Pub Date : 2026-01-27DOI: 10.1016/j.jare.2026.01.055
Yingshan Chen, Mo Li, Qiang Fu, Xiao Liu, Lei Yu, Vijay P. Singh, Luchen Wang
Irrigation plays a crucial role in enhancing agricultural productivity. However, it simultaneously increases water consumption and greenhouse gas (GHG) emissions, a challenge that is further exacerbated by climate change. While many irrigation strategies have been proposed, their potential to balance crop yield growth, water productivity improvement and carbon emission reduction in large-scale irrigation districts remains unclear.
{"title":"Optimizing water allocation in irrigation districts for enhanced sustainability and climate resilience","authors":"Yingshan Chen, Mo Li, Qiang Fu, Xiao Liu, Lei Yu, Vijay P. Singh, Luchen Wang","doi":"10.1016/j.jare.2026.01.055","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.055","url":null,"abstract":"Irrigation plays a crucial role in enhancing agricultural productivity. However, it simultaneously increases water consumption and greenhouse gas (GHG) emissions, a challenge that is further exacerbated by climate change. While many irrigation strategies have been proposed, their potential to balance crop yield growth, water productivity improvement and carbon emission reduction in large-scale irrigation districts remains unclear.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"53 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bifidobacterium adolescentis is a key beneficial member of the human gut microbiota, but its genomic diversity and evolutionary drivers across human populations remain poorly characterized.
{"title":"Comparative genomics reveals two major lineages of Bifidobacterium adolescentis in the human gut, driven by divergent adaptation in China and the United States","authors":"Linbo Shi, Meng Zhang, Ruonan Zheng, Lai-Yu Kwok, Wenyi Zhang","doi":"10.1016/j.jare.2026.01.071","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.071","url":null,"abstract":"<ce:italic>Bifidobacterium adolescentis</ce:italic> is a key beneficial member of the human gut microbiota, but its genomic diversity and evolutionary drivers across human populations remain poorly characterized.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"291 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-26DOI: 10.1016/j.jare.2026.01.072
Zhiguang Qu, Deng Chen, Hong Hu, Hao Liu, Lu Zheng, Junbin Huang, Yunfeng Li, Lida Zhu, Xiaolin Chen
The fungal cell wall, a dynamic structure critical for pathogenesis, is composed of polysaccharides and proteins. UDP-glucose 4-epimerases (UGEs) play a pivotal role in cell wall synthesis by converting UDP-galactose between UDP-glucose. This study investigates the role of MoUGE1 in Magnaporthe oryzae pathogenesis and explores its potential as an antifungal target for fungal disease control. A lead inhibitor targeting MoUGE1 was identified through virtual screening.
{"title":"Selectively targeting UDP-glucose 4-epimerase MoUGE1 for controlling rice blast disease","authors":"Zhiguang Qu, Deng Chen, Hong Hu, Hao Liu, Lu Zheng, Junbin Huang, Yunfeng Li, Lida Zhu, Xiaolin Chen","doi":"10.1016/j.jare.2026.01.072","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.072","url":null,"abstract":"The fungal cell wall, a dynamic structure critical for pathogenesis, is composed of polysaccharides and proteins. UDP-glucose 4-epimerases (UGEs) play a pivotal role in cell wall synthesis by converting UDP-galactose between UDP-glucose. This study investigates the role of MoUGE1 in <ce:italic>Magnaporthe oryzae</ce:italic> pathogenesis and explores its potential as an antifungal target for fungal disease control. A lead inhibitor targeting MoUGE1 was identified through virtual screening.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"7 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-26DOI: 10.1016/j.jare.2026.01.059
Muhammad Adnan, Liu Xiaokun
The plant secretory system operates as a precision logistics network that sustains cellular homeostasis and mobilizes rapid defense against pathogens. Central to this system are SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins, which catalyze membrane fusion, and the octameric exocyst complex, which tethers trans-Golgi–derived vesicles to defined plasma-membrane domains. Rather than functioning independently, these machineries act as an interdependent module: the exocyst facilitates vesicle tethering and promotes SNARE complex assembly, while SNARE proteins reciprocally stabilize exocyst positioning and activity. This synergy ensures the targeted delivery of immune cargos—including pathogenesis-related proteins, callose synthases, transporters, and specialized metabolites—directly to pathogen attack sites. However, pathogens deploy effectors that disrupt exocyst–SNARE interfaces, weakening these defensive supply lines.
