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Observations on the Migration of Bacillus Spores Outside a Contaminated Facility During a Decontamination Efficacy Study 在净化效果研究中对污染设施外芽孢杆菌孢子迁移的观察
Pub Date : 2015-05-06 DOI: 10.4172/2157-2526.1000135
E. Silvestri, Sarah D. Perkins, R. Lordo, W. Kovacik, T. Nichols, Charlena Yoder Bowling, D. Griffin, F. Schaefer
The fate and transport of Bacillus anthracis spores in indoor and outdoor environments is not well understood. The Bio-Response Operational Testing and Evaluation exercise evaluated decontamination technologies in a twostory building experimentally contaminated with Bacillus atrophaeus subspecies globigii spores. The Bio-Response Operational Testing and Evaluation project provided a means to evaluate the potential for the spores dispersed inside the building to migrate to the outside as well as to investigate a new method for processing soils contaminated with Bacillus spores. Duplicate sterile sand samples were placed within the tent covering the building, but outside the building itself, near entrances, exits, and high-traffic areas to assess migration and deposition of newly disseminated spores. The sand samples were utilized during three stages of the decontamination study: before spore dissemination, after spore dissemination, and after decontamination of the building. In addition, two sets of sand samples placed within the building provided positive controls. Results from two different building decontamination approaches were studied. Results were tabulated as presence or absence rather than as a quantitative figure. There was no significant association among positive samples and the location of the samples around the building. There was a significant association between the different stages of each decontamination study and the number of detectable samples. The results of this study demonstrate the potential for spores to migrate out of a contaminated building and the importance of considering migration when assessing the scope of a contamination incident
炭疽芽孢杆菌孢子在室内和室外环境中的命运和运输尚不清楚。生物反应操作测试和评估活动评估了一幢被萎缩芽孢杆菌亚种球形芽孢实验性污染的两层建筑的净化技术。生物反应操作测试和评估项目提供了一种方法来评估分散在建筑物内的孢子迁移到外部的可能性,并研究处理被芽孢杆菌孢子污染的土壤的新方法。重复的无菌沙样本放置在覆盖建筑物的帐篷内,但在建筑物外,靠近入口,出口和高交通区域,以评估新传播孢子的迁移和沉积。砂样在去污研究的三个阶段使用:孢子传播前、孢子传播后和建筑物去污后。此外,放置在建筑物内的两组沙子样本提供了积极的控制。研究了两种不同的建筑物净化方法的效果。结果以存在或不存在的形式制成表格,而不是作为一个定量数字。阳性样本与样本在建筑物周围的位置之间没有显著的关联。每个净化研究的不同阶段与可检测样本的数量之间存在显著关联。这项研究的结果证明了孢子有可能从受污染的建筑物中迁移出来,以及在评估污染事件的范围时考虑迁移的重要性
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引用次数: 4
Threats of Agricultural Bioterrorism to an Agro Dependent Economy; What Should be Done? 农业生物恐怖主义对农业依赖型经济的威胁应该做些什么?
Pub Date : 2015-05-06 DOI: 10.4172/2157-2526.1000127
A. Khalil, Z. Shinwari
The economy of Pakistan is primarily dependent on its agricultural resources. Due to the lack of research regarding threat analysis of germ warfare in Pakistan, it is imperative for the agriculturists to understand the potential hazards associated with an attack on the cash crops that contributes heavily to the overall Gross Domestic Product (GDP) growth. Alarming terrorist activities such as 9/11 and many innovative terrorist strategies like Improved Explosive Devices (IED) in different countries, especially in Pakistan, has increased the potential of bioterrorism. Hence there is urgent need of security risk analysis and preparedness. State of the art research labs are not important for the effective production of biological weapons but certainly innovative strategies are required to effectively implement and counter a bioterrorist plan. Bioweapon infection to some staple crops such as wheat and maize can induce a significant loss that can take years to diffuse. This paper is concerned with the vulnerability of certain important crops in Pakistan that can be exposed as soft targets to certain bioterrorists and discusses the preemptive measures that should be undertaken immediately to prevent any sort of nefarious act of bioterrorism.
