S. Daliri, K. Asadollahi, Mir Hadi Musavi, Arezou Karimi, Gholamreza Khademi, M. Azizi, G. Abangah
Introduction: Glucose-6-phosphate dehydrogenase deficiency (G6PD) or fauvism is the most common enzyme deficiency in human, so that 400 million people are living with this disease worldwide. This study aimed to investigate the role of some neonatal factors among newborns suffering from G6PD deficiency and neonatal outcomes associated with this disease. Materials and methods: In this study, two methods including case-control and retrospective cohort regarding some neonatal factors associated with G6PD deficiency were used. These methods were performed on 142 children with this kind of deficiency and 142 healthy infants in the city of Marvdasht during 2013- 2014. The analysis of data was based on chi-square tests, t-test, logistic regression, descriptive statistics and estimation of odds ratios or relative risks via SPSS16 software. Results: Totally 284 newborns including 132 (46.6%)/ 152 (53.4%) boys/girls and mean weight on birth of 3163 ± 471 (gr) were analyzed. Comparison of case and control samples did not show any significant differences between sex and involving with G6PD deficiency but the chance of having a baby with this defect in pregnancy intervals between 6 to 8 years was increased (95% CI: 1- 4.4, OR: 2). Relative risk of jaundice in infected and healthy infants was estimated as 3.73, which demonstrated a statistically significant association (95% CI: 1.33- 10.4). The frequency of low birth weight, birth order and type of delivery was associated with the disease, but their differences were insignificant compared to the healthy group. Conclusion: The results of this study showed that the number of hospitalization is increased due to jaundice in infants with G6PD. There is also an insignificant relation between low birth weight, rank of birth and type of delivery. Thus, it is recommended that other consequences of this deficiency need to be revealed by screening other populations with more samples.
{"title":"The relationship between neonatal factors and involving with glucose-6-phosphate dehydrogenase deficiency (G6PD) and patients' outcome in Fars Province","authors":"S. Daliri, K. Asadollahi, Mir Hadi Musavi, Arezou Karimi, Gholamreza Khademi, M. Azizi, G. Abangah","doi":"10.29252/JBRMS.5.1.15","DOIUrl":"https://doi.org/10.29252/JBRMS.5.1.15","url":null,"abstract":"Introduction: Glucose-6-phosphate dehydrogenase deficiency (G6PD) or fauvism is the most common enzyme deficiency in human, so that 400 million people are living with this disease worldwide. This study aimed to investigate the role of some neonatal factors among newborns suffering from G6PD deficiency and neonatal outcomes associated with this disease. Materials and methods: In this study, two methods including case-control and retrospective cohort regarding some neonatal factors associated with G6PD deficiency were used. These methods were performed on 142 children with this kind of deficiency and 142 healthy infants in the city of Marvdasht during 2013- 2014. The analysis of data was based on chi-square tests, t-test, logistic regression, descriptive statistics and estimation of odds ratios or relative risks via SPSS16 software. Results: Totally 284 newborns including 132 (46.6%)/ 152 (53.4%) boys/girls and mean weight on birth of 3163 ± 471 (gr) were analyzed. Comparison of case and control samples did not show any significant differences between sex and involving with G6PD deficiency but the chance of having a baby with this defect in pregnancy intervals between 6 to 8 years was increased (95% CI: 1- 4.4, OR: 2). Relative risk of jaundice in infected and healthy infants was estimated as 3.73, which demonstrated a statistically significant association (95% CI: 1.33- 10.4). The frequency of low birth weight, birth order and type of delivery was associated with the disease, but their differences were insignificant compared to the healthy group. Conclusion: The results of this study showed that the number of hospitalization is increased due to jaundice in infants with G6PD. There is also an insignificant relation between low birth weight, rank of birth and type of delivery. Thus, it is recommended that other consequences of this deficiency need to be revealed by screening other populations with more samples.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":"5 1","pages":"15-21"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69859264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Adipose tissue and inflammatory factors play important role in occurrence of atherosclerosis in overweight women. The present study aimed to investigate the effect of 8 weeks of aerobic exercise training on risk factors involved in atherosclerosis in overweight women. Materials and methods: For this, fourteen overweight women (mean ± standard deviation: body mass index 28.49 ± 3.28 k/m2 and body fat 35.01 ± 3.68%) conducted aerobic exercise training for 8 weeks (at intensity correspond with 65 to 80 % reserved heart rate). Before and after aerobic exercise training, fasting blood samples were taken and anthropometrics characteristics were measured. The data were analyzed using Paired sample t-test (P<0.05). Results: Aerobic exercise training significantly increased maximal oxygen consumption in overweight women (P=0.001). In contrast, aerobic exercise training result in significant reduction in intracellular adhesion molecule 1 levels (P=0.013) and C-reactive protein (P=0.001). In addition, anthropometric measurements of body fat percentage (P=0.006), waist to hip ratio (P=0.01), and body mass index (P=0.001) showed a significant reduction, too. However, no significant change observed in platelet (P=0.127), high density lipoprotein (P=0.107), low density lipoprotein (P=0.095) and cholesterol (P=0.391) levels. Conclusion: Reduction in body fat following aerobic exercise training in overweight women is corresponding with a reduction in inflammatory markers involved in atherosclerosis.
