Pub Date : 2020-02-29DOI: 10.1097/jbr.0000000000000064
L. Cai, Yiran Bao, Lin He
{"title":"Less over-prevention, more positive mentality","authors":"L. Cai, Yiran Bao, Lin He","doi":"10.1097/jbr.0000000000000064","DOIUrl":"https://doi.org/10.1097/jbr.0000000000000064","url":null,"abstract":"","PeriodicalId":150904,"journal":{"name":"Journal of Bio-X Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132790015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-01DOI: 10.1097/jbr.0000000000000046
Minglong Cai, Delin Ran, Xuejun Zhang
{"title":"Advances in identifying coding variants of common complex diseases","authors":"Minglong Cai, Delin Ran, Xuejun Zhang","doi":"10.1097/jbr.0000000000000046","DOIUrl":"https://doi.org/10.1097/jbr.0000000000000046","url":null,"abstract":"","PeriodicalId":150904,"journal":{"name":"Journal of Bio-X Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125823039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.1097/jbr.0000000000000045
Sujing Jiang, Xufeng Han, Daye Dong, R. Zhao, Lulu Ren, Zhen Liu, Xinmei Yang, Hao Liu, Ying Dong, W. Han
{"title":"Prognostic value of negative lymph node count in patients with jejunoileal neuroendocrine tumors","authors":"Sujing Jiang, Xufeng Han, Daye Dong, R. Zhao, Lulu Ren, Zhen Liu, Xinmei Yang, Hao Liu, Ying Dong, W. Han","doi":"10.1097/jbr.0000000000000045","DOIUrl":"https://doi.org/10.1097/jbr.0000000000000045","url":null,"abstract":"","PeriodicalId":150904,"journal":{"name":"Journal of Bio-X Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128746706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.1097/JBR.0000000000000039
Fengwen Tang, Xiaoling Chen, L. Jia, Hai Li, Jingya Li, W. Yuan
{"title":"Zinc-finger protein A20 protects hair cells from damage made by high-power microwave","authors":"Fengwen Tang, Xiaoling Chen, L. Jia, Hai Li, Jingya Li, W. Yuan","doi":"10.1097/JBR.0000000000000039","DOIUrl":"https://doi.org/10.1097/JBR.0000000000000039","url":null,"abstract":"","PeriodicalId":150904,"journal":{"name":"Journal of Bio-X Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125456709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.1097/jbr.0000000000000043
Xiaoyi Fu, Hongyan Wang, Xiaojin Zhang
{"title":"Genetic aspects of early menopause","authors":"Xiaoyi Fu, Hongyan Wang, Xiaojin Zhang","doi":"10.1097/jbr.0000000000000043","DOIUrl":"https://doi.org/10.1097/jbr.0000000000000043","url":null,"abstract":"","PeriodicalId":150904,"journal":{"name":"Journal of Bio-X Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114211481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.1097/JBR.0000000000000042
Zhixuan Chen, Chuanxin Liu, Lin An, Naixin Zhang, Decheng Ren, Fan Yuan, Ruixue Yuan, Yan Bi, Qianqian Sun, Lei Ji, Zhenming Guo, Gaini Ma, Fei Xu, Lei Shi, Feng-ping Yang, L. Du, Liping Zhu, Yifeng Xu, Lin He, Bo Bai, T. Yu, Xing-wang Li, G. He
{"title":"Single nucleotide polymorphism rs11191454 in arsenite methyltransferase is associated with flow in Chinese students: a genetic study on flow experience","authors":"Zhixuan Chen, Chuanxin Liu, Lin An, Naixin Zhang, Decheng Ren, Fan Yuan, Ruixue Yuan, Yan Bi, Qianqian Sun, Lei Ji, Zhenming Guo, Gaini Ma, Fei Xu, Lei Shi, Feng-ping Yang, L. Du, Liping Zhu, Yifeng Xu, Lin He, Bo Bai, T. Yu, Xing-wang Li, G. He","doi":"10.1097/JBR.0000000000000042","DOIUrl":"https://doi.org/10.1097/JBR.0000000000000042","url":null,"abstract":"","PeriodicalId":150904,"journal":{"name":"Journal of Bio-X Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114493696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.1097/JBR.0000000000000032
Xiaoyu Yu, Hao Wu, Tao Yang
{"title":"Molecular basis of hearing loss associated with enlarged vestibular aqueduct","authors":"Xiaoyu Yu, Hao Wu, Tao Yang","doi":"10.1097/JBR.0000000000000032","DOIUrl":"https://doi.org/10.1097/JBR.0000000000000032","url":null,"abstract":"","PeriodicalId":150904,"journal":{"name":"Journal of Bio-X Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121930453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.1097/jbr.0000000000000044
