Pub Date : 2026-03-20DOI: 10.1016/j.jare.2026.03.037
Rong Fu, Yang Zhao, Yayi Li, Yuliang Zhang, Meidan Wang, Zhuo Wang, Ming-sheng Zhou, Yueyang Liu
Background
Current therapeutic models for ischemic stroke (IS) are shifting from a narrow focus on neuroprotection to a broader concept of cytoprotection. This new paradigm emphasizes rescuing damaged brain cells and maintaining their structural and functional integrity through organelle transfer between healthy and damaged cells. Mounting evidence have supported that intracellular mitochondrial transfer is an intrinsic response to IS, playing a critical role in mitigating neural damage. Consequently, mitochondrial transplantation from stem cell is emerging as a therapeutic avenue for IS.
Aim of review
This article reviews the IS-induced mitochondrial dysfunction, the modes and mechanisms of endogenous intracellular mitochondrial transfer, and recent advances in using stem cell-derived mitochondrial transplantation to treat IS.
Key scientific concepts
This review emphasizes the dual roles of mitochondrial transfer in determining neural cells fate and neurological function recovery following IS. On one hand, health cells can donate intact mitochondria to damaged cells, to revitalize them by restoring cell metabolic function. On the other hand, damaged cell may expel dysfunction mitochondria, which can be cleared by healthy neighbors or, alternatively propagate injury. We discuss the current challenges in this field and propose that enhancing healthy mitochondrial transfer or preventing damaged mitochondrial release may hold great potential for alleviating IS injury.
{"title":"Intracellular mitochondrial transfer in ischemic stroke: Mechanisms and therapeutic application","authors":"Rong Fu, Yang Zhao, Yayi Li, Yuliang Zhang, Meidan Wang, Zhuo Wang, Ming-sheng Zhou, Yueyang Liu","doi":"10.1016/j.jare.2026.03.037","DOIUrl":"https://doi.org/10.1016/j.jare.2026.03.037","url":null,"abstract":"<h3>Background</h3>Current therapeutic models for ischemic stroke (IS) are shifting from a narrow focus on neuroprotection to a broader concept of cytoprotection. This new paradigm emphasizes rescuing damaged brain cells and maintaining their structural and functional integrity through organelle transfer between healthy and damaged cells. Mounting evidence have supported that intracellular mitochondrial transfer is an intrinsic response to IS, playing a critical role in mitigating neural damage. Consequently, mitochondrial transplantation from stem cell is emerging as a therapeutic avenue for IS.<h3>Aim of review</h3>This article reviews the IS-induced mitochondrial dysfunction, the modes and mechanisms of endogenous intracellular mitochondrial transfer, and recent advances in using stem cell-derived mitochondrial transplantation to treat IS.<h3>Key scientific concepts</h3>This review emphasizes the dual roles of mitochondrial transfer in determining neural cells fate and neurological function recovery following IS. On one hand, health cells can donate intact mitochondria to damaged cells, to revitalize them by restoring cell metabolic function. On the other hand, damaged cell may expel dysfunction mitochondria, which can be cleared by healthy neighbors or, alternatively propagate injury. We discuss the current challenges in this field and propose that enhancing healthy mitochondrial transfer or preventing damaged mitochondrial release may hold great potential for alleviating IS injury.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"7 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147492693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-19DOI: 10.1016/j.jare.2026.03.039
Yuting Chen, Xu Li, Chaochao Luo, Guanchuan Lin, Xuewen Zhou, Zebin Wen, Huanhou Su, Wei Meng, Caiming Chen, Jiameng Lu, Xingguang Luo, Deke Jiang, Hui Liu, Zhenyuan Ning, Yan Chen, Paul KH Tam, Xinghua Pan
Introduction
Cancer stem cells are critically involved in the initiation and progression of hepatocellular carcinoma (HCC). Understanding their biological properties and underlying mechanisms is essential for the development of effective targeted therapies.
Objectives
This study aims to identify the key stem-like cell subtype and elucidate the molecular mechanisms underlying its tumor-promoting effects in HCC.