{"title":"Aerobic exercise training reduces inflammatory markers involved in atherosclerosis","authors":"S. Nayebifar, H. TaheriChadorneshin","doi":"10.29252/JBRMS.5.1.29","DOIUrl":"https://doi.org/10.29252/JBRMS.5.1.29","url":null,"abstract":"Introduction: Adipose tissue and inflammatory factors play important role in occurrence of atherosclerosis in overweight women. The present study aimed to investigate the effect of 8 weeks of aerobic exercise training on risk factors involved in atherosclerosis in overweight women. Materials and methods: For this, fourteen overweight women (mean ± standard deviation: body mass index 28.49 ± 3.28 k/m2 and body fat 35.01 ± 3.68%) conducted aerobic exercise training for 8 weeks (at intensity correspond with 65 to 80 % reserved heart rate). Before and after aerobic exercise training, fasting blood samples were taken and anthropometrics characteristics were measured. The data were analyzed using Paired sample t-test (P<0.05). Results: Aerobic exercise training significantly increased maximal oxygen consumption in overweight women (P=0.001). In contrast, aerobic exercise training result in significant reduction in intracellular adhesion molecule 1 levels (P=0.013) and C-reactive protein (P=0.001). In addition, anthropometric measurements of body fat percentage (P=0.006), waist to hip ratio (P=0.01), and body mass index (P=0.001) showed a significant reduction, too. However, no significant change observed in platelet (P=0.127), high density lipoprotein (P=0.107), low density lipoprotein (P=0.095) and cholesterol (P=0.391) levels. Conclusion: Reduction in body fat following aerobic exercise training in overweight women is corresponding with a reduction in inflammatory markers involved in atherosclerosis.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":"5 1","pages":"29-37"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69859310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akram Aghamohammadi, M. Maghsoodlu, H. T. Naghadeh, Shirin Ferdowsi
An increase in the frequency of blood donation among the donor population is liable to result in excessive iron loss and development of iron deficiency anemia. In the majority of blood banks, hemoglobin and/or hematocrit measurements are used as screening tests for the ability to donate blood even though iron stores may be depleted in donors with hemoglobin values above the arbitrarily defined limit for anemia. In the present study, we have reviewed the iron deficiency in blood donors and characteristics which predispose to this condition
{"title":"Iron stores in blood donors: A literature mini review","authors":"Akram Aghamohammadi, M. Maghsoodlu, H. T. Naghadeh, Shirin Ferdowsi","doi":"10.29252/JBRMS.4.4.50","DOIUrl":"https://doi.org/10.29252/JBRMS.4.4.50","url":null,"abstract":"An increase in the frequency of blood donation among the donor population is liable to result in excessive iron loss and development of iron deficiency anemia. In the majority of blood banks, hemoglobin and/or hematocrit measurements are used as screening tests for the ability to donate blood even though iron stores may be depleted in donors with hemoglobin values above the arbitrarily defined limit for anemia. In the present study, we have reviewed the iron deficiency in blood donors and characteristics which predispose to this condition","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":"4 1","pages":"50-55"},"PeriodicalIF":0.0,"publicationDate":"2017-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49211911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Kamalvandi, I. Mohammadfam, Rozita Farhadi, M. Jalilian, N. Kurd
Introduction: construction is one of the most important industries in which many workers start on activity. Sometimes, these industries workers are victims of different occupational accidents and injuries. Therefore, the aim of this study was to determine the frequency and underlying reasons in construction accidents. Materials and methods: In this descriptive - analytical study, all construction workers (n = 347) who encountered with occupational accident were studied in Hamadan city, west of Iran. The data were extracted from health profiles of injured workers by checklist . Data were analyzed with SPSS 16 by applying of Chi square and Logistic regression tests at the significant level of P < 0.05. Results: During 2007-2010, 347 workers encountered with construction accidents and seven of them were died. Finding showed that fall and slip were cause of 36.59% of accidents. Also, carelessness was major predictor factor related to 80.96% of accidents. According to the results, 36.02% of these accidents were happened at 15.00 and 18.00 PM. Conclusion: Develop and discussion about organizing public policies is suggested to implement work safety programs for construction workers.