Jinping Gao, Caihong Zhu, Zhengwei Zhu, Lili Tang, Lu Liu, L. Wen, Liangdan Sun
{"title":"The human leukocyte antigen and genetic susceptibility in human diseases","authors":"Jinping Gao, Caihong Zhu, Zhengwei Zhu, Lili Tang, Lu Liu, L. Wen, Liangdan Sun","doi":"10.1097/jbr.0000000000000044","DOIUrl":"https://doi.org/10.1097/jbr.0000000000000044","url":null,"abstract":"","PeriodicalId":150904,"journal":{"name":"Journal of Bio-X Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122099131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-01DOI: 10.1097/JBR.0000000000000035
Diyan Chen, Gaogan Jia, Yusu Ni, Yan Chen
Hidden hearing loss (HHL), an auditory dysfunction that has gained much recent attention, has the hallmarks of speech discrimination and intelligibility deficits with normal or near-normal hearing thresholds. The pathological mechanisms of HHL are complicated and are not yet fully understood. HHL can be resulted from disorders of the central nervous system such as auditory cortex, and/or pathological changes of inner ear. Thus far, 2 pathological phenomena, synaptopathy and auditory nerve demyelination, have been reported as underlying causes of otogenic HHL. Here, we review the clinical and physiological characteristics of HHL as well as the molecular pathological mechanisms of otogenic HHL and aim to allude to potential therapy targets for clinical applications in the future. Key words: auditory; cochlear hair cells; demyelination; hearing loss; hidden hearing loss; Schwann cells; spiral ganglion neurons; synapse; synaptopathy
{"title":"Hidden hearing loss: current perspectives and potential therapies","authors":"Diyan Chen, Gaogan Jia, Yusu Ni, Yan Chen","doi":"10.1097/JBR.0000000000000035","DOIUrl":"https://doi.org/10.1097/JBR.0000000000000035","url":null,"abstract":"Hidden hearing loss (HHL), an auditory dysfunction that has gained much recent attention, has the hallmarks of speech discrimination and intelligibility deficits with normal or near-normal hearing thresholds. The pathological mechanisms of HHL are complicated and are not yet fully understood. HHL can be resulted from disorders of the central nervous system such as auditory cortex, and/or pathological changes of inner ear. Thus far, 2 pathological phenomena, synaptopathy and auditory nerve demyelination, have been reported as underlying causes of otogenic HHL. Here, we review the clinical and physiological characteristics of HHL as well as the molecular pathological mechanisms of otogenic HHL and aim to allude to potential therapy targets for clinical applications in the future. \u0000 \u0000 \u0000Key words: \u0000auditory; cochlear hair cells; demyelination; hearing loss; hidden hearing loss; Schwann cells; spiral ganglion neurons; synapse; synaptopathy","PeriodicalId":150904,"journal":{"name":"Journal of Bio-X Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130374997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-01DOI: 10.1097/JBR.0000000000000033
Jiping Wang, Zheng Yan, Y. Xing, Ke Lai, Jian Wang, Dongzhen Yu, Haibo Shi, Shankai Yin
Zebrafish have the potential to regrow injured organs and tissues, but their use as a model for hearing regeneration following blast injury has never been reported. In this study, zebrafish were exposed to a blast wave produced by an underwater blast wave generator. The first peak sound pressures produced by this generator were up to 224 dB and 160kPa, measured at 25 cm away from the machine. Zebrafish hearing sensitivity was examined by analyzing auditory evoked potentials from 1 to 35 days post blast wave exposure. Cell death and cell proliferation in inner ear organs, including the saccule, lagena, and utricle, were investigated using a terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling assay, and cell proliferation assay using 5-ethynyl-2＇-deoxyuridine, respectively. Significant differences in auditory evoked potential thresholds were observed between exposed and control groups, demonstrating both blast wave-induced hearing loss and recovery of hearing sensitivity. An apoptosis assay revealed significantly increased numbers of terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling- positive cells in the inner ear sensory epithelia of exposed groups compared with the control group. However, numbers of 5-ethynyl- 2＇-deoxyuridine-positive cells in the inner ear of exposed groups recovered to a normal level within 10 post blast wave exposure. Furthermore, blast wave exposure caused brain injury with increased cell apoptosis and decreased neurogenesis. Compared with drug or noise-induced zebrafish models, our blast wave-induced model elicited more serious hearing loss phenotypes, which required more time to return to a normal level. Overall, this zebrafish model can provide a reliable animal model for both hearing loss and regeneration research. The study was approved by the Shanghai 6th Hospital Animal Care and Use Committee, China (approval No. 2017-0196) on February 28, 2017. Key words: blast wave; zebrafish; hearing loss; brain injury; auditory evoked potential; hair cell; apoptosis; regeneration
{"title":"A zebrafish model for hearing loss and regeneration induced by blast wave","authors":"Jiping Wang, Zheng Yan, Y. Xing, Ke Lai, Jian Wang, Dongzhen Yu, Haibo Shi, Shankai Yin","doi":"10.1097/JBR.0000000000000033","DOIUrl":"https://doi.org/10.1097/JBR.0000000000000033","url":null,"abstract":"Zebrafish have the potential to regrow injured organs and tissues, but their use as a model for hearing regeneration following blast injury has never been reported. In this study, zebrafish were exposed to a blast wave produced by an underwater blast wave generator. The first peak sound pressures produced by this generator were up to 224 dB and 160kPa, measured at 25 cm away from the machine. Zebrafish hearing sensitivity was examined by analyzing auditory evoked potentials from 1 to 35 days post blast wave exposure. Cell death and cell proliferation in inner ear organs, including the saccule, lagena, and utricle, were investigated using a terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling assay, and cell proliferation assay using 5-ethynyl-2＇-deoxyuridine, respectively. Significant differences in auditory evoked potential thresholds were observed between exposed and control groups, demonstrating both blast wave-induced hearing loss and recovery of hearing sensitivity. An apoptosis assay revealed significantly increased numbers of terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling- positive cells in the inner ear sensory epithelia of exposed groups compared with the control group. However, numbers of 5-ethynyl- 2＇-deoxyuridine-positive cells in the inner ear of exposed groups recovered to a normal level within 10 post blast wave exposure. Furthermore, blast wave exposure caused brain injury with increased cell apoptosis and decreased neurogenesis. Compared with drug or noise-induced zebrafish models, our blast wave-induced model elicited more serious hearing loss phenotypes, which required more time to return to a normal level. Overall, this zebrafish model can provide a reliable animal model for both hearing loss and regeneration research. The study was approved by the Shanghai 6th Hospital Animal Care and Use Committee, China (approval No. 2017-0196) on February 28, 2017. \u0000 \u0000 \u0000Key words: \u0000blast wave; zebrafish; hearing loss; brain injury; auditory evoked potential; hair cell; apoptosis; regeneration","PeriodicalId":150904,"journal":{"name":"Journal of Bio-X Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134311703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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