldwide. A crucial mechanism underlying LBP is that senescent-like macrophages induce endplate sclerosis by coupling angiogenesis-osteogenesis through IL-10. Then, the osteoclasts attract sensory innervation to perceive pain during endplate sclerosis. Therefore, targeted clearance of senescent-like macrophages is expected to be a new direction for LBP treatment.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"14 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-25DOI: 10.1016/j.jare.2026.01.064
Qiongdan Gao, Zhenkun Wang, Yuting Fu, Shuyi Lin, Haiping Liu, Yuanyuan Zhou, Yifei Wei, Zhenyu Ju, Lili Zhou, Bo Liu
Renal fibrosis is a common pathological hallmark of chronic kidney disease (CKD), and ultimately leads to end-stage renal disease. ER-stress and TGF-β signaling pathway activation play critical roles in renal fibrosis, but the precise mechanisms underlying the intricate interplay between ER-stress and TGF-β signaling pathway remain ambiguous. Our previous study has demonstrated that EVA1A responds to ER-stress to regulate hematopoietic stem cell regeneration; However, the function of EVA1A in renal fibrosis remains unexplored.
{"title":"EVA1A responds to endoplasmic reticulum stress to regulate renal fibrosis by promoting TGF-β signaling pathway","authors":"Qiongdan Gao, Zhenkun Wang, Yuting Fu, Shuyi Lin, Haiping Liu, Yuanyuan Zhou, Yifei Wei, Zhenyu Ju, Lili Zhou, Bo Liu","doi":"10.1016/j.jare.2026.01.064","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.064","url":null,"abstract":"Renal fibrosis is a common pathological hallmark of chronic kidney disease (CKD), and ultimately leads to end-stage renal disease. ER-stress and TGF-β signaling pathway activation play critical roles in renal fibrosis, but the precise mechanisms underlying the intricate interplay between ER-stress and TGF-β signaling pathway remain ambiguous. Our previous study has demonstrated that EVA1A responds to ER-stress to regulate hematopoietic stem cell regeneration; However, the function of EVA1A in renal fibrosis remains unexplored.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"85 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-24DOI: 10.1016/j.jare.2026.01.026
Yihong Ding, Zhaoping Wang, Jiabei He, Jie Shen, Changzheng Yuan, Di He, Yimin Zhu
Frailty changes over time, but how these changes relate to the risk of dementia remains uncertain.
随着时间的推移，虚弱会发生变化，但这些变化与患痴呆症的风险之间的关系仍不确定。
{"title":"Longitudinal dynamics in frailty and incident all-cause dementia: a multicohort study","authors":"Yihong Ding, Zhaoping Wang, Jiabei He, Jie Shen, Changzheng Yuan, Di He, Yimin Zhu","doi":"10.1016/j.jare.2026.01.026","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.026","url":null,"abstract":"Frailty changes over time, but how these changes relate to the risk of dementia remains uncertain.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"53 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1016/j.jare.2026.01.043
Feipeng Cui, Mengfan Wang, Linxi Tang, Yudiyang Ma, Jianing Wang, Lei Zheng, Meiqi Xing, Junqing Xie, Lin Han, Yaohua Tian
{"title":"Residential greenness, air pollution, and epilepsy: Insight in genetic susceptibility and life expectancy","authors":"Feipeng Cui, Mengfan Wang, Linxi Tang, Yudiyang Ma, Jianing Wang, Lei Zheng, Meiqi Xing, Junqing Xie, Lin Han, Yaohua Tian","doi":"10.1016/j.jare.2026.01.043","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.043","url":null,"abstract":"","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"117 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146033652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1016/j.jare.2026.01.030
Yimei Zheng, Boyu Chen, Xuanxiang Huang, Chao Ai, Hui Teng, Lei Chen
{"title":"Boosting luteolin bioavailability via P-glycoprotein efflux inhibition: a self-microemulsifying drug delivery systems","authors":"Yimei Zheng, Boyu Chen, Xuanxiang Huang, Chao Ai, Hui Teng, Lei Chen","doi":"10.1016/j.jare.2026.01.030","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.030","url":null,"abstract":"","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"62 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146015050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.1016/j.jare.2026.01.051
Marta Chierichetti, Roberta Andreotti, Barbara Tedesco, Veronica Ferrari, Laura Cornaggia, Paola Pramaggiore, Marta Cozzi, Ali Mohamed, Rocio Magdalena, Margherita Piccolella, Giulia Boarolo, Valeria Crippa, Paola Rusmini, Mariarita Galbiati, Carlo Rinaldi, Eric N. Anderson, Udai Bhan Pandey, Maria Pennuto, Riccardo Cristofani, Angelo Poletti
Introduction
Spinal and bulbar muscular atrophy (SBMA) is an X-linked neuromuscular disease caused by a CAG-repeat expansion in the androgen receptor (AR) gene,translated into an elongated polyglutamine (polyQ) tract in the protein. Androgens trigger ARpolyQ toxicity, thus most potential therapeutic approaches involve androgen reduction or AR negative modulation, with severe endocrine side effects.
Objective
A start codon (I-AUGs) controls AR translation, while a second one, (II-AUG) downstream to I-AUG and the CAG repeat, drives translation of the shorter AR isoform (AR-A) lacking the polyQ tract, but preserves all relevant AR functional domains. Here, we studied AR-A behaviour and its effect on ARpolyQ toxicity in SBMA.