巴基斯坦的经济主要依赖于农业资源。由于缺乏对巴基斯坦细菌战威胁分析的研究,农民必须了解对经济作物的攻击所带来的潜在危害,而经济作物对整体国内生产总值(GDP)的增长贡献很大。令人震惊的恐怖主义活动,如9/11和许多创新的恐怖主义战略,如改进的爆炸装置(IED),在不同的国家,特别是在巴基斯坦,增加了生物恐怖主义的潜力。因此,迫切需要进行安全风险分析和防范。最先进的研究实验室对于有效生产生物武器并不重要,但要有效实施和应对生物恐怖主义计划,肯定需要创新的战略。生物武器感染一些主要作物,如小麦和玉米,可造成重大损失,可能需要数年时间才能扩散。本文关注巴基斯坦某些重要作物的脆弱性,这些作物可能成为某些生物恐怖分子的软目标,并讨论应立即采取的先发制人措施,以防止任何形式的生物恐怖主义邪恶行为。
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引用次数: 12
New Atypical Influenza: Possible Trend for Bioterrorism 新型非典型流感:生物恐怖主义的可能趋势
Pub Date : 2015-04-08 DOI: 10.4172/2157-2526.1000E119
V. Wiwanitkit
Atypical influenza is the present global consideration. Within the few years, many new atypical influenza infections emerge around the world and become the important public health issue. The possible trend for bioterrorism of the new influenza is hereby discussed.
非典型流感是目前全球关注的问题。几年内,世界各地出现了许多新的非典型流感感染,并成为重要的公共卫生问题。并对新型流感生物恐怖主义的可能趋势进行了讨论。
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引用次数: 2
Quantitative Decision Tools for the Management and Analysis of the Risk from Terrorist Attacks 恐怖袭击风险管理与分析的定量决策工具
Pub Date : 2015-03-27 DOI: 10.4172/2157-2526.1000134
E. Melnick
A natural epidemic is a disease that suddenly affects many individuals in a short time period, spreading from person to person in a locality where thedisease is not usually prevalent. The sudden outbreak of an epidemic is usually modeled as a random variable because it cannot be anticipated. Epidemics introduced by bioterrorists are planned events by intelligent adversaries, who might also introduce other terrorists’ activities that dependon the responses of the defenders. Since these events are not random, models maybe helpful for anticipating terrorist attacks. Since defendingagainst such attacks does not fit into the classical modeling paradigmbecause there is a scarcity of data, the defender must respond quickly, the attacker can also adapt new strategies in response to the actions of thedefender, new modeling strategies are required to improve the strategies of the defender. In this article, a Stackelberg model combined with fault trees is proposed for determining sequential optimal defense strategies for thedefender by identifying minimal cut sets of events that would most likely lead to a successful terrorist attack. Further, if the model can be formulated as a sequence of Markovian state changes based on default trees, a dynamic programming problem with the Bellman equation reduces the solution from evaluating a complex model to evaluating a sequence of simple problems
自然流行病是一种疾病,在短时间内突然影响到许多人,在通常不流行的地方在人与人之间传播。流行病的突然爆发通常被建模为随机变量,因为它无法预测。生物恐怖分子引起的流行病是由聪明的对手策划的事件,他们也可能引入其他恐怖分子的活动,这些活动取决于防御者的反应。由于这些事件不是随机的,模型可能有助于预测恐怖袭击。由于数据稀缺,防御这种攻击不符合经典的建模范式,防御者必须快速响应,攻击者也可以适应新的策略来响应防御者的行动,新的建模策略需要改进防御者的策略。在本文中,提出了一个Stackelberg模型与故障树相结合,通过识别最有可能导致成功恐怖袭击的最小事件集,为防御者确定顺序最优防御策略。此外,如果模型可以表示为基于默认树的马尔可夫状态变化序列,则具有Bellman方程的动态规划问题将解决方案从评估复杂模型减少到评估一系列简单问题
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引用次数: 0
Emerging Zoonotic Diseases: Can it be the Case of Bioterrorism 新出现的人畜共患疾病:会是生物恐怖主义吗
Pub Date : 2015-03-14 DOI: 10.4172/2157-2526.S14-E101
V. Wiwanitkit
Within the past decade, there are several new emerging zoonotic diseases (such as H5N1 bird flu). Those new emerging zoonotic diseases become the important issue for medical society. Since the disease is new and cross species, the diagnosis and management of the new emerging zoonotic disease is usually difficulty. In general situation, attempting to control of new disease needs a great effort. However, in a more complex situation, the bioterrorism, the situation can be worse [1].
