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Corrigendum to "Comparison of pilot tone-triggered and electrocardiogram-triggered cardiac magnetic resonance imaging: a prospective clinical feasibility study" [J Cardiovasc Magn Reson 27 (2025) 101925]. 心电磁共振成像技术的应用[J].中华心血管病杂志,2002,10(1):1 - 2。
IF 6.1 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-12-01 Epub Date: 2025-11-19 DOI: 10.1016/j.jocmr.2025.101941
Xianling Qian, Yali Wu, Peter Speier, Caixia Fu, Yunzhu Wu, Lude Cheng, Yinyin Chen, Shiyu Wang, Caizhong Chen, Kai Liu, Ling Chen, Hang Jin, Mengsu Zeng
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引用次数: 0
Diastolic dysfunction in patients with Fontan palliation is associated with death and heart transplantation. Fontan姑息治疗患者的舒张功能障碍与死亡和心脏移植有关。
IF 6.1 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-12-01 Epub Date: 2025-09-17 DOI: 10.1016/j.jocmr.2025.101961
Edward H Hardison, Christopher C Henderson, Rachel K Duncan, Kristen George-Durrett, James C Slaughter, Ryan D Byrne, Joshua D Chew, Benjamin P Frischhertz, David A Parra, Angela J Weingarten, Jonathan H Soslow, Daniel E Clark

Background: Adults with Fontan failure (FF) have variable presentations and are often diagnosed late. Reliable predictors of FF are unknown. Diastolic dysfunction may be associated with adverse outcomes late after Fontan palliation.

Methods: Fontan patients were compared to healthy controls. FF was defined as death, transplant, diagnosis of protein-losing enteropathy, peak VO2 <50% predicted, or new diuretic requirement. All phases in the short-axis plane were contoured to calculate filling and ejection curves. The following variables were measured by cardiovascular magnetic resonance (CMR): peak filling rate (PFR), peak ejection rate (PER), PFR and PER indexed to end diastolic volume (EDV), time to PFR (tPFR), and time to PER (tPER).

Results: Compared to healthy controls (N=96), the Fontan group (N=98) had worse diastolic function as evidenced by decreased PFR and PFR/EDV and increased tPFR. Patients with FF (N=39) had similar ventricular systolic function and volumetrics to the Fontan subjects without failure (NF; N=59). PFR/EDV was significantly reduced, and indexed common ventricular mass was significantly higher among FF patients with the most severe adverse outcomes of death or heart transplantation. The prevalence of late gadolinium enhancement was higher in the FF cohort than the NF cohort.

Conclusion: CMR can identify diastolic dysfunction in the Fontan population. Patients with Fontan circulation who died or had a combined outcome of death or transplant had worse diastolic function by CMR compared to Fontan patients without death or transplant.

背景:成人丰坦衰竭(FF)有不同的表现,通常诊断较晚。FF的可靠预测因素尚不清楚。舒张功能障碍可能与Fontan姑息治疗后晚期的不良后果有关。方法:将Fontan患者与健康对照组进行比较。FF定义为死亡、移植、诊断为蛋白质丢失性肠病、预测峰值VO2 < 50%或新的利尿剂需求。对短轴平面内的各相进行了等高线化处理,计算了充填和出射曲线。通过心脏磁共振(CMR)测量以下变量:峰值充盈率(PFR)、峰值射血率(PER)、PFR和PER与舒张末期容积(EDV)、至PFR时间(tPFR)和至PER时间(tPER)。结果:与健康对照组(N=96)相比,方丹组(N=98)的舒张功能较差,表现为PFR和PFR/EDV降低,tPFR升高。FF患者(N=39)的心室收缩功能和容积指标与Fontan受试者相似,均无衰竭(NF; N=59)。在以死亡或心脏移植为最严重不良结局的FF患者中,PFR/EDV显著降低,指标总心室质量显著升高。晚期钆增强在FF组的发生率高于NF组。结论:CMR可以识别丰坦人群的舒张功能障碍。与未死亡或未移植的Fontan患者相比,死亡或合并死亡或移植的Fontan循环患者的CMR舒张功能更差。
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引用次数: 0
Visually assessed ischemia on cardiac magnetic resonance, but not quantitative perfusion metrics, predicts symptomatic improvement in coronary artery bypass. 通过心脏磁共振目视评估缺血程度,而不是定量灌注指标,可以预测冠状动脉搭桥术的症状改善。
IF 6.1 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-12-01 Epub Date: 2025-09-04 DOI: 10.1016/j.jocmr.2025.101953
Tamim Akbari, Lukas Mach, Daniel J Hammersley, Suzan Hatipoglu, Ruth Owen, Dylan Taylor, Joyce Wong, Shahzad G Raja, Sunil K Bhudia, Dudley J Pennell, Brian P Halliday, Richard E Jones, Sanjay K Prasad