Methods
Single-nucleus RNA sequencing (snRNA-seq) of the c-Myc/CreAlb transgenic HCC mouse model and single-cell RNA sequencing (scRNA-seq) from HCC patients were analyzed to identify key tumorigenic subpopulation with stemness properties. Integrated analysis of snRNA/scRNA-seq, bulk RNA sequencing, and spatial transcriptomics data elucidated the biological features, molecular signatures, and intercellular interactions of the identified subpopulation. In vitro experiments were performed to validate the functional role of the key regulatory factor. A risk score model based on relevant gene signatures was subsequently developed to evaluate the clinical significance.
Results
We mapped the hepatic transcriptomic landscape of the c-Myc/CreAlb transgenic HCC mouse model using snRNA-seq and identified cancer stem-like cells (CSLCs) with pronounced stemness properties as key drivers of HCC progression. scRNA-seq analysis of HCC patient tissues reveals that patient-derived CSLCs exhibited cross-species similarities with mouse-derived CSLCs and were strongly associated with tumor metastasis and poor prognosis. CSLCs actively suppressed lipid peroxidation and exhibited significant ferroptosis resistance, facilitating their survival within the tumor microenvironment. Mechanistically, MYB Proto-Oncogene Like 2 (MYBL2) was specifically activated in CSLCs, and MYBL2 knockdown effectively impaired cancer stemness and reduced ferroptosis resistance. Notably, our newly developed six-gene CSLC signature (CSLC.Sig) model achieved excellent prognostic prediction in HCC. Furthermore, strong interaction and spatial “neighborhood” localization were observed between CSLCs and activated hepatic stellate cells, indicating a synergistic pro-tumorigenic niche.
Conclusion
Our study identifies MYBL2-driven CSLCs as critical players in maintaining cancer stemness and ferroptosis resistance, providing potential therapeutic targets to disrupt CSLCs-mediated tumor progression in HCC.
{"title":"Omics insights into MYBL2-promoted cancer stem-like cells driving ferroptosis resistance in hepatocellular carcinoma","authors":"Yuting Chen, Xu Li, Chaochao Luo, Guanchuan Lin, Xuewen Zhou, Zebin Wen, Huanhou Su, Wei Meng, Caiming Chen, Jiameng Lu, Xingguang Luo, Deke Jiang, Hui Liu, Zhenyuan Ning, Yan Chen, Paul KH Tam, Xinghua Pan","doi":"10.1016/j.jare.2026.03.039","DOIUrl":"https://doi.org/10.1016/j.jare.2026.03.039","url":null,"abstract":"<h3>Introduction</h3>Cancer stem cells are critically involved in the initiation and progression of hepatocellular carcinoma (HCC). Understanding their biological properties and underlying mechanisms is essential for the development of effective targeted therapies.<h3>Objectives</h3>This study aims to identify the key stem-like cell subtype and elucidate the molecular mechanisms underlying its tumor-promoting effects in HCC.<h3>Methods</h3>Single-nucleus RNA sequencing (snRNA-seq) of the <em>c-Myc/Cre<sup>Alb</sup></em> transgenic HCC mouse model and single-cell RNA sequencing (scRNA-seq) from HCC patients were analyzed to identify key tumorigenic subpopulation with stemness properties. Integrated analysis of snRNA/scRNA-seq, bulk RNA sequencing, and spatial transcriptomics data elucidated the biological features, molecular signatures, and intercellular interactions of the identified subpopulation. <em>In vitro</em> experiments were performed to validate the functional role of the key regulatory factor. A risk score model based on relevant gene signatures was subsequently developed to evaluate the clinical significance.