在过去十年中,出现了几种新的人畜共患疾病(如H5N1禽流感)。这些新出现的人畜共患疾病已成为医学界关注的重要问题。由于该病是一种新的跨物种疾病,新出现的人畜共患疾病的诊断和管理通常是困难的。一般情况下,控制新疾病需要付出很大的努力。然而,在更复杂的情况下,生物恐怖主义,情况可能会更糟。
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引用次数: 5
Pakistans Bio-Preparedness With Regard To Biosecurity, Biodefense Strategies and Policy Measures 巴基斯坦在生物安全、生物防御战略和政策措施方面的生物准备
Pub Date : 2015-01-27 DOI: 10.4172/2157-2526.1000132
A. Khalil, Faouzia Tanveer, Z. Shinwari
Bioterror threats worldwide call for significant security measures such as legal reforms to ensure preparedness to the possible use of biological materials as deadly weapons. Pakistan as a terrorism stricken nation is already confronted with threats from various terrorist groups thus possibility of bio-terrorism in the country in near future cannot be denied. This review focuses on possible bio-threats to the country, existing policy frameworks by the government of Pakistan and national bodies or organizations working for the cause of biosecurity in the country. It also emphasizes the need to establish effective strategies related to bio-defense for country’s preparedness to the threats posed by potential bio-weapons. The review concludes that in addition to development of strong bioresponse mechanisms, important steps must be taken in terms of bio-defense related R&D, capacity building and policy measures.
世界范围内的生物恐怖威胁要求采取重大安全措施,如法律改革,以确保对可能使用生物材料作为致命武器做好准备。巴基斯坦作为一个受恐怖主义影响的国家,已经面临着各种恐怖组织的威胁,因此在不久的将来该国发生生物恐怖主义的可能性是不可否认的。这篇综述的重点是该国可能面临的生物威胁、巴基斯坦政府和致力于该国生物安全事业的国家机构或组织的现有政策框架。它还强调需要制定与生物防御有关的有效战略,以便各国准备应对潜在生物武器构成的威胁。该综述认为,除了建立强大的生物反应机制外,还必须在生物防御相关的研发、能力建设和政策措施方面采取重要步骤。
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引用次数: 3
Institutional Review of Dual Use Research of Concern to Support a Culture of Responsibility 关注双重用途研究以支持责任文化的机构审查
Pub Date : 2015-01-06 DOI: 10.4172/2157-2526.1000130
P. Landon, N. Bergman, J. S. Goodrich, J. Osborn, J. PatrickFitch
The National Biodefense Analysis and Countermeasures Center (NBACC) plays a central role in the US Biodefense community, and its unique mission has driven NBACC to make dual use research of concern (DURC) review a focus since inception. Review of research results prior to external release began in 2007 and an institution-level review of all projects that considers DURC was implemented beginning in 2011. The DURC review process at NBACC has evolved through four approaches—each with advantages and disadvantages—that are all consistent with the recently issued U.S. Government Policy for Institutional Oversight of Life Sciences Dual Use Research of Concern. The current NBACC review process emphasizes Principal Investigator (PI) ownership and accountability, builds transparency in DURC review, and is specifically tailored to NBACC in order to reinforce an institutional culture of responsibility. This paper summarizes NBACC’s evolutionary process for effective DURC review.
美国国家生物防御分析与对策中心(NBACC)在美国生物防御界发挥着核心作用,其独特的使命促使NBACC自成立以来一直将双重用途研究(DURC)审查作为重点。2007年开始对外发布研究成果之前的审查,2011年开始对所有考虑DURC的项目进行机构级审查。NBACC的DURC审查过程经过了四种方法的演变,每种方法都有优点和缺点,这些方法都与最近发布的美国政府生命科学双重用途研究机构监督政策相一致。目前的NBACC审查过程强调主要研究者(PI)的所有权和责任,在DURC审查中建立透明度,并专门为NBACC量身定制,以加强责任的机构文化。本文总结了NBACC对DURC有效审查的演变过程。
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引用次数: 1
Untimely Intake a Postmodern Public Health Bioterrorism 不合时宜地接受后现代公共卫生生物恐怖主义
Pub Date : 2015-01-02 DOI: 10.4172/2157-2526.1000E118
A. Nikkhah
Volume 6 • Issue 3 • 1000e118 J Bioterror Biodef ISSN:2157-2526 JBTBD an open access journal The objective of this editorial article is to raise a postmodern concern on public health programs as for untimely intake of concentrated foods. This communication also warns the public health policy-makers and medical-nutritional programmers of inadequate education on timely food intake as an effective biodefense strategy.