Background: Serial perfusion cardiovascular magnetic resonance (CMR) in symptomatic patients undergoing coronary artery bypass grafting (CABG) may provide mechanistic insight into dynamic abnormalities of the myocardium.

Objectives: To assess how changes in cardiac reperfusion and remodeling associate with symptom improvement in patients undergoing CABG METHODS: Patients awaiting elective CABG completed serial quality of life questionnaires and detailed CMR at baseline and at 6-12 months post-CABG as per protocol. Automated fully quantitative stress and rest myocardial blood flow was calculated, alongside assessment of the visual ischemic burden. Findings were correlated with changes in symptomatology.

Results: Of 40 patients who underwent serial evaluation with CMR (mean age 62.1±9.3, median LVEF 68% [IQR: 62-73%]), there was improvement in the median visual ischemic burden (42% [IQR: 27-51] vs 18% [IQR: 11-21], P<0.001), mean global stress myocardial blood flow (1.34±0.5 mL/min/g vs 1.59±0.5 mL/min/g, P=0.002) and median global myocardial perfusion reserve (1.85±0.6 vs 2.4±0.9, P<0.001) following CABG. Greater improvement in the SAQ-7 summary score was associated with a greater decrease in the visual ischemic burden following CABG (ρ=-0.38, P=0.02). Quantitative MBF metrics did not associate with baseline or change in SAQ-7 summary score.

Conclusion: Serial perfusion CMR identifies dynamic changes in markers of myocardial perfusion in patients following CABG. Greater reduction of visually assessed ischemia associated with improvement in SAQ-7 score. Quantitative perfusion indices were not associated with symptom improvement in this study. The results also suggest residual inducible ischemia post-CABG, requiring further studies to elucidate its clinical relevance.

背景:连续灌注心血管磁共振(CMR)可以为有症状的冠状动脉旁路移植术(CABG)患者提供心肌动态异常的机制。目的:评估心脏再灌注和重构的改变与CABG患者症状改善的关系。方法:等待选择性CABG的患者在基线和CABG后6-12个月完成一系列生活质量问卷和详细的CMR。自动全定量计算应激和休息心肌血流量,同时评估视觉缺血负担。结果与症状的改变相关。结果:在40例接受CMR系列评估的患者中(平均年龄62.1±9.3岁,中位LVEF 68% [IQR: 62-73%]),中位视觉缺血负担有所改善(42% [IQR: 27-51] vs 18% [IQR: 11-21])。结论:连续灌注CMR可识别冠脉搭桥患者心肌灌注标志物的动态变化。目视评估的缺血性更大的减少与SAQ-7评分的改善相关。在本研究中,定量灌注指标与症状改善无相关性。结果还表明,CABG后残留的诱导性缺血需要进一步的研究来阐明其临床相关性。
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引用次数: 0
Toward understanding the balanced steady-state free precession signal intensity changes in cine cardiac magnetic resonance imaging: A preliminary evaluation in healthy subjects pre- and postcontrast. 对心脏磁共振成像平衡稳态自由进动信号强度变化的理解:健康受试者对比前后的初步评价。
IF 6.1 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-12-01 Epub Date: 2025-05-08 DOI: 10.1016/j.jocmr.2025.101908
Tom Dresselaers, Frederik De Keyzer, Alexandru Cernicanu, Jan Bogaert, Peter Gatehouse

Background: Although balanced steady-state free-precession (bSSFP) cines provide excellent contrast for morpho-functional cardiac evaluation, the fluctuating myocardial cine signal intensity (mcSI) is rarely used diagnostically. These mcSI fluctuations were related to through-plane motion but the impact of this motion remains unclear. We aim to characterize the mid-ventricular pre- and postcontrast bSSFP cyclic mcSI fluctuations in healthy subjects and compare these to Bloch simulations incorporating through-plane motion.