<h3>Results</h3>We mapped the hepatic transcriptomic landscape of the <em>c-Myc/Cre<sup>Alb</sup></em> transgenic HCC mouse model using snRNA-seq and identified cancer stem-like cells (CSLCs) with pronounced stemness properties as key drivers of HCC progression. scRNA-seq analysis of HCC patient tissues reveals that patient-derived CSLCs exhibited cross-species similarities with mouse-derived CSLCs and were strongly associated with tumor metastasis and poor prognosis. CSLCs actively suppressed lipid peroxidation and exhibited significant ferroptosis resistance, facilitating their survival within the tumor microenvironment. Mechanistically, MYB Proto-Oncogene Like 2 (MYBL2) was specifically activated in CSLCs, and MYBL2 knockdown effectively impaired cancer stemness and reduced ferroptosis resistance. Notably, our newly developed six-gene CSLC signature (CSLC.Sig) model achieved excellent prognostic prediction in HCC. Furthermore, strong interaction and spatial “neighborhood” localization were observed between CSLCs and activated hepatic stellate cells, indicating a synergistic pro-tumorigenic niche.<h3>Conclusion</h3>Our study identifies MYBL2-driven CSLCs as critical players in maintaining cancer stemness and ferroptosis resistance, providing potential therapeutic targets to disrupt CSLCs-mediated tumor progression in HCC.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"89 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147478666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<h3>Introduction</h3>Social determinants of health (SDoH) significantly influence female reproductive health. However, existing research has predominantly focused on examining the impact of SDoH on individual reproductive health indicators, lacking comprehensive assessments of their cumulative effects on overall reproductive health and systematic evaluations of multidimensional SDoH exposures. Investigating the influence of SDoH on reproductive health under conditions of cross-national comparability holds critical public health significance for advancing health equity goals.<h3>Objectives</h3>To explore the association between multidimensional SDoH scores and the composite reproductive health index (RRS) and to identify potential causal mechanisms. Additionally, to assess whether the impact of SDoH on reproductive health varies based on individual behavioral characteristics and/or metabolic health status.<h3>Methods</h3>This cross-sectional study analyzed data from the UK Biobank (UKB, n = 12,512) and the US National Health and Nutrition Examination Survey (NHANES, n = 2,834). Weighted and unweighted SDoH scores were constructed based on the five core domains outlined in Healthy People 2030. The reproductive risk score (RRS) was derived from 17 (UKB) and 12 (NHANES) reproductive health variables, respectively. Multivariable linear regression models were employed to assess the association between SDoH and RRS, supplemented by subgroup and interaction analyses. Additionally, two-sample Mendelian randomization (MR) was performed using genome-wide association study (GWAS) summary statistics to evaluate potential causal relationships between educational attainment and 13 RRS-related variables.