{"title":"Evaluation of work-related accidents among Hamadan construction workers","authors":"M. Kamalvandi, I. Mohammadfam, Rozita Farhadi, M. Jalilian, N. Kurd","doi":"10.29252/JBRMS.4.4.44","DOIUrl":"https://doi.org/10.29252/JBRMS.4.4.44","url":null,"abstract":"Introduction: construction is one of the most important industries in which many workers start on activity. Sometimes, these industries workers are victims of different occupational accidents and injuries. Therefore, the aim of this study was to determine the frequency and underlying reasons in construction accidents. Materials and methods: In this descriptive - analytical study, all construction workers (n = 347) who encountered with occupational accident were studied in Hamadan city, west of Iran. The data were extracted from health profiles of injured workers by checklist . Data were analyzed with SPSS 16 by applying of Chi square and Logistic regression tests at the significant level of P < 0.05. Results: During 2007-2010, 347 workers encountered with construction accidents and seven of them were died. Finding showed that fall and slip were cause of 36.59% of accidents. Also, carelessness was major predictor factor related to 80.96% of accidents. According to the results, 36.02% of these accidents were happened at 15.00 and 18.00 PM. Conclusion: Develop and discussion about organizing public policies is suggested to implement work safety programs for construction workers.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":"4 1","pages":"44-49"},"PeriodicalIF":0.0,"publicationDate":"2017-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44733982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Osteoporosis is a systemic skeletal disease with a consequent increase in bone fracture. The purpose of this study was to determine skeletal changes induced by two types of exercise therapy in osteoporotic rats. Materials and methods: Among 30 male rats, 6 of them were selected as healthy group, Then Osteoporosis induced in other rats by intraperitoneal injection of 20% ethanol solution (3g/kg/day) for 3 weeks. Osteoporotic rats divided into 4 groups: Baseline, resistance, endurance and control (n=6). The two exercise groups completed 12 weeks of training, 5 days/week according to protocols. Endurance protocol included running exercise on a treadmill for, 12 m/min, 10 to 64 min/ day. The Resistance training protocol consisted of 8 series of climbing on the 110cm vertical ladder angled at 80o with weights tied to animal tail that was increased from the 50% of the body mass of the animal in the first series to100% in the eighth series. At the end of the training, the animals were euthanized, and the BMD of the femur and the L4 + L5 vertebrae were measured using DXA and tensile max load of the tibia and compression max load of the L5 were measured applying Zwick 2.5 machine. The collected data was analyzed using paired t and one way ANOVA tests. Results: The two groups of the exercises had significantly increased femur BMD compared to controls (P=0.035, P=0.001). L4+L5 BMD in resistance training and control groups was significantly greater than endurance group (P=0.001, P=0.001). The tibia tensile maximum load and L5 maximum load in resistance group were significantly greater than control (P=0.01, P=0.03). Conclusion: Resistance training induces more effective favorable changes in bone mineral status and bone strength as compared to endurance exercise in osteoporotic male rat.