Methods
We took advantage of both cellular and Drosophila melanogaster SBMA models to asses AR-A behaviour and effect on ARpolyQ aggregation and functions.
Results
Comparative expression analyses of AR isoforms revealed that AR-A is predominantly located in the mouse brainstem and spinal cord of the central nervous system, but not in muscle. AR-A retains partial androgenic activity, but does not aggregate. Since ARpolyQ and AR-A can heterodimerize, we tested the effect of AR-A on ARpolyQ behaviour, showing that AR-A has a pro-solubilizing effect on ARpolyQ aggregates and that the heterodimers retain the transcriptional activity. Finally, we tested the effect of AR-A in a fly model of SBMA. Flies expressing AR-A alone showed no signs of external eye degeneration, in contrast to those expressing expanded ARpolyQ. Notably, co-expression of AR-A with ARpolyQ significantly reduced ARpolyQ aggregation and eye degeneration, supporting our hypothesis that AR-A enhances ARpolyQ solubility and mitigates its toxicity in vivo.
Conclusions
Altogether, our results demonstrate that an increased expression of AR-A may have a role in protecting against ARpolyQ aggregation and toxicity. These findings suggest that AR-A could represent a promising avenue for developing an alternative therapeutic strategy that warrants further investigation.
{"title":"The alternative androgen receptor isoform a mitigates toxicity of polyglutamine-elongated mutant androgen receptor in spinal and bulbar muscular atrophy","authors":"Marta Chierichetti, Roberta Andreotti, Barbara Tedesco, Veronica Ferrari, Laura Cornaggia, Paola Pramaggiore, Marta Cozzi, Ali Mohamed, Rocio Magdalena, Margherita Piccolella, Giulia Boarolo, Valeria Crippa, Paola Rusmini, Mariarita Galbiati, Carlo Rinaldi, Eric N. Anderson, Udai Bhan Pandey, Maria Pennuto, Riccardo Cristofani, Angelo Poletti","doi":"10.1016/j.jare.2026.01.051","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.051","url":null,"abstract":"<h3>Introduction</h3>Spinal and bulbar muscular atrophy (SBMA) is an X-linked neuromuscular disease caused by a CAG-repeat expansion in the androgen receptor (AR) gene,translated into an elongated polyglutamine (polyQ) tract in the protein. Androgens trigger ARpolyQ toxicity, thus most potential therapeutic approaches involve androgen reduction or AR negative modulation, with severe endocrine side effects.<h3>Objective</h3>A start codon (I-AUGs) controls AR translation, while a second one, (II-AUG) downstream to I-AUG and the CAG repeat, drives translation of the shorter AR isoform (AR-A) lacking the polyQ tract, but preserves all relevant AR functional domains. Here, we studied AR-A behaviour and its effect on ARpolyQ toxicity in SBMA.<h3>Methods</h3>We took advantage of both cellular and Drosophila melanogaster SBMA models to asses AR-A behaviour and effect on ARpolyQ aggregation and functions.<h3>Results</h3>Comparative expression analyses of AR isoforms revealed that AR-A is predominantly located in the mouse brainstem and spinal cord of the central nervous system, but not in muscle. AR-A retains partial androgenic activity, but does not aggregate. Since ARpolyQ and AR-A can heterodimerize, we tested the effect of AR-A on ARpolyQ behaviour, showing that AR-A has a pro-solubilizing effect on ARpolyQ aggregates and that the heterodimers retain the transcriptional activity. Finally, we tested the effect of AR-A in a fly model of SBMA. Flies expressing AR-A alone showed no signs of external eye degeneration, in contrast to those expressing expanded ARpolyQ. Notably, co-expression of AR-A with ARpolyQ significantly reduced ARpolyQ aggregation and eye degeneration, supporting our hypothesis that AR-A enhances ARpolyQ solubility and mitigates its toxicity <em>in vivo</em>.<h3>Conclusions</h3>Altogether, our results demonstrate that an increased expression of AR-A may have a role in protecting against ARpolyQ aggregation and toxicity. These findings suggest that AR-A could represent a promising avenue for developing an alternative therapeutic strategy that warrants further investigation.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"383 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.1016/j.jare.2026.01.052
Aleksandra Wilk, Natalia Wilkosz, Marzena Rugiel, Marta Saluga, Kamil Kawon, Tetiana Stepanenko, Katarzyna Bulat, Aleksandra Wajda, Michał Szuwarzynski, Anna Zajaczkowska, Anna Morgunowicz, Grzegorz Chodaczek, Víctor Navarro-Esteve, David Perez-Guaita, Joanna Chwiej, Katarzyna M. Marzec
{"title":"Next-generation diabetes diagnostics: spectrochemical staging of red blood cells using vibrational spectroscopy","authors":"Aleksandra Wilk, Natalia Wilkosz, Marzena Rugiel, Marta Saluga, Kamil Kawon, Tetiana Stepanenko, Katarzyna Bulat, Aleksandra Wajda, Michał Szuwarzynski, Anna Zajaczkowska, Anna Morgunowicz, Grzegorz Chodaczek, Víctor Navarro-Esteve, David Perez-Guaita, Joanna Chwiej, Katarzyna M. Marzec","doi":"10.1016/j.jare.2026.01.052","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.052","url":null,"abstract":"","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"54 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146015056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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