Methods: Retrospectively-gated mid-ventricular short-axis cine bSSFP images from healthy subjects (n = 49) acquired at 1.5T pre- and early postcontrast were analyzed. First, the mcSI fluctuations during the heart cycle were determined and their timing compared to the radial myocardial motion. Next, pre- vs postcontrast differences were determined during systole, early-diastole, and late-diastole. Finally, Bloch simulations and acquisitions in a moving T1 phantom were performed to analyze the through-plane motion effect on the bSSFP and spoiled gradient echo (SGRE) mcSI.

Results: The bSSFP mcSI showed a three-peak pattern both pre- and postcontrast, corresponding to the contraction and relaxation phases. However, the mcSI peaks showed a time lag vs the times of maximum radial velocity that was larger for the systolic contraction than for the early or late-diastolic relaxation phases. In addition, the shape and amplitude of the systolic and early diastolic mcSI peaks changed significantly post- vs precontrast. Bloch simulations showed an in-vivo-like (regional) three-peak signal profile and similar changes for post- vs precontrast T1 levels. Finally, results in the moving phantom and accompanying simulations confirmed a slice-thickness-dependent time lag between the motion and mcSI profile in both bSSFP and SGRE.

Conclusion: In healthy subjects before and after contrast, the bSSFP mcSI variation during the heart cycle is characterized by a three-peak pattern associated with the contraction and relaxation phases. However, the delays in timing of these peaks vs the myocardial motion, as well as the differences between pre- and postcontrast, vary with the stage of the heart cycle. Bloch simulations suggest that these mcSI fluctuations are largely determined by the regional through-slice motion. A better understanding of these motion-induced contrast mechanisms may be beneficial to methods exploiting bSSFP mcSI.

背景:平衡稳态自由进动(bSSFP)影像为心脏形态功能评估提供了极好的对比。在心脏周期中,心肌电影信号强度(mcSI)波动尚未被认为与诊断相关,部分原因是透平面运动对mcSI的影响尚不清楚。目的:我们的目的是表征健康受试者中心室对比前和对比后bSSFP周期mcSI波动,并将其与包含贯穿平面运动的Bloch模拟和运动幻影中的获取进行比较。方法:回顾性分析健康受试者(n=49)在1.5 Tesla造影前和造影后早期获得的中心室短轴电影bSSFP图像。首先,测定心脏周期内的mcSI波动,并将其与径向心肌运动相比较。接下来,在收缩期、舒张期早期和舒张期晚期测定对比前后的差异。最后,在移动的T1模体中进行了Bloch模拟和采集,分析了通过平面运动对bSSFP和破坏梯度回波(SGRE) mcSI的影响。结果:对比前后bSSFP mcSI呈三峰模式,对应于收缩期和松弛期。然而,mcSI峰值相对于最大径向速度的时间有一定的滞后,收缩期的峰值比舒张早期或晚期的峰值要大。此外,收缩期和舒张期早期mcSI峰值的形状和幅度与对比前相比发生了显著变化。布洛赫模拟显示了体内(局部)三峰信号轮廓,对比后T1水平也有类似的变化。最后,运动幻影的结果和伴随的模拟证实了bSSFP和SGRE中运动和mcSI分布之间的薄片厚度相关的时间滞后。结论:在对比前后的健康受试者中,bSSFP mcSI在心脏周期中的变化具有与收缩和舒张相相关的三峰模式。然而,与心肌运动相比,这些峰值的时间延迟,以及对比前后的差异,随着心脏周期的阶段而变化。布洛赫模拟表明,这些mcSI波动很大程度上是由区域穿片运动决定的。更好地了解这些运动诱导的对比机制可能有助于开发bSSFP心肌电影SI的方法。
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引用次数: 0
Redefining CMR reference standards through prognostic validation. 通过预后验证重新定义CMR参考标准。
IF 6.1 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-12-01 Epub Date: 2025-10-11 DOI: 10.1016/j.jocmr.2025.101970
Zahra Raisi-Estabragh, Matthias G Friedrich
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引用次数: 0
ΔR1blood, a surrogate of blood-pool gadolinium concentration, is related to body mass index, gender, left ventricular end-diastolic volume index, cardiac index, and field strength at cardiac magnetic resonance late enhancement imaging. ΔR1blood是血池钆浓度的替代物,与BMI、性别、LVEDVi、心脏指数、心脏磁共振后期增强成像场强度相关。
IF 6.1 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-12-01 Epub Date: 2025-06-25 DOI: 10.1016/j.jocmr.2025.101929
Patrick Doeblin, Shing Ching, Wensu Chen, Natalia Solowjowa, Stefanie Maria Werhahn, Rebecca Elisabeth Beyer, Misael Estepa, Christian Stehning, Jeffrey Ji-Peng Li, Henryk Dreger, Sebastian Kelle