{"title":"The effect of two types exercise therapy on bone mineral density and mechanical strength of osteoporotic male rats","authors":"M. Banparvari, A. Salehikia, Fateme Azarm","doi":"10.29252/JBRMS.4.4.28","DOIUrl":"https://doi.org/10.29252/JBRMS.4.4.28","url":null,"abstract":"Introduction: Osteoporosis is a systemic skeletal disease with a consequent increase in bone fracture. The purpose of this study was to determine skeletal changes induced by two types of exercise therapy in osteoporotic rats. Materials and methods: Among 30 male rats, 6 of them were selected as healthy group, Then Osteoporosis induced in other rats by intraperitoneal injection of 20% ethanol solution (3g/kg/day) for 3 weeks. Osteoporotic rats divided into 4 groups: Baseline, resistance, endurance and control (n=6). The two exercise groups completed 12 weeks of training, 5 days/week according to protocols. Endurance protocol included running exercise on a treadmill for, 12 m/min, 10 to 64 min/ day. The Resistance training protocol consisted of 8 series of climbing on the 110cm vertical ladder angled at 80o with weights tied to animal tail that was increased from the 50% of the body mass of the animal in the first series to100% in the eighth series. At the end of the training, the animals were euthanized, and the BMD of the femur and the L4 + L5 vertebrae were measured using DXA and tensile max load of the tibia and compression max load of the L5 were measured applying Zwick 2.5 machine. The collected data was analyzed using paired t and one way ANOVA tests. Results: The two groups of the exercises had significantly increased femur BMD compared to controls (P=0.035, P=0.001). L4+L5 BMD in resistance training and control groups was significantly greater than endurance group (P=0.001, P=0.001). The tibia tensile maximum load and L5 maximum load in resistance group were significantly greater than control (P=0.01, P=0.03). Conclusion: Resistance training induces more effective favorable changes in bone mineral status and bone strength as compared to endurance exercise in osteoporotic male rat.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":"4 1","pages":"28-35"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42784686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Arani, M. Ghaneian, G. Halvani, Mahmoud Dakhilpour, Javad Delavar, H. Rezapour, Monireh Dehghani Arani, Moslem Tazik
Introduction: The steel industry is known as the most important consumer of energy and fuel. In doing so, ensuring safety of energy sources of a country needs to expect the risks analysis in order to select a comprehensive approach. This study aimed to identify the energy consumption and control measures available in the Hot Rolling Kavir Steel Complex and to conduct risk assessment by Energy Tracking and Barrier Analysis method (ETBA). Materials and methods: In this study, initially a team of experts identified mobilized energies and risks of the system and control measures using ETBA sheet that result of a standard MILSTD-882B. Then, the initial risk assessment was carried out using ETBA method. Finally, the control strategies were proposed and the secondary risk level was calculated. Results: Using ETBA, in total 19 energy types and 74 risk types were successfully identified so that in the first stage, 19 risks were unacceptable, 50 risks were unfavorable and 5 risks were acceptable for which the corrective strategies were required Then, the corrective revisions were proposed to reduce the risk level and calculate RAC2. Conclusion: Corrective controlling measures including safety, health and environmental training, continual monitoring and ongoing visit are effective using the safety equipment and personal protective equipment for reducing the unacceptable risks.
{"title":"Identification of hazardous and risk assessment of energy sources for Kavir Steel Complex using ETBA method in 2015","authors":"M. Arani, M. Ghaneian, G. Halvani, Mahmoud Dakhilpour, Javad Delavar, H. Rezapour, Monireh Dehghani Arani, Moslem Tazik","doi":"10.29252/JBRMS.4.4.18","DOIUrl":"https://doi.org/10.29252/JBRMS.4.4.18","url":null,"abstract":"Introduction: The steel industry is known as the most important consumer of energy and fuel. In doing so, ensuring safety of energy sources of a country needs to expect the risks analysis in order to select a comprehensive approach. This study aimed to identify the energy consumption and control measures available in the Hot Rolling Kavir Steel Complex and to conduct risk assessment by Energy Tracking and Barrier Analysis method (ETBA). Materials and methods: In this study, initially a team of experts identified mobilized energies and risks of the system and control measures using ETBA sheet that result of a standard MILSTD-882B. Then, the initial risk assessment was carried out using ETBA method. Finally, the control strategies were proposed and the secondary risk level was calculated. Results: Using ETBA, in total 19 energy types and 74 risk types were successfully identified so that in the first stage, 19 risks were unacceptable, 50 risks were unfavorable and 5 risks were acceptable for which the corrective strategies were required Then, the corrective revisions were proposed to reduce the risk level and calculate RAC2. Conclusion: Corrective controlling measures including safety, health and environmental training, continual monitoring and ongoing visit are effective using the safety equipment and personal protective equipment for reducing the unacceptable risks.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":"4 1","pages":"18-27"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43801070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Rafiei, P. Asgari, Razieh Mokhtari, Mohamad Golitaleb
