Pub Date : 2018-06-01DOI: 10.1097/JBR.0000000000000004
Yandan Yao, B. Dong, Wei Wu, Quan Li, Yang Chen, Baiji Chen, Y. Jiang, Mingxia Zhang, Shi Liang, Yonghua Li, Songyin Huang
Abstract This study aimed to describe the clinicopathologic characteristics of non-puerperal mastitis and to investigate spectrum of organisms causing it in the population of Southern China. We retrospectively registered 364 female patients with histological confirmation of inflammatory disease of the breast in the non-lactational phase, who were admitted to our institution over an 11-year period (2005–2016). Clinical, laboratory, and radiographic imaging features, as well as their bacteriological etiology, were analyzed in detail. In this study, 117 patients were diagnosed with periductal mastitis (PDM)/mammary duct ectasia (MDE) and 247 patients were diagnosed with idiopathic granulomatous mastitis (IGM). There were significant differences in terms of mean age of onset, menstruation period, and menstruation history. Nipple discharge, inverted nipple, and the ratio of abscess and fistula were more spontaneous in women with PDM/MDE compared to IGM. The inflammatory biomarkers including leukocyte count, neutrophil percentage, and high-sensitivity C-reactive protein in PDM/MDE group were significantly higher than IGM group. For bacteriological etiology, the most commonly isolated organism was Corynebacterium kroppenstedtii (C kroppenstedtii) in the IGM group and Staphylococcus in the PDM/MDE group. The study shows that the combination of demographic characteristics and clinicopathological characteristics was helpful in differential diagnosis of PDM/MDE and IGM. IGM can be associated with C kroppenstedtii, providing a possible effective therapeutic and preventive method by targeting this kind of bacilli.
{"title":"Clinicodiagnostic management and bacteriological etiology of non-puerperal mastitis in the population of Southern China","authors":"Yandan Yao, B. Dong, Wei Wu, Quan Li, Yang Chen, Baiji Chen, Y. Jiang, Mingxia Zhang, Shi Liang, Yonghua Li, Songyin Huang","doi":"10.1097/JBR.0000000000000004","DOIUrl":"https://doi.org/10.1097/JBR.0000000000000004","url":null,"abstract":"Abstract This study aimed to describe the clinicopathologic characteristics of non-puerperal mastitis and to investigate spectrum of organisms causing it in the population of Southern China. We retrospectively registered 364 female patients with histological confirmation of inflammatory disease of the breast in the non-lactational phase, who were admitted to our institution over an 11-year period (2005–2016). Clinical, laboratory, and radiographic imaging features, as well as their bacteriological etiology, were analyzed in detail. In this study, 117 patients were diagnosed with periductal mastitis (PDM)/mammary duct ectasia (MDE) and 247 patients were diagnosed with idiopathic granulomatous mastitis (IGM). There were significant differences in terms of mean age of onset, menstruation period, and menstruation history. Nipple discharge, inverted nipple, and the ratio of abscess and fistula were more spontaneous in women with PDM/MDE compared to IGM. The inflammatory biomarkers including leukocyte count, neutrophil percentage, and high-sensitivity C-reactive protein in PDM/MDE group were significantly higher than IGM group. For bacteriological etiology, the most commonly isolated organism was Corynebacterium kroppenstedtii (C kroppenstedtii) in the IGM group and Staphylococcus in the PDM/MDE group. The study shows that the combination of demographic characteristics and clinicopathological characteristics was helpful in differential diagnosis of PDM/MDE and IGM. IGM can be associated with C kroppenstedtii, providing a possible effective therapeutic and preventive method by targeting this kind of bacilli.","PeriodicalId":150904,"journal":{"name":"Journal of Bio-X Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126314351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-01DOI: 10.1097/JBR.0000000000000006
Qionghua Cui, Chen Wu, D. Lin
Human cancer is a complex disease caused by the interaction of multiple genes and environmental factors. It is known that environmental factors such as smoking, drinking, and food carcinogens are implicated in the development of certain types of cancer including esophageal squamous cell carcinoma (ESCC). However, only a small portion of exposed individuals finally developed cancer, indicating that genetic makeup also plays an important role in the tumorigenesis. Genome-wide association studies (GWAS) have found numerous susceptible genes or loci for cancers, providing new ideas and directions for precision prevention and treatment of cancers. With the advances in the field of next-generation sequencing (NGS), the genomic landscapes of many types of human cancer have comprehensively been characterized. Here, we review the progresses of GWAS and NGS in revealing genomic variations of ESCC, one of the most common cancers in China, and discuss the potential applications of these results in precision medicine of ESCC. Key words: esophageal cancer; genomic alteration; precise medicine
{"title":"Genomic alterations and precise medicine of esophageal squamous cell carcinoma","authors":"Qionghua Cui, Chen Wu, D. Lin","doi":"10.1097/JBR.0000000000000006","DOIUrl":"https://doi.org/10.1097/JBR.0000000000000006","url":null,"abstract":"Human cancer is a complex disease caused by the interaction of multiple genes and environmental factors. It is known that environmental factors such as smoking, drinking, and food carcinogens are implicated in the development of certain types of cancer including esophageal squamous cell carcinoma (ESCC). However, only a small portion of exposed individuals finally developed cancer, indicating that genetic makeup also plays an important role in the tumorigenesis. Genome-wide association studies (GWAS) have found numerous susceptible genes or loci for cancers, providing new ideas and directions for precision prevention and treatment of cancers. With the advances in the field of next-generation sequencing (NGS), the genomic landscapes of many types of human cancer have comprehensively been characterized. Here, we review the progresses of GWAS and NGS in revealing genomic variations of ESCC, one of the most common cancers in China, and discuss the potential applications of these results in precision medicine of ESCC. \u0000 \u0000 \u0000Key words: \u0000esophageal cancer; genomic alteration; precise medicine","PeriodicalId":150904,"journal":{"name":"Journal of Bio-X Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121938861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-01DOI: 10.1097/JBR.0000000000000005
Lin He
{"title":"Welcome to Journal of Bio-X Research","authors":"Lin He","doi":"10.1097/JBR.0000000000000005","DOIUrl":"https://doi.org/10.1097/JBR.0000000000000005","url":null,"abstract":"","PeriodicalId":150904,"journal":{"name":"Journal of Bio-X Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128002259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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