Background: Late gadolinium enhancement imaging is the cornerstone of tissue characterization via cardiac magnetic resonance imaging. The contrast-enhancing effect of gadolinium is caused by a linear increase in tissue longitudinal R1 relaxation rates (R1 = 1/T1). The change in R1 of blood pre- and post-contrast (ΔR1blood) is therefore a surrogate for the blood-pool gadolinium concentration, which in turn correlates linearly to the tissue gadolinium concentration. The total volume of distribution for gadolinium is the extracellular volume of the body, which differs with body composition, potentially leading to variations in blood-pool and tissue gadolinium concentrations.

Methods: This study is a hypothesis-generating secondary analysis of a dataset of 1098 patients who underwent contrast cardiovascular magnetic resonance between August 2014 and November 2020 at a tertiary center. ΔR1blood was calculated from T1 relaxation time maps acquired before and approximately 15 min after application of 0.15 mmol/kg gadobutrol. Explorative data analysis and multiple linear regression were performed to assess the influence of body mass index (BMI), gender, age, cardiac index (CI), hematocrit (Hct), and left ventricular end-diastolic volume index (LVEDVi) on ΔR1blood.

Results: In bivariate analysis, ΔR1blood showed moderate correlation to BMI and weak correlation to LVEDVi, Hct, and CI. The correlation to BMI was higher in women (r = 0.52 at 1.5T and r = 0.47 at 3T) than in men (r = 0.27 at 1.5T and r = 0.37 at 3T). Multiple linear regression showed independent predictive value of BMI, BMI:gender, gender, CI, field strength (FS), and LVEDVi (R² = 0.268, P < 0.001), with BMI remaining the strongest individual predictor (b = 0.032 [0.025; 0.040], η² = 0.13, P < 0.001).

Conclusion: ΔR1blood, a measurement of gadolinium contrast enhancement in the blood-pool and a surrogate of plasma CGd at the time of late enhancement imaging, showed moderate association with BMI, FS, and gender and weak association with LVEDVi and CI. Further research is necessary to assess the need for individualized gadolinium dosing.