<h3>Results</h3>Higher SDoH scores (indicating greater disadvantage) were linearly associated with increased RRS in both cohorts (UKB: Unweighted SDoH score: <em>β</em> = 0.048, 95% CI = 0.037, 0.059, <em>P</em> < 0.001; Weighted SDoH score: <em>β</em> = 0.100, 95% CI = 0.084, 0.117, <em>P</em> < 0.001. NHANES: Unweighted SDoH score: <em>β</em> = 0.118, 95% CI = 0.065, 0.171, <em>P</em> < 0.001; Weighted SDoH score: <em>β</em> = 0.129, 95% CI = 0.078, 0.180, <em>P</em> < 0.001). Compared with the favorable SDoH group, the unfavorable SDoH group exhibited significantly higher RRS in the UKB population (Unweighted: <em>β</em> = 0.237, 95% CI = 0.172, 0.302, <em>P</em> < 0.001; Weighted: <em>β</em> = 0.309, 95% CI = 0.243, 0.375, <em>P</em> < 0.001). In the NHANES population, both the medium SDoH group (Unweighted: <em>β</em> = 0.409, 95% CI = 0.095, 0.723, <em>P</em> = 0.011; Weighted: <em>β</em> = 0.378, 95% CI = 0.082, 0.674, <em>P</em> = 0.013) and the unfavorable SDoH group (Unweighted: <em>β</em> = 0.432, 95% CI = 0.118, 0.747, <em>P</em> = 0.008; Weighted: <em>β</em> = 0.613, 95% CI = 0.278, 0.947, <em>P</em> < 0.001) demonstrated significantly elevated RRS. Subgroup analyses revealed effect modification by age, BMI, diabetes status, smok
健康的社会决定因素（SDoH）显著影响女性生殖健康。然而，现有的研究主要集中在检查SDoH对个人生殖健康指标的影响，缺乏对其对总体生殖健康的累积影响的综合评估和对多维SDoH暴露的系统评估。在跨国可比性条件下，研究SDoH对生殖健康的影响对推进卫生公平目标具有重要的公共卫生意义。目的探讨多维SDoH评分与生殖健康综合指数（RRS）的关系，并探讨可能的因果机制。此外，评估SDoH对生殖健康的影响是否因个人行为特征和/或代谢健康状况而异。方法本横断面研究分析了来自英国生物银行（UKB, n = 12,512）和美国国家健康与营养检查调查（NHANES, n = 2,834）的数据。加权和非加权SDoH评分是基于《健康人2030》概述的五个核心领域构建的。生殖风险评分（RRS）分别由17个（UKB）和12个（NHANES）生殖健康变量得出。采用多变量线性回归模型评估SDoH与RRS之间的关系，并辅以亚组分析和相互作用分析。此外，使用全基因组关联研究（GWAS）汇总统计进行双样本孟德尔随机化（MR），以评估受教育程度与13个rrs相关变量之间的潜在因果关系。ResultsHigher SDoH分数(表明更大的缺点)是线性增加的RRS两个组别(UKB:未加权的SDoH得分:β = 0.048,95% CI = 0.037,0.059,P & lt; 0.001;加权SDoH得分:β = 0.100,95% CI = 0.084,0.117,P & lt; 0.001。NHANES：未加权SDoH评分：β = 0.118,95% CI = 0.065,0.171,P <； 0.001；加权SDoH得分:β = 0.129,95% CI = 0.078,0.180,P & lt; 0.001)。与有利SDoH组相比,不宜SDoH组表现出明显高于RRS UKB人群(未加权的:β = 0.237,95% CI = 0.172,0.302,P & lt; 0.001;加权:β = 0.309,95% CI = 0.243,0.375,P & lt; 0.001)。NHANES人口,媒介SDoH组(未加权的:β = 0.409,95% CI = 0.095,0.723,P = 0.011;加权:β = 0.378,95% CI = 0.082,0.674,P = 0.013)和不利SDoH组(未加权的:β = 0.432,95% CI = 0.118,0.747,P = 0.008;加权:β = 0.613,95% CI = 0.278,0.947,P & lt; 0.001)证明RRS显著升高。亚组分析显示，年龄、身体质量指数、糖尿病状况、吸烟和体育活动会改变效果。孟德尔随机化（MR）分析发现，受教育程度与6个rrs相关变量之间存在显著的因果关系，与1个变量呈负相关，与6个变量无显著相关。结论本研究首次提供了SDoH评分与女性生殖风险呈正量效关系的系统证据。研究结果强调了SDoH影响生殖健康的复杂多途径机制，受行为和代谢因素的调节。这些结果强调了有针对性的社会经济干预的重要性，包括改善教育机会、经济支持和改善社会环境，以减轻妇女生殖健康结果的差异。
{"title":"Social determinants of health and female reproductive health: risk score development and cross-national study based on multi-national analysis","authors":"Yu Guan, Wenzhu Li, Feng Zhang, Sirui Liu, Weiqian Zhang, Jia Liang, Ruhui Zhan, Juan He, Tailang Yin, Jue Liu, Dongdong Tang, Yan Zhang","doi":"10.1016/j.jare.2026.03.038","DOIUrl":"https://doi.org/10.1016/j.jare.2026.03.038","url":null,"abstract":"<h3>Introduction</h3>Social determinants of health (SDoH) significantly influence female reproductive health. However, existing research has predominantly focused on examining the impact of SDoH on individual reproductive health indicators, lacking comprehensive assessments of their cumulative effects on overall reproductive health and systematic evaluations of multidimensional SDoH exposures. Investigating the influence of SDoH on reproductive health under conditions of cross-national comparability holds critical public health significance for advancing health equity goals.<h3>Objectives</h3>To explore the association between multidimensional SDoH scores and the composite reproductive health index (RRS) and to identify potential causal mechanisms. Additionally, to assess whether the impact of SDoH on reproductive health varies based on individual behavioral characteristics and/or metabolic health status.