{"title":"Molecular choreography of vesicle trafficking: Exocyst–SNARE interplay in plant defense","authors":"Muhammad Adnan, Liu Xiaokun","doi":"10.1016/j.jare.2026.01.059","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.059","url":null,"abstract":"The plant secretory system operates as a precision logistics network that sustains cellular homeostasis and mobilizes rapid defense against pathogens. Central to this system are SNARE (soluble <ce:italic>N</ce:italic>-ethylmaleimide-sensitive factor attachment protein receptor) proteins, which catalyze membrane fusion, and the octameric exocyst complex, which tethers <ce:italic>trans</ce:italic>-Golgi–derived vesicles to defined plasma-membrane domains. Rather than functioning independently, these machineries act as an interdependent module: the exocyst facilitates vesicle tethering and promotes SNARE complex assembly, while SNARE proteins reciprocally stabilize exocyst positioning and activity. This synergy ensures the targeted delivery of immune cargos—including pathogenesis-related proteins, callose synthases, transporters, and specialized metabolites—directly to pathogen attack sites. However, pathogens deploy effectors that disrupt exocyst–SNARE interfaces, weakening these defensive supply lines.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"1 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-26DOI: 10.1016/j.jare.2026.01.065
Dandan Wang, Mei Li, Jun Ma, Guocheng Du, Jingwen Zhou, Jian Chen, Xin Guan
Skeletal muscle is a high-energy-consuming tissue whose development and function critically depend on mitochondrial homeostasis. Mitochondrial quality control involves multiple clearance mechanisms, including mitocytosis, mitophagy, and apoptosis. However, how these pathways are coordinated during myogenic differentiation remains systematically unexplained.
{"title":"Mitocytosis, mitophagy, and apoptosis coordinately drive mitochondrial clearance to regulate myogenic differentiation","authors":"Dandan Wang, Mei Li, Jun Ma, Guocheng Du, Jingwen Zhou, Jian Chen, Xin Guan","doi":"10.1016/j.jare.2026.01.065","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.065","url":null,"abstract":"Skeletal muscle is a high-energy-consuming tissue whose development and function critically depend on mitochondrial homeostasis. Mitochondrial quality control involves multiple clearance mechanisms, including mitocytosis, mitophagy, and apoptosis. However, how these pathways are coordinated during myogenic differentiation remains systematically unexplained.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"1 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Demyelination is associated with behavioral disorder and cognitive impairment in neuropsychiatric diseases, including major depressive disorder (MDD). However, the mechanism underlying myelin damage remains unclear, despite stress maybe a major risk factor.
{"title":"OSBPL6 protects against demyelination and behavioral disorder via promoting cholesterol transport in oligodendrocyte","authors":"Mengni Chang, Kaiqi Zhang, Ye Li, Xiao Chen, Tian Lan, Yan Zhu, Wenjing Wang, Changmin Wang, Xianghua Zhuang, Shihong Chen, Shuyan Yu","doi":"10.1016/j.jare.2026.01.066","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.066","url":null,"abstract":"Demyelination is associated with behavioral disorder and cognitive impairment in neuropsychiatric diseases, including major depressive disorder (MDD). However, the mechanism underlying myelin damage remains unclear, despite stress maybe a major risk factor.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"50 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-26DOI: 10.1016/j.jare.2026.01.063
Xiaoqing Xu, Yang Wang, Qianmin Liu, Yue Li, Shuo Yang, Runyi Zhou, Yina Wang, Xiang Qi, Can Zhang, Fengmin Zhang, Yue Wu, Yuhao Li, Ying Li
Dietary protein has multiple physiological functions. However, high-protein diets have been proven to elevate the risk of all-cause mortality. Aging is a dynamic and complex process, but the impact of dietary protein on aging remains unclear.
{"title":"High-protein diet promotes aging by activating the CG6415/AMT gene and disrupting mitochondrial homeostasis","authors":"Xiaoqing Xu, Yang Wang, Qianmin Liu, Yue Li, Shuo Yang, Runyi Zhou, Yina Wang, Xiang Qi, Can Zhang, Fengmin Zhang, Yue Wu, Yuhao Li, Ying Li","doi":"10.1016/j.jare.2026.01.063","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.063","url":null,"abstract":"Dietary protein has multiple physiological functions. However, high-protein diets have been proven to elevate the risk of all-cause mortality. Aging is a dynamic and complex process, but the impact of dietary protein on aging remains unclear.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"24 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ovarian aging is a significant concern, yet the influencing factors remain unclear. Environmental factors are crucial determinants of diminished ovarian reserve (DOR). Microplastics and nanoplastics (MNPs) are widespread in the environment and pose health risks. The effect of MNPs on ovarian function remains uncertain.