背景:晚期钆增强(LGE)成像是通过心脏磁共振成像进行组织表征的基础。钆的对比增强作用是由组织纵向R1弛豫速率(R1=1/T1)线性增加引起的。因此,对比前后血液R1的变化(ΔR1blood)是血池钆浓度的替代品,而血池钆浓度又与组织钆浓度呈线性相关。钆的总分布体积是身体的细胞外体积,它随身体成分的不同而不同,可能导致血池和组织中钆浓度的变化。方法:本研究是对2014年8月至2020年11月在三级中心接受对比CMR的1098例患者的数据集进行假设生成的二次分析。ΔR1blood由之前和近似获得的T1松弛时间图计算得到。0.15mmol/kg gadobutrol应用15min后。采用探索性数据分析和多元线性回归评估体重指数(BMI)、性别、年龄、心脏指数(CI)、红细胞压积(HCT)和左室舒张末期容积指数(LVEDVi)对ΔR1blood的影响。结果:在双变量分析中,ΔR1blood与BMI呈中等相关性,与LVEDVi、Hct、CI呈弱相关性。女性与BMI的相关性(1.5T时r=0.52, 3T时r=0.47)高于男性(1.5T时r=0.27, 3T时r=0.37)。多元线性回归显示BMI、BMI:性别、性别、心脏指数(CI)、场强(FS)、LVEDVi具有独立的预测值(R²=)。268, p结论:ΔR1blood,血池钆造影剂增强的测量和晚期增强成像时血浆CGd的替代品,与BMI、FS和性别有中等相关性,与LVEDVi和CI有弱相关性。需要进一步的研究来评估个体化钆剂量的必要性。
{"title":"ΔR1<sub>blood</sub>, a surrogate of blood-pool gadolinium concentration, is related to body mass index, gender, left ventricular end-diastolic volume index, cardiac index, and field strength at cardiac magnetic resonance late enhancement imaging.","authors":"Patrick Doeblin, Shing Ching, Wensu Chen, Natalia Solowjowa, Stefanie Maria Werhahn, Rebecca Elisabeth Beyer, Misael Estepa, Christian Stehning, Jeffrey Ji-Peng Li, Henryk Dreger, Sebastian Kelle","doi":"10.1016/j.jocmr.2025.101929","DOIUrl":"10.1016/j.jocmr.2025.101929","url":null,"abstract":"<p><strong>Background: </strong>Late gadolinium enhancement imaging is the cornerstone of tissue characterization via cardiac magnetic resonance imaging. The contrast-enhancing effect of gadolinium is caused by a linear increase in tissue longitudinal R1 relaxation rates (R1 = 1/T1). The change in R1 of blood pre- and post-contrast (ΔR1<sub>blood</sub>) is therefore a surrogate for the blood-pool gadolinium concentration, which in turn correlates linearly to the tissue gadolinium concentration. The total volume of distribution for gadolinium is the extracellular volume of the body, which differs with body composition, potentially leading to variations in blood-pool and tissue gadolinium concentrations.</p><p><strong>Methods: </strong>This study is a hypothesis-generating secondary analysis of a dataset of 1098 patients who underwent contrast cardiovascular magnetic resonance between August 2014 and November 2020 at a tertiary center. ΔR1<sub>blood</sub> was calculated from T1 relaxation time maps acquired before and approximately 15 min after application of 0.15 mmol/kg gadobutrol. Explorative data analysis and multiple linear regression were performed to assess the influence of body mass index (BMI), gender, age, cardiac index (CI), hematocrit (Hct), and left ventricular end-diastolic volume index (LVEDVi) on ΔR1<sub>blood</sub>.</p><p><strong>Results: </strong>In bivariate analysis, ΔR1<sub>blood</sub> showed moderate correlation to BMI and weak correlation to LVEDVi, Hct, and CI. The correlation to BMI was higher in women (r = 0.52 at 1.5T and r = 0.47 at 3T) than in men (r = 0.27 at 1.5T and r = 0.37 at 3T). Multiple linear regression showed independent predictive value of BMI, BMI:gender, gender, CI, field strength (FS), and LVEDVi (R² = 0.268, P < 0.001), with BMI remaining the strongest individual predictor (b = 0.032 [0.025; 0.040], η² = 0.13, P < 0.001).</p><p><strong>Conclusion: </strong>ΔR1<sub>blood</sub>, a measurement of gadolinium contrast enhancement in the blood-pool and a surrogate of plasma C<sub>Gd</sub> at the time of late enhancement imaging, showed moderate association with BMI, FS, and gender and weak association with LVEDVi and CI. Further research is necessary to assess the need for individualized gadolinium dosing.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101929"},"PeriodicalIF":6.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12745147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comparison of T1ρ with native T1 and T2 mapping for detecting edema in takotsubo cardiomyopathy. T1ρ与天然T1、T2测图检测Takotsubo心肌病水肿的比较。
IF 6.1 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-12-01 Epub Date: 2025-09-25 DOI: 10.1016/j.jocmr.2025.101965
Liene Balode, Robert Kelly, David M Higgins, David Gamble, Dana Dawson, P James Ross

Background: The use of parametric T1 mapping and T2 mapping cardiovascular magnetic resonance (CMR) in takotsubo cardiomyopathy has shown elevated native T1 and T2 relaxation times. In addition to native T1 and T2 mapping, a new native image parametric mapping method using T1 relaxation in the rotating frame (T1ρ) has shown potential to assess myocardial tissue characterization. This study aims to compare T1ρ with native T1 and T2 myocardial mapping in takotsubo cardiomyopathy.