<h3>Methods</h3>This cross-sectional study analyzed data from the UK Biobank (UKB, n = 12,512) and the US National Health and Nutrition Examination Survey (NHANES, n = 2,834). Weighted and unweighted SDoH scores were constructed based on the five core domains outlined in Healthy People 2030. The reproductive risk score (RRS) was derived from 17 (UKB) and 12 (NHANES) reproductive health variables, respectively. Multivariable linear regression models were employed to assess the association between SDoH and RRS, supplemented by subgroup and interaction analyses. Additionally, two-sample Mendelian randomization (MR) was performed using genome-wide association study (GWAS) summary statistics to evaluate potential causal relationships between educational attainment and 13 RRS-related variables.<h3>Results</h3>Higher SDoH scores (indicating greater disadvantage) were linearly associated with increased RRS in both cohorts (UKB: Unweighted SDoH score: <em>β</em> = 0.048, 95% CI = 0.037, 0.059, <em>P</em> < 0.001; Weighted SDoH score: <em>β</em> = 0.100, 95% CI = 0.084, 0.117, <em>P</em> < 0.001. NHANES: Unweighted SDoH score: <em>β</em> = 0.118, 95% CI = 0.065, 0.171, <em>P</em> < 0.001; Weighted SDoH score: <em>β</em> = 0.129, 95% CI = 0.078, 0.180, <em>P</em> < 0.001). Compared with the favorable SDoH group, the unfavorable SDoH group exhibited significantly higher RRS in the UKB population (Unweighted: <em>β</em> = 0.237, 95% CI = 0.172, 0.302, <em>P</em> < 0.001; Weighted: <em>β</em> = 0.309, 95% CI = 0.243, 0.375, <em>P</em> < 0.001). In the NHANES population, both the medium SDoH group (Unweighted: <em>β</em> = 0.409, 95% CI = 0.095, 0.723, <em>P</em> = 0.011; Weighted: <em>β</em> = 0.378, 95% CI = 0.082, 0.674, <em>P</em> = 0.013) and the unfavorable SDoH group (Unweighted: <em>β</em> = 0.432, 95% CI = 0.118, 0.747, <em>P</em> = 0.008; Weighted: <em>β</em> = 0.613, 95% CI = 0.278, 0.947, <em>P</em> < 0.001) demonstrated significantly elevated RRS. Subgroup analyses revealed effect modification by age, BMI, diabetes status, smok","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"11 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147478664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The evolution of insecticide resistance is often accompanied by fitness costs on life-history traits; however, the genetic mechanisms underlying this ’benefit-cost’ trade-offs remain limited.
{"title":"The pleiotropic effects of a single transcription factor underpin trade-offs associated with insecticide resistance in whitefly","authors":"Mingjiao Huang, Shaonan Liu, Buli Fu, Peipan Gong, Xiaojie Wu, Cheng Yin, Hu Xue, Jing Yang, Qimei Tan, Yating Liu, Xin Yang, Youjun Zhang","doi":"10.1016/j.jare.2026.03.033","DOIUrl":"https://doi.org/10.1016/j.jare.2026.03.033","url":null,"abstract":"The evolution of insecticide resistance is often accompanied by fitness costs on life-history traits; however, the genetic mechanisms underlying this ’benefit-cost’ trade-offs remain limited.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"5 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gut microbiota is a key player in colorectal cancer (CRC) proliferation. Parvimonas micra (P. micra), an obligate anaerobic bacterium that colonizes the oral cavity and gastrointestinal tract, has been implicated in CRC development. However, its virulence factors and pathogenic mechanisms remain poorly understood.