J Bioterror Biodef ISSN:2157-2526 JBTBD一份开放获取期刊这篇社论的目的是提出后现代对公共卫生计划的关注,因为不及时摄入浓缩食物。本通讯还警告公共卫生决策者和医疗营养规划人员,关于及时摄入食物作为有效生物防御策略的教育不足。
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引用次数: 12
Up-Converting Phosphor Technology-based lateral-flow Assay: Plague Surveillance Method Particularly for Decomposed Viscera 基于上转换荧光粉技术的横向流动试验:鼠疫监测方法,特别是对腐烂的脏器
Pub Date : 2015-01-01 DOI: 10.4172/2157-2526.1000136
Pingping Zhang, Fei Hua, Xiaotao Yu
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引用次数: 2
Low Level of Awareness in Biosafety and Biosecurity among Professionals in Uganda: A Potential Risk in the Dual-Use Dilemma 乌干达专业人员对生物安全和生物安全的认识水平低:双重用途困境中的潜在风险
Pub Date : 2015-01-01 DOI: 10.4172/2157-2526.1000128
H. Kirunda, Maxwell Otim-Onapa
Disease diagnosis, and analysis or manipulation of both human and animal samples, expose scientists and practitioners to disease causing agents and toxins. In situations of poor awareness of biosecurity, the same samples can easily be accessed by persons with wrong intentions or misused by the same scientists or practitioners (dualuse). In Uganda information required to minimize the global challenges of biosafety and biosecurity has been largely lacking. The current study assessed the level of awareness and existence of procedures, regulations, laws and policies on biosafety and biosecurity among institutions in the different sectors, professions and regions across the country. Results showed that sector, profession and region were each a predictor for nine of the assessed variables. Among the most striking was that profession significantly influenced (χ2=49.0) the opinion that institutional measures to prevent or prohibit production, stockpiling, retention or unimpeded access to pathogenic agents and biological toxins existed. Professionals (veterinary scientists and laboratory technologists) in animal health research had reduced odds of holding this opinion (OR=0.2, 95% CI: 0.05-0.87) compared to their counterparts in public hygiene. Scientific establishments in eastern (OR=0.3, 95% CI: 0.17-0.7, p<0.01), northern (OR=0.4, 95% CI: 0.17-0.71, p<0.01) and western (OR=0.3, 95% CI: 0.16-0.51, p<0.01) regions were less associated with professionals trained in biosafety and biosecurity compared to central Uganda. Professionals in wildlife conservation, medical, human health research, public hygiene and crop extension services were 9.5, 7.0, 5.7, 5.4 and 4.0 times, respectively, more likely to consider Uganda’s disease monitoring system as adequate compared to those in veterinary services sector. We conclude that there is inadequate level of awareness on laboratory biosafety and biosecurity among professionals in the country. There is need for raising awareness and training of relevant professionals and formulation of measures, policies, regulations and laws to help prevent exposure to and misuse of dangerous biological agents and toxins in Uganda.
疾病诊断以及对人类和动物样本的分析或操作,使科学家和从业人员暴露于致病剂和毒素之下。在生物安全意识不佳的情况下,同样的样品很容易被有错误意图的人获取或被同一科学家或从业者滥用(双重使用)。在乌干达,最大限度地减少生物安全和生物保障的全球挑战所需的信息在很大程度上缺乏。目前的研究评估了全国不同部门、专业和地区的机构对生物安全和生物安全的程序、法规、法律和政策的认识水平和存在程度。结果显示,行业、专业和地区分别是9个评估变量的预测因子。其中最引人注目的是,职业显著影响(χ2=49.0)防止或禁止生产、储存、保留或不受阻碍地获得病原体和生物毒素的体制措施存在的观点。与公共卫生领域的同行相比,从事动物卫生研究的专业人员(兽医科学家和实验室技术人员)持有这种观点的几率较低(OR=0.2, 95% CI: 0.05-0.87)。与乌干达中部地区相比,东部地区(OR=0.3, 95% CI: 0.17-0.7, p<0.01)、北部地区(OR=0.4, 95% CI: 0.17-0.71, p<0.01)和西部地区(OR=0.3, 95% CI: 0.16-0.51, p<0.01)的科研机构与受过生物安全和生物安保培训的专业人员的关系较差。野生动物保护、医学、人类健康研究、公共卫生和作物推广服务领域的专业人员分别为9.5、7.0、5.7、5.4和4.0倍,与兽医服务部门的专业人员相比,他们更有可能认为乌干达的疾病监测系统是适当的。我们的结论是,该国专业人员对实验室生物安全和生物安全的认识水平不足。有必要提高有关专业人员的认识和培训,并制订措施、政策、条例和法律,以帮助防止乌干达境内危险生物剂和毒素的接触和滥用。
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引用次数: 7
期刊
Journal of Bioterrorism and Biodefense
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