Methods: T1ρ, T2, and native T1 relaxation times were obtained for 51 patients (96% (49/51) female, mean age 69) diagnosed with takotsubo cardiomyopathy and 16 healthy subjects (100% (16/16) female, mean age 41). The baseline scan for the takotsubo cohort was done within 3 weeks after symptom onset, with follow-up scans carried out on average 9 weeks after the baseline scan. Cardiac function and T1ρ, T2, native T1 maps of basal, mid, and apical segments were analyzed.

Results: A significant increase in T1ρ relaxation time was measured in mid and apical segments for the takotsubo baseline cohort compared to takotsubo follow-up cohort (p = 0.0006, p = 0.0011, respectively). A significant increase in T1ρ relaxation time was measured in mid and apical segments for the takotsubo baseline cohort compared to the healthy volunteer cohort (p < 0.0001, p < 0.0001, respectively). Significantly elevated T2 and native T1 relaxation were observed in basal (p = 0.0344, p = 0.0109, respectively), mid (p < 0.0001, p < 0.0001, respectively), and apical (p < 0.0001, p < 0.0001, respectively) segments for takotsubo baseline scans when compared to the takotsubo follow-up cohort. Significant increase in T2 and native T1 relaxation values was also observed in basal (p = 0.0038, p < 0.0001, respectively), mid (p < 0.0001, p < 0.0001, respectively), and apical (p < 0.0001, p < 0.0001, respectively) segments for takotsubo baseline cohort when compared to the healthy volunteer cohort.

Conclusion: In patients with takotsubo cardiomyopathy, T1ρ values were significantly elevated in the mid and apical segments, where edema is more pronounced. In contrast, both T2 and native T1 values were significantly increased across all three segments-basal, mid, and apical. Consequently, native T1 and T2 mapping showed superior ability to detect edema compared to T1ρ mapping.

背景:参数T1映射和T2映射心血管磁共振(CMR)在takotsubo心肌病中的应用显示原生T1和T2松弛时间升高。除了原生T1和T2映射之外,一种使用旋转框架(T1ρ)中的T1松弛的新的原生图像参数映射方法已经显示出评估心肌组织特征的潜力。本研究旨在比较takotsubo心肌病患者的T1ρ与天然T1和T2心肌测图。方法:测定51例takotsubo型心肌病患者(96%为女性,平均年龄69岁)和16例健康者(100%为女性,平均年龄41岁)的T1ρ、T2和天然T1松弛时间。takotsubo队列的基线扫描在症状出现后三周内完成,随访扫描平均在基线扫描后九周进行。分析心功能及基底、中、尖节段T1ρ、T2、原生T1图。结果:与takotsubo随访组相比,takotsubo基线组中和根尖段T1ρ松弛时间显著增加(p=0.0006, p=0.0011)。与健康志愿者组相比,takotsubo基线组的中部和根尖节段T1ρ松弛时间显著增加(结论:takotsubo心肌病患者的中部和根尖节段T1ρ值显著升高,其中水肿更为明显。相比之下,T2和原生T1值在所有三个节段(基部、中部和根尖)均显著增加。因此,与T1ρ测图相比,原生T1和T2测图显示出更好的检测水肿的能力。
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引用次数: 0
Longitudinal trajectories of left ventricular myocardial remodeling: associations with cardiovascular risk factors in the multi-ethnic study of atherosclerosis. 多民族动脉粥样硬化研究中左心室心肌重构的纵向轨迹与心血管危险因素的关联
IF 6.1 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-12-01 Epub Date: 2025-08-22 DOI: 10.1016/j.jocmr.2025.101943
Charlène A Mauger, Bharath Ambale-Venkatesh, Avan Suinesiaputra, David A Bluemke, Colin O Wu, Joao A C Lima, Alistair A Young

Background: Understanding the influence of cardiovascular risk factors on longitudinal cardiac remodeling requires three-dimensional analysis of longitudinal shape changes beyond scalar indicators such as mass and volumes. The aim of this study is to determine trajectories of cardiovascular risk factor-related remodeling in a large cohort imaging study.

Methods: We examined 2521 participants (54% female, aged 60±9 years) of the multi-ethnic study of atherosclerosis (MESA) at baseline and after 10years. Myocardial remodeling was assessed by longitudinal left ventricular shape trajectories derived from cardiac magnetic resonance imaging using a statistical shape atlas. Penalized logistic regression was used to examine the associations between trajectory scores and cardiovascular risk factors, after adjustment for sex and age at baseline. Multivariate regression was used to determine independent shape changes associated with each risk factor.