Effect of Glycyrrhiza glabra extract and aerobic exercise on the attitude of postmenopausal women to menopause Parvaneh Asgari, Fatemeh Bahramnezhad *, Mohammad Golitaleb, Fatemeh Salehi, Razieh Mokhtari, Fatemeh Rafiei phd candidate Department of Nursing, Faculty of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran , bahramnezhad@razi.tums.ac.ir Abstract: Introduction: Menopause is associated with complications that can affect women's attitudes. Women's attitudes toward menopause can help to improve their performance and reduce the severity of its complications. The aim of this study was to evaluate the effect of Glycyrrhiza glabra (G. glabra) plant and exercise on the attitude of menopausal women. Materials and methods: This clinical experimental fourth group was conducted between October and March 2015 in Arak, Iran. 120 menopausal women were randomly selected and divided into four groups each containing 30 women. The first group had three G. glabra tablets daily for one month, the second group had a regular exercise program three times a week for 30-45 minutes for one month and the third group simultaneously took G. glabra like Group1 and followed exercise programs like Group 2 and the fourth group received no intervention. Before and one month after the intervention attitudes of women were compared with a researcher-made questionnaire. ANOVA, Chi-square and Paired t tests were used to analysis the data. Results: The results showed no significant difference between four groups in demographic characteristic. ANOVA results showed no significant difference between four groups in the attitude score of women before the intervention (P=0.937), but after the intervention there were significant differences between the groups (P=0.0001). Conclusion: According to the results, G. glabra consumption and exercise program were effective in controlling the symptoms of menopause attitude of menopausal woman. Therefore, it may proposed as one of the main strategies for health and education interventions. Keywords: Glycyrrhiza glabra, Exercise, Attitude, Menopause
{"title":"Effect of Glycyrrhiza glabra extract and aerobic exercise on the attitude of postmenopausal women to menopause","authors":"F. Rafiei, P. Asgari, Razieh Mokhtari, Mohamad Golitaleb","doi":"10.29252/JBRMS.4.4.1","DOIUrl":"https://doi.org/10.29252/JBRMS.4.4.1","url":null,"abstract":"Effect of Glycyrrhiza glabra extract and aerobic exercise on the attitude of postmenopausal women to menopause \u0000 \u0000Parvaneh Asgari, Fatemeh Bahramnezhad *, Mohammad Golitaleb, Fatemeh Salehi, Razieh Mokhtari, Fatemeh Rafiei \u0000 \u0000phd candidate Department of Nursing, Faculty of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran , bahramnezhad@razi.tums.ac.ir \u0000 \u0000Abstract: \u0000Introduction: Menopause is associated with complications that can affect women's attitudes. Women's attitudes toward menopause can help to improve their performance and reduce the severity of its complications. The aim of this study was to evaluate the effect of Glycyrrhiza glabra (G. glabra) plant and exercise on the attitude of menopausal women. \u0000Materials and methods: This clinical experimental fourth group was conducted between October and March 2015 in Arak, Iran. 120 menopausal women were randomly selected and divided into four groups each containing 30 women. The first group had three G. glabra tablets daily for one month, the second group had a regular exercise program three times a week for 30-45 minutes for one month and the third group simultaneously took G. glabra like Group1 and followed exercise programs like Group 2 and the fourth group received no intervention. Before and one month after the intervention attitudes of women were compared with a researcher-made questionnaire. ANOVA, Chi-square and Paired t tests were used to analysis the data. \u0000Results: The results showed no significant difference between four groups in demographic characteristic. ANOVA results showed no significant difference between four groups in the attitude score of women before the intervention (P=0.937), but after the intervention there were significant differences between the groups (P=0.0001). \u0000Conclusion: According to the results, G. glabra consumption and exercise program were effective in controlling the symptoms of menopause attitude of menopausal woman. Therefore, it may proposed as one of the main strategies for health and education interventions. \u0000 \u0000Keywords: Glycyrrhiza glabra, Exercise, Attitude, Menopause","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":" ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49555009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Rostami, H. Ayatollahi, Hassan Boustani, A. Ghotaslou, M. Sadeghian, M. Keramati, Elahe Zeinali, A. Rad, Cellular Nutrition
Introduction: PPP2R5C is one of the regulatory B subunits of protein phosphatase 2A (PP2A), which is a tumor suppressor. PPP2R5C plays a critical role in cell proliferation, differentiation, and transformation. Considering these vital functions, we investigate the gene expression in Iranian patients with B-Acute Lymphoblastic Leukemia (B-ALL) and its association with clinical and laboratory finding. Materials and methods: In this case-control study, peripheral blood samples were collected from 60 B-ALL patients and 30 healthy controls. PPP2R5C expression levels were determined by Real-time PCR. After calculation of CT for target and control genes, we calculated ΔCT. Finally we compared the PPP2R5C expression levels in patients with control group. Results: Significantly higher expression of PPP2R5C was found in the B-ALL patients (2.15±2. 50) compared with control group. There was no correlation between PPP2R5C expression and clinical and laboratory findings and FAB (French-American-British) subtype of patients. Conclusion: we demonstrated PPP2R5C overexpression in B-ALL patients. Although there was no significant correlation between PPP2R5C expression, clinical and laboratory finding and also with FAB subtypes of patients.