{"title":"Parvimonas micra-derived SirTM: An ADP-ribosyltransferase as a novel driver in colorectal cancer progression","authors":"Yuxiao Chang, Chao Yang, Fengyi Hou, Yubing Zhu, Ziran Huang, Likun Wang, Yuejiao Liu, Huan Zhang, Xiaoming Qin, Zichuang Hao, Dong Li, Yafang Tan, Yinlan Bai, Lei Ding, Hong Gao, Fachao Zhi, Fanglin Zhang, Yujing Bi, Ruifu Yang","doi":"10.1016/j.jare.2026.03.035","DOIUrl":"https://doi.org/10.1016/j.jare.2026.03.035","url":null,"abstract":"Gut microbiota is a key player in colorectal cancer (CRC) proliferation. <ce:italic>Parvimonas micra</ce:italic> (<ce:italic>P. micra</ce:italic>), an obligate anaerobic bacterium that colonizes the oral cavity and gastrointestinal tract, has been implicated in CRC development. However, its virulence factors and pathogenic mechanisms remain poorly understood.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"87 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-17DOI: 10.1016/j.jare.2026.03.032
Man Zhu, Xiaoyu Tang, Zeren Zhu, Wenjun Tang, Yumeng Cheng, Wenjuan Tang, Qianqian Zhang, Longyu Qin, Suyu Zhang, Yanmin Zhang
Cisplatin resistance is a major obstacle in the treatment of non-small cell lung cancer (NSCLC) and remains a leading cause of cancer-related deaths worldwide. This resistance substantially reduces the efficacy of cisplatin and highlights the need for innovative therapeutic strategies.
{"title":"Sting-driven mitochondrial metabolism reverses cisplatin resistance via MDH2 desuccinylation in non-small cell lung cancer","authors":"Man Zhu, Xiaoyu Tang, Zeren Zhu, Wenjun Tang, Yumeng Cheng, Wenjuan Tang, Qianqian Zhang, Longyu Qin, Suyu Zhang, Yanmin Zhang","doi":"10.1016/j.jare.2026.03.032","DOIUrl":"https://doi.org/10.1016/j.jare.2026.03.032","url":null,"abstract":"Cisplatin resistance is a major obstacle in the treatment of non-small cell lung cancer (NSCLC) and remains a leading cause of cancer-related deaths worldwide. This resistance substantially reduces the efficacy of cisplatin and highlights the need for innovative therapeutic strategies.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"11 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dietary intervention has emerged as a key strategy not only for health control but also for disease treatment. Growing evidence indicates that dietary interventions (including caloric restriction, intermittent fasting, time-restricted feeding, fasting-mimicking diet, and ketogenic diet) significantly influence immune homeostasis and orchestrate immune responses, offering potential as adjuvant therapies in autoimmune diseases, cancer, and other immune-related conditions.
{"title":"Dietary intervention & immunity: underlying mechanisms and future directions","authors":"Jiamin Zhao, Xin Li, Yidan Liang, Tengkun Dai, Chao Chen, Mengmeng Guo, Xu Zhao, Lin Xu","doi":"10.1016/j.jare.2026.03.026","DOIUrl":"https://doi.org/10.1016/j.jare.2026.03.026","url":null,"abstract":"Dietary intervention has emerged as a key strategy not only for health control but also for disease treatment. Growing evidence indicates that dietary interventions (including caloric restriction, intermittent fasting, time-restricted feeding, fasting-mimicking diet, and ketogenic diet) significantly influence immune homeostasis and orchestrate immune responses, offering potential as adjuvant therapies in autoimmune diseases, cancer, and other immune-related conditions.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"11 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-17DOI: 10.1016/j.jare.2026.03.031
Chao-Feng Shi, Fei Han, Xiao Jiang, Lei Sun, Kang-le Liu, Sheng-qi Sun, Ying-qing Li, Jian-kang Wang, Lin Ao, Jia Cao, Qing Chen, Jin-yi Liu
Mitochondrial homeostasis is intimately associated with the toxic effects of exogenous chemicals, as well as the onset and progression of various diseases. Benzo[b]fluoranthene (BbF) is ubiquitously distributed across various environmental media. The association between BbF exposure and male reproductive damage has been recently discovered. However, the relevant mechanisms remain unexplored.