Results: Between baseline and follow-up, there was a higher prevalence of hypertension (18.4%), antihypertensive medication usage (21.6%), statin usage, and treated diabetes mellitus (8.9%); all p<0.05. Longitudinal shape trajectory scores had stronger associations with obesity, high blood pressure, hypertension medication, and diabetes mellitus, than mass and volume changes (p<0.05). Multivariate regression showed independent longitudinal changes in wall thickening with obesity (13% increase), smoking (11% decrease), and high systolic blood pressure (5.6% increase), with distinct regional variations.

Conclusion: Trajectories of cardiovascular risk factor-related longitudinal remodeling can be examined using shape atlases. In addition to global changes, each risk factor is associated with a distinct regional remodeling of the myocardium.

背景:了解心血管危险因素对纵向心脏重构的影响,除了质量、体积等标量指标外,还需要对纵向形状变化进行三维分析。本研究的目的是在一项大型队列成像研究中确定心血管危险因素相关重构的轨迹。方法:我们在基线和10年后检查了多种族动脉粥样硬化研究(MESA)的2521名参与者(54%为女性,年龄60±9y)。利用统计形状图谱,通过心脏磁共振成像得出的纵向左心室形状轨迹来评估心肌重构。在调整基线时的性别和年龄后,使用惩罚逻辑回归来检查轨迹评分与心血管危险因素之间的关系。采用多元回归来确定与每个危险因素相关的独立形状变化。结果:在基线和随访期间,高血压患病率(18.4%)、降压药使用率(21.6%)、他汀类药物使用率和已治疗的糖尿病患病率(8.9%)较高;p < 0.05。纵向形状轨迹评分与肥胖、高血压、高血压药物和糖尿病的相关性强于质量和体积变化。结论:利用形状地图集可以检测心血管危险因素相关的纵向重塑轨迹。除了全局变化外,每个危险因素都与心肌的不同区域重构有关。
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引用次数: 0
2025 ACC/AHA/ASE/ASNC/SCCT/SCMR Advanced Training Statement on Advanced Cardiovascular Imaging: A Report of the ACC Competency Management Committee. 2025 ACC/AHA/ASE/ASNC/SCCT/SCMR高级心血管成像高级培训声明:ACC能力管理委员会报告
IF 6.1 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-12-01 Epub Date: 2025-11-19 DOI: 10.1016/j.jocmr.2025.101977
Lauren A Baldassarre, Lisa A Mendes, Ron Blankstein, Rebecca T Hahn, Amit R Patel, Raymond Russell, Suhny Abbara, Shawn M Ahmad, Mary Beth Brady, Renee P Bullock-Palmer, João L Cavalcante, Panithaya Chareonthaitawee, Tiffany Chen, Daniel E Clark, Darcy Green Conaway, Melissa A Daubert, Jennifer Day, Marcelo F Di Carli, Patrycja Galazka, Cesia Gallegos-Kattán, Howard Herrmann, Edwin C Ho, Christine L Jellis, Viet T Le, Penelope C Lema, Diana E Litmanovich, Stephen H Little, Jennifer E Liu, Juan C Lopez-Mattei, Alan B Lumsden, S Chris Malaisrie, Rowlens M Melduni, Koen Nieman, Sara Nikravan, Karen G Ordovas, Purvi Parwani, Krishna K Patel, Dawn R Phoubandith, Lynn R Punnoose, Frank J Rybicki, William F Sensakovic, Michael D Shapiro, Brett W Sperry, David Spragg, Matthew S Tong, Esther Vogel-Bass, Annabelle Santos Volgman, Anam Waheed, Gaby Weissman, Bryan J Wells
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引用次数: 0
Myocardial blood flow quantification in patients with an implanted cardiodefibrillator during stress and at rest using a wideband perfusion pulse sequence: an initial feasibility study. 使用宽带灌注脉冲序列对植入心脏除颤器的患者在压力和休息时的心肌血流进行量化:初步可行性研究。
IF 6.1 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-12-01 Epub Date: 2025-09-04 DOI: 10.1016/j.jocmr.2025.101952
Lexiaozi Fan, Maria Davo Jimenez, Dima Bishara, Jacqueline Urban, Kyungpyo Hong, Austin E Culver, Jeremy D Collins, Li-Yueh Hsu, Shuo Wang, Amit R Patel, Oluyemi B Aboyewa, Cagdas Topel, Daniel C Lee, Daniel Kim