{"title":"Microplastics and nanoplastics in follicular fluid are associated with diminished ovarian reserve: clinical and molecular insights","authors":"Manfei Si, Xianglei Xiong, Chuyu Yun, Yongyan Chen, Hongyu Niu, Yi Qu, Mengyu Liu, Yuqian Wang, Lixuan Huang, Xiaoyu Long, Wei Wang, Rui Yang, Rui Liu, Yanli Pang, Xiumei Zhen, Rong Li, Tian Tian, Xinyu Qi, Jie Qiao","doi":"10.1016/j.jare.2026.01.074","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.074","url":null,"abstract":"Ovarian aging is a significant concern, yet the influencing factors remain unclear. Environmental factors are crucial determinants of diminished ovarian reserve (DOR). Microplastics and nanoplastics (MNPs) are widespread in the environment and pose health risks. The effect of MNPs on ovarian function remains uncertain.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"395 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trastuzumab profoundly improves outcomes of Her2+ breast cancer (BC) patients, but eventual drug resistance is inevitable. Therefore, new treatment options are urgently needed. Here, we modify extracellular vesicles (EVs) with a Her2 single-chain variable fragment of trastuzumab (EVs/Her2-scFv) to target Her2+ BC and found that EVs/Her2-scFv inhibit human Her2+ orthotopic BC comparable to trastuzumab and also uniquely suppress brain metastasies. Moreover, EVs/Her2-scFv loaded with rabeprazole (EVs/Her2-scFv/Rabe) effectively improve tumor immunosuppressive microenvironment and abnormal vasculature of Her2+ BC by reducing tumor EVs. When further anchored with CD8+ T cell chemotactic CXCL9, CXCL9-loaded EVs/Her2-scFv/Rabe (EVs/Her2-scFv/CXCL9/Rabe) facilitate CD8+ T cell recruitment and subsequent activation, thereby exhibiting immunotherapeutic effects on mouse Her2+ BC. In BC patient-derived tumor organoids (PDOs) and peripheral blood mononuclear cell coculture systems, EVs/Her2-scFv/CXCL9/Rabe limit PDO growth by blocking Her2 signaling and activating CD8+ T cells. Besides, EVs/Her2-scFv/CXCL9/Rabe are low-immunogenic with biosafety. Altogether, EVs/Her2-scFv/CXCL9/Rabe hold high potential in Her2+ BC therapy.
{"title":"A novel extracellular vesicle-engineered immunotherapy drug for Her2+ breast cancer","authors":"Xinliang Lu, Weiyi Yuan, Xianchang Zeng, Fanghui Zhang, Chengyan Zhang, Xinrong Li, Jufeng Guo, Jiayue Hao, Gensheng Zhang, Jianli Wang, Hao Wu, Zhijian Cai","doi":"10.1016/j.jare.2026.01.067","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.067","url":null,"abstract":"Trastuzumab profoundly improves outcomes of Her2<sup>+</sup> breast cancer (BC) patients, but eventual drug resistance is inevitable. Therefore, new treatment options are urgently needed. Here, we modify extracellular vesicles (EVs) with a Her2 single-chain variable fragment of trastuzumab (EVs/Her2-scFv) to target Her2<sup>+</sup> BC and found that EVs/Her2-scFv inhibit human Her2<sup>+</sup> orthotopic BC comparable to trastuzumab and also uniquely suppress brain metastasies. Moreover, EVs/Her2-scFv loaded with rabeprazole (EVs/Her2-scFv/Rabe) effectively improve tumor immunosuppressive microenvironment and abnormal vasculature of Her2<sup>+</sup> BC by reducing tumor EVs. When further anchored with CD8<sup>+</sup> T cell chemotactic CXCL9, CXCL9-loaded EVs/Her2-scFv/Rabe (EVs/Her2-scFv/CXCL9/Rabe) facilitate CD8<sup>+</sup> T cell recruitment and subsequent activation, thereby exhibiting immunotherapeutic effects on mouse Her2<sup>+</sup> BC. In BC patient-derived tumor organoids (PDOs) and peripheral blood mononuclear cell coculture systems, EVs/Her2-scFv/CXCL9/Rabe limit PDO growth by blocking Her2 signaling and activating CD8<sup>+</sup> T cells. Besides, EVs/Her2-scFv/CXCL9/Rabe are low-immunogenic with biosafety. Altogether, EVs/Her2-scFv/CXCL9/Rabe hold high potential in Her2<sup>+</sup> BC therapy.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"28 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146043084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vegetable processing generates large quantities of lignocellulosic waste that are often underutilized. Developing bioactive, biodegradable packaging materials from such residues aligns with circular bioeconomy goals. This study explores oxalic acid-choline chloride deep eutectic solvent (DES) fractionation as a green approach to valorize artichoke bracts, pea pods, and bean pods into high-performance lignocellulosic bioplastics.
{"title":"Regenerated lignocellulosic material from pea, bean, and artichoke waste as feedstock for bioplastic production","authors":"Cyrine Amara, Safa Baraketi, Yosr Barchouchi, Yassine M’Rabet, Wiem Ayadi, Mabrouk Horchani, Khaoula Khwaldia","doi":"10.1016/j.jare.2026.01.056","DOIUrl":"https://doi.org/10.1016/j.jare.2026.01.056","url":null,"abstract":"Vegetable processing generates large quantities of lignocellulosic waste that are often underutilized. Developing bioactive, biodegradable packaging materials from such residues aligns with circular bioeconomy goals. This study explores oxalic acid-choline chloride deep eutectic solvent (DES) fractionation as a green approach to valorize artichoke bracts, pea pods, and bean pods into high-performance lignocellulosic bioplastics.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"117 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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