{"title":"The m6A modification mediates the imbalance of mitochondrial homeostasis and apoptosis induced by Benzo[b]fluoranthene in mouse spermatocytes: mitophagy versus mitochondrial damage","authors":"Chao-Feng Shi, Fei Han, Xiao Jiang, Lei Sun, Kang-le Liu, Sheng-qi Sun, Ying-qing Li, Jian-kang Wang, Lin Ao, Jia Cao, Qing Chen, Jin-yi Liu","doi":"10.1016/j.jare.2026.03.031","DOIUrl":"https://doi.org/10.1016/j.jare.2026.03.031","url":null,"abstract":"Mitochondrial homeostasis is intimately associated with the toxic effects of exogenous chemicals, as well as the onset and progression of various diseases. Benzo[b]fluoranthene (BbF) is ubiquitously distributed across various environmental media. The association between BbF exposure and male reproductive damage has been recently discovered. However, the relevant mechanisms remain unexplored.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"24 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-17DOI: 10.1016/j.jare.2026.03.029
Jiaxin Su, Lingcheng Wu, Huiru Zhu, Haoru Wang, Xiaoya He, Bing Liang, Jinhua Cai
Acute kidney injury (AKI) is a devastating global health burden. Its pathogenesis, particularly in ischemia/reperfusion (I/R) injury, centers on a vicious cycle between a reactive oxygen species (ROS)-driven inflammatory storm and severe mitochondrial dysfunction in renal tubular cells. While activation of the SIRT1/PGC-1α pathway is a promising therapeutic target for mitochondrial recovery, its potent agonist resveratrol (Rsv) suffers from poor bioavailability, and monotherapy fails to address the concomitant inflammatory pathology.
{"title":"A Rsv@HMnO2-HA nanozyme for AKI therapy via targeting inflammatory storm and activating SIRT1/PGC-1α to restore mitochondrial homeostasis","authors":"Jiaxin Su, Lingcheng Wu, Huiru Zhu, Haoru Wang, Xiaoya He, Bing Liang, Jinhua Cai","doi":"10.1016/j.jare.2026.03.029","DOIUrl":"https://doi.org/10.1016/j.jare.2026.03.029","url":null,"abstract":"Acute kidney injury (AKI) is a devastating global health burden. Its pathogenesis, particularly in ischemia/reperfusion (I/R) injury, centers on a vicious cycle between a reactive oxygen species (ROS)-driven inflammatory storm and severe mitochondrial dysfunction in renal tubular cells. While activation of the SIRT1/PGC-1α pathway is a promising therapeutic target for mitochondrial recovery, its potent agonist resveratrol (Rsv) suffers from poor bioavailability, and monotherapy fails to address the concomitant inflammatory pathology.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"1 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-17DOI: 10.1016/j.jare.2026.03.027
Wei Liu, Zhiqiang Zhang, Qiying Du, Jianing Li, Liuqi Yang, Zhongying Ren, Jiameng Guo, Wei Zhu, Zongbin Ma, Yang Zhou, Wei Li
Histone modifications are among the key epigenetic regulators of gene expression in plants under abiotic stress, particularly in modulating stress responses by activating or repressing specific genes. Nevertheless, the epigenetic basis of the salt stress response in cotton remains largely unknown, despite its comparative salt tolerance.
{"title":"H3K27me3-mediated chromatin remodeling governs salt tolerance in cotton via Na+/K+ homeostasis modulation","authors":"Wei Liu, Zhiqiang Zhang, Qiying Du, Jianing Li, Liuqi Yang, Zhongying Ren, Jiameng Guo, Wei Zhu, Zongbin Ma, Yang Zhou, Wei Li","doi":"10.1016/j.jare.2026.03.027","DOIUrl":"https://doi.org/10.1016/j.jare.2026.03.027","url":null,"abstract":"Histone modifications are among the key epigenetic regulators of gene expression in plants under abiotic stress, particularly in modulating stress responses by activating or repressing specific genes. Nevertheless, the epigenetic basis of the salt stress response in cotton remains largely unknown, despite its comparative salt tolerance.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"94 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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