Background: Although a recently developed wideband perfusion sequence has shown diagnostically acceptable image quality and accurate myocardial blood flow (MBF) quantification at rest in patients with cardiac implanted electronic devices, its performance during vasodilator stress remains unproven. This study aims to determine whether the sequence produces diagnostically acceptable image quality during stress and is capable of quantitatively detecting abnormal stress MBF and myocardial perfusion reserve (MPR) in patients with implanted cardiodefibrillators (ICDs).

Methods: We enrolled 29 patients with an ICD (mean age=63±15years, 17 males, 12 females) and 11 control patients (mean age=50±17years, 6 males, 5 females; negative coronary artery disease; negative stress perfusion CMR; and no cardiac event one year post CMR) with an ICD taped below the left clavicle to mimic image artifacts. Both groups underwent imaging using a six-fold accelerated wideband perfusion sequence during adenosine stress and at rest. Images were reconstructed using a compressed sensing framework. Two clinical readers independently graded the following three categories on a 5-point Likert scale (1: worst, 3: clinically acceptable, 5: best): conspicuity of wall enhancement, noise, and artifact. Pixel-wise stress-rest MBF maps were quantified for both global and segmental analysis. MPR was calculated as the ratio of mean stress to rest MBFs.

Results: The median summed visual score was above the acceptable cut-point (>9.0) and not significantly different between the two groups. Both mean global and segmental stress MBF and MPR were significantly lower (p<0.05) in the ICD patient group (global MBF=1.79±0.50 mL/g/min; global MPR=2.11±0.53) compared to the control group (global MBF=2.92±0.52 mL/g/min; global MPR=3.28±0.57), while rest MBF showed no significant difference (global MBF=0.88±0.18 mL/g/min in the patient group vs. 0.92±0.13 mL/g/min in the control group).

Conclusion: This study demonstrates the feasibility of using a six-fold accelerated wideband perfusion pulse sequence, which provides diagnostically acceptable image quality during stress and is sensitive for detecting abnormal stress MBF and MPR in patients with ICDs.

背景:尽管最近开发的宽带灌注序列显示出诊断上可接受的图像质量和心脏植入电子设备(CIEDs)患者静止时准确的心肌血流量(MBF)量化,但其在血管扩张剂应激下的表现仍未得到证实。本研究旨在确定该序列是否在应激状态下产生诊断上可接受的图像质量,并能够定量检测植入心脏除颤器(ICDs)患者的异常应激MBF和心肌灌注储备(MPR)。方法:我们招募了29例ICD患者(平均年龄= 63±15岁,男性17例,女性12例)和11例对照患者(平均年龄= 50±17岁,男性6例,女性5例;冠状动脉疾病阴性;负应激灌注CMR; CMR后一年无心脏事件),将ICD贴在左锁骨下方以模拟图像伪影。两组在腺苷应激和静息时均采用六倍加速宽带灌注序列进行成像。利用压缩感知框架重构图像。两名临床读者按照5分李克特量表(1分最差,3分临床可接受,5分最佳)对以下三类进行独立评分:壁增强的显著性、噪音和伪影。逐像素应力-休息MBF图被量化,用于全局和分段分析。MPR计算为平均应力与静息mbf的比值。结果:两组患者的中位视力评分均高于可接受临界值(>9.0),两组间差异无统计学意义。ICD患者组整体和节段平均应激MBF和MPR(整体MBF=1.79±0.50ml/g/min,整体MPR=2.11±0.53)均显著低于对照组(整体MBF=2.92±0.52ml/g/min,整体MPR=3.28±0.57),而休息MBF无显著差异(患者组整体MBF=0.88±0.18ml/g/min,对照组0.92±0.13ml/g/min)。结论:本研究证明了使用六倍加速宽带灌注脉冲序列的可行性,该序列在应激期间提供诊断可接受的图像质量,并且对检测icd患者异常应激MBF和MPR敏感。
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Journal of Cardiovascular Magnetic Resonance
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