{"title":"Evaluation of PPP2R5C gene expression in Iranian patients with B-Acute lymphoblastic leukemia and its association with clinical and laboratory findings","authors":"E. Rostami, H. Ayatollahi, Hassan Boustani, A. Ghotaslou, M. Sadeghian, M. Keramati, Elahe Zeinali, A. Rad, Cellular Nutrition","doi":"10.29252/JBRMS.4.4.8","DOIUrl":"https://doi.org/10.29252/JBRMS.4.4.8","url":null,"abstract":"Introduction: PPP2R5C is one of the regulatory B subunits of protein phosphatase 2A (PP2A), which is a tumor suppressor. PPP2R5C plays a critical role in cell proliferation, differentiation, and transformation. Considering these vital functions, we investigate the gene expression in Iranian patients with B-Acute Lymphoblastic Leukemia (B-ALL) and its association with clinical and laboratory finding. Materials and methods: In this case-control study, peripheral blood samples were collected from 60 B-ALL patients and 30 healthy controls. PPP2R5C expression levels were determined by Real-time PCR. After calculation of CT for target and control genes, we calculated ΔCT. Finally we compared the PPP2R5C expression levels in patients with control group. Results: Significantly higher expression of PPP2R5C was found in the B-ALL patients (2.15±2. 50) compared with control group. There was no correlation between PPP2R5C expression and clinical and laboratory findings and FAB (French-American-British) subtype of patients. Conclusion: we demonstrated PPP2R5C overexpression in B-ALL patients. Although there was no significant correlation between PPP2R5C expression, clinical and laboratory finding and also with FAB subtypes of patients.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":"4 1","pages":"8-12"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42983224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Obese individuals have elevated levels of inflammatory and cell adhesion molecules that can critically induce the occurrence of atherosclerosis. Aerobic exercise training reduces biochemical markers and anthropometric characteristics involved in atherosclerosis. However, little is known about the effect of resistance exercise training on these biomarkers. This study aimed to investigate the effect of eight weeks of resistance training on atherosclerosis biochemical markers and anthropometric characteristics in obese women. Materials and methods: Fourteen obese women completed an 8-week resistance exercise training protocol with moderate intensity at 9 stations (exercise involving the major muscle groups: 3 sets of 8-15 repetitions of chest press, leg press, seated pulley rows, overhead press, seated leg press, leg curl, triceps extensions, biceps curls, and calf raises). Fasting blood samples were taken before and after the 8-week exercise training. Intercellular Adhesion Molecule1 (ICAM-1) and C-reactive protein (CRP) levels were measured using commercial kits by ELISA method. The data were analyzed using dependent t-test. Results: Resistance training significantly reduced the levels of atherosclerosis biochemical markers, ICAM-1and CRP (P=0.001). Also, body fat percentage (P=0.001), waist: hip ratio, body mass and body mass index significantly decreased following resistance training (P=0.001). However, no significant change occurred in platelet counts (P=0.922). Conclusion: Resistance training results in reduction of inflammatory biomarkers involved in atherosclerosis as well as body fat.
{"title":"Effect of resistance exercise training on biochemical markers and anthropometric characteristics involved in atherosclerosis in obese women","authors":"H. TaheriChadorneshin, Shila Neyebi-Far","doi":"10.29252/JBRMS.4.4.36","DOIUrl":"https://doi.org/10.29252/JBRMS.4.4.36","url":null,"abstract":"Introduction: Obese individuals have elevated levels of inflammatory and cell adhesion molecules that can critically induce the occurrence of atherosclerosis. Aerobic exercise training reduces biochemical markers and anthropometric characteristics involved in atherosclerosis. However, little is known about the effect of resistance exercise training on these biomarkers. This study aimed to investigate the effect of eight weeks of resistance training on atherosclerosis biochemical markers and anthropometric characteristics in obese women. Materials and methods: Fourteen obese women completed an 8-week resistance exercise training protocol with moderate intensity at 9 stations (exercise involving the major muscle groups: 3 sets of 8-15 repetitions of chest press, leg press, seated pulley rows, overhead press, seated leg press, leg curl, triceps extensions, biceps curls, and calf raises). Fasting blood samples were taken before and after the 8-week exercise training. Intercellular Adhesion Molecule1 (ICAM-1) and C-reactive protein (CRP) levels were measured using commercial kits by ELISA method. The data were analyzed using dependent t-test. Results: Resistance training significantly reduced the levels of atherosclerosis biochemical markers, ICAM-1and CRP (P=0.001). Also, body fat percentage (P=0.001), waist: hip ratio, body mass and body mass index significantly decreased following resistance training (P=0.001). However, no significant change occurred in platelet counts (P=0.922). Conclusion: Resistance training results in reduction of inflammatory biomarkers involved in atherosclerosis as well as body fat.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":"4 1","pages":"36-43"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42110331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Intellectual disability or intellectual retardation is a condition in which total mental functioning is distinctively below average and there are disabilities in adaptive behaviors during growth. According to the definition of American Mental Disability Community in 1992 a person is considered intellectually disabled if he or she has an IQ (intelligence quotient) of less than 70 and has a limitation in one or multiple adaptive skills. There are many different causes of intellectual disability that one of them is the genetically and chromosomal abnormalities. The aim of this paper was to study translocation breakout t (1; 4) (p21; p14) in a number of mental retardation patients in Iran. Materials and methods: This descriptive study was carried out on 100 persons with light mental disability by using cytogenetic methods. Lymphocytes were cultured in the dedicated environment by G-Banding karyotype of each person after obtaining patient’s blood sample. The data were statistically analyzed by logistic regression. Results: The findings showed that none of the patients with a mental disability was afflicted to the chromosomal translocation, (1; 4) (p21; p14). Conclusion: The lack of translocation in this study was equivalent with the obtained frequency in the same studies which have been carried out on the subjects suspected to have a translocation. Also, it seems that chromosomal analysis may be a usefulness diagnostic tool for children with mental retardation.
{"title":"The prevalence of chromosomal translocation t (1; 4) (p21; p14) in Iranian patients with mental disability","authors":"P. Vosoughi, F. Keshavarzi, P. Ashtari","doi":"10.29252/JBRMS.4.4.13","DOIUrl":"https://doi.org/10.29252/JBRMS.4.4.13","url":null,"abstract":"Introduction: Intellectual disability or intellectual retardation is a condition in which total mental functioning is distinctively below average and there are disabilities in adaptive behaviors during growth. According to the definition of American Mental Disability Community in 1992 a person is considered intellectually disabled if he or she has an IQ (intelligence quotient) of less than 70 and has a limitation in one or multiple adaptive skills. There are many different causes of intellectual disability that one of them is the genetically and chromosomal abnormalities. The aim of this paper was to study translocation breakout t (1; 4) (p21; p14) in a number of mental retardation patients in Iran. Materials and methods: This descriptive study was carried out on 100 persons with light mental disability by using cytogenetic methods. Lymphocytes were cultured in the dedicated environment by G-Banding karyotype of each person after obtaining patient’s blood sample. The data were statistically analyzed by logistic regression. Results: The findings showed that none of the patients with a mental disability was afflicted to the chromosomal translocation, (1; 4) (p21; p14). Conclusion: The lack of translocation in this study was equivalent with the obtained frequency in the same studies which have been carried out on the subjects suspected to have a translocation. Also, it seems that chromosomal analysis may be a usefulness diagnostic tool for children with mental retardation.","PeriodicalId":15047,"journal":{"name":"Journal of Basic Research in Medical Sciences","volume":"4 1","pages":"13